Journal articles: 'MET values'

1

Harrell, J. S., R. G. McMurray, S. I. Bangdiwala, C. D. Baggett, P. F. Pearce, and M. Pennell. "DETERMINING MET VALUES IN CHILDREN AND ADOLESCENTS." Medicine & Science in Sports & Exercise 35, Supplement 1 (May 2003): S342. http://dx.doi.org/10.1097/00005768-200305001-01900.

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Shephard, R. J. "Accelerometer Output and MET Values of Common Physical Activities." Yearbook of Sports Medicine 2011 (January 2011): 121–23. http://dx.doi.org/10.1016/j.yspm.2010.12.003.

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KOZEY, SARAH L., KATE LYDEN, CHERYL A. HOWE, JOHN W. STAUDENMAYER, and PATTY S. FREEDSON. "Accelerometer Output and MET Values of Common Physical Activities." Medicine & Science in Sports & Exercise 42, no. 9 (September 2010): 1776–84. http://dx.doi.org/10.1249/mss.0b013e3181d479f2.

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Lee, Miyoung, Weimo Zhu, Bo Fernhall, and Brad Hedrick. "Estimating MET Values of Persons with SCI Using Heart Rate." Medicine & Science in Sports & Exercise 40, Supplement (May 2008): S205. http://dx.doi.org/10.1249/01.mss.0000322342.75619.5b.

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Shiri, Jalal. "Evaluation of a neuro‐fuzzy technique in estimating pan evaporation values in low‐altitude locations." Meteorological Applications 26, no. 2 (November 28, 2018): 204–12. http://dx.doi.org/10.1002/met.1753.

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Alessandro, Adelia P. "Relationship between values and trends of two circulation indices and temperature and rainfall in Argentina." Meteorological Applications 19, no. 4 (July 13, 2011): 427–42. http://dx.doi.org/10.1002/met.274.

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Correa-Bautista, Jorge Enrique, Katherine González-Ruíz, Andrés Vivas, Héctor Reynaldo Triana-Reina, Javier Martínez-Torres, Daniel Humberto Prieto-Benavides, Hugo Alejandro Carrillo, et al. "Comparison of Three Adiposity Indexes and Cutoff Values to Predict Metabolic Syndrome Among University Students." Metabolic Syndrome and Related Disorders 15, no. 7 (September 2017): 363–70. http://dx.doi.org/10.1089/met.2017.0016.

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Tudor-Locke, Catrine, Barbara E. Ainsworth, Tracy L. Washington, and Richard Troiano. "Assigning Metabolic Equivalent Values to the 2002 Census Occupational Classification System." Journal of Physical Activity and Health 8, no. 4 (May 2011): 581–86. http://dx.doi.org/10.1123/jpah.8.4.581.

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Background:The Current Population Survey (CPS) and the American Time Use Survey (ATUS) use the 2002 census occupation system to classify workers into 509 separate occupations arranged into 22 major occupational categories.Methods:We describe the methods and rationale for assigning detailed Metabolic Equivalent (MET) estimates to occupations and present population estimates (comparing outputs generated by analysis of previously published summary MET estimates to the detailed MET estimates) of intensities of occupational activity using the 2003 ATUS data comprised of 20,720 respondents, 5323 (2917 males and 2406 females) of whom reported working 6+ hours at their primary occupation on their assigned reporting day.Results:Analysis using the summary MET estimates resulted in 4% more workers in sedentary occupations, 6% more in light, 7% less in moderate, and 3% less in vigorous compared with using the detailed MET estimates. The detailed estimates are more sensitive to identifying individuals who do any occupational activity that is moderate or vigorous in intensity resulting in fewer workers in sedentary and light intensity occupations.Conclusions:Since CPS/ATUS regularly captures occupation data it will be possible to track prevalence of the different intensity levels of occupations. Updates will be required with inevitable adjustments to future occupational classification systems.

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Iversen, G. A. "Values Dissonance." Aboriginal Child at School 13, no. 2 (May 1985): 12–20. http://dx.doi.org/10.1017/s0310582200013705.

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Within the North-west Aboriginal reserve of South Australia a traditional system of tribal Aboriginal culture is currently maintained and reproduced. The observable culture of the Aboriginal people of this region retains distinct traditional elements and a life-style very different from that of the dominant white Australian society. Within this socio-cultural setting, schools which have been operational in some form since the establishment of the settlements face a unique challenge. Unfortunately, the challenge has, in most cases, not been successfully met, since the lack of success of Aboriginal students in the school situation is a damning indictment of the introduced Western system of schooling. Success is measured by the achievement of the set goals of the school, but frequently these reflect a white Australian value system.

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Dankova, Desislava. "When visual content met storytelling." Yearbook of Department Mass Communications 1 (October 7, 2020): 137–55. http://dx.doi.org/10.33919/ydmc.19.1.8.

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The current text introduces the idea of communicating through images. The tool is increasingly visible in companies' communication strategies. The prerequisites that lead to the development of this type of communication are discussed, focusing on one of the most used social media – Instagram. A parallel is drawn between the nature of the platform and the ability to find an intersection between visual content and storytelling. At the end of the text, two of the most successful examples from the corporate world are presented and their approach of engaging Instagram followers with the help of experiences in order to convert them into customers while demonstrating the company's philosophy and values.

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Stanišić, Nikola, Nenad Parunović, Slaviša Stajić, Milica Petrović, Čedomir Radović, Dušan Živković, and Maja Petričević. "Differences in meat colour between free-range Swallow Belly Mangalitsa and commercially reared Swedish Landrace pigs during 6 days of vacuum storage." Archives Animal Breeding 59, no. 1 (April 1, 2016): 159–66. http://dx.doi.org/10.5194/aab-59-159-2016.

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Abstract. The influence of storage on meat colour differences between free-range Swallow Belly Mangalitsa (MA, n = 19) and commercially reared Swedish Landrace (SL, n = 17) pigs, are investigated in the present study. Proximate composition analyses were done on fresh samples of M. longissimus thoracis (LT) and M. gluteus medius (GM), while pH values and colour quality attributes were determined on fresh cuts of the muscles (day 1) and after 3 and 6 days of vacuum storage at 4 ± 1 °C. MA pork had a significantly higher share of intramuscular fat, a darker colour, a higher deoxymyoglobin (Mb) content and oxy ∕ met (oxymyoglobin ∕ metmyoglobin) ratio, higher pH24 h values and a slower pH decline compared to the control SL group (P < 0.05). Greater changes in myoglobin forms during storage were observed in MA pork, which were reflected in a significant decrease in the content of Mb and an increase in the oxy ∕ met ratio (P < 0.05).After 6 days of vacuum storage, higher pH6d values, a lower metmyoglobin (MetMb) content and a higher oxy ∕ met ratio of MA pork lead to the conclusion that aged meat from free-range Swallow Belly Mangalitsa pigs had better colour quality compared to Swedish Landrace pigs.

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12

Wentzell, J. J. B., C. L. Schiller, and G. W. Harris. "Measurements of HONO during BAQS-Met." Atmospheric Chemistry and Physics Discussions 10, no. 6 (June 21, 2010): 15295–323. http://dx.doi.org/10.5194/acpd-10-15295-2010.

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Abstract. Measurements of nitrous acid (HONO) were performed as part of the 2007 Border Air Quality and Meteorology Study (BAQS-Met) at the Harrow Ontario supersite between 20 June and 10 July 2007. Nitrous acid is an important precursor of the hydroxy radical and understanding its chemistry is important to understanding daytime oxidation chemistry. The HONO measurements were made using a custom built Long Path Absorption Photometer (LOPAP). The goal of this work was to shed light on sources of daytime HONO in the border region. During the course of the campaign HONO mixing ratios consistently exceeded expected daytime values by as much as a factor of 6. Mean daytime concentrations of 61 pptv were observed. While HONO decay began at sunrise, minimum HONO values were not measured until the late afternoon. There was little difference between the daytime (mean=1.5%) and night-time (mean=1.7%) ratios of HONO/NO2. Thus there was a very strong daytime source of HONO which is consistent with other recent studies. Correlations of daytime HONO production with a variety of chemical and meteorological parameters indicate that production is dependent on UV radiation, NO2 and water vapour but is not consistent with a simple gas phase process. Apparent rate constants for the production of HONO from photolyticly excited NO2 and water vapour vary from 2.8–7.8×10−3 molec−1 s−1, during the campaign.

