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Kamikura, Darren M. "Structurefunction analysis of the met receptor oncoprotein, Tpr-met." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37575.
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The Met protooncogene encodes a receptor tyrosine kinase that is deregulated by point mutation, and overexpression/amplification in a number of human tumours. The Met receptor is also oncogenically activated following genomic rearrangement which generates a cytoplasmic, constitutively activated fusion protein, Tpr-Met. In addition to autophosphorylation sites within the catalytic domain, the carboxy terminus of Tpr-Met/Met contains a single major site of autophosphorylation, tyrosine 489. This tyrosine residue represents a unique multisubstrate binding site, capable of binding numerous intracellular proteins, and is critical for the biological activities of both the Met receptor and Tpr-Met oncoprotein. Addition of the c-src myristoylation sequence to the amino terminus of the normally cytoplasmic Tpr-Met, localizes Tpr-Met to plasma membranes and enhances cellular transformation, in vitro invasion, and tumourigenicity. Furthermore, a membrane targetted Tpr-Met is localized to a similar subcellular compartment as the Met receptor, and alters the complement of signalling proteins required for efficient transformation. In this respect, a membrane localized Tpr-Met resembles oncogenic forms of the transmembrane Met receptor, and provides a model with which to study transformation by Met receptor oncoproteins. Significantly, membrane localization of Tpr-Met induces a phosphoinositide 3' kinase (PI3' K) dependent autocrine loop, involving the production of hyaluronic acid (HA), and post-translational modification of the cell surface receptor for HA, CD44. PI3'K activity and the HA/CD44 autocrine loop, are dependent on the multisubstrate binding site, tyrosine 489, and tyrosine residue 498, a residue with no previously described biochemical function. Although the exact mechanisms by which PI3'K regulates HA production are unclear, the induction of a HA/CD44 autocrine loop may represent a novel mechanism by which deregulated receptor tyrosine kinases increase their onco
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Kamikura, Darren M. "Structure/function analysis of the Met receptor oncoprotein, Tpr-Met." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0019/NQ55343.pdf.
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Ozgur, Ozge. "An Analysis Of Rail Transit Investments In Turkey: Are The Expectations Met?" Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12611244/index.pdf.
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Rail transit investments require highest amount of investment costs of all modes and
considering the high cost involved, it is particularly important that their performance justifies
this high cost and that expectations from these investments are met. Therefore, in the world,
it has become an important field of research to study the performances of rail systems in
order to assess whether these expectations are met.
In Turkey, there is a growing interest in constructing rail transit systems in the cities.
However, there has been limited number of studies on the performance of these investments.
There are researches on individual systemsyet, there has not been a comprehensive, systematic and comparative evaluation of the rail transit experience of Turkish cities. It is not clear with what expectations these systems are built or whether these expectations are met. There seems to be an urgent need to study these rail investments, with a particular focus on their planning, investment objectives and outcomes. This thesis analyzes the expectations from the rail transit systems in Turkey and answers the question whether these expectations are met. In order to understand the objectives under the planning and decision making processes in the implementation of Turkish rapid rail transport investments, a sample group was selected among the cities currently operating rail transit systems: &
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stanbul, Ankara, &
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zmir and Bursa. The study sets the objectives in planning and implementing rail transit systems drawn by the answers in the semi-structured interviews. It compares the expectations with the actual outcomes. As the primary indicators of performance, cost and ridership forecast and outcome data are also collected and considered in the comparison. It is found that the main success in all case study cities was the increase in public transport usage after the opening of the rail transit systems. On the other hand, systems performed rather poor in terms of other expectations, such as attaining ridership forecasts, being built within budget, creating an integrated public transport system, traffic reduction, air pollution reduction, improvement of city image, etc. Hence there is a gap between expectations and outcomes.
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Hanson, Todd T. "An analysis of Other Transactions : have Other Transactions met the intent of Congress? /." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2005. http://library.nps.navy.mil/uhtbin/hyperion/05Jun%5FHanson.pdf.
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Thesis (M.S. in Contract Management)--Naval Postgraduate School, June 2005.Thesis Advisor(s): Richard B. Doyle, E. Cory Yoder. Includes bibliographical references (p. 127-130). Also available online.
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Carter, David E. "A Meta-Analysis of Early Life Influences on Behavior." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342728891.
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林志立 and Chi-lap Lam. "Analysis of inventory systems with demands met either from inventory or by special deliveries." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B3120868X.
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Lam, Chi-lap. "Analysis of inventory systems with demands met either from inventory or by special deliveries /." [Hong Kong] : University of Hong Kong, 1988. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12359907.
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Eppanapelli, Lavan Kumar. "Investigation of wind potential variation at three measurement sites based on atmospheric stability and power production." Thesis, KTH, Kraft- och värmeteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-136935.
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As tapping energy from wind expands rapidly worldwide, it is a common procedure to locate a practicable site to extract energy from abundant wind flow by building wind farms. Comprehensive understanding of wind resource at a site is important to perform the main activities say, wind flow modeling, wind turbines micro siting, annual energy yield calculation and cost of energy estimation. Wind measuring campaigns involve using of measuring instruments such as meteorological tower instrumented with anemometers, wind vanes and temperature sensors; remote sensing devices such as SoDAR, LiDAR. These meteorological devices provide detailed information on wind behavior with respect to the height, time and temperature. These systems were proven in providing promising wind measurements even though they are susceptible to certain weather conditions. The study progressed by focusing on the wind behavior at three locations to investigate the possible factors that varies the wind character. A location with one met mast and two AQ500 SoDAR systems was considered for this project where one AQ500 is 800m away and other AQ500 is 5515m away from the point of Met mast. The location is contemplated as a decent approach to the spatial analysis of the wind resource as there is a large scope to analyze the wind character between two nearby sites and two faraway sites. Monostatic 3-beam SoDAR systems from AQ System, Sweden and 100m meteorological tower with instruments are used in this project work for collecting the wind data. One-year worth of wind data at standard 10min intervals has been collected from the three systems. This report outlines the theoretical description of project location, AQ500 SoDAR and Met mast. A detailed explanation of the data quality control and filtering methods are discussed along with respective reasons. The conclusion is drawn after performing the statistical analysis between wind speed and other parameters such as turbulent intensity, wind direction, thermal stability and temperature. Mat lab is used for computing and analyzing the wind data from three systems.
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Fonseca, Humberto Barroso da. "Anthropometric profile analysis, lifestyle and mammography findings in 76 women met in education and cancer studies group (GEEON)." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13450.
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O CÃncer de Mama à a neoplasia que mais acomete mulheres em todo o mundo, a OrganizaÃÃo Mundial de SaÃde estima que, por ano, ocorram mais de 1,67 milhÃes de casos novos de cÃncer de mama em todo o mundo. à a primeira neoplasia que mais mata nos paÃses em desenvolvimento, como à o caso do Brasil. Os principais fatores de risco para o CÃncer de Mama sÃo: envelhecimento, fatores relacionados à vida reprodutiva da mulher, histÃria familiar de cÃncer de mama, consumo de Ãlcool, excesso de peso, sedentarismo, exposiÃÃo à radiaÃÃo ionizante e alta densidade do tecido mamÃrio. O Ãndice de Massa Corporal (IMC) e amplamente usado para mensurar a obesidade. Nas Ãltimas dÃcadas diversos estudos sobre estes determinantes sÃo considerados de suma importÃncia para que se possa intervir preventivamente, reduzindo a chance de ocorrÃncia da doenÃa. Foram avaliadas 114 mulheres submetidas à mamografia no GEEON, destas 76 atenderam aos critÃrios de inclusÃo. As mulheres eram submetidas à mamografia e posteriormente a uma entrevista e uma mensuraÃÃo do peso, altura, medida da circunferÃncia da cintura e do quadril. Os dados foram tratados atravÃs da anÃlise de variÃncia (ANOVA), divididos pelos resultados BI-RADS encontrados. Os resultados encontrados apresentaram valores p=0,054 para a relaÃÃo entre o IMC e os achados mamogrÃficos BI-RADS, 49% apresenta sobrepeso I e 21% do grupo apresenta sobrepeso II, nÃo foram detectados casos de obesidade mÃrbida. Os resultados da RelaÃÃo Cintura Quadril apresentaram que 37% apresentam risco alto e 26% risco muito alto. O estilo de vida das entrevistadas 45% apresenta uma dieta rica em gorduras e frituras e 38% se mostra insuficientes no consume de frutas e verduras, 71% nÃo praticam atividade fÃsica regular e nÃo conseguem equilibrar vida profissional com o lazer. Nas condiÃÃes que foi desenvolvido este trabalho pode-se concluir que nÃo existiu diferenÃa significativa entre os grupos BI-RADS e o IMC e o R C/Q e que o estilo de vida destas mulheres predispÃe o risco do surgimento de doenÃas.O CÃncer de Mama à a neoplasia que mais acomete mulheres em todo o mundo, a OrganizaÃÃo Mundial de SaÃde estima que, por ano, ocorram mais de 1,67 milhÃes de casos novos de cÃncer de mama em todo o mundo. à a primeira neoplasia que mais mata nos paÃses em desenvolvimento, como à o caso do Brasil. Os principais fatores de risco para o CÃncer de Mama sÃo: envelhecimento, fatores relacionados à vida reprodutiva da mulher, histÃria familiar de cÃncer de mama, consumo de Ãlcool, excesso de peso, sedentarismo, exposiÃÃo à radiaÃÃo ionizante e alta densidade do tecido mamÃrio. O Ãndice de Massa Corporal (IMC) e amplamente usado para mensurar a obesidade. Nas Ãltimas dÃcadas diversos estudos sobre estes determinantes sÃo considerados de suma importÃncia para que se possa intervir preventivamente, reduzindo a chance de ocorrÃncia da doenÃa. Foram avaliadas 114 mulheres submetidas à mamografia no GEEON, destas 76 atenderam aos critÃrios de inclusÃo. As mulheres eram submetidas à mamografia e posteriormente a uma entrevista e uma mensuraÃÃo do peso, altura, medida da circunferÃncia da cintura e do quadril. Os dados foram tratados atravÃs da anÃlise de variÃncia (ANOVA), divididos pelos resultados BI-RADS encontrados. Os resultados encontrados apresentaram valores p=0,054 para a relaÃÃo entre o IMC e os achados mamogrÃficos BI-RADS, 49% apresenta sobrepeso I e 21% do grupo apresenta sobrepeso II, nÃo foram detectados casos de obesidade mÃrbida. Os resultados da RelaÃÃo Cintura Quadril apresentaram que 37% apresentam risco alto e 26% risco muito alto. O estilo de vida das entrevistadas 45% apresenta uma dieta rica em gorduras e frituras e 38% se mostra insuficientes no consume de frutas e verduras, 71% nÃo praticam atividade fÃsica regular e nÃo conseguem equilibrar vida profissional com o lazer. Nas condiÃÃes que foi desenvolvido este trabalho pode-se concluir que nÃo existiu diferenÃa significativa entre os grupos BI-RADS e o IMC e o R C/Q e que o estilo de vida destas mulheres predispÃe o risco do surgimento de doenÃas.
