Relevant bibliographies by topics / Meningioma

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Meningioma'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Meningioma.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Meningioma"

1

Darshan, H. R., Biren Khimji Patel, Ajit Singh, Prakash Nair, Rajalakshmi Poyuran, and H. V. Easwer. "Simultaneous trigonal and spinal meningioma with varied histology: A rare case report." Surgical Neurology International 12 (December 14, 2021): 611. http://dx.doi.org/10.25259/sni_1051_2021.

Full text
Abstract:
Background: Meningioma is one of the most common neoplasms of the central nervous system. Multiple meningiomas without neurofibromatosis are not a usual occurrence. Intraventricular meningioma with spinal meningioma is rare and not been reported in the literature. Case Description: We report a case of a 63-year-old male with the left trigonal and spinal meningioma. Both the meningiomas were resected in different settings. The histological examination of tumors revealed to be of varied histology, that is, meningothelial and atypical meningioma, respectively. Conclusion: Although various cases with multiple cranial and spinal meningiomas are described, this is the first case of an intraventricular and spinal meningioma. With varied histology, the case also reaffirms the theory of polyclonal origin of multiple meningiomas.
APA, Harvard, Vancouver, ISO, and other styles
2

Singh, Arwinder, Muhammad Firdaus, Oskar Ady Widarta, Yosafat Kurniawan Sugiarto, Danny Halim, and Ahmad Faried. "Gambaran Epidemiologi Kasus Tumor Meningioma Intrakranial WHO Derajat II dan III di Rumah Sakit Kanker Dharmais." MAHESA : Malahayati Health Student Journal 3, no. 11 (November 1, 2023): 3741–52. http://dx.doi.org/10.33024/mahesa.v3i11.11573.

Full text
Abstract:
ABSTRACT Meningioma is the most common primary intracranial tumors in adults. Although most meningioma cases are regarded as benign, certain types have been suggested of having higher proliferative capacities compared to the majority. Knowing the epidemiology of the more aggressive types of meningioma are important to anticipate the disease burden and improve their management. This study aims to describe the epidemiology of WHO grade II and III intracranial meningiomas at Dharmais National Cancer Center Hospital. All patients diagnosed with WHO grade II or III intracranial meningiomas between 2011 and 2022 were included in this study. Information on patient’s characteristics, tumor location, and histopathological analyses. As many as thirty-three patients diagnosed with WHO grade II and III intracranial meningiomas between 2011 and 2022. Most patients were female (72.72%), aged between 40- to 60-year-old (57.57%), classified as WHO grade II (60.6%), and had their tumors located at convexity regions (48.48%). The most common grade II intracranial meningioma is atypical (95%), while the majority of grade III intracranial meningiomas is anaplastic (76.92%). In both WHO grade II and III intracranial meningiomas, the highest number of patients aged between 40- to 60-year-old, 60% and 53.85%, respectively. Interestingly, most WHO grade II intracranial meningiomas were in skullbase regions (50%); meanwhile, majority of WHO grade III intracranial meningiomas were in convexity regions (69.23%). Although it only represents a minor fraction from the total meningioma cases, patients who are diagnosed with WHO grade II and III intracranial meningiomas are faced with higher risks of morbidity and mortality compared to WHO grade I intracranial meningiomas. The results of this study describe the current epidemiology of this challenging tumor. Keywords : Intracranial, Meningioma, Benign, WHO Grading ABSTRAK Meningioma adalah tumor intrakranial yang paling sering terjadi pada pasien dewasa. Meskipun kebanyakan kasus meningioma intrakranial tergolong jinak, namun beberapa tipe meningioma tertentu terbukti memiliki kapasitas proliferatif yang lebih tinggi dibandingkan dengan mayoritas tipe meningioma. Pengetahuan mengenai epidemiologi dari tipe meningioma yang bersifat agresif sangatlah penting untung mengetahui beban penyakit dan melakukan upaya peningkatan manajemen penyakit ini. Penelitian ini bertujuan untuk mengetahui data epidemiologi meningioma intrakranial derajat 2 dan 3 berdasarkan klasifikasi histopatologis yang ditetapkan oleh badan kesehatan dunia / World Health Organization (WHO). Seluruh pasien yang didiagnosis dengan meningioma intrakranial derajat 2 dan 3 di RS Kanker Dharmais selama periode tahun 2011 s.d. 2022 dimasukkan ke dalam studi ini. Data mengenai karakteristik pasien, lokasi tumor, dan hasil analisis histopatologis diambil dan diolah sebagai data penelitian. Sebanyak 33 pasien didiagnosis dengan meningioma intrakranial derajat 2 dan 3 selama periode tahun 2011 s.d. 2022. Mayoritas pasien adalah perempuan (72.72%), berusia antara 40 s.d. 60 tahun (57.57%), didiagnosis dengan meningioma intrakranial derajat 2 (60.6%), dengan lokasi tumor di daerah konveksitas (48.48%). Jenis meningioma derajat 2 tersering adalah atipikal (95%), sedangkan jenis meningioma derajat 3 tersering adalah anaplastik (76.92%). Rentang usia terbanyak dari pasien penderita meningioma intrakranial derajat 2 (60%) dan 3 (53.85%) adalah 40 s.d. 60 tahun. Dalam hal lokasi tumor, lokasi tumor tersering dari meningioma derajat 2 adalah dasar tengkorak (50%), sedangkan lokasi tumor tersering dari meningioma derajat 3 adalah konveksitas (69.23%). Meskipun mayoritas pasien yang didiagnosis dengan meningioma intrakranial tergolong sebagai derajat 1, namun pasien meningioma intrakranial derajat 2 dan 3 memiliki resiko morbiditas dan mortalitas yang lebih tinggi. Hasil dari penelitian ini memaparkan data epidemiologi terkini dari jenis meningioma intrakranial yang terbilang lebih agresif. Kata Kunci: Meningioma, Intrakranial, Jinak, Derajat WHO
APA, Harvard, Vancouver, ISO, and other styles
3

Eaton, Charlotte, Abrar Choudhury, Timothy Casey-Clyde, Danielle Swaney, Nevan Krogan, and David Raleigh. "CSIG-26. NF2/MERLIN DRIVES MENINGIOMA APOPTOSIS AND SUCEPTIBILITY TO CYTOTOXIC THERAPY." Neuro-Oncology 23, Supplement_6 (November 2, 2021): vi39. http://dx.doi.org/10.1093/neuonc/noab196.152.

Full text
Abstract:
Abstract BACKGROUND Alterations in NF2 underlie meningioma tumorigenesis, but tumor suppressor functions of the NF2 gene product, Merlin, are incompletely understood in meningiomas. Here we integrate proteomic proximity-labelling mass spectrometry with CRISPR interference (CRISPRi), RNA sequencing, and biochemical approaches to discover Merlin drives meningioma apoptosis and susceptibility to cytotoxic therapy. METHODS RNA sequencing was performed on triplicate M10G meningioma cells stably expressing CRISPRi machinery and either non-targeting control sgRNAs, sgRNAs suppressing NF2, or sgRNAs suppressing NF2 with Merlin rescue. QPCR in IOMM-Lee and MSC1 meningioma cells expressing non-targeting control shRNAs or shRNAs suppressing NF2 was used for orthogonal validation in vitro. RNA sequencing of euploid meningiomas (n=52) or meningiomas with loss of NF2 as the only copy number variant (n=28) was used for orthogonal validation in vivo. Merlin interactors in meningioma cells were identified using APEX proteomic proximity-labelling mass spectrometry. Mechanistic and functional studies were performed using biochemical, molecular, and cell biology approaches in meningioma cells and CH-157MN meningioma xenografts treated with cytotoxic chemotherapy or ionizing radiation. RESULTS Merlin suppression in meningioma cells and xenografts inhibited pro-apoptotic interferon regulatory factor (IRF) target genes and attenuated meningioma apoptosis. Merlin suppression did not alter IRF stability or subcellular localization in meningioma cells, and proteomic proximity-labelling mass spectrometry revealed a novel interaction between wildtype Merlin and ARHGAP35, a DNA binding factor that inhibits glucocorticoid receptor expression (NR3C1). NR3C1 inhibits IRF activity to prevent apoptosis, and Merlin suppression in meningioma cells induced NR3C1expression, which was inhibited by Merlin rescue. Further, NR3C1 suppression rescued meningioma cell apoptosis in the absence of Merlin, and NR3C1 expression was increased in human meningiomas with loss of NF2 compared to euploid meningiomas. CONCLUSIONS These data shed light on a novel pro-apoptotic tumor suppressor function of Merlin regulating glucocorticoid signalling and susceptibility to cytotoxic therapy in meningiomas.
APA, Harvard, Vancouver, ISO, and other styles
4

Montvilaitė, R., S. R. Letautienė, R. Kvaščevičius, and A. Barkauskienė. "Intrakranijinių meningiomų radiologinių požymių ir jų histologinės diferenciacijos sąsajos: klinikinis atvejis ir literatūros apžvalga." Neurologijos seminarai 24, no. 85 (December 29, 2020): 227–40. http://dx.doi.org/10.29014/ns.2020.31.

