Relevant bibliographies by topics / Metabolic CD34+ cells

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Metabolic CD34+ cells'

Author: Grafiati
Published: 6 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Metabolic CD34+ cells"

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Kochi, Yu, Yoshikane Kikushige, Toshihiro Miyamoto, and Koichi Akashi. "Identification of ASCT1 As a Candidate Molecule Enhancing Antioxidant Activity in Primary Human AML Cells." Blood 128, no. 22 (2016): 1674. http://dx.doi.org/10.1182/blood.v128.22.1674.1674.

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Abstract Introduction: Recent studies have shown that the specific alteration of metabolic pathways are involved in the regulation of function of normal hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) in acute myeloid leukemia (AML). However, little is known about the features of metabolic activity in human HSCs and LSCs. To reveal the metabolic pathway alterations in primary AML cells, we performed the comprehensive metabolome analysis by comparing normal human CD34+ hematopoietic stem/progenitor cells (HSPCs)(n=5) and CD34+ primitive AML cells containing LSCs (n=16) using high
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Fadini, G. P. "Circulating CD34+ cells, metabolic syndrome, and cardiovascular risk." European Heart Journal 27, no. 18 (2006): 2247–55. http://dx.doi.org/10.1093/eurheartj/ehl198.

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Nakasone, Hideki, Misato Kikuchi, Yu Akahoshi, et al. "The Expression of CD83 Would be Increased in CD34-Positive Monocytes Detected in Peripheral Blood Mobilized By G-CSF in Humans." Blood 132, Supplement 1 (2018): 2063. http://dx.doi.org/10.1182/blood-2018-99-112084.

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Abstract [Background] CD34-positive monocytes (CD34+mono) have recently been identified following mobilization by granulocyte-colony stimulating factor (G-CSF), and have been suggested to have a potential to modulate immune functions in animal models. However, the biological feature of CD34+mono in humans still remains unclear. Thus, we explored the difference between CD34+mono, CD34+cells, and monocytes through the analyses of gene expression profiles (GEP). [Methods] CD34+mono (Lin-CD34+CD33+CD14+CD11b+, Figure1), CD34+cells (Lin-CD34+CD33-CD14-CD11b- ), and monocytes (Lin-CD34-CD33+CD14+CD1
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Desterke, Christophe, Estelle Balducci, Xavier Fund, Claire Borie, Annelise Bennaceur-Griscelli, and Ali G. Turhan. "A Novel Metabolic Transcriptome Identified in Myelodysplastic Syndromes (MDS) Correlates with OMS Classification and Poor Prognosis." Blood 132, Supplement 1 (2018): 5495. http://dx.doi.org/10.1182/blood-2018-99-110678.

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Abstract Myelodysplastic syndromes (MDS) are clonal malignancies of the hematopoietic stem cell leading to an ineffective hematopoiesis with a complex and poorly understood pathophysiology combining increased apoptosis and propensity to transformation associated with immune dysregulation. Despite a major improvement of the classification of MDS in terms of diagnosis and prognosis according to OMS recommendations, a significant fraction of MDS remains unclassified. In this study, we wished to determine if the integrative analysis of global MDS transcriptome associated with single cell experimen
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Perrone, Olivia, Tiziana Coppola, James Bartram, Waseem Nasr, Juying Xu, and Marie-Dominique Filippi. "The Effect of SCD-1 Inhibition on Human Hematopoietic Stem Cell Mitochondrial Metabolism, Cell Proliferation, and Differentiation Potential." Blood 142, Supplement 1 (2023): 1308. http://dx.doi.org/10.1182/blood-2023-185260.

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Hematopoietic stem cells (HSC) give rise to all blood lineages and sustain the production of blood cells throughout life. Due to their inherently high regenerative potential, HSC are used in a variety of clinical settings, including bone marrow transplantation (BMT) directly to cure a variety of hematologic and oncologic disorders often with gene therapy. During regeneration, HSC are activated into cycle. For this, HSC undergo drastic mitochondrial and metabolic remodeling to meet the bioenergetic and biosynthetic needs of activated HSC. A growing body of evidence indicates that HSC sustain in
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Poulaki, Aikaterini, Theodora Katsila, Emilia S. Hatziyannis, et al. "Metabolic Reprogramming in Myelodysplastic Syndromes." Blood 144, Supplement 1 (2024): 6694. https://doi.org/10.1182/blood-2024-211216.

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Myelodysplastic syndromes (MDS), lie at the interface of normal differentiation and leukemic transformation, being characterised by polymorphic presentation and elusive pathophysiology. Failure to establish a pathogenic relationship with specific genetic aberrations, along with general paucity in innovative and effective treatment strategies, led us to seek the possible role of a dysregulated metabolism in the disease pathobiology. Plasma and CD34+ progenitors isolated from 19 previously untreated MDS patients (WHO 2022 LB#9, IB1#8, IB2#2 - CD34+ pellet purity 97-99%) and 10 age-sex matched co
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Devaraj, Sridevi, and Ishwarlal Jialal. "Dysfunctional Endothelial Progenitor Cells in Metabolic Syndrome." Experimental Diabetes Research 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/585018.

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The metabolic syndrome (MetS) is highly prevalent and confers an increased risk of diabetes and cardiovascular disease. A key early event in atherosclerosis is endothelial dysfunction. Numerous groups have reported endothelial dysfunction in MetS. However, the measurement of endothelial function is far from optimum. There has been much interest recently in a subtype of progenitor cells, termed endothelial progenitor cells (EPCs), that can circulate, proliferate, and dfferentiate into mature endothelial cells. EPCs can be characterized by the assessment of surface markers, CD34 and vascular end
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Dalloul, Ali H., Claire Patry, Jean Salamero, Bruno Canque, Fernanda Grassi, and Christian Schmitt. "Functional and Phenotypic Analysis of Thymic CD34+CD1a− Progenitor-Derived Dendritic Cells: Predominance of CD1a+ Differentiation Pathway." Journal of Immunology 162, no. 10 (1999): 5821–28. http://dx.doi.org/10.4049/jimmunol.162.10.5821.

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Abstract Whether thymic dendritic cells (DC) are phenotypically and functionally distinct from the monocyte lineage DC is an important question. Human thymic progenitors differentiate into T, NK, and DC. The latter induce clonal deletion of autoreactive thymocytes and therefore might be different from their monocyte-derived counterparts. The cytokines needed for the differentiation of DC from thymic progenitors were also questioned, particularly the need for GM-CSF. We show that various cytokine combinations with or without GM-CSF generated DC from CD34+CD1a− but not from CD34+CD1a+ thymocytes
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Nishida, Yuki, Edward Ayoub, Darah Scruggs, et al. "Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC." Blood 142, Supplement 1 (2023): 583. http://dx.doi.org/10.1182/blood-2023-174938.

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Deregulation of MYC genes occurs in up to 70% of all human cancers and is associated with hallmarks of cancer including mitochondrial and ribosomal biogenesis, cell cycle progression, and metabolic abnormalities. TP53 regulates MYC while MYC suppresses TP53, suggesting counteracting negative feedback loops. Therefore, MYC or its function can be activated when TP53 is not functional. TP53 mutations occur in 30% of relapsed/refractory acute myeloid leukemias (AMLs) patients' survival is dismal, and there are no effective therapies for these patients. Compared to TP53 wild-type (TP53wt), TP53 mut
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Rai, Richa, Foramben Patel, Stella Melana, et al. "Rigosertib in Combination with Azacitidine Impacts Metabolic and Differentiation Pathways in the MDS-L Cell Line." Blood 136, Supplement 1 (2020): 35–36. http://dx.doi.org/10.1182/blood-2020-142908.

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Background Myelodysplastic Syndrome (MDS) is characterized by ineffective clonal hematopoiesis with peripheral blood cytopenias, leading to death from infection or bleeding. Azacitidine (AZA), a hypomethylating agent (HMA) is the standard of care for treatment of MDS patients (pts) with higher-risk MDS [Silverman LR, The Myelodysplastic Syndrome in Cancer Medicine, Editors: R.J. Bast, et al. 2017]. Responses to AZA occur in 50% of pts with significant effects on hematopoiesis ranging from improvement in a single lineage to complete restoration of blood counts and transfusion independence [Silv
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Dissertations / Theses on the topic "Metabolic CD34+ cells"

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Guimarães, Tânia Maria Rocha 1963. "Perfil de expressão de células progenitoras endoteliais circulantes CD45-/ CD34+/KDR+ em mulheres hipertensas na pré-menopausa em comparação com mulheres saudáveis normotensas = Expression profile of circulating endothelial progenitor cells CD45-/ CD34+/KDR+ in hypertensive premenopausal women compared with healthy normotensive women." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317311.

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Orientadores: Cristina Pontes Vicente, Patrícia Muniz Mendes Freire de Moura<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-26T00:13:01Z (GMT). No. of bitstreams: 1 Guimaraes_TaniaMariaRocha_D.pdf: 3499853 bytes, checksum: 2767ae0d1bab61dda96ce4765cd63588 (MD5) Previous issue date: 2014<br>Resumo: As células progenitoras endoteliais (EPCs) estão envolvidas em neovasculogênese e na manutenção da homeostase vascular, sua deficiência pode ter papel na patogênese da hipertensão. Este estudo teve como objetivo analisar o perfi
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Refeyton, Alice. "La survie et les adaptations métaboliques des cellules primitives mésenchymateuses et hématopoïétiques en anoxie et anoxie/aglycémie." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0028.

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Les cellules stromales mésenchymateuses (CStroM) comprennent des cellules souches (CS) multipotentes capables de régénérer des tissus lésés par des agressions de type ischémique. Pourtant, une mortalité élevée des CStroM après transplantation est mise en évidence lors de leur prise de greffe. Par conséquent, explorer les stratégies visant à améliorer la viabilité des greffes cellulaires constitue le défi de la thérapie cellulaire. À cette fin, nous avons effectué des analyses fonctionnelles et métaboliques sur deux types de population différents contenant des CS somatiques : des CStroM et une
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Zancanaro, Krauss Maria Eduarda. "CD4+ T cell metabolism during Trichuris muris infection." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/cd4-t-cell-metabolism-during-trichuris-muris-infection(24eb0cc7-db70-46ea-ba49-e4fe3d5a5d03).html.

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Trichuris trichiura is a gastrointestinal dwelling nematode that infects almost 500 million people worldwide. T. muris occurs naturally in mice and is very closely related the human whipworm, making it a suitable model to dissect