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13

Jiang, Shi-Guang, Neng-Xia Pan, Meng-Jie Chen, Xiu-Qi Wang, Hui-Chao Yan, and Chun-Qi Gao. "Effects of Dietary Supplementation with dl-Methionine and dl-Methionyl-dl-Methionine in Breeding Pigeons on the Carcass Characteristics, Meat Quality and Antioxidant Activity of Squabs." Antioxidants 8, no. 10 (October 1, 2019): 435. http://dx.doi.org/10.3390/antiox8100435.

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This study aimed to investigate the effects of dietary supplementation with dl-methionine (dl-Met) and dl-methionyl-dl-methionine (dl-Met-Met) in breeding pigeons on the carcass characteristics, meat quality and antioxidant activity of squabs. A total of 324 pairs of breeding pigeons were selected and allotted to 9 treatments in a completely randomized design, and the birds were fed dietary treatments for 45 d, including a Met-deficient basal diet (BD, crude protein = 15%, Met = 0.25%) and BD + 0.15%, 0.30%, 0.45%, or 0.60% dl-Met or dl-Met-Met diets. Compared with the diet fed to the BD group, dietary dl-Met or dl-Met-Met supplementation effectively increased the carcass yield, semieviscerated yield, eviscerated yield, breast muscle yield, thigh muscle yield, a* value, catalase activity, total superoxide dismutase activity and glutathione peroxidase activity, but decreased the L* value, malonaldehyde concentration, drip loss and cooking loss of squabs (p < 0.05). The relative bioavailability values of dl-Met-Met relative to those of dl-Met were 467% and 376% based on carcass yield and breast muscle yield, respectively (p < 0.001). Moreover, dl-Met-Met was more effective than dl-Met in decreasing the drip loss and improving the antioxidant activity of the breast and thigh muscles of squabs (p < 0.05). As a source of Met, dl-Met-Met, rather than dl-Met, was more beneficial to squabs.

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Wentzell, J. J. B., C. L. Schiller, and G. W. Harris. "Measurements of HONO during BAQS-Met." Atmospheric Chemistry and Physics 10, no. 24 (December 23, 2010): 12285–93. http://dx.doi.org/10.5194/acp-10-12285-2010.

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Abstract. Measurements of nitrous acid (HONO) were performed as part of the 2007 Border Air Quality and Meteorology Study (BAQS-Met) at the Harrow, Ontario, Canada supersite between 20 June and 10 July 2007. Nitrous acid is an important precursor of the hydroxyl radical and understanding its chemistry is important to understanding daytime oxidation chemistry. The HONO measurements were made using a custom built Long Path Absorption Photometer (LOPAP). The goal of this work was to shed light on sources of daytime HONO in the border region. During the course of the campaign HONO mixing ratios consistently exceeded expected daytime values by more than a factor of 6. Mean daytime mixing ratios of 61 pptv were observed. While HONO decay began at sunrise, minimum HONO values were measured during the late afternoon. There was little difference between the daytime (mean = 1.5%) and night-time (mean = 1.7%) ratios of HONO/NO2, thus there was a very strong daytime source of HONO which is consistent with other recent studies. Correlations of daytime HONO production with a variety of chemical and meteorological parameters indicate that production is dependent on UV radiation, NO2 and water vapour but is not consistent with a simple gas phase process. Apparent rate constants for the production of HONO from photolyticaly excited NO2 and water vapour vary from 2.8–7.8×10−13 cm3 molec−1 s−1, during the campaign. These results appear to be consistent with the heterogeneous conversion of NO2 enhanced by photo-excitation.

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15

Jones, Kristofer J., Benjamin V. Kelley, Armin Arshi, David R. McAllister, and Peter D. Fabricant. "Comparative Effectiveness of Cartilage Repair With Respect to the Minimal Clinically Important Difference." American Journal of Sports Medicine 47, no. 13 (May 13, 2019): 3284–93. http://dx.doi.org/10.1177/0363546518824552.

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Background: Recent studies demonstrated a 5% increase in cartilage repair procedures annually in the United States. There is currently no consensus regarding a superior technique, nor has there been a comprehensive evaluation of postoperative clinical outcomes with respect to a minimal clinically important difference (MCID). Purpose: To determine the proportion of available cartilage repair studies that meet or exceed MCID values for clinical outcomes improvement over short-, mid-, and long-term follow-up. Study Design: Systematic review and meta-analysis. Methods: A systematic review was performed via the Medline, Scopus, and Cochrane Library databases. Available studies were included that investigated clinical outcomes for microfracture (MFX), osteoarticular transfer system (OATS), osteochondral allograft transplantation, and autologous chondrocyte implantation/matrix-induced autologous chondrocyte implantation (ACI/MACI) for the treatment of symptomatic knee chondral defects. Cohorts were combined on the basis of surgical intervention by performing a meta-analysis that utilized inverse-variance weighting in a DerSimonian-Laird random effects model. Weighted mean improvements in International Knee Documentation Committee (IKDC), Lysholm, and visual analog scale for pain (VAS pain) scores were calculated from preoperative to short- (1-4 years), mid- (5-9 years), and long-term (≥10 years) postoperative follow-up. Mean values were compared with established MCID values per 2-tailed 1-sample Student t tests. Results: A total of 89 studies with 3894 unique patients were analyzed after full-text review. MFX met MCID values for all outcome scores at short- and midterm follow-up with the exception of VAS pain in the midterm. OATS met MCID values for all outcome scores at all available time points; however, long-term data were not available for VAS pain. Osteochondral allograft transplantation met MCID values for IKDC at short- and midterm follow-up and for Lysholm at short-term follow-up, although data were not available for other time points or for VAS pain. ACI/MACI met MCID values for all outcome scores (IKDC, Lysholm, and VAS pain) at all time points. Conclusion: In the age of informed consent, it is important to critically evaluate the clinical outcomes and durability of cartilage surgery with respect to well-established standards of clinical improvement. MFX failed to maintain VAS pain improvements above MCID thresholds with follow-up from 5 to 9 years. All cartilage repair procedures met MCID values at short- and midterm follow-up for IKDC and Lysholm scores; ACI/MACI and OATS additionally met MCID values in the long term, demonstrating extended maintenance of clinical benefits for patients undergoing these surgical interventions as compared with MFX.

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Yang, Fan, and George N. Phillips Jr. "Crystal Structures of CO−, Deoxy- and Met-myoglobins at Various pH Values." Journal of Molecular Biology 256, no. 4 (March 1996): 762–74. http://dx.doi.org/10.1006/jmbi.1996.0123.

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17

LEE, MIYOUNG, WEIMO ZHU, BRAD HEDRICK, and BO FERNHALL. "Estimating MET Values Using the Ratio of HR for Persons with Paraplegia." Medicine & Science in Sports & Exercise 42, no. 5 (May 2010): 985–90. http://dx.doi.org/10.1249/mss.0b013e3181c0652b.

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18

Prelog, Andrew J., Kenneth J. Berry, and Paul W. Mielke. "Resampling Permutation Probability Values for Cronbach's Alpha." Perceptual and Motor Skills 108, no. 2 (April 2009): 431–38. http://dx.doi.org/10.2466/pms.108.2.431-438.

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A permutation procedure to compute a resampling probability value and empirical quantile limits is provided for Cronbach's alpha measure of internal reliability. The underlying assumptions for the conventional use of alpha are discussed. The use of a permutation test for Cronbach's alpha is highlighted as a valuable tool when sample sizes are small and necessary assumptions cannot be met.

