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Journal articles on the topic 'Mercy Hospital (Pittsburgh, Pa.)'

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Published: 4 June 2021
Last updated: 30 January 2023

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1

Casillo, Stephanie M., Anisha Venkatesh, Nallammai Muthiah, Michael M. McDowell, and Nitin Agarwal. "First Female Neurosurgeon in the United States: Dorothy Klenke Nash, MD." Neurosurgery 89, no. 4 (July 22, 2021): E223—E228. http://dx.doi.org/10.1093/neuros/nyab246.

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Abstract Dr Dorothy Klenke Nash (1898-1976) became the first female neurosurgeon in the United States in 1928 and maintained her status as the country's only female neurosurgeon until 1960. She graduated with her medical degree from the Columbia College of Physicians and Surgeons in 1927 and then trained at the Neurologic Institute of New York under Dr Byron Stookey. During her training, she contributed to the advancement of neurosurgical practice through academic research. In 1931, she married Charles B. Nash, and together they had 2 children, George (1932) and Dorothy Patricia (1937). Dr Nash became a senior surgeon at St. Margaret's Hospital in Pittsburgh in 1942. Shortly thereafter, she joined the inaugural University of Pittsburgh Department of Neurosurgery led by Dr Stuart N. Rowe and became an instructor of neurosurgery at the University of Pittsburgh School of Medicine. In acknowledgment of her advocacy for public access to services for mental health and cerebral palsy, Dr Nash was recognized as a Distinguished Daughter of Pennsylvania (1953) and honored by Mercy Hospital (1957), Bryn Mawr College (1960), and Columbia University (1968). She retired from neurosurgical practice in 1965, at which time she devoted herself to her grandchildren and her Catholic faith. She died on March 5, 1976 at the age of 77. With unwavering tenacity, Dr Nash paved the way for all women in neurosurgery.
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2

Qualman, Stephen J., Ronald Jaffe, Kevin E. Bove, and Hector Monforte-Muñoz. "Diagnosis of Hirschsprung Disease Using the Rectal Biopsy: Multi-institutional Survey." Pediatric and Developmental Pathology 2, no. 6 (November 1999): 588–96. http://dx.doi.org/10.1007/s100249900167.

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Diagnostic pathologists remain uncomfortable with the diagnosis of Hirschsprung disease (HD) via rectal (mucosal/submucosal) biopsy and with performance and interpretation of the associated acetylcholinesterase (AChE) assay. This report details the different diagnostic approaches taken by four major pediatric institutions— Children's Hospital, Columbus, OH; Children's Hospital Medical Center, Cincinnati, OH; Children's Hospital, Pittsburgh, PA; Children's Hospital, Los Angeles, CA—in confirming or excluding the presence of HD. The Columbus approach emphasizes serial morphologic examination of rectal biopsies, while Cincinnati emphasizes the primary diagnostic utility of the AChE stain. Pittsburgh and Los Angeles emphasize a detailed gross and microscopic analysis of rectal biopsies to detect both conventional HD and its more rare subtypes. The diagnostic approaches of these four institutions can be used on a complementary basis to the advantage of the general diagnostic pathologist, especially in HD cases with subtle clinical presentations. The need for careful and continual communication between the clinician and pathologist in diagnosing or excluding the presence of HD is imperative.
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Siegel, Selma F., Mamdouha Ahdab-Barmada, Silva Arslanian, and Thomas P. Foley. "Ectopic posterior pituitary tissue and paracentric inversion of the short arm of chromosome 1 in twins." European Journal of Endocrinology 133, no. 1 (July 1995): 87–92. http://dx.doi.org/10.1530/eje.0.1330087.

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Siegel SF, Ahdab-Barmada M, Arslanian S, Foley Jr TP. Ectopic posterior pituitary tissue and paracentric inversion of the short arm of chromosome 1 in twins. Eur J Endocrinol 1995;133:87–92. ISSN 0804–4643 Twin boys with hypopituitarism, hypoplasia of the anterior pituitary gland, ectopic posterior pituitary tissue and paracentric inversion of the short arm of chromosome 1 are described. The smooth appearance at the base of the median eminence and the absence of a pituitary stalk at autopsy in these boys implies that the hypopituitarism resulted from a developmental aberration. It remains to be determined if there is a causal relationship between the chromosome 1 anomaly and hypopituitarism. Selma F Siegel, Division of Endocrinology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA, 15213, USA
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4

Gregory, A. Wellenius, F. Bateson Thomas, A. Mittleman Murray, and Schwartz Joel. "PARTICULATE AIR POLLUTION IS ASSOCIATED WITH HOSPITAL ADMISSIONS FOR CONGESTIVE HEART FAILURE AMONG THE ELDERLY IN PITTSBURGH, PA." Epidemiology 14, Supplement (September 2003): S83. http://dx.doi.org/10.1097/00001648-200309001-00192.

