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Journal articles on the topic 'Messenger RNA-binding proteins'

Author: Grafiati

Published: 25 January 2025

Last updated: 31 July 2025

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1

Anji, Antje, and Meena Kumari. "Guardian of Genetic Messenger-RNA-Binding Proteins." Biomolecules 6, no. 1 (2016): 4. http://dx.doi.org/10.3390/biom6010004.

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2

Yu, Michael C. "The Role of Protein Arginine Methylation in mRNP Dynamics." Molecular Biology International 2011 (April 7, 2011): 1–10. http://dx.doi.org/10.4061/2011/163827.

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In eukaryotes, messenger RNA biogenesis depends on the ordered and precise assembly of a nuclear messenger ribonucleoprotein particle (mRNP) during transcription. This process requires a well-orchestrated and dynamic sequence of molecular recognition events by specific RNA-binding proteins. Arginine methylation is a posttranslational modification found in a plethora of RNA-binding proteins responsible for mRNP biogenesis. These RNA-binding proteins include both heterogeneous nuclear ribonucleoproteins (hnRNPs) and serine/arginine-rich (SR) proteins. In this paper, I discuss the mechanisms of a

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Schuschel, Konstantin, Matthias Helwig, Stefan Hüttelmaier, Dirk Heckl, Jan-Henning Klusmann, and Jessica I. Hoell. "RNA-Binding Proteins in Acute Leukemias." International Journal of Molecular Sciences 21, no. 10 (2020): 3409. http://dx.doi.org/10.3390/ijms21103409.

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Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest

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Dreyfuss, Gideon, V. Narry Kim, and Naoyuki Kataoka. "Messenger-RNA-binding proteins and the messages they carry." Nature Reviews Molecular Cell Biology 3, no. 3 (2002): 195–205. http://dx.doi.org/10.1038/nrm760.

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Zhang, Jing, Fanghui Ding, Dan Jiao, Qiaozhi Li, and Hong Ma. "The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382091733. http://dx.doi.org/10.1177/1533033820917332.

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RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients with various types of cancer. Although gastric cancer is a relatively frequent and potentially fatal malignancy, the mechanism by which insulin-like growth factor 2 messenger RNA–binding protein 3 regulates the development of this cancer remains unclear. This study aimed to investigate the role and regulatory mechanism of insulin-like growth facto

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Anderson, Paul, and Nancy Kedersha. "RNA granules." Journal of Cell Biology 172, no. 6 (2006): 803–8. http://dx.doi.org/10.1083/jcb.200512082.

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Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. RNA granules contain various ribosomal subunits, translation factors, decay enzymes, helicases, scaffold proteins, and RNA-binding proteins, and they control the localization, stability, and translation of their RNA cargo. We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger

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Akay, Alper, Ashley Craig, Nicolas Lehrbach, et al. "RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let- 7 miRNA pathways in Caenorhabditis elegans." Open Biology 3, no. 11 (2013): 130151. http://dx.doi.org/10.1098/rsob.130151.

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Messenger RNA translation is regulated by RNA-binding proteins and small non-coding RNAs called microRNAs. Even though we know the majority of RNA-binding proteins and microRNAs that regulate messenger RNA expression, evidence of interactions between the two remain elusive. The role of the RNA-binding protein GLD-1 as a translational repressor is well studied during Caenorhabditis elegans germline development and maintenance. Possible functions of GLD-1 during somatic development and the mechanism of how GLD-1 acts as a translational repressor are not known. Its human homologue, quaking (QKI),

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Bier, Katja, Ashley York, and Ervin Fodor. "Cellular cap-binding proteins associate with influenza virus mRNAs." Journal of General Virology 92, no. 7 (2011): 1627–34. http://dx.doi.org/10.1099/vir.0.029231-0.

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The influenza virus RNA polymerase synthesizes three types of RNA: genomic vRNA, anti-genomic cRNA and mRNA. Both vRNA and cRNA are bound by the viral RNA polymerase and nucleoprotein to form ribonucleoprotein complexes. Viral mRNAs are also proposed to be bound by the RNA polymerase to prevent their endonucleolytic cleavage, regulate the splicing of M1 mRNA, and facilitate translation. Here, we used standard immunoprecipitation, biochemical purification and RNA immunoprecipitation assays to investigate the association of viral and host factors with viral mRNA. We found that viral mRNA associa

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9

Chabot, Benoit, and Lulzim Shkreta. "Defective control of pre–messenger RNA splicing in human disease." Journal of Cell Biology 212, no. 1 (2016): 13–27. http://dx.doi.org/10.1083/jcb.201510032.

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Examples of associations between human disease and defects in pre–messenger RNA splicing/alternative splicing are accumulating. Although many alterations are caused by mutations in splicing signals or regulatory sequence elements, recent studies have noted the disruptive impact of mutated generic spliceosome components and splicing regulatory proteins. This review highlights recent progress in our understanding of how the altered splicing function of RNA-binding proteins contributes to myelodysplastic syndromes, cancer, and neuropathologies.

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Idler, R. K., and W. Yan. "Control of Messenger RNA Fate by RNA-Binding Proteins: An Emphasis on Mammalian Spermatogenesis." Journal of Andrology 33, no. 3 (2011): 309–37. http://dx.doi.org/10.2164/jandrol.111.014167.

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11

Guttridge, Katherine Ladner, and L. Dennis Smith. "Xenopus interspersed RNA families, Ocr and XR, bind DNA-binding proteins." Zygote 3, no. 2 (1995): 111–22. http://dx.doi.org/10.1017/s0967199400002483.

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SummaryInterspersed RNA makes up two-thirds of cytoplasmic polyadenylated RNA in Xenopus and sea urchin eggs.Although it has no known function, previous work has suggested that at least one family of interspersed RNA, XR, binds Xenopus oocyte proteins, and can influence the rate of translation. We have used two Xenopus repeat families, Ocr and XR, to explore their protein binding abilities. Ocr RNA binds the same pattern of highly abundant oocyte proteins that XR RNA binds, which are believed to be messenger ribonucleoprotein (mRNP) particle proteins. In addition, we show that Ocr RNA binds th

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Anderson, Kelsi L., and Paul M. Dunman. "Messenger RNA Turnover Processes inEscherichia coli, Bacillus subtilis, and Emerging Studies inStaphylococcus aureus." International Journal of Microbiology 2009 (2009): 1–15. http://dx.doi.org/10.1155/2009/525491.

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The regulation of mRNA turnover is a recently appreciated phenomenon by which bacteria modulate gene expression. This review outlines the mechanisms by which three major classes of bacterialtrans-acting factors, ribonucleases (RNases), RNA binding proteins, and small noncoding RNAs (sRNA), regulate the transcript stability and protein production of target genes. Because the mechanisms of RNA decay and maturation are best characterized inEscherichia coli, the majority of this review will focus on how these factors modulate mRNA stability in this organism. However, we also address the effects of

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Dynan, William S., and Robert Tjian. "Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins." Nature 316, no. 6031 (1985): 774–78. http://dx.doi.org/10.1038/316774a0.

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Bose, Sudeep K., Tapas K. Sengupta, Sumita Bandyopadhyay, and Eleanor K. Spicer. "Identification of Ebp1 as a component of cytoplasmic bcl-2 mRNP (messenger ribonucleoprotein particle) complexes." Biochemical Journal 396, no. 1 (2006): 99–107. http://dx.doi.org/10.1042/bj20051548.

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The 3′-UTR (untranslated region) of bcl-2 mRNA contains an ARE (AU-rich element) that potentially regulates the stability of bcl-2 mRNA in a cell specific fashion. Previous studies have demonstrated that multiple proteins interact with bcl-2 mRNA in HL-60 (human leukaemia-60) cells, potentially contributing to the overexpression of Bcl-2 protein. Treatment of HL-60 cells with taxol or okadaic acid has been shown to induce destabilization of bcl-2 mRNA, which was associated with decreased binding of trans-acting factors to bcl-2 mRNA. Nucleolin has been identified as one of the bcl-2 mRNA-bindi

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Khandjian, Edouard W. "Biology of the fragile X mental retardation protein, an RNA-binding protein." Biochemistry and Cell Biology 77, no. 4 (1999): 331–42. http://dx.doi.org/10.1139/o99-035.