Full text
Abstract:
Meningioma – dažniausiai pasitaikantis ne glijos kilmės centrinės nervų siste­mos navikas. Dauguma jų būna nepiktybinės, tačiau apie 20 % pasižymi mažesniu ląstelių diferenciacijos laipsniu, agresyvesne ligos eiga ir laikomos piktybinėmis. Kadangi nepiktybinių ir piktybinių meningiomų stebėjimo bei gydymo taktika skiriasi, svarbu kuo anksčiau minėtus tipus atskirti. Remiantis radiologiniais vaizdais (kompiuterinės tomografijos, mag­netinio rezonanso tomografijos), sunku prognozuoti meningiomos histologinę diferenciaci­ją, tačiau kai kurie požymiai leidžia įtarti naviką esant piktybinį. Siame straipsnyje pristato­mas recidyvavusios piktybinės intrakranijinės meningiomos klinikinis atvejis ir literatūros apžvalga, analizuojamos meningiomų radiologinių požymių koreliacijos su naviko histologine diferenciacija.
APA, Harvard, Vancouver, ISO, and other styles
5

Ahuja, Chirag, Pankaj Gupta, Abiraj Kumar, Bruttendu Moharana, and Kim Vaiphei. "Ectopic Inferior Orbital Meningioma." An International Journal Clinical Rhinology 10, no. 1 (2017): 32–35. http://dx.doi.org/10.5005/jp-journals-10013-1301.

Full text
Abstract:
ABSTRACT Aim To present a unique case of ectopic orbital meningioma presenting in anteroinferior part of orbit. Introduction Primary orbital meningiomas arise from the optic nerve sheath and constitute 10 to 30% of orbital meningiomas. Secondary orbital meningiomas represent 70 to 90% of orbital meningiomas and are the direct extension of intracranial meningiomas into the orbit. Rarely, ectopic rests of arachnoid cells give rise to meningiomas separate from optic nerve sheath. Ectopic orbit meningioma is a rare tumor arising from ectopic arachnoidal tissue. The present case report describes an elderly patient with ectopic orbital meningioma in anteroinferior quadrant. Case report A 70-year-old female patient presented with slowly growing mass in the inferior part of right orbit. This lesion was firm in consistency and not fixed to skin or bone. Computed tomography scan showed a homogeneous mass lesion in anteroinferior part of right orbit without any bony changes. The orbital mass was excised. Anatomic-pathologic evaluation of the excised specimen revealed a benign meningioma of a meningotheliomatous type. Conclusion Ectopic orbital meningioma may present in elderly patients in anteroinferior orbit. Clinical significance An ectopic orbital meningioma should be considered in differential diagnosis of firm orbital mass presenting in anteroinferior orbit. How to cite this article Gupta P, Kumar A, Moharana B, Vaiphei K, Ahuja C. Ectopic Inferior Orbital Meningioma. Clin Rhinol An Int J 2017;10(1):32-35.
APA, Harvard, Vancouver, ISO, and other styles
6

Verstegen, Marco J. T., Pepijn Van den Munckhof, Dirk Troost, and Gerrit J. Bouma. "Multiple meningiomas in a patient with Rubinstein—Taybi syndrome." Journal of Neurosurgery 102, no. 1 (January 2005): 167–68. http://dx.doi.org/10.3171/jns.2005.102.1.0167.

Full text
Abstract:
✓ The authors report a case of multiple meningiomas in a 37-year-old woman with Rubinstein—Taybi syndrome. The patient harbored a bifrontal ossifying meningioma and multiple intracranial meningiomas. She underwent surgery for the frontal ossifying meningioma and a right frontoparietal meningioma.
APA, Harvard, Vancouver, ISO, and other styles
7

Talabnin, Chutima, Thanawat Trasaktaweesakul, Pitchanun Jaturutthaweechot, Pundit Asavaritikrai, Dusit Kongnawakun, Atit Silsirivanit, Norie Araki, and Krajang Talabnin. "Altered O-linked glycosylation in benign and malignant meningiomas." PeerJ 12 (January 22, 2024): e16785. http://dx.doi.org/10.7717/peerj.16785.

Full text
Abstract:
Background Changes in protein glycosylation have been reported in various diseases, including cancer; however, the consequences of altered glycosylation in meningiomas remains undefined. We established two benign meningioma cell lines—SUT-MG12 and SUT-MG14, WHO grade I—and demonstrated the glycan and glycosyltransferase profiles of the mucin-type O-linked glycosylation in the primary benign meningioma cells compared with two malignant meningioma cell lines—HKBMM and IOMM-Lee, WHO grade III. Changes in O-linked glycosylation profiles in malignant meningiomas were proposed. Methods Primary culture technique, morphological analysis, and immunocytochemistry were used to establish and characterize two benign meningioma cell lines. The glycan profiles of the primary benign and malignant meningiomas cell lines were then analyzed using lectin cytochemistry. The gene expression of O-linked glycosyltransferases, mucins, sialyltransferases, and fucosyltransferases were analyzed in benign and malignant meningioma using the GEO database (GEO series GSE16581) and quantitative-PCR (qPCR). Results Lectin cytochemistry revealed that the terminal galactose (Gal) and N-acetyl galactosamine (GalNAc) were highly expressed in primary benign meningioma cells (WHO grade I) compared to malignant meningioma cell lines (WHO grade III). The expression profile of mucin types O-glycosyltransferases in meningiomas were observed through the GEO database and gene expression experiment in meningioma cell lines. In the GEO database, C1GALT1-specific chaperone (COSMC) and mucin 1 (MUC1) were significantly increased in malignant meningiomas (Grade II and III) compared with benign meningiomas (Grade I). Meanwhile, in the cell lines, Core 2 β1,6-N-acetylglucosaminyltransferase-2 (C2GNT2) was highly expressed in malignant meningiomas. We then investigated the complex mucin-type O-glycans structures by determination of sialyltransferases and fucosyltransferases. We found ST3 β-galactoside α-2,3-sialyltransferase 4 (ST3GAL4) was significantly decreased in the GEO database, while ST3GAL1, ST3GAL3, α1,3 fucosyltransferases 1 and 8 (FUT1 and FUT8) were highly expressed in malignant meningioma cell lines—(HKBMM)—compared to primary benign meningioma cells—(SUT-MG12 and SUT-MG14). Conclusion Our findings are the first to demonstrate the potential glycosylation changes in the O-linked glycans of malignant meningiomas compared with benign meningiomas, which may play an essential role in the progression, tumorigenesis, and malignancy of meningiomas.
APA, Harvard, Vancouver, ISO, and other styles
8

Blatová, Barbora, Karol Zeleník, Martin Formánek, Štefan Reguli, Pavla Hanzlíková, Mária Wozniaková, and Pavel Komínek. "Temporal bone meningioma." Otorinolaryngologie a foniatrie 70, no. 1 (March 20, 2021): 22–26. http://dx.doi.org/10.48095/ccorl202122.

