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1

Deev, R. V. "Cell transplantation for COVID-19 treatment: transmission of stem stomal (mesenchimal) cells." Genes & Cells 15, no. 2 (2020): 10–19. http://dx.doi.org/10.23868/202004012.

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The review presents the modern concept of the pathogenesis of diffuse alveolar damage, including acute respiratory distress sYndrome in coronavirus infection. It has been established that the so-called "cytokine storm”, which consists in the increased release of substances that are biologically active against the vascular wall and effector cells, leading to the progressive damage to endotheliocytes and alveolocytes, the development of alveolar and interstitial pulmonary edema with fatal respiratory failure and coagulopathy. An important factor in interstitial aggression is the appearance of au
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2

Altomare, R., V. Cannella, A. Abruzzo, et al. "Obtaining Mesenchymal Stem Cells From Adipose Tissue Of Murin Origin: Experimental Study." International Journal of Stem Cell Research and Transplantation 2, no. 5 (2014): 86–90. https://doi.org/10.19070/2328- 3548-1400014.

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The aim of this study was to isolate and characterize rat Adipose Derived Mesenchymal Stem Cells (AD-MSCs) in order to evaluate their proliferative potential and their ability to differentiate in different cell types. AD-MSCs and Derived Mesenchymal Stem Cells (BM-MSCs) have the same characteristics in terms of plasticity. The advantage of adipose tissue is that it is an easier accessible source and it offers a large amount of MSCs by less invasive surgical tecniques. MSCs were obtained from subcutaneous adipose tissue of Wistar rats. First of all microbiological controls were m
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3

Childs, Peter G., Stuart Reid, Manuel Salmeron-Sanchez, and Matthew J. Dalby. "Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products." Biochemical Journal 477, no. 17 (2020): 3349–66. http://dx.doi.org/10.1042/bcj20190382.

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Twenty-five years have passed since the first clinical trial utilising mesenchymal stomal/stem cells (MSCs) in 1995. In this time academic research has grown our understanding of MSC biochemistry and our ability to manipulate these cells in vitro using chemical, biomaterial, and mechanical methods. Research has been emboldened by the promise that MSCs can treat illness and repair damaged tissues through their capacity for immunomodulation and differentiation. Since 1995, 31 therapeutic products containing MSCs and/or progenitors have reached the market with the level of in vitro manipulation v
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4

Mohamed Hassin Mohamed, Chairi, Peña Francisco José Huertas, Zurbano Marta Santidrián, Alcalá Tomás Torres, and del Moral Jesús María Villar. "Treatment of perianal fistulae in crohn's disease with mesenchymal stem cells." Annals of Clinical Gastroenterology and Hepatology 6, no. 1 (2022): 006–20. http://dx.doi.org/10.29328/journal.acgh.1001033.

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Crohn's disease is a chronic syndrome of the gastrointestinal tract that produces idiopathic inflammation. Approximately half of the patients develop abscesses and/or fistulas throughout their history that are located, mainly, in the perianal region. Current treatments are based on individualized plans that generally use combined pharmacology for symptomatic relief based on glucocorticoids, immunosuppressants or immunomodulators, antibiotics, anti-inflammatories, probiotics, and antibodies, or surgical therapies such as intestinal resections or ostomizations (colostomy and ileostomy) that tend
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5

Shulha, M. V., and Y. M. Tsarivskaya. "Biotechnological aspects of the use of mesenchymal, embryonic, stormal and induced pluripotent stem cells." Science and Education a New Dimension VI(157), no. 17 (2018): 34–37. http://dx.doi.org/10.31174/send-nt2018-157vi17-08.

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6

Cohen, Shiri Gur, Tomer Itkin, Orit Kollet, et al. "Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway." Blood 122, no. 21 (2013): 456. http://dx.doi.org/10.1182/blood.v122.21.456.456.

