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Journal articles on the topic 'Mesenchyma Stem Cell'

Author: Grafiati

Published: 4 June 2025

Last updated: 14 July 2025

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1

Jing, Wang, Wang Zhiguo, Cai Xia, Li kun, Hao Rongan, and An Yu. "Research Progress on Exosomes Derived from Human Adipose Mesenchymal Stem Cells." International Journal of Sciences Volume 8, no. 2019-03 (2019): 114–17. https://doi.org/10.5281/zenodo.3350635.

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Mesenchymal stem cells (MSC) have the potential of multi-directional differentiation, have stable genetic information, can self-replicate and renew, and are commonly used as seed cells in the field of regeneration1. Adipose mesenchymal stem cells, bone marrow mesenchymal stem cells and umbilical cord mesenchymal stem cells are the most commonly used mesenchymal stem cells. Compared with other mesenchymal stem cells, adipose mesenchymal stem cells have a wide range of sources, relatively simple acquisition methods and less trauma2. Therefore, adipose mesenchymal stem cells have gradually become a new favorite in stem cell research. However, due to the harsh storage conditions and inconvenient transportation of living cells, the survival rate of direct transplantation into living organisms is low, which makes it difficult for clinical application. Exosome is a kind of extracellular secretory vesicle, which exists in almost all body fluids and can be extracted from the supernatant of most cultured cells in vitro3. It has the characteristics of secretory cells, simple storage, convenient transportation and low immunogenicity, providing a new direction for the clinical application of adipose mesenchymal stem cells. Therefore, this paper reviews the exosomes derived from adipose mesenchymal stem cells.Read Complete Article at ijSciences: V82019021984 AND DOI: http://dx.doi.org/10.18483/ijSci.1984

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2

Zhou, Jiankang, Kun Zhang, Shanshan Ma, et al. "Preparing an injectable hydrogel with sodium alginate and Type I collagen to create better MSCs growth microenvironment." e-Polymers 19, no. 1 (2019): 87–91. http://dx.doi.org/10.1515/epoly-2019-0011.

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AbstractIn the past few decades, stem cell transplantation has been generally accepted as an effective method on the treatment of tissue and organ injury. However, the insufficient number of transplanted stem cells and low survival rate that caused by series of negative conditions limit the therapeutic effect. In this contribution, we developed an injectable hydrogel composed of sodium alginate (SA) and Type I collagen (ColI), as the tissue scaffold to create better growth microenvironment for the stem cells. Compared the traditional SA scaffold, the ColI/SA hydrogel inherits its biomimetic properties, and simultaneously has shorter gelation time which means less loss of the transplanted stem cells. The mesenchyma stem cell (MSC) culture experiments indicated that the ColI/SA hydrogel could prevent the MSC apoptosis and contributed to faster MSC proliferation. It is highlighted that this ColI/SA hydrogel may have potential application for tissue regeneration and organ repair as the stem cell scaffold.

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3

Ahmed Elkammar, Hala. "Effect of human bone marrow derived mesenchymal stem cells on squamous cell carcinoma cell line." International Journal of Academic Research 6, no. 1 (2014): 110–16. http://dx.doi.org/10.7813/2075-4124.2014/6-1/a.14.

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PANGESTY, Azizah intan, Takaaki ARAHIRA, and Mitsugu TODO. "1F42 Characterization of Osteochondral Cell Sheets of Human Mesenchymal Stem Cell." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2015.27 (2015): 253–54. http://dx.doi.org/10.1299/jsmebio.2015.27.253.

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5

RemyaV, RemyaV, Naveen Kumar, and Kutty M. V. H. Kutty M.V.H. "A Method for Cell Culture and RNA Extraction of Rabbit Bone Marrow Derived Mesenchymal Stem Cells." International Journal of Scientific Research 3, no. 7 (2012): 31–33. http://dx.doi.org/10.15373/22778179/july2014/11.

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6

Gupta, PD. "Menstrual Blood Mesenchymal Stem Cells: Boon in Therapeutics." Biotechnology and Bioprocessing 2, no. 4 (2021): 01–06. http://dx.doi.org/10.31579/2766-2314/032.

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Stem cell therapy gained momentum for the past three decades in therapeutics. Alternative strategies are indispensable for the treatment of many diseases in the present scenario due to side effects of synthetic chemicals as drugs. Mesenchymal cells of different origin have been in use with good results, though ethical issues and limited availability is a drawback. Novel menstrual blood mesenchymal stems cells prove to be a wealth out of waste is a boon in therapeutics. In this review we bring a bird’s eye view of different diseases treated with menstrual blood mesenchymal stem cells with positive results. Evolution in the use of these cells more and more will be a big relief to many who suffer with side effects of drugs.

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Izawa, H., K. Shirakawa, N. Sotozaki, and T. Matsuoka. "Examination of the method that is most suitable for the influence on sleep in the transplant of the mesenchyma system stem cell and cognitive function and QOL evaluation." Sleep Medicine 40 (December 2017): e144. http://dx.doi.org/10.1016/j.sleep.2017.11.421.

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8

Adel, Ghadeer M., Ahmed A. Khalil, and Ahmed A. Moustafa. "Stem Cell with a Peri-implant Defects." NeuroQuantology 20, no. 4 (2022): 466–68. http://dx.doi.org/10.14704/nq.2022.20.4.nq22288.