Full text
Abstract:
The aim of this case report is to discuss a very rare pathology – temporal bone meningioma. The extracranial location of meningiomas and temporal bone meningioma is a very rare condition. The symptomatology of temporal bone meningiomas is nonspecific, imitating chronic otitis media with cholesteatoma. However, temporal bone meningioma has a distinctive image on computed tomography. There is a change in the architecture without bone destruction that should be known by otorhinolaryngologist and radiologist. Magnetic resonance paging should be performed when temporal bone meningioma is suspected. The management of temporal bone meningiomas depends on a variety of factors. The most common therapy includes a combination of neurosurgical and otological surgery. There are also alternatives like stereotactic irradiation.
APA, Harvard, Vancouver, ISO, and other styles
9

Gupta, Vinay, Yuzhuang S. Su, Christian G. Samuelson, Leonard F. Liebes, Marc C. Chamberlain, Florence M. Hofman, Axel H. Schönthal, and Thomas C. Chen. "Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas." Journal of Neurosurgery 106, no. 3 (March 2007): 455–62. http://dx.doi.org/10.3171/jns.2007.106.3.455.

Full text
Abstract:
Object There is currently no effective chemotherapy for meningiomas. Although most meningiomas are treated surgically, atypical or malignant meningiomas and surgically inaccessible meningiomas may not be removed completely. The authors have investigated the effects of the topoisomerase I inhibitor irinotecan (CPT-11) on primary meningioma cultures and a malignant meningioma cell line in vitro and in vivo. Methods The effects of irinotecan on cellular proliferation in primary meningioma cultures and the IOMM-Lee malignant meningioma cell line were measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide assay and flow cytometry. Apoptosis following drug treatment was evaluated by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling and the DNA laddering assays. The effects of irinotecan in vivo on a meningioma model were determined with a subcutaneous murine tumor model using the IOMM-Lee cell line. Irinotecan induced a dose-dependent antiproliferative effect with subsequent apoptosis in the primary meningioma cultures (at doses up to 100 μM) as well as in the IOMM-Lee human malignant meningioma cell line (at doses up to 20 μM) irinotecan. In the animal model, irinotecan treatment led to a statistically significant decrease in tumor growth that was accompanied by a decrease in Bcl-2 and survivin levels and an increase in apoptotic cell death. Conclusions Irinotecan demonstrated growth-inhibitory effects in meningiomas both in vitro and in vivo. Irinotecan was much more effective against the malignant meningioma cell line than against primary meningioma cultures. Therefore, this drug may have an important therapeutic role in the treatment of atypical or malignant meningiomas and should be evaluated further for this purpose.
APA, Harvard, Vancouver, ISO, and other styles
10

Cooney, Tab, Yan Chen, Yan Yuan, Robert Thomas Galvin, Wendy M. Leisenring, Susan A. Smith, Rebecca M. Howell, et al. "Subsequent meningiomas in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS)." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): 10058. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.10058.

Full text
Abstract:
10058 Background: Meningiomas are the most common subsequent central nervous system tumor among aging survivors of childhood cancer, yet incidence across the lifespan, occurrence of multiple meningiomas, and risk for mortality are not established. Methods: Meningiomas were identified by self-report and validated with pathology/medical records. Twenty-year cumulative incidence of meningioma (95% confidence interval) was estimated and multivariable models assessed demographic- and treatment-related meningioma risk factors. Results: Among 24,902 5-year survivors of childhood cancer diagnosed 1970-1999, we identified 472 survivors with 710 meningiomas, 145 (20.4%) of which were WHO grade 2/3. Among survivors with meningioma, 137 (28%) had ≥2 meningiomas, and 80 (16%) met criteria for meningiomatosis. The median latency from childhood cancer to first meningioma diagnosis was 26.2 years (range 5.6-48.2), and the median time from first to second meningioma (among those without meningiomatosis) was 1.4 years (range 0-30.2 years). The twenty-year cumulative incidence did not significantly decrease between survivors diagnosed in the 1970s (0.58, 95% CI 0.41-0.79) and the 1990s (0.42, 95% CI 0.32-0.55). In multivariable analysis, female sex (HR 1.52, 95% CI 1.21-1.91) and all cranial radiotherapy dose levels ( > 0-30Gy, HR 57.0, 95% CI 7.93-419.60; 30.1-50 Gy, HR 228.90, 95% CI 30.89-1695.99; > 50 Gy, HR 113.29, 95% CI 15.09-850.34) were associated with increased meningioma risk, while older age at diagnosis (10-14 years, HR 0.60, 95% CI 0.44-0.82; 15-20 years, HR 0.35, 95% CI 0.22-0.55) was associated with reduced meningioma risk. Among 71 deaths in survivors with meningioma, the most prevalent cause of death was meningioma (N = 25, 35.2%). The 5-year all-cause mortality from first meningioma diagnosis was 4.20% (95% CI: 2.44-5.96%). Conclusions: In conclusion, cranial radiation, younger diagnostic age and female sex were identified as independent meningioma risk factors in, to our knowledge, the largest study to date. The risk for meningioma-associated mortality argues for assertive meningioma surveillance and treatment in this population.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Meningioma"

1

MONTEIRO, Márcia Lima de Azevedo. "Comportamento biológico dos meningiomas: um estudo de 868 casos." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/20120.

