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Journal articles on the topic 'Menstrual fluid stem cells'

Author: Grafiati

Published: 7 June 2025

Last updated: 26 June 2025

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1

Saleena, Resheed, and V. Samson Shalini. "A Review of Menstrual Fluid Stem Cell Banking." Journal of Obstetric, Gynaecological and Birth Nursing 3, no. 1 (2024): 20–26. https://doi.org/10.5281/zenodo.14539998.

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<em>Menstrual Fluid Stem Cell Banking a Novel Approach to Regenerative Medicine. Menstrual fluid is a rich source of stem cells, which can be easily collected, isolated, and banked for future therapeutic use.</em>

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2

Goff, Adam David, Xinyue Zhang, Biju Thomas, Sally Shin Yee Ong, Anthony Atala, and Yuanyuan Zhang. "Body Fluid-Derived Stem Cells: Powering Innovative, Less-Invasive Cell Therapies." International Journal of Molecular Sciences 26, no. 9 (2025): 4382. https://doi.org/10.3390/ijms26094382.

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Stem cell therapy offers significant promise for tissue regeneration and repair. Traditionally, bone marrow- and adipose-derived stem cells have served as primary sources, but their clinical use is limited by invasiveness and low cell yield. This review focuses on body fluid-derived stem cells as an emerging, non-invasive, and readily accessible alternative. We examine stem cells isolated from amniotic fluid, peripheral blood, cord blood, menstrual fluid, urine, synovial fluid, breast milk, and cerebrospinal fluid, highlighting their unique biological properties and therapeutic potential. By comparing their characteristics and barriers to clinical translation, we propose body fluid-derived stem cells as a promising source for regenerative applications, with continued research needed to fully achieve their clinical utility.

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3

Uzieliene, I., G. Urbonaite, Z. Tachtamisevaite, A. Mobasheri, and E. Bernotiene. "The Potential of Menstrual Blood-Derived Mesenchymal Stem Cells for Cartilage Repair and Regeneration: Novel Aspects." Stem Cells International 2018 (December 3, 2018): 1–10. http://dx.doi.org/10.1155/2018/5748126.

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Menstrual blood is a unique body fluid that contains mesenchymal stem cells (MSCs). These cells have attracted a great deal of attention due to their exceptional advantages including easy access and frequently accessible sample source and no need for complex ethical and surgical interventions, as compared to other tissues. Menstrual blood-derived MSCs possess all the major stem cell properties and even have a greater proliferation and differentiation potential as compared to bone marrow-derived MSCs, making them a perspective tool in a further clinical practice. Although the potential of menstrual blood stem cells to differentiate into a large variety of tissue cells has been studied in many studies, their chondrogenic properties have not been extensively explored and investigated. Articular cartilage is susceptible to traumas and degenerative diseases, such as osteoarthritis, and has poor self-regeneration capacity and therefore requires more effective therapeutic technique. MSCs seem promising candidates for cartilage regeneration; however, no clinically effective stem cell-based repair method has yet emerged. This chapter focuses on studies in the field of menstrual blood-derived MSCs and their chondrogenic differentiation potential and suitability for application in cartilage regeneration. Although a very limited number of studies have been made in this field thus far, these cells might emerge as an efficient and easily accessible source of multipotent cells for cartilage engineering and cell-based chondroprotective therapy.

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Gallicchio, Vincent S., and Hetvi Solanki. "Stem cell based therapy for polycystic ovarian syndrome." Journal of Stem Cell Research & Therapeutics 9, no. 1 (2024): 4–7. http://dx.doi.org/10.15406/jsrt.2024.09.00165.

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Polycystic ovarian syndrome is a complex, polyfactorial condition which involves multiple genes and body systems. The development of PCOS may be attributed to several factors such as genetics, epigenetics, hyperandrogenism, insulin resistance, and environmental factors. Current medication used to treat PCOS have been shown to be ineffective and thus the development of novel therapeutics is necessary. Numerous types of stem cells can play a therapeutic role in the treatment of PCOS including mesenchymal stem cells, bone marrow stromal cells, adipose derived stem cells, menstrual blood derived mesenchymal stem cells, umbilical cord mesenchymal stem cells, amniotic fluid stem cells. Potential limitations include transplant rejection, transportation and storage difficulties, commercialization difficulty, and safety issues without monitoring.

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5

Sneha, Ann John, Gopinath E. Dr., and VineethChandy Dr. "Menstrual Blood Derived Stem Cells and their Scope in Regenerative Medicine: A Review Article." International Journal of Innovative Science and Research Technology 7, no. 5 (2022): 1345–50. https://doi.org/10.5281/zenodo.6571347.