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Periodontal regeneration aims are restoring of the destructed bone, cementum and periodontal ligament. The new strategies of regeneration is very challenging, one of these strategies is tissue engineering, including stem cells and it's considered very promising solution. This paper aims to review the use of stem cells for the treatment of peri-implant defects. Nowadays, many types of mesenchymal stem cells (MSCs) have the ability of periodontal regeneration in animal studies. The bone marrow MSCs (BMMSCs), dental pulp stem cell (DPSC), periodontal ligament stem cells (PDLSCs), and gingival mesenchymal stem cells (GMSCs) are the most types that give very promising results in animal models.

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9

Zahran, Faten, Ahmed Abdel Zaher Ahmed Abdel.Zaher, Nermin Raafat, and Mohamed Ali Mohamed Ali. "Hepatocyte derived from Rat Bone Marrow Mesenchymal Stem Cells." Indian Journal of Applied Research 3, no. 10 (2011): 1–5. http://dx.doi.org/10.15373/2249555x/oct2013/135.

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10

Zahran F, Zahran F., El-Ghareb M. El-Ghareb M, Hamed S. Hamed S, and Nabil A. Nabil A. "Evaluation of Renal Tubulointerstitial Injury after Mesenchymal Stem Cells Treatment." Indian Journal of Applied Research 4, no. 4 (2011): 17–24. http://dx.doi.org/10.15373/2249555x/apr2014/4.

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11

Maluyk, M. O., M. A. Kulida, A. S. Serdyukov, and A. V. Bogoslavets. "Effect of mesenchymal stem cells in reparative osteogenesis in animals." Bìoresursi ì prirodokoristuvannâ 9, no. 1-2 (2016): 77–82. http://dx.doi.org/10.31548/bio2017.01.010.

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Zhong, Li, Jennifer Ly, and Qi Chu. "Novel Therapeutic Trends in Pneumonia: Antibiotics and Mesenchymal Stem Cells." Biomedical Research and Clinical Reviews 4, no. 5 (2021): 01–10. http://dx.doi.org/10.31579/2692-9406/082.

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Pneumonia remains a major cause of morbidity and mortality. With the significant global health burden that pneumonia poses, it is essential to improve therapeutic and management strategies. The increasing emergence of antibiotic-resistant bacterial strains limits options for effective antibiotic use. New antibiotics for the treatment of pneumonia may address deficits in current antimicrobial drugs, with an ability to cover both typical, atypical, and resistant pathogens. Several of these newer drugs also have structural characteristics that allow for a decreased propensity for the development of bacterial resistance. The potential use of stem cell therapies in place of corticosteroid treatments may also offer an improvement in patient outcomes. Human mesenchymal stem cell treatments have shown efficacy and safety in treating COVID-19 induced pneumonia. Combined treatment with both stem cells and antibiotics in pneumonia in a rabbit model has also shown significantly increased efficacy in comparison to antibiotic treatment alone. This presents yet another possible route for a novel strategy in treating pneumonia, though additional future studies are necessary before clinical implementation. While pneumonia remains a major disease of concern, having newer approved antibiotics as well as novel therapies such as stem cell treatments in the pipeline offers clinicians more options in effectively treating pneumonia.

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Kim, Sung-Kon, Nam-Kuk Kim, Du-Hak Yoon, Tae-Hun Kim, Boo-Keun Yang, and Hyun-Jeong Lee. "Gene Expression of Candidate Genes Involved in Fat Metabolism During In vitro Adipogenic Differentiation of Bovine Mesenchymal Stem Cell." Journal of Animal Science and Technology 52, no. 4 (2010): 265–70. http://dx.doi.org/10.5187/jast.2010.52.4.265.

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14

Ahmad, Dr Ausaf. "MESENCHYMAL STEM CELLS: A POSSIBLE SOURCE OF MULTIPLE SCLEROSIS TREATMENT." Era's Journal of Medical Research 11, no. 1 (2024): 51–55. http://dx.doi.org/10.24041/ejmr2024.8.

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There are high hopes for stem cell therapies for tissue repair because there are currently no treatments that promote the remyelination and regeneration of the neuronal network that has been damaged by the autoimmune onslaught that is present in multiple sclerosis (MS). Because of their alleged aptitude to transdifferentiate into brain cells and their power to modulate immunological responses, It has been proposed that mesenchymal stem cells (MSCs) could be used to treat MS. In the present review we highlighted the possible use of MSCs in MS patients as an alternate novel option. The small number of MS patients in research and the lack of positive benefits of MSC transplantation in cells treatments have been examined. Furthermore, the primary challenges and hazards associated with MSC therapy for MS patients have been elucidated. In conclusion, the MS treatment with MSC-based stem cell therapy showed lot of promise. However, a multitude of issues and restrictions that need to be fixed. Further research and quantification are required regarding the precise the cell stage to be transplanted, the precise description of the cell type to be given, the transplanted cells' in vivo destiny in different inflammatory models, the dosage, the mode of administration, the length of the therapeutic effect, and the stem cells' genomic stability.

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Kidoaki, Satoru, Kouske Hamano, and Thasaneeya Kuboki. "GS1-3 TRACTION FORCE MICROSCOPY OF MESENCHYMAL STEM CELLS IN MODE OF FRUSTRATED DIFFERENTIATION(GS1: Cell and Tissue Biomechanics I)." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2015.8 (2015): 118. http://dx.doi.org/10.1299/jsmeapbio.2015.8.118.