Full text
Abstract:
Submitted by Alexandra Feitosa (alexandra.feitosa@ufpe.br) on 2017-07-28T13:51:24Z No. of bitstreams: 1 2011-tese-MárciaLimaAzevêdoMonteiro.pdf: 2593426 bytes, checksum: 4073622fec482cc2aad1b18cda61eef6 (MD5)
Made available in DSpace on 2017-07-28T13:51:24Z (GMT). No. of bitstreams: 1 2011-tese-MárciaLimaAzevêdoMonteiro.pdf: 2593426 bytes, checksum: 4073622fec482cc2aad1b18cda61eef6 (MD5) Previous issue date: 2011-03-15
Monteiro MLA. Comportamento biológico dos meningiomas: um estudo de 868 casos. [Tese de Doutorado]. Recife: Universidade Federal de Pernambuco; 2011.Introdução:Meningiomas são neoplasias, em sua maioria, de apresentação benigna. Podem, no entanto,apresentar recidiva mesmo após remoção radical. A caracterização de meningiomas e o conhecimento de fatores relacionados à recidiva é imprescindível, devido a sua prevalência, importância clínica e às possibilidades de cura através de remoção cirúrgica. Objetivos:Caracterizar meningiomas do ponto de vista clínico-patológico e de fatores relacionados a seu tratamento cirúrgico e contribuir para o conhecimento de seu comportamento biológico; determinar a prevalência de recidiva demeningiomas e verificar a influência de determinados fatores sobre a recidiva.Material e Métodos:Foram analisados 868 casos de pacientes submetidos à remoção cirúrgica de meningiomas no Hospital Nordstadt, Hannover, Alemanha, de 1978 a 1994, para gênero, distribuição etária, associação a neurofibromatose, multiplicidade, tipo e grau histológico, localização, características de crescimento do tumor e recidiva. Para análise dos resultados foram obtidas distribuições de frequências, teste 2de igualdade de proporções ao nível de 5,0% e intervalo de confiança de 95,0% para a prevalência de recidiva. Resultados:A idade dos pacientes variou de 7 a 85 anos, média e desvio padrão de 53,46 e 13,89 anos, respectivamente. Da 5aà 7adécadas, concentraram-se 71,7% dos pacientes. A distribuição por gênero foi de 74,0% femininos e 26,0% masculinos. Meningiomas clássicos representaram 94,2% do total; atípicos, 3,8%; e anaplásicos, 1,9%. Em 824 casos, 89,1% eram intracranianos (65,9% basais); 8,5%, espinhais; e 2,4%, crânio-cervicais. A ocorrência associada a neurofibromatose foi de 4,9%; e a multiplicidade, de 6,7%. Aos tumores globoides (84,6%), seguiram-os em placa (6,7%) e os intraósseos (2,4%). Cápsula foi observada em 74,5% dos casos. A remoção foi total em 79,6%. A prevalência de recidivas foi de 16.9% (14,2% a 19,5%) com 95,0% de confiança. O tempo médio entre as recidivas tendeu a diminuir: de 5,68 anos entre a 1aremoção e 1arecidiva para 0,90 anos entre a 3ae a 4arecidivas.Em 785 casos, o percentual de recidiva foi de 2,7% em dois anos; 7,2% em 5 anos; 13,1% em 10 anos; 16,3% em 15 e 16,9% em 20 anos. O percentual de recorrência foi mais elevado no gênero masculino (22,1% x 15,1%); aumentou nas 4 primeiras décadas de vida e decresceu da 5aà 9adécadas; foi menor entre os pacientes acima de 65 anos (3,0% x 20,5%); mais elevado entre os de grau III (71,4%), seguido do grau II (51,7%) e do grau I (15,1%). Percentuais mais elevados de recidiva foram encontrados entre tumores removidos parcialmente (32,7% x 11,5%); entre pacientes portadores de neurofibromatose (38,5% x 15,7%); dentre os múltiplos (34,6% x 15,5%); na presença de infiltração dural (19,6% x 13,1%), óssea (23,6% x 12,9%) e muscular (57,9% x 15,8%); e entre os não capsulados (20,7% x 8,2%). A associação da recidiva foi significativa com gênero, faixa etária, tipo e grau histológico, extensão da remoção, neurofibromatose, multiplicidade, tipo de crescimento, infiltração dural, óssea ou muscular e presença de cápsula com valores de P=0,022 para gênero, P= 0,017 para infiltração dural e P<0,001 para as demais variáveis. Para outras variáveis analisadas não se comprovou associação significativa com a recidiva. Conclusão: Dos resultados se conclui que osmeningiomas são mais frequentes em mulheres, entre a 5ae a 7a décadas de vida; a maioria é do tipo clássico, grau I, globóide, capsulada; a localização intracraniana é cerca de 10 vezes mais frequente que a espinhal; a base do crânio é uma localização frequente; a remoção total é possível para a maioria dos casos; um percentual considerável recidivou, 16,9% e a taxa de recidiva aumentou com o tempo de seguimento. A recidiva é influenciada por gênero, faixa etária, tipo e grau histológico, extensão da remoção, neurofibromatose, multiplicidade, tipo de crescimento, infiltração dural, óssea ou muscular e presença de cápsula.
Monteiro MLA. Studyonthe biological behaviorof meningiomas, an analisis of 868 cases.[PhD Thesis]. Recife. Pernambuco. Brazil:Federal University of Pernambuco; 2011.Introduction:Meningiomas are neoplasias of benign presentation in their majority. However, they can present relapse even after radical removal.The characterization of this neoplasms and knowledge of the factors relating to the surgical treatment and the search for factors related to recurrence of meningiomas is imperative, due to its prevalence, clinical importance and possibility for cure. Objective:To characterize meningiomas from a clinical-pathological point of view and the factors relating to its surgical treatment and to contribute to knowledge of its biological behavior; to determine the prevalence of relapse in meningiomas and to verify the influence of certain factors in relapse.Material and Methods:868 cases of patients subjected to the surgical removal of meningiomas at Nordstadt Hospital, Hanover, Germany, between 1978 and 1994 were analyzed for gender, age distribution, association with neurofibromatosis, multiplicity, histological type and degree, location, tumor growth characteristics and relapse. For analysis of the results, frequency distributions, c2proportional equivalence test at a level of 5.0% with a confidence interval of 95.0% for the prevalence of relapse were obtained. Results: Patient age varied from 7 to 85 years, an average and standard deviation of 53.46 and 13.89 years, respectively. 71.7% of the patients were concentrated in the 50-70 age group. Gender distribution was 74.0% female and 26.0% male. Classic meningiomas represented 94.2% of the total; atypical, 3.8%; and anaplasic, 1.9%. Of 824 cases, 89.1% were intracranial (65.9%, basal); 8.5%, spinal; and 2.4%, cranial-cervical. Association with neurofibromatosis was 4.9%; and multiplicity, 6.7%. Globoid tumors (84.6%) were followed by those en placa(6.7%) and intraosseous (2.4%). Capsulation was observed in 74.5% of the cases. Removal was total in 79.6%. The prevalence of relapse was 16.9% (14.2% to 19.5%) at 95.0% confidence. The average time between relapses tended to decrease: from 5.68 years between the first removal and the first relapse to 0.90 years between the third and fourth relapses. . In 785 cases, the percentage of relapses was 2.7% within two years; 7.2% within 5 years; 13.1% within 10 years; 16.3% within 15 years and 16.9% within 20 years. The percentage for relapse was higher in the male gender (22.1% x 15.1%); increasing in the first four decades of life and decreasing in the fifth to ninth decades; it was lower in patients over 65 years of age (3.0% x 20.5%); higher in those of degree III (71.4%), following by degree II (51.7%) and by degree I (15.1%). A higher percentage of relapse was found in partially removed tumors (32.7% x 11.5%); in patients with neurofibromatosis (38.5% x 15.7%); in multiples (34.6% x 15.5%); in the presence of dural infiltration (19.6% x 13.1%), bone (23.6% x 12.9%) and muscular (57.0% x 15.8%); and in non-encapsulated (20.7% x 8.2%). The association of relapse was significant with respect to gender, age group, histological type and degree, extent of removal, neurofibromatosis, multiplicity, growth type, dural, bone or muscular infiltration and capsule presence with values of P=0.022 for gender, P=0.017 for dural infiltration and P<0.001 for the other variables. For the other variables analyzed, there was no significant correlation to relapse. Conclusion:From the results, it is concluded that meningiomas are more frequent in women, between 50 and 70 years of age; most are classic in type, degree I, globoid, capsulated; an intracranial is about 10 times more common than a spinal location; the base of the skull is a common location; totalremoval is possible in most cases; a considerable percentage relapsed 16.9% and the recurrence rate increased with time of follow up . The association of relapse was significant with respect to gender, age group, histological type and degree, extent of removal, neurofibromatosis, multiplicity, growth type, dural, bone or muscular infiltration and capsule presence.
APA, Harvard, Vancouver, ISO, and other styles
2

Suárez, Alvarado Edwin Efraín. "Meningiomas recidivantes postquirúrgicos." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2005. https://hdl.handle.net/20.500.12672/2060.