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The menstrual fluid that is produced due to the endometrial shedding during the menstrual cycle in a women contains the blood cells that plays a major role in cell restoration and repair, these cells constitute the mesenchymal stem cells. The Men SC shave a wide range of attractive properties such as easy and frequent availability without involving any invasive and ethical complications. These cells posses all the properties of Stem cells and even have a better rate of cell proliferation and differentiation compared to the other stem cell sources. These factors have caused increased significance of these cells among the researchers. Hence they could be a source for research and clinical application.The main focus in this review include their effects in various disease like Liver Disease, Diabetes Mellitus, Stroke, Duchenne muscular dystrophy, Ovarian related disorder, Myocardial Infarction, Asherman Syndrome, Alzheimer's disease, Cutaneous Wound and provide an update on the cells in their novel form. These cells should be further investigated for their immunological properties along with various other demographic factors. Although, at present less data is available regarding the long term clinical approach, these cells could be a potential option for regenerative therapy, cartilage engineering and chondro protective differentiation

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6

Hyndavi, Trylockya Nagumantri, Nakkina Veera Naga Lalitha Nakkina, Naga Subrahmanyam S, Anusha Panchadi, Swathi Meruva, and Sagineedi Indu Harini. "Current advances in stem cell sources and therapies: a review of ongoing clinical investigations." Journal of Modern Techniques in Biology and Allied Sciences 1, no. 1 (2024): 1–3. https://doi.org/10.70604/jmtbas.v1i1.7.

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The ability of stem cells to self-renew and specialize into distinct cell lineages is very amazing. They have been thoroughly researched and used in regenerative and repair therapy throughout the last few decades. They can give rise to any cell in an embryo as well as extra-embryonic tissues, depending on their capacity for differentiation. Amniotic fluid, bone marrow, and-more recently discovered-menstrual blood and adipose tissue are among the tissues from which stem cells can be obtained. With the first bone marrow transplant, they played a pioneer role in medicine. Today, stem cell therapies are recommended for a variety of clinical problems, going beyond their conventional uses to treat genetic blood abnormalities, where they have demonstrated notable efficacy. New applications for stem cells include the treatment of neurological illnesses like Parkinson's and Alzheimer's as well as pain management. By regenerating injured neurons, stem cells may provide hope in situations of neurodegeneration. The clinical studies on the therapeutic effects and different sources of stem cell extraction are highlighted in this review, which lays the groundwork for further clinical research.

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7

Fiorelli-Arazawa, Lilian Renata, Jorge Milhem Haddad, Maria Helena Nicola, et al. "Hormonal oral contraceptive influence on isolation, Characterization and cryopreservation of mesenchymal stem cells from menstrual fluid." Gynecological Endocrinology 35, no. 7 (2019): 638–44. http://dx.doi.org/10.1080/09513590.2019.1579788.

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8

Peñailillo, Reyna, Stephanie Acuña-Gallardo, Felipe García, et al. "Mesenchymal Stem Cells-Induced Trophoblast Invasion Is Reduced in Patients with a Previous History of Preeclampsia." International Journal of Molecular Sciences 23, no. 16 (2022): 9071. http://dx.doi.org/10.3390/ijms23169071.

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Endometrial stromal cells play an important role in reproductive success, especially in implantation and placentation. Although Mesenchymal stem cells (MSCs) have been studied to assess decidualization disorders in preeclampsia (PE), their role during trophoblast invasion remains unclear. This study aims to determine: (i) whether MSCs isolated from menstrual fluid (MenSCs) from nulliparous, multiparous, and women with a previous history of preeclampsia exhibited different patterns of proliferation and migration and (ii) whether reproductive history (i.e., prior pregnancy or prior history of PE) was able to produce changes in MenSCs, thus altering trophoblast invasion capacity. MenSCs were collected from nulliparous and multiparous women without a history of PE and from non-pregnant women with a history of PE. Proliferation and migration assays were performed on MenSCs with sulforhodamine B and transwell assays, respectively. Trophoblast invasion was analyzed by culturing HTR-8/SVneo trophospheres on a matrigel overlying MenSCs for 72 h at 5% O2, simulating a 3D implantation model. A previous history of pregnancy or PE did not impact the proliferative capacity or migratory behavior of MenSCs. Following exposure to physiological endometrial conditions, MenSCs demonstrated upregulated expression of IGFBP-1 and LIF mRNA, decidualization and window of implantation markers, respectively. The mRNA expression of VIM, NANOG, and SOX2 was upregulated upon trophosphere formation. Relative to co-culture with multiparous MenSCs, co-culture with PE-MenSCs was associated with reduced trophoblast invasion. The findings of this study suggest a potential role for communication between maternal MenSCs and invading trophoblast cells during the implantation process that could be implicated in the etiology of PE.

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Peñailillo, Reyna, Victoria Velásquez, Stephanie Acuña-Gallardo, et al. "FOXM1 Participates in Trophoblast Migration and Early Trophoblast Invasion: Potential Role in Blastocyst Implantation." International Journal of Molecular Sciences 25, no. 3 (2024): 1678. http://dx.doi.org/10.3390/ijms25031678.