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Barnett, Rachel K., Cory Greever, Karen Yagi, Brendan Rhoan, and Sarah Kozey Keadle. "Reexamining the Energy Cost of Sedentary Behaviors From the 2011 Adult Compendium." Journal of Physical Activity and Health 18, no. 2 (February 1, 2021): 206–11. http://dx.doi.org/10.1123/jpah.2020-0333.

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Background: This study reexamines the energy cost of lower intensity activities compared to the 2011 Adult Compendium of Physical Activities. Methods: Participants (n = 32, age = 35 [13.8] y, 16 females) wore a portable metabolic system (COSMED), during 5 different conditions: sitting quietly, watching TV, sitting while working, driving, and walking at 2.0 mph. The metabolic equivalent (MET) values (VO2 mL·kg−1·min−1/3.5 mL·kg−1·min−1) were calculated. Results: The mean (SD) MET value for driving (1.46 [0.24]) was significantly lower than the Adult Compendium value of 2.5 (P < .001). Driving and slow walking have similar Adult Compendium values, but driving METs were significantly lower than slow walking (P < .001). Driving was similar to sitting while working (1.32 [0.25] METs, P > .05) and yielded significantly higher MET values than quiet sitting (1.08 [0.23] METs, P < .001) and watching TV (1.12 [0.22] METs, P < .001), both of which were lower than their respective Adult Compendium MET values. Conclusion: Existing Adult Compendium METs are significantly higher than measured METs for driving, which more closely correspond to sedentary behaviors than slow walking. The TV and quiet sitting also differed from their Adult Compendium values, which should be updated to reflect these findings, given that researchers and practitioners rely on Adult Compendium MET values to estimate energy cost.

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20

Schürr, Diether. "Der weiße Met im altenglischen Finnsburgfragment." Amsterdamer Beiträge zur älteren Germanistik 76, no. 3 (December 1, 2016): 353–62. http://dx.doi.org/10.1163/18756719-12340033.

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Two of the traditional ‘beasts of battle’ appear in the Finnsburh fragment as græghama ‘grey-coat’ (wolf) and hræfen + sweart ‘raven’ + ‘black’. Later on comes swa noc hwitne medo, i.e., an unclear swa noc (with s- required for alliteration) and ‘white mead’, contrasting with the black raven attracted by the fight. It is proposed that a third association between an animal and a colour can be recognised here by emending to *swanhwitne medo, ‘swan-white mead’, thus strengthening this contrast while simultaneously declaring a refined ethic, namely, sacrificing life, not for gold, as usual in the traditional heroic poetry, but for immaterial values symbolised by this mead, which is brighter than gold.

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21

Kim, Jooseok, Kyung Eui Park, Yoo-Seong Jeong, YeongMun Kim, Hayeon Park, Ji-Hye Nam, Kyungsoo Jung, et al. "Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer." Cancers 12, no. 6 (June 15, 2020): 1575. http://dx.doi.org/10.3390/cancers12061575.

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The receptor tyrosine kinase c-MET regulates processes essential for tissue remodeling and mammalian development. The dysregulation of c-MET signaling plays a role in tumorigenesis. The aberrant activation of c-MET, such as that caused by gene amplification or mutations, is associated with many cancers. c-MET is therefore an attractive therapeutic target, and inhibitors are being tested in clinical trials. However, inappropriate patient selection criteria, such as low amplification or expression level cut-off values, have led to the failure of clinical trials. To include patients who respond to MET inhibitors, the selection criteria must include MET oncogenic addiction. Here, the efficacy of ABN401, a MET inhibitor, was investigated using histopathologic and genetic analyses in MET-addicted cancer cell lines and xenograft models. ABN401 was highly selective for 571 kinases, and it inhibited c-MET activity and its downstream signaling pathway. We performed pharmacokinetic profiling of ABN401 and defined the dose and treatment duration of ABN401 required to inhibit c-MET phosphorylation in xenograft models. The results show that the efficacy of ABN401 is associated with MET status and they highlight the importance of determining the cut-off values. The results suggest that clinical trials need to establish the characteristics of each sample and their correlations with the efficacy of MET inhibitors.

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Ahmadani, Muhammad Yakoob, Rubina Hakeem, Asher Fawwad, Abdul Basit, and A. Samad Shera. "Determination of Reference Values for Elevated Fasting and Random Insulin Levels and their Associations with Metabolic Risk Factors Among Rural Pakistanis from Sindh Province." Metabolic Syndrome and Related Disorders 6, no. 2 (June 2008): 143–48. http://dx.doi.org/10.1089/met.2007.0031.

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23

Mendelsohn, Marissa E., Denise M. Connelly, Tom J. Overend, and Robert J. Petrella. "Validity of Values for Metabolic Equivalents of Task During Submaximal All-Extremity Exercise and Reliability of Exercise Responses in Frail Older Adults." Physical Therapy 88, no. 6 (June 1, 2008): 747–56. http://dx.doi.org/10.2522/ptj.20070161.

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Background and Purpose Physical therapists and rehabilitation professionals in hospital and long-term care centers are using all-extremity semirecumbent exercise machines in their treatment programs. This study was undertaken to investigate the concurrent validity of values for software-generated metabolic equivalents of task (MET) from an all-extremity semirecumbent exercise machine and directly measured values for MET from a portable metabolic unit across a range of submaximal exercise intensities. A second purpose of this study was to determine the test-retest reliability of oxygen consumption and heart rate responses in older adults between standardized sessions of submaximal all-extremity aerobic exercise. Subjects and Methods The study participants were 18 older adults (mean age=82 years, SD=5; 3 women, 15 men) who were living in long-term care centers and who completed 2 test sessions of a standardized exercise protocol 1 week apart. The exercise protocol included a warm-up period, three 4-minute stages of exercise at incremental workload levels, and a cool-down period. The breath-by-breath metabolic data from the portable metabolic unit, heart rate, MET values from the exercise machine, Borg Rating of Perceived Exertion, and watts were recorded continuously throughout the exercise protocol. Results The concurrent validity of the MET values from the exercise machine and the portable metabolic unit ranged from very good to excellent on both day 1 and day 2 (r=.85–.97). The test-retest reliability of subjects' heart rate responses and MET values from the portable metabolic unit was moderate to high across submaximal exercise intensities (intraclass correlation coefficients [2,1]=.85–.91). Discussion and Conclusion The exercise machine software-generated MET values were representative of directly measured oxygen consumption values across a range of submaximal intensities during all-extremity semirecumbent exercise in older adults with multisystem impairments.

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Trifunovic, Dejan. "Single object auctions with interdependent values." Ekonomski anali 56, no. 188 (2011): 125–69. http://dx.doi.org/10.2298/eka1188125t.

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This paper reviews single object auctions when bidders? values of the object are interdependent. We will see how the auction forms could be ranked in terms of expected revenue when signals that bidders have about the value of the object are affiliated. In the discussion that follows we will deal with reserve prices and entry fees. Furthermore we will examine the conditions that have to be met for English auction with asymmetric bidders to allocate the object efficiently. Finally, common value auctions will be considered when all bidders have the same value for the object.

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Peng, Yunling, Karunia Adhiputra, Anneline Padayachee, Heather Channon, Minh Ha, and Robyn Dorothy Warner. "High Oxygen Modified Atmosphere Packaging Negatively Influences Consumer Acceptability Traits of Pork." Foods 8, no. 11 (November 13, 2019): 567. http://dx.doi.org/10.3390/foods8110567.