Full text
Abstract:
Objetivo: Identificar los factores relacionados con la recurrencia de los meningiomas intracraneales operados en el Instituto Especializado de Enfermedades Neoplásicas “Eduardo Cáceres Graziani”. Material y Métodos: Estudio retrospectivo, comparativo, analítico, de caso control. La población de estudio estuvo constituida por los pacientes operados con diagnóstico anatomopatológico de meningioma intracraneal que fueron operados desde el año 1984 a 1997, con control postoperatorio a cinco años. Resultados: 55 pacientes cumplieron los criterios de inclusión; de estos, 23 (42%) presentaron recurrencia y 32 (58%) no presentaron recurrencia. Se realizó la remoción quirúrgica total en 36 pacientes y subtotal en 19 pacientes. Tuvieron recurrencia el 57.8% de los pacientes con resección quirúrgica subtotal y el 33.3% de pacientes con remoción total; esto nos da un OR de 2,7. con una p< 0.05. Con respecto al sexo, se observó mayor recurrencia del meningioma en pacientes de sexo masculino, con un OR de 1.7. La edad promedio de los pacientes con recurrencia fue de 43.9 ± 16.3 años versus 40. 85 ±17.7 del grupo control. El tiempo de recurrencia fue en promedio de 30.7 ± 16.3 meses. La localización del meningioma que más recurre fue la zona temporal, relacionada con la base de cráneo y con el ala mayor del esfenoides. El abordaje que presentó mayor recurrencia fue el frontoparietal, mientras que el frontal, parietal, frontoparietotemporal y el temporoparietal tienen menor recurrencia. Con respecto al tipo histológico no existe preponderancia de ningún tipo de meningioma con respecto a la recurrencia. Conclusiones: El factor más importante relacionado con la recurrencia del meningioma intracraneal operado fue el grado de resección quirúrgica, encontrándose que un paciente sometido a una remoción quirúrgica subtotal tiene 2,7 veces más posibilidades de presentar recurrencia del meningioma en comparación con la resección quirúrgica total.
--- Objective: To identify the factors related to the recurrence of meningioma intracraneal patient in the Specialized Institute of Neoplasicas Diseases. “Eduardo Cáceres Graziani”. Material and Methods: Retrospective, comparative, analytical study, of case control. The study population was constituted by patients with intracraneal diagnosis of meningioma patients from year 1984 to 1997, with postoperating control to five years. Results: 55 patients fulfilled the inclusion criteria; of these, 23 (42%) presented recurrence and 32 (58%) did not present recurrence. It was made total the surgical removal in 36 patients and subtotal in 19 patients. The 57,8% of the patients with subtotal surgical removal and the 33,3% of patients with total removal had recurrence; this gives a OR us of 2.7, with p< 0.05.With respect to sex, greater recurrence of meningioma in patients of masculine sex was observed, with a OR of 1.7.The age average of the patients with recurrence is of 43,9 ± 16,3 years versus 40. 85 ±17.7 of the group control. The time of recurrence ± was in average of 30,7 16,3 months. The location of meningioma that resorts more is the temporary zone, related to the base of skull and the greater wing of the esfenoides. The boarding that presents greater recurrence was the frontoparietal, whereas the frontal, parietal, frontoparietotemporal and the temporoparietal have minor recurrence. With respect to the histologic type superiority of any type of meningioma with respect to the recurrence does not exist. Conclusions: The most important factor in the recurrence of meningioma was the degree of surgical resection, being that a patient submissive subtotal a surgical removal has 2.7 times more possibilities of presenting recurrence of meningioma.
Tesis de segunda especialidad
APA, Harvard, Vancouver, ISO, and other styles
3

WADA, KENTARO, TOMOYUKI NODA, KENICHI HATTORI, HIDEKI MAKI, AKIRA KITO, and HIROFUMI OYAMA. "SURGICAL RESULTS OF PARASAGITTAL AND FALX MENINGIOMA." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16041.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Almeida, Luciana Oliveira de. "Análise epigenética e de polimorfismos em tumores extra-axiais do sistema nervoso." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-02032010-121437/.

Full text
Abstract:
Os tumores extra-axias do sistema nervoso são de localização extra-cerebral e na maioria das vezes benignos; meningiomas, schwanomas e metástases fazem parte deste grupo. O aparecimento de um tumor ocorre a partir do acúmulo de alterações genéticas e epigenéticas nas células. Para entender o mecanismo molecular da progressão tumoral e a formação de metástases é indispensável identificar os genes que acumulam essas alterações. Sendo assim, este trabalho teve como objetivo analisar o perfil de metilação dos genes TP16, TP53, DAL-1, GSTP-1, MEN-1, NDRG2 e das DNA metiltransferases 3A, 3B e 3L e sua associação com os tumores extra-axiais e ainda, avaliar, através de um estudo caso-controle, a influência dos SNPs TP53 Pro47Ser e Arg72Pro, EGF + 61, GSTP-1 Ile105Val e WRN Cys1367Arg no desenvolvimento e prognóstico desses tumores. A técnica utilizada para a análise de hipermetilação foi a MSP, e através dela observamos que a atividade das DNMTs não está associada à metilação dos tumores extra-axiais e ainda, os perfis de metilação das DNMTs de novo não estão associados com alterações no padrão de metilação dos genes TP16, TP53, DAL-1, GSTP-1, MEN- 1 e NDRG2. Observamos que a metilação do gene TP53 está associada principalmente aos tumores de maior grau de malignidade, a uma deficiência na resposta a tratamentos e, conseqüentemente, a um maior número de óbitos. A metilação do gene TP16 está envolvida mais freqüentemente na formação de schwanomas e a de NDRG2 na progressão dos meningiomas. A análise de polimorfismos foi realizada através da técnica de PCR-RFLP e observamos diferenças nas distribuições genotípicas entre pacientes e controles nos SNPs TP53 Pro47Ser e Arg72Pro, EGF + 61 e GSTP-1 Ile105Val, onde as variantes Ser47, Pro72, EGF G61 e Val105 foram observadas com maior freqüência entre os portadores de tumores extra-axiais. Dessa forma, estas variantes podem ser fatores de susceptibilidade para o desenvolvimento dos tumores.
The extra-axial brain tumors have extra-brain localization and in most of the time they are benign, meningiomas, schwannomas and metastasis are included in this group. The appearance of a tumor occurs because of the accumulation of genetic and epigenetic alterations in the cells. In order to understand the molecular mechanism of the tumor progression and the metastasis formation it is important to identify the genes that accumulate the alterations. Thereby, the objective of this study was to analyze the methylation profile of the genes TP16, TP53, DAL-1, GSTP-1, MEN-1, NDRG2 and the DNA methyltransferases 3A, 3B and 3L and their association with the extra-axial brain tumors. Another purpose was to determine, in a case-control study, the roles of the TP53 Pro47Ser and Arg72Pro, EGF + 61, GSTP-1 Ile105Val and WRN Cys1367Arg SNPs in the development and prognosis of these tumors. We used the MSP to screen the hypermethylation profile and we observed no association between the DNMTs activity and the hypermethylation of the tumors. We also did not find association between the methylation of the DNMTs de novo and alterations in the methylation profile of the genes TP16, TP53, DAL-1, GSTP-1, MEN-1 and NDRG2. We observed that TP53 hypermethylation was associated with the high grade tumors, a poor response to the treatments and, consequently, the high number of obits. The TP16 methylation was involved with the shwannomas formation and the NDRG2 gene was involved in the meningiomas progression. For the polymorphism analysis, we used the PCR-RFLP technique and we observed differences in the genotype distributions between cases and controls of TP53 Pro47Ser and Arg72Pro, EGF + 61 and GSTP-1 Ile105Val SNPs, where the variants Ser47, Pro72, EGF G61 and Val105 were more frequent in patients than in controls. Thus, these variants can be important factors of susceptibility to the tumor development.
APA, Harvard, Vancouver, ISO, and other styles
5

Qureshi, Hammad A. "Meningioma classification using an adaptive discriminant wavelet packet transform." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/2790/.

Full text
Abstract:
Meningioma subtypes classification is a real world problem from the domain of histological image analysis that requires new methods for its resolution. Computerised histopathology presents a whole new set of problems and introduces new challenges in image classification. High intra-class variation and low inter-class differences in textures is often an issue in histological image analysis problems such as Meningioma subtypes classification. In this thesis, we present an adaptive wavelets based technique that adapts to the variation in the texture of meningioma samples and provides high classification accuracy results. The technique provides a mechanism for attaining an image representation consisting of various spatial frequency resolutions that represent the image and are referred to as subbands. Each subband provides different information pertaining to the texture in the image sample. Our novel method, the Adaptive Discriminant Wavelet Packet Transform (ADWPT), provides a means for selecting the most useful subbands and hence, achieves feature selection. It also provides a mechanism for ranking features based upon the discrimination power of a subband. The more discriminant a subband, the better it is for classification. The results show that high classification accuracies are obtained by selecting subbands with high discrimination power. Moreover, subbands that are more stable i.e. have a higher probability of being selected provide better classification accuracies. Stability and discrimination power have been shown to have a direct relationship with classification accuracy. Hence, ADWPT acquires a subset of subbands that provide a highly discriminant and robust set of features for Meningioma subtype classification. Classification accuracies obtained are greater than 90% for most Meningioma subtypes. Consequently, ADWPT is a robust and adaptive technique which enables it to overcome the issue of high intra-class variation by statistically selecting the most useful subbands for meningioma subtype classification. It overcomes the issue of low inter-class variation by adapting to texture samples and extracting the subbands that are best for differentiating between the various meningioma subtype textures.
APA, Harvard, Vancouver, ISO, and other styles
6

WADA, KENTARO, TOMOYUKI NODA, KENICHI HATTORI, HIDEKI MAKI, AKIRA KITO, and HIROFUMI OYAMA. "POSTOPERATIVE RECOVERY FROM UNILATERAL BLINDNESS CAUSED BY TUBERCULUM SELLAE MENINGIOMA." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16036.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Prager, Briana C. "THE MENINGIOMA ENHANCER LANDSCAPE DELINEATES PROGNOSTIC SUBGROUPS AND DRIVES DRUGGABLE DEPENDENCIES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1595620620551252.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Okuchi, Sachi. "Grading Meningioma: A Comparative Study of Thallium-SPECT and FDG-PET." Kyoto University, 2016. http://hdl.handle.net/2433/217137.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Bigatão, Marcela dos Reis. "A capacidade funcional de pacientes submetidos a neurocirurgia oncológica." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-07012016-151915/.