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16

Yokohama-Tamaki, Tamaki, Naoki Fujiwara, Shunichi Shibata, Satoshi Wakisaka, and Hidemitsu Harada. "The Epithelial-Mesenchymal Interaction Plays a Role in the Maintenance of the Stem Cell Niche of Mouse Incisors via Fgf10 and Fgf9 Signaling." Open Biotechnology Journal 2, no. 1 (2008): 111–15. http://dx.doi.org/10.2174/1874070700802010111.

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The continuous eruption of mouse incisors throughout life is maintained by adult stem cells in the apical end. In these teeth, the continuous expression of Fgf10 in the mesenchyme plays a role in the maintenance of the epithelial stem cell compartment, referred to as the "apical bud." However, little is known about the epithelial signaling that induces and maintains Fgf10 expression. Focusing on the epithelial-mesenchymal interaction during tooth development, we thoroughly investigated candidates expressed in the apical bud. In situ hybridization and immunostaining showed that Fgf9 mRNA and protein were detected in the basal epithelium, stellate reticulum, and inner enamel epithelium of the apical bud. Recombinant Fgf9 protein stimulated cell proliferation in cultures of apical end mesenchyme. Furthermore, Fgf9- releasing beads inhibited apoptosis in mesenchymal tissue cultures and maintained the expression of Fgf10. On the other hand, Fgf10-releasing beads induced Fgf9 expression in cultures of apical buds. Taken together, these results suggest that the stem cell niche in growing incisors is maintained by an epithelial mesenchymal interaction via Fgf9 and Fgf10 signaling.

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17

Zahran F, Zahran F., El-Deen IM El-Deen IM, Hamed S. Hamed S, and EL-Shenawy A. EL-Shenawy A. "Characterization of Adipogenic Differentiation of Mesenchymal Stem Cell Derived from Mice Adipose Tissue." Indian Journal of Applied Research 3, no. 7 (2011): 18–22. http://dx.doi.org/10.15373/2249555x/july2013/7.

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18

Zahran F, Zahran F., El-Deen IM El-Deen IM, Hamed S. Hamed S, and EL-shenawy A. EL-shenawy A. "Characterization of Adipogenic Differentiation of Mesenchymal Stem Cell Derived from Mice Bone Marrow." International Journal of Scientific Research 2, no. 6 (2012): 17–20. http://dx.doi.org/10.15373/22778179/june2013/6.

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19

Oliver, Juan A., Jonathan Barasch, Jun Yang, Doris Herzlinger, and Qais Al-Awqati. "Metanephric mesenchyme contains embryonic renal stem cells." American Journal of Physiology-Renal Physiology 283, no. 4 (2002): F799—F809. http://dx.doi.org/10.1152/ajprenal.00375.2001.

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Renal epithelial cells derive from either cells of the metanephric mesenchyme or ureteric bud cells, but the origin of other renal cells is unclear. To test whether metanephric mesenchymal cells generate cells other than epithelial, we examined the developmental potential of a metanephric mesenchymal cell line (7.1.1 cells) and of primary cultures of metanephric mesenchymal cells. 7.1.1 Cells express both mesenchymal and epithelial markers and, on confluence, form well-defined monolayers expressing epithelial junctional proteins. However, 7.1.1 cells as well as primary cultures of metanephric mesenchymal cells also generate spindle-shaped cells that are positive for α-smooth muscle actin, indicating that they are myofibroblasts and/or smooth muscle; this differentiation pathway is inhibited by collagen IV and enhanced by fetal calf serum or transforming growth factor-β1. Transforming growth factor-β1also induces expression of smooth muscle proteins, indicating that the cells differentiate into smooth muscle. 7.1.1 Cells as well as primary cultures of metanephric mesenchymal cells also express vascular endothelial growth factor receptor 2 and Tie-2, suggesting that the metanephric mesenchymal cells that generate epithelia may also differentiate into endothelial cells. The pluripotency of the 7.1.1 cells is self-renewing. The data suggest that the metanephric mesenchyme contains embryonic renal stem cells.

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20

Abadie, M. S. Al, N. Abed, and M. Mahfoudh. "Stem Cell therapy for Hair Loss." Medical & Clinical Research 10, no. 03 (2025): 01–04. https://doi.org/10.33140/mcr.10.03.06.

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Stem cell research has made significant strides since its inception, with applications expanding into regenerative medicine and therapeutic treatments for various conditions, including hair loss. The discovery of hematopoietic stem cells (HSCs) in the 1960s and the advent of induced pluripotent stem cells (iPSCs) in 2006 have propelled the field into new frontiers. Stem cell-based therapies for hair loss focus on regenerating hair follicles, with sources ranging from adipose-derived stem cells (ADSCs) to hair follicle mesenchymal stem cells. These approaches leverage the unique properties of stem cells, including self-renewal and differentiation, to address androgenetic alopecia and other conditions. Stem cells promote hair growth by activating dermal papilla cells, stimulating follicular regeneration, and enhancing hair density. Techniques such as intradermal injections combined with growth factors and vitamins further optimize therapeutic outcomes. This review highlights the mechanisms, sources, and applications of stem cells in hair loss treatment, emphasizing their potential to revolutionize hair restoration therapies.

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21

Herzlinger, D., C. Koseki, T. Mikawa, and Q. al-Awqati. "Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction." Development 114, no. 3 (1992): 565–72. http://dx.doi.org/10.1242/dev.114.3.565.