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Successful implantation requires coordinated migration and invasion of trophoblast cells into a receptive endometrium. Reduced forkhead box M1 (FOXM1) expression limits trophoblast migration and angiogenesis in choriocarcinoma cell lines, and in a rat model, placental FOXM1 protein expression was significantly upregulated in the early stages of pregnancy compared to term pregnancy. However, the precise role of FOXM1 in implantation events remains unknown. By analyzing mice blastocysts at embryonic day (E3.5), we have demonstrated that FOXM1 is expressed as early as the blastocyst stage, and it is expressed in the trophectoderm of the blastocyst. Since controlled oxygen tension is determinant for achieving normal implantation and placentation and a chronic hypoxic environment leads to shallow trophoblast invasion, we evaluated if FOXM1 expression changes in response to different oxygen tensions in the HTR-8/SVneo first trimester human trophoblast cell line and observed that FOXM1 expression was significantly higher when trophoblast cells were cultured at 3% O2, which coincides with oxygen concentrations in the uteroplacental interface at the time of implantation. Conversely, FOXM1 expression diminished in response to 1% O2 that resembles a hypoxic environment in utero. Migration and angiogenesis were assessed following FOXM1 knockdown and overexpression at 3% O2 and 1% O2, respectively, in HTR-8/SVneo cells. FOXM1 overexpression increased transmigration ability and tubule formation. Using a 3D trophoblast invasion model with trophospheres from HTR-8/SVneo cells cultured on a layer of MATRIGEL and of mesenchymal stem cells isolated from menstrual fluid, we observed that trophospheres obtained from 3D trophoblast invasion displayed higher FOXM1 expression compared with pre-invasion trophospheres. Moreover, we have also observed that FOXM1-overexpressing trophospheres increased trophoblast invasion compared with controls. HTR-8/SVneo-FOXM1-depleted cells led to a downregulation of PLK4, VEGF, and MMP2 mRNA expression. Our current findings suggest that FOXM1 participates in embryo implantation by contributing to trophoblast migration and early trophoblast invasion, by inducing transcription activation of genes involved in these processes. Maternal-fetal communication is crucial for trophoblast invasion, and maternal stromal cells may induce higher levels of FOXM1 in trophoblast cells.

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10

Lakhanpal, S., and B. Gupta. "Menstrual Stem cells." Journal of Gynecological Research and Obstetrics 3, no. 1 (2017): 008–10. http://dx.doi.org/10.17352/jgro.000029.

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11

Eyni, Hossein, Sadegh Ghorbani, Reza Shirazi, Leila Salari Asl, Shahram P Beiranvand, and Masoud Soleimani. "Three-dimensional wet-electrospun poly(lactic acid)/multi-wall carbon nanotubes scaffold induces differentiation of human menstrual blood-derived stem cells into germ-like cells." Journal of Biomaterials Applications 32, no. 3 (2017): 373–83. http://dx.doi.org/10.1177/0885328217723179.

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Infertility caused by the disruption or absence of germ cells is a major and largely incurable medical problem. Germ cells (i.e., sperm or egg) play a key role in the transmission of genetic and epigenetic information across generations. Generation of gametes derived in vitro from stem cells hold promising prospects which could potentially help infertile men and women. Menstrual blood-derived stem cells are a unique stem cell source. Evidence suggests that menstrual blood-derived stem cells exhibit a multi-lineage potential and have attracted extensive attention in regenerative medicine. To maintain the three-dimensional structure of natural extra cellular matrices in vitro, scaffolds can do this favor and mimic a microenvironment for cell proliferation and differentiation. According to previous studies, poly(lactic acid) and multi-wall carbon nanotubes have been introduced as novel and promising biomaterials for the proliferation and differentiation of stem cells. Some cell types have been successfully grown on a matrix containing carbon nanotubes in tissue engineering but there is no report for this material to support stem cells differentiation into germ cells lineage. This study designed a 3D wet-electrospun poly(lactic acid) and poly(lactic acid)/multi-wall carbon nanotubes composite scaffold to compare infiltration, proliferation, and differentiation potential of menstrual blood-derived stem cells toward germ cell lineage with 2D culture. Our primary data revealed that the fabricated scaffold has mechanical and biological suitable qualities for supporting and attachments of stem cells. The differentiated menstrual blood-derived stem cells tracking in scaffolds using scanning electron microscopy confirmed cell attachment, aggregation, and distribution on the porous scaffold. Based on the differentiation assay by RT-PCR analysis, stem cells and germ-like cells markers were expressed in 3D groups as well as 2D one. It seems that poly(lactic acid)/multi-wall carbon nanotubes scaffold-seeded menstrual blood-derived stem cells could be viewed as a novel, safe, and accessible construct for these cells, as they enhance germ-like generation from menstrual blood-derived stem cells.

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12

&NA;. "Amniotic Fluid Stem Cells." Lippincott's Bone and Joint Newsletter 13, no. 10 (2007): 117. http://dx.doi.org/10.1097/01.bonej.0000296703.81018.4e.

