Relevant bibliographies by topics / Meningitis

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Meningitis'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Meningitis"

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Intra, Jari, Davide Carcione, Roberta Maria Sala, Claudia Siracusa, Paolo Brambilla, and Valerio Leoni. "Surveillance of Bacterial Meningitis in the Italian Hospital of Desio: A Twenty-Year Retrospective Study." Applied Microbiology 4, no. 1 (March 5, 2024): 481–85. http://dx.doi.org/10.3390/applmicrobiol4010033.

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Bacterial meningitis is a severe infection with a high fatality rate, and affects children in particular. Three vaccines against the most common bacterial causatives of meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitides, exist. Monitoring the type and incidence of bacterial meningitis is important for making future prevention and control plans. In this study, we retrospectively analyzed data regarding bacterial meningitis recovered in the Italian Hospital of Desio from 2000 to 2019. Samples from a total of 128 patients were included. Streptococcus pneumoniae was the most common microorganism, isolated in 45 cases, followed by Neisseria meningitidis (14), Listeria monocytogenes (8), Streptococcus agalactiae (group B) (4), and Haemophilus influenzae type b (2). The implementation of vaccination schedules decreased the number of bacterial meningitis cases caused by H. influenzae type b, S. pneumoniae, and N. meningitidis. Considering the bacterial meningitis cases in subjects aged 0–12 years, no H. influenzae type b strain was isolated, five cases of N. meningitidis were identified before the introduction of vaccination, and seven S. pneumoniae strains were isolated before the introduction of the PCV13 vaccination. Surveillance studies allowed us to monitor changes in bacteria distribution and to guide vaccination strategies.
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Kourna Hama, Mamadou, Dam Khan, Boubou Laouali, Catherine Okoi, Abdoulaye Yam, Moussa Haladou, Archibald Worwui, et al. "Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction." Clinical Infectious Diseases 69, Supplement_2 (September 5, 2019): S133—S139. http://dx.doi.org/10.1093/cid/ciz598.

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Abstract Background Meningitis is endemic in Niger. Haemophilus influenzae type b (Hib) vaccine and the 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in 2008 and 2014, respectively. Vaccination campaign against Neisseria meningitidis serogroup A was carried out in 2010–2011. We evaluated changes in pathogen distribution using data from hospital-based surveillance in Niger from 2010 through 2016. Methods Cerebrospinal fluid (CSF) specimens from children <5 years old with suspected meningitis were tested to detect vaccine-preventable bacterial pathogens. Confirmatory identification and serotyping/grouping of Streptococcus pneumoniae, N. meningitidis, and H. influenzae were done. Antimicrobial susceptibility testing and whole genome sequencing were performed on S. pneumoniae isolates. Results The surveillance included 2580 patients with suspected meningitis, of whom 80.8% (2085/2580) had CSF collected. Bacterial meningitis was confirmed in 273 patients: 48% (131/273) was N. meningitidis, 45% (123/273) S. pneumoniae, and 7% (19/273) H. influenzae. Streptococcus pneumoniae meningitis decreased from 34 in 2014, to 16 in 2016. PCV13 serotypes made up 88% (7/8) of S. pneumoniae meningitis prevaccination and 20% (5/20) postvaccination. Neisseria meningitidis serogroup C (NmC) was responsible for 59% (10/17) of serogrouped N. meningitidis meningitis. Hib caused 67% (2/3) of the H. influenzae meningitis isolates serotyped. Penicillin resistance was found in 16% (4/25) of S. pneumoniae isolates. Sequence type 217 was the most common lineage among S. pneumoniae isolates. Conclusions Neisseria meningitidis and S. pneumoniae remain important causes of meningitis in children in Niger. The decline in the numbers of S. pneumoniae meningitis post-PCV13 is encouraging and should continue to be monitored. NmC is the predominant serogroup causing N. meningitidis meningitis.
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Rončević Filipović, Mari, Lari Gorup, Đurđica Cekinović Grbeša, Biserka Trošelj Vukić, Irena Slavuljica, Ivica Pavić, Alen Piralić, Marija Livajić, Samira Knežević, and Lucija Sušanj. "Cerebral toxocariasis." Medicina Fluminensis 57, no. 3 (September 1, 2021): 310–14. http://dx.doi.org/10.21860/medflum2021_261194.

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Cilj: Prikazati slučaj bolesnika s atipičnom kliničkom slikom toksokaroze, koja se manifestirala izoliranom afekcijom središnjeg živčanog sustava. Prikaz slučaja: Bolesnik u dobi od 55 godina liječen je u Klinici za infektivne bolesti KBC-a Rijeka zbog cerebralne toksokaroze koja se prezentirala inicijalno aneozinofilnim aseptičnim meningitisom. Klinički tijek bolesti u početku nije ukazivao na parazitarnu infekciju, već je dijagnoza postavljena nakon ponavljajućih citološko-biokemijskih i seroloških analiza cerebrospinalnog likvora i seruma. Zaključci: Cerebralna toksokaroza je rijetka bolest, a može se prezentirati i kao teški meningitis, encefalitis ili mijelitis. Prikaz slučaja bolesnika s dokazanom cerebralnom toksokarozom koja se inicijalno prezentirala kao aneozinofilni aseptični meningitis ukazuje na važnost uključivanja neurotoksokaroze u diferencijalnu dijagnozu sindroma aseptičnog meningitisa bez drugog dokazanog uzročnika.
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Claudia, Cambrea Simona, Marcas Consuela, Diaconu Simona, Mihai Raluca, Pinzaru Anca Daniela, Mangu Florin, and Mihai Larisia. "Evolution of Different Bacterial Mningoencephalitis: Series of Case Presentations and Literature Review." ARS Medica Tomitana 25, no. 3 (August 1, 2019): 142–48. http://dx.doi.org/10.2478/arsm-2019-0029.

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Abstract Bacterial meningitis is one of the most important medical emergencies, a life-threatening condition that leads to death in all the cases in untreated patients. In infants and young children, especially under 5 years old, the most encountered and severe forms are caused by Streptococcus pneumoniae, Neisseria meningitidis and Hemophilus influenzae type b. The risk of neurological impairment after an acute episode of bacterial meningitis is relatively high. Worldwide, prevention through vaccination decreased dramatically incidence and mortality related to these disease. In Romania vaccination for Neisseria meningitides is optional available for just 6 months, vaccination for Streptococcus pneumoniae by one year, and for Haemophylus influenzae type B is available over 10 years. We present evolution of a series of three cases with different bacterial meningoencephalitis with severe evolution and prolonged hospitalization. All these cases were reported in unvaccinated children for germs that cause meningitis.
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Soeters, Heidi M., Alpha Oumar Diallo, Brice W. Bicaba, Goumbi Kadadé, Assétou Y. Dembélé, Mahamat A. Acyl, Christelle Nikiema, et al. "Bacterial Meningitis Epidemiology in Five Countries in the Meningitis Belt of Sub-Saharan Africa, 2015–2017." Journal of Infectious Diseases 220, Supplement_4 (October 31, 2019): S165—S174. http://dx.doi.org/10.1093/infdis/jiz358.