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Hematopoeitic stem and progenitor cells (HSPC) dynamically switch between a quiescent, non-motile mode in the bone marrow (BM), to an active state, in which they proliferate, differentiate and egress to the circulation. Injection of the coagulation protease thrombin induced rapid HSPC mobilization to the blood via activation of its major receptor, protease activated receptor 1 (PAR1) on BM hematopoietic and stromal cells. We hypothesized that coagulation factors control stem cells fate in the BM. We examined if thrombin is generated in the murine BM and found by immunohistochemistry prothrombi
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7

Kim, Chul Soo, Sun Uck Song, Moon Hee Lee, et al. "Maternal Clonal Marrow Stromal Cells Expanded by “Subfractionation Culturing Method” Used for the Treatment of Refractory Chronic Graft Versus Host Disease of an Allogeneic Blood Stem Cell Recipient from an Unrelated Donor." Blood 110, no. 11 (2007): 4910. http://dx.doi.org/10.1182/blood.v110.11.4910.4910.

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Abstract We developed “subfractionation culturing method” for rapid establishment of clonal marrow stomal cell (cMSC) lines. The procedure consists of mixing 1 mL of bone marrow aspirate with 15 mL of complete growth medium (Dulbecco’s Modified Eagle’s Medium containing high glucose, 20% fetal bovine serum [FBS], and 1% penicillin/streptomycin), incubation in a 100 mm culture dish for 2 hours at 37° C with 5% CO2 (I2H), transferring cell culture supernatant a new 100 mm dish, I2H, transferring supernatant to a new dish (D1), I2H, transferring supernatant to a new dish (D2), 1 day incubation (I
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8

Geropoulos, Georgios, Kyriakos Psarras, Maria Papaioannou, et al. "The Effectiveness of Adipose Tissue-Derived Mesenchymal Stem Cells Mixed with Platelet-Rich Plasma in the Healing of Inflammatory Bowel Anastomoses: A Pre-Clinical Study in Rats." Journal of Personalized Medicine 14, no. 1 (2024): 121. http://dx.doi.org/10.3390/jpm14010121.

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Introduction: Multiple factors have been linked with increased risk of anastomotic leak in bowel surgery, including infections, inflammatory bowel disease, patient comorbidities and poor surgical technique. The aim of this study was to investigate the positive effect, if any, of adipose derived mesenchymal stem cells (MSCs) mixed with platelet-rich plasma (PRP) in the healing of bowel anastomoses, in an inflammatory environment after establishment of experimental colitis. Materials and Methods: Thirty-five male Wistar rats were divided into five groups of seven animals: normal controls, coliti
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9

Heyman, E., B. Devriendt, D. Elly, and C. De Schauwer. "Mesenchymal Stem/Stromal Cells: MESENCHYMAL STEM/STROMAL CELLS." Cytotherapy 25, no. 6 (2023): S61. http://dx.doi.org/10.1016/s1465-3249(23)00233-5.

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10

Srivatanakul, Petcharin. "Mesenchymal Stem Cells." Bangkok Medical Journal 06, no. 01 (2013): 71–79. http://dx.doi.org/10.31524/bkkmedj.2013.09.015.

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11

Matsuzaki, Yumi. "Mesenchymal stem cells." Inflammation and Regeneration 33, no. 1 (2013): 001–2. http://dx.doi.org/10.2492/inflammregen.33.001.

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12

Ding, Dah-Ching, Woei-Cherng Shyu, and Shinn-Zong Lin. "Mesenchymal Stem Cells." Cell Transplantation 20, no. 1 (2011): 5–14. http://dx.doi.org/10.3727/096368910x.

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13

Roemeling-van Rhijn, Marieke, Willem Weimar, and Martin J. Hoogduijn. "Mesenchymal stem cells." Current Opinion in Organ Transplantation 17, no. 1 (2012): 55–62. http://dx.doi.org/10.1097/mot.0b013e32834ee676.

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14

Minguell, José J., Alejandro Erices, and Paulette Conget. "Mesenchymal Stem Cells." Experimental Biology and Medicine 226, no. 6 (2001): 507–20. http://dx.doi.org/10.1177/153537020122600603.