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Howell, Joel D. "Jeanne Kisacky. Rise of the Modern Hospital: An Architectural History of Health and Healing, 1870–1940. vii + 448 pp., figs., index. Pittsburgh, Pa.: University of Pittsburgh Press, 2017. $65 (cloth)." Isis 109, no. 1 (March 2018): 197–98. http://dx.doi.org/10.1086/696593.

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6

Wald, Ellen R., Barry Dashefsky, Cindy Feidt, Darleen Chiponis, and Carol Byers. "Acute Rheumatic Fever in Western Pennsylvania and the Tristate Area." Pediatrics 80, no. 3 (September 1, 1987): 371–74. http://dx.doi.org/10.1542/peds.80.3.371.

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Acute rheumatic fever is reported to have declined and perhaps be vanishing. Prompted by the occurrence of 17 cases of acute rheumatic fever in an 18-month period in 1985 and 1986, we reviewed the records of 243 children with acute rheumatic fever who were cared for at Children's Hospital of Pittsburgh or Mercy Hospital between 1965 and 1986. Acute rheumatic fever was diagnosed using the modified Jones criteria and cases were classified by major criteria as arthritis, arthritis and carditis, carditis alone, carditis and chorea, chorea alone, and arthritis and chorea. Among the 17 recent patients, 59% had carditis, 30% had chorea, and 24% had arthritis alone. The proportion of children who had particular major manifestations was similar in the last two decades and in 1985 to 1986. The recent children with acute rheumatic fever ranged in age from 6 to 13 years with a mean and median age of 10 years. There were 16 white children and one Asian child. Only four children lived in an urban setting. When demographic features of the children were contrasted with those in the previous two decades, a decrease in the proportion of children who lived in urban areas and who were black was noted. Four children had a history of preceding sore throat but only three sought medical care; nine children had no memorable illness and four had either a nonrespiratory illness or a respiratory infection without sore throat. This resurgence of rheumatic fever serves as a reminder that a diligent approach to the diagnosis and therapy of streptococcal infections remains essential.
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7

Kamat, Vinay, Wendy L. Hecht, and Robert T. Rubin. "Influence of meal composition on the postprandial response of the pituitary–thyroid axis." European Journal of Endocrinology 133, no. 1 (July 1995): 75–79. http://dx.doi.org/10.1530/eje.0.1330075.

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Kamat V, Hecht WL, Rubin RT. Influence of meal composition on the postprandial response of the pituitary–thyroid axis. Eur J Endocrinol 1995;133:75–9. ISSN 0804–4643 Ingestion of food can result in an acute decline of serum thyrotropin (TSH) concentrations, but it is not known whether meal composition and/or stomach distension are influential. Normal men and women were given a normocaloric or hypocaloric, isobulk meal at lunch and at dinner in a randomized design. The normocaloric, but not the isobulk, meal resulted in a significant decline in serum TSH at both lunch and dinner; thyroid hormones and cortisol were not affected significantly. These findings suggest that meal composition is influential in the acute postprandial decline of serum TSH in man. A possible mechanism is food-induced elevation of somatostatin and consequent suppression of TSH secretion. Robert T Rubin, Neurosciences Research Center, Allegheny General Hospital, 320 E North Ave. Pittsburgh, PA 15212-4772, USA
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Wendy Fujita, Ayako, Lloyd Clarke, Amanda E. Kusztos, and Yohei Doi. "2282. Empiric Antimicrobial Therapy and Clinical Outcomes of Infections due to ESBL-producing Klebsiella pneumoniae." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S781—S782. http://dx.doi.org/10.1093/ofid/ofz360.1960.