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Gebien, Darryl Jordan. "Loss of heterozygosity analysis of c-met and an adjacent locus, D7S95, in human non-small cell lung carcinoma." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27322.
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The c-met proto-oncogene encodes a tyrosine kinase receptor for hepatocyte growth factor/scatter factor. Losses of c-met alleles have been documented in human carcinomas. In breast carcinoma c-met has been suggested to be a potential inactivated tumour suppressor gene (TSG). In non-small cell lung carcinoma (NSCLC) a general reduction of c-met expression in squamous cell carcinomas (SQCCs), as well as overexpression in adenocarcinomas (ADCs) have been revealed. Furthermore, many SQCCs and ADCs had undetectable c-met mRNA and protein. These results prompted us to explore c-met allelic alterations in NSCLC. Our main goal was to address the possible involvement of inactivated c-met alleles in the development and progression of NSCLC. In this LOH analysis two polymorphic-sensitive probes corresponding to the c-met gene, p-metH and p-metD, were used to analyze normal and tumour DNA samples from patients with primary NSCLC. Of 110 cases examined with p-metH, 56 (50.9%) were informative and 4 (7.1%) exhibited LOH. Among 109 patients examined with p-metD, 28 (25.7%) were informative and 1 (3.6%) was LOH-positive. The combined LOH incidence for c-met was 7.4% (5/68 informative cases). Lastly, since a locus adjacent (distally) to c-met on chromosome 7, D7S95, was shown to exhibit a significant LOH frequency in gastric carcinoma (43.3%), we also sought to determine if loss of this locus was common in NSCLC. Of 104 patients examined at D7S95, 45 (43.3%) were informative and 1 (2.2%) exhibited LOH. These findings suggest, firstly, that c-met does not have a possible role as an inactivated TSG in the tumourigenesis of NSCLC nor is it closely linked to a putative TSG, and secondly, D7S95 does not contain a detectable inactivated TSG or a closely-mapping TSG in NSCLC.
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Gebien, Darryl Jordan. "Loss of heterozygosity analysis of c-met and an adjacent locus, D7S95, in human non-small cell lung carcinoma." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29697.pdf.
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Previdi, Sara. "HGF/C-MET in breast-cancer bone metastasis : characterization and imaging analysis to evaluate the efficacy of traget therapies." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551620.
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cancer exhibits a propensity to metastatize to bone, resulting in debilitating skeletal complications associated with significant morbidity and poor prognosis. The interactions between metastatic cells and bone are critical to the development and progression of bone metastases and their unravelling could lead to novel therapeutic approaches. This PhD thesis intended to investigate the contribution of the HGH/c-Met pathway to the pathogenesis of bone metastasis. An experimental breast cancer bone metastatic model were used, in combination with in vivo imaging techniques, to demonstrate the involvement of HGF/c-Met system in tumor-bone interaction contributing to bone metastatisation. Moreover, the efficacy of three therapeutic approaches able to interfere with the HGC/c-Met pathway has been investigated. Firstly, I demonstrated that NK4, an HGF antagonist, induces a delay in the progression of bone metastasis probably via its bifunctional properties to act as an HGF antagonist and an angiogenesis inhibitor. Secondly, the efficacy of strategies directed against c-Met receptor, including both a c-Met inhibitor, ARQ197, and a specific shRNA, has been evaluated. Dual c-Met inhibition induces a pronounced tumor growth suppression with concomitant marked decreases of lytic lesions and prolongation of survival. Finally, the effect of targeting PLCyl, one of the c-Met downstream effectors, has been explored. Surprisingly, PLCyl silencing by shRNA significantly accelerates the formation and progression of bone metastases. Overall, these findings highlighted the efficacy of HGF/c- Met inhibition in delaying the onset and progression of bone metastases and strongly suggested that targeting the HGF ligand or the c-Met receptor may have promising therapeutic value in the treatment of breast cancer bone metastases. Despite that, special attention should be paid to block PLCyl since its inhibition could potentiate the aggressive phenotype of breast cancer cells stimulating bone metastatic disease. Therefore, PLCyl should not be considered as a therapeutic candidate for the management of bone metastasis.
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Godinez, Detre. "The Wisconsin Card Sorting Task: An analysis of the construct validity, heritability, and association with the COMT Val(158)Met polymorphism." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3273679.
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Murat, Cahue de Bernardis. "Estudo molecular dos componentes da via de sinalização HGF/MET em insulinomas." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-03102013-110107/.
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Os insulinomas são os tumores neuroendócrinos pancreáticos funcionantes mais frequentes, entretanto, os aspectos moleculares envolvidos em sua tumorigênese precisam ser melhor esclarecidos. As características morfológicas e histoquímicas dos insulinomas não conseguem predizer completamente seu comportamento biológico, apenas o fenótipo invasivo local e a presença de metástase são as formas confiáveis do diagnóstico maligno. A presente investigação teve por objetivos analisar a expressão gênica por reação em cadeia da polimerase (PCR) em tempo real e a expressão protéica por imuno-histoquímica dos componentes da via de sinalização do fator de crescimento hepatocítico (HGF) e seu receptor (c-MET) em 27 amostras de insulinomas, sendo: 16 tumores benignos grau 1 (G1), seis tumores benignos grau 2 (G2), dois insulinomas malignos grau 3 (G3) e três metástases hepáticas. Além disso, realizou-se a pesquisa de mutações somáticas no gene MET. Observou-se (1) o aumento da expressão dos genes HGF, MET e ST14 (codificante para a matriptase) e a baixa expressão do gene HAI-1 (codificante para a protease inibidora tipo-kunitz do tipo 1) nos insulinomas malignos e metástases quando comparados aos insulinomas benignos G1; (2) uma correlação positiva entre a expressão do mRNA do gene MET e o gene ST14 e índice proliferativo Ki-67, bem como uma correlação inversa entre a expressão do mRNA do gene HAI-1 e os genes MET, HGF, ST14 e o índice mitótico; (3) uma correlação positiva entre a expressão do gene ST14 e a expressão do mRNA do gene HGF; (4) maior expressão protéica de c-MET nos insulinomas malignos G3 em relação aos insulinomas G1/G2 e (5) ausência de mutações nos éxons 2, 10, 14, 16, 17 e 19 do gene MET. Concluiu-se que os genes HGF, MET, ST14 e HAI-1 estão diferencialmente expressos entre insulinomas malignos e benignos, o que pode ter implicações diagnósticas e terapêuticasIn an attempt to better understand the molecular processes involved in the tumourigenesis of islet beta-cells, the present study evaluated the expression of genes belonging to the hepatocyte growth factor and its receptor (HGF/MET) system, namely, MET, HGF; HGFAC and ST14 (encode HGF activator and matriptase, respectively, two serine proteases that catalyze conversion of pro-HGF to active HGF); and SPINT1 and SPINT2 (encode serine peptidase inhibitors Kunitz type 1 and type 2, respectively, two potent inhibitors of HGF activator and of matriptase) in 27 sporadic insulinomas; 16 grade 1 (G1), six grade 2 (G2), two grade 3 (G3) and three hepatic metastases. Quantitative reverse-transcriptase polymerase chain reaction was employed to assess RNA expression of the target genes and immunohistochemical analysis was used to evaluate the expression of MET and SPINT1. Somatic mutations of MET gene were searched by direct sequencing of exons 2, 10, 14, 16, 17 and 19. Overexpression of MET was observed in grouped G3 insulinomas and metastases concomitantly with upregulation of the genes encoding HGF and matriptase and downregulation of SPINT1. Positive correlations were observed between MET RNA expression and Ki-67 proliferation index while a negative correlation was detected between SPINT1 expression and the mitotic index. No somatic mutations were found in MET gene. The final effect of the increased expression of HGF, its activator (matriptase) and its specific receptor (MET) together with a decreased expression of one potent inhibitor of matriptase (SPINT1) is probably a contribution to tumoural progression and malignancy in insulinomas
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Njiwa, Paule. "Comparaison du comportement tribologique des molécules de thiophosphates et de phosphates de zinc en tant qu'additifs anti-usure." Phd thesis, Ecole Centrale de Lyon, 2011. http://tel.archives-ouvertes.fr/tel-00750886.
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Grâce à ses propriétés d'antioxydant, d'anti-usure et éventuellement d'extrême pression le dithiophosphate de zinc (ZDDP) fait partie des additifs les plus utilisés dans les lubrifiants pour moteurs thermiques. De nos jours, dans un souci de respect de l'environnement, de nouveaux lubrifiants possédant de bonnes performances en lubrification (frottement faible et usure limitée) sont développés en prenant compte des limitations d'utilisations actuelles du ZDDP. L'idée étant de réduire dans ceux-ci les teneurs en phosphore et soufre (Normes euros VI), éléments essentiels du ZDDP qui endommagent les pots catalytiques. L'objectif de cette thèse est l'étude du comportement tribologique du phosphate de zinc di alkyl (ZP) en comparaison avec le ZDDP. La méthodologie expérimentale étudiée pour comprendre le mécanisme d'action de ces additifs, associe des essais de frottement à descaractérisations physico-chimiques des surfaces frottantes après essais.Cette comparaison a été effectuée en fonction de la température (25°C et 100°C), la vitesse de glissement (25, 50 et 100 mm/s) et la concentration en additif (200 et 600 ppm dephosphore). Les meilleures actions anti-usure sont obtenues avec le ZDDP pour une température de 100°C et une vitesse de glissement de 100 mm/s et le ZP pour une température de 25°C et une vitesse de glissement de 25 mm/s. Les analyses de surface XPS, AES, XANES et MET-EDX ont permis de mettre en évidence la présence d'un film protecteur constitué principalement de phosphate de zinc, ceci pour les deux additifs.Une synergie de comportement tribologique a été mise en évidence avec un lubrifiantconstitué de ZP (usure faible) et d'oléate d'urée (frottement faible). Des essais complémentaires sur un tribomètre dynamique ont permis d'étudier le niveau de frottement du tribofilm formé à partir du ZDDP. Le caractère visqueux du tribofilm de ZDDP a été mis en évidence.