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Abstract Background The MenAfriNet Consortium supports strategic implementation of case-based meningitis surveillance in key high-risk countries of the African meningitis belt: Burkina Faso, Chad, Mali, Niger, and Togo. We describe bacterial meningitis epidemiology in these 5 countries in 2015–2017. Methods Case-based meningitis surveillance collects case-level demographic and clinical information and cerebrospinal fluid (CSF) laboratory results. Neisseria meningitidis, Streptococcus pneumoniae, or Haemophilus influenzae cases were confirmed and N. meningitidis/H. influenzae were serogrouped/serotyped by real-time polymerase chain reaction, culture, or latex agglutination. We calculated annual incidence in participating districts in each country in cases/100 000 population. Results From 2015–2017, 18 262 suspected meningitis cases were reported; 92% had a CSF specimen available, of which 26% were confirmed as N. meningitidis (n = 2433; 56%), S. pneumoniae (n = 1758; 40%), or H. influenzae (n = 180; 4%). Average annual incidences for N. meningitidis, S. pneumoniae, and H. influenzae, respectively, were 7.5, 2.5, and 0.3. N. meningitidis incidence was 1.5 in Burkina Faso, 2.7 in Chad, 0.4 in Mali, 14.7 in Niger, and 12.5 in Togo. Several outbreaks occurred: NmC in Niger in 2015–2017, NmC in Mali in 2016, and NmW in Togo in 2016–2017. Of N. meningitidis cases, 53% were NmC, 30% NmW, and 13% NmX. Five NmA cases were reported (Burkina Faso, 2015). NmX increased from 0.6% of N. meningitidis cases in 2015 to 27% in 2017. Conclusions Although bacterial meningitis epidemiology varied widely by country, NmC and NmW caused several outbreaks, NmX increased although was not associated with outbreaks, and overall NmA incidence remained low. An effective low-cost multivalent meningococcal conjugate vaccine could help further control meningococcal meningitis in the region.
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Amin, Muhammad, Asim Khurshid, Mukhtar Ahmad, and Zunaira Javed. "Etiology and outcome of culture proven bacterial meningitis in children 6 to 24 months of age." Professional Medical Journal 26, no. 09 (September 10, 2019): 1451–56. http://dx.doi.org/10.29309/tpmj/2019.26.09.2562.

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Introduction: Pediatric bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and leaves some survivors with significant sequelae. More than 2/3 cases of meningitis occur in the 1st 2 years of life, owing to decreased immunity and high vascularity of the brain.This study was conducted to determine the frequency of hemophilus influenzae type b, streptococcus pneumonia and neisseria meningitidis and outcome in culture proven meningitis in children 6 months to 24 months. Study Design: Case series. Setting: Paeds Unit 1, Bahawal Victoria Hospital, Bahawalpur and Paeds Unit of District Headquarter (DHQ) Teaching Hospital, Dera Ghazi Khan. Period: 1st April 2017 to 30th September 2018. Material and Methods: A total of 220 children (110 from each center) of either sex with culture proven meningitis, aged 6 months to 24 months, were included in the study. Demographics, duration of fever, history of seizures, weight of child, vaccination status and bacteria isolated from CSF and outcome were analyzed. The outcome in the form of mortality was noted during the first 10 days of hospital stay. Results: Amongst a total of 220 children, 123 (55.9%) were male. There were 130 (59.1%) children who were less than or equal to 1 year of age. There were 154 (70.0%) children who were having a weight of 7 to 10 kg. Vaccination status was, 111 (50.5%) were fully vaccinated, 59 (26.8%) partially vaccinated and 50 (22.7%) not vaccinated. Duration of fever was, 141 (64.1%) had fever for more than 5 days. There were 139 (63.2%) children who had a history of seizures. Streptococcus pneumonia was the commonest bacteria found in 110 (50%) children followed by neisseria meningitides 53 (24.1%), H. Influenza 37 (16.8%). Overall mortality was noted in 34 (15.5%) children. Conclusion: In children with bacterial meningitis, mortality was high and most common bacteria were found to be s.pneumoniae followed by neisseria meningitidis and h.influenzae. Awareness about the empiric and directed antimicrobial therapy will help to lower the burden of morbidity and mortality related to bacterial meningitis.
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Thomas, J., and I. M. Cheshire. "Evaluation of cochlear implantation in post-meningitic adults." Journal of Laryngology & Otology 113, no. 24 (August 1999): 27–33. http://dx.doi.org/10.1017/s0022215100146067.

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AbstractMeningitis is an important cause of deafness and in some studies has been associated with poorer outcomes in adult patients following cochlear implantation. Of the first 100 adults implanted under the Midland Cochlear Implant Programme, 28 were deafened as a result of meningitis. We compare our experience with these patients with patients with a non-meningitic aetiology.A degree of cochlear ossification was a more common finding in the meningitic group. In six cases (four meningitics, two non-meningitics) ossification was encountered only during surgery, not being apparent on pre-operative radiology.The average scores achieved on auditory tests by the meningitic group were similar to those achieved by non-meningitic patients. At nine months, using only the implant, users were able to identify 54 per cent of common environmental sounds, achieved an average score of 30 words per minute on connected discourse tracking and identified an average of 42 per cent of words correctly in BKB sentences.Poorer outcomes were more commonly associated with cochlear ossification. In patients with cognitive and neurological sequelae, benefits with the implant were not always apparent in the early months, however, with intensive therapy these patients can obtain measurable sustained benefit from their implant.
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Janowski, Andrew B., and Jason G. Newland. "From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood." F1000Research 6 (January 27, 2017): 86. http://dx.doi.org/10.12688/f1000research.8533.1.

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In the past century, advances in antibiotics and vaccination have dramatically altered the incidence and clinical outcomes of bacterial meningitis. We review the shifting epidemiology of meningitis in children, including after the implementation of vaccines that target common meningitic pathogens and the introduction of intrapartum antibiotic prophylaxis offered to mothers colonized withStreptococcus agalactiae. We also discuss what is currently known about the pathogenesis of meningitis. Recent studies of the human microbiome have illustrated dynamic relationships of bacterial and viral populations with the host, which may potentiate the risk of bacterial meningitis.
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Nakamura, Tomoka, Adam L. Cohen, Stephanie Schwartz, Jason M. Mwenda, Goitom Weldegebriel, Joseph N. M. Biey, Reggis Katsande, et al. "The Global Landscape of Pediatric Bacterial Meningitis Data Reported to the World Health Organization–Coordinated Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2014–2019." Journal of Infectious Diseases 224, Supplement_3 (September 1, 2021): S161—S173. http://dx.doi.org/10.1093/infdis/jiab217.