Full text
Abstract:
Introdução: A capacidade funcional refere-se fundamentalmente à potencialidade humana para o desempenho ocupacional, imprescindível para uma melhor qualidade de vida. O objetivo desta pesquisa, aprovada pelo Comitê de Ética em Pesquisa do HCFMRP-USP (processo no 648/2008), foi avaliar a capacidade funcional de pacientes submetidos a neurocirurgia oncológica e sua relação com a qualidade de vida. Método: Durante o período de maio/08 a abril/09 (12 meses) foram avaliados 52 sujeitos adultos de ambos os sexos; o grupo experimental teve 26 pacientes, sendo 14 com diagnóstico de meningioma (grupo1) e 12 com diagnóstico de glioma de alto grau (grupo 2); e o grupo controle teve 26 sujeitos, subdivididos em grupos: 1A (pareado com o grupo 1) e 2A (pareado com grupo 2). Foram realizados dois tipos de dinamometria - avaliação de força de preensão (Grip TrackTM Testing) e de pinça (Pinch TrackTM Testing) com equipamento computadorizado Tracker SystemTM; aplicação de protocolos internacionais validados no Brasil - Hospital Anxiety and Depression Scale HAD, Item Short-Form Health Survey - SF-36 e Health Assessment Questionnaire HAQ, no período pré-operatório e no terceiro mês de pós-operatório. Na análise estatística foram aplicados os testes Mann-Whitney, Wilcoxon e Coeficiente de Correlação de Spearman Resultados: Constatou-se que nos três primeiros meses de pós operatório houve aumento da capacidade funcional dos sujeitos dos grupos experimentais (1 e 2) e diminuição dos sintomas de ansiedade e depressão; não houve diferença significativa nos testes de força no pré e no pós operatório, mas ambos os grupos apresentam diminuição de força no membro dominante em comparação com os grupos controle. Houve correlações de forte magnitude entre os dados coletados através dos testes Grip TrackTM Testing, Pinch TrackTM Testing; protocolos: HAD, HAQ e SF-36, com rho 0,600 a 0,969. Os domínios aspecto social e emocional do instrumento de qualidade de vida mostraram uma piora no pósoperatório imediato. Esses resultados corroboram a compreensão ampliada do conceito de funcionalidade, como proposto na Classificação Internacional de Funcionalidade e Incapacidade e Saúde\" (CIF). Conclusão: A funcionalidade está diretamente relacionada com a qualidade de vida, principalmente nos aspectos psicossociais, sendo necessária compreendê-la de forma mais ampla do que funções físicas específicas, para implementar planos de tratamentos mais adequados para os sujeitos com tumor cerebral, tanto no pré como no pós operatório, com acompanhamento de uma equipe multidisciplinar.
Introduction. Functional capacity refers mainly to the potential for human occupational performance, essential for a better quality of life. This research, approved by the Committee of Ethics in Research- HCFMRP USP (in case 648/2008), was to assess the functional capacity of patients undergoing neurosurgery oncology and its relationship to quality of life. Methods. During the period of the abril/09 May/08 (12 months) were assessed 52 subjects adults of both sexes, the experimental group had 26 patients, 14 with a diagnosis of meningioma (group1) and 12 diagnosed with high grade glioma (group 2); and the control group has 26 subjects, divided into groups: 1A (paired with group 1) and 2A (paired with group 2). Were performed two types of dinamometry - evaluation of grip strength (grip TrackTM Testing) and pinch (Pinch TrackTM Testing) SystemTM Tracker with computerized equipment, application of international protocols validated in Brazil - Hospital Anxiety and Depression Scale - HAD, Item Short- Form Health Survey - SF-36 and Health Assessment Questionnaire - HAQ in the preoperative period and in the third month postoperatively. Statistical analysis using the statistical Mann-Whitney, Wilcoxon and Spearman Correlation Coefficient. Results . It was found that the first three months postoperatively increased functional capacity of the subjects of the experimental groups (1 and 2) and decrease symptoms of anxiety and depression, no significant difference in the strength tests before and after surgery but both groups have reduced strength in the dominant limb compared with control groups. There were strong correlations between the magnitude of data collected through tests Grip TrackTM Testing, Testing Pinch TrackTM; protocols: HAD, HAQ and SF-36 with rho 0.600 to 0.969. The aspect of social and emotional domains of quality of life instrument showed a worsening in the immediate postoperative period. These results support the expanded understanding of the concept of functionality, as proposed in the \"International Classification of Functioning and Disability and Health (ICF). Conclusion. The functionality is directly related to the quality of life, especially on psychosocial aspects and needed to understand it more broadly than specific physical functions, to implement plans of treatment best suited to individuals with brain tumor, both pre and postoperatively, with the accompaniment of a multidisciplinary team.
APA, Harvard, Vancouver, ISO, and other styles
10

Junior, Irineu Renzi. "Expressão dos microRNAs miR-1 e miR-133b e dos genes ACVR1C, CCL18, VGLL3, ASPN, OGDHL, BTC em meningiomas com e sem deleção do cromossomo 22q." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-23012016-113912/.

