Relevant bibliographies by topics / Mercapturic acid pathway

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Mercapturic acid pathway'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Mercapturic acid pathway"

1

Hanna, Patrick E., and M. W. Anders. "The mercapturic acid pathway." Critical Reviews in Toxicology 49, no. 10 (2019): 819–929. http://dx.doi.org/10.1080/10408444.2019.1692191.

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Kharasch, Evan D., and Carole Jubert. "Compound A Uptake and Metabolism to Mercapturic Acids and 3,3,3-Trifluoro-2-fluoromethoxypropanoic Acid during Low-flow Sevoflurane Anesthesia." Anesthesiology 91, no. 5 (1999): 1267. http://dx.doi.org/10.1097/00000542-199911000-00017.

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Background Sevoflurane is degraded during low-flow anesthesia to fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A"), which causes renal necrosis in rats but is not known to cause nephrotoxicity in surgical patients. Compound A is metabolized to glutathione S-conjugates and then to cysteine S-conjugates, which are N-acetylated to mercapturic acids (detoxication pathway), or metabolized by renal beta-lyase to reactive intermediates (toxification pathway) and excreted as 3,3,3-trifluoro-2-fluoromethoxypropanoic acid. This investigation quantified compound A metabolites in uri
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3

Goyal, R., R. Tardif, and J. Brodeur. "Influence of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromoethane, and acrylonitrile: a dose–effect study." Canadian Journal of Physiology and Pharmacology 67, no. 3 (1989): 207–12. http://dx.doi.org/10.1139/y89-035.

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Metabolic disposition of ethylene oxide, dibromoethane, and acrylonitrile in rats after acute exposure was studied by examining the relationship between dose and urinary metabolites, and by establishing the influence of a glutathione precursor, L-2-oxothiazolidine-4-carboxylic acid (OTCA), on the above relationship. Respective urinary metabolites, hydroxyethylmercapturic acid, cyanoethylmercapturic acid, thiocyanate, and ethylene glycol, were quantified to estimate the extent to which each compound was metabolized. The animals were given either ethylene oxide (0.34, 0.68, or 1.36 mmol/kg), dib
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4

Tierbach, Alena, Ksenia J. Groh, René Schönenberger, Kristin Schirmer, and Marc J. F. Suter. "Biotransformation Capacity of Zebrafish (Danio rerio) Early Life Stages: Functionality of the Mercapturic Acid Pathway." Toxicological Sciences 176, no. 2 (2020): 355–65. http://dx.doi.org/10.1093/toxsci/kfaa073.

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Abstract Zebrafish (Danio rerio) early life stages offer a versatile model system to study the efficacy and safety of drugs or other chemicals with regard to human and environmental health. This is because, aside from the well-characterized genome of zebrafish and the availability of a broad range of experimental and computational research tools, they are exceptionally well suited for high-throughput approaches. Yet, one important pharmacokinetic aspect is thus far only poorly understood in zebrafish embryo and early larvae: their biotransformation capacity. Especially, biotransformation of el
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5

Iwata, Shuzo, and Takami Maesato. "Studies on the mercapturic acid pathway in the rabbit lens." Experimental Eye Research 47, no. 3 (1988): 479–88. http://dx.doi.org/10.1016/0014-4835(88)90058-9.

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Singhal, Sharad S., Saumya Srivastava, Tamara Mirzapoiazova, David Horne, Sanjay Awasthi, and Ravi Salgia. "Targeting the mercapturic acid pathway for the treatment of melanoma." Cancer Letters 518 (October 2021): 10–22. http://dx.doi.org/10.1016/j.canlet.2021.06.004.

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7

Ou, Yueh‐Hsing, and Jen‐Kun Lin. "Biotransformation of butachlor through mercapturic acid pathway in rat tissue homogenates." Journal of Toxicology and Environmental Health 35, no. 1 (1992): 19–28. http://dx.doi.org/10.1080/15287399209531590.

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8

Moss, Elizabeth J., G. E. Neal, and D. J. Judah. "The mercapturic acid pathway metabolites of a glutathione conjugate of aflatoxin B1." Chemico-Biological Interactions 55 (1985): 139–55. http://dx.doi.org/10.1016/s0009-2797(85)80124-1.

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Yang, Y., J. Rafter, J. Å. Gustafsson, J. Sjövall, and W. Griffiths. "Letter: Differentiation of isomeric mercapturic acid pathway metabolites of benzo[a]pyrene." European Journal of Mass Spectrometry 3, no. 1 (1997): 396. http://dx.doi.org/10.1255/ejms.172.

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Singhal, Sharad S., Divya Jain, Preeti Singhal, Sanjay Awasthi, Jyotsana Singhal, and David Horne. "Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer." Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868, no. 1 (2017): 167–75. http://dx.doi.org/10.1016/j.bbcan.2017.03.009.

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Dissertations / Theses on the topic "Mercapturic acid pathway"

1

Agblor, Anita. "Donor Substrate Specificity of Bovine Kidney Gamma-Glutamyltransferase." Thesis, 2012. http://hdl.handle.net/10214/4894.

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Mammalian γ-glutamyltransferase (GGT) is a glycoprotein consisting of two subunits - a light chain and a heavy chain. The light chain contains the catalytic activity; the heavy chain anchors the protein to the membrane. GGT catalyzes the hydrolysis of the γ-glutamyl isopeptide bond of glutathione conjugates, releasing glutamic acid, or the transfer of the γ-glutamyl group to an acceptor substrate. The specificity of the enzyme for xenobiotic donor substrates has not been fully characterized. The transpeptidation activity of bovine kidney GGT was measured with glycylglycine as acceptor substrat
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Poon, James. "Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase." Thesis, 2012. http://hdl.handle.net/10214/3897.

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Following conjugation with glutathione, xenobiotics are converted into cysteinylglycine conjugates, cysteine conjugates, and, finally, mercapturic acids. The structural factors determining the activities of dipeptidases for the metabolism of toxicologically-relevant cysteinylglycine conjugates are not well understood. I purified porcine kidney cortex membrane dipeptidase (MDP) to homogeneity, via phosphatidylinositol-specific phospholipase C-mediated cleavage of the protein’s membrane anchor and cilastatin affinity chromatography. The homodimeric structure of the MDP protein was confirmed by m
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3

Sunarjo, Pius Ibrahim. "Phytochemical studies of quaking aspen (Populus tremuloides) and tulip tree (Liriodendron tulipifera) leaves and metabolism of precocene II in rats via the mercapturic acid pathway." 1985. http://catalog.hathitrust.org/api/volumes/oclc/13167344.html.

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