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Abstract Background The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use. The network was established to strengthen surveillance and laboratory confirmation of meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. Methods Sentinel hospitals report cases of children &lt;5 years of age hospitalized for suspected meningitis. Laboratories report confirmatory testing results and strain characterization tested by polymerase chain reaction. In 2019, the network included 123 laboratories that follow validated, standardized testing and reporting strategies. Results From 2014 through 2019, &gt;137 000 suspected meningitis cases were reported by 58 participating countries, with 44.6% (n = 61 386) reported from countries in the WHO African Region. More than half (56.6%, n = 77 873) were among children &lt;1 year of age, and 4.0% (n = 4010) died among those with reported disease outcome. Among suspected meningitis cases, 8.6% (n = 11 798) were classified as probable bacterial meningitis. One of 3 bacterial pathogens was identified in 30.3% (n = 3576) of these cases, namely S. pneumoniae (n = 2177 [60.9%]), H. influenzae (n = 633 [17.7%]), and N. meningitidis (n = 766 [21.4%]). Among confirmed bacterial meningitis cases with outcome reported, 11.0% died; case fatality ratio varied by pathogen (S. pneumoniae, 12.2%; H. influenzae, 6.1%; N. meningitidis, 11.0%). Among the 277 children who died with confirmed bacterial meningitis, 189 (68.2%) had confirmed S. pneumoniae. The proportion of pneumococcal cases with pneumococcal conjugate vaccine (PCV) serotypes decreased as the number of countries implementing PCV increased, from 77.8% (n = 273) to 47.5% (n = 248). Of 397 H. influenzae specimens serotyped, 49.1% (n = 195) were type b. Predominant N. meningitidis serogroups varied by region. Conclusions This multitier, global surveillance network has supported countries in detecting and serotyping the 3 principal invasive bacterial pathogens that cause pediatric meningitis. Streptococcus pneumoniae was the most common bacterial pathogen detected globally despite the growing number of countries that have nationally introduced PCV. The large proportions of deaths due to S. pneumoniae reflect the high proportion of meningitis cases caused by this pathogen. This global network demonstrated a strong correlation between PCV introduction status and reduction in the proportion of pneumococcal meningitis infections caused by vaccine serotypes. Maintaining case-based, active surveillance with laboratory confirmation for prioritized vaccine-preventable diseases remains a critical component of the global agenda in public health. The World Health Organization (WHO)-coordinated Invasive Bacterial Vaccine-Preventable Disease (IB-VPD) Surveillance Network reported data from 2014 to 2019, contributing to the estimates of the disease burden and serotypes of pediatric meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis.
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Liu, Lu, Jixuan Li, Dong Huo, Zhong Peng, Ruicheng Yang, Jiyang Fu, Bojie Xu, Bo Yang, Huanchun Chen, and Xiangru Wang. "Meningitic Escherichia coli Induction of ANGPTL4 in Brain Microvascular Endothelial Cells Contributes to Blood–Brain Barrier Disruption via ARHGAP5/RhoA/MYL5 Signaling Cascade." Pathogens 8, no. 4 (November 22, 2019): 254. http://dx.doi.org/10.3390/pathogens8040254.

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Bacterial meningitis is currently recognized as one of the most important life-threatening infections of the central nervous system (CNS) with high morbidity and mortality, despite the advancements in antimicrobial treatment. The disruption of blood–brain barrier (BBB) induced by meningitis bacteria is crucial for the development of bacterial meningitis. However, the complete mechanisms involving in the BBB disruption remain to be elucidated. Here, we found meningitic Escherichia coli induction of angiopoietin-like 4 (ANGPTL4) in brain microvascular endothelial cells (BMECs) contributes to BBB disruption via ARHGAP5/RhoA/MYL5 signaling cascade, by the demonstration that ANGPTL4 was significantly upregulated in meningitis E. coli infection of BMECs as well as mice, and treatment of the recombinant ANGPTL4 protein led to an increased permeability of the BBB in vitro and in vivo. Moreover, we found that ANGPTL4 did not affect the expression of tight junction proteins involved in BBB disruption, but it increased the expression of MYL5, which was found to have a negative role on the regulation of barrier function during meningitic E. coli infection, through the activation of RhoA signaling pathway. To our knowledge, this is the first report demonstrating the disruption of BBB induced by ANGPTL4 through the ARHGAP5/RhoA/MYL5 pathway, which largely supports the involvement of ANGPTL4 during meningitic E. coli invasion and further expands the theoretical basis for the mechanism of bacterial meningitis.
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Dissertations / Theses on the topic "Meningitis"

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Lemos, Ana Paula Silva de. "Descrição de um novo clone de Neisseria meningitidis Sorogrupo C, Grande São Paulo, 1990 a 2003." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04062009-084009/.