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Current trends in meat packaging have seen a shift from conventional overwrap to vacuum packing (VAC) and modified atmosphere packaging (MAP). The aim of this experiment was to investigate the effects of high oxygen MAP (HiOxMAP) of pork loins compared with vacuum packed (VAC) on eating quality and colour, after storage in simulated illuminated retail display conditions. Pork loins (n = 40) were cut and stored under two packaging methods (HiOxMAP, 80% O2, 20% CO2; VAC) for up to 14 days, with samples taken at various times for measurements. After 7 days of storage, HiOxMAP samples exhibited inferior consumer acceptability for tenderness, flavor, overall liking, quality and re-purchase intention as well as higher shear force and hardness, relative to VAC samples (p < 0.05 for all). Loins stored in HiOxMAP had higher lightness (L*), redness (a*) and yellowness (b*) values at 3 and 7 days, but lower ratio of oxymoglobin to metmyoglobin (oxy/met) values in the meat surface at 14 days of display, relative to VAC samples (p < 0.05 for all). The oxy/met ratio declined from 2.3 to 1.7 between days 3 and 14 of display in HiOxMAP samples (p < 0.05), whereas the ratio was similar and stayed relatively high for VAC samples. VAC samples produced consistently higher colour values (a*, b*, oxy/met) when left to bloom 30 min after removal from packaging (p < 0.05). Lipid oxidation values, measured using thiobarbituric acid reactive substances, in HiOxMAP pork loins, were higher at all time points compared to VAC during the 14 day storage period (p < 0.05). The use of vacuum packing for retail shelves, should be considered as the preferred option, over HiOxMAP.

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Shephard, R. J. "2011 Compendium of Physical Activities: A Second Update of Codes and MET Values." Yearbook of Sports Medicine 2012 (January 2012): 126–27. http://dx.doi.org/10.1016/j.yspm.2011.08.057.

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Lee, Geun Dong, Seung Eun Lee, Doo-Yi Oh, Dan-bi Yu, Hae Min Jeong, Jooseok Kim, Sungyoul Hong, et al. "MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values." Journal of Thoracic Oncology 12, no. 8 (August 2017): 1233–46. http://dx.doi.org/10.1016/j.jtho.2017.04.031.

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Heydenreich, Juliane, Yves Schutz, Katarina Melzer, and Bengt Kayser. "Comparison of Conventional and Individualized 1-MET Values for Expressing Maximum Aerobic Metabolic Rate and Habitual Activity Related Energy Expenditure." Nutrients 11, no. 2 (February 22, 2019): 458. http://dx.doi.org/10.3390/nu11020458.

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The maximum aerobic metabolic rate can be expressed in multiple metabolically equivalent tasks (MET), i.e., METmax. The purpose was to quantify the error when the conventional (3.5 mL∙kg−1∙min−1) compared to an individualized 1-MET-value is used for calculating METmax and estimating activity energy expenditure (AEE) in endurance-trained athletes (END) and active healthy controls (CON). The resting metabolic rate (RMR, indirect calorimetry) and aerobic metabolic capacity (spiroergometry) were assessed in 52 END (46% male, 27.9 ± 5.7 years) and 53 CON (45% male, 27.3 ± 4.6 years). METmax was calculated as the ratio of VO2max over VO2 during RMR (METmax_ind), and VO2max over the conventional 1-MET-value (METmax_fix). AEE was estimated by multiplying published MET values with the individual and conventional 1-MET-values. Dependent t-tests were used to compare the different modes for calculating METmax and AEE (α = 0.05). In women and men CON, men END METmax_fix was significantly higher than METmax_ind (p < 0.01), whereas, in women END, no difference was found (p > 0.05). The conventional 1-MET-value significantly underestimated AEE in men and women CON, and men END (p < 0.05), but not in women END (p > 0.05). The conventional 1-MET-value appears inappropriate for determining the aerobic metabolic capacity and AEE in active and endurance-trained persons.

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Md. Arfan Ali, Md Arfan Ali. "Quality and Biochemical Changes of ‘Grand Nain’ Bananas during Shelf Life." journal of King Abdulaziz University - Meteorology, Environment and Arid Land Agriculture Sciences 28, no. 1 (February 20, 2019): 41–54. http://dx.doi.org/10.4197/met.28-1.5.

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. Quality attributes, antioxidant compounds, free radical scavenging capacity (FRSC, DPPH IC50 value) and enzymes activities of ‘Grand Nain’bananas were investigated during shelf life at 20±2oC and 60-70% RH for 7 days. Weight loss, peel color and browning indices increased while, pulp firmness, titratable acidity (TA), pH and membrane stability index (MSI) decreased during shelf life. Total soluble solid (TSS) concentration increased up to day five then remained stable whereas, vitamin C increased ranged from 5.8 to 8.2 mg 100g-1 fresh weight (FW) during the first two days and then decreased. Total phenols concentration in both peel and pulp increased ranged from 0.19 to 1.64 gkg-1 and 0.17 to 0.59 gkg-1 FW, respectively during shelf life. Total flavonoids firstly increased, remained stable until day five then, decreased in both peel and pulp. It ranged from 0.05 to 0.21 gkg-1 FW and 0.03 to 0.19 gkg-1 FW in peel and pulp, respectively. Both total phenols and flavonoids concentrations were higher in peel than pulp. FRSC in peel remained stable until day five then, sharply decreased (higher DPPH IC50 values) and ranged from 3.83 to 19.43 IC50 values. While, in pulp it decreased (higher DPPH IC50 values) during shelf life and ranged from 4.1 to 13.3 IC50 values. Polyphenoloxidase (PPO), peroxidase (POD), polygalacturornase (PG), xylanase and ?-amylase activities in peel and pulp greatly varied during shelf life.

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Elsharkawy, Mohamed Shafey, Ying Chen, Ranran Liu, Xiaodong Tan, Wei Li, Ibrahim El-Wardany, Dongqin Zhao, Maiqing Zheng, Jie Wen, and Guiping Zhao. "Paternal Dietary Methionine Supplementation Improves Carcass Traits and Meat Quality of Chicken Progeny." Animals 11, no. 2 (January 28, 2021): 325. http://dx.doi.org/10.3390/ani11020325.

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The effects that maternal dietary methionine have on progeny have been reported on broilers. However, the paternal effects are not known, so the current study was conducted to explore the influences of paternal dietary methionine (Met) have on progeny carcass traits, meat quality, and related gene expressions. A total of 192 hens and 24 roosters from Ross parent stock at 36 weeks of age were selected. From week 37 to 46, the roosters were allocated to two groups with three replicates of 4 cocks each, (control, 0.28% Met), and methionine group (MET group, 0.28% Met + 0.1% coated Met). The results revealed that, although the heavier live body weight in progeny at day 49 of control group compared to MET group (p < 0.05), the relative eviscerated yield and relative thigh muscle yield were higher in MET group (p < 0.05); but the relative abdominal fat was lower (p < 0.05). In thigh and breast muscles, a positive response of pH24 h value, shear force (g) and drip loss (%) were observed in MET group (p < 0.05). The lightness (L) and redness (a) were increased (p < 0.05) in breast muscles of MET group, while only the redness (a*24 h) and yellowness (b*24 h) were increased (p < 0.05) in thigh muscles of MET group. The gender has a significant (p < 0.05) effect on carcass traits and muscle redness (a*), where these traits improved in males, and no interaction between treatments and gender were observed for these results. The expression levels of PRKAG2 and PRDX4 supported the changes in muscle pH, with these up-regulated in thigh and breast muscles of MET group, the PPP1R3A gene supported the changes in pH value being down-regulated (p < 0.01) in these same muscles. The BCO1 gene expression was consistent with the changes in meat color and was up-regulated (p < 0.01) in thigh muscles of MET group, consistent with the changes in b* color values. Finally, it was concluded that the supplementation of 0.1% Met to rooster diets could improve carcass characteristics and meat quality of progeny.

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Guo, Fangjian, Douglas R. Moellering, and W. Timothy Garvey. "Use of HbA1c for Diagnoses of Diabetes and Prediabetes: Comparison with Diagnoses Based on Fasting and 2-Hr Glucose Values and Effects of Gender, Race, and Age." Metabolic Syndrome and Related Disorders 12, no. 5 (June 2014): 258–68. http://dx.doi.org/10.1089/met.2013.0128.

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Jemima Beryl Mohankumar, Bhavani S, and Sowmiya V. "A cross-sectional study on the physical activity of selected elderly diabetics." World Journal of Biology Pharmacy and Health Sciences 6, no. 1 (April 30, 2021): 039–48. http://dx.doi.org/10.30574/wjbphs.2021.6.1.0037.