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13

Podder, Lily. "Assessment of Knowledge regarding Menstrual Blood Stem Cell Banking among Nursing Students." Nursing Journal of India CX, no. 06 (2019): 243–47. http://dx.doi.org/10.48029/nji.2019.cx601.

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Emergence of stem cell technology and the successful impact of the stem cells research has brought ray of hope to the diseased population of the world. Menstrual stem cells could offer a lot of advantages over the other stem cells as the source is easy to find. This study was conducted to assess the knowledge regarding menstrual blood stem cell banking among nursing students studying in nursing colleges of Pune, Maharashtra and to associate the knowledge with selected demographic variables. A quantitative approach with non-experimental evaluative research design was adopted; 100 samples were selected through non-probability purposive sampling technique from selected nursing education institutes of Pune city, Maharashtra. Data were collected by using a valid and reliable tool that consisted of a knowledge questionnaire regarding menstrual blood stem cell banking from the selected student nurses during March 2018 to June 2018. Paper and pencil and observation technique was used for data collection. Data was analysed by using descriptive and inferential statistics. The findings revealed that majority of the nursing students (92%) belonged to 21-25 years of age group; maximum were female (77%); 45 percent of the samples were 4th year BSc Nursing students and 30 percent were from 3rd year in BSc Nursing; 64 percent students possessed Average knowledge, 32 percent had Good knowledge and 4 percent had Poor knowledge. Regarding menstrual blood stem cells banking, there was no statistically significant association between knowledge and demographic variables at 0.05 level of significance. The advantages of the menstrual blood stem cells seem to be more as the availability of the sample though it is restricted because of the myth surrounding the use of menstrual blood.

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14

Du, Xue, Qing Yuan, Ye Qu, Yuan Zhou, and Jia Bei. "Endometrial Mesenchymal Stem Cells Isolated from Menstrual Blood by Adherence." Stem Cells International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/3573846.

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Objective. To find a convenient and efficient way to isolate MSCs from human menstrual blood and to investigate their biological characteristics, proliferative capacity, and secretion levels.Methods. MSCs were isolated from menstrual blood of 3 healthy women using adherence. Cell immunological phenotype was examined by flow cytometry; the adipogenic, osteogenic, and chondrogenic differentiation of MSCs was examined by Oil-Red-O staining, ALP staining, and Alcian Blue staining, respectively; and the secretion of cytokines, including vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and insulin-like growth factor-1 (IGF-1), was detected using enzyme-linked immunosorbent assay.Results. MB-MSCs were successfully isolated from human menstrual blood using adherence. They were positive for CD73, CD105, CD29, and CD44, but negative for CD31 and CD45. The differentiated MB-MSCs were positive for ALP staining, Oil-Red-O staining, and Alcian Blue staining. In addition, they could secrete antiapoptotic cytokines, such as VEGF, IGF-1, and HGF.Conclusion. It is feasible to isolate MSCs from human menstrual blood, thus avoiding invasive procedures and ethical controversies. Adherence could be a promising alternative to the density gradient centrifugation for the isolation of MSCs from menstrual blood.

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15

Skliutė, Giedrė, Raminta Baušytė, Veronika Borutinskaitė, et al. "Menstrual Blood-Derived Endometrial Stem Cells’ Impact for the Treatment Perspective of Female Infertility." International Journal of Molecular Sciences 22, no. 13 (2021): 6774. http://dx.doi.org/10.3390/ijms22136774.

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When looking for the causes and treatments of infertility, much attention is paid to one of the reproductive tissues—the endometrium. Therefore, endometrial stem cells are an attractive target for infertility studies in women of unexplained origin. Menstrual blood stem cells (MenSCs) are morphologically and functionally similar to cells derived directly from the endometrium; with dual expression of mesenchymal and embryonic cell markers, they proliferate and regenerate better than bone marrow mesenchymal stem cells. In addition, menstrual blood stem cells are extracted in a non-invasive and painless manner. In our study, we analyzed the characteristics and the potential for decidualization of menstrual blood stem cells isolated from healthy volunteers and women diagnosed with infertility. We demonstrated that MenSCs express CD44, CD166, CD16, CD15, BMSC, CD56, CD13 and HLA-ABC surface markers, have proliferative properties, and after induction of menstrual stem cell differentiation into epithelial direction, expression of genes related to decidualization (PRL, ESR, IGFBP and FOXO1) and angiogenesis (HIF1, VEGFR2 and VEGFR3) increased. Additionally, the p53, p21, H3K27me3 and HyperAcH4 proteins’ expression increased during MenSCs decidualization, they secrete proteins that are involved in the regulation of the actin cytoskeleton, estrogen and relaxin signaling pathways and the management of inflammatory processes. Our findings reveal the potential use of MenSCs for the treatment of reproductive disorders.

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Gargett, Caroline E., and Dharani Hapangama. "Endometrial Stem/Progenitor Cells: Prospects and Challenges." Journal of Personalized Medicine 12, no. 9 (2022): 1466. http://dx.doi.org/10.3390/jpm12091466.