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Infecções por Neisseria meningitidis estão associadas a altos índices de morbimortalidade no mundo. Na Região da Grande São Paulo a Doença Meningocócica (DM) causada por Neisseria meningitidis sorogrupo C começou a se tornar prevalente em 2001 , representando, em 2003, 62,7% de todos os casos de DM sorogrupados sendo que aproximadamente 88,5% dessas cepas eram não sorotipados e não sorosubtipados (C:NST:NSST). Estes dados sugeriam que um fenótipo, C: NST:NSST, tinha emergido na Grande São Paulo e, considerando-se a importância histórica da doença na região, iniciamos o presente estudo com o objetivo de esclarecer a mudança na dinâmica da DM pela determinação das características fenotípicas e genotípicas destas cepas. Para tanto, analisamos por sorotipagem, tipagem das regiões Variáveis da PorA e PorB e do gene 16S RNA ribossomal, 753 cepas de N. meningitidis C isoladas de casos de DM provenientes da Grande São Paulo, no período de 1990 a 2003. Dado a impossibilidade de caracterização do novo fenótipo pelos anticorpos monoclonais disponíveis mundialmente, objetivamos também a produção de hibridomas produtores desses anticorpos para caracterização do fenótipo C:NST:NSST. Foram selecionadas duas linhagens celulares híbridas, produtoras de anticorpos monoclonais que reconhecem as proteínas PorA e PorB deste novo fenótipo. Entre as 255 cepas de N. meningitidis C inicialmente caracterizadas como NST:NSST, 75% (n=191) tomaram-se completamente sorotipadas como 23:P1.14-6. A análise da similaridade do gene 16S RNA ribossomal das cepas analisadas demonstrou um único padrão genético, sugerindo a clonalidade deste novo fenótipo. Os dados obtidos neste trabalho, demonstram a introdução, na Região da Grande São Paulo, de um novo clone de Neisseria meningitidis C apresentando o fenótipo C:23:P1.14-6 e que está sendo responsável pelo aumento dos casos de DM causada por este sorogrupo.
Neisseria meningitidis (Men) is an important cause of morbidity and mortality and is a leading cause of bacterial meningitis and septicemia in children and young adults in Brazil. Meningococcal disease caused by MenC started becoming the most prevalent serogroup in 2001, representing 62.7% of all MD cases serogrouped in 2003 in Greater Sao Paulo and approximately 88.5% of MenC isolates were nonserotypeable and non-serosubtypeable (NST:NSST). This data suggested that a novel invasive isolate (C:NT:NSST) had emerged in GSP, and considering the historical importance of MenC disease in the region, we initiated this study to better understand the dynamics of MD looking at the phenotypic and molecular characteristics of these isolates. To accomplish this goal, we characterized 753 MenC isolates recovered during the period of 1990 to 2003 by serotyping, PorS and PorA VR typing, 16S rRNA gene typing and produced new serotyping monoclonal antibodies (MAbs) to characterize the C:NST:NSST isolates. We were able to select two hybridoma cells that recognizes PorB and PorA proteins. Among the 255 strains initially characterized as NST:NSST, 75% (n=191) of them became completely serotyped as 23:P1 .14-6. Sy 16S RNA ribossomal typing, these strains showed the same pattern suggesting strain clonality. Our data demonstrate the introduction of a new clone of Neisseria rneningitidis C presenting the phenotype C:23:P1.14-6 and that is being responsible for the increase of the cases of DM caused by this serogroup in Great Sao Paulo.
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Bita, Fouda Andre Arsene. "Effects of MenAfriVac® Introduction in the African Meningitis Belt, 2010-2017." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5978.

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Meningococcal meningitis is a burden in the African meningitis belt. Before 2010, Neisseria meningitidis serogroup A (N. meningitidis A) was the predominant pathogen causing deathly epidemics. MenAfriVac® vaccine protects against N. meningitidis A. It was introduced in 2010 into highest meningitis risk health districts. There was limited data on the effects of MenAfriVac®, mainly on the degree of relationship between N. meningitidis A and the MenAfriVac® immunization. The social ecological model was used as a theoretical framework for this study. The purpose of this quantitative study was to assess the effectiveness of MenAfriVac® from 2010 to 2017 in 21 out of 26 countries of the African meningitis belt. The four research questions contributed to establishing the effects of MenAfriVac®. An interrupted time series design and nonprobability sampling were used. Secondary data were retrieved from World Health Organization database. The binomial negative regression and Pearson’s Chi-Square tests were used. The study found that after the MenAfriVac® introduction there were 39% decline of incidence rate of the meningitis suspected cases (IRR 0.61, 95% CI 0.48 – 0.79, p < .001), a high degree of relationship between N. meningitidis A and MenAfriVac® immunization (χ2 (1) = 11039.49, p = 0.000, Phi = 0.657, P=0.000), 99% decline of the risk of N. meningitidis A (RR 0.01, 95% CI 0.08-0.013), and 99.6% decline of risk of epidemic due to N. meningitidis A (RR 0.004, 95% CI 0.001-0.016). The study demonstrated that high MenAfriVac® coverage and enhanced surveillance are pivotal to reduce the meningitis burden. Results will be used to inform policy and public health practice to reduce the meningitis cases and improve quality of live in the community.
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Atobe, Jane Harumi. "Amplificação de DNA de Neisseria meningitidis em amostras de líquido cefalorraquidiano pela reação em cadeia da polimerase-multiplex." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-11082006-115017/.

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Padronizou-se a PCR-Multiplex para a detecção do DNA de Neisseria meningitidis. Para tanto os primers escolhidos foram: RW01, DG74 e COR28 baseados na subunidade menor do ribossomo (16S rRNA) que apresenta regiões de seqüências conservadas encontradas em todas as bactérias conhecidas. Os primers RW01 e DG74 amplificaram o fragmento universal bacteriano de 370 bp e, os primers RW01 e COR28, o fragmento específico de N. meningitidis de 279 bp em uma única etapa. Os resultados obtidos nas amostras de LCR de 168 pacientes pelos métodos de cultura e PCR-Multiplex quando comparados à bacterioscopia mostraram que tal técnica apresentou alta sensibilidade (91,3%) no estudo de amostras de LCR de bacterioscopia positiva, enquanto que a cultura apresentou resultados menores (19,7%). Nas amostras de LCR com bacterioscopia negativa a sensibilidade da PCR-Multiplex (57,8%) também foi mais elevada do que da cultura (10%). Estes dados sugerem que a técnica aqui padronizada é altamente promissora para ser utilizada como método diagnóstico da meningite meningocócica, especialmente nos casos de pacientes submetidos à terapia antibiótica prévia.
The PCR-multiplex technique was standardized to detect N.meningitidis DNA. It was used universal primer for all bacteria showing sequence of minor subunit of 16S ribossome regions (RW01, DG74) by amplification of 370bp fragment and another (COR28) for specific sequence of N. meningitidis, amplifying 279bp fragment in one step. The results obtained in CSF samples of 168 patients by culture and PCR-Multiplex technique when compared with microscopy showed high sensitivity (91,3%) in samples with positive microscopy (81) to Gram negative diplococcus, however the culture presented only 19, 7% of positivity in the same samples. In other hand the CSF samples with negative bacterioscopy (67) the PCR-Multiplex sensitivity (57,8%) was higher to culture (10,0%) too. These data indicate a high sensitivity and specificity of PCR as a tool for a rapid diagnosis of meningococcal meningitis, mainly in that patient submitted to previous antibiotic therapy as in case of this work (90% of patients) besides the possibility of a rational practice of specific treatment.
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Mai, Nguyen Thi Hoang. "Pyogenic Meningitis." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524780.

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Vranjac, Alexandre. "Meningites de etiologia indeterminada no município de São Paulo, 1960 a 1977." Universidade de São Paulo, 1988. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-05012018-092602/.