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Faul, Dinelle. "Kindgesentreerde spelterapie en sandkasspelterapie met 'n kind met die Aspergersindroom / D Faul." Thesis, North-West University, 2013. http://hdl.handle.net/10394/10119.
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The purpose of this study was to research the therapeutic outcomes achieved by a five year-old boy with Asperger Syndrome (AS), by means of non-directive processes of child centred play therapy (CCP) and sand tray play therapy (STP). In this investigative-descriptive qualitative research design, a saturated, holistic, intrinsic single case study was used as research method. The therapeutic process, events and outcomes of a unique single case within the context of AS, non-directive play therapy and the interactional-pattern analysis (IPA), are described. This study was motivated by the fact that the researcher disposed of data for a unique single case study that could contribute meaningfully to the need for a research database that describes effective therapeutic interventions and outcomes with children with AS. From the perspective of Rogerian person-centred theory (RPT), the literature study focused on an integrated discussion of AS, CCP and STP by means of 17 interpersonal variables of the interactional-pattern analysis (IPA). The following data sources was investigated: interviews with parents and teachers; CCP-sessions of J recorded on video; photos of some of J’s STP-sessions and the therapists’ process notes. Triangulation was used to evaluate the various categories of therapeutic outcomes from different viewpoints and to give meaning to them. The conclusions indicated that this boy with AS had used the non-directive processes of CCP and STP to achieve various therapeutic outcomes in the areas of: imaginary play; dramatic play; social interaction with the therapist, parents, family, teachers, his peer group and with strangers; traumatic experiences during visits to the doctor and bath times; identification, expressing and regulating emotions; and minimising acting out behaviour. Therapeutic outcomes have been demonstrated in 8 IPA-variables, namely: empathy, defining of relationships, potential to evoke acceptance or rejection, sincere interest and congruent conduct, control, emotional distance, problem solving and aspects relating to the presenting problem. The conclusion was reached that the conduct of the boy with AS as well as his mother and the therapist, played a mutual role in achieving his therapeutic outcomes within the 17 IPA-variables. The unstructured process of the non-directive play (CCP and STP) was utilised by a young child with AS to achieve therapeutic outcomes that relate to his everyday existence. A final conclusion is that involving the boy’s mother in his therapy and utilising an adapted Filial play program, enabled the mother to make emotional contact with her son and to diminish conflict between them. Guidelines for therapists are suggested with regard to non-directive responding in therapeutic contexts as found in this study. Furthermore, the contribution of this research to Psychology as science and discipline, is presented. Limitations of this study are indicated and recommendations for further research are made.Thesis (Ph.D. (Psigologie))--North-West University, Vaal Triangle Campus, 2013
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Fridjonsson, Liselotte, Mathilda Brink, and Malin Brytting. "Hållbar Textil Produktutveckling : med växtfärgning." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-518.
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Författarna har haft ett samarbete med Panduro Hobby i samband med deras årliga miljökampanj. Syftet med examensarbetet har varit att med hjälp av befintliga produktutvecklingsprocesser och livscykelanalyser (LCA) ta fram en hållbar textil produkt med växtfärgning. Tanken var att konsumenter sedan själva skall kunna ta fram och växtfärga denna hållbara textilprodukt. Miljömedvetenhet och hållbarhet inom textilindustrin är ett aktuellt ämne. Trots det saknar dagens konsumenter förståelse för textilindustrins påverkan på miljön och har bristande kunskap om textila material för att kunna göra miljövänliga val ute i handeln. Både konsumenter och företag uttrycker att de gärna vill bidra till en mer miljövänlig textilindustri men att de saknar kännedom, resurser och verktyg för att göra det. Därför valde författarna av examensarbetet att undersöka hur en hållbar textil produkt kan tas fram med hjälp av livscykelanalyser, produktutvecklingsmetoden Product Ideas Tree (PIT) samt växtfärgning. Alla steg under produktutvecklingsprocessen valdes ur miljöhänsyn och efter de förutsättningar som krävs för att göra en så miljövänlig textil produkt som möjligt. Resultatet av undersökningen blev en växtfärgad tygkasse i 100 % lin. Efter framtagningen av produkten gjordes en livscykelanalys benämnd MET-matris för att analysera produktens miljöpåfrestning. Matrisen konstaterade att produkten inte har avsevärda miljöbrister. Med examensarbetet och den framtagna produkten vill författarna uppmuntra konsumenter och företag till att fortsätta visa engagemang och intresse för förändringar som gynnar miljön med förhoppningen om att få fler att agera mer hållbart.The authors have had a collaboration with Panduro Hobby in addition to their annual environmental sustainability campaign. The aim of the thesis has been to develop a sustainable textile product with natural dye using existing product development processes and Life Cycle Assessment (LCA). The idea was that consumers later on would be able to produce this sustainable textile product and dye it themselves. Environmental awareness and sustainability in the textile industry is a topical subject. Nevertheless many consumers lack sufficient knowledge of textile materials to make environmentally friendly choices in the commerce. Both consumers and businesses express that they would like to contribute to a more environmentally friendly textile industry, but that they lack the knowledge, resources and tools to do it. Therefore, the authors of the thesis chose to explore how a sustainable textile product may be produced with the help of Life Cycle Assessment and the product development method Product Ideas Tree (PIT). All steps in the product development process were carefully chosen with consideration to the environment and the circumstances required to make the textile product as sustainable as possible. The study resulted in the development of a canvas bag made out of 100% linen dyed it with natural dye. After the product development a Life Cycle Analysis, referred to as MET Matrix, was done to analyse the product's environmental strain. The matrix noted that the product does not have significant environmental burdens. With the thesis and the produced product the authors would like to encourage consumers and businesses to continue to show commitment and interest in changes that benefit the environment, with the hope of getting more people to act more sustainably.
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Starr, Kameron D. "Microfluidic Device for Phenotype-Dependent Cell Agility Differentiation and Corresponding Device Sensory Implementation." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1502896489271416.
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Jouanny, Emilie. "Étude de l'évolution microstructurale sous irradiation aux ions Ti2+ de deux alliages de titane : lien avec les propriétés mécaniques." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0071/document.
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Ce travail de thèse s’intéresse à l’évolution de la microstructure sous irradiation d’alliages de titane, en vue de leur potentielle utilisation dans le domaine du nucléaire. Une étude paramétrique (température, dose et flux d’irradiation) a donc été menée, à l’aide de simulations d’irradiations neutroniques par des irradiations aux ions (plateforme JANNuS – Saclay), sur les alliages T40 et TA6V, et de caractérisations microstructurales qualitatives et quantitatives post irradiation (MET, analyse d’image, SAT). Ainsi, différents défauts d’irradiation ont été identifiés. En particulier, la présence de boucles à composante dans l’alliage T40 et de précipités riches en vanadium dans l’alliage TA6V a clairement pu être mise en évidence dès la température de 300°C. La microstructure résultante est fortement dépendante des paramètres d’irradiation et de l’alliage de titane considéré. Un effet important de la température (entre 300°C et 430°C) a été noté sur les boucles de dislocations de type pour l’alliage T40 et sur les précipités pour l’alliage TA6V. Les doses et les flux considérés à 300°C ne modifient pas la distribution des défauts des deux alliages. A 430°C, l’augmentation de la dose modifie peu le paysage des boucles de dislocations de type pour l’alliage TA6V contrairement à l’alliage T40. Les précipités, quant à eux ne semblent pas affectés par l’augmentation de la dose. Une analyse des mécanismes mis en jeu est proposée. Enfin, des essais de nano-indentation ont permis une première description du lien microstructure / propriétés mécaniques. A 430°C, l'alliage T40 ne semble pas être impacté mécaniquement par l’évolution de la microstructure avec la dose d’irradiation contrairement à l'alliage TA6VThis PhD work deals with microstructural evolution of titanium alloys under irradiation, due to their potential use in the nuclear field. Parametric study (temperature, dose and irradiation flux) was conducted, using ion irradiations (JANNuS – Saclay platform) to simulate neutron irradiation damage. Two titanium alloys (CP Ti grade 2 and Ti-6Al-4V) were considered and qualitative and quantitative post irradiation microstructural characterizations were done (TEM, image analysis, APT). Thus, various irradiation defects were identified. In particular, presence of -component loops was highlighted in CP Ti grade 2 and vanadium-rich precipitates in Ti-6Al-4V from the temperature of 300°C. Resulting microstructure is hardly depending on irradiation parameters and considered titanium alloys. Important effect of temperature (between 300°C and 430°C) was noted on -type dislocation loops in CP Ti grade 2 and precipitates in Ti-6Al-4V. At 300°C, dose and flux have no effect on the defect distribution of the two titanium alloys. At 430°C, the increase of dose has a little consequence on the -type dislocation loops in Ti-6Al-4V, contrary to the ones observed in CP Ti grade 2. Precipitates, observed in Ti-6Al-4V, do not seem to be affected by the increase of the dose. Analysis of involved mechanisms is proposed. Finally, nano-indentation tests have allowed to get first description of the link between microstructure and mechanical properties. At 430°C, CP Ti grade 2 do not seem to be affected mechanically by the microstructural evolution with the irradiation dose, contrary to Ti-6Al-4V
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Dreyer, Lydia. "Narratiewe groepterapie met adolessente : die ontwikkeling van 'n alternatiewe voorkomingsintervensie." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/1337.