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17

Gupta, PD. "Menstrual Blood Mesenchymal Stem Cells: Boon in Therapeutics." Biotechnology and Bioprocessing 2, no. 4 (2021): 01–06. http://dx.doi.org/10.31579/2766-2314/032.

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Stem cell therapy gained momentum for the past three decades in therapeutics. Alternative strategies are indispensable for the treatment of many diseases in the present scenario due to side effects of synthetic chemicals as drugs. Mesenchymal cells of different origin have been in use with good results, though ethical issues and limited availability is a drawback. Novel menstrual blood mesenchymal stems cells prove to be a wealth out of waste is a boon in therapeutics. In this review we bring a bird’s eye view of different diseases treated with menstrual blood mesenchymal stem cells with positive results. Evolution in the use of these cells more and more will be a big relief to many who suffer with side effects of drugs.

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18

Pushkala, K., and P. D. Gupta. "Menstrual Blood Mesenchymal Stem Cells: Boon In Therapeutics." Open Access Journal of Gynecology and Obstetrics 3, no. 2 (2020): 30–37. http://dx.doi.org/10.22259/2638-5244.0302004.

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19

Aylamazyan, Eduard Karpovich, Dariko Aleksandrovna Niauri, Aleksandr Mkrtichevich Gzgzyan, Lyailya Kharryasovna Dzhemlikhanova, and Yelena Olegovna Usoltseva. "The method of stem cells obtaining from menstrual blood." Journal of obstetrics and women's diseases 61, no. 5 (2012): 25–29. http://dx.doi.org/10.17816/jowd61525-29.

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20

Cananzi, Mara, and Paolo De Coppi. "CD117+amniotic fluid stem cells." Organogenesis 8, no. 3 (2012): 77–88. http://dx.doi.org/10.4161/org.22426.

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Li, Yang, Xiaoni Li, Hongxi Zhao, et al. "Efficient Induction of Pluripotent Stem Cells from Menstrual Blood." Stem Cells and Development 22, no. 7 (2013): 1147–58. http://dx.doi.org/10.1089/scd.2012.0428.

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22

Musina, R. A., A. V. Belyavski, O. V. Tarusova, E. V. Solovyova, and G. T. Sukhikh. "Endometrial mesenchymal stem cells isolated from the menstrual blood." Bulletin of Experimental Biology and Medicine 145, no. 4 (2008): 539–43. http://dx.doi.org/10.1007/s10517-008-0136-0.

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23

Zhu, Xinxin, Bruno Péault, Guijun Yan, Haixiang Sun, Yali Hu, and Lijun Ding. "Stem Cells and Endometrial Regeneration: From Basic Research to Clinical Trial." Current Stem Cell Research & Therapy 14, no. 4 (2019): 293–304. http://dx.doi.org/10.2174/1574888x14666181205120110.

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Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that Bone Marrow Mesenchymal Stem Cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. This review discusses the origin of endometrial stem cells, the characteristics and main biomarkers among five types of putative endometrial stem cells, applications of endometrium-derived stem cells and menstrual blood-derived stem cells, the association between BM-MSCs and endometrial stem cells, and progress in repairing endometrial injury.

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Mou, Xiao-zhou, Jian Lin, Jin-yang Chen, et al. "Menstrual blood-derived mesenchymal stem cells differentiate into functional hepatocyte-like cells." Journal of Zhejiang University SCIENCE B 14, no. 11 (2013): 961–72. http://dx.doi.org/10.1631/jzus.b1300081.

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Cong, Rui, and Fenglei Li. "Regular Treadmill Exercise Improves the Spinal Cord Injury Repair in a Rat Model Treated with Menstrual Blood Stem Cells and Curcumin-Loaded Nanocomposite Hydrogel: An In Vitro and In Vivo Study." Science of Advanced Materials 15, no. 7 (2023): 955–61. http://dx.doi.org/10.1166/sam.2023.4449.

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In the current study, the synergistic healing efficacy of regular treadmill exercise and administration of menstrual blood stem cells and curcumin-loaded calcium alginate hydrogel was investigated. In Vitro studies were used to characterize the hydrogel system In Vitro. Various validation methods including BBB assay, histopathological examinations, and gene expression studies were used to assess the healing efficacy of different groups. Study showed that treadmill exercise and the hydrogels loaded with both menstrual blood stem cells and curcumin significantly improved the spinal cord injury repair through upregulation of pro-healing genes.

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Rosner, Margit, Katharina Schipany, Bharanidharan Shanmugasundaram, Gert Lubec, and Markus Hengstschläger. "Amniotic Fluid Stem Cells: Future Perspectives." Stem Cells International 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/741810.