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Regular exercise may prevent or delay the development of Type 2 Diabetes Mellitus (T2DM). In addition to moderate- to vigorous-intensity exercise, daily physical activity is also important for the prevention and management of T2D. Elderly diabetics (50-70 years) were selected from the PSG Hospitals - a multi-specialty hospital. A Diabetes Self-Management Questionnaire (DSMQ) was developed to be locally relevant. The validity and reliability was checked before administration of the questionnaire. Data on glycemic control, energy expenditure, and physical activity (MET) were recorded. Physical activity from age 50-60 & 60-70 years were similar as indicated by the 24hr physical activity pattern and MET values. We observed a progression of the metabolic disorder with age as shown by HbA1c values Physical activity and exercise recommendations, therefore, should be tailored to meet the specific needs of each individual.

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Zhang, Shuang-Yi, Guo-Xu Zhao, Shi-Kun Suo, Yu-Mei Wang, Chang-Feng Chi, and Bin Wang. "Purification, Identification, Activity Evaluation, and Stability of Antioxidant Peptides from Alcalase Hydrolysate of Antarctic Krill (Euphausia superba) Proteins." Marine Drugs 19, no. 6 (June 17, 2021): 347. http://dx.doi.org/10.3390/md19060347.

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For utilizing the largest source of marine proteins, Antarctic krill (Euphausia superba) proteins were defatted and hydrolyzed separately using pepsin, alcalase, papain, trypsin, and netrase, and alcalase hydrolysate (EPAH) showed the highest DPPH radical (DPPH·) and hydroxyl radical (HO·) scavenging activity among five hydrolysates. Using ultrafiltration and chromatography methods, fifteen antioxidant peptides were purified from EPAH and identified as Asn-Gln-Met (NQM), Trp-Phe-Pro-Met (WFPM), Gln-Asn-Pro-Thr (QNPT), Tyr-Met-Asn-Phe (YMNF), Ser-Gly-Pro-Ala (SGPA), Ser-Leu-Pro-Tyr (SLPY), Gln-Tyr-Pro-Pro-Met-Gln-Tyr (QYPPMQY), Glu-Tyr-Glu-Ala (EYEA), Asn-Trp-Asp-Asp-Met-Arg-Ile-Val-Ala-Val (NWDDMRIVAV), Trp-Asp-Asp-Met-Glu-Arg-Leu-Val-Met-Ile (WDDMERLVMI), Asn-Trp-Asp-Asp-Met-Glu-Pro-Ser-Phe (NWD-DMEPSF), Asn-Gly-Pro-Asp-Pro-Arg-Pro-Ser-Gln-Gln (NGPDPRPSQQ), Ala-Phe-Leu-Trp-Asn (AFLWA), Asn-Val-Pro-Asp-Met (NVPDM), and Thr-Phe-Pro-Ile-Tyr-Asp-Tyr-Pro-Gln (TFPIYDPQ), respectively, using a protein sequencer and ESI/MS. Among fifteen antioxidant peptides, SLPY, QYPPMQY and EYEA showed the highest scavenging activities on DPPH· (EC50 values of 1.18 ± 0.036, 1.547 ± 0.150, and 1.372 ± 0.274 mg/mL, respectively), HO· (EC50 values of 0.826 ± 0.027, 1.022 ± 0.058, and 0.946 ± 0.011 mg/mL, respectively), and superoxide anion radical (EC50 values of 0.789 ± 0.079, 0.913 ± 0.007, and 0.793 ± 0.056 mg/mL, respectively). Moreover, SLPY, QYPPMQY and EYEA showed strong reducing power, protective capability against H2O2-damaged plasmid DNA, and lipid peroxidation inhibition ability. Furthermore, SLPY, QYPPMQY, and EYEA had high stability under temperatures lower than 80 °C, pH values ranged from 6–8, and simulated GI digestion for 180 min. The results showed that fifteen antioxidant peptides from alcalase hydrolysate of Antarctic krill proteins, especially SLPY, QYPPMQY and EYEA, might serve as effective antioxidant agents applied in food and health products.

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CONIX, STIJN. "Values, regulation, and species delimitation." Zootaxa 4415, no. 2 (April 30, 2018): 390. http://dx.doi.org/10.11646/zootaxa.4415.2.9.

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Garnett and Christidis (2017) [hereafter GC] recently proposed that the International Union of the Biological Sciences should centrally regulate the taxonomy of complex organisms. Their proposal was met with much criticism (e.g. Hołyński 2017; Thomson et al., 2018), and perhaps most extensively from Raposo et al. (2017) in this journal. The main target of this criticism was GC’s call to, first, “restrict the freedom of taxonomic action”, and, second, to let social, political and conservation values weigh in on species classification. Some commentators even went as far as to draw a comparison with the infamous Lysenko-case of state-controlled and heavily restricted science (Raposo et al. 2017, 181; Hołyński 2017, 12). This comment will argue, without thereby endorsing GC’s position, that these two aspects of their views need not be as threatening as this comparison suggests, and indeed are very reasonable.

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Ázara, Helouane, Paulo Farinatti, Adrian Midgley, Fabrício Vasconcellos, Patrícia Vigário, and Felipe Cunha. "Standardized MET Value Underestimates the Energy Cost of Treadmill Running in Men." International Journal of Sports Medicine 38, no. 12 (September 26, 2017): 890–96. http://dx.doi.org/10.1055/s-0043-115739.

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AbstractThe main purpose of the present study was to compare the reference metabolic equivalent (MET) value and observed resting oxygen uptake (VO2) for defining cardiorespiratory fitness (VO2max) and characterizing the energy cost of treadmill running. A heterogeneous cohort of 114 healthy men volunteered to participate. In Part 1 of the study, 114 men [mean±SD, age: 24±5 years; height: 177.1±7.9 cm; body mass: 75.0±10.0 kg] visited the laboratory twice for assessment of resting and maximal VO2 values to compare the reference MET value vs. observed resting VO2 and to investigate the association between resting VO2 and VO2max. In Part 2, 14 of the 114 men visited the laboratory once more to perform a 30-min bout of running at 8.0 km∙h−1/8.3 METs. The mean observed resting VO2 of 3.26 mL·kg−1·min−1 was lower than the reference MET value of 3.5 mL·kg−1·min−1 (P<0.001). Resting and maximal VO2 values relative to total body mass and fat-free mass were positively correlated (R=0.71 and 0.60, respectively; P<0.001). The maximal MET and energy cost of treadmill running were consequently underestimated when calculated using the reference MET value only for those with low VO2max (P=0.005 to P<0.001). In conclusion, the reference MET value considerably overestimated observed resting VO2 in men with low VO2max, resulting in underestimations of the maximal MET, exercise intensity prescription, and the energy cost of running.

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Yamaguchi, Shigeru, Tohru Shiga, Kenji Hirata, Shunsuke Terasaka, Hiroyuki Kobayashi, Eku Shimosegawa, Naoya Kagawa, et al. "ACT-07 Clinical Trials of 11C-Methionine PET for brain tumors." Neuro-Oncology Advances 2, Supplement_3 (November 1, 2020): ii8. http://dx.doi.org/10.1093/noajnl/vdaa143.035.

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Abstract Background: Although 11C-Methionine (MET) PET has widely used, 11C-MET tracer has not been approved in Japan. We conducted multi-center prospective clinical trials using MET for drug approval in diagnosis of brain tumors[Methods] Two trials using 11C-MET PET were performed in Hokkaido University, Osaka University and Fukushima Medical University; 1) Diagnostic accuracy in differentiating tumor recurrence from radiation injury after radiotherapy in brain tumors, 2) The diagnostic efficacy in newly-diagnosed gliomas. 1) The patients with suspected brain tumor recurrence underwent MET and 18F-Fluorodeoxyglucose (FDG) PET. When the target lesion showed MET and/or FDG uptake, the patients underwent target resection for pathological confirmation. Positive prediction values of each tracer uptake were assessed as primary outcome measure, and the sensitivities and specificities of each PET exams were also assessed. 2) The patients with suspected gliomas underwent MET PET. Tissue samplings were performed from MET uptake lesions without contrast-enhancement on MRI in each patient, and evaluated the existence of tumor cells. Diagnostic additional values of MET PET on contrast-enhanced MRI was also investigated. Safety of MET PET was also assessed in each trial.[Result] 1) 57 cases were investigated. 38 cases underwent surgery and 32 cases (84%) were confirmed tumor recurrence histopathologically. MET and FDG uptake in 32 recurrence cases were 100% and 50%, respectively. Sensitivities and specificities of tumor recurrence were 84% and 89% in MET, and 100% and 56% in FDG. 2) 53 glioma cases were enrolled. Viable tumor cells were proven in 98% in MET uptake lesion without contrast-enhancement. In 42 out of 53 cases (78%), MET PET depicted tumor area beyond the contrast-enhancement area on MRI. No severe adverse events were observed in both trials. [Conclusions] MET PET were effective in diagnosis of brain tumors, and safety of MET was demonstrated.