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E realizado o estudo epidemiológico das meningites de etiologia indeterminada no Municlpio de São Paulo, no período de 1960 a 1977. O trabalho é apresentado em quatro partes. Na primeira parte são apresentados e discutidos os diferentes modos de diagnóstico etiológico das meningites (presuntivos e de certeza) e é enfatizada a necessidade do estudo das meningites indeterminadas. Na segunda parte é apresentado o comportamento epidemiológico da doença meningocócica no Município de São Paulo, no período 1960 a 1977. Esta apresentação é feita visando comparar e procurando verificar a influência da doença meningocócica no comportamento epidemiológico das meningites de etiologia indeterminada. Na terceira e quarta partes são apresentados os caracteres epidemiológicos das meningites de etiologia indeterminada. Inicialmente os casos são classificados em meningites indeterminadas de provavel etiologia bacteriana ou viral, utilizando-se como parâmetro para a classificação o percentual de neutrófilos no liquor. Em seguida são apresentados e analisados os comportamentos segundo variaveis da pessoa (idade e sexo), do local de residência (segundo distritos e areas homogêneas do município), do tempo (variação anual e mensal), modo diagnóstico, evolução clinica, tempo de hospitalização. O estudo mostra que entre 1972 e 1977 ocorreu no Município de São Paulo um aumento significativo de casos de meningite de etiologia indeterminada; grande parte dos casos, provavelmente, era constituída por casos de meningite meningocócica, dos quais não foi possivel a determinação etiológica. Ocorreu também, concomitantemente, um aumento significativo de meningites de provável etiologia viral. O percentual de neutrófilos no liquor (primeiro exame) em épocas epidêmicas, pode ser utilizado como parâmetro para classificacão epidemiológica meningites segundo etiologia provavelmente bacteriana ou viral.
The epidemiological behaviour of the meningitis of undetermined etiology within the Municipality of São Paulo, during the period from 1860 to 1977, is studied. The work consists of four parts. In the first part, the different forms of etiological diagnosis of meningitis (either presumptives ar certain) are submitted and discussed, as well as the need study of the undetermined meningitis. In the second part the epidemiological behaviour of the meningococcal diseases within the Municipality of São Paulo, during the period from 1960 to 1977, is submitted. Such a presentation is made with the purpose of comparison, and trying to verify the influence of the meningococcal disease on the epidemiological behaviour of the meningitis of undetermined etiology. In the third and fourth parts, the epidemiologic characters of the meningitis of undetermined etiology are submitted. At first, the cases are classified as undetermined meningitis of probable bacterial or viral etiology, using as parameter for the classification the percentile number of neutrophiles in the liquor (first examination). Then, there are submitted and analysed the behaviour as per the variables of the person (age and sex), place of residence (according to districts and homogeneous areas within the Municipality), time (annual and monthly variation), form of diagnosis, clinic evolution, and hospitalization period. It is concluded that between 1972 and 1977 there was in the Municipality of São Paulo, an epidemics of meningitis of undetermined etiology; most of the cases were, probably, constituted by cases of meningococcic meningitis, of which it was not possible to make the etiologic determination. There was, also, al the same time, an important increase of diagnosis of meningitis of probable viral etiology. The percentile number of neutrophiles in the Liquor (first examination), in epidemic times, may be used as an epidemiological parameter for the classification of the meningitis, as per the etiology, probably bacterial or viral.
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Irving, Thomas J. "Mathematical modelling of meningococcal meningitis in the African meningitis belt." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617595.

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Meningococcal meningitis is a major public health problem in an area of sub-Saharan Africa known as the meningitis belt. In this region, thousands of people fall ill each year during highly seasonal meningitis outbreaks. At frequent but unpredictable times, large epidemics of meningitis sweep the belt. Despite the gravity of the problem, much is still unknown about what drives this pattern of epidemics. The aim of this thesis is to use mathematical models to gain insights into the epidemiology of meningococcal meningitis in the meningitis belt. Firstly, several simple deterministic models are analysed. They highlight the importance of immunity following both asymptomatic carriage and invasive meningitis. For a broad range of plausible parameter values, seasonal variation of the rate of meningococcal transmission results at long, irregular intervals. Realistic sized repeated epidemics are not possible if only the ration of cases to carriers changes seasonally.
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Ramasamy, Maheshi Nirmala. "B cell responses to conjugate and polysaccharide meningococcal vaccines." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:0086ad26-89c4-4234-a02f-f0e7f50e4551.

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The primary approach to the control of meningococcal disease remains effective vaccination programmes in susceptible populations. Vaccines against serogroups A, C, W and Y offer broad protection against meningococci and both polysaccharide and conjugate quadrivalent vaccines are licensed for use in the UK. Previous studies have assessed the antibody response to meningococcal polysaccharide and conjugate vaccines, but there is limited information on the nature of the B cell response to these antigens. As part of a clinical trial using both polysaccharide (MenACWY-PS) and conjugate (MenACWY-CRM) vaccines in adult volunteers, this DPhil reports the analysis of subsets of antigen specific B-cells produced in response to either vaccine. Prior MenACWY-PS impaired the response to a subsequent dose of MenACWY-CRM. This may be due to MenACWY-PS driving terminal differentiation of antigen specific cells into plasma cells, without replenishment of the memory B cell pool. In addition, despite prior data indicating that it may act as a thymus dependent antigen, the serogroup A polysaccharide component of MenACWY-PS appears to behave in the same way as serogroup C, W & Y polysaccharide components. Antibody molecules recognise and bind to a multitude of conformational epitopes. This variability is enabled by the complexities of immunoglobulin variable domain gene recombination which can generate a vast potential repertoire of unique antibody molecules. However, the diversity of the antibody repertoire is more restricted against specific antigens and within defined B cell subsets. In this DPhil, ‘next generation’ sequencing technologies were used to investigate the diversity of the B cell variable domain before and after vaccination of adult volunteers. Individuals at baseline were found to have distinct antibody repertoires. Vaccination with a Haemophilus influenzae type b (Hib) conjugate vaccine resulted in an oligoclonal antibody response, with enrichment for Hib specific canonical antibody sequences.
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Nardy, Stella Maria Costa. "Contribuição para o estudo epidemiológico da meningite tuberculosa na Grande São Paulo." Universidade de São Paulo, 1986. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-19122017-123137/.