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Thesis (DPhil (Psychology))—University of Stellenbosch, 2006.This study has two purposes which are complementary: Firstly, an alternative prevention intervention was developed in order to introduce narrative group therapy as a therapeutical practice within preventative interventions in South Africa. Secondly, a training protocol was developed which can be used to train psychologists, counsellors, social workers, teachers and relevant persons to apply narrative group therapy as an alternative preventative intervention in their communities. In the context of this study, the personal stories of the adolescents who took part in this study reflect the problem stories of the Jamestown and Cloetesville community near Stellenbosch. After identifying 20 adolescents who experience problem stories with high-risk themes at two secondary schools in the respective communities, ten narrative group sessions were held, with social constructionism as philosophical approach. The training protocol was primarily of an experiential nature, consisting of 40 hours of training and 12 hours of supervision, with special focus on the personal stories of the four master’s degree psychology students who underwent training and facilitated the group therapy with the adolescents. For the purpose of this study qualitative research was done. During the development of the alternative preventative intervention, a qualitative description was given of the content of the personal stories of the adolescents within the interactional space of narrative group therapy and personal stories. The focus during this qualitative description was the following: • to establish whether the therapeutic process facilitated change, • to develop a new understanding of the therapeutic process by specifically focusing on applying narrative therapy in a group, and • to train and empower narrative-group-therapy facilitators to facilitate the narrative- group-therapy process. In this study two narrative-analytical research methods were used. Firstly, a qualitative narrative-analysis method was used to evaluate the psychotherapeutical transcripts. A part of these sessions was dedicated to this purpose and is presented in transcribed format. Secondly, the content-analysis method was applied: session data was examined, categories of the adolescents’ and students’ narratives were defined and thematic statements were extracted from the text, classified and sorted into categories or groups. This study provides supportive evidence that narrative group therapy as an alternative preventative intervention can be introduced as a therapeutic practice in South Africa. In addition, an effective training protocol was developed which can be used to train psychologists, counsellors, social workers, teachers and other relevant individuals to use narrative group therapy as an alternative preventative intervention in their communities.
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Meziani, Smaïl. "Influence du procédé de congélation sur les levures et les propriétés techno-fonctionnelles des pâtes sucrées (type Kougelhopf)." Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL089N/document.
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Les pâtes surgelées sont relativement stables et peuvent être fabriquées à l’échelle industrielle, distribuées et cuites à la demande au moment de la vente ou de la consommation (point chaud). La congélation des pâtes sucrées induit une baisse de volume et une augmentation du temps de fermentation, ces conséquences sont dues à deux facteurs : la baisse de la production de CO2 (viabilité des levures) et la faible capacité de rétention de gaz du réseau gluténique. La perte de la qualité des pâtes congelées est accélérée durant le stockage. Cette thèse porte sur l’étude de l’effet de la congélation et de la conservation sur les levures et les propriétés techno-fonctionnelles des pâtes sucrées type Kougelhopf. Ce travail vise à l’étude de l’impact de la vitesse de congélation sur les propriétés microbiologiques, rhéologiques, structurales et sensorielles de ces pâtes. Elles ont été congelées à différentes températures (-20 °C, -30 °C, -40 °C et une immersion dans l'azote liquide) puis conservées à -40 °C pendant 9 semaines. Les principaux résultats de cette étude ont permis de mettre en évidence le rôle de la vitesse de congélation et de la durée de conservation sur les propriétés intrinsèques des pâtes sucrées surgelées. Il en découle que l’activité fermentaire et l’intégrité du réseau du gluten sont tributaire de la vitesse de congélation. En effet, cette dernière contrôle la taille et la localisation des cristaux de glace d’où la recherche d’un compromis entre une vitesse de congélation ni trop rapide pour diminuer la viabilité des levures ni trop lente pour former de gros cristaux pouvant perforer le réseau de gluten de la pâte. Ce travail a démontré que le surdosage de levure reste valable uniquement pour les pâtes sucrées surgelées destinées à être conservées au-delà de 4 semaines. Ce surdosage améliore ainsi la qualité globale du Kougelhopf en compensant la perte de l'activité des levures pendant la congélation et le stockageThe frozen doughs are relatively stable and can be manufactured on an industrial scale, distributed and baked on demand at the point of sale or consumption (Bake-off). Freezing sweet dough induces a decrease in specific volume and an increase in fermentation time, these effects are due to two factors: lower production of CO2 (yeast viability) and losing capacity to retain gas (gluten network integrity). The loss of quality of frozen dough is accelerated during storage. This study focuses on the freezing and frozen storage effects on Kougelhopf sweet doughs. The aim of this work is to study the impact of freezing rate on microbiological, rheological, structural, and sensory properties of sweet doughs. The sweet doughs were frozen at different temperatures (-20°C, -30°C, -40°C and an immersion in liquid nitrogen) and stored at -40°C for 9 weeks. The main results obtained showed an impact of freezing rate and frozen storage duration on the frozen doughs intrinsic properties. This study shown the dependence of fermentation activity and integrity of the gluten network with freezing rate, which controls size and location of ice crystals resulting in research of a compromise between freezing rate nor too fast to reduce yeast viability, nor too slow to form large ice crystals that could perforate gluten network. Added the yeast amount is necessary only for frozen sweet doughs to be stored beyond 4 weeks, which improves the overall quality of Kougelhopf by compensating for yeast activity decrease during freezing and frozen storage
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Bam, Isabel M. S. "'N Ondersoekende kwalitatiewe studie na die siektenarratiewe van individue met VIGS-demensiekompleks." Diss., Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-02092005-091416.
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Luwes, Nicolaas Johannes. "Massabepaling van bewegende voorwerpe op 'n vervoerband met behulp van DSP-tegnieke." Thesis, Bloemfontein : Central University of Technology, Free State, 2004. http://hdl.handle.net/11462/56.
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Thesis(M. Tech.) - Central University of Technology, Free State, 2004Growing markets leads to an increase in production. In these modern industries, weight measurement is of high priority. Weight measurement instrumentation is used for quality control, as well as for effective process control. Ineffective instrumentation with inaccurate data will influence the production process and profit margins negatively. Experimental data is gathered from an angled load cell, placed as a crossover between two conveyer belts. A weight measurement instrument with the ability to acquire accurate measurement of individual, moving parts is produced with the aid of DSP techniques. This was accomplished by analyzing the frequency spectrum for the undesirable signals with the use of Wavelets transformations (WT) and Fourier transformations (FT). After these undesired signals were identified a digital filter was designed to remove the undesired signals. Repetition of performance is achieved by the automatic zeroing of the instrument after every individual measurement. This weight measurement instrumentation also has the ability to store data consisting of the amount of objects and their individual weights. This instrument can also determine the material of which an object is made of. This is done by calculating the friction coefficient. This function has the ability to effectively identify between iron and rubber components irrespective of their mass or area.
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Coetzee, D. B. (Dirk Badenhorst). "Die ontleding van 39 maatskappye se kontantvloei situasie oor tyd met behulp van kontantvloeistate." Thesis, Stellenbosch : Stellenbosch University, 1997. http://hdl.handle.net/10019.1/55491.
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Thesis (MBA)--Stellenbosch University, 1997.ENGLISH ABSTRACT: In this study it is attempted to determine whether delisting of companies on the Johannesburg Stock Exchange is preceded by certain cash flow patterns. Information was collected by summarising the Source and Application of Funds statements and Cash Flow statements of companies into a spreadsheet model. The cash flows of companies were then presented graphically over time with the intent to derive possible patterns. It was also attempted to assess the impact of depreciation on the cash flow situation, as well as the possible reasons for share Issues. Although the sample may be too small for definite conclusions, it seems as if certain cash flow patterns preceded delisting and that share issues are related to investing activities. Depreciation does not seem to have a substantial effect on the cash flow situation.
AFRIKAANSE OPSOMMING: In hierdie studie word daar gepoog om vas te steI of denotering van maatskappye op die Johannesburgse Effektebeurs voorafgegaan word deur sekere kontantvloei patrone. Inligting is versarneI deur maatskappye se Bron en Aanwending van Fondse state en Kontantvloeistate in 'n sigbladmodeI saarn te vat. Die kontantvloeie van maatskappye is dan grafies voorgesteI oor tyd ten einde moontlike patrone af te lei. Daar is ook gepoog om die impak van waardevermindering op die kontantvloei situasie te bepaaI, asook die moontlike redes vir aandeeluitgifte. AlhoeweI die monster moontlik te klein is vir definitiewe afleidings wil dit tog voorkom of sekere kontantvloei patrone denotering voorafgaan en dat aandeeluitgifte verband hou met investeringsaktiwiteite. Dit blyk dat waardevermindering nie 'n wesenlike rol in die kontantvloei situasie speel nie.
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Oh, Jae-Ho. "Etude structurale de la graphitation naturelle : exemples de bassins sud-coreens." Orléans, 1987. http://www.theses.fr/1987ORLE2043.
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On etudie la formation du graphite naturel. On compare les carbones issus de series nturelles soumises a un metamorphisme croissant a des carbones traites exprimentalement. Leur texture et leur micro-structure sont analysees par microscopie electronique par transmission, par microspectrometrie raman et diffraction rx. La graphitation des carbones issus de vegetaux superieurs est comparable a la graphitation sous pression des carbones vitreux. Les materiaux d'origine algaire sont comparables aux carbones issus de la pyrolyse experimentale sous pression des parois d'algues
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Lisboa, Márcio Vieira. "Laserterapia e farmacoterapia com relaxante muscular em masseter de ratos submetidos a desgaste oclusal: análise comparativa através do met e espectroscopia de raman." Programa de Pós- Graduação em Odontologia da UFBA, 2008. http://www.repositorio.ufba.br/ri/handle/ri/10501.
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A ação da oclusão sobre as Disfunções Temporomandibulares (DTM) ainda é indefinida, principalmente em relação à função muscular. Por isso, terapêuticas não invasivas e reversíveis, como o laser, são terapias válidas e aceitas na literatura. O objetivo desse estudo é avaliar possíveis alterações no músculo masseter de ratos submetidos à laserterapia após alteração oclusal. Foram utilizados 40 ratos Wistar, divididos aleatoriamente em quatro grupos, sendo 10 para o grupo controle, 10 para o grupo Desgaste Oclusal (DE), 10 para o grupo DE + Laserterapia (l830nm) com dose de 4J/cm2 e 10 para o grupo DE + Relaxante Muscular (Dantrolene 2,5 mg/Kg). As cúspides superiores e inferiores dos molares esquerdos dos ratos foram desgastadas com broca diamantada sob refrigeração de solução salina. Os ratos do grupo controle não tiveram desgaste oclusal. Metade dos ratos de cada grupo foi sacrificada aos 14 dias e a outra metade 30 dias após o desgaste oclusal. Após o período experimental, o músculo masseter foi removido do lado ipsilateral ao desgaste oclusal em cada animal e, então, processado para microscopia de luz, microscopia eletrônica de transmissão e mensuração da intensidade Raman para o fosfato de cálcio precipitado nas fibras musculares. Não houve diferença entre os grupos na análise por microscopia de luz, apenas a microscopia de transmissão foi capaz de detectar injúria intracelular nas fibras do grupo DE: mitocôndrias edemaciadas, com perda de cristas e matriz clara; hipercontração da banda I; miofibrilas desorganizadas e presença de numerosos vacúolos. Nos grupos tratados com laser e farmacoterapia, a ultra-morfologia apresentou-se semelhante a do grupo controle. Quanto ao fosfato de cálcio, houve diminuição da intensidade Raman no grupo laser 30 dias. De acordo com os resultados, houve alterações nas fibras musculares do masseter ipsilateral ao desgaste oclusal unilateral em ratos Wistar, no entanto, a laserterapia e a farmacoterapia contribuíram moderadamente como forma de tratamento para o masseter nas condições estudadas.