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The existence of stem cells in human amniotic fluid was reported for the first time almost ten years ago. Since this discovery, the knowledge about these cells has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely accepted as a new powerful tool for basic research as well as for the establishment of new stem-cell-based therapy concepts. It is possible to generate monoclonal genomically stable AFS cell lines harboring high proliferative potential without raising ethical issues. Many different groups have demonstrated that AFS cells can be differentiated into all three germ layer lineages, what is of relevance for both, the scientific and therapeutical usage of these cells. Of special importance for the latter is the fact that AFS cells are less tumorigenic than other pluripotent stem cell types. In this paper, we have summarized the current knowledge about this relatively young scientific field. Furthermore, we discuss the relevant future perspectives of this promising area of stem cell research focusing on the next important questions, which need to be answered.

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Davydova, D. A. "Stem cells in human amniotic fluid." Biology Bulletin 37, no. 5 (2010): 437–45. http://dx.doi.org/10.1134/s1062359010050018.

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Fauza, Dario. "Amniotic fluid and placental stem cells." Best Practice & Research Clinical Obstetrics & Gynaecology 18, no. 6 (2004): 877–91. http://dx.doi.org/10.1016/j.bpobgyn.2004.07.001.

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Hampton, Tracy. "Stem Cells Obtained From Amniotic Fluid." JAMA 297, no. 8 (2007): 795. http://dx.doi.org/10.1001/jama.297.8.795.

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Ivanitskaya, O. N., L. M. Samokhodskaya, and O. B. Panina. "Menstrual blood-derived stem cells: potential clinical and diagnostic utility." Voprosy ginekologii, akušerstva i perinatologii 19, no. 5 (2020): 86–94. http://dx.doi.org/10.20953/1726-1678-2020-5-86-94.

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Stem cells (SCs) are undifferentiated cells capable of self-renewal and differentiation into specialized cells. Particular attention is paid to mesenchymal stromal cells (MSCs) obtained from the bone marrow, adipose tissue, umbilical cord blood, and some other sources. These cells have regenerative, anti-inflammatory, and immunoregulatory potentials and, therefore, can be used for the treatment of a wide range of diseases. However, a number of technical and ethical limitations associated with the collection and clinical use of MSCs necessitates the search for additional SC sources that can be equally effective for therapeutic purposes. Menstrual blood-derived stem cells (MenSCs) are being actively studied now as a potential alternative. This article describes the immunophenotype, proliferation, migration, aging, regenerative and immunomodulatory potential, and paracrine effects of MenSCs. It also focuses on possibilities of their use for the treatment, diagnosis, and prognosis in obstetrics and gynecology. Key words: diagnostics, menstrual blood-derived stem cells, cell therapy

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Rodrigues, Melissa, Christine Blattner, and Liborio Stuppia. "Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?" International Journal of Molecular Sciences 20, no. 9 (2019): 2236. http://dx.doi.org/10.3390/ijms20092236.

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In recent years, great interest has been devoted to finding alternative sources for human stem cells which can be easily isolated, ideally without raising ethical objections. These stem cells should furthermore have a high proliferation rate and the ability to differentiate into all three germ layers. Amniotic fluid, ordinarily discarded as medical waste, is potentially such a novel source of stem cells, and these amniotic fluid derived stem cells are currently gaining a lot of attention. However, further information will be required about the properties of these cells before they can be used for therapeutic purposes. For example, the risk of tumor formation after cell transplantation needs to be explored. The tumor suppressor protein p53, well known for its activity in controlling Cell Prolif.eration and cell death in differentiated cells, has more recently been found to be also active in amniotic fluid stem cells. In this review, we summarize the major findings about human amniotic fluid stem cells since their discovery, followed by a brief overview of the important role played by p53 in embryonic and adult stem cells. In addition, we explore what is known about p53 in amniotic fluid stem cells to date, and emphasize the need to investigate its role, particularly in the context of cell tumorigenicity.

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Khaskhachikh, D. A., and V. O. Potapov. "PROLIFERATION OR REGENERATION OF THE ENDOMETRIUM?" Scientific digest of association of obstetricians and gynecologists of Ukraine, no. 1(49) (September 21, 2022): 50–58. http://dx.doi.org/10.35278/2664-0767.1(49).2022.266328.

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The article deals with the physiology of endometrial regeneration after its desquamation phase during the menstrual cycle in women, as well as an overview of studies of endometrial mesenchymal/stem cells as the main source of endometrial tissue regeneration. The processes that take place during the first phase of the menstrual cycle in their physiological essence are the processes of repair and regeneration, in contrast to proliferation, which is based on the regenerative neoplasm of tissues, which can be observed in various hyperplasias, and finally, cell proliferation is the basis of tumor growth of tissue. Regeneration of the endometrium occurs due to the division of stem paravasal cells. The unique properties of mesenchymal/stem cells, including high proliferative capacity, self-renewal, differentiation into mesodermal clones, secretion of angiogenic factors, and many other growthpromoting factors, make them useful candidates for cell therapy. Further studies of endometrial stem cells have great prospects for their effective use in practical medicine.

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Allickson, Julie, and Charlie Xiang. "Human adult stem cells from menstrual blood and endometrial tissue." Journal of Zhejiang University SCIENCE B 13, no. 5 (2012): 419–20. http://dx.doi.org/10.1631/jzus.b1200062.