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Abstract Background Currently, carbapenems are the treatment of choice for invasive infection due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E). However, clinical data supporting this practice are generated largely from cases caused by ESBL-producing Escherichia coli. We aimed to describe the empiric treatments and clinical outcomes of patients infected with ESBL-producing Klebsiella pneumoniae (ESBL-Kp) at UPMC Presbyterian Hospital in Pittsburgh, PA. Methods This retrospective study included all adult patients from inpatient admissions at UPMC Presbyterian Hospital who were diagnosed with ESBL-Kp infections. Carbapenem-resistant cases were excluded. Types of cultures included blood, respiratory, urine, and wound. Only one type of culture per patient was included. Demographic and clinical data were collected from the electronic medical records. The study was approved by the University of Pittsburgh IRB. Results One-hundred sixty-four patients had ESBL-Kp infection between September 2016 and August 2018. Excluded were those who were considered colonized by the organism and therefore not treated (n = 15); treated with non-carbapenems as definitive therapy (n = 29); or were discharged before final susceptibilities (n = 14). In total, 70 patients met inclusion criteria. Eighteen had bacteremia, 24 had pneumonia, 13 had UTI, and 12 had wound infections. Most common sources of bacteremia included catheter-associated, intra-abdominal infection, and pneumonia. Median age of patients was 62 years. Mean Charleston Comorbidity Index was 4.6. Empiric treatment was divided between three classes: BL-BLI (n = 27, 38.6%), cephalosporins (n = 21, 30%) and carbapenems (n = 18, 25.7%). Twelve patients (17.1%) died during hospitalization. Average hospital length-of-stay was 33.2 days. Conclusion Although infections with ESBL-Kp are relatively uncommon, patients have high mortality and prolonged hospitalizations. Treatment practices, including which infections are considered colonization vs. true infection, as well as choice of empirical therapy, vary widely at our institution. Data are still needed to assess mortality outcomes in patients treated empirically with carbapenems vs. non-carbapenems, particularly in high-inoculum infection sites such as pneumonia. Disclosures All authors: No reported disclosures.
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Shaikh, Nawaal, Carol Schramke, Khaled Aziz, Alexander Yu, David Jho, Stephen Karlovits, Russell Fuhrer, Cunfeng Pu, Larisa Greenberg, and Tulika Ranjan. "EPID-14. RISK FACTOR ANALYSIS AND OUTCOMES IN PATIENTS WITH HIGH GRADE GLIOMAS (HGG) MANAGED AT ALLEGHENY GENERAL HOSPITAL (AGH) IN PITTSBURGH, PA." Neuro-Oncology 18, suppl_6 (November 1, 2016): vi58. http://dx.doi.org/10.1093/neuonc/now212.240.

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10

Thota, Gopikiran. "Review of Motorcycle Related Facial Injuries Pre- and Post-2003 Pennsylvania Helmet Law Modification From 1/1998 to 8/2008 at Allegheny General Hospital, Pittsburgh, PA." Journal of Oral and Maxillofacial Surgery 67, no. 9 (September 2009): 62. http://dx.doi.org/10.1016/j.joms.2009.05.420.

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11

Unger, Scott R., Troy A. Hottle, Shakira R. Hobbs, Cassandra L. Thiel, Nicole Campion, Melissa M. Bilec, and Amy E. Landis. "Do single-use medical devices containing biopolymers reduce the environmental impacts of surgical procedures compared with their plastic equivalents?" Journal of Health Services Research & Policy 22, no. 4 (May 22, 2017): 218–25. http://dx.doi.org/10.1177/1355819617705683.

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Background While petroleum-based plastics are extensively used in health care, recent developments in biopolymer manufacturing have created new opportunities for increased integration of biopolymers into medical products, devices and services. This study compared the environmental impacts of single-use disposable devices with increased biopolymer content versus typically manufactured devices in hysterectomy. Methods A comparative life cycle assessment of single-use disposable medical products containing plastic(s) versus the same single-use medical devices with biopolymers substituted for plastic(s) at Magee-Women’s Hospital (Magee) in Pittsburgh, PA and the products used in four types of hysterectomies that contained plastics potentially suitable for biopolymer substitution. Magee is a 360-bed teaching hospital, which performs approximately 1400 hysterectomies annually. Results There are life cycle environmental impact tradeoffs when substituting biopolymers for petroplastics in procedures such as hysterectomies. The substitution of biopolymers for petroleum-based plastics increased smog-related impacts by approximately 900% for laparoscopic and robotic hysterectomies, and increased ozone depletion-related impacts by approximately 125% for laparoscopic and robotic hysterectomies. Conversely, biopolymers reduced life cycle human health impacts, acidification and cumulative energy demand for the four hysterectomy procedures. The integration of biopolymers into medical products is correlated with reductions in carcinogenic impacts, non-carcinogenic impacts and respiratory effects. However, the significant agricultural inputs associated with manufacturing biopolymers exacerbate environmental impacts of products and devices made using biopolymers. Conclusions The integration of biopolymers into medical products is correlated with reductions in carcinogenic impacts, non-carcinogenic impacts and respiratory effects; however, the significant agricultural inputs associated with manufacturing biopolymers exacerbate environmental impacts.
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12