Salvador
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Southerland, Jodi L., Taylor M. Dula, W. T. Dalton, Karen E. Schetzina, and Deborah L. Slawson. "The National School Lunch Program in Rural Appalachian Tennessee – or Why Implementation of the Healthy, Hunger Free Kids Act of 2010 was Met with Challenges: A Brief Report." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5115.
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Purpose: The purpose of this study was to investigate challenges faced by high schools in rural Appalachia in implementing the Healthy, Hunger Free Kids Act of 2010 (HHFKA). Methodology: We used qualitative, secondary analysis to analyze a collection of thirteen focus groups and 22 interviews conducted in 2013-14 among parents, teachers, and high school students in six counties in rural Appalachian Tennessee (n=98). Results: Five basic themes were identified during the thematic analysis: poor food quality prior to implementation of the HHFKA school nutrition reforms; students’ preference for low-nutrient energy-dense foods; low acceptance of healthier options after implementation of the HHFKA school nutrition reforms; HHFKA school nutrition reforms not tailored to unique needs of under-resourced communities; and students opting out of the National School Lunch Program after implementation of the HHFKA school nutrition reforms. Rural communities face multiple and intersecting challenges in implementing the HHFKA school nutrition reforms. Conclusion: As a result, schools in rural Appalachia may be less likely to derive benefits from these reforms. The ability of rural schools to take advantage of school nutrition reforms to improve student health may depend largely on factors unique to each community or school.
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Karathanou, Argyro. "Image processing for on-line analysis of electron microscope images : automatic Recognition of Reconstituted Membranes." Phd thesis, Université de Haute Alsace - Mulhouse, 2009. http://tel.archives-ouvertes.fr/tel-00559800.
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The image analysis techniques presented in the présent thesis have been developed as part of a European projeet dedicated to the development of an automatic membrane protein crystallization pipeline. A large number of samples is simultaneously produced and assessed by transmission electron microscope (TEM) screening. Automating this fast step implicates an on-fine analysis of acquired images to assure the microscope control by selecting the regions to be observed at high magnification and identify the components for specimen characterization.The observation of the sample at medium magnification provides the information that is essential to characterize the success of the 2D crystallization. The resulting objects, and especially the artificial membranes, are identifiable at this scale. These latter present only a few characteristic signatures, appearing in an extremely noisy context with gray-level fluctuations. Moreover they are practically transparent to electrons yielding low contrast. This thesis presents an ensemble of image processing techniques to analyze medium magnification images (5-15 nm/pixel). The original contribution of this work lies in: i) a statistical evaluation of contours by measuring the correlation between gray-levels of neighbouring pixels to the contour and a gradient signal for over-segmentation reduction, ii) the recognition of foreground entities of the image and iii) an initial study for their classification. This chain has been already tested on-line on a prototype and is currently evaluated.
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Issa, Inas. "In situ TEM nanocompression and mechanical analysis of ceramic nanoparticles." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEI008/document.
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Dans cette étude, nous proposons d’utiliser la compression in situ dans le MET afin de caractériser les propriétés mécaniques de nanoparticules céramiques dont la taille caractéristique est de l’ordre de quelques dizaines de nanomètres. Nous appliquerons cette méthode à des nanocubes monocristallins de MgO, une céramique modèle dont la plasticité est bien connue dans le matériau massif. Les essais de nanocompression montrent que les nanocubes de MgO se déforment de façon homogène jusqu’à de grandes déformations (>50%) sans fissure apparente. L’analyse des résultats est assistée par des méthodes de corrélation d’images numériques et simulations de type dynamique moléculaire. Le mécanisme de déformation et l'effet de taille sur la limite élastique sont identifiés. Dans une deuxième partie de la thèse, nous présentons une étude sur des nanoparticules d’alumine de transition compactée en CED (Cellule à Enclumes en Diamant) à température ambiante, sous plusieurs pressions (5 GPa, 15 GPa et 20 GPa). Des lames minces préparées par FIB ont été étudiées en MET. Des images HRTEM montrent une texture cristallographique qui devient plus importante à des pressions plus élevées. Une orientation cristallographique préférentielle est observée, avec les plans {220} de la phase gamma de l’alumine la plupart du temps parallèles à la surface de contact avec une particule voisine. Ce comportement mécanique est cohérent avec un système de glissement, connu pour les structures spinelles. Une corrélation de ce comportement avec les tests in situ MET réalisés sur des nanoparticules similaires, par Emilie Calvié lors de sa thèse, est présentée. Enfin, des clichés de diffraction de type Debye Scherrer sont réalisés sur ces lames minces de nanoparticules d’alumine de transition compactées en CED à différentes pressions. L’analyse quantitative de ces clichés montre une transformation de phase de ces nanoparticules d’alumine de phase gamma en phase delta, de manière croissante avec la pressionIn this study, we propose an innovative mechanical observation protocol of ceramics nanoparticles in the 100nm size range. This Protocol consists of in situ TEM nanocompression tests of isolated nanoparticles. Load–real displacements curves, obtained by Digital Image Correlation, are analyzed and these analyses are correlated with Molecular Dynamics simulations. By this protocol a constitutive law with its mechanical parameters (Young modulus, Yield stress...) of the studied material at the nano-scale can be obtained. In situ TEM nano-compression tests on magnesium oxide nanocubes are performed. Magnesium oxide is a model material and its plasticity is very well known at bulk. The MgO nanocubes show large plastic deformation, more than 50% of plastic strain without any fracture. The TEM results are correlated to MD simulations and the deformation mechanism can be identified.The size effect and the electron beam effect on the yield strength are investigated. In a second part of the dissertation, we present a study on transition alumina nanoparticles compacted in a Diamond Anvil Cell at different uniaxial pressures. Thin Foils of these compacted nanoparticles are prepared by FIB for HRTEM Observations. Their analysis reveals the plastic deformation of the nanoparticles. The crystallographic texture observed inthese compacted nanoparticles in DAC shows a preferred orientation of the {110} lattice planes, orientated perpendicular to the compression direction. This is compatible with the slip system. This argument was reinforced with a preferred orientation of slip bands observed during in situ TEM nano-compression tests. Moreover, electron diffraction patterns (Debye Scherrer) analysis on these compacted transition alumina nanoparticles reveals the decrease of the presence of gamma-alumina and the increase of delta-alumina with increasing pressure. This reveals the phase transformation with increasing pressure from gamma to delta* alumina
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Rinckenbach, Thierry. "Diagenese minerale des sediments petroliferes du delta fossile de la mahakam (indonesie) : evolution mineralogique et isotopique des composants argileux et histoire thermique." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13117.
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On etudie la diagenese des sediments deltaiques deposes sur plus de 4000m d'epaisseur du miocene inferieur a l'holocene a l'emplacement du delta actuel de la mahakam. On aborde les phenomenes de cimentation, de dissolution avec formation de porosite secondaire et de neoformations de kaolinite et illite a l'aide de la diffraction rx, de la microscopie electronique a balayage et a transmission, de la geochimie isotopique. On analyse les mecanismes d'illitisation ainsi que la formation de l'interstratifie illit nonesmectite en fonction de l'evolution thermique de la region
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Lo, Cheng-Tai, and 羅誠泰. "Cloning and functional analysis of DNA methyltransferase (MET) promoter of Phalaenopsis." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/16409719414563298901.
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碩士國立屏東科技大學
生物科技研究所
96
The purpose of this study was to clone the upstream sequence of DNA methyltransferase of Phalaenopsis and analyze the methylation pattern of genomic DNA in Phalaenopsis Little Mary mutant and wild-type. The upstream sequence of DNA methyltransferase obtained was 2,195 bp long, including 1,378 bp promoter and 817 bp 5`UTR. Sequence analysis of the PhMET promoter and 5`UTR reveals light and phytohormones response-related cis-acting elements and microRNA binding sites. There was no difference of methylation pattern genomic DNA between mutant and wild type in Phalaenopsis according to Southern blot analysis. RT-PCR analysis showed that PhMET was preferentially expressed in flower buds and weaker in fully-open flower in Doritaenopsis Sogo Vivien peloric mutant showed similar expression pattern but with lower level than the wild-type. To understand the role of PhMET in plant growth and development, sense, antisense and promoter in vector has been constructed , and transformed into tobacco and PLB of Phalaenopsis by Agrobacterium infection and particle bombardment. PCR and GUS analysis indicated the insersion of sense, antisense and promoter of PhMET in transgenic tobacco plants and Phalaenopsis PLB.
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Kuo, Chia-Chen, and 郭家禎. "The analysis of fof2 numerical mapping between GPS/MET and IRI model." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/c329ty.
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碩士國立中央大學
太空科學研究所
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Radio occultation technique of the Global Positioning System(GPS) has been applied to obtain vertical profile of electron density in the Ionosphere. Global Position System/Meteorology (GPS/MET) uses a satellite in low Earth orbit(LEO) to receive the phase signals of GPS radio wave affected by ionosphere while propagating through it. By using Abel integral transform under the assumption of spherical symmetry, we caculated more than forty thousands of vertical profiles of the ionospheric electron density from April 1995 to Feb 1997. And the retrieved foF2 values have been used to produce numerical maps. In this study, we choose our coordinate functions as a particular set of the functions which are linear combinations of surface spherical harmonics and are divided into three groups according to different orders from 0 to2. And the derived numerical maps will be compared with the original IRI maps.
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Lyu, Jhe-Fu, and 呂哲甫. "An Analysis of Environmental Non-Profit Organizational Change: The case of TEAN and MET." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/69380318192678560315.