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Patel, Amit N., Eulsoon Park, Michael Kuzman, Federico Benetti, Francisco J. Silva, and Julie G. Allickson. "Multipotent Menstrual Blood Stromal Stem Cells: Isolation, Characterization, and Differentiation." Cell Transplantation 17, no. 3 (2008): 303–11. http://dx.doi.org/10.3727/096368908784153922.

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Liu, Yanli, Rongcheng Niu, Fen Yang, et al. "Biological characteristics of human menstrual blood-derived endometrial stem cells." Journal of Cellular and Molecular Medicine 22, no. 3 (2017): 1627–39. http://dx.doi.org/10.1111/jcmm.13437.

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Cordeiro, Mariana Robalo, Carlota Anjinho Carvalhos, and Margarida Figueiredo-Dias. "The Emerging Role of Menstrual-Blood-Derived Stem Cells in Endometriosis." Biomedicines 11, no. 1 (2022): 39. http://dx.doi.org/10.3390/biomedicines11010039.

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The human endometrium has a complex cellular composition that is capable of promoting cyclic regeneration, where endometrial stem cells play a critical role. Menstrual blood-derived stem cells (MenSC) were first discovered in 2007 and described as exhibiting mesenchymal stem cell properties, setting them in the spotlight for endometriosis research. The stem cell theory for endometriosis pathogenesis, supported by the consensual mechanism of retrograde menstruation, highlights the recognized importance that MenSC have gained by potentially being directly related to the genesis, development and maintenance of ectopic endometriotic lesions. Meanwhile, the differences observed between MenSC in patients with endometriosis and in healthy women underlines the applicability of these cells as a putative biomarker for the early diagnosis of endometriosis, as well as for the development of targeted therapies. It is expected that in the near future MenSC will have the potential to change the way we manage this complex disease, once their long-term safety and effectiveness are assessed.

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Ge, Wei, Chao Ren, Xin Duan, et al. "Differentiation of Mesenchymal Stem Cells into Neural Stem Cells Using Cerebrospinal Fluid." Cell Biochemistry and Biophysics 71, no. 1 (2014): 449–55. http://dx.doi.org/10.1007/s12013-014-0222-z.

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Khanjani, Sayeh, Manijeh Khanmohammadi, Amir Hassan Zarnani, et al. "Efficient generation of functional hepatocyte-like cells from menstrual blood-derived stem cells." Journal of Tissue Engineering and Regenerative Medicine 9, no. 11 (2013): E124—E134. http://dx.doi.org/10.1002/term.1715.

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Manley, Hannah, James Sprinks, and Philip Breedon. "Menstrual Blood-Derived Mesenchymal Stem Cells: Women's Attitudes, Willingness, and Barriers to Donation of Menstrual Blood." Journal of Women's Health 28, no. 12 (2019): 1688–97. http://dx.doi.org/10.1089/jwh.2019.7745.

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Poslavska, O. V., I. S. Shponka, D. A. Khaskhachikh, and V. O. Potapov. "Immunohistochemical features of endometrial stem cells: morphological aspects." Morphologia 18, no. 3 (2024): 13–19. https://doi.org/10.26641/1997-9665.2024.3.13-19.

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Introduction. Menstruation is a unique biological phenomenon that occurs in a limited number of mammals such as humans and other higher primates. The endometrium changes dramatically depending on the phases of the menstrual cycle (ie, proliferative phase, secretory phase, and menstruation) and plays a critical role in the implantation of fertilized eggs. Purpose. To study the morphological and immunohistochemical features of endometrial stem cells with the study of the expression of ER, PgR, Ki67, CK PAN, PAX2, PAX8, PTEN markers that may have an impact on the development of endometrial hyperplasia. Methods. The work examines endometrial material obtained by diagnostic biopsy from 21 women with abnormal uterine bleeding (ABM). Primary monoclonal antibodies ER, PgR, CK PAN, Ki-67, PAX2, PAX8, PTEN and the UltraVision Quanto imaging system (LabVision) were used for IHC studies. Results. The endometrial glands of the deepest part of the basal layer during the menstrual cycle only weakly respond to estrogen stimulation and are completely insensitive to progesterone, which is very clearly visible in the control group (on the secretory endometrium) during an immunohistochemical study (IGH) with markers for estrogen and progesterone receptors. But the phenomenon of division of progenitor cells/stem cells can most clearly be traced to the phase of active proliferation, which also persists during hyperplastic processes in the endometrium. The expression of such specific markers as PAX2, PAX8, PTEN, of the control group was also detected in the basal layer of the hyperplastic endometrium, which confirms the homogeneity of the progenitor/stem cell phenotypes of the stroma and parenchyma. Conclusion. In the basal and functional layers of the endometrium, the difference in the expression of ER and PgR in the stroma and epithelial cells indicates a different way of activating the proliferation of reserve cells that may be involved in the processes of hyperplasia formation. The fact that the stroma actively responds to the hormonal signal of estrogen, while epithelial cells do not show sensitivity to estrogen, and the fact that the majority of stromal cells have a higher level of proliferation than the epithelium of the glands indicates a significant contribution of the influence of the stromal component to the formation of hyperplastic processes of the endometrium. The functional zone is a layer of the endometrium that undergoes cyclical changes depending on a woman's menstrual bleeding. There is a regular renewal of cells that express CK PAN, PAX2, PAX8, PTEN, which remain typical markers of epithelial cells of the endometrium. The basal layer of the endometrium responds poorly to estrogen stimulation and is almost insensitive to progesterone, but continues to express CK PAN, PAX2, PAX8, PTEN, along with reserve cells.