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The fragile X syndrome, an X-linked disease, is the most frequent cause of inherited mental retardation. The syndrome results from the absence of expression of the FMR1 gene (fragile mental retardation 1) owing to the expansion of a CGG trinucleotide repeat located in the 5prime untranslated region of the gene and the subsequent methylation of its CpG island. The FMR1 gene product (FMRP) is a cytoplasmic protein that contains two KH domains and one RGG box, characteristics of RNA-binding proteins. FMRP is associated with mRNP complexes containing poly(A)+mRNA within actively translating polyri

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Aitchison, J. D., G. Blobel, and M. P. Rout. "Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins." Science 274, no. 5287 (1996): 624–27. http://dx.doi.org/10.1126/science.274.5287.624.

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Ray, B. K., T. G. Lawson, R. D. Abramson, W. C. Merrick, and R. E. Thach. "Recycling of messenger RNA cap-binding proteins mediated by eukaryotic initiation factor 4B." Journal of Biological Chemistry 261, no. 25 (1986): 11466–70. http://dx.doi.org/10.1016/s0021-9258(18)67267-9.

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Akman, Hasan O., Hong Zhang, M. A. Q. Siddiqui, William Solomon, Eric L. P. Smith та Olcay A. Batuman. "Response to hypoxia involves transforming growth factor-β2 and Smad proteins in human endothelial cells". Blood 98, № 12 (2001): 3324–31. http://dx.doi.org/10.1182/blood.v98.12.3324.

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Abstract Oxygen deprivation (hypoxia) is a consistent component of ischemia that induces an inflammatory and prothrombotic response in the endothelium. In this report, it is demonstrated that exposure of endothelial cells to hypoxia (1% O2) increases messenger RNA and protein levels of transforming growth factor-β2 (TGF-β2), a cytokine with potent regulatory effects on vascular inflammatory responses. Messenger RNA levels of the TGF-β2 type II membrane receptor, which is a serine threonine kinase, also increased. The stimulatory effect of hypoxia was found to occur at the level of transcriptio

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Coppin, Lucie, Julie Leclerc, Audrey Vincent, Nicole Porchet, and Pascal Pigny. "Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?" International Journal of Molecular Sciences 19, no. 3 (2018): 650. http://dx.doi.org/10.3390/ijms19030650.

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Sanchez, Mayka, Bruno Galy, Bjoern Schwanhaeusser, et al. "Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins." Blood 118, no. 22 (2011): e168-e179. http://dx.doi.org/10.1182/blood-2011-04-343541.

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Abstract Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known IRP-binding mRNAs encode proteins involved in iron uptake, storage, and release as well as heme synthesis. To systematically define the IRE/IRP regulatory network on a transcriptome-wide scale, IRP1/IRE and IRP2/IRE messenger ribonucleoprotein complexes were immunoselected, and the mRNA composition was determined using microarrays. We identify 35 novel mRNAs that bind both IRP1 and IRP2, an

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Calapez, Alexandre, Henrique M. Pereira, Angelo Calado, et al. "The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive." Journal of Cell Biology 159, no. 5 (2002): 795–805. http://dx.doi.org/10.1083/jcb.200203046.

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fAter being released from transcription sites, messenger ribonucleoprotein particles (mRNPs) must reach the nuclear pore complexes in order to be translocated to the cytoplasm. Whether the intranuclear movement of mRNPs results largely from Brownian motion or involves molecular motors remains unknown. Here we have used quantitative photobleaching techniques to monitor the intranuclear mobility of protein components of mRNPs tagged with GFP. The results show that the diffusion coefficients of the poly(A)-binding protein II (PABP2) and the export factor TAP are significantly reduced when these p

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Chapman, Ria M., Caroline L. Tinsley, Matthew J. Hill, et al. "Convergent Evidence That ZNF804A Is a Regulator of Pre-messenger RNA Processing and Gene Expression." Schizophrenia Bulletin 45, no. 6 (2018): 1267–78. http://dx.doi.org/10.1093/schbul/sby183.

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Abstract Genome-wide association studies have linked common variation in ZNF804A with an increased risk of schizophrenia. However, little is known about the biology of ZNF804A and its role in schizophrenia. Here, we investigate the function of ZNF804A using a variety of complementary molecular techniques. We show that ZNF804A is a nuclear protein that interacts with neuronal RNA splicing factors and RNA-binding proteins including RBFOX1, which is also associated with schizophrenia, CELF3/4, components of the ubiquitin-proteasome system and the ZNF804A paralog, GPATCH8. GPATCH8 also interacts w

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Burgute, Bhagyashri D., Vivek S. Peche, Anna-Lena Steckelberg, et al. "NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins." Nucleic Acids Research 42, no. 5 (2013): 3177–93. http://dx.doi.org/10.1093/nar/gkt1311.

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Abstract NKAP is a highly conserved protein with roles in transcriptional repression, T-cell development, maturation and acquisition of functional competency and maintenance and survival of adult hematopoietic stem cells. Here we report the novel role of NKAP in splicing. With NKAP-specific antibodies we found that NKAP localizes to nuclear speckles. NKAP has an RS motif at the N-terminus followed by a highly basic domain and a DUF 926 domain at the C-terminal region. Deletion analysis showed that the basic domain is important for speckle localization. In pull-down experiments, we identified R

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Borchardt, Erin K., Nicole M. Martinez, and Wendy V. Gilbert. "Regulation and Function of RNA Pseudouridylation in Human Cells." Annual Review of Genetics 54, no. 1 (2020): 309–36. http://dx.doi.org/10.1146/annurev-genet-112618-043830.

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Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of noncoding RNA in human cells. The known molecular functions of pseudouridine, which include stabilizing RNA conformations and destabilizing interactions with varied RNA-binding proteins, suggest that RNA pseudouridylation could have widespread effects on RNA metabolism and gene expression. Here, we emphasize how much remains to be learned about the RNA targets of human pseudouridine synthases, their basis for recognizing distinct RNA sequences, and the mechanis

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Wang, Ya-Nan, Chen-Yang Yu, and Hong-Zhong Jin. "RNA N6-Methyladenosine Modifications and the Immune Response." Journal of Immunology Research 2020 (January 21, 2020): 1–6. http://dx.doi.org/10.1155/2020/6327614.

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N6-methyladenosine (m6A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m6A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m6A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m6A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m6A modifications in the innate immune response,

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Ishii, Takashi, Hiroshi Hayakawa, Tatsuhiro Igawa, Takeshi Sekiguchi, and Mutsuo Sekiguchi. "Specific binding of PCBP1 to heavily oxidized RNA to induce cell death." Proceedings of the National Academy of Sciences 115, no. 26 (2018): 6715–20. http://dx.doi.org/10.1073/pnas.1806912115.

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In aerobically growing cells, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG), which induces alteration in their gene expression. We previously demonstrated that the human AUF1 protein binds to 8-oxoG in RNA to induce the selective degradation of oxidized messenger RNA. We herein report that the poly(C)-binding protein PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions. While AUF1 binds to oligoribonucleotides carrying a single 8-oxoG, PCBP1 does not bind to such oligoribonucleotides but instead binds firmly to oligoribonucleotides in whi

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López de Silanes, Isabel, María Paz Quesada, and Manel Esteller. "Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer." Analytical Cellular Pathology 29, no. 1 (2007): 1–17. http://dx.doi.org/10.1155/2007/586139.

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The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enha

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Mamontova, Victoria, Barbara Trifault, and Kaspar Burger. "Compartment-Specific Proximity Ligation Expands the Toolbox to Assess the Interactome of the Long Non-Coding RNA NEAT1." International Journal of Molecular Sciences 23, no. 8 (2022): 4432. http://dx.doi.org/10.3390/ijms23084432.

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The nuclear paraspeckle assembly transcript 1 (NEAT1) locus encodes two long non-coding (lnc)RNA isoforms that are upregulated in many tumours and dynamically expressed in response to stress. NEAT1 transcripts form ribonucleoprotein complexes with numerous RNA-binding proteins (RBPs) to assemble paraspeckles and modulate the localisation and activity of gene regulatory enzymes as well as a subset of messenger (m)RNA transcripts. The investigation of the dynamic composition of NEAT1-associated proteins and mRNAs is critical to understand the function of NEAT1. Interestingly, a growing number of

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Oliveira, Camila, André P. Gerber, Samuel Goldenberg, and Lysangela R. Alves. "Characterization of the RNA-Binding Protein TcSgn1 in Trypanosoma cruzi." Microorganisms 9, no. 5 (2021): 986. http://dx.doi.org/10.3390/microorganisms9050986.

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RNA-binding proteins (RBPs) participate in several steps of post-transcriptional regulation of gene expression, such as splicing, messenger RNA transport, mRNA localization, and translation. Gene-expression regulation in trypanosomatids occurs primarily at the post-transcriptional level, and RBPs play important roles in the process. Here, we characterized the RBP TcSgn1, which contains one RNA recognition motif (RRM). TcSgn1 is a close ortholog of yeast Saccharomyces cerevisiae protein ScSgn1, which plays a role in translational regulation in the cytoplasm. We found that TcSgn1 in Trypanosoma

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Rowlett, Robert M., Carol A. Chrestensen, Melanie J. Schroeder, et al. "Inhibition of tristetraprolin deadenylation by poly(A) binding protein." American Journal of Physiology-Gastrointestinal and Liver Physiology 295, no. 3 (2008): G421—G430. http://dx.doi.org/10.1152/ajpgi.00508.2007.

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Tristetraprolin (TTP) is the prototype for a family of RNA binding proteins that bind the tumor necrosis factor (TNF) messenger RNA AU-rich element (ARE), causing deadenylation of the TNF poly(A) tail, RNA decay, and silencing of TNF protein production. Using mass spectrometry sequencing we identified poly(A) binding proteins-1 and -4 (PABP1 and PABP4) in high abundance and good protein coverage from TTP immunoprecipitates. PABP1 significantly enhanced TNF ARE binding by RNA EMSA and prevented TTP-initiated deadenylation in an in vitro macrophage assay of TNF poly(A) stability. Neomycin inhibi

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Anji, A., and M. Kumari. "NR1 MESSENGER RNA BINDING PROTEINS IN FETAL CORTICAL NEURONS AND CEREBRAL CORTEX OF ADULT MOUSE." Alcoholism: Clinical & Experimental Research 28, Supplement (2004): 38A. http://dx.doi.org/10.1097/00000374-200408002-00191.

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Kaneko, Shuji, Ken-ichi Kato, Shun-ichi Yamagishi, Hiroyuki Sugiyama, and Yasuyuki Nomura. "GTP-binding proteins Gi and Go transplanted onto Xenopus oocyte by rat brain messenger RNA." Molecular Brain Research 3, no. 1 (1987): 11–19. http://dx.doi.org/10.1016/0169-328x(87)90039-8.

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Gao, Jie, Désirée Schatton, Paola Martinelli, et al. "CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins." Journal of Cell Biology 207, no. 2 (2014): 213–23. http://dx.doi.org/10.1083/jcb.201403129.

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Mitochondrial function requires coordination of two genomes for protein biogenesis, efficient quality control mechanisms, and appropriate distribution of the organelles within the cell. How these mechanisms are integrated is currently not understood. Loss of the Clu1/CluA homologue (CLUH) gene led to clustering of the mitochondrial network by an unknown mechanism. We find that CLUH is coregulated both with genes encoding mitochondrial proteins and with genes involved in ribosomal biogenesis and translation. Our functional analysis identifies CLUH as a cytosolic messenger ribonucleic acid (RNA;

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Jacobsen, Julian O. B., Mark D. Allen, Stefan M. V. Freund, and Mark Bycroft. "High-resolution NMR structures of the domains ofSaccharomyces cerevisiaeTho1." Acta Crystallographica Section F Structural Biology Communications 72, no. 6 (2016): 500–506. http://dx.doi.org/10.1107/s2053230x16007597.

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THO is a multi-protein complex involved in the formation of messenger ribonuclear particles (mRNPs) by coupling transcription with mRNA processing and export. THO is thought to be formed from five subunits, Tho2p, Hpr1p, Tex1p, Mft1p and Thp2p, and recent work has determined a low-resolution structure of the complex [Poulsenet al.(2014),PLoS One,9, e103470]. A number of additional proteins are thought to be involved in the formation of mRNP in yeast, including Tho1, which has been shown to bind RNAin vitroand is recruited to actively transcribed chromatinin vivoin a THO-complex and RNA-depende

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Robert, Claude, Marie-France Palin, Frederick G. Silversides, Robert M. Mckay, and Ghislain Pelletier. "Messenger RNA levels of growth factors, ligands, receptors, and proteins affecting lipid metabolism in pigs." Canadian Journal of Animal Science 80, no. 4 (2000): 559–67. http://dx.doi.org/10.4141/a00-029.

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The Northern blot technique was used for mRNA phenotyping of 19 growth factors, ligands, receptors, and proteins involved in lipid metabolism in two populations of pigs with different fat deposition capabilities. The mRNA levels were measured in backfat, liver, and muscle tissue at different slaughter weights, taking backfat thickness, gender and breed of the animals into consideration. Of all the RNA patterns measured in the Landrace population, only the mRNA transcript level of low density lipoprotein receptor-related protein (also called alpha 2-macroglobulin receptor) was associated with t

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Shao, Ming, Tong Lu, Chong Zhang, Yi-Zhuang Zhang, Shu-Hui Kong, and De-Li Shi. "Rbm24 controls poly(A) tail length and translation efficiency of crystallin mRNAs in the lens via cytoplasmic polyadenylation." Proceedings of the National Academy of Sciences 117, no. 13 (2020): 7245–54. http://dx.doi.org/10.1073/pnas.1917922117.

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Lens transparency is established by abundant accumulation of crystallin proteins and loss of organelles in the fiber cells. It requires an efficient translation of lens messenger RNAs (mRNAs) to overcome the progressively reduced transcriptional activity that results from denucleation. Inappropriate regulation of this process impairs lens differentiation and causes cataract formation. However, the regulatory mechanism promoting protein synthesis from lens-expressed mRNAs remains unclear. Here we show that in zebrafish, the RNA-binding protein Rbm24 is critically required for the accumulation o

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Bembich, Sara, Jeremias S. Herzog, Laura De Conti, et al. "Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation." Nucleic Acids Research 42, no. 5 (2013): 3362–71. http://dx.doi.org/10.1093/nar/gkt1343.

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AbstractTDP-43 is a nuclear protein involved in many aspects of RNA metabolism. To ensure cellular viability, its expression levels within cells must be tightly regulated. We have previously demonstrated that TDP-43 autoregulation occurs through the activation of a normally silent intron in its 3′-UTR sequence that results in the use of alternative polyadenylation sites. In this work, we analyse which is the dominant event in autoregulation: the recognition of the splice sites of 3′-UTR intron 7 or the intrinsic quality of the alternative polyadenylation sites. A panel of minigene constructs w

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Dinur, Maya, Rachel Kilav, Alin Sela-Brown, Helene Jacquemin-Sablon, and Tally Naveh-Many. "In Vitro Evidence that Upstream of N-ras Participates in the Regulation of Parathyroid Hormone Messenger Ribonucleic Acid Stability." Molecular Endocrinology 20, no. 7 (2006): 1652–60. http://dx.doi.org/10.1210/me.2005-0333.

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Abstract Calcium and phosphate regulate PTH gene expression posttranscriptionally through the binding of trans-acting factors to a defined cis-acting instability element in the PTH mRNA 3′-untranslated region (UTR). We have previously defined AU-rich binding factor 1 as a PTH mRNA binding and stabilizing protein. We have now identified, by affinity chromatography, Upstream of N-ras (Unr) as another PTH mRNA 3′-UTR binding protein. Recombinant Unr bound the PTH 3′-UTR transcript, and supershift experiments with antibodies to Unr showed that Unr is part of the parathyroid RNA binding complex. Fi

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Oyejobi, Greater Kayode, Xiaodan Yan, Piotr Sliz, and Longfei Wang. "Regulating Protein–RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway." International Journal of Molecular Sciences 25, no. 7 (2024): 3585. http://dx.doi.org/10.3390/ijms25073585.

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Originally discovered in C. elegans, LIN28 is an evolutionarily conserved zinc finger RNA-binding protein (RBP) that post-transcriptionally regulates genes involved in developmental timing, stem cell programming, and oncogenesis. LIN28 acts via two distinct mechanisms. It blocks the biogenesis of the lethal-7 (let-7) microRNA (miRNA) family, and also directly binds messenger RNA (mRNA) targets, such as IGF-2 mRNA, and alters downstream splicing and translation events. This review focuses on the molecular mechanism of LIN28 repression of let-7 and current strategies to overcome this blockade fo

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Singh, Gatikrushna, Sarah E. Fritz, Bradley Seufzer, and Kathleen Boris-Lawrie. "The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR." Journal of Biological Chemistry 295, no. 22 (2020): 7763–73. http://dx.doi.org/10.1074/jbc.ra119.012005.

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One long-standing knowledge gap is the role of nuclear proteins in mRNA translation. Nuclear RNA helicase A (DHX9/RHA) is necessary for the translation of the mRNAs of JUND (JunD proto-oncogene AP-1 transcription factor subunit) and HIV-1 genes, and nuclear cap-binding protein 1 (NCBP1)/CBP80 is a component of HIV-1 polysomes. The protein kinase mTOR activates canonical messenger ribonucleoproteins by post-translationally down-regulating the eIF4E inhibitory protein 4E-BP1. We posited here that NCBP1 and DHX9/RHA (RHA) support a translation pathway of JUND RNA that is independent of mTOR. We p

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Jin, Suk-Won, Nancy Arno, Adam Cohen, et al. "In Caenorhabditis elegans, the RNA-Binding Domains of the Cytoplasmic Polyadenylation Element Binding Protein FOG-1 Are Needed to Regulate Germ Cell Fates." Genetics 159, no. 4 (2001): 1617–30. http://dx.doi.org/10.1093/genetics/159.4.1617.

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Abstract FOG-1 controls germ cell fates in the nematode Caenorhabditis elegans. Sequence analyses revealed that FOG-1 is a cytoplasmic polyadenylation element binding (CPEB) protein; similar proteins from other species have been shown to bind messenger RNAs and regulate their translation. Our analyses of fog-1 mutations indicate that each of the three RNA-binding domains of FOG-1 is essential for activity. In addition, biochemical tests show that FOG-1 is capable of binding RNA sequences in the 3′-untranslated region of its own message. Finally, genetic assays reveal that fog-1 functions zygot

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Katoh, Y., I. Komuro, F. Takaku, H. Yamaguchi, and Y. Yazaki. "Messenger RNA levels of guanine nucleotide-binding proteins are reduced in the ventricle of cardiomyopathic hamsters." Circulation Research 67, no. 1 (1990): 235–39. http://dx.doi.org/10.1161/01.res.67.1.235.

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Ravel-Chapuis, Aymeric, Guy Bélanger, Ramesh S. Yadava, et al. "The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing." Journal of Cell Biology 196, no. 6 (2012): 699–712. http://dx.doi.org/10.1083/jcb.201108113.

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In myotonic dystrophy type 1 (DM1), dystrophia myotonica protein kinase messenger ribonucleic acids (RNAs; mRNAs) with expanded CUG repeats (CUGexp) aggregate in the nucleus and become toxic to cells by sequestering and/or misregulating RNA-binding proteins, resulting in aberrant alternative splicing. In this paper, we find that the RNA-binding protein Staufen1 is markedly and specifically increased in skeletal muscle from DM1 mouse models and patients. We show that Staufen1 interacts with mutant CUGexp mRNAs and promotes their nuclear export and translation. This effect is critically dependen

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Pascual, Rosa, Judit Martín, Fernando Salvador, et al. "The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer." Science Advances 6, no. 20 (2020): eaax3868. http://dx.doi.org/10.1126/sciadv.aax3868.

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Organogenesis is directed by coordinated cell proliferation and differentiation programs. The hierarchical networks of transcription factors driving mammary gland development and function have been widely studied. However, the contribution of posttranscriptional gene expression reprogramming remains largely unexplored. The 3′ untranslated regions of messenger RNAs (mRNAs) contain combinatorial ensembles of cis-regulatory elements that define transcript-specific regulation of protein synthesis through their cognate RNA binding proteins. We analyze the contribution of the RNA binding cytoplasmic

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H.B, Kiran Kumar, Priya M. D, Mahalakshmi B.R, B. K. Manjunath, and Tenkanidiyooru Ramamoorthy Prashith Kekuda. "RNA Sensing in Cells: An Update of Its Mechanisms, Disorders and Therapeutics." Annual Research & Review in Biology 40, no. 5 (2025): 90–118. https://doi.org/10.9734/arrb/2025/v40i52244.

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The workhorses of a cell are the protein-coding RNA and the non-coding RNA (ncRNA). Many of these RNAs and the RNA-binding proteins that are linked to them, known as ribonucleoprotein complexes (RNPs), are essential for cellular processes. Accurate production of many protein-coding RNAs (messenger RNAs [mRNAs]) and (noncoding RNAs[ncRNAs]) is essential for cells to function where they carry out functions such as translation, transcription, and RNA processing. These process require high fidelity due to the abundance of RNA-binding proteins and due to cellular insults both endogenous and exogeno

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-, Abhya Bhardwaj, Neelmani -, and Charanjit Kaur -. "Recent Advances on Bioactive Molecules Acting on RNA and RNA Binding Proteins." International Journal For Multidisciplinary Research 6, no. 3 (2024). http://dx.doi.org/10.36948/ijfmr.2024.v06i03.21115.

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This review discusses the binding of biologically active molecules to RNA, a crucial component in understanding the molecular basis of life. RNA is replicated from DNA by RNA polymerase and is essential for protein formation. Three types of cellular RNA are messenger RNA (mRNA), ribosomal RNA (rRNA), and soluble RNA (sRNA). The impact of altered RNA binding proteins on human diseases is also discussed. The article also discusses the function of human Pol III in transcription of noncoding RNAs with immuno stimulatory effects, which can promote antiviral immunity. The intricacies of RNA and RNA

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Wheeler, Joshua R., Oscar N. Whitney, Thomas O. Vogler, et al. "RNA-binding proteins direct myogenic cell fate decisions." eLife 11 (June 13, 2022). http://dx.doi.org/10.7554/elife.75844.

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RNA-binding proteins (RBPs), essential for skeletal muscle regeneration, cause muscle degeneration and neuromuscular disease when mutated. Why mutations in these ubiquitously expressed RBPs orchestrate complex tissue regeneration and direct cell fate decisions in skeletal muscle remains poorly understood. Single-cell RNA-sequencing of regenerating Mus musculus skeletal muscle reveals that RBP expression, including the expression of many neuromuscular disease-associated RBPs, is temporally regulated in skeletal muscle stem cells and correlates with specific stages of myogenic differentiation. B

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Dallastella, Marianna, Willian Klassen de Oliveira, Marcio L. Rodrigues, Samuel Goldenberg, and Lysangela R. Alves. "The characterization of RNA-binding proteins and RNA metabolism-related proteins in fungal extracellular vesicles." Frontiers in Cellular and Infection Microbiology 13 (September 14, 2023). http://dx.doi.org/10.3389/fcimb.2023.1247329.

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RNA-binding proteins (RBPs) are essential for regulating RNA metabolism, stability, and translation within cells. Recent studies have shown that RBPs are not restricted to intracellular functions and can be found in extracellular vesicles (EVs) in different mammalian cells. EVs released by fungi contain a variety of proteins involved in RNA metabolism. These include RNA helicases, which play essential roles in RNA synthesis, folding, and degradation. Aminoacyl-tRNA synthetases, responsible for acetylating tRNA molecules, are also enriched in EVs, suggesting a possible link between these enzyme

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Bakhtiar, Dara, and Igor Vorechovsky. "Copper-binding proteins and exonic splicing enhancers and silencers." Metallomics, May 1, 2024. http://dx.doi.org/10.1093/mtomcs/mfae023.

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Abstract Eukaryotic DNA codes not only for proteins but contains a wealth of information required for accurate splicing of messenger RNA precursors and inclusion of constitutively or alternatively spliced exons in mature transcripts. This ‘auxiliary’ splicing code has been characterized as exonic splicing enhancers and silencers (ESE and ESS). The exact interplay between protein and splicing codes is, however, poorly understood. Here, we show that exons encoding copper-coordinating amino acids in human cuproproteins lack ESEs and/or have an excess of ESSs, yet RNA sequencing and expressed sequ

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Carballo, E. "Feedback Inhibition of Macrophage Tumor Necrosis Factor- Production by Tristetraprolin." August 14, 1998. https://doi.org/10.1126/science.281.5379.1001.

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Tumor necrosis factor–α (TNF-α) is a major mediator of both acute and chronic inflammatory responses in many diseases. Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys-His (CCCH) zinc finger proteins, inhibited TNF-α production from macrophages by destabilizing its messenger RNA. This effect appeared to result from direct TTP binding to the AU-rich element of the TNF-α messenger RNA. TTP is a cytosolic protein in these cells, and its biosynthesis was induced by the same agents that stimulate TNF-α production, including TNF-α itself. These findings identify TTP as a component of a

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