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At least fourteen epithelial cell types of the mammalian nephron develop from the metanephric mesenchyme. To distinguish whether this single embryological primordium contains a heterogenous population of committed renal cell lines or a multipotent stem cell, the lac-Z gene was introduced into individual renal progenitors by retroviral mediated gene transfer. The differentiated fate of lac-Z-tagged daughters derived from single metanephric mesenchymal cells was characterized after cytodifferentiation. We found that the metanephric mesenchyme contains multipotent stem cells that can generate at least three distinct cell types; glomerular, proximal and distal epithelia. After induction the fate of this multipotent cell becomes restricted to populate a single nephron segment.

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22

Sekenova, A., and V. Ogay. "Role of mesenchymal stem cells in the regulation of immune response." BULLETIN of the L.N. Gumilyov Eurasian National University. BIOSCIENCE Series 123, no. 2 (2018): 69–83. http://dx.doi.org/10.32523/2616-7034-2018-123-2-69-83.

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23

Zahran F, Zahran F., El-Ghareb M. El-Ghareb M, Nashwa Barakat, and El-Naggar I. El-Naggar I. "Biochemical Evaluation to Mesenchymal Stem Cells Therapy of Renal Tubulointerstitial Injury." Indian Journal of Applied Research 3, no. 10 (2011): 1–5. http://dx.doi.org/10.15373/2249555x/oct2013/6.

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Elgaly, Maher E., Mohamed E. El Ghareeb, and Farha El shennawy. "Cord Blood Mesenchymal Stem Cells Conditioned Media Suppress Epithelial Ovarian Cancer Cells in Vitro." International Journal of Trend in Scientific Research and Development Volume-2, Issue-5 (2018): 1783–88. http://dx.doi.org/10.31142/ijtsrd18182.

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25

Gallon, Alex. "Auto Fluorescent Cells, Including Mesenchymal Stem Cells, are Indeed Amenable to Flow Cytometric Analyses." Stem Cells Research and Therapeutics International 1, no. 1 (2019): 01. http://dx.doi.org/10.31579/2643-1912/001.

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Zhang, Jun, Chuan Lei, Yanfei Deng, Jam zaheer Ahmed, Deshun Shi, and Fenghua Lu. "Hypoxia Enhances Mesenchymal Characteristics Maintenance of Buffalo Bone Marrow-Derived Mesenchymal Stem Cells." Cellular Reprogramming 22, no. 3 (2020): 167–77. http://dx.doi.org/10.1089/cell.2019.0097.

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27

Zahran F, Zahran F., El-Ghareb M. El-Ghareb M, and Nabil A. Nabil A. "Bone Marrow Derived Mesenchymal Stem Cells As A Therapy for Renal Injury." Indian Journal of Applied Research 4, no. 4 (2011): 11–16. http://dx.doi.org/10.15373/2249555x/apr2014/3.

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He, Junxian. "#260 : Spatial Analysis of Adenomyosis Reveals the Inflammatory Feature of Immune Cells and Provide Insights into the Ciliated Cell in Ectopic Endometrium." Fertility & Reproduction 05, no. 04 (2023): 503–4. http://dx.doi.org/10.1142/s2661318223742704.

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Adenomyosis is a prevalent and non-cancerous uterine disease which can significantly impaired the fertility of reproductive-age women. However, the etiology, as well as the cellular and molecular mechanism underlying adenomyosis remain largely unknown. Here, we utilized cutting-edge spatial and single-cell RNA sequencing technologies to create a comprehensive transcriptional atlas of adenomyosis pathology. Our spatial profiling clearly distinguished gland, mesenchyma and myometrium regions, recapitulating spatial transcriptome structural characteristics of uterus. Moreover, we analyzed the expression profiles of 69,115 single cells and integrated them with spatial data. The analysis of immune cells showed a distinct immune inflammatory microenvironment in the eutopic and ectopic endometrial glands of adenomyosis. Notably, we discovered an increased number of DNAH9+ ciliated cells in ectopic endometrial glands, indicating their potential role in the formation of ectopic endometrium. These findings provide cellular evidence to support the invagination theory and offer a new vision on the pathophysiology and clinical intervention of adenomyosis. Background and Aims: Adenomyosis is characterized by the presence of endometrial glands and stroma-like tissue within the myometrium 1 , resulting in abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain and infertility 2 . Around 35% of reproductive-age women suffer from adenomyosis worldwide 3 , 4 . Highly variable symptoms make diagnosis challenging and commonly result in misdiagnosis. Furthermore, due to the advance of diagnostic imaging techniques such as transvaginal ultrasound scan (TVUS) and magnetic resonance imaging (MRI), there is an increasing trend of incidence rate, especially the remarkably increased proportion of young women diagnosed 4 . Although several hypotheses have been proposed to explain the pathogenesis of adenomyosis, including invagination of the endometrium into the myometrium, trauma to the endometrial-myometrial interface, and the stem cell potential of de novo ectopic tissue5, none of the these theories can fully account for all the phenotypes 6 . This ambiguous understanding of underlying pathophysiologic mechanisms hinders the development of effective early intervention strategies, emphasizing the need for further research into the biological mechanisms involved. Common symptoms of adenomyosis, such as dysmenorrhea and irregular uterine bleeding, suggest dysfunction of the endometrium, despite the absence of significant morphological change between in situ endometrium (eutopic) and the ectopic endometrial gland found within adenomyoma. Recently studies utilizing single-cell RNA sequencing (scRNA-seq) have reported functional differences within limited partial regions, offering some insight into cellular heterogeneity 7 , 8 . It is important to note that these studies have been limited in scope, either focusing on a small number of patients or lacking investigation into the spatial distribution of specific disease regions. As a result, our understanding of adenomyosis at a high-resolution level remains incomplete. Advancements in scRNA-seq and spatial transcriptomics techniques provide powerful tools to investigate rare subpopulations, cellular interactions and tissue architecture 9 , 10 , 11 , 12 . These cutting-edge technologies have the potential to enhance our understanding of adenomyosis. Method: Herein, we simultaneously combined scRNA-seq and spatial transcriptome (Geo-seq) 13 data to gain a global understanding of cell types and niches in the entire layer of adenomyosis uterus tissue. By allocating cell types to different adenomyosis niches, determining molecular mediators of intercellular interactions, and pinpointing the cellular and spatial sources of niche factors, our data shed new light on the invagination of eutopic endometrium and tissue architecture of adenomyosis. This multi-dimensional molecular profiling provides a foundation for further exploration of adenomyosis pathophysiology, enabling a better understanding of the cellular and molecular mechanisms involved. Ultimately, this study has the potential to facilitate early clinical diagnosis and medication intervention for adenomyosis. Results: Our spatial profiling clearly distinguished gland, mesenchyma and myometrium regions, recapitulating spatial transcriptome structural characteristics of uterus. Moreover, we analyzed the expression profiles of 69,115 single cells and integrated them with spatial data. The analysis of immune cells showed a distinct immune inflammatory microenvironment in the eutopic and ectopic endometrial glands of adenomyosis. Notably, we discovered an increased number of DNAH9+ ciliated cells in ectopic endometrial glands, indicating their potential role in the formation of ectopic endometrium. Conclusion: These findings provide cellular evidence to support the invagination theory and offer a new vision on the pathophysiology and clinical intervention of adenomyosis.