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Chadha, Lisa, Geetika Kashyap, and Swapnil Rahane. "Menstrual Blood Stem Cell Banking: Blessings in Disguise." Journal of Medical Evidence 5, no. 3 (2024): 238–41. http://dx.doi.org/10.4103/jme.jme_19_24.

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Abstract Menstruation is a natural part of the reproductive cycle occurring in the female body when she attains menarche. However, it was widely influenced by many socio-cultural aspects and stigma in a woman’s life. The concept has changed with the discovery of mesenchymal stem cells present in the menstrual blood, which was previously considered waste and dirty. The unique capability of the cell for its self-renewal and differentiation attracts researchers and medical professionals towards a new approach and gives them an alternate stem cell scope. Menstrual blood banking appears to be a ground-breaking, promising, cost-effective, novel and ethically acceptable substitute concept that needs to be popularised in medicine.

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Peister, Alexandra, Blaise D. Porter, Yash M. Kolambkar, Dietmar W. Hutmacher, and Robert E. Guldberg. "Osteogenic differentiation of amniotic fluid stem cells." Bio-Medical Materials and Engineering 18, no. 4-5 (2008): 241–46. http://dx.doi.org/10.3233/bme-2008-0532.

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Abdulrazzak, Hassan, Paolo De Coppi, and Pascale V Guillot. "Therapeutic Potential of Amniotic Fluid Stem Cells." Current Stem Cell Research & Therapy 8, no. 2 (2013): 117–24. http://dx.doi.org/10.2174/1574888x11308020002.

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Perin, L., S. Giuliani, D. Jin, et al. "Renal differentiation of amniotic fluid stem cells." Cell Proliferation 40, no. 6 (2007): 936–48. http://dx.doi.org/10.1111/j.1365-2184.2007.00478.x.

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Rosner, M., M. Mikula, A. Preitschopf, M. Feichtinger, K. Schipany, and M. Hengstschläger. "Neurogenic differentiation of amniotic fluid stem cells." Amino Acids 42, no. 5 (2011): 1591–96. http://dx.doi.org/10.1007/s00726-011-0929-8.

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Fallik, Dawn. "Reports on Amniotic Fluid for Stem Cells." Neurology Today 7, no. 5 (2007): 10. http://dx.doi.org/10.1097/01.nt.0000265827.73777.3a.

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Singh, Abhishek, Manish Khanna, Arun Gulati, Gautam Sinha, and Satyajeet Verma. "Sources of mesenchymal stem cells and its potential." IP International Journal of Orthopaedic Rheumatology 8, no. 1 (2022): 4–8. http://dx.doi.org/10.18231/j.ijor.2022.002.

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Mesenchymal stem cells, because of their ability to differentiate along variable cell lineages and renew themselves is a topic of interest in orthopedics for their potential role in avascular necrosis of femoral head, osteoarthritis, intervertebral disc disease, ligamentous and meniscal injuries, inducing growth in osteogenesis imperfecta and gene therapy. They also possess immunosuppressive and immunomodulatory properties. Mesenchymal stem cells can be procured from different tissue sources, such as umbilical cord, synovial tissue, breast milk, menstrual blood, adipose tissue, bone marrow, dentine pulp etc. In this review, we have attempted to make a study of the recent advances in emerging new sources of mesenchymal stem cells and their therapeutic potentials.

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Lin, Jian, Dennis Xiang, Jin-long Zhang, Julie Allickson, and Charlie Xiang. "Plasticity of human menstrual blood stem cells derived from the endometrium." Journal of Zhejiang University SCIENCE B 12, no. 5 (2011): 372–80. http://dx.doi.org/10.1631/jzus.b1100015.

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Anisimov, S. V., V. I. Zemelko, T. M. Grinchuk, and N. N. Nikolsky. "Menstrual blood stem cells as a potential source for cell therapy." Cell and Tissue Biology 7, no. 3 (2013): 201–6. http://dx.doi.org/10.1134/s1990519x13030024.

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Ferguson, Susan, Anita Mathew, Zuzana Strakova, and Asgi T. Fazleabas. "Mesenchymal Stem Cell Properties of Endometrial Cells in Baboon Menstrual Tissue." Biology of Reproduction 81, Suppl_1 (2009): 665. http://dx.doi.org/10.1093/biolreprod/81.s1.665.

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