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碩士世新大學
行政管理學研究所(含博、碩專班)
101
The purposes of the research are to examine the reasons for and the process of the merging of two environmental NGOs in Taiwan. While researches focusing on public and private sector organizational change have been abundant, few previous literatures concerning organizational change dealt with the way in which the merging of NGO is in progress, the strategies utilized to overcome the resistance it might ensue. Analysis of this thesis is made possible with the help of 9 former and incumbent members in terms of a series of semi-structured in-depth interviews with both Taiwan Environmental Action Network (TEAN) and Mercy on the Earth, Taiwan (MET) in Taiwan. What has been achieved can be summarized as following: 1. The continuity of concerned issues can be crucial for facilitating the process of Non-profit organization merging. 2. The commitment and engagement for causes of NGO and prospect for better development revealed by the members have been conducive to being no obvious resistance from both organizational and individual levels. 3. The nature of NGOs, either in the form of foundations or association, makes differences, since the former giving emphasis on “person” and the latter on “property.” It is the “property threshold” issue that complicated problems of the merging of two foundation based NGOs.
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Bellander, Ylva. "Återanvändning av sulfidförande berg : Aktuellt kunskapsläge, statistisk analys och biotillgänglighetsmodellering." Thesis, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-444793.
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Sulfidförande berg förekommer på många platser i Sveriges berggrund. När sulfidförande berg losshålls frigörs nya ytor som utsätts för kontakt med syre och vatten, vilket oxiderar sulfidmineralen och berget vittrar. Vittringsprodukten kallas surt lakvatten. Syftet med arbetet har varit att undersöka hur det sura lakvattnet påverkar den omgivande miljön, och hur spridning av det kan förhindras, samt vilka teoretiska möjligheter och risker det finns för användning av sulfidförande berg i infrastrukturprojekt. När lakvattnet kommer i kontakt med omkringliggande vattendrag orsakar det försurning och förhöjda metallhalter. Det kan också orsaka geotekniska skador. För att på ett säkert sätt kunna återanvända bergmaterialet bör provtagning och provanalys utföras enligt representativa metoder och bedömning av omgivningens förutsättningar ske. De metoder som idag används är i stor grad utvecklade för gruvnäringen och behöver därför anpassas. Om materialet bedöms lämpligt för återanvändning eller om sulfidbärande bergmaterial oavsiktligt använts finns en mängd metoder för att minska negativ påverkan på omgivningen. Mest effektivt är förhindrande av bildning av lakvatten genom övertäckning eller mikroinkapsling. Det finns även metoder för att förhindra spridning av surt lakvatten, såsom kalkning eller olika typer av barriärer eller dräneringsbäddar. För att det losshållna berget ska kunna återanvändas behöver hänsyn tas till en mängd olika lagar och regler. Inom ramen på projektet utfördes en fallstudie av ett område där sulfidförande berg losshållits och oavsiktligt använts som fyllnadsmaterial i lokala vägar. Detta har lett till att vattendraget som rinner genom området kraftigt förorenats med metaller och på vissa platser har mycket låga pH-värden. Sex metaller (Cd, Co, Cu, Ni, Pb and Zn) och sex andra parametrar (pH, Fe, fosfat, nitrat, sulfat och DOC) valdes ut för korrelationsanalys mellan metallerna och parametrarna med Kendall's Tau i fyra olika provpunkter. Statistiskt säkerställda korrelationer förekom mellan samtliga metaller och parametrar, men inte i alla punkter. Korrelationerna med pH och DOC var starkast, men även korrelationer med järn, fosfat och sulfat förekom enligt förväntan. Korrelationer med nitrat förekom med samtliga metaller men med oregelbundenhet och utan mönster. Biotillgänglighetsmodellering med verktyget bio-met utfördes för Cu, Ni, Pb och Zn. Biotillgängligheten var starkast relaterad till DOC-halten, men även samband med pH kunde statistiskt säkerställas. Ni och Zn var de metaller med högst biotillgänglighet. I vissa fall översteg den biotillgängliga koncentrationen HC5, gränsvärdet för skydd av 95 % av organismerna i vattendraget. I flera av punkterna över- eller underskred pH och kalciumhalten modellens godkända intervall. En utveckling av modellen för inkludering av fler förutsättningar och metaller är därför något att eftersträva.Sulfide-bering rock is found in multiple places in Swedish bedrock. When blasted, new surfaces is exposed and weathering occurs. This has the consequence that Acid Rock Drainage (ARD), water with low pH and high concentrations of heavy metals is spread to local watercourses, the environment becomes toxic. The aim of this project was to investigate theoretical possibilities and risks with recycling of sulfide-bering rock in infrastructure projects, as well as to examine how ARD affects the surrounding environment and how spreading of ARD can be prevented. To safely recycle the rock, it needs to be sampled and analysed by proper methods and the conditions of the sorrounding environment evaluated. Methods for applying this in infrastructure projects is currently being developed. If used, there is multiple methods to prevent or mitigate the spreading of ARD. The most effective way is to prevent its forming by covering or microencapsling, but prevention of spreading can also be dealt with by liming or drainage beds. A case study was made of an area affected by ARD. Correlation analysis with Kendall's tau was conducted between six metals (Cd, Co, Cu, Ni, Pb and Zn) and six other parameters (pH, Fe, phosphate, nitrate, sulphate and DOC). The correlations between the metals and pH as well as DOC was the stongest. It was difficult to find a pattern in the correlations with nitrate. Bioavailability modelling with the Biotic Ligand model bio-met was also made. Ni and Zn hade the highest bioavailable concentrations and exceeded the limit for protection of 95 % of species in one (Zn) or two (Ni) measuring stations. Expanded models for bioavailability is needed, since they have narrow boundaries for water chemistry conditions and only exist for few metals.
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"Cityscapes, Climate, and Mental Health: Prioritizing Thermal and Mental Wellbeing in the Design of Cities." Doctoral diss., 2020. http://hdl.handle.net/2286/R.I.62987.
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abstract: Urban climate conditions are the physical manifestation of formal and informal social forces of design, policy, and urban management. The urban design community (e.g. planners, architects, urban designers, landscape architects, engineers) impacts urban development through influential built projects and design discourse. Their decisions create urban landscapes that impact physiological and mental health for people that live in and around them. Therefore, to understand possible opportunities for decision-making to support healthier urban environments and communities, this dissertation examines the role of neighborhood design on the thermal environment and the effect the thermal environment has on mental health. In situ data collection and numerical modeling are used to assess current and proposed urban design configurations in the Edison Eastlake public housing community in central Phoenix for their efficacy in cooling the thermal environment. A distributed lagged non-linear model is used to investigate the relative risk of hospitalization for schizophrenia in Maricopa County based on atmospheric conditions. The dissertation incorporates both an assessment of design strategies for the cooling of the thermal environment and an analysis of the existing thermal environment’s relationship with mental health. By reframing the urban design of neighborhoods through the lens of urban climate, this research reinforces the importance of incorporating the community into the planning process and highlights some unintended outcomes of prioritizing the thermal environment in urban design.Dissertation/Thesis
Doctoral Dissertation Geography 2020
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Goldvasser, Pavel. "Identification of Novel Notch Target Genes in Breast Cancer." Thesis, 2011. http://hdl.handle.net/1807/30607.
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Notch signaling plays a key role in development, tissue homeostasis, and cancer. High expression levels of Notch signaling components are associated with aggressive disease and poor patient prognosis in breast cancer. Mesenchymal‐epithelial transition factor (MET) is a receptor tyrosine kinase with an established prognostic significance correlating with poor disease outcome in breast cancer patients as a result of high metastatic rate. We performed expression array analysis to identify candidate Notch target genes; we identified and validated MET as a target of NOTCH1 signaling in breast cancer. We found that NOTCH1 knockdown significantly reduces MET promoter activity, as well as expression levels of MET transcript and protein. The mechanism of NOTCH1 regulation of MET expression will be the focus of future work. To further identify candidate target genes of NOTCH1 signaling, we generated and validated a NOTCH1 antibody for use in chromatin immunoprecipitation experiments.
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Gouws, Johan. "Beheertegnieke vir stelsels met meer as een nie-lineariteit." Thesis, 2014. http://hdl.handle.net/10210/12215.
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De, Villiers Wessel van Zyl. "Bepaling van spoorelemente in uraanertse met behulp van X-straalfluoressensie-spektrometrie." Thesis, 2014. http://hdl.handle.net/10210/10064.
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M.Sc. (Chemistry)The determination of 17 trace elements (As. Ba. Co. Cr. Cu. Mo. Nb. Ni. Pb. Rb. Sr. Th. U. V. Y. Zn and Zr) in uranium ores by X-ray fluorescence spectrometry was investigated in this study. The determination of major elements. however. was also necessary for the calculation of mass absorption coefficients. Major elements were determined on borate melts and trace elements on powder briquettes pressed at 7 t with a binder in liquid form. Initially a method was developed for the determination of the elements of interest in unmineralised rocks The rhodium tube was used for the Group 1 elements (As. Mo. Nb. Pb, Bb, Sr. Th, U. Y and Zr) and the gold tube for the Group 2 elements [Ba, Co. Cr. Cu. Ni. V and Zn). Background and peak overlap corrections were made by means of background and interference factors. Corrections for absorption of radiation by the sample were made by means of mass absorption coefficients. which were calculated from the major element composition or obtained from the relation between the inverse of the mass absorption coefficient and the intensity of the Compton scattering peak. Due to various problems. only the latter method was suitable for uranium ores. The high uranium content in uranium ores mainly affected the Group 1 elements. Because of the high intensity of various UL lines. large overlap corrections were necessary. while only a few completely interference-free background positions were available. Consequently. the Feather and Willis method was used for determining the background intensity at the peak positions as well as for mass absorption coefficients. As a result of the presence of the UL absorption edges both primarx and secondary mass absorption coefficients had to be used for matrix corrections. Furthermore. it was observed that the background intensity in the region of the uranium lines increases with increasing uranium content of the sample instead of the expected decrease due to the increasing mass absorption coefficient. This effect was greater for the LiF(11 0) crystal than for the LiF(100) and was attributed to the scattering of uranium lines in the spectrometer chamber. especially from the crystal. A method was developed to correct the measured intensities for this scattering effect. Calibration lines of the contribution from the scattering of uranium lines to the measured intensity at the different 28 positions versus the uranium peak intensity were plotted by using samples with various uranium concentrations (<2 %) and for which the mass absorption coefficients and concentrations of the various elements were known. The precision of the method was less than 2.5 % at concentrations greater than 50 ppm. With the exception of barium. detection limits varied between 1 and 5 ppm. Accurate results were obtained over large concentration ranges for various unmineralised samples and for uranium ores. The results of the analysis of a number of Karoo uranium ores are given.
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Schlicker, Christine. "Kristallstrukturen der C2B-Domäne von Rabphilin-3A und der PP2C-ähnlichen Phosphatase tPphA von Thermosynechococcus elongatus BP-1." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-B60B-B.
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"Die optimale benutting van steenkool met verwysing na grootte by Bosjesspruit Steenkoolmyn." Thesis, 2012. http://hdl.handle.net/10210/6882.
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M.Phil.The study was undertaken at Bosjesspruit, one of the Sasol Collieries, to investigate aspects that contribute to the degradation of coal. Bosjesspruit is penalised with more than nine million rands per year for fine coal that exceeds the set limits. Compliance to quality is the main reason. The cost is directly deducted from the profit. The quality of coal is of importance for the effectiveness of the gasifying process. A feasibility study has indicated that this study is viable. Various factors in the process were studied to identify the system deviations such as: coal bunkers, section and main conveyor belts, geology, production section activities and coal production equipment. A literature study was done and time was spent to become conversant with the coal transport system. The process is described from where the coal is mined, through the handling action up to where it is fed into the Sasol plant gasifiers. Several coal samples of the identified bottleneck areas were taken and analysed. The four main areas that were studied are: Loading actions at East 700 bunker. Incline shaft transfer chute. The horizontal bunker on surface. The South section conveyor chutes. The free-flow technology was researched and developed for an acceptable chute design. The design is now computerised and in use at Sasol Collieries. The current design and its restrictions are compared with the proposed designs to indicate the improvements. A detailed cost analysis was done to determine the expenditures such as: Penalties for fine coal. The cost of adaptability and redesign. - Forecast cost savings after the redesigns are implemented. - Cost to produce coal as well as the income for Bosjesspruit. An economical evaluation indicates that all the suggested solutions are economically justifiable. The results of the study indicate several suggested solutions to overcome the identified bottlenecks. It is further suggested that results of this study are also implemented at the other Sasol mines as well as the mines that are being developed.
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Barwise, Maria Elizabeth Danetta. "Reg op regsverteenwoordiging met spesifieke verwysing na 'n handves van menseregte." Diss., 1995. http://hdl.handle.net/10500/18065.
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Text in AfrikaansThe Constitution of the Republic of South Africa 200 of 1993 that took effect from 27 April 1994, gave an accused a constitutional right to legal representation. Although the right of an accused to be legally represented formed an integral part of the South African Law, the Constitution gave him the further right ofbeing provided with legal representation at the cost of the State . For the practical implementation ofthe Constitution extensive changes to the current Legal Aid Scheme are essential . This work is an investigation of the justification of an accused's right to legal representation and the right to be provided with legal representation at the expense of the State . The practical implementation of the Constitution is discussed and suggestions are made that might be a solution to the current problem of the provision of legal aid at the State's expense.
Die Grondwet van die Republiek van Suid-Afrika 200 van 1993 wat op 27 April 1994 in werking getree het, het konstitusionele erkenning verleen aan 'n beskuldigde se reg op regsverteenwoordiging . Alhoewel die reg van 'n beskuldigde tot regsverteenwoordiging inherent deel van die Suid-Afrikaanse reg was het die Grondwet verder gegaan en 'n beskuldigde die reg gegee om op staatskoste van regsverteenwoordiging voorsien te word . Om die Grondwet prakties uitvoerbaar te maak sal ingrypende veranderings aan die huidige Regshulpskema noodsaaklik wees . Hierdie werk behels 'n regshistoriese - en regsvergelykende studie van die reg van 'n beskuldigde tot regsverteenwoordiging en die reg om op staatskoste van regshulp voorsien te word . Die praktiese uitvoerbaarheid van die Grondwet word bespreek en voorstelle word aan die hand gedoen om die huidige situasie, wat betref die verskaffing van regshulp op staatskoste, te verbeter .
Criminal & Procedural Law
LL. M.
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Strydom, Chanette. "Die benutting van temperamentanalise in 'n bemagtingsprogram vir ouers met kinders in die middelkinderjare (Afrikaans)." Thesis, 2006. http://hdl.handle.net/2263/23833.
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This research was aimed at the development, implementation and evaluation of an empowerment programme for parents with children in their middle childhood, focused on temperament analysis. The motivation for this study stemmed from the absence of relevant programmes in the field of social work concerning different temperaments and needs of children that parents does not understand or meet. Intervention research was applied. A two-phase research approach was undertaken. In phase 1, a qualitative research was used to do a need assessment. The need assessment was done by means of two focus group discussions with ten parents in each group. The following research question was formulated for this phase: What is the needs of parents related to a programme that focus on temperament analysis for children in there middle childhood. This data complemented the literature study which was undertaken and provided information that established the contents of the empowerment programme. The research question could therefore be answered. The qualitative approach was used in phase 2 as the single-system design. The following research hypothesis was formulated for this phase: If an empowerment programme that includes a temperament analysis is attempted with parents, a significant change in their knowledge in handling and understanding of their children should realise. The empowerment programme for parents with children in their middle childhood consisted of six sessions and was implemented over a period of two weeks. Four parents and one single parent undertook the empowerment programme. A group assessment was undertaken with the five children of the parents who attended the empowerment programme. The focus of the group assessment was to determine a tendency to respond. The self-designed questionnaire was completed prior to the empowerment programme and thereafter. This instrument of measurement confirmed the hypothesis. Conclusions and recommendations for the utilization of the programme in future research were formulated as a result of the research study.Thesis (PhD (Human Movement Science))--University of Pretoria, 2007.
Social Work and Criminology
unrestricted
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Le, Roux Anna Christina. "Ondersoek na die leefwêreld van die leergestremde adolessent met die oog op riglyne vir hulpverlening." Thesis, 1994. http://hdl.handle.net/10500/17180.
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Text in AfrikaansDie doel van die ondersoek was om insig in die leefwereld van die leergestremde adolessent te bekom, ten einde probleemareas wat doeltreffende aanpassing in die leefwereld verhinder, bloot te le. In die probleemontleding het die volgende aspekte na vore getree: Daar is 'n groeiende bewuswording onder navorsers dat die sosiaalemosionele probleme wat die leergestremde adolessent ervaar, duideliker aangespreek moet word. Die noodsaaklikheid om die leergestremde adolessent vir volwassenheid voor te berei, word toenemend besef. In die literatuurstudie is die tydperk van adolessensie, leergestremdheid as fenomeen, en die leefwereld van die leergestremde adolessent onderskeidelik bespreek. Enkele gevolgtrekkinge word aangestip: Adolessensie word gekenmerk deur fisiese, kognitiewe, affektiewe, sosiale en morele ontwikkeling. Hierdie veranderinge hou implikasies in vir die adolessent se uitvoer van ontwikkelingstake, die ontplooiing van die selfkonsep en die groei na onafhanklikheid. Die fenomeen leergestremdheid openbaar 'n komplekse aard wat 'n persoon in sy totaliteit raak. Die manifestasies van leergestremdheid betrek die akademiese vordering sowel as die sosiaal-emosionele ontwikkeling van die individu. Die leergestremde adolessent se aanpassing in sy leefwereld word nadelig beinvloed deur sosiale vaardigheidstekorte, interpersoonlike verhoudingsprobleme, 'n gebrekkige selfkonsep, emosionele probleme, die gebruik van verdedigingsmeganismes en 'n verminderde strewe na onafhanklikheid. In die empiriese ondersoek is inligting oor die leergestremde adolessent se interpersoonlike verhoudinge, selfkonsep en emosionaliteit bekom. In die interpretasie van die data is veranderlikes waar die leergestremde ado l essente swakker aanpassing as die normal e populasie getoon het, eerstens geidentifiseer. Verskille wat by die leergestremde adolessente ten opsigte van geslag en ouderdomsgroep voorgekom het, is vervolgens uitgelig. Ten slotte is 'n faktorontleding uitgevoer ten einde 'n gemeenskaplikheid tussen die onderskeie veranderlikes te bepaal. Op grond van die bevindinge uit die literatuur en die empiriese studie, is riglyne vir hulpverlening geformuleer. Die navorsingsbevindinge is veral van belang vir onderwysers, ouers en ander opvoeders wat met die leergestremde adolessent gemoeid is.
The purpose of the study was to gain insight into the life-world of the learning disabled adolescent in order to reveal problems which prevent effective adjustment in the life-world. In the analysis of the problem the following aspects were prominent: It is recognised that the social-emotional problems experienced by the learning disabled adolescent should be addressed in greater depth. The need to prepare the learning disabled adolescent for adulthood is realised. In the literature study the period of adolescence, learning disabilities as a phenomenon, and the life-world of the learning disabled adolescent were discussed. The following conclusions can be mentioned: Adolescence is characterised by physical, cognitive, emotional, social and moral development. These changes have implications for the adolescent's accomplishment of developmental tasks, the development of the self-concept and the grow towards independence. Learning disabilities as a phenomenon reveals a complex nature that affects the total person. The manifestations of learning disabilities involve the academic progress and the social-emotional development of the individual. The adjustment of the learning disabled adolescent in his lifeworld is adversely affected by deficits in social skills, problematic interpersonal relationships, an inadequate self-concept, emotional problems, the use of defence mechanisms and an insufficient strive towards independence. In the empirical investigation information was obtained about the learning disabled adolescent's interpersonal relationships, self-concept and emotionality. In the interpretation of the data variables were identified where the learning disabled adolescents showed poorer adjustment than the normal population. Differences between learning disabled adolescents with regard to age and sex were highlighted next. Finally, a factor analysis was carried out to determine whether a communality exists among the respective variables. On the basis of the findings of the literature and the empirical study, guidelines for the rendering of aid were formulated. The research findings are especially important to teachers, parents and other educators involved with the learning disabled adolescent.
Psychology of Education
D. Ed. (Sielkundige Opvoedkunde)
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Silva, Catarina Santos. "A proporção corporal como factor adaptativo : comprimento relativo do membro inferior e o gasto energético de repouso." Master's thesis, 2016. http://hdl.handle.net/10400.5/13188.
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A presente tese contempla dois estudos e baseou-se nos dados recolhidos no âmbito do projecto de investigação Impacto do desporto federado, do desporto escolar e da actividade física regular feita após o horário escolar no estilo e qualidade de vida das crianças e dos adolescentes (6 a 11 anos) em função da sua idade óssea, um estudo transversal com duração de 3 anos, financiado pela Fundação para a Ciência e Tecnologia (FCT) (PTDC/DES/113156/2009).