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Okumura, Kenji, Masanori Shinohara, and Fumio Endo. "Capability of Tissue Stem Cells to Organize into Salivary Rudiments." Stem Cells International 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/502136.

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Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM, however, an extracellular matrix gel with exogenous EGF can be used as a substitute for the mesenchyme during BrM in the developing salivary epithelium. Stem/progenitor cells isolated from salivary glands in humans and rodents can be classified as mesenchymal stem cell-like, bone-marrow-derived, duct cell-like, and embryonic epithelium-like cells. Salivary-gland-derived progenitor (SGP) cells isolated from duct-ligated rats, mice, and swine submandibular glands share similar characteristics, including intracellular laminin andα6β1-integrin expression, similar to the embryonic salivary epithelia during the pseudoglandular stage. Progenitor cells also isolated from human salivary glands (human SGP cells) having the same characteristics differentiate into hepatocyte-like cells when transplanted into the liver. Similar to the dissociated embryonic salivary epithelium, human SGP cells aggregate to self-organize into branching organ-like structures on Matrigel plus exogenous EGF. These results suggest the possibility that tissue stem cells organize rudiment-like structures, and the embryonic cells that organize into whole tissues during development are preserved even in adult tissues.

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Yuhyi Hernanda, Pratika. "ANALISIS EKSPRESI PROTEIN TLR-9, CD90 DAN VEGF PADA MESENCHYMAL STEM CELL DI JARINGAN TUMOR OSTEOSARKOMA." Jurnal Ilmiah Kedokteran Wijaya Kusuma 8, no. 2 (2019): 108–17. http://dx.doi.org/10.30742/jikw.v8i2.625.

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For further investigation on the effect of Mesenchymal Stem Cell (MSC) on tumor / cancer growth, it is necessary to start with tumor MSC profile from tumor / cancer tissue. In this study, we use MSC from osteosarcoma tissue as a representative. The MSC profile analysis method used were the comparing the phenotype and characteristics of MSC fromosteosarcoma tissue with MSC from normal adiposa tissue. The characteristics of MSC were represented by protein expression of several candidate genes namely TLR-9, CD-90 and VEGF. From the results of immunofluorescence staining on adiposa MSC compared withosteosarcoma MSC, it has obviously seen that although the phenotypes were similar, there was no significant difference in CD-90 expression in osteosarcoma MSC and adiposa MSC. Although VEGF expression appears to be slightly prominent in osteosarcoma MSCs, the difference between the two was also not significant. Whereas TLR9 expression is very prominent in osteosarcoma MSC and significantly different from adiposa MSC. Thus TLR9 may be of concern in subsequent studies to investigate the mechanism of MSC triggers tumor growth.

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An, JH, KB Kim, SC Kwon, et al. "Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome." Veterinární Medicína 67, No. 4 (2022): 206–11. http://dx.doi.org/10.17221/213/2020-vetmed.

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Renal Fanconi syndrome (RFS) affects the proximal tubular resorption in the nephrons. This causes excessive loss of key solutes through the urine. In a canine patient, we successfully managed the renal tubular acidosis and proteinuria caused by RFS via transplantation of canine adipose tissue-derived mesenchymal stem cells (cAT-MSCs). cAT-MSCs were administered ten times at intervals of 2–4 weeks. The post-therapy check-up revealed that the cAT-MSC treatment improved the renal tubular acidosis and proteinuria. Hence, a cAT-MSC transplant may be considered as an adjuvant therapy in veterinary medicine to initiate and maintain relief of RFS-induced acidosis and proteinuria.

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Song, Guanbin, Bingyu Zhang, Qing Luo, Xiang Wang, and Yang Ju. "GS1-9 Cycle mechanical stretching promotes migration and inhibits invasion of bone marrow-derived mesenchymal stem cells(GS1: Cell and Tissue Biomechanics II)." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2015.8 (2015): 123. http://dx.doi.org/10.1299/jsmeapbio.2015.8.123.