Dabbs, David J., Molly E. Klein, Syed K. Mohsin, Raymond R. Tubbs, Yongli Shuai, and Rohit Bhargava. "High False-Negative Rate of HER2 Quantitative Reverse Transcription Polymerase Chain Reaction of the Oncotype DX Test: An Independent Quality Assurance Study." Journal of Clinical Oncology 29, no. 32 (November 10, 2011): 4279–85. http://dx.doi.org/10.1200/jco.2011.34.7963.

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Purpose HER2 (ERBB2) status is an important prognostic and predictive marker in breast carcinoma. In recent years, Genomic Health (GHI), purveyors of the Oncotype DX test, has been separately reporting HER2 by reverse transcription polymerase chain reaction (RT-PCR) to oncologists. Because of the lack of independent evaluation, this quality assurance study was undertaken to define the concordance rate between immunohistochemistry (IHC)/fluorescent in situ hybridization (FISH) and GHI RT-PCR HER2 assay. Methods All patients at three participating laboratories (Magee-Womens Hospital [Pittsburgh, PA], Cleveland Clinic [Cleveland, OH], and Riverside Methodist Hospital [Columbus, OH]) with available HER2 RT-PCR results from GHI were included in this study. All IHC-positive and equivocal patient cases were further evaluated and classified by FISH at respective laboratories. Results Of the total 843 patient cases, 784 (93%) were classified as negative, 36 (4%) as positive, and 23 (3%) as equivocal at the three institutions using IHC/FISH. Of the 784 negative patient cases, 779 (99%) were also classified as negative by GHI RT-PCR assay. However, all 23 equivocal patient cases were reported as negative by GHI. Of the 36 positive cases, only 10 (28%; 95% CI, 14% to 45%) were reported as positive, 12 (33%) as equivocal, and 14 (39%) as negative. Conclusion There was an unacceptable false-negative rate for HER2 status with GHI HER2 assay in this independent study. This could create confusion in the decision-making process for targeted treatment and potentially lead to mismanagement of patients with breast cancer if only GHI HER2 information is used.
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Salna, Michael, A. Reshad Garan, Ajay J. Kirtane, Dimitrios Karmpaliotis, Phil Green, Hiroo Takayama, Joseph Sanchez, et al. "Novel percutaneous dual-lumen cannula-based right ventricular assist device provides effective support for refractory right ventricular failure after left ventricular assist device implantation." Interactive CardioVascular and Thoracic Surgery 30, no. 4 (January 27, 2020): 499–506. http://dx.doi.org/10.1093/icvts/ivz322.

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Abstract OBJECTIVES Right heart failure after left ventricular assist device (LVAD) implantation is associated with significant morbidity and mortality. A new generation of percutaneous right ventricular assist devices (RVADs) may mitigate the need for invasive surgical RVAD implantation. The purpose of this study was to evaluate the safety and efficacy of the Protek Duo (TandemLife, Pittsburgh, PA, USA) RVAD in patients who developed severe acute right heart failure in the intensive care unit after LVAD implantation. METHODS This was a retrospective cohort study of 27 patients who received a Protek Duo after LVAD implantation from January 2016 to March 2019 at our centre. The primary outcome of interest was survival to hospital discharge. Secondary outcomes included procedural success, device-related complications and conversion to a surgical RVAD. RESULTS The median age of patients was 63 years (interquartile range 58–71), 78% were men and 78% were Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 or 2. Patients were on a median of 2 inotropes and 2 pressors prior to Protek Duo insertion. The device successfully implanted on the first attempt in all patients a median of 1 day (interquartile range 1–2) after LVAD implantation and the median duration of support was 11 days (interquartile range 7–16). Device weaning occurred in 86% of patients, with 15% in-hospital mortality. Major complications related to the device included new moderate-to-severe tricuspid regurgitation (36%), haemolysis (14%) and cannula migration (7%). Three patients (11%) required conversion to surgical RVAD. Overall survival to 1 year was 81%. CONCLUSIONS The use of the Protek Duo as a percutaneous RVAD is a safe and feasible treatment for patients who develop acute right heart failure after LVAD implantation.
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Lemon, Lara S., Lisa M. Bodnar, William Garrard, Raman Venkataramanan, Robert W. Platt, Oscar C. Marroquin, and Steve N. Caritis. "Ondansetron use in the first trimester of pregnancy and the risk of neonatal ventricular septal defect." International Journal of Epidemiology 49, no. 2 (December 20, 2019): 648–56. http://dx.doi.org/10.1093/ije/dyz255.

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Abstract Background Literature is divided regarding the risk of neonatal ventricular septal defect (VSD) associated with first trimester ondansetron use in pregnancy. Methods We evaluated the risk of VSD associated with first trimester exposure to intravenous or oral ondansetron in 33 677 deliveries at Magee–Womens Hospital in Pittsburgh, PA (2006–2014). Using log-binomial regression, we evaluated the risk: (1) in the full cohort, (2) using propensity score designs with both matching and inverse probability weighting and (3) utilizing clustered trajectory analysis evaluating the role of dose. Sensitivity analyses assessed the association between ondansetron and all recorded birth defects in aggregate. Results A total of 3733 (11%) pregnancies were exposed to ondansetron in the first trimester (dose range: 2.4–1008 mg). Ondansetron was associated with increased risk of VSD with risk ratios ranging from 1.7 [95% confidence interval (CI) 1.0–2.9] to 2.1 (95% CI 1.1–4.0) across methods. Risks correspond to one additional VSD for approximately every 330 pregnancies exposed in the first trimester. The association was dose-dependent with increased risk in women receiving highest cumulative doses compared with lowest doses [adjusted risk ratio: 3.2 (95% CI 1.0–9.9)]. The association between ondansetron and congenital malformations was diluted as the outcome included additional birth defects. Conclusions First trimester ondansetron use is associated with an increased risk of neonatal VSD potentially driven by higher doses. This risk should be viewed in the context of risks attributable to severe untreated nausea and vomiting of pregnancy.
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Isaksen, Christina Vogt, Rigmor Austgulen, Lisa Chedwick, Pål Romundstad, Lars Vatten, and Catherine Craven. "Maternal Smoking, Intrauterine Growth Restriction, and Placental Apoptosis." Pediatric and Developmental Pathology 7, no. 5 (September 2004): 433–42. http://dx.doi.org/10.1007/s10024-004-0105-1.

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Pregnant women who smoke are at greater risk of delivering a growth-restricted infant than nonsmoking mothers. We wanted to see if apoptosis could be involved in the mechanisms behind smoke-induced growth restriction, and our aim was to compare apoptosis in the placenta of smoking mothers giving birth to growth-restricted infants and nonsmoking mothers with infants of appropriate weight. The project was conducted at the Magee—Womens Hospital and Magee—Womens Research Institute, University of Pittsburgh, PA. Histological sections from 20 placentas were selected from smoking mothers who had given birth to small-for-gestational-age infants (birth weight ≤ 2 SD). The controls were gestational-age matched nonsmoking mothers with infants having appropriate-for-gestational-age weight. The TUNEL method was used to demonstrate DNA fragmentation in nuclei, and a monoclonal antibody M30, specific for a neo-epitope on cytokeratin 18, was used to identify apoptotic epithelial cells. The positive nuclei (TUNEL) and positive cells (M30-positive cytoplasm) were counted blindly both in villous tissue and in decidual/basal plate tissue. M30-positive cells in villous tissues were significantly increased in placentas from smoking mothers compared to nonsmoking mothers. When evaluated by the TUNEL method, the difference between the two groups of women was not significant. Our study shows that apoptosis was increased in the placentas of smoking mothers with growth-restricted infants. The difference between the two groups was mainly in the syncytiotrophoblast layer and in connection with perivillous fibrin deposition. Cigarette smoke with reduction in blood flow has previously been shown to increase apoptosis, and it is possible that this could be one of the mechanisms playing a role in the growth restriction.
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Larkin, L., S. Mckenna, T. Pyne, S. Gallagher, L. Glynn, A. Fraser, B. A. Esbensen, and N. Kennedy. "POS1497-HPR FEASIBILITY OF A PHYSIOTHERAPIST LED, BEHAVIOUR CHANGE INTERVENTION TO IMPROVE PHYSICAL ACTIVITY IN PEOPLE WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1093.1–1094. http://dx.doi.org/10.1136/annrheumdis-2022-eular.407.

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BackgroundPhysical activity (PA) is an important component in the management of people with rheumatoid arthritis (RA) (1). Interventions incorporating Behaviour Change (BC) theory are needed to target physically inactive people with RA. The study Physiotherapist-led Intervention to Promote Physical Activity in Rheumatoid Arthritis (PIPPRA) was designed using the Behaviour Change Wheel (BCW) and a pilot study of feasibility undertaken (ClinicalTrials.gov Identifier: NCT03644160).ObjectivesTo obtain reliable estimates regarding recruitment rates; participant retention; protocol adherence and possible adverse events, and to producing estimates of the potential effect sizes of the BC intervention on changes in outcomes of physical activity; fatigue; disability and quality of life.MethodsParticipants were recruited at University Hospital (UH) rheumatology clinics and randomly assigned to control group (physical activity information leaflet) or intervention group (four BC physiotherapy sessions in eight weeks). Inclusion criteria were diagnosis of RA (ACR/EULAR 2010 classification criteria), aged 18+ years and classified as insufficiently physically active. Ethical approval was obtained from the UH research ethics committee. Participants were assessed at baseline (T0), 8-weeks (T1), and 24-weeks (T2). Descriptive statistics and t-tests were used to analyse the data with SPSS v22.Results320 participants were identified through chart review with direct contact then with people meeting the inclusion criteria at rheumatology clinics. Of the clinic attendees n=183 (57%) were eligible to participate and n=58 (55%) of those consented to participate. The recruitment rate was 6.4 per month and refusal rate was 59%. Due to impact of COVID-19 on the study n=25 (43%) participants completed the study (n=11 (44%) in intervention and n=14 (56%) in control). Of the 25, n= 23 (92%) were female, mean age was 60 years (sd 11.5). Intervention group participants completed 100% of BC sessions 1 & 2, 88% session 3 and 81% session 4. No serious adverse events were reported. Secondary outcome measures data is Table 1.Table 1.Mean (sd) for secondary outcome measures in PIPPRA feasibility studyOutcomes and instrumentsInterventionControlBaseline Mean (sd)Time 1 Mean (sd)Time 2 Mean (sd)Baseline Mean (sd)Time 1 Mean (sd)Time 2 Mean (sd)Physical Activity – self report (YPAS1)146.27 (193.73)120.88 (70.80)132.00 (70.65)91.75 (85.86)58.03 (50.61)124.31 (69.75)Physical Activity – objective (Step Count)32,616.9132,190.0027,793.3330,476.1542,117.2534,288.77(11,415.85)(9,291.57)(7,426.92)(12,642.97)(21,714.67)(17,677.90)Pain (VAS2)4.184.904.503.715.104.79(2.40)(1.91)(1.90)(2.55)(2.77)(4.50)Disability (HAQDI3)0.850.941.030.710.711.52(0.57)(0.57)(0.65)(0.56)(0.52)(0.69)Fatigue (BRAF MDQ4)18.1814.82 (13.15)18.55 (11.84)15.71 (12.29)13.93 (15.27)20.21 (10.85)(8.98)Psychological Constructs (TPB5)22.0019.91 (7.76)20.27 (8.63)21.79 (5.67)15.50 (11.43)25.36 (6.86)(4.84)Quality of Life (RA QoL6)15.1814.73 (7.23)17.09 (7.33)18.4311.50 (10.02)14.86 (6.47)(6.08)(5.06)Sleep (PSQI7)11.558.509.9110.219.0910.14(3.56)(3.27)(3.62)(3.47)(4.32)(4.42)1YPAS – Yale Physical Activity Scale2VAS – Visual Analogue Scale3HAQDI – Health Assessment Questionnaire Disability Index4BRAF MDQ - Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire5TPB – Theory of Planned Behaviour Questionnaire6RA QoL – Rheumatoid Arthritis Quality of Life Scale7PSQI – Pittsburgh Sleep Quality IndexConclusionThe PIPPRA study designed using the BCW to improve promote physical activity was feasible and safe. This pilot study provides a framework for larger intervention studies and based on these findings a fully powered trial is recommended.References[1]Rausch Osthoff A, Niedermann K, Braun J, et al. (2018) EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Annals of the Rheumatic Diseases 77:1251-1260.Disclosure of InterestsNone declared
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"Poster 64 hereditary motor neuropathy in a man of Italian descent: A case report. Gary Goldberg, MD (Pittsburgh Mercy Health Syst, Pittsburgh, PA); Monica J. Carrion, MD, e-mail: ggoldberg@mercy.pmhs.org." Archives of Physical Medicine and Rehabilitation 85, no. 9 (September 2004): e22. http://dx.doi.org/10.1016/j.apmr.2004.07.125.

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"Advancing Practice, Instruction, and Innovation Through Informatics (APIII 2006): Scientific Session Presentation Abstracts and Scientific Poster Session Abstracts." Archives of Pathology & Laboratory Medicine 131, no. 5 (May 1, 2007): 805–21. http://dx.doi.org/10.5858/2007-131-805-apiait.

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Abstract Scientific session presentations (http://apiii.upmc.edu/abstracts/sci_schedule.html) and scientific poster sessions (http://apiii.upmc.edu/abstracts/eposter.html) were conducted at the 11th annual international conference on Advancing Practice, Instruction, and Innovation Through Informatics (APIII 2006) on August 15–18, 2006, at the Sheraton Vancouver Wall Centre, located in Vancouver, British Columbia, Canada. One of the course directors was Michael J. Becich, MD, PhD, professor of pathology and information sciences and telecommunications, chairman of the Department of Biomedical Informatics at the University of Pittsburgh, Pittsburgh, Pa. Also serving as course directors were John R. Gilbertson, MD, director of Pathology Informatics, Case Western University, Cleveland, Ohio; Walter Henricks, MD, director of Pathology Informatics, The Cleveland Clinic Foundation, Cleveland, Ohio; and Bruce McManus, MD, PhD, professor and codirector, The iCAPTURE Centre, University of British Columbia–St Paul's Hospital, Vancouver, Canada.
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"Cryosurgery for hepatic metastases other than colorectal adenocarcinoma . Department of Surgery, Allegheny General Hospital, Pittsburgh, PA, USA." Hepatology 22, no. 4 (October 1995): A147. http://dx.doi.org/10.1016/0270-9139(95)94311-0.

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Parmar, Arpita, E. Ann Yeh, Daphne J. Korczak, Shelly K. Weiss, Zihang Lu, Allison Zweerink, Alene Toulany, Brian J. Murray, and Indra Narang. "Depressive symptoms, sleep patterns, and physical activity in adolescents with narcolepsy." Sleep 42, no. 8 (May 9, 2019). http://dx.doi.org/10.1093/sleep/zsz111.

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AbstractStudy ObjectivesTo evaluate the association between depressive symptoms, sleep patterns (duration and quality), excessive daytime sleepiness (EDS), and physical activity (PA) in adolescents with narcolepsy.MethodsThis cross-sectional study included adolescents (ages 10–18 years) with narcolepsy attending a tertiary care facility (The Hospital for Sick Children, Toronto, Canada). Adolescents with narcolepsy completed questionnaires evaluating depressive symptoms (Children’s Depression Inventory-2nd edition [CDI-2]), sleep quality (Pittsburgh Sleep Quality Index), EDS (Epworth Sleepiness Scale), and PA (Godin Leisure-Time Exercise Questionnaire). Wrist-based actigraphy was worn by adolescents for 1 week to measure total sleep time (over 24 hr) and sleep efficiency percentage.ResultsThirty adolescents with narcolepsy (mean age = 13.8 ± 2.2 years, 76.7% male) participated. In this cohort of adolescents with narcolepsy, 23.3% had CDI-2 total scores in the elevated range. Greater CDI-2 total scores were associated with poor sleep quality (ρ = 0.571; p = 0.02), EDS (ρ = 0.360; p = 0.05), and lower self-reported PA levels (ρ = −0.512; p < 0.01).ConclusionsAdolescents with narcolepsy report experiencing depressive symptoms, which are associated with poor sleep quality, EDS, and low PA levels. Strategies to improve nocturnal sleep quality and symptoms of EDS as well as promoting increased PA levels in adolescents with narcolepsy may provide an opportunity to improve depressive symptoms in this population. Multidisciplinary care with mental health and sleep specialists for adolescents with narcolepsy is needed.
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"Augmentin-induced hjepato-renal failure and death Division of Gastroenterology, Allegheny General Hospital/Allegheny Campus, The Medical College of PA and Hahnemann University, Pittsburgh, PA." Hepatology 22, no. 4 (October 1995): A400. http://dx.doi.org/10.1016/0270-9139(95)95320-5.