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Giustra, Martina. "141 Haussmann égre nyíló tető." Metszet 12, no. 1 (2021): 22–27. http://dx.doi.org/10.33268/met.2021.1.2.

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Restoration and refurbishment taking place in a historical district of Paris calls for a contemporary reworking of existing values. The mansard roof form considered to be the norm in this area usually results in a single or double floor rooftop development of dark spaces under a slate roof. To replace the material purely with glazing has two effects: firstly the traditional expectation is met, secondly a bright and vibrant interior is created. The latter being more inline with current expectations for quality of light, space and therefore wellbeing of its inhabitants. Proof that often the choice of materials, instead of bold architectural statements, can result in a quality development without need for controversy.

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Melczer, Csaba, László Melczer, Ilona Goják, Attila Kónyi, Sándor Szabados, L. Bence Raposa, András Oláh, and Pongrác Ács. "Reszinkronizációs készülékkel élő betegek fizikai aktivitásának összehasonlító vizsgálata telemetriás adatok alapján." Orvosi Hetilap 158, no. 19 (May 2017): 748–53. http://dx.doi.org/10.1556/650.2017.30720.

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Abstract: Introduction: The effect of regular physical activity on health is widely recognized, but several studies have shown its key importance for heart patients. Aim: The present study aimed to define the PA % values, and to convert them into metabolic equivalent values (MET), which describes oxygen consumption during physical activity. Method: A total of seventeen patients with heart disease; 3 females and 14 males; age: 57.35 yrs ± 9.54; body mass 98.71 ± 9.89 kg; average BMI 36.69 ± 3.67 were recruited into the study. The measured values from Cardiac Resynchronisation Therapy devices and outer accelerometers (ActiGraph GT3X+) were studied over a 7-day time period. Using the two sets of values describing physical performance, linear regression was calculated providing a mathematical equation, thus, the Physical Activity values in percentage were converted into MET values. Results: During the 6-minute walk test the patients achieved an average of 416.6 ± 48.2 m. During 6MWT the measured values averaged at 1.85 ± 0.18 MET’s, and MET values averaged at 1.12 ± 0.06 per week. It clearly shows that this test is a challenge for the patients compared to their daily regular physical activity levels. Conclusion: With our method, based on the values received from the physical activity sensor implanted into the resynchronisation devices, changes in patients’ health status could be monitored telemetrically with the assistance from the implanted electronic device. Orv Hetil. 2017; 158(17): 748–753.

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Massidda, Myosotis, Lucia Cugusi, Maurizio Ibba, Iosto Tradori, and Carla M. Calò. "Energy Expenditure during Competitive Latin American Dancing Simulation." Medical Problems of Performing Artists 26, no. 4 (December 1, 2011): 206–10. http://dx.doi.org/10.21091/mppa.2011.4033.

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The aims of this study were to estimate the energy expenditure (EE) and the intensity of physical activity (PA) during a competitive simulation of Latin American dancing and to evaluate the differences in PA and EE values between the sexes, between different dance types, and between the various phases of the competition. METHODS: Ten Italian dancers (five couples, 5 males and 5 females) competing in Latin American dancing at the international level were examined in this study. The EE (kcal) was measured during the semifinal and final phases of the competition using the SenseWear Pro Armband (SWA). Paired-sample t-tests were used to determine differences in the metabolic equivalent (MET) and EE values between the semifinal and final phases and between each dance. One-way analysis of variance was used to analyze the differences in the MET and EE values between the sexes. RESULTS: The intensity of PA during the dance sequence ranged from moderate (3 to 6 METs) to vigorous (6 to 9 METs). The male dancers had higher EE values than the female dancers during all phases of the simulation. Similar MET values were observed in both sexes. The PA intensity during the finals phase was vigorous for 56% of the time of dance. Of all the dance styles, the rumba had the lowest MET and EE values. CONCLUSION: Our results demonstrate that competitive Latin American dancing is a heavy exercise and suggest that monitoring variables during normal training can improve training protocols and the dancers’ fitness levels.

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Jacob, R. H., M. F. D'Antuono, G. M. Smith, D. W. Pethick, and R. D. Warner. "Effect of lamb age and electrical stimulation on the colour stability of fresh lamb meat." Australian Journal of Agricultural Research 58, no. 4 (2007): 374. http://dx.doi.org/10.1071/ar06126.

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The aim of this experiment was to compare the effects of electrical stimulation and lamb age on the retail colour stability of lamb meat. Poll Dorset Merino crossbred lambs that were 5 months (‘suckers’, SU) and 12 months (‘carryovers’, CO) finished on the same green annual pasture were slaughtered at a commercial abattoir. Half of the carcasses in each age group (10) were either electrically stimulated (ES) or not stimulated (NES) post-dressing with a commercial high voltage electrical stimulation system. Luminescence (L), hue angle (indication of redness), chroma (intensity), and oxy/met (a measure of browning) values were measured at 0 h (0 days), 21 h (0.86 days), 93 h (3.88 days), and 166 h (6.91 days) after meat had been cut 1 day after slaughter, over wrapped, and put under simulated retail display conditions. Three muscles, m. longissimus thoracis et lumborum (LL), m. gluteus medias (GM), and m. rectus femoris (RF), were measured in this way. A linear mixed model was used to fit a repeated-measurements model to the light measurements of L, hue angle, chroma, and oxy/met. Oxy/met rate of change was compared by fitting splines to predict the time required for oxy/met to reach an arbitrary benchmark value of 3. Colour and rate of colour change during display were affected by both age class and electrical stimulation but these effects depended on the muscle. The LL was the darkest (lowest L) and reddest (lowest hue angle), whilst RF was the most stable in colour (lowest rate of change for oxy/met) of the 3 muscles tested. Age class had a greater effect on oxy/met rate of change for the LL and GM compared with RF. Oxy/met of LL changed more rapidly for CO than SU lambs. ES increased the time for oxy/met to reach 3 in RF and GM for SU only but did so for both age groups in LL. ES decreased this time in RF and GM for CO. CO meat contained a higher concentration of myoglobin than SU meat. Negative effects of electrical stimulation on colour stability are more likely to occur in older lambs and in the GM and RF rather than in the LL.

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Swartz, Michael F., Pooja Makhija, Jeffrey Rubenstein, Kelly F. Henrichs, Karen S. Powers, Hong Yue Wang, Bartholomew V. Simon, George M. Alfieris, Neil Blumberg, and Jill M. Cholette. "Met-Hemoglobin Is a Biomarker for Poor Oxygen Delivery in Infants Following Surgical Palliation." World Journal for Pediatric and Congenital Heart Surgery 10, no. 4 (May 29, 2019): 485–91. http://dx.doi.org/10.1177/2150135119852327.