Full text
Abstract:
Introdução: Dentre os tumores primários do SNC, o meningioma é o tipo mais frequentemente diagnosticado, sendo responsável por 35,5% dos casos, considerando-se todas as faixas etárias. A gênese dos meningiomas é um processo complexo que envolve o acúmulo de alterações genéticas, sendo o evento mais conhecido a deleção no braço longo do cromossomo 22. O entendimento da iniciação e do crescimento dos meningiomas em nível molecular pode ajudar a definir novos alvos de terapia e, neste contexto, tem se destacado na última década o estudo dos microRNAs (miRNAs). Os miRNAs são uma classe de pequenos RNAs não codificadores que regulam a expressão gênica e têm um papel crucial no desenvolvimento de vários tipos de câncer. O reconhecimento do papel destes RNAs na fisiopatologia dos tumores do SNC vem ganhando destaque. O objetivo deste estudo é compreender o envolvimento da deleção do cromossomo 22q no perfil de expressão de genes e de miRNAs nos meningiomas grau I e, com isso, possibilitar uma melhor compreensão da sua natureza que permita propor alvos potenciais para novas formas de terapia molecular no futuro. Pacientes e métodos: Em um estudo prévio de nosso grupo foi feita uma análise global da expressão gênica pela metodologia de microarrays. Inicialmente para determinação dos grupos foi feita uma análise pela técnica de FISH para identificar quais amostras tinham a deleção do cromossomo 22q e por análise dos microarrays foram selecionados microRNAs e genes para validação PCR em tempo real. Em nosso estudo atual foram utilizadas 15 amostras em cada grupo: um grupo de meningiomas com deleção do cromossomo 22q, um segundo grupo de meningiomas sem deleção do cromossomo 22q e um grupo controle de 15 amostras de aracnoide normal. Os genes selecionados foram o ACVR1C, CCL18, VGLL3, ASPN, OGDHL e BTC e os miRNAs foram o miR-1 e miR-133b. Resultados e Conclusões: Os genes e microRNAs selecionados pela análise de microarray e validados por PCR em tempo real mostraram-se diferentemente expressos entre meningiomas com deleção do cromossomo 22q e meningiomas sem deleção do cromossomo 22q. Os genes ACVR1C, CCL18 e VGLL3 foram hipoexpressos em ambos os grupos de meningiomas, com deleção do cromossomo 22q e sem deleção do cromossomo 22q. O gene ASPN também foi hipoexpresso em meningiomas sem deleção do 22q quando comparado ao grupo controle. O gene OGDHL foi hiperexpresso em meningiomas sem a deleção do 22q quando comparado ao grupo controle. O gene BTC foi diferentemente expresso entre meningiomas com e sem deleção do 22q. Os microRNAs miR-1e miR-133b foram hipoexpressos em meningiomas com deleção do 22q e em mengiomas sem deleção do 22q.
Introduction: Among the primary tumors of the Nervous System, the meningioma is the most frequently diagnosed type, accounting for 35.5% of cases, considering all age groups. The genesis of meningiomas is a complex process that involves accumulation of genetic alterations, the most important event being the deletion in the long arm of chromosome 22. Understanding the initiation and growth of meningiomas at the molecular level can help developing new targets for therapy and, in this context, has been highlighted in the last decade the study of microRNAs (miRNAs). MiRNAs are a class of small non-coding RNAs which regulates gene expression and plays a crucial role in the development of many types of cancer. The recognition of their role in the pathophysiology of brain tumors has been coming into prominence. The aim of this study is to understand the involvement of chromosome 22q deletion in the expression profile of genes and miRNAs in meningiomas grade I and, with that, allow for a better understanding of its nature which may propose potential targets for new modalities of molecular therapy in the future. Patients and methods: In a previous study of our group, a global analysis by microarray methodology of genes and microRNAs was performed. Firstly, for group determination, a FISH technique analysis was done to identify which samples had the deletion of chromosome 22q and which had not and, by microarray analysis, were selected microRNAs and genes for validation by real-time PCR. In our present study 15 samples in each group were used: one group of meningiomas with deletion of chromosome 22q, a second one of meningiomas without deletion on chromosome 22q and a control group with 15 samples of normal arachnoid. The genes selected were ACVR1C, CCL18, VGLL3, ASPN, OGDHL and BTC and the miRNAs were miR-1 and miR-133b. Results and Conclusions: The genes and microRNAs selected by microarray analysis and validated by real-time PCR were differently expressed between meningiomas with deletion of chromosome 22q and meningiomas without deletion of chromosome 22q. The genes ACVR1C, CCL18 and VGLL3 were downregulated in both groups of meningiomas, either with deletion of chromosome 22q and without chromosome 22q deletion. The ASPN gene was downregulated in meningiomas without deletion of 22q when compared to the control group. The OGDHL gene was upregulated in meningiomas without deletion of 22q when compared to the control group. BTC was differentially expressed between meningiomas with and without deletion of 22q. The microRNAs miR-1 and miR-133b were downregulated in meningiomas with deletion of 22q and in mengiomas without deletion of 22q.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Meningioma"

1

Meningiomas. 2nd ed. New York: Thieme Medical, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Jeremic, Branislav, and Susanne Pitz, eds. Primary Optic Nerve Sheath Meningioma. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-77558-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Giammattei, Lorenzo, Sebastien Froelich, and Francesco Paglia. Petroclival meningioma: combined petrosal approach. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-23018-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

(Susanne), Pitz S., and SpringerLink (Online service), eds. Primary Optic Nerve Sheath Meningioma. Berlin, Heidelberg: Springer-Verlag, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Necmettin, Pamir M., Black Peter McL, and Fahlbusch Rudolf, eds. Meningiomas: A comprehensive text. Philadelphia: Saunders/Elsevier, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Solari, Domenico, Ilaria Bove, Manuel Colangelo, and Luigi Maria Cavallo. Endoscopic endonasal removal of Tuberculum Sellae Meningioma. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-51235-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

H, Lee Joung, ed. Meningiomas: Diagnosis, treatment, and outcome. London: Springer, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

M, Ammirati, and Walter G. F, eds. Surgery of skull base meningiomas. Berlin: Springer-Verlag, 1992.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

H, Lee Joung, ed. Meningiomas: Diagnosis, treatment, and outcome. London: Springer, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Al-Mefty, Ossama. Operative atlas of meningiomas. Philadelphia: Lippincott-Raven, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Meningioma"

1

Order, Stanley E., and Sarah S. Donaldson. "Meningioma." In Radiation Therapy of Benign Diseases, 196. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-58719-1_69.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Badakhshi, Harun. "Meningioma." In Image-Guided Stereotactic Radiosurgery, 81–105. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-39189-2_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Huang, Meng, Glen R. Manzano, and Allan D. Levi. "Meningioma." In Tumors of the Spinal Canal, 39–51. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55096-7_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Jo, Mi-Yeoung. "Meningioma." In Encyclopedia of Clinical Neuropsychology, 1568. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_128.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Milker-Zabel, Stefanie, and Jürgen Debus. "Meningioma." In Radiotherapy for Non-Malignant Disorders, 609–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-68943-0_35.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Patel, Nisha R., Michael L. Wong, Anthony E. Dragun, Stephan Mose, Bernadine R. Donahue, Jay S. Cooper, Filip T. Troicki, et al. "Meningioma." In Encyclopedia of Radiation Oncology, 500. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_1180.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Harris, Timothy J., Samuel T. Chao, and C. Leland Rogers. "Meningioma." In Adult CNS Radiation Oncology, 3–18. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-42878-9_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Kohan, Saeed, and M. Memet Özek. "Meningioma." In Posterior Fossa Tumors in Children, 813–21. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11274-9_55.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Jo, Mi-Yeoung. "Meningioma." In Encyclopedia of Clinical Neuropsychology, 1–2. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_128-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Sugita, Kenichiro, and Shigeaki Kobayashi. "Meningioma." In Microneurosurgical Atlas, 185–235. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-61669-3_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Meningioma"

1

Evangelista, José Ronyeryson dos Santos, Juliana Umbelino da Silva Paixão, Wanderlon Valério Lopes, Pedro Filhagosa Diverio, Paula Cristina da Silva Jordão Moreira, Paula Vieira Villar, Júlia Maria Mendonça Machado Pinheiro, and Katia Gleicielly Frigotto. "Meningiomas nas gestantes nos últimos 10 anos —revisão sistemática." In 47º Congresso da SGORJ e Trocando Ideias XXVI. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/jbg-2965-3711-2023133s1088.

