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1

Karlsson, Torbjörn. Circulation and turn-over of lactate during induced hypocapnic hyperventilation and metabolic alkalosis: An experimental study in the pig. Acta Universitatis Upsaliensis, 1994.

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2

W, Gorrod J., and Wahren John, eds. Nicotine and related alkaloids: Absorption, distribution, metabolism, and excretion. Chapman & Hall, 1993.

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3

Kraml, Marlene Margaretha. Altered alkaloid metabolism in plant cell suspension cultures of Thalictrum rugosum Ait. (Ranunculaceae). National Library of Canada = Bibliothèque nationale du Canada, 1992.

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4

Magnotta, Mary. Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation. Dept. of Biological Sciences, 2007.

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5

Goddijn, Oscar Johannes Maria. Regulation of terpenoid indole alkaloid biosynthesis in Catharanthus roseus: The tryptophan decarboxylase gene. Offsetdrukkerij Haveka BV, 1992.

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6

Waldmann, Carl, Neil Soni, and Andrew Rhodes. Metabolic disorders. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199229581.003.0024.

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Electrolyte disorders 410Hyponatraemia 414Hypernatraemia 416Categorizing metabolic acidoses 418Metabolic acidosis aetiology 420Metabolic alkalosis 422Glycaemic control in the critically ill 426Diabetic ketoacidosis 428Hyperosmolar diabetic emergencies 430Thyroid emergencies: thyroid crisis/thyrotoxic storm 432Thyroid emergencies: myxoedema coma 434Hypoadrenal crisis ...
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7

Halperin, Mitchell L., and Kamel S. Kamel. Approach to the patient with metabolic acidosis or alkalosis. Edited by Robert Unwin. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0035_update_001.

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The pathophysiology, clinical approach, and management of the common causes of metabolic acidosis and alkalosis are discussed. In metabolic acidosis, a quantitative estimate of the extracellular volume (ECFV) is required to determine its content of bicarbonate in a patient with ECFV contraction. Buffering of H+ must occur by the bicarbonate buffer system in muscle to avoid binding to intracellular proteins, this requires low muscle capillary PCO2; acid gain type of metabolic acidosis is detected by the finding of new anions in blood and/or urine. The urine osmolal gap is the best indirect test
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8

Brimioulle, Serge. Pathophysiology, causes, and management of metabolic alkalosis in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0257.

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Metabolic alkalosis occurs in up 51% of abnormal acid-base samples in the hospital. It is characterized by a primary increase in bicarbonate concentration and is always associated with chloride depletion. In critically-ill patients, it is most often generated by diuretic administration, digestive losses, alkali administration, or rapid correction of hypercapnia. Even after all causal factor are removed, it can be maintained by blood volume depletion and potassium depletion. Metabolic alkalosis results in hypercapnia, hypoxaemia, cardiac arrhythmias, altered consciousness, and neuromuscular hyp
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9

Albright, Robert C. Acid-Base and Electrolyte Disorders. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0474.

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The most important principle in understanding disorders of water balance is that sodium balance is determined by the adequacy of the effective circulating volume, while water balance is determined by osmoregulation and the interplay between vasopressin activity, renal concentrating and diluting ability, and thirst. Disorders of sodium balance can be determined only by clinical examination. Orthostatic hypotension implies volume depletion and sodium deficiency. Edema implies volume excess and sodium excess. Potassium is predominantly an intracellular cation. The intracellular balance of potassi
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10

Hatfield, Anthea. Metabolism. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199666041.003.0024.

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This chapter tells you how homeostasis in the body is achieved. Contributing factors such as stress, hormones, and the automatic nervous system are integrated into the discussion in a thoughtful way. The problem of cold postoperative patients is thoroughly referenced to modern investigation. Diabetes, how surgery destabilizes diabetics, and how to use insulin is explained. Malignant hyperthermia, thyroid storm, and acid—base disorders are all problems that can occur in the recovery room and guidelines for the management of these patients are outlined. Hydrogen ions affect haemoglobin and bioch
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11

Turner, Ben, and Imelda Tjia. Electrolyte Disturbance in Pyloric Stenosis. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0002.

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Pyloric stenosis is the most common surgical cause of nonprojectile vomiting in a male infant between 3 and 6 weeks of age. While this condition may result in severe dehydration if not managed promptly, management must be addressed as a medical emergency and not a surgical emergency. Correction of the metabolic alkalosis that affected babies typically present with is paramount prior to surgical repair. The failure of this to occur preoperatively may lead to postoperative complications such as postoperative apnea. This chapter presents a case study of a baby with electrolyte imbalance due to py
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12

Joynt, Gavin M., and Gordon Y. S. Choi. Blood gas analysis in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0072.

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Arterial blood gases allow the assessment of patient oxygenation, ventilation, and acid-base status. Blood gas machines directly measure pH, and the partial pressures of carbon dioxide (PaCO2) and oxygen (PaO2) dissolved in arterial blood. Oxygenation is assessed by measuring PaO2 and arterial blood oxygen saturation (SaO2) in the context of the inspired oxygen and haemoglobin concentration, and the oxyhaemoglobin dissociation curve. Causes of arterial hypoxaemia may often be elucidated by determining the alveolar–arterial oxygen gradient. Ventilation is assessed by measuring the PaCO2 in the
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13

Freely Jr, John J., and Michel Sabbagh. Pyloric Stenosis. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0083.

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Pyloric stenosis is one of the most common surgical conditions affecting neonates and young infants. Hypertrophy of the pyloric muscular layers results in gradual gastric outlet obstruction. Persistent episodic projectile vomiting and dehydration as well as hypochloremic, hypokalemic metabolic alkalosis are cardinal features. Definitive treatment is surgical pyloromyotomy, but it is not a surgical emergency. Emergency medical intervention is often required to correct intravascular volume depletion and electrolyte disturbances. Morbidity and mortality should be limited due to advancements in su
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14

Mashman, Darlene, and Carmen Mays. Idiopathic Hypertrophic Pyloric Stenosis. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0039.

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Idiopathic hypertrophic pyloric stenosis (IHPS) is a common cause of nonbilious, projectile vomiting in the infant. Progressive hypertrophy of the pyloric muscle leads to an obstruction of the gastric outlet. The condition is easily corrected with a pyloromyotomy. Mortality is <0.5% in most specialty centers when hydration and normal electrolyte status is restored prior to surgery, appropriate precautions are taken preoperatively, and the patient is carefully monitored for known postoperative complications. This chapter discusses the related epidemiology and etiology; clinical presentation;
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15

Jubb, Annie, and David Jubb. Secrets of an Alkaline Body: The New Science of Colloidal Biology. North Atlantic Books, 2004.

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16

Houillier, Pascal. Magnesium homeostasis. Edited by Robert Unwin. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0027.

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Magnesium is critically important in the process of energy release. Although most magnesium is stored outside the extracellular fluid compartment, the regulated concentration appears in blood. Urinary magnesium excretion can decrease rapidly to low values when magnesium entry rate into the extracellular fluid volume is low, which has several important implications: cell and bone magnesium do not play a major role in the defence of blood magnesium concentration; while a major role is played by the kidney and especially the renal tubule, which adapts to match the urinary magnesium excretion and
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17

Chung, Woon-Gye. Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig. 1993.

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18

Robinson, Trevor. Biochemistry of Alkaloids. Springer London, Limited, 2013.

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19

Robinson, Trevor. Biochemistry of Alkaloids. Springer London, Limited, 2012.

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20

Alkaloid Biology and Metabolism in Plants. Springer, 2012.

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21

Waller, G. Alkaloid Biology and Metabolism in Plants. Springer London, Limited, 2012.

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22

Waller, G. Alkaloid Biology and Metabolism in Plants. Springer, 2012.

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23

Robinson, Trevor. The Biochemistry of Alkaloids. Springer, 2011.

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24

Hovermale, Jeannette Talbot. Metabolism of pyrrolizidine alkaloids by ruminal microbes. 1998.

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25

Crozier, Alan, Hiroshi Ashihara, and Iziar A. Ludwig. Plant Nucleotide Metabolism: Biosynthesis, Degradation and Alkaloid Formation. Wiley & Sons, Limited, John, 2020.

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26

Crozier, Alan, Hiroshi Ashihara, and Iziar A. Ludwig. Plant Nucleotide Metabolism: Biosynthesis, Degradation, and Alkaloid Formation. Wiley & Sons, Limited, John, 2020.

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27

Crozier, Alan, Hiroshi Ashihara, and Iziar A. Ludwig. Plant Nucleotide Metabolism: Biosynthesis, Degradation, and Alkaloid Formation. Wiley & Sons, Incorporated, John, 2020.

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28

Crozier, Alan, Hiroshi Ashihara, and Iziar A. Ludwig. Plant Nucleotide Metabolism: Biosynthesis, Degradation, and Alkaloid Formation. Wiley & Sons, Incorporated, John, 2020.

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29

Wahren, J., and J. W. Gorrod. Nicotine and Related Alkaloids: Absorption, Distribution, Metabolism and Excretion. Springer, 2012.

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30

Natural Products Phytochemistry Botany And Metabolism Of Alkaloids Phenolics And Terpenes. Springer, 2012.

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31

Ramawat, Kishan Gopal, and Jean-Michel Mérillon. Natural Products Vol. 3: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Springer London, Limited, 2013.

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32

Ramsdell, Howard Scott. Toxicity and in vitro metabolism of Senecio jacobaea pyrrolizidine alkaloids in the rat and mouse. 1985.

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33

The effects of orally ingested sodium bicarbonate on short duration maximal exercise in trained middle distance runners. 1985.

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34

Huan, Jianya. Effects of dietary pyrrolizidine alkaloids on copper and vitamin A metabolism in the chicken and Japanese quail. 1991.

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35

Chemical aspects of biosynthesis. Oxford University Press, 1994.

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