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Background:Infants with cyanotic congenital heart disease demonstrate wide fluctuations in hemoglobin (Hb), oxygen saturation, and cardiac output following palliation. Methemoglobin (Met-Hb), the product of Hb oxidation, may represent a compensatory mechanism during hypoxia and may be utilized as a biomarker.Methods:Arterial and venous Met-Hb levels were obtained from infants requiring palliation. The primary outcome was to describe the relationship between Met-Hb and other indices of tissue oxygenation (venous saturation, estimated arteriovenous oxygen difference [Est AV-Diff], and lactate). Secondary outcomes were to determine the impact of elevated Met-Hb levels ≥1.0% and the effect of red blood cell (RBC) transfusion on Met-Hb levels.Results:Fifty infants and 465 Met-Hb values were studied. Venous Met-Hb levels were significantly higher than arterial levels (venous: 0.84% ± 0.36% vs arterial: 0.45% ± 0.18%; P < .001). Venous Met-Hb demonstrated a significant inverse relationship with venous oxygen saturation ( R = −0.6; P < .001) and Hb ( R = −0.3, P < .001) and a direct relationship with the Est AV-Diff ( R = 0.3, P < .001). A total of 129 (29.6%) venous Met-Hb values were elevated (≥1.0%) and were associated with significantly lower Hb and venous saturation levels and higher Est AV-Diff and lactate levels. Methemoglobin levels decreased significantly following 65 RBC transfusions (0.94 ± 0.40 vs 0.77 ± 0.34; P < .001). Linear mixed models demonstrated that higher venous Met-Hb levels were associated with lower measures of tissue oxygenation and not related to any preoperative clinical differences.Conclusion:Methemoglobin may be a clinically useful marker of tissue oxygenation in infants following surgical palliation.

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Erturhan, Sakip, Omer Bayrak, Ahmet Mete, Ilker Seckiner, Gokhan Urgun, and Kemal Sarica. "Can the Hounsfield unit predict the success of medically expulsive therapy." Canadian Urological Association Journal 7, no. 11-12 (November 8, 2013): 677. http://dx.doi.org/10.5489/cuaj.352.

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Background: We investigate the predictability of medical expulsive therapy (MET) success with alpha blockers based on Hounsfield unit (HU) values and Hounsfield density (HD) values measured by computed tomography (CT) for distal ureteral stones.Methods: Between July 2011 and May 2012, 44 patients (19 female and 25 male) with 5- to 10-mm stones in the distal ureters were included in this randomized prospective study. Non-contrast CT examinations were performed in these patients. HU and HD values of stones were calculated. Doxazosine, 4 mg/day orally, was administered as a single dose to all patients for MET.Results: Patients were divided into 2 groups. Group 1 included 18 patients (43.9%) with dropped stones with MET. Group 2 included 23 patients (56.1%) with no stone passage with MET. In Group 1,the mean stone size was 7.7 mm, the mean HU was 507, and the HD was 53.04/mm. In Group 2, the mean stone size was 8.25 mm, the mean HU was 625, and the mean HD was 61.54/mm. The HU and HD values in Group 2 were higher than in Group 1. However, there was no statistically significant difference (p = 0.85 and 0.93 for HU and HD, respectively).Interpretation: We found that HU and HD values cannot be used to predict the chances of success for MET. Although the sample size is appropriate for the study, further comparative studies involving more patients are warranted.

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He, Hua-Jun, Biswajit Das, Megan H. Cleveland, Li Chen, Corinne E. Camalier, Liang-Chun Liu, Kara L. Norman, et al. "Development and interlaboratory evaluation of a NIST Reference Material RM 8366 for EGFR and MET gene copy number measurements." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 8 (July 26, 2019): 1142–52. http://dx.doi.org/10.1515/cclm-2018-1306.

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Abstract Background The National Institute of Standards and Technology (NIST) Reference Material RM 8366 was developed to improve the quality of gene copy measurements of EGFR (epidermal growth factor receptor) and MET (proto-oncogene, receptor tyrosine kinase), important targets for cancer diagnostics and treatment. The reference material is composed of genomic DNA prepared from six human cancer cell lines with different levels of amplification of the target genes. Methods The reference values for the ratios of the EGFR and MET gene copy numbers to the copy numbers of reference genes were measured using digital PCR. The digital PCR measurements were confirmed by two additional laboratories. The samples were also characterized using Next Generation Sequencing (NGS) methods including whole genome sequencing (WGS) at three levels of coverage (approximately 1 ×, 5 × and greater than 30 ×), whole exome sequencing (WES), and two different pan-cancer gene panels. The WES data were analyzed using three different bioinformatic algorithms. Results The certified values (digital PCR) for EGFR and MET were in good agreement (within 20%) with the values obtained from the different NGS methods and algorithms for five of the six components; one component had lower NGS values. Conclusions This study shows that NIST RM 8366 is a valuable reference material to evaluate the performance of assays that assess EGFR and MET gene copy number measurements.

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Ying, Li, Xihe Zhu, Justin Haegele, and Yang Wen. "Movement in High School: Proportion of Chinese Adolescents Meeting 24-Hour Movement Guidelines." International Journal of Environmental Research and Public Health 17, no. 7 (April 1, 2020): 2395. http://dx.doi.org/10.3390/ijerph17072395.

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The purposes of this study were (a) to examine the proportions of adolescents in China who partially or fully meet three 24-h movement guidelines on physical activity, screen-time, and sleep duration and (b) to examine whether there were gender differences in the proportion of boys and girls meeting these guidelines. The sample was made up of high school adolescents from an eastern province of China (N = 1338). The participants completed a self-reported survey on demographic variables and weekly health behaviors including physical activity, screen-time, and sleep duration. A frequency analysis was conducted to summarize the number of 24-h movement guidelines met of the total sample and by gender; chi-squared tests were used to examine the gender differences in the proportion of students meeting different guidelines, independently and jointly. A high proportion of adolescents did not meet physical activity (97.2%, 95% CI = 96.2–98.0%), or sleep (92.1%, 95% CI = 90.6–93.5%) guidelines, but met screen-time (93.6%, 95% CI = 92.4–94.7%) guidelines. Overall, only 0.3% (95%CI = 0.1–0.6%) of the sample met all three guidelines, 8.8% (95%CI = 7.5–10.2%) met two, 85.8%% (95%CI = 84.0–87.4%) met one, and 5.1% (95%CI = 4.0–6.4%) met none. There was no statistically significant percentage difference between female and male participants in meeting physical activity, screen-time viewing, or sleep duration guidelines, independently or jointly (p values > 0.05). These figures of participants meeting all three guidelines or physical activity and sleep independently are much lower than many estimates in prior research internationally. Considerations to improve adherence to physical activity and sleep guidelines are critical in this population.

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RABKIN, RALPH, FERNANDO FERVENZA, TANNY TSAO, RICHARD SIBLEY, MICHAEL FRIEDLAENDER, FAY HSU, CHARLES LASSMAN, MICHAEL HAUSMANN, PHIL HUIE, and RALPH H. SCHWALL. "Hepatocyte Growth Factor Receptor in Acute Tubular Necrosis." Journal of the American Society of Nephrology 12, no. 3 (March 2001): 531–40. http://dx.doi.org/10.1681/asn.v123531.

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Abstract. In acute tubular necrosis, there are early transient increases in circulating and local bioactive hepatocyte growth factor (HGF) levels and renal HGF receptor (c-MET) gene expression. It has therefore been suggested that endogenous HGF may play a role in initiating renal repair. To test this hypothesis, changes in the levels, activity, and anatomic distribution of c-MET protein were characterized in relation to the onset and localization of DNA synthesis in kidneys of rats with ischemia-induced acute tubular necrosis. Whole-kidney c-MET protein levels were significantly increased in the injured kidneys 12 h after injury and rose to a maximum after 1 d, exceeding the control values by sevenfold. Eight days after injury, c-MET levels, although decreasing, were still elevated above control values. An increase in the levels of activated c-MET, i.e., tyrosine-phosphorylated c-MET, was also evident as early as 12 h after injury. Histologic analyses demonstrated that the increase in c-MET immunoreactivity was most marked in the most severely damaged nephron segments in the outer medulla. In injured proximal tubules, the receptor was redistributed from an apical location to an intracellular location. DNA synthesis was increased in the injured kidneys, especially in the outer medulla, where the increase in c-MET protein levels was most prominent. The increase in DNA synthesis was first detected 12 h after the initial increase in activated c-MET levels. It is concluded that the early increases in the levels of c-MET protein and activated receptor support the hypothesis that HGF participates in the initiation of renal regeneration. In addition, the persistent elevation of c-Met protein levels suggests that prolonged and even late treatment with HGF may be of therapeutic value

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Morales-Lozano, Maria I., Oliver Viering, Samuel Samnick, Paula Rodriguez-Otero, Andreas K. Buck, Maria Marcos-Jubilar, Leo Rasche, et al. "18F-FDG and 11C-Methionine PET/CT in Newly Diagnosed Multiple Myeloma Patients: Comparison of Volume-Based PET Biomarkers." Cancers 12, no. 4 (April 23, 2020): 1042. http://dx.doi.org/10.3390/cancers12041042.

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11C-methionine (11C-MET) is a new positron emission tomography (PET) tracer for the assessment of disease activity in multiple myeloma (MM) patients, with preliminary data suggesting higher sensitivity and specificity than 18F-fluorodeoxyglucose (18F-FDG). However, the value of tumor burden biomarkers has yet to be investigated. Our goals were to corroborate the superiority of 11C-MET for MM staging and to compare its suitability for the assessment of metabolic tumor burden biomarkers in comparison to 18F-FDG. Twenty-two patients with newly diagnosed, treatment-naïve symptomatic MM who had undergone 11C-MET and 18F-FDG PET/CT were evaluated. Standardized uptake values (SUV) were determined and compared with total metabolic tumor volume (TMTV) for both tracers: total lesion glycolysis (TLG) and total lesion 11C-MET uptake (TLMU). PET-derived values were compared to Revised International Staging System (R-ISS), cytogenetic, and serologic MM markers such as M component, beta 2 microglobulin (B2M), serum free light chains (FLC), albumin, and lactate dehydrogenase (LDH). In 11 patients (50%), 11C-MET detected more focal lesions (FL) than FDG (p < 0.01). SUVmax, SUVmean, SUVpeak, TMTV, and TLMU were also significantly higher in 11C-MET than in 18F-FDG (p < 0.05, respectively). 11C-MET PET biomarkers had a better correlation with tumor burden (bone marrow plasma cell infiltration, M component; p < 0.05 versus p = n.s. respectively). This pilot study suggests that 11C-MET PET/CT is a more sensitive marker for the assessment of myeloma tumor burden than 18F-FDG. Its implications for prognosis evaluation need further investigation.

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Taris, Ruben, Jan A. Feij, and Annelies E. M. van Vianen. "Met expectations and supplies–values fit of Dutch young adults as determinants of work outcomes." International Journal of Human Resource Management 16, no. 3 (March 2005): 366–82. http://dx.doi.org/10.1080/0958519042000339552.

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Wendt, Michał, and Małgorzata Waszak. "Evaluation of the Combination of Muscle Energy Technique and Trigger Point Therapy in Asymptomatic Individuals with a Latent Trigger Point." International Journal of Environmental Research and Public Health 17, no. 22 (November 14, 2020): 8430. http://dx.doi.org/10.3390/ijerph17228430.

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(1) Background: The aim of the study was to determine the effect of the combination therapy of Muscle Energy Technique (MET) and Trigger Point Therapy (TPT) on the angular values of the range of movements of the cervical spine and on the pressure pain threshold (PPT) of the trapezius muscle in asymptomatic individuals. METHODS: The study involved 60 right-handed, asymptomatic students with a latent trigger point in the upper trapezius muscle. All qualified volunteers practiced amateur symmetrical sports. The study used a tensometric electrogoniometer (cervical spine movement values) and an algometer (pressure pain threshold (PPT) of upper trapezius). Randomly (sampling frame), volunteers were assigned to three different research groups (MET + TPT, MET and TPT). All participants received only one therapeutic intervention. Measurements were taken in three time-intervals (pre, post and follow-up the next day after therapy). (2) Results: One-time combined therapy (MET + TPT) significantly increases the range of motion occurring in all planes of the cervical spine. One-time treatments of single MET and single TPT therapy selectively affect the mobility of the cervical spine. The value of the PPT significantly increased immediately after all therapies, but only on the right trapezius muscle, while on the left side only after the therapy combining MET with TPT. (3) Conclusion: The MET + TPT method proved to be the most effective, as it caused changes in all examined goniometric and subjective parameters.

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Arvidsson, Daniel, Jonatan Fridolfsson, Christoph Buck, Örjan Ekblom, Elin Ekblom-Bak, Lauren Lissner, Monica Hunsberger, and Mats Börjesson. "Reexamination of Accelerometer Calibration with Energy Expenditure as Criterion: VO2net Instead of MET for Age-Equivalent Physical Activity Intensity." Sensors 19, no. 15 (August 1, 2019): 3377. http://dx.doi.org/10.3390/s19153377.

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Accelerometer calibration for physical activity (PA) intensity is commonly performed using Metabolic Equivalent of Task (MET) as criterion. However, MET is not an age-equivalent measure of PA intensity, which limits the use of MET-calibrated accelerometers for age-related PA investigations. We investigated calibration using VO2net (VO2gross − VO2stand; mL⋅min−1⋅kg−1) as criterion compared to MET (VO2gross/VO2rest) and the effect on assessment of free-living PA in children, adolescents and adults. Oxygen consumption and hip/thigh accelerometer data were collected during rest, stand and treadmill walk and run. Equivalent speed (Speedeq) was used as indicator of the absolute speed (Speedabs) performed with the same effort in individuals of different body size/age. The results showed that VO2net was higher in younger age-groups for Speedabs, but was similar in the three age-groups for Speedeq. MET was lower in younger age-groups for both Speedabs and Speedeq. The same VO2net-values respective MET-values were applied to all age-groups to develop accelerometer PA intensity cut-points. Free-living moderate-and-vigorous PA was 216, 115, 74 and 71 min/d in children, adolescents, younger and older adults with VO2net-calibration, but 140, 83, 74 and 41 min/d with MET-calibration, respectively. In conclusion, VO2net calibration of accelerometers may provide age-equivalent measures of PA intensity/effort for more accurate age-related investigations of PA in epidemiological research.

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Donnachie, Craig, Kate Hunt, Nanette Mutrie, Jason M. R. Gill, and Paul Kelly. "Responsiveness of Device-Based and Self-Report Measures of Physical Activity to Detect Behavior Change in Men Taking Part in the Football Fans in Training (FFIT) Program." Journal for the Measurement of Physical Behaviour 3, no. 1 (March 1, 2020): 67–77. http://dx.doi.org/10.1123/jmpb.2019-0018.

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The capacity of physical activity (PA) measures to detect changes in PA within interventions is crucial. This is the first study to examine the responsiveness of activPAL3™ and the International Physical Activity Questionnaire (IPAQ; Short Form) in detecting PA change during a 12-week group-based, men-only weight management program—Football Fans in Training (FFIT). Participants wore an activPAL3™ and completed the IPAQ pre- and post-program (n = 30). Relationships between change scores were assessed by Spearman’s correlations. Mean or median changes in PA were measured using paired samples t-tests and Wilcoxon signed-rank tests. Responsiveness to change was assessed utilizing Standardized Response Mean (SRM). Both device-based and self-report measures demonstrated significant changes pre-post intervention, although these changes were not significantly correlated. The SRM values for changes in activPAL3™ metrics were: 0.54 (for MET-mins/day); 0.53 (for step counts/day); and 0.44 (for MVPA/day), indicating a small to medium responsiveness to change. SRM values for changes in IPAQ scores were: 0.59 (for total PA mins/day); 0.54 (for total MET-mins/day); 0.59 (for walking MET-mins/day); 0.38 (for vigorous MET-mins/day); and 0.38 (for moderate MET-mins/day), revealing a small to medium responsiveness to change. These findings reveal that two commonly used device-based and self-report measures demonstrated responsiveness to changes in PA. While inclusion of both device-based and self-report measures is desirable within interventions it is not always feasible. The results from this study support that self-reported measures can detect PA change within behavioral interventions, although may have a tendency to overestimate changes compared with device-based measures on absolute values, but not standardized response values.

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Journal articles on the topic 'MET values'

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