Full text
Abstract:
Objetivo: Realizar uma revisão sistemática dos anos de 2012–2022 sobre meningiomas na gravidez, buscando informações sobre prevalência, idade, idade gestacional (IG), sintomas, fatores de risco, diagnóstico e tratamento. Fonte de dados: Realizou-se pesquisa bibliográfica nas bases de dados National Library of Medicine (PubMed), Scientific Electronic Library Online (SciELO) e Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Os descritores utilizados foram "meningioma AND (pregnant OR pregnancy)". Os critérios de inclusão foram artigos com texto completo disponível, publicados entre 2012 e 2022, nos idiomas português, espanhol e inglês. Artigos de revisão de literatura foram excluídos. Coleta de dados: Encontraram-se 130 artigos, dos quais 72 foram excluídos com base nos títulos, 20 foram excluídos com base nos resumos por não corresponderem ao tema, 15 eram repetidos e 2 foram excluídos por não estarem nos idiomas selecionados. Restaram 21 artigos para leitura na íntegra. Uma limitação deste estudo é que apenas um artigo se refere a casos de gestantes brasileiras. Resultados: A prevalência de meningioma em gestantes é de aproximadamente 5,6 casos por 100.000 grávidas, semelhante à prevalência em mulheres não grávidas. A progressão do meningioma durante a gravidez é geralmente lenta, mas as alterações hormonais podem estar relacionadas ao seu crescimento, principalmente devido aos receptores de progesterona. Outra hipótese é que as alterações hemodinâmicas da gravidez possam levar ao surgimento de sintomas em um meningioma já existente. No entanto, os únicos fatores de risco estabelecidos são o aumento da idade, exposição à radiação ionizante e algumas síndromes genéticas. A idade das gestantes com meningioma varia de 21 a 41 anos, com idade gestacional variando de 5 a 39 semanas (mediana de 32 semanas). Os sintomas mais comuns são cefaleia, hipoestesia, alterações visuais ou auditivas, náuseas, vômitos, letargia, convulsões e, nos casos de meningiomas espinhais, incontinência urinária e/ou fecal, e paresia dos membros. Geralmente, os sintomas surgem nos últimos trimestres da gestação, com redução pós-parto, mas podem recorrer em gestações subsequentes. O diagnóstico de meningioma durante a gravidez é feito preferencialmente por meio de ressonância magnética craniana (RMC), de preferência sem uso de contraste com gadolínio. O tratamento depende da avaliação individualizada de cada caso, sendo a observação até o pós-parto a abordagem preferencial quando possível, seguida da remoção do tumor. Se houver sinais ou sintomas neurológicos, podem ser utilizados corticosteroides, monoterapia em caso de convulsões e manitol em situações de urgência. A cesariana é a opção recomendada como primeira abordagem cirúrgica, seguida pela ressecção do tumor. No entanto, em casos de déficits neurológicos progressivos, a ressecção pode ser realizada antes do parto. Conclusão: Os casos de meningioma em gestantes são semelhantes aos casos em mulheres não grávidas. Os receptores hormonais, principalmente os de progesterona, podem desempenhar um papel importante no crescimento desses tumores. As alterações hemodinâmicas da gravidez também podem influenciar no crescimento ou surgimento de meningiomas, embora essa relação ainda não esteja totalmente esclarecida. Os sintomas mais comuns são visuais, cefaleia e convulsões, e geralmente ocorrem nos últimos trimestres da gestação, principalmente em mulheres a partir da terceira década de vida. O diagnóstico é feito por meio de RMC. O manejo do meningioma durante a gravidez requer uma abordagem multidisciplinar, considerando a saúde da mãe e do feto. A cirurgia é o tratamento de escolha, e o momento adequado depende da localização e do tamanho do tumor, dos sintomas, da idade gestacional, da viabilidade do feto e da decisão da gestante em relação à interrupção da gravidez.
APA, Harvard, Vancouver, ISO, and other styles
2

Rodrigues, Vinícius, Ádria Silva, Oscar Alves, Lília Nunes, and Maria Nunes. "Diagnóstico diferencial entre meningioma intraósseo e meningioma com hiperostose." In XXXII Congresso Brasileiro de Neurocirurgia. Thieme Revinter Publicações Ltda, 2018. http://dx.doi.org/10.1055/s-0038-1672851.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Finger, Guilherme, Daniel M. Prevedello, Bruno L. Godoy, Rodolfo F. de Carvalho, and Antonio A. do Souto. "Analysis of the Meningiomas’ Hormonal Profile in Patients with Meningioma and Breast Cancer." In 32nd Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1762353.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Bi, Wenya Linda, Samantha Hoffman, Eleanor Woodward, Joseph Driver, Sherwin Tavakol, Ayal A. Aizer, Malak Abedalthagafi, Ossama Al-Mefty, Ian F. Dunn, and Sandro Santagata. "Molecular Taxonomy of Meningioma." In 30th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1702452.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

de Almeida Rodrigues, Carlos, Carolina de Oliveira, Eloisa Slongo, Thomas Fiorio, Hariane Carvalho, Tatiana Pereira, Eduardo Pessoa Junior, et al. "Meningioma orbitário: observações clínicas." In XXXII Congresso Brasileiro de Neurocirurgia. Thieme Revinter Publicações Ltda, 2018. http://dx.doi.org/10.1055/s-0038-1672780.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Elahi, Basim M. Noor, and Abdulrazaq M. Ajlan. "Classification of Suprasellar Meningioma." In 31st Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1743785.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Weitzenberg and Merle Marie. "New Somatostatin Receptor 2 (SSTR2)-Targeted Probe for Near-Infrared (NIR) Fluorescence Guided Meningioma Surgery." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/omp.2023.om3e.2.

Full text
Abstract:
Meningioma frequently recur at the primary resection site demanding improvement of intraoperative tumor visualization. We developed NIR-fluorescent TATE-sNIR that specifically addresses SSTR2-expressing meningioma cells and confirmed its feasibility and both in vitro and in vivo.
APA, Harvard, Vancouver, ISO, and other styles
8

Fatima, Kiran, and Hammad Majeed. "Meningioma subtype classification: A survey." In 2010 International Conference on Emerging Technologies (ICET). IEEE, 2010. http://dx.doi.org/10.1109/icet.2010.5638382.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Ajlan, Abdulrazag, Basim M. Noor Elahi, Saad Alsalih, Ahmad Alroqi, Abdulaziz Alreshaid, Saud Alromaih, and Ashwag Alqurashi. "Suprasellar Meningioma: A Novel Classification." In 32nd Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1762027.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Fermino, Pedro Henrique, BRUNO DOS SANTOS SIQUEIRA, MAHONRI MORIANCUMER DE OLIVEIRA, and RODRIGO LEAL DA SILVA. "MENINGIOMA TRANSICIONAL: RELATO DE CASO." In III Congresso Brasileiro de Estudos Patológicos On-line. Revista Multidisciplinar em Saúde, 2024. http://dx.doi.org/10.51161/conbesp2024/36469.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Meningioma"

1

Arévalo-Sáenz, Alejandra, Borja Ferrández Pujante, and Fernando J. Rascón-Ramírez. Peritumoral Edema in Resected Meningiomas: Study of Factors Associated with the Variability of Postoperative Duration. Science Repository, March 2024. http://dx.doi.org/10.31487/j.scr.2024.01.05.

Full text
Abstract:
Background: It is well known that edema can persist after meningioma resection, and sometimes it is not resolved after this time. This study aimed to establish the relationship between a series of variables associated with meningioma or surgery, and the duration of postoperative edema. Methods: We conducted a retrospective study of 77 meningiomas resected at our institution between January 2016 and January 2018 with a maximum follow-up period of up to three years. The independent variables collected were demographics, tumor location, relationship with the sinuses (invasion/contact), relationship with arterial structures, deviation from the midline, volume (cm3), degree of initial edema, WHO histological classification, degree of atypia, degree of resection, previous embolization, and development of complications. The edema levels were classified according to the classification described by Ide et al. (1995): GR0, GR1, and GR2. Measurements were performed using FLAIR magnetic resonance sequences. Statistical analyses were performed using the SPSS 21. Results: Age (p=0.003), deviation from the midline (p=0.001), and tumor volume (p<0.001) were correlated with outcome using Spearman's test. Univariate analysis revealed that the localization (p=0.016), initial edema (p<0.001), degree of atypia (p=0.019), and presence of previous embolization (p=0.037) were statistically significant. In multivariate analysis, only age, initial edema, and embolization were significant independent predictors. Conclusion: These results suggest that the degree of initial edema, midline deviation, tumor volume, tumor location, degree of atypia, and previous embolization may be important predictors of postoperative edema duration.
APA, Harvard, Vancouver, ISO, and other styles
2

Ramesh, Vijaya, and Anat Stemmer-Rachamimov. Role of Merlin/NF2 in mTOR Signaling and Meningioma Growth. Fort Belvoir, VA: Defense Technical Information Center, April 2012. http://dx.doi.org/10.21236/ada566365.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Tanti, Matthew, Sarah Nevitt, Molly Yeo, William Bolton, Paul Chumas, Ryan Mathew, and Melissa Maguire. Oedema as a prognostic factor for seizures in meningioma - a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2023. http://dx.doi.org/10.37766/inplasy2023.7.0101.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Baia, Gilson S. Combinatorial Therapy Approaches for NF2-Deficient Meningiomas. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada567130.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Baia, Gilson S. Combinatorial Therapy Approaches for NF2-Deficient Meningiomas. Fort Belvoir, VA: Defense Technical Information Center, June 2013. http://dx.doi.org/10.21236/ada584501.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Lal, Anita, and Gilson S. Baia. Merlin, the Hippo Pathway, and Tumor Suppression in Meningiomas. Fort Belvoir, VA: Defense Technical Information Center, February 2009. http://dx.doi.org/10.21236/ada497595.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Meningioma' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography