Relevant bibliographies by topics / Messenger RNA couple

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Messenger RNA couple'

Author: Grafiati
Published: 30 November 2024
Last updated: 31 July 2025

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Journal articles on the topic "Messenger RNA couple"

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Al Fayez, Nojoud, Majed S. Nassar, Abdullah A. Alshehri, et al. "Recent Advancement in mRNA Vaccine Development and Applications." Pharmaceutics 15, no. 7 (2023): 1972. http://dx.doi.org/10.3390/pharmaceutics15071972.

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Messenger RNA (mRNA) vaccine development for preventive and therapeutic applications has evolved rapidly over the last decade. The mRVNA vaccine has proven therapeutic efficacy in various applications, including infectious disease, immunotherapy, genetic disorders, regenerative medicine, and cancer. Many mRNA vaccines have made it to clinical trials, and a couple have obtained FDA approval. This emerging therapeutic approach has several advantages over conventional methods: safety; efficacy; adaptability; bulk production; and cost-effectiveness. However, it is worth mentioning that the deliver
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Oohayyed, N. A., M. M. Mohammed, A. M. Al-Rahim, R. N. Al Chalabi, S. A. Shaban, and A. A. J. Suleiman. "Identification of key miRNAs as regulatory biomarkers of gonadotropins leading to infertility in males." Obstetrics, Gynecology and Reproduction 17, no. 5 (2023): 607–24. http://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2023.398.

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Introduction. Infertility is a highly fatal reproductive system disorder that affects the ability of a couple to reproduce. Over the past decades, a drastic uplift has been recorded in infertility cases among males ranging from 20 to 70 % indicating spermatogenesis impairment.Aim: to identify key microRNAs (miRNAs) as regulatory biomarkers of gonadotropins involved in dysregulation of fertility-related genes to propose potential therapeutic strategies that would combat the action of oncogenic miRNAs (oncomiRs).Materials and Methods. Interaction analysis was performed between miRNAs and fertili
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Gong, Congcong, Yang Hu, Mao Zhou, et al. "Identification of specific modules and hub genes associated with the progression of gastric cancer." Carcinogenesis 40, no. 10 (2019): 1269–77. http://dx.doi.org/10.1093/carcin/bgz040.

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Abstract Gastric cancer (GC) has high morbidity and mortality rates worldwide. Abundant literature has reported several individual genes and their related pathways intimately involved in tumor progression. However, little is known about GC progression at the gene network level. Therefore, understanding the underlying mechanisms of pathological transition from early stage to late stage is urgently needed. This study aims to identify potential vital genes and modules involved in the progression of GC. To understand the gene regulatory network of GC progression, we analyzed micro RNAs and messeng
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Weber, Ramona, Min-Yi Chung, Csilla Keskeny, et al. "4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay." Cell Reports 33, no. 2 (2020): 108262. http://dx.doi.org/10.1016/j.celrep.2020.108262.

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Hanjin, Cui, Liu Tao, Li Pengfei, et al. "Altered Long Noncoding RNA and Messenger RNA Expression in Experimental Intracerebral Hemorrhage - a Preliminary Study." Cellular Physiology and Biochemistry 45, no. 3 (2018): 1284–301. http://dx.doi.org/10.1159/000487464.

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Background/Aims: Functional recovery in the chronic phase is a difficult problem in intracerebral hemorrhage (ICH) treatment. Long noncoding RNAs (lncRNAs) are demonstrated to be involved in central nervous system (CNS) disorders. However, the roles of lncRNAs in post-ICH injury and repair are poorly understood, especially those that may be attributed to long-term neurological deficit. The present study depicted the lncRNA and messenger RNA (mRNA) profile by microarray at late stage after an experimental ICH. Methods: LncRNA and mRNA microarray was used to first identify differentially express
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Estevez, Mariana, Rui Li, Biplab Paul, et al. "Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells." RNA 28, no. 5 (2022): 697–710. http://dx.doi.org/10.1261/rna.079043.121.

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The human immunodeficiency virus type 1 (HIV-1) encodes multiple RNA molecules. Transcripts that originate from the proviral 5′ long terminal repeat (LTR) function as messenger RNAs for the expression of 16 different mature viral proteins. In addition, HIV-1 expresses an antisense transcript (Ast) from the 3′LTR, which has both protein-coding and noncoding properties. While the mechanisms that regulate the coding and noncoding activities of Ast remain unknown, post-transcriptional modifications are known to influence RNA stability, interaction with protein partners, and translation capacity. H
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Yang, Jing, Ying Cao, and Ligeng Ma. "Co-Transcriptional RNA Processing in Plants: Exploring from the Perspective of Polyadenylation." International Journal of Molecular Sciences 22, no. 7 (2021): 3300. http://dx.doi.org/10.3390/ijms22073300.

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Most protein-coding genes in eukaryotes possess at least two poly(A) sites, and alternative polyadenylation is considered a contributing factor to transcriptomic and proteomic diversity. Following transcription, a nascent RNA usually undergoes capping, splicing, cleavage, and polyadenylation, resulting in a mature messenger RNA (mRNA); however, increasing evidence suggests that transcription and RNA processing are coupled. Plants, which must produce rapid responses to environmental changes because of their limited mobility, exhibit such coupling. In this review, we summarize recent advances in
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Liu, Yaojuan, Yesenia Rodriguez, Robert L. Ross, et al. "RNA abasic sites in yeast and human cells." Proceedings of the National Academy of Sciences 117, no. 34 (2020): 20689–95. http://dx.doi.org/10.1073/pnas.2011511117.

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RNA abasic sites and the mechanisms involved in their regulation are mostly unknown; in contrast, DNA abasic sites are well-studied. We found surprisingly that, in yeast and human cells, RNA abasic sites are prevalent. When a base is lost from RNA, the remaining ribose is found as a closed-ring or an open-ring sugar with a reactive C1′ aldehyde group. Using primary amine-based reagents that react with the aldehyde group, we uncovered evidence for abasic sites in nascent RNA, messenger RNA, and ribosomal RNA from yeast and human cells. Mass spectroscopic analysis confirmed the presence of RNA a
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Grüschow, Sabine, Catherine S. Adamson, and Malcolm F. White. "Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector." Nucleic Acids Research 49, no. 22 (2021): 13122–34. http://dx.doi.org/10.1093/nar/gkab1190.

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Abstract Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second messenger molecules, activating a variety of effector nucleases that degrade nucleic acids to provide immunity. The prophage-encoded Vibrio metoecus type III-B (VmeCmr) locus is uncharacterised, lacks the HD nuclease domain in Cas10 and encodes a NucC DNA nuclease effector that is also found associated with Cyclic-oligonucleotide-based anti-phage signalling systems (CBASS). Here we demonstrate that VmeCmr is acti
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Stephan, W., and D. A. Kirby. "RNA folding in Drosophila shows a distance effect for compensatory fitness interactions." Genetics 135, no. 1 (1993): 97–103. http://dx.doi.org/10.1093/genetics/135.1.97.

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Abstract Phylogenetic-comparative analysis was used to construct a secondary structure of Adh precursor messenger RNA (pre-mRNA) in Drosophila. The analysis revealed that the rate of coevolution of base-pairing residues decreases with their physical distance. This result is in qualitative agreement with a model of compensatory fitness interactions which assumes that mutations are individually deleterious but become harmless (neutral) in appropriate combinations. This model predicts that coupled mutations can become fixed in a population under mutation pressure and random genetic drift, when th
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Dissertations / Theses on the topic "Messenger RNA couple"

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Levacher, Corentin. "Le déséquilibre ARΝ messager/ARΝ circulaire : nοuveau biοmarqueur en génétique sοmatique et nοuveau facteur de prédispοsitiοn en génétique cοnstitutiοnnelle?" Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR045.

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Les ARN circulaires (ARNcirc), produits du rétro-épissage, sont une nouvelle classe émergente d’ARN impliquée dans diverses maladies et notamment le cancer. Ces ARNcirc, par leurs multiples fonctions, peuvent moduler les niveaux des ARN messagers (ARNm), transcrits linéaires finement régulés. Etant donné que physiologiquement un équilibre s’opère entre ces deux types de transcrits, nous faisons l’hypothèse qu’une perturbation des niveaux de ce couple ARNcirc-ARNm joue un rôle dans la tumorigenèse. Pour tester cette hypothèse, nous avons développé SEALigHTS (Splice and Expression Analyses by ex
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Liska, Olga. "Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ba9454b8-4498-42c8-bc4c-16dd971af164.

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The CCCTC-binding factor (CTCF) is a versatile, multifunctional zinc-finger protein involved in a broad spectrum of cellular functions. In mammalian cells, CTCF functions together with the Cohesin complex, an essential regulator of sister chromatid cohesion. Together, CTCF and Cohesin have been shown to regulate gene expression at a genome-wide level in mammalian cells. In the yeast Saccharomyces pombe, Cohesin has been implicated in transcription termination of convergently transcribed genes, in a cell cycle dependent manner. The aim of this thesis was to investigate the possibility of direct
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"Characterization of an orphan G protein-coupled receptor mas-induced tumor formation." Thesis, 2005. http://library.cuhk.edu.hk/record=b6074087.

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Ectopic and over-expression of G protein-coupled receptor (GPCR) have been reported to induce tumor formation. Mas protein is a member of GPCR family and was originally isolated from human epidermoid carcinoma. It was demonstrated that mas mRNA was abundantly expressed in human and rat brains by in situ hybridization and RNase protection assays. However, cellular mechanism that leads to such tumorigenic transformation is still an open question.<br>In order to identify the cellular mechanism of mas-induced tumor formation, a full-length mas cDNA was cloned into a mammalian expression vector pFR
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Book chapters on the topic "Messenger RNA couple"

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Theodorakis, Nicholas G., and Don W. Cleveland. "Translationally Coupled Degradation of Tubulin mRNA." In Control of Messenger RNA Stability. Elsevier, 1993. http://dx.doi.org/10.1016/b978-0-08-091652-1.50014-1.

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Majeed Shah, Ishteyaq, Mashooq Ahmad Dar, Kaiser Ahmad Bhat, Tashook Ahmad Dar, Fayaz Ahmad, and Syed Mudasir Ahmad. "Long Non-Coding RNAs: Biogenesis, Mechanism of Action and Role in Different Biological and Pathological Processes." In Recent Advances in Non-Coding RNAs [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104861.

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RNA or ribonucleic acid constitutes of nucleotides, which are ribose sugars coupled to nitrogenous bases and phosphate groups. Nitrogenous bases include adenine, guanine, cytosine and uracil. Messenger RNA, ribosomal RNA and Transfer RNA are three main types of RNA that are involved in protein synthesis. Apart from its primary role in synthesis of protein, RNA comes in variety of forms like snRNA, miRNA, siRNA, antisense RNA, LncRNA etc., that are involved in DNA replication, post-transcriptional modification, and gene regulation etc. LncRNAs regulate gene expression by various ways including
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Salunga, Ranelle c., and Hongqing Guo. "Gene expression analysis via cDNA microarrays of laser capture microdissected cells from fixed tissue." In DNA Microarrays. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780199637775.003.0007.

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Abstract The enormous number of DNA and mRNA sequences available to researchers, coupled with cDNA microarray technology, now allows for gene expression to be studied on a massive scale. Using microarrays, thousands of genes from organisms such as S. cerevisiae (1, 2) and A. thaliana (3), as well as those from mammalian species (4), have been analysed. However, most methods that have been described to date have relied on acquiring microgram quantities of messenger RNA or poly(A) RNA from pure populations of cells, in order to synthesize cDNA probes (1-6).
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Tsareva, Jan Van Duin Nina. "Single-Stranded RNA Phages." In The Bacteriophages. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195168778.003.0015.

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Abstract The single-stranded RNA coliphages were discovered by Tim Loeb and Norton Zinder in 1961 as the result of a search for phages whose infection cycle depends on E. coli F-pili, normally used for bacterial conjugation. Loeb and Zinder plated filtered samples of raw New York City sewage on E. coli strains and screened for phages that would produce plaques on male (F) but not female (F-) bacteria. The first isolate, named f1, turned out to be a filamentous phage with a single-stranded DNA genome; the second isolate, named f2, was an RNA-containing phage. Since f2 made clear plaques, Loeb a
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Duin, Jan Van, and Nina Tsareva. "Single-Stranded RNA Phages." In The Bacteriophages. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195148503.003.0015.

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Abstract The single-stranded RNA coliphages were discovered by Tim Loeb and Norton Zinder in 1961 as the result ofa search for phages whose infection cycle depends on E. coli F-pili, normally used for bacterial conjugation. Loeb and Zinder plated filtered samples of raw New York City sewage on E. coli strains and screened for phages that would produce plaques on male (Fþ) but not female (F-) bacteria. The first isolate, named f1, turned out to be a filamentous phage with a single-stranded DNA genome; the second isolate, named f2, was an RNA-containing phage. Since f2 made clear plaques, Loeb a
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Fusco, Dahlene, Edouard Bertrand, and Robert H. Singer. "Messenger RNA Imaging in Living Cells for Biomedical Research." In Biomedical Optical Imaging. Oxford University PressNew York, NY, 2009. http://dx.doi.org/10.1093/oso/9780195150445.003.0004.

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Abstract Recent advances in messenger RNA (mRNA) visualization technology have placed biomedical imaging at an interface between molecular biology and cellular biology. It is now increasingly possible to study in vivo gene expression at the transcript level. Analyses of mRNA expression, movement, interactions, and localization will enhance understanding of cellular responses to various conditions and will complement studies of protein expression. Live cell mRNA imaging technology can add new information about where and when transcription and translation occur, as well as provide a single cell
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Chen, R., and D. Fink. "Computing the Structure of Large Complexes: Modeling the 16S Ribosoma RNA." In Biological NMR Spectroscopy. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195094688.003.0025.

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Ribosomes are the sites of messenger RNA (mRNA) translation to protein, and thus are crucial to the normal functioning of all cells. These ribonucleoprotein particles are composed of a small (30S) subunit and a large (50S) subunit. The 30S subunit, in turn, is composed of a strand of RNA (16S rRNA) and 21 proteins ranging in molecular weight from 9 kD to 61 kD. Studies have demonstrated that ribosomal RNA is necessary for normal ribosome function and protein production (Dahlberg, 1989; Noller, 1991). In particular, 16S rRNA is essential for normal assembly and function of the 30S subunit, whic
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Gerfen, Charles R., W. Scott Young, and Piers Emson. "In situ hybridization histochemistry with oligonucleotides for localization of messenger RNA in neurones." In Experimental Neuroanatomy. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780199633265.003.0008.

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Abstract In situ hybridization histochemical (ISHH) localization of messenger RNA transcripts (mRNA) provides a powerful technique for characterizing the bio chemical phenotype of neurones in the brain (1). With the growing list of characterized mRNAs encoding proteins and neuropeptide precursors the utility of ISHH for the study of neural system organization and function has increased at a phenomenal rate. Included in the list of available probes are those directed against a variety of neurotransmitter and neuropeptide receptors, including G-protein coupled receptors and ion channel receptors
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Semenza, Gregg L. "Gene Expression and Transcriptional Regulation." In Transcription Factors and Huinan Disease. Oxford University PressNew York, NY, 1998. http://dx.doi.org/10.1093/oso/9780195112399.003.0001.

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Abstract To ensure that the subsequent discussions of transcriptional regulation and molecular pathophysiology will be accessible to those not well versed in this literature, a brief overview will be presented first. Whereas molecular geneticists may wish to forgo this introductory course and proceed directly to the second half of the chapter (beginning with “The Transcription Initiation Complex”), the uninitiated should not do so until the definitions and organizing principles in the first three sections have been thoroughly digested. If additional introductory material is needed, a basic tex
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Conference papers on the topic "Messenger RNA couple"

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Price, Andy, Laura Acuña Álvarez, Corinne Whitby, and Jan Larsen. "Detection of SRP Activity by Quantification of mRNA for the Dissimilatory (Bi) Sulfite Reductase Gene (dsrA) by Reverse Transcription Quantitative PCR." In CORROSION 2010. NACE International, 2010. https://doi.org/10.5006/c2010-10253.

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Abstract Molecular biological methods have been used for some years to identify and quantify active microorganisms present in a commercial oil reservoir where biogenic sulfide production is routinely controlled by nitrate injection. In order to gain a more complete understanding of the effects of nitrate injection on the activity of sulfate reducing prokaryotes (SRP, (which encompasses sulfate reducing Bacteria (SRB)) and sulfate reducing Archaea (SRA)), the mRNA for dsrA present in produced water samples was quantified by reverse transcription quantitative PCR (RT-qPCR); mRNA for dsrA should
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Verdugo, Anael, and Richard H. Rand. "Delay Differential Equations in the Dynamics of Gene Copying." In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-34214.

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We analyze a model of gene transcription and protein synthesis which has been previously presented in the biological literature. The model takes the form of an ODE (ordinary differential equation) coupled to a DDE (delay differential equation), the state variables being concentrations of messenger RNA and protein. The delay is assumed to depend on the concentration of mRNA and is therefore state-dependent. Linear analysis gives a critical time delay beyond which a periodic motion is born in a Hopf bifurcation. Lindstedt’s method is applied to the nonlinear system, resulting in closed form appr
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Wu, Q. Y., B. R. Bahnak, L. Coulombel, J. P. Caen, G. Pietu, and D. Meyer. "VON WILLEBRAND FACTOR mRNA IS SEVERELY REDUCED IN PIGS WITH HOMOZYGOUS VON WILLEBRAND DISEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644113.

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Porcine von Willebrand disease (vWD), an autosomal recessive disorder, is similar to some of the severe forms of vWD in humans and is characterized by a prolonged bleeding time and very low or undetectable amounts of von Willebrand factor (vWF) antigen and activity in plasma, platelets and endothelial cells. The molecular events that control the lack of expression of vWF in the vWD pigs is not known and could be at the transcriptional or post-transcriptional level. Lungs from normal and two homozygous vWD pigs were extracted immediately after harvesting of the animals and placed on dry ice. Ti
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Weitz, C., Y. Miyake, K. Shinzato, E. Montag, and J. Nathans. "Studies on the molecular genetics of tritanopia." In OSA Annual Meeting. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oam.1990.fm3.

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Tritanopia differs fundamentally from other inherited anomalies of color vision. Its autosomal dominant tranmission1 implies a mechanism unlike that of protanopia or deuteranopia. Because people with tritanopis lack a measurable blue-cone electroretinographic response,2 the defect is likely localized within blue-cone photoreceptors. These findings suggest that a mutant gene product actively interferes with blue-cone function or viability. Could a mutation in the gene encoding the blue-sensitive visual pigment3 be responsible for tritanopia? To test this hypothesis we have used the polymerase c
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Reports on the topic "Messenger RNA couple"

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Lindsay, Denise, J. Mylroie, Kurt Gust, Elijah Cowan, and Richard Lance. Investigation of environmental messenger RNA (e-mRNA) for detection of genes sensitive to PFOS exposure in zebrafish (Danio rerio). Engineer Research and Development Center (U.S.), 2025. https://doi.org/10.21079/11681/49841.

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Environmental RNA (eRNA) is gaining ground as an environmental monitoring and assessment tool. Whereas environmental DNA is mainly utilized for species detection, and sometimes population size estimation, eRNA potentially provides additional scales or classes of inference. eRNA’s comparatively more rapid signal decay rates provide narrower temporal windows for species presence, while detection of messenger RNAs or other cell regulatory RNAs in environmental samples could provide evidence of genomic responses to environmental stressors. We tested select environmental messenger RNAs (e-mRNAs) of
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Levin, Ilan, John W. Scott, Moshe Lapidot, and Moshe Reuveni. Fine mapping, functional analysis and pyramiding of genes controlling begomovirus resistance in tomato. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594406.bard.

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Abstract. Tomato yellow leaf curl virus (TYLCV), a monopartitebegomovirus, is one of the most devastating viruses of cultivated tomatoes and poses increasing threat to tomato production worldwide. Because all accessions of the cultivated tomato are susceptible to these viruses, wild tomato species have become a valuable resource of resistance genes. QTL controlling resistance to TYLCV and other begomoviruses (Ty loci) were introgressed from several wild tomato species and mapped to the tomato genome. Additionally, a non-isogenic F₁diallel study demonstrated that several of these resistance sou
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