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"HCV genotype in interferon non-responders treated for over one year . Central Blood Bank and West Penn Hospital, Pittsburgh, PA." Hepatology 22, no. 4 (October 1995): A415. http://dx.doi.org/10.1016/0270-9139(95)95383-3.

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"Microbial contamination of a hospital disinfectant dilution control system S. Jackson, MT (ASCP), CIC,* O. Harry, MS, L. Hipps, BA. Magee-Women's Hospital, Pittsburgh, PA." American Journal of Infection Control 23, no. 2 (April 1995): 129. http://dx.doi.org/10.1016/0196-6553(95)90223-6.

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"Poster 61 acute lumbosacral plexopathy caused by rhabdomyolysis: A case report. Pramila K. Kolisetty, MD (Mercy Hosp, Pittsburgh, PA); Robert Brown, DO; Sapan K. Polepalle, MD; Nader Habib Abdelmassieh, MD; Maryanne Henderson, DO; e-mail: prami2k@hotmail.com." Archives of Physical Medicine and Rehabilitation 85, no. 9 (September 2004): e21. http://dx.doi.org/10.1016/j.apmr.2004.07.122.

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25

Oh, Elizabeth, Rahul Bollam, Mownika Yadlapalli, Joel Levin, and Ricardo Arbulu. "1742. Antibiotic Use in the Podiatry Clinic: Antimicrobial Stewardship Setting Foot in Uncharted Territory." Open Forum Infectious Diseases 9, Supplement_2 (December 1, 2022). http://dx.doi.org/10.1093/ofid/ofac492.1372.

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Abstract Background Podiatrists independently manage diabetic foot ulcers (DFU), often complicated by diabetic foot infections (DFIs). The prevalence of DFU is 40 - 60% and guidelines vary in their recommendations for DFI, creating a target for antimicrobial stewardship. However, the prevalence and appropriateness of antibiotics prescribed by podiatrists has not been reported. We describe both variables among patients with DFU in a podiatry clinic. Methods We conducted a retrospective chart review of all consecutive patients &gt; 18 years of age with DFUs, infected or not, who had at least one visit to the UPMC Mercy Wound Clinic (Pittsburgh, PA) in 2020. We defined severity of infection using the PEDIS score and diagnosis of osteomyelitis (OM) (Figure 1). We collected data on antibiotics prescribed by podiatry in the clinic or by any provider during a hospitalization for DFI. Figure 2 shows our appropriateness criteria. Figure 1:Stratification of Severity of Diabetic Foot InfectionFigure 2:Criteria for Appropriateness of Antibiotic Use in Diabetic Foot Ulcers Results Of 72 patients with DFU, 32 (44.4%) received an antibiotic. Compared to those who did not receive antibiotics, patients who did were more likely male (86.2% vs. 63.6%), had a higher PEDIS score (2.03 vs. 1.49), and were more frequently diagnosed with OM (71.9% vs. 26.8%). (Table 1). Table 2 shows the most common antibiotics. Among the five patients with no to mild infection, none received appropriate treatment (Table 3). Two patients in that category received IV antibiotics (when hospitalized for DFI), and neither received an Infectious Diseases (ID) consult. The other three were considered inappropriate due to durations &gt; 7 days. The mean length of treatment for patients with mild infection was 12.6 (4.56). The two patients with moderate infection who received antibiotics had “inappropriate” courses; however, both had complicated Staphylococcus aureus bacteremia, and therefore 4-6 weeks courses were justified. All 12 inappropriate courses in severe infections were due to courses &gt; 42 days. Conclusion Prescription of antibiotics among patients with DFU was common. Our findings suggest potential targets for antimicrobial stewardship: unnecessarily long courses an IV antibiotic use in patients with mild or no infection. Our criteria can be refined to recognize situations in which prolonged therapy may be justified, and larger studies are warranted. Disclosures All Authors: No reported disclosures.
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