O primeiro estudo investigou o papel do comprimento relativo do membro inferior na relação entre a massa livre de gordura e o gasto energético de repouso numa amostra de adolescentes (n = 611, 13.63 ± 1.87 anos). Estimou-se o comprimento relativo do membro inferior através da estatura e altura sentado [CRMI = (estatura - altura sentado)/estatura] e o gasto energético de repouso utilizando a equação de Müller. Identificou-se um efeito moderador do comprimento relativo do membro inferior através de um modelo de regressão linear múltipla (β = - 0.016; SE = 0.005; p = .003). A análise de covariância mostrou que adolescentes com um comprimento relativo do membro inferior superior têm um maior gasto energético de repouso por quilograma de massa livre de gordura [F(2,607) = 6.001; R2 = .114; p = .003].
O segundo estudo focou-se na validação relativa do Nível de Actividade Física (PAL) obtido através do Questionário Biossocial e para Avaliação das Rotinas de Vida Diárias em Crianças e Adolescentes, utilizando o ActiGraph GT3X como método de comparação. Analisou-se, igualmente, o impacto da inclusão das actividades durante os períodos de não utilização na qualidade dos dados da acelerometria. Uma amostra de 127 adolescentes (14.24 ± 1.95 anos) utilizou o ActiGraph durante cinco dias consecutivos (dois de fim-de-semana) e registou a duração e percepção de esforço de actividades realizadas fora dos períodos de utilização do acelerómetro. A mesma amostra preencheu o questionário RAPIL II, que incluía a duração e frequência de um largo conjunto de actividades semanais. A análise Bland-Altman baseada na regressão mostrou que a diferença média entre métodos foi de - 1.050 + 0.689PALmédio (LOA = - 0.71298 + 0.18962PALmédio, - 1.38702 + 1.18838PAL médio) e - 1.031 + 0.654PALmédio (LOA = - 0.33236 - 0.11106PALmédio, - 1.72964 + 1.41906PALmédio), incluindo ou excluindo da análise as actividades nos períodos de não utilização. O RAPIL II é válido em contexto populacional, apresentando uma boa concordância com o ActiGraph GT3X, mas não em contexto de avaliação individual. Deve ser considerada a inclusão das actividades em períodos de não utilização do acelerómetro.
Ambos os estudos abrem novos caminhos para futura investigação, quer no respeitante ao papel da proporção corporal na estimação das necessidades energéticas, quer na avaliação epidemiológica do Nível de Actividade Física, através de um método acessível e pouco dispendioso.The present thesis comprises two studies and was based on the data collected under the research project The impact of regular competitive sport, extracurricular school-based sport and out-of-school time physical activities on lifestyle and quality of life of children and adolescents (11 to 16 years old) considering their bone age, a 3-year cross-sectional study sponsored by the Science and Technology Foundation (FCT) (PTDC/DES/113156/2009). The first study investigated the role of relative leg length on resting energy expenditure-to-fat-free mass relationship in a sample of adolescents (n = 611, 13.63 ± 1.87 years). Relative leg length was estimated through height and sitting height [RLL = (height - sitting height)/height], and resting energy expenditure using Müller equation. A moderation effect of relative leg length was identified through a multiple linear regression model (β = - 0.016; SE = 0.005; p = .003). Analysis of covariance showed that adolescents with higher relative leg length have higher resting energy expenditure by kilogram of fat-free mass [F(2,607) = 6.001; R2 = .114; p = .003]. The second study focused on the relative validation of Physical Activity Level (PAL) obtained with the Biosocial and Daily Life Routines Questionnaire for Children and Youth (RAPIL II), using ActiGraph GT3X as comparison method. It was also analyzed the impact of including non-wear time activities on the accelerometry data quality. A sample of 127 adolescents (14.24 ± 1.95 years) used the ActiGraph GT3X during five consecutive days (two weekend days), and recorded the duration and perceived exertion of non-wear time activities. The same sample completed the RAPIL II questionnaire, which included the duration and frequency of a large set of week activities. Bland-Altman regression analysis showed a mean difference between methods of -1.050+0.689MeanPAL (LOA = -0.71298+0.18962MeanPAL, -1.38702+1.18838MeanPAL) and -1.031+0.654MeanPAL (LOA = -0.33236-0.11106MeanPAL, - 1.72964+1.41906MeanPAL) when non-wear time activities were included or excluded from analysis. RAPIL II is valid on a population basis, presenting good agreement with ActiGraph GT3X, but not for individual evaluation purposes. Consideration should be given to the inclusion of non-wear time activities. Both studies open new paths for future research, either regarding the role of body proportion in energy requirements estimation, or the epidemiological assessment of Physical Activity Level through an accessible and low-cost method.
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Muller, Catherina Elizabeth. "'n Ondersoek na die rol van werkontleding in die uitvoering van funksionele personeelbedrywighede met verwysing na die Stadsraad van Lichtenburg." Diss., 1997. http://hdl.handle.net/10500/17537.
Full textAbstract:
Text in AfrikaansWerkontleding word onderneem om die onderskeie funksies wat in 'n instelling uitgevoer word, te ontleed en te groepeer as pligte van individuele betrekkings wat in die proses ge1dentifiseer word. Inligting wat op grond van werkontleding verkry is, kan daartoe bydra dat die uitvoering van personeelfunksies doeltreffend en effektief geskied. 'n Li teratuurstudie en empiriese narvorsing is in hierdie·studie onderneem om te bepaal wat die rol van werkontleding in die ui tvoering van funksionele personeelbedrywighede in die Stadsraad van Lichtenburg is. Empiriese navorsing is onderneem in al die Departemente van die Stadsraad van Lichtenburg. Ten einde die doel van die studie te verwesenlik is vier navorsingsvrae gestel. Deur middel van vraelyste wat aan die teikengroep gestuur is, is data oor die navorsingsvrae ingesamel. Die empiriese studie het daarop gedui dat inligting verkry op grond van werkontleding wel kan bydra tot die effektiewe uitvoering van funksionele personeelbedrywighede. Dies studie het egter ui tgewys dat nie alle leidinggewende amptenare bewus is dat die inligting op grond van werkontleding verkry,. die uitvoering van hul personeelfunksies kan vergemaklik nie.
respective functions performed in an institution, as duties of individual jobs identified in the process. Information gathered on the basis of the job analysis, can contribute to the fact that the performing of personnel functions transpires efficiently and effectively. A literature study as well as empiricial research were undertaken in this study to determine ' what the role of job analyses is in the performing of functional personnel activities in the City Council of Lichtenburg. .on the basis of job analysis can definitely contribute to the effective performing of functional personnel activities. The study indicated however, that not all leadinq officials were aware that information gathered on the basis of job analysis, could expedite the performing of their personnel functions.
Public Administration
M.Admin. (Public Administration)
46
Van, Graan Carin. "'n Analitiese oorsig van Stefans Grové se Dansrapsodie - 'n Afrika-stad en Jeanne Zaidel - Rudolph se Fanfare Festival Overture met spesifieke verwysing na die aanwending van Afrika-etniese elemente (Afrikaans)." Diss., 2010. http://hdl.handle.net/2263/27653.
Full textAbstract:
Die hoofdoel van hierdie studie was om Dansrapsodie – ʼn Afrika-stad van Stefans Grové en Fanfare Festival Overture van Jeanne Zaidel-Rudolph ten opsigte van struktuur, melodie, ritme en instrumentasie te ontleed en sodoende vas te stel watter Afrika-etniese elemente gebruik word en hoe dit toegepas is. ʼn Vergelykende studie is gedoen om vas te stel of daar enige ooreenkomste of verskille tussen die twee werke is. Verskeie skripsies, verhandelings en proefskrifte oor werke van Grové en Zaidel- Rudolph is geraadpleeg. Die skrywer kon nie gepubliseerde weergawes van Dansrapsodie – ʼn Afrika-stad en Fanfare Festival Overture opspoor nie, daarom is die ontleding met behulp van afskrifte van die handgeskrewe manuskripte onderneem. Daar is gereeld na die CD-opnames van albei werke (op die Claremont GSE-etiket) geluister. Die verhandeling bestaan uit ses hoofstukke. In die eerste hoofstuk word die agtergrond en motivering vir die studie uiteengesit en Hoofstuk 2 bevat kort biografieë van Grové en Zaidel-Rudolph. Grové se Dansrapsodie – ʼn Afrika-stad word in Hoofstuk 3 ontleed en verskillende Afrika-etniese elemente word beskryf soos wat dit van toepassing op die analise is. Zaidel-Rudolph se Fanfare Festival Overture word in Hoofstuk 4 op dieselfde wyse as Dansrapsodie – ʼn Afrika-stad ontleed. Die laaste twee hoofstukke (Hoofstuk 5 en 6) bevat ʼn vergelyking tussen die aanwending van Afrika-etniese elemente in die twee komposisies, asook gevolgtrekkings en voorstelle vir verdere studie. Die belangrikste gevolgtrekkings is die volgende: - Afrika-etniese elemente word in albei werke op só ʼn manier aangewend dat die komposisie vir ʼn Westerse orkes toeganklik is.
- In albei werke se struktuur word die roep-en-antwoord-beginsel en herhalende melodieë wat tydens elke herhaling effens gewysig word (permutasie) aangewend. Die melodiese inhoud word deur die mineur terts (ʼn interval van die pentatoniese toonleer) en twyfelagtige tonaliteite oorheers. Ritmiese ostinaatpatrone, die 12/8-metrum en poliritmiek in die Afrika-deel van Zaidel-Rudolph se komposisie bewerkstellig onmiddellik Afrika-etniese assosiasies. Die bongo-tromme en marimba kom in albei komposisies as Afrika-instrumente voor.
- Grové en Zaidel-Rudolph benader die aanwending van Afrika-etniese elemente in Westerse musiek op verskillende maniere.
- African ethnic elements are applied in such a way that both compositions are accessible for Western (“art music”) orchestras.
- In both compositions’ structure the call-and-response principle and repeated melodies (that are modified during each repeat) are applied. Both works’melodic content is dominated by the interval of a minor 3rd (an interval from the pentatonic scale) and an ambiguous tonality. Rhythmic ostinatos, the 12/8 metre and polyrhythm in the African part of Zaidel-Rudolph’s Fanfare Festival Overture immediately bring about African ethnic associations. The bongos and marimba as African instruments can be found in both works.
- Grové and Zaidel-Rudolph approach the application of African ethnic elements in Western art music in different ways.
Dissertation (MMus)--University of Pretoria, 2010.
Music
unrestricted