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33

Akgün, Işık. "Mesenchymal stem cell." Istanbul Bilim University Florence Nightingale Transplantation Journal 1, no. 1 (2016): 29–32. http://dx.doi.org/10.5606/fng.transplantasyon.2016.005.

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Mammadova, V., S. Ismayilova, A. Mirzayeva, X. Pashayeva, K. Alazova, and P. Mammadov. "THE ROLE OF MESENCHYMAL STEM CELL USE IN THE PREVENTION OF VIRAL INFECTIOUS DISEASES." Sciences of Europe, no. 151 (October 27, 2024): 4–6. https://doi.org/10.5281/zenodo.13998935.

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Stem cells are unspecialized cells of the human body. Stem cells can differentiate into any cell in the body and have the ability to self-renew. According to their origin, stem cells are divided into two main types: Embryonic and Adult. Stem cells are also classified as Multipotent, Totipotent, Pluripotent and Unipotent based on their range of differentiation potential. Multipotent stem cells have the ability to differentiate into all cell types within a given lineage. Stem cell therapy is used to treat several types of diseases, and stem cells have the potential to create new tissues and organs. Mesenchymal stem cells (MSCs) show potential in treating viral diseases due to their anti-inflammatory and regenerative properties, as demonstrated in conditions like COVID-19, viral pneumonia, HIV, and hepatitis B.

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Franco, GG, BW Minto, LP Coelho, et al. "Autologous adipose-derived mesenchymal stem cells and hydroxyapatite for bone defect in rabbits." Veterinární Medicína 67, No. 1 (2021): 38–45. http://dx.doi.org/10.17221/85/2020-vetmed.

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This study aims to evaluate the effect of autologous adipose-derived mesenchymal stem cells (AAD-MSC), with and without synthetic absorbable hydroxyapatite (HAP-91), on the bone regeneration in rabbits. Thirty-four female white New Zealand rabbits were submitted to a 10 mm distal diaphyseal radius ostectomy, divided into 3 experimental groups according to the treatment established. The bone gap was filled with 0.15 ml of a 0.9% saline solution containing two million AAD-MSC (G1), or AAD-MSC associated with HAP-91 (G2). The control group (CG) received only 0.15 ml of the 0.9% saline solution. Radiographs were made post-operatively, and after 15, 30, 45 and 90 days. Fifty percent of the samples were submitted to a histological examination at 45 days and the remaining ones at 90 days post-operatively. Radiographically, the periosteal reaction, bone callus volume and bone bridge quality were superior in G2 (P &lt; 0.05). Histologically, the bone repair was faster and more efficient in G1 at 45 days (P &lt; 0.05). In conclusion, AAD-MSC improved the regeneration on the experimentally induced bone defects in rabbits; however, the use of hydroxyapatite requires caution given the granulomatous reaction produced in the species.

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Moghadasali, Reza. "Therapeutic Implication of Human Bone Marrow Mesenchymal Stem Cell-Conditioned Medium to Reduce Cystogenic Potential of CD133+ Renal Progenitor Cells of Human Polycystic Kidneys." Journal of Embryology & Stem Cell Research 4, no. 1 (2020): 1–10. http://dx.doi.org/10.23880/jes-16000135.

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Osorio, Karen M., Karin C. Lilja, and Tudorita Tumbar. "Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments." Journal of Cell Biology 193, no. 1 (2011): 235–50. http://dx.doi.org/10.1083/jcb.201006068.

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Runx1 controls hematopoietic stem cell emergence and hair follicle stem cell (HFSC) activation and proliferation in adult skin. Here we use lineage tracing and mouse genetic manipulation to address the role of Runx1 in the embryonic development of HFSCs. We find Runx1 is expressed in distinct classes of embryonic skin precursors for short-term HF progenitors, adult HFSCs, and mesenchymal progenitors. Runx1 acts in the embryonic epithelium for timely emergence of adult HFSCs and short-term progenitors, but is dispensable for both of them. In contrast, Runx1 is strictly needed in the embryonic mesenchyme for proper adult HFSC differentiation and long-term skin integrity. Our data implicate Runx1 in epithelial cell adhesion and migration and in regulation of paracrine epithelial–mesenchymal cross talk. The latter involves Lef1 and Wnt signaling modulation in opposing directions from two distinct skin compartments. Thus, a master regulator of hematopoiesis also controls HFSC emergence and maintenance via modulation of bidirectional cross talking between nascent stem cells and their niche.

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Alió del Barrio, Jorge L., Ana De la Mata, María P. De Miguel, et al. "Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells." Cells 11, no. 16 (2022): 2549. http://dx.doi.org/10.3390/cells11162549.

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Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important advantage of being easily obtained (in an autologous manner) from low invasive procedures, rendering a high number of multipotent stem cells with the potential to differentiate into several cellular lineages, to show immunomodulatory properties, and to promote tissue regeneration by a paracrine action through the secretion of extracellular vesicles containing trophic factors. This secretome is currently being investigated as a potential source for a cell-free based regenerative therapy for human tissues, which would significantly reduce the involved costs, risks and law regulations, allowing for a broader application in real clinical practice. In the current article, we will review the existing preclinical and human clinical evidence regarding the use of such adipose-derived mesenchymal stem cells for the regeneration of the three main layers of the human cornea: the epithelium (derived from the surface ectoderm), the stroma (derived from the neural crest mesenchyme), and the endothelium (derived from the neural crest cells).

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Widyaputri, Tiara, Erni Sulistiawati, Dondin Sajuthi, Anita Esfandiari, and Setyo Widi Nugroho. "Studi Histologi Tubulus Ginjal Tikus Model Hipertensi yang Diterapi Menggunakan Bone Marrow Mesenchymal Stem Cell." Jurnal Veteriner 22, no. 3 (2021): 422–28. http://dx.doi.org/10.19087/jveteriner.2021.22.3.422.

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Akhir-akhir ini banyak peneliti yang mempelajari terapi berbasis sel sebagai terapi regeneratif untuk melindungi atau memperbaiki jaringan yang rusak. Bone marrow mesenchymal stem cell (BMMSC) memiliki kemampuan yang menjanjikan dalam memperbaiki ginjal. Tujuan penelitian ini adalah untuk mengetahui apakah induksi yang dilakukan dapat menyebabkan kerusakan tubulus ginjal dan BMMSC mampu melindungi atau memperbaiki kerusakan yang terjadi. Penelitian ini menggunakan dua belas tikus jantan umur 10-12 minggu dengan rata-rata tekanan darah sistolik minimum mencapai 140-150 mmHg yang dibagi menjadi kelompok kontrol dan kelompok terapi. Tekanan darah yang tinggi diinduksi dengan mengangkat ginjal kanan, mengikat arteri karotis komunis kiri, serta memberikan NaCl 1%, DOCA 2,5 mg/100gBB, dan BAPN 0,12%. Bone marrow mesenchymal stem cell disuntikkan setelah 16 minggu induksi. Evaluasi histopatologi ginjal yang didukung dengan evaluasi darah dilakukan dua minggu setelah injeksi BMMSC. Berdasarkan evaluasi histopatologi, kerusakan tubulus ginjal pada dua kelompok tidak menunjukkan hasil yang berbeda. Demikian juga regenerasi pada kedua kelompok menunjukkan hasil sama. Kadar blood urea nitrogen (BUN) dan kreatinin pada kedua kelompok berada dalam kisaran kadar normal. Hasil yang didapat menunjukkan bahwa kerusakan yang terjadi tidak parah dan BMMSC memperbaiki tubulus ginjal akan tetapi belum dapat melindungi tubulus ginjal dari kerusakan.

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Li, Huiyun, Muzhe Li, Xun Ran, et al. "The Role of Zinc in Bone Mesenchymal Stem Cell Differentiation." Cellular Reprogramming 24, no. 2 (2022): 80–94. http://dx.doi.org/10.1089/cell.2021.0137.

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Wang, Jian, Xuanxuan Guo, Zhanrong Kang, et al. "Roles of Exosomes from Mesenchymal Stem Cells in Treating Osteoarthritis." Cellular Reprogramming 22, no. 3 (2020): 107–17. http://dx.doi.org/10.1089/cell.2019.0098.

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Morita, Yasuyuki, Toshihiro Sato, and Yang Ju. "OS18-8 Rigorous Optimal Cyclic Strain for Differentiation of Mesenchymal Stem Cells into Tenocytes using an Exhaustive Strain Field(Cell and Tissue mechanics 3,OS18 Cell and tissue mechanics,BIOMECHANICS)." Abstracts of ATEM : International Conference on Advanced Technology in Experimental Mechanics : Asian Conference on Experimental Mechanics 2015.14 (2015): 242. http://dx.doi.org/10.1299/jsmeatem.2015.14.242.

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Karagiannidou, Angeliki, Ioanna Varela, Krinio Giannikou, et al. "Mesenchymal Derivatives of Genetically Unstable Human Embryonic Stem Cells Are Maintained Unstable but Undergo Senescence in Culture As Do Bone Marrow–Derived Mesenchymal Stem Cells." Cellular Reprogramming 16, no. 1 (2014): 1–8. http://dx.doi.org/10.1089/cell.2013.0040.

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Nandakishore, Ghoshal, Pradhan Arnab, Das Samiran, Bhattacharyya Jayanta, Ghosh Soumitra, and Niyogi Soumadip. "Stem cell-based regenerative prosthodontics: A new era in prosthodontics." Journal of Orofacial Rehabilitation 2, no. 1 (2022): 29–40. https://doi.org/10.5281/zenodo.6437646.

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<strong>Abstract</strong> The ultimate goal for tissue engineering and regenerative medicine is to develop therapies to rejuvenate lost or damaged tissue using engineered or regenerated products derived from either donor or autologous cells. Cell-based therapies are widely used in the field of regenerative medicine. Stem cells are undifferentiated or partially differentiated biological cells found in multicellular organisms that can differentiate into specialized cells. Two types of stem cells are present in humans. These are the embryonic and the adult stem cells. Embryonic stem cells are isolated from inner cell mass blastocytes, and adult stem cells are found in various tissues. The dental pulp stem cells are the pluripotent mesenchymal stem cells (MSC), which are the most commonly used. However, bone marrow-derived mesenchymal stem cells are another commonly used cell type in stem cell-based regenerative prosthodontics. They help to rebuild the bone structure of the defects of craniofacial region, particularly the maxilla and mandible. Stem cell therapy is the new horizon in the field of regenerative dentistry.

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Li, Bo, Yigan Wang, Yi Fan, Takehito Ouchi, Zhihe Zhao, and Longjiang Li. "Cranial Suture Mesenchymal Stem Cells: Insights and Advances." Biomolecules 11, no. 8 (2021): 1129. http://dx.doi.org/10.3390/biom11081129.