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O presente trabalho estuda algumas características epidemiológicas de 241 casos de Meningite tuberculosa de pessoas residentes na Grande São Paulo, nos anos de 1982 e 1983. O levantamento de casos foi realizado no Centro de Investigações de Saúde e outras fontes oficiais de informação e complementado pela visitação domiciliária que representou um recurso inestimável para o esclarecimento dos dados. Os casos foram analisados por região de residência, aspectos individuais, núcleos familiares, história da doença, hospitalização, seqüência de tratamento e conhecimento sobre a doença. Os resultados identificam condições insatisfatórias de vida na maioria da população, demora no diagnóstico por falhas assistenciais, alta letalidade hospitalar e desconhecimento do modo de transmissão e prevenção da tuberculose pela maioria das pessoas entrevistadas. O grupo de menores de 5 anos de idade foi o mais comprometido pela ocorrência de seqüelas e, a maior letalidade oi na faixa de 7-12 meses. Ao final do estudo, houve 45,7 por cento de cura, 27,8 por cento de óbito, 13,3 por cento de abandono. Em 13,2 por cento dos casos, alguns permaneciam em observação e outros desconhecidos pelo sistema de controle de notificações.
The present paper studies some epidemiological characteristics of 241 cases of tuberculous miningitis in persons living in the Great São Paulo, State of São Paulo, Brazil, in 1982 and 1983. The survey of cases was worked out at the Center of Health Investigation; other official sources have been consulted, too, being work complemented by domiciliary visitings which represented an invaluable resource for data enlightenment. The cases were analysed taking into account region of dwelling, individual aspects, familiar nucleus, disease history, hospitalization, treatment follow-up and knowledge about the disease. Results identify unsatisfactory life conditions for the majority of the population under study; delay in diagnosing the disease due to failures in assistance; high rate of hospital lethality and lack of knowledge on how tuberculosis is transmitted and prevented by the majority of the persons interviewed with. The age group of children below five years was the one most implicated in as to the occurence of the highest rate of lethality was presented by children aged 7-12 months. At the end of the study, there were 45.7 per cent of healings; 27.8 per cent of deaths; 13.3 per cent of treatment abandonment. In 13.2 per cent of the cases, some persons continued under observation and others remained unknown by the Health System of notifications.
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Beek, Diederik van de. "Bacterial meningitis in adults." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/72440.

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Weisfelt, Martijn. "Pneumococcal meningitis in adults." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/39634.

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Books on the topic "Meningitis"

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Abramovitz, Melissa. Meningitis. Farmington Hills, Mich: Lucent Books, a part of Gale, Cengage Learning, 2015.

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Hilary, Babcock, ed. Meningitis. 2nd ed. New York, NY: Chelsea House, 2010.

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Sylvia, Engdahl, ed. Meningitis. Detroit: Greenhaven Press, 2010.

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Grabowski, John F. Meningitis. San Diego, Calif: Lucent Books, 2006.

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Shmaefsky, Brian. Meningitis. Edited by Alcamo I. Edward. Philadelphia: Chelsea House Publishers, 2005.

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Shmaefsky, Brian. Meningitis. Edited by Babcock Hilary. 2nd ed. New York, NY: Chelsea House, 2010.

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Engdahl, Sylvia. Meningitis. Detroit: Greenhaven Press, 2010.

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Goldsmith, Connie. Meningitis. Minneapolis: Twenty-First Century Books, 2008.

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1951-, Rudd Peter, ed. Neonatal meningitis. London: Mac Keith Press, 1994.

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Williams, J. D. 1931 Mar.-, Burnie J, and Beecham Colloquium (8th : 1985 : London, England), eds. Bacterial meningitis. London: Academic Press, 1987.

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Book chapters on the topic "Meningitis"

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Ketunuti, Melissa, and Matthew P. Kronman. "Meningitis." In Textbook of Clinical Pediatrics, 853–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-02202-9_69.

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Bensard, Denis D., Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, et al. "Meningitis." In Encyclopedia of Intensive Care Medicine, 1381–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_838.

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Wiedemann, Anne T. "Meningitis." In Essential Infectious Disease Topics for Primary Care, 253–58. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-034-2_17.

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Pfausler, Bettina. "Meningitis." In Klinische Neurologie, 1–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-44768-0_98-1.

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Diamond, Bruce J., and Stephanie Magou. "Meningitis." In Encyclopedia of Clinical Neuropsychology, 2141–43. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_564.

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Gilbert, Patricia. "Meningitis." In The A-Z Reference Book of Childhood Conditions, 111–15. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-7098-5_27.

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Jones, Felipe, and Felipe Fregni. "Meningitis." In Neuromethods, 213–61. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7880-9_7.

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Hoff, H. C. W., M. Lakerveld-Damman, and N. van Eijkelenburg. "Meningitis." In Verpleegkundig Vademecum, 607–10. Houten: Bohn Stafleu van Loghum, 2008. http://dx.doi.org/10.1007/978-90-313-7326-0_114.

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Tønjum, Tone, Petter Brandtzæg, and Birgitta Henriques-Normark. "Meningitis." In The Prokaryotes, 401–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-30144-5_106.

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Diamond, Bruce J., and Stephanie Magou. "Meningitis." In Encyclopedia of Clinical Neuropsychology, 1–3. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-56782-2_564-4.

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Conference papers on the topic "Meningitis"

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Miyahira, Clara Kimie, and Vania Maria Sabadoto Brienze. "Comparative analysis between the profile of cerebrospinal liquid (CSF) and clinical evolution in patients with bacterial meningitis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.023.

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Background: Bacterial meningitis is a serious infection that occurs in the Central Nervous System, which presents important morbidity and mortality, mainly in children. The main bacterial agents causing meningitis in the community are Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae. Specific signs and symptoms suggest meningitis and cerebrospinal fluid analysis is the main exam leading to diagnosis. Objectives: To analyze the behavior of cerebrospinal fluid during the evolution of the patient with bacterial meningitis. Methods: A retrospective study revised the medical records of patients with bacterial meningitis confirmed by cerebrospinal fluid examination in the Base Hospital of São José do Rio Preto from January 1996 to December 2002. Results: in the 63 Patients, there were 18 cases (28.6%) of S. pneumoniae, 20 cases (31.7%) of H. influenzae, 12 cases (19%) of N.meningitides B and 13 (20.6%) cases of N. meningitidis C. In the 18 patients with pneumococcus, 10 (55.6%) were discharged and 8 (44.4%) died. In the 20 patients with HIB, only 3 (15%) died, there was no death patients with meningococcus B and C. Conclusion: There was no difference statistics in the cerebrospinal fluid of the patients who were discharged and those who died.
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Senne, Carlos, Carlos Giafferi, Márcio Vega, Daiane Salomão, and Renan Domingues. "Use of FilmArray® in the diagnosis of bacterial meningitis." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.727.