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15

Williams, Adam R., and Joshua M. Hare. "Mesenchymal Stem Cells." Circulation Research 109, no. 8 (2011): 923–40. http://dx.doi.org/10.1161/circresaha.111.243147.

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16

Caplan, Arnold I. "Mesenchymal Stem Cells." CARTILAGE 1, no. 1 (2009): 6–9. http://dx.doi.org/10.1177/1947603509354992.

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17

Bianco, Paolo. "“Mesenchymal” Stem Cells." Annual Review of Cell and Developmental Biology 30, no. 1 (2014): 677–704. http://dx.doi.org/10.1146/annurev-cellbio-100913-013132.

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18

Roberts, I. "Mesenchymal stem cells." Vox Sanguinis 87, s2 (2004): 38–41. http://dx.doi.org/10.1111/j.1741-6892.2004.00452.x.

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19

Deans, Robert J., and Annemarie B. Moseley. "Mesenchymal stem cells." Experimental Hematology 28, no. 8 (2000): 875–84. http://dx.doi.org/10.1016/s0301-472x(00)00482-3.

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20

Kalervo Väänänen, H. "Mesenchymal stem cells." Annals of Medicine 37, no. 7 (2005): 469–79. http://dx.doi.org/10.1080/07853890500371957.

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21

Short, Brenton, Nathalie Brouard, Teresa Occhiodoro-Scott, Anand Ramakrishnan, and Paul J. Simmons. "Mesenchymal stem cells." Archives of Medical Research 34, no. 6 (2003): 565–71. http://dx.doi.org/10.1016/j.arcmed.2003.09.007.

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22

Caplan, Arnold I. "Mesenchymal stem cells." Journal of Orthopaedic Research 9, no. 5 (1991): 641–50. http://dx.doi.org/10.1002/jor.1100090504.

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23

Zou, Ji-Ping, Sha Huang, Yan Peng, et al. "Mesenchymal Stem Cells/Multipotent Mesenchymal Stromal Cells (MSCs)." International Journal of Lower Extremity Wounds 11, no. 4 (2012): 244–53. http://dx.doi.org/10.1177/1534734612463935.

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24

Venkatesh, Deepak, KP Mohan Kumar, and JyotiB Alur. "Gingival mesenchymal stem cells." Journal of Oral and Maxillofacial Pathology 21, no. 2 (2017): 296. http://dx.doi.org/10.4103/jomfp.jomfp_162_17.

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25

Grabovyi, O. M., N. M. Nevmerzhytska, L. M. Yaremenko, H. B. Kostynskyi, A. S. Demydchuk, and H. Yu Kondaurova. "Mesenchymal stem cells: diversity." Pathologia 20, no. 1 (2023): 76–84. http://dx.doi.org/10.14739/2310-1237.2023.1.272938.

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Mesenchymal stem cells (MSCs) are diverse in terms of plastic, secretory and immunophenotypic features, which is due to the peculiarities of their genetic landscape. MSCs like other body cells are the result of the implementation of genetic information. However, some cells at different stages of histogenesis leave it. Such resident cells in tissues are stem cells. They are in a state of plastic quiescence and their genome does not undergo changes that would lead to commitment / differentiation. Although, these cells show a certain activity, producing various biologically active factors. It is
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26

Falavigna, Asdrubal, and Jaderson Costa da Costa. "Mesenchymal Autologous Stem Cells." World Neurosurgery 83, no. 2 (2015): 236–50. http://dx.doi.org/10.1016/j.wneu.2013.02.026.

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27

Chan, Jerry, Nigel L. Kennea, and Nicholas M. Fisk. "Placental mesenchymal stem cells." American Journal of Obstetrics and Gynecology 196, no. 2 (2007): e18. http://dx.doi.org/10.1016/j.ajog.2006.08.002.

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28

Ringe, Jochen, Christian Kaps, Bernhard Schmitt, et al. "Porcine mesenchymal stem cells." Cell and Tissue Research 307, no. 3 (2002): 321–27. http://dx.doi.org/10.1007/s00441-002-0525-z.

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29

Sharpe, Paul T. "Dental mesenchymal stem cells." Development 143, no. 13 (2016): 2273–80. http://dx.doi.org/10.1242/dev.134189.

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30

Roufosse, C. A., N. C. Direkze, W. R. Otto, and N. A. Wright. "Circulating mesenchymal stem cells." International Journal of Biochemistry & Cell Biology 36, no. 4 (2004): 585–97. http://dx.doi.org/10.1016/j.biocel.2003.10.007.

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31

Son, H., N. Lee, N. Lee, H. Jang, H. Kim, and D. Na. "Mesenchymal Stem/Stromal Cells: CHARACTERISTICS OF HUMAN MESENCHYMAL STEM CELLS UNDER IMMUNOSUPPRESSANTS." Cytotherapy 25, no. 6 (2023): S91—S92. http://dx.doi.org/10.1016/s1465-3249(23)00295-5.

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32

Lye, Kwan Liang, Norshariza Nordin, Sharmili Vidyadaran, and Karuppiah Thilakavathy. "Mesenchymal stem cells: From stem cells to sarcomas." Cell Biology International 40, no. 6 (2016): 610–18. http://dx.doi.org/10.1002/cbin.10603.

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33

Dupuis, Victoria, and Elisa Oltra. "Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells." World Journal of Stem Cells 13, no. 8 (2021): 1094–111. http://dx.doi.org/10.4252/wjsc.v13.i8.1094.

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34

Kordes, Claus, Iris Sawitza, Silke Götze, Diran Herebian, and Dieter Häussinger. "Stellate cells are mesenchymal stem cells." European Journal of Medical Research 19, Suppl 1 (2014): S6. http://dx.doi.org/10.1186/2047-783x-19-s1-s6.

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35

Feng, Jifan, Andrea Mantesso, and Paul T. Sharpe. "Perivascular cells as mesenchymal stem cells." Expert Opinion on Biological Therapy 10, no. 10 (2010): 1441–51. http://dx.doi.org/10.1517/14712598.2010.517191.

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36

Ma, Oscar Ka-Fai, and Koon Ho Chan. "Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes." World Journal of Stem Cells 8, no. 9 (2016): 268. http://dx.doi.org/10.4252/wjsc.v8.i9.268.

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37

Kawata, Yumiko, Eiji Ikami, Junya Nojima, Shoichiro Kokabu, Tetsuya Yoda, and Tsuyoshi Sato. "Effect of Adipose Tissue-Derived Mesenchymal Stem Cells on Irradiated Bone Marrow-Derived Mesenchymal Stem Cells." Journal of Bone Biology and Osteoporosis 4, no. 1 (2018): 94–98. http://dx.doi.org/10.18314/jbo.v4i1.1230.

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Adipose-derived Mesenchymal stem cells have emerged as an attractive alternative source of cell therapy. While radiation therapy is an important application for head and neck cancer, the effect of adipose-derived mesenchymal stem cells on irradiated bone marrow-derived Mesenchymal stem cells is still unclear. Herein, we explored how clinical total radiation dose affect gene expression related with differentiation on murine bone marrow-derived mesenchymal stem cells and how murine adipose-derived mesenchymal stem cells affect irradiated murine bone marrow-derived mesenchymal stem cells. The cli
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38

Tekeli, Senem. "Stem cells; mesenchymal stem cells and current clinical applications." Istanbul Bilim University Florence Nightingale Transplantation Journal 1, no. 2 (2016): 72–83. http://dx.doi.org/10.5606/fng.transplantasyon.2016.013.

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39

Mihaylova, Zornitsa. "Stem cells and mesenchymal stem cell markers." International Journal of Medical Science and Clinical invention 6, no. 08 (2019): 4544–47. http://dx.doi.org/10.18535/ijmsci/v6i8.03.

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Stem cells are undifferentiated cell type characterized by colonogenic ability, self-renewal and multi-lineage differentiation. They are classified into the following categories: embryonic stem cells [ESC], somatic stem cells [or adult stem cells] and induced pluripotent stem cells [iPSC]. Stem cells represent area of interest for wide range of scientists, as they are promising tool for regenerative therapy. Their differentiation ability is significantly affected by various factors of the local environment. Additional research will provide more information about the optimal cell culture condit
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40

Liu, Yanan, Haifeng Wang, Huixin Dou, et al. "Bone regeneration capacities of alveolar bone mesenchymal stem cells sheet in rabbit calvarial bone defect." Journal of Tissue Engineering 11 (January 2020): 204173142093037. http://dx.doi.org/10.1177/2041731420930379.

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Mesenchymal stem cells sheets have been verified as a promising non-scaffold strategy for bone regeneration. Alveolar bone marrow mesenchymal stem cells, derived from neural crest, have the character of easily obtained and strong multi-differential potential. However, the bone regenerative features of alveolar bone marrow mesenchymal stem cells sheets in the craniofacial region remain unclear. The purpose of the present study was to compare the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone (alveolar
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41

Jung, Cho-Rok, Kondabagil R. Kiran, and Byoung S. Kwon. "Mesenchymal stem cells and osteogenesis." Immune Network 1, no. 3 (2001): 179. http://dx.doi.org/10.4110/in.2001.1.3.179.

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42

Jakob, Franz, Catarina Limbert, Tatjana Schilling, Peggy Benisch, Lothar Seefried, and Regina Ebert. "Biology of Mesenchymal Stem Cells." Current Rheumatology Reviews 4, no. 3 (2008): 148–54. http://dx.doi.org/10.2174/157339708785133497.

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43

Liu, Tong Ming. "Stemness of Mesenchymal Stem Cells." Journal of Stem Cell Therapy and Transplantation 1, no. 1 (2017): 071–73. http://dx.doi.org/10.29328/journal.jsctt.1001008.

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44

Natalie L, Payne, and Bernard Claude C. "Mesenchymal stem cells and immunomodulation." Inflammation and Regeneration 34, no. 4 (2014): 165–67. http://dx.doi.org/10.2492/inflammregen.34.165.

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45

Xie, Li, Bonnee Nie, Longxiang Shen, Dongyang Qian, Xin Wang, and Shuanhu Zhou. "Adipocytogenesis of Mesenchymal Stem Cells." Journal of Advances in Health 01, no. 01 (2019): 22–29. http://dx.doi.org/10.3724/sp.j.2640-8686.2019.0021.

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46

O'Donoghue, Keelin, and Jerry Chan. "Human Fetal Mesenchymal Stem Cells." Current Stem Cell Research & Therapy 1, no. 3 (2006): 371–86. http://dx.doi.org/10.2174/157488806778226768.

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47

Ma, S., N. Xie, W. Li, B. Yuan, Y. Shi, and Y. Wang. "Immunobiology of mesenchymal stem cells." Cell Death & Differentiation 21, no. 2 (2013): 216–25. http://dx.doi.org/10.1038/cdd.2013.158.

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48

Gerth, David J., and Seth R. Thaller. "Adipose-Derived Mesenchymal Stem Cells." Journal of Craniofacial Surgery 30, no. 3 (2019): 636–38. http://dx.doi.org/10.1097/scs.0000000000005336.

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49

Tyndall, Alan, and Vito Pistoia. "Mesenchymal stem cells combat sepsis." Nature Medicine 15, no. 1 (2009): 18–20. http://dx.doi.org/10.1038/nm0109-18.

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50

Luger, Dror, Michael J. Lipinski, Peter C. Westman, et al. "Intravenously Delivered Mesenchymal Stem Cells." Circulation Research 120, no. 10 (2017): 1598–613. http://dx.doi.org/10.1161/circresaha.117.310599.

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