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The cranial bones constitute the protective structures of the skull, which surround and protect the brain. Due to the limited repair capacity, the reconstruction and regeneration of skull defects are considered as an unmet clinical need and challenge. Previously, it has been proposed that the periosteum and dura mater provide reparative progenitors for cranial bones homeostasis and injury repair. In addition, it has also been speculated that the cranial mesenchymal stem cells reside in the perivascular niche of the diploe, namely, the soft spongy cancellous bone between the interior and exterior layers of cortical bone of the skull, which resembles the skeletal stem cells’ distribution pattern of the long bone within the bone marrow. Not until recent years have several studies unraveled and validated that the major mesenchymal stem cell population of the cranial region is primarily located within the suture mesenchyme of the skull, and hence, they are termed suture mesenchymal stem cells (SuSCs). Here, we summarized the characteristics of SuSCs, this newly discovered stem cell population of cranial bones, including the temporospatial distribution pattern, self-renewal, and multipotent properties, contribution to injury repair, as well as the signaling pathways and molecular mechanisms associated with the regulation of SuSCs.

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Zhang, Jun, Xiling Qin, Yanfei Deng та ін. "Transforming Growth Factor-β1 Enhances Mesenchymal Characteristics of Buffalo (Bubalus bubalis) Bone Marrow-Derived Mesenchymal Stem Cells". Cellular Reprogramming 23, № 2 (2021): 127–38. http://dx.doi.org/10.1089/cell.2020.0093.

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Tarigan, Elpita, Adisti Dwijayanti, Frans Dhyanagiri Suyatna, et al. "PROLONGED LIFESPAN OF AGING RAT AFTER XENOTRANPLANTATION OF HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS (hUC-MSCs)." Jurnal Veteriner 21, no. 4 (2020): 539–49. http://dx.doi.org/10.19087/jveteriner.2020.21.4.539.

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Currently, mesenchymal stem cells (MSCs) for implementing regenerative medicine in aging become interest in medical research science, especially in degerative disease and other aging problems. This research was aimed to determine the effectiveness of hUC-MSCs on inhibiting the aging process through the lifetime of the rat and the effect of intravenous administration of hUC-MSCs in phisiologycally aging female rat on the blood analysis. This study was used 40 aged female rats with 29-30 months of age divided into four groups with 10 rats each. The control rat group was given physiological NaCl (0.9%) 0.5 mL, and the treated rat group was given hUC-MSCs 1x107 cells/kg body weight in 0.5 mL NaCl 0.9%, was injected intravenously in caudo lateralis tail vein with stratified frequency; one time injection (SC1), three times injections (SC3) and five times injections (SC5). Perifer blood was collected from retro-ortbital sinus vein 30 days before and after injection of hUC-MSCs for hematology and blood chemistry analysis. Based on the results were obtained, it indicated that hUC-MSCs increased the survival of aging rat were in treatment group, life span of rats was extended up to 40 months compared to the average life of control rat aged up to 34±2 months. The injection of hUC-MSCs 1x107 cells/kg of body weight with one, three and five times injection were affected to blood profiles and blood chemistry with correlation were low. The conclusions are hUC-MSCs extend the lifespan of aging rat and were affect the blood in general but in normal range of aging rat, affect in ALT and creatinin as tissue repair and tolerated by aging rat.

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Trohatou, Ourania, and Maria G. Roubelakis. "Mesenchymal Stem/Stromal Cells in Regenerative Medicine: Past, Present, and Future." Cellular Reprogramming 19, no. 4 (2017): 217–24. http://dx.doi.org/10.1089/cell.2016.0062.

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Deng, Hao, Chun Sun, Yingxin Sun, et al. "Lipid, Protein, and MicroRNA Composition Within Mesenchymal Stem Cell-Derived Exosomes." Cellular Reprogramming 20, no. 3 (2018): 178–86. http://dx.doi.org/10.1089/cell.2017.0047.

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Vydyborets, Stanislav, and Yurii Derpak. "Transplantation Stem Cells: From Definition to Opportunities of Clinical Application." Family Medicine. European Practices, no. 1 (February 28, 2023): 5–10. https://doi.org/10.30841/2786-720X.1.2023.277470.

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The progressive development of embryology, biology, and hematology in the field of experimental research on the biology of SC contribute to the development of new methods and approaches of cellular and tissue therapy for the reatment of pathological conditions and a number of various diseases. To analyze the information about stem cell (SC) biology, which revealed great possibilities of its use as cellular, gene therapy using both embryonic stem cells (ESC) and SC of an adult organism. The application of ESC requires further study of the clinical possibilities of application in clinical practice, which will directly depend on the limits of tolerance in legal and ethical aspects regarding work with embryonic tissues, the development of an appropriate legislative framework for this field of medicine. The materials for processing were published information sources, publications of scientific research. Used methods of systematic and structural-logical analysis, bibliosemantic. It is promising to carry out research on the feasibility of using auto- and allografts of SC hematopoietic tissue obtained from alternative sources, in particular, umbilical cord blood, embryonic liver, bone marrow in clinical transplantation, the development of new transplantation technologies with the use of non-myeloablative modes of conditioning, transplant purification, the use of hematopoietic factors growth of a new generation, vaccination with dendritic cells, etc. Considering the general aspects of the stem cell (self-renewal, differentiation, plasticity, asymmetric division, niche, stromal support), the possibilities of using embryonic stem cells in regenerative medicine and cell therapy open up. The solution to the problem of SC transplantation gives patients a chance for cure and life extension.

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