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Introduction: The Meningitis/Encephalitis FilmArray is an automated multiplex polymerase chain reaction for identifying 14 central nervous system (CNS) care agents, including viruses, Cryptococcus, and bacteria. The following bacteria are tested: E. coli K1, H. influenzae, L. monocytogenes, N. meningitidis, S. agalactiae and pneumoniae. In this study we compared the performance of FilmArray® with conventional microbiological methods for bacterial meningitis. Methods: We retrospectively evaluated data from 903 patients with CNS infection manifested by the method. Results: 42 cases were positive for bacteria, E. coli K1=2, H. influenzae=7, L. monocytogenes=5, N. meningitidis=9, S. pneumoniae=20. Of these, only 14 (33.34%) were positive with conventional microbiological methods, including culture and/or bacterioscopy. Three patients were negative on FilmArray® and positive with other methods: 2 culture positive (S. intermedius and Micrococcus) and one Gram negative. All 28 cases positive only with FilmArray® adopted a cerebrospinal fluid infection pattern suggestive of bacterial meningitis: pleocytosis with neutrophilic predominance, increased protein and lactate, and hypoglycorrhachia. Conclusion: The study confirms previous data indicating that FilmArray® increases the sensitivity of etiological diagnosis of bacterial meningitis.
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Alfaro, Marco Aurelio, Irene Ursua, Elisa Alba Ingelmo, Ana Ramos, Lucia Garcia, and Xavier Jose Delgado. "Diente por diente es meningitis. Meningitis bacteriana secundaria a infección dental." In 30 Congreso Nacional de Medicina General y de Familia. Grupo Pacífico, 2024. http://dx.doi.org/10.48158/semg24-647.

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Bobkov, G. A., M. I. Berezovskaya, M. O. Potudanskaya, and M. S. Rubel. "DIFFERENT TYPES OF DNA-NANOSENSORS VISUALIZATION." In OpenBio-2023. ИПЦ НГУ, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-47.

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Inflammation of tissues lining the brain and spinal cord is known as meningitis. Neisseria meningitidis is typically to blame for it and can be fatal within 24 hours of infection. Here we offer a rapid detection of this pathogen suitable for Point-of-care diagnostics. We used isothermal amplification and different types of multicomponent detection systems.
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Lodhi, W., and S. Shepherd. "Coccidiodal Meningitis with Hydrocephalus." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7003.

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Costa, Débhora Geny de Sousa, Tércio Luz Barbosa, Maria Arlete da Silva Rodrigues, Larissa Alves dos Santos Silva, Sharlla Layana Leite Mendes, Mylenna Maria de Brito Silva, José Clemente Flores Último, Clinton Henry Colaço Conegundes, and Benjamin Coêlho Lustosa de Araújo. "Recurrent aseptic mollaret’s meningitis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.082.

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Context: Mollaret’s meningitis is a rare disease, where there are recurrent episodes of aseptic meningitis, characterized by fever, headache, meningitis, and cerebrospinal fluid pleocytosis with Mollaret cells, and without neurological sequelae. It is characterized by episodes of illness and episodes of remission, with no detectable etiologic agent. Case report: 38-year-old man, previously healthy, with repeated cases of severe holocranial headache, associated with nausea and vomiting, without fever and with neck pain and stiff neck. The condition was repeated 9 times during the period of 1 and a half years. In the neurological examination (during the symptoms), he presented normal fundus examination, neck stiffness present, without other meningeal signs and focal motor deficits or associated cranial nerves. Extensive serum investigation (including serology, autoimmune markers, and sputum BK test) was performed, all negative. Skull CT and MRI of the skull and cervical spine with contrast during events without abnormalities. Lumbar punctures performed during this period did not show an increase in intracranial pressure on spinal manometry; CSF analyzes showed a clear and colorless appearance, pleocytosis (higher cell count 255 cells), lymphomononuclear predominance, hyperproteinorrhachia(higher value of 100 mg/dl), with normal glucose and lactate. In the CSF samples, extensive etiological investigation (broad viral panel, general bacteria search, syphilis and Mycobacterium tuberculosis, fungi and neoplastic cells) was carried out, all negative. Cisternoscintigraphy performed excluding cerebrospinal fluid fistulas. The patient evolved without neurological sequelae. Conclusions: Mollaret’s recurrent aseptic meningitis is associated with social impairment and functional limitations. Thus, further discussions on conduct and prognosis are needed.
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Freijanes, Loise Maria de Souza, Elisa Yuki Kurosawa Ueda, Paola Restum Antonio Lemaitre, and Isabela Pierotti Prado. "Tuberculous Meningitis: Literature Review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.163.

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Background: Tuberculous meningitis is the most severe form of M.tuberculosis infection, and occurs when there is an invasion of the membranes and cerebrospinal fluid by the bacteria. It develops as a complication of primary infection and reactivation in immunosuppressed. Objectives: This study aims to characterize tuberculous meningitis and bring updates. Design and setting: This is a literature review from the Escola de Medicina Souza Marques‘s students, Brazil. Methods: The used articles were published between 2012 and 2021, from the UpToDate, Scielo, PubMed, and Google Scholar databases. Results: Relevant epidemiological factors, such as HIV, and the absence of the Tuberculosis vaccine could raise the diagnosis hypothesis for the disease. Furthermore, clinical features as headaches, myalgia, fever, emesis, and sudden mood swings are also red flags. Patients should always be tested for HIV infection since mortality in these cases is about 60%. Tuberculous meningitis has a high lethality due to the delay in diagnosis and, in the absence of therapeutics, it worsens the prognosis. The complications are hydrocephalus, cranial nerve paralysis, strabismus, and coma. The diagnostic methods include CSF examination, computed tomography, magnetic resonance imaging, and GeneXpert. The treatment consists of antituberculosis therapy with glucocorticoids. Conclusions: It is essential to identify the disease and start immediate treatment, in addition to emphasizing the BCG vaccine and HIV prevention to reduce cases.
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Mak, J., and A. Mittal. "Ventriculostomy-Related Acinetobacter Meningitis." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1617.

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Sánchez, Beatriz, Laura Fernandez, María Romero, David García, Patricia Calles, and Alejandro Domínguez. "De queratitis a meningitis." In 30 Congreso Nacional de Medicina General y de Familia. Grupo Pacífico, 2024. http://dx.doi.org/10.48158/semg24-111.

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Idrissa, AA, S. Atti, RK Wasaulua, S. Kazadi, O. Guindo, G. Tonamou, I. Ciglenecki, and ME Coldiron. "Sequelae following an epidemic of meningococcal meningitis in Niger." In MSF Scientific Day International 2023. NYC: MSF-USA, 2023. http://dx.doi.org/10.57740/wg9g-dq47.

