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Journal articles on the topic 'Meropenem'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 July 2024

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1

Fawaz, Sarah, Stephen Barton, Laura Whitney, Julian Swinden, and Shereen Nabhani-Gebara. "Stability of Meropenem After Reconstitution for Administration by Prolonged Infusion." Hospital Pharmacy 54, no. 3 (May 30, 2018): 190–96. http://dx.doi.org/10.1177/0018578718779009.

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Objective: Meropenem is a parenteral carbapenem antibiotic which has a broad spectrum of activity against aerobes and anaerobes. Meropenem’s bactericidal activity is determined by the time during which meropenem concentration remains above the minimal inhibition concentration (MIC) during the dosing interval. Thus, prolonged infusion is the optimal way to maximize the time-dependant activity. However, studies to date have shown that carbapenems and in particular, meropenem, are relatively unstable in solution. The aims of this study were therefore (1) to establish the effects of temperature on the concentration of a generic brand reconstituted meropenem solution and (2) to determine whether 24-hour continuous infusion is possible without concentrations dropping below the recommended 90%. Method: Preliminary examination was carried out by the means of nuclear magnetic resonance (NMR) spectroscopy. Meropenem was subsequently assayed using high-performance liquid chromatography (HPLC). The method was developed and validated in compliance with International Council for Harmonisation (ICH) guidelines. Meropenem’s stability was examined at two temperatures 22°C and 33°C to mimic average and high temperature in hospital wards. Solutions were prepared aseptically at the clinically relevant concentration. Results: NMR results obtained showed an increase in open ring methyl groups peak intensity, indicating that meropenem begins to degrade upon dissolution (d=1.05 and 1.25). Results obtained from quantitative HPLC confirm that meropenem concentrations dropped to 90% of initial concentration at 7.4 hours and 5.7 hours at 22°C and 33°C, respectively. Conclusion: Although results obtained indicate that meropenem should not be continuously infused over 24 hours, it is possible that meropenem could be continuously infused for at least 7 hours if temperature does not exceed 22°C and for 5 hours if temperature does not exceed 33°C.
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2

Чеботарь, И. В., Ю. А. Бочарова, А. В. Чаплин, Т. А. Савинова, Ю. А. Василиадис, and Н. А. Маянский. "Mutatsionnyye osnovy formirovaniya ustoychivosti k meropenemu u Pseudomonas aeruginosa." Вестник Российского государственного медицинского университета, no. 2022(6) (December 2022): 64–69. http://dx.doi.org/10.24075/vrgmu.2022.063.

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Rezistentnyye k karbapenemam shtammy Pseudomonas aeruginosa rastsenivayut v kachestve kriticheski opasnykh patogenov pervogo urovnya prioriteta. Rasshifrovka mekhanizmov formirovaniya ustoychivosti k karbapenemam yavlyayetsya aktual'noy zadachey sovremennoy meditsinskoy nauki. Tsel'yu raboty bylo opisat' raznoobraziye i zakrepleniye mutatsiy, assotsiirovannykh s formirovaniyem karbapenemrezistentnosti v protsesse adaptatsii P. aeruginosa k povyshayushchimsya kontsentratsiyam meropenema. Ob"yektami issledovaniya byli izolyaty P. aeruginosa, poluchennyye pri roste referentnogo shtamma P. aeruginosa ATCC 27853 v gradiyente vozrastayushchikh kontsentratsiy meropenema. Otsenku chuvstvitel'nosti izolyatov k meropenemu vypolnyali pri pomoshchi ye-testov (epsilometricheskiy metod) s meropenemom i pri pomoshchi metoda dilyutsii antibiotika v agare. Genomy izolyatov byli sekvenirovany na polnogenomnom sekvenatore MGISEQ-2000. Poluchennyye rezul'taty pokazali, chto formirovaniye vysokikh urovney rezistentnosti k meropenemu u P. aeruginosa v eksperimente proiskhodit v korotkiye sroki (6 sutok). Evolyutsiya rezistentnosti sopryazhena s protsessom klonirovaniya, pri kotorom proiskhodit vozniknoveniye mnozhestva klonov s razlichnymi genotipami. Osnovoy klonirovaniya yavlyayetsya mutagenez, v kotoryy vovlecheny 11 genov, vklyuchaya oprD, pbuE, nalD, nalC, spoT, mlaA, mexD, mexR, oprM, mraY, pbp3. Chast' obrazovavshikhsya klonov, nezavisimo ot urovnya ikh rezistentnosti k meropenemu, ne poluchayut progressivnogo razvitiya i vytesnyayutsya boleye uspeshnymi klonami.
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3

&NA;. "Meropenem." Reactions Weekly &NA;, no. 1196 (April 2008): 29. http://dx.doi.org/10.2165/00128415-200811960-00084.

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4

Wiseman, Lynda R., Antona J. Wagstaff, Rex N. Brogden, and Harriet M. Bryson. "Meropenem." Drugs 50, no. 1 (July 1995): 73–101. http://dx.doi.org/10.2165/00003495-199550010-00007.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1401 (May 2012): 24. http://dx.doi.org/10.2165/00128415-201214010-00094.

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6

&NA;. "Meropenem." Reactions Weekly &NA;, no. 1404 (June 2012): 29. http://dx.doi.org/10.2165/00128415-201214040-00097.

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7

Hurst, Miriam, and Harriet M. Lamb. "Meropenem." Drugs 59, no. 3 (March 2000): 653–80. http://dx.doi.org/10.2165/00003495-200059030-00016.

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8

Lowe, Matthew N., and Harriet M. Lamb. "Meropenem." Drugs 60, no. 3 (September 2000): 619–46. http://dx.doi.org/10.2165/00003495-200060030-00010.

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9

Baldwin, Claudine M., Katherine A. Lyseng-Williamson, and Susan J. Keam. "Meropenem." Drugs 68, no. 6 (2008): 803–38. http://dx.doi.org/10.2165/00003495-200868060-00006.

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10

&NA;. "Meropenem." Reactions Weekly &NA;, no. 871 (September 2001): 9. http://dx.doi.org/10.2165/00128415-200108710-00027.

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11

Holliday, Stephen M., and Paul Benfield. "Meropenem." PharmacoEconomics 13, no. 3 (1998): 359–77. http://dx.doi.org/10.2165/00019053-199813030-00010.

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12

&NA;. "Meropenem." Reactions Weekly &NA;, no. 1277 (November 2009): 28. http://dx.doi.org/10.2165/00128415-200912770-00081.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1254 (May 2009): 28. http://dx.doi.org/10.2165/00128415-200912540-00080.

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14

&NA;. "Meropenem." Drugs & Therapy Perspectives 6, no. 10 (November 1995): 1–5. http://dx.doi.org/10.2165/00042310-199506100-00001.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 975 (November 2003): 12. http://dx.doi.org/10.2165/00128415-200309750-00032.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 985 (January 2004): 13. http://dx.doi.org/10.2165/00128415-200409850-00042.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1301 (May 2010): 34–35. http://dx.doi.org/10.2165/00128415-201013010-00119.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1307 (June 2010): 31. http://dx.doi.org/10.2165/00128415-201013070-00100.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1308 (July 2010): 25. http://dx.doi.org/10.2165/00128415-201013080-00071.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1334 (January 2011): 31. http://dx.doi.org/10.2165/00128415-201113340-00107.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1334 (January 2011): 31. http://dx.doi.org/10.2165/00128415-201113340-00108.

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&NA;. "Meropenem." Reactions Weekly &NA;, no. 1335 (January 2011): 30. http://dx.doi.org/10.2165/00128415-201113350-00106.

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23

Bradley, John S. "MEROPENEM." Pediatric Infectious Disease Journal 17, no. 3 (March 1998): 249–50. http://dx.doi.org/10.1097/00006454-199803000-00016.

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24

Савинова, Т. А., Ю. А. Бочарова, А. В. Чаплин, Д. О. Коростин, О. В. Шамина, Н. А. Маянский, and И. В. Чеботарь. "Meropenem-inducirovannoe snizhenie chuvstvitel'nosti k kolistinu u Pseudomonas aeruginosa ATCC 27853." Вестник Российского государственного медицинского университета, no. 2022(1) (January 2022). http://dx.doi.org/10.24075/vrgmu.2022.001.

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Nechuvstvitel'nye k antibiotikam shtammy Pseudomonas aeruginosa predstavlyayut soboj global'nuyu problemu v zdravoohranenii. Issledovanie mekhanizmov vozniknoveniya rezistentnosti lezhit v osnove razrabotki sposobov bor'by s P. aeruginosa. Cel'yu raboty bylo issledovat' vozniknovenie kross-rezistentnosti u P. aeruginosa v processe adaptacii k populyarnomu antibiotiku meropenemu. Ob"ektami issledovaniya byli obrazcy P. aeruginosa, poluchennye pri roste referentnogo shtamma P. aeruginosa ATCC 27853 na srede s vozrastayushchej koncentraciej meropenema. CHuvstvitel'nost' izolyatov k karbapenemam i kolistinu opredelyali pri pomoshchi razvedeniya v agare, chuvstvitel'nost' k kolistinu ocenivali metodom serijnyh razvedenij. Bylo polucheno 93 izolyata P. aeruginosa, dva iz kotoryh imeli snizhennuyu chuvstvitel'nost' odnovremenno k karbapenemam (meropenem, imipenem) i kolistinu. Genomy izolyatov sekvenirovali na polnogenomnom sekvenatore MGISEQ-2000; obnaruzheny missens-mutacii v genah oprD i mexD i nonsens-mutaciya v phoQ. Poluchnnye rezul'taty pokazyvayut, chto pri vozdejstvii meropenema na shtammy P. aeruginosa mozhet razvivat'sya kross-rezistentnost' k kolistinu — preparatu rezerva dlya lecheniya sinegnojnoj infekcii.
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25

"Meropenem." Reactions Weekly 1839, no. 1 (January 2021): 184. http://dx.doi.org/10.1007/s40278-021-90022-x.

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26

"Meropenem." Reactions Weekly 1850, no. 1 (April 2021): 182. http://dx.doi.org/10.1007/s40278-021-93987-3.

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27

"Meropenem." Reactions Weekly 1851, no. 1 (April 2021): 217. http://dx.doi.org/10.1007/s40278-021-94307-7.

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28

"Meropenem." Reactions Weekly 1843, no. 1 (February 2021): 233. http://dx.doi.org/10.1007/s40278-021-91335-0.

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29

"Meropenem." Reactions Weekly 1844, no. 1 (February 2021): 274. http://dx.doi.org/10.1007/s40278-021-91721-6.

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30

"Meropenem." Reactions Weekly 1912, no. 1 (June 2022): 276. http://dx.doi.org/10.1007/s40278-022-17979-6.

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31

"Meropenem." Reactions Weekly 1912, no. 1 (June 2022): 275. http://dx.doi.org/10.1007/s40278-022-17978-6.

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32

"Meropenem." Reactions Weekly 1919, no. 1 (August 13, 2022): 357. http://dx.doi.org/10.1007/s40278-022-21299-6.

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33

"Meropenem." Reactions Weekly 1916, no. 1 (July 2022): 259. http://dx.doi.org/10.1007/s40278-022-19718-x.

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"Meropenem." Reactions Weekly 1917, no. 1 (July 2022): 352. http://dx.doi.org/10.1007/s40278-022-20223-3.

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35

"Meropenem." Reactions Weekly 1920, no. 1 (August 20, 2022): 296. http://dx.doi.org/10.1007/s40278-022-21833-0.

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36

"Meropenem." Reactions Weekly 1908, no. 1 (May 2022): 333. http://dx.doi.org/10.1007/s40278-022-16061-2.

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37

"Meropenem." Reactions Weekly 1903, no. 1 (April 2022): 229. http://dx.doi.org/10.1007/s40278-022-13791-7.

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38

"Meropenem." Reactions Weekly 1918, no. 1 (August 6, 2022): 298. http://dx.doi.org/10.1007/s40278-022-20755-3.

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39

"Meropenem." Reactions Weekly 1909, no. 1 (June 2022): 338. http://dx.doi.org/10.1007/s40278-022-16625-7.

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"Meropenem." Reactions Weekly 1910, no. 1 (June 2022): 281. http://dx.doi.org/10.1007/s40278-022-17116-2.

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41

"Meropenem." Reactions Weekly 1874, no. 1 (September 2021): 161. http://dx.doi.org/10.1007/s40278-021-02818-z.

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42

"Meropenem." Reactions Weekly 1861, no. 1 (June 2021): 192. http://dx.doi.org/10.1007/s40278-021-97992-3.

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43

"Meropenem." Reactions Weekly 1863, no. 1 (July 2021): 216. http://dx.doi.org/10.1007/s40278-021-98820-9.

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44

"Meropenem." Reactions Weekly 1901, no. 1 (April 2022): 302. http://dx.doi.org/10.1007/s40278-022-12979-8.

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"Meropenem." Reactions Weekly 1899, no. 1 (March 2022): 234. http://dx.doi.org/10.1007/s40278-022-12208-3.

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46

"Meropenem." Reactions Weekly 1875, no. 1 (October 2021): 202. http://dx.doi.org/10.1007/s40278-021-03118-x.

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47

"Meropenem." Reactions Weekly 1876, no. 1 (October 2021): 190. http://dx.doi.org/10.1007/s40278-021-03439-2.

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48

Escolar, M., and J. Honorato. "Meropenem." Revista de Medicina de la Universidad de Navarra, April 11, 2017, 42–47. http://dx.doi.org/10.15581/021.8865.

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49

"Meropenem." Reactions Weekly 1929, no. 1 (October 22, 2022): 390. http://dx.doi.org/10.1007/s40278-022-26014-3.

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50

"Meropenem." Reactions Weekly 1926, no. 1 (October 1, 2022): 298. http://dx.doi.org/10.1007/s40278-022-24576-6.

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