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INTRODUCTION MSF supported Niger’s Ministry of Health (MoH) in responding to a serogroup C meningococcal meningitis epidemic in Magaria and Dungass Districts in 2022. WHO’s global roadmap for defeating meningitis by 2030 emphasises appropriate care for meningitis sequelae, but this is not yet part of standard epidemic response. Meningitis sequelae in the African meningitis belt are poorly described, hampering access to rehabilitation services. To better orient future care for sequelae, we performed a follow-up survey of survivors 9 months after the 2022 epidemic. METHODS WHO case definitions were used during the epidemic. Patient-level line-lists detailing village of origin were obtained from authorities, and results of polymerase chain reaction testing on cerebrospinal fluid were integrated. Guided by village leaders, study nurses attempted to visit cases at home to assess for sequelae. Nurses administered questionnaires asking about history including seizures and subjective vision and hearing loss; and carried out physical examinations assessing anosmia, weakness, and paralysis. Data were collected tablets using REDCap software. Prevalence of sequelae among survivors was calculated. ETHICS This study was approved by the MSF Ethics Review Board and by the National Ethics Committee for Health Research of Niger. RESULTS 1001 suspected cases and 50 deaths (case fatality rate, CFR, 5.0%) originating in 230 villages were recorded on the line-lists. 469 cases (47%) had lumbar puncture, and 220 (47%) had a causative agent identified, including 192 cases of Neisseria meningitidis serogroup C (NmC) and 22 Streptococcus pneumoniae. After excluding 82 cases living in villages difficult to access, we attempted to trace 919 cases, of whom 570 (62%) were found and consented to interview. Among these cases, 49 had died (CFR 8.6%). Among the cases visited, 151 had confirmed NmC and 10 S. pneumoniae. Among the 521 surviving cases evaluated, 62 (12%) had sequelae; the most common were hearing loss (29), paralysis (16), epilepsy (9), and developmental regression (6). Among the 138 surviving confirmed cases of NmC, 25 (18%) had one or more sequelae. CONCLUSION We documented a higher CFR than reported during the epidemic, and a high burden of sequelae among survivors, particularly among those with confirmed NmC infection. To our knowledge, this is the second time that meningitis sequelae have been documented in Niger; these findings help identify priorities for integrating meningitis after-care into epidemic responses. MSF and the MoH should work to ensure linkages to long-term care and support for meningitis survivors and their caregivers. We were unable to find all cases, so the true prevalence of sequelae among survivors may differ. This follow-up survey used simple methods adapted for in-home evaluation, and formal audiometry may have led to detection of more subtle hearing loss. CONFLICTS OF INTEREST None declared
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Reports on the topic "Meningitis"

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Hernández Rodríguez, Sandy Dayan, Viviana Patricia Torne, Olivia Margarita Narváez Rumie, Constanza Cuéllar, Pilar Zambrano, and Jaime Guerrero Montilla. Brote de meningitis meningocócica en el municipio de Ciénaga, Magdalena, 2018. Instituto Nacional de Salud, January 2019. http://dx.doi.org/10.33610/01229907.2019v1n1a4.

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Antecedentes: La meningitis meningocócica es una enfermedad infecciosa grave que afecta las meninges y la médula espinal, causada principalmente por microorganismos Neisseria meningitidis. El objetivo fue describir el brote de meningitis identificado en semana epidemiológica 49 de 2018 en Ciénaga, Magdalena. Metodología: Se estimó frecuencia y porcentaje de la presentación de los casos por sexo, ubicación geográfica, caso contacto. En relación con la enfermedad: fecha de inicio de síntomas, fecha de consulta, exámenes de laboratorio, fecha de egreso y condición final. Se realizó BAC con formato preestructurado. Resultados: Se confirmaron tres casos de meningitis meningocócica en menores de cinco años de edad pertenecientes al ICBF, uno de ellos con condición final muerto, confirmado por muestra de líquido cefalorraquídeo con resultado de positivo para Neisseria meningitidis con serogrupo synD(Nm B). Se identificaron 127 contactos, se vacunaron 49 contactos directos de los tres casos y se hizo tratamiento profiláctico a 69 contactos del personal de salud. Conclusiones: La meningitis meningocócica es una enfermedad mortal de muy rápida evolución con cuadro clínico de difícil complejo por lo que se deben intensificar las acciones de prevención, control y vigilancia de esta enfermedad.
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Rojas Jiménez, José Sara. Meningitis aguda en pediatría. Facultad de Medicina Universidad de Antioquia, July 2023. http://dx.doi.org/10.59473/medudea.pc.2023.25.

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Niña de 8 años, residente en zona rural de Girardota, Antioquia. Inició en la mañana con cuadro de malestar general, inapetencia, sensación de fiebre y decaimiento. Esa misma tarde presentó un dolor de cabeza intenso, continuaba con fiebre a pesar del uso de acetaminofén, y durante la noche presentó emesis de contenido gástrico en aproximadamente 10 ocasiones.
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Anaya Perdomo, Dylan Santiago, Nelson David Galvis Garrido, and Victoria Zubiri. Enfoque clínico del paciente con meningitis. Facultad de Medicina Universidad de Antioquia, July 2023. http://dx.doi.org/10.59473/medudea.pc.2023.14.

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La meningitis es una enfermedad con distribución global, con incidencia específica en el llamado “meningitis belt” ubicado en la región subsahariana de África, en donde ocurren epidemias de enfermedad meningocócica cada 5 a 12 años (2). Se tienen reportes de la Organización Mundial de la Salud (OMS) que confirman que al año se presentan 5 millones de casos nuevos y 290.000 muertes por meningitis (2).
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Papisov, Mikhail. Viral Oncolytic Therapeutics for Neoplastic Meningitis. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada609948.

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Kuruppu, Kumudu D. Viral Oncolytic Therapeutics for Neoplastic Meningitis. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada566647.

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Kuruppu, Kumudu D. Viral Oncolytic Therapeutics for Neoplastic Meningitis. Fort Belvoir, VA: Defense Technical Information Center, July 2013. http://dx.doi.org/10.21236/ada592240.

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Papisov, Mikhail, and Betty Diamond. Viral Oncolytic Therapeutics for Neoplastic Meningitis. Fort Belvoir, VA: Defense Technical Information Center, July 2013. http://dx.doi.org/10.21236/ada600901.

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zhang, ying, fazhen zhang, yanqiu lu, mengru yang, wenling wu, and yaokai chen. Prevalence of cryptococcal meningitis in Chinese AIDS patients：results of a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2023. http://dx.doi.org/10.37766/inplasy2023.5.0041.

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Baker, Carolyn I., Christopher P. Barrozo, Margaret A. Ryan, Stephanie C. Warner, and Kevin L. Russell. Fatal Meningitis in a Healthy Young Adult Caused by Streptococcus Pnemoniae Serotypye 38, an Emerging Sertoype? Fort Belvoir, VA: Defense Technical Information Center, March 2004. http://dx.doi.org/10.21236/ada455919.

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Yu, Guocan, Wuchen Zhao, Yanqin Shen, Pengfei Zhu, and Hong Zheng. Metatagenomic Next-Generation Sequencing for diagnosis of tuberculosis Meningitis: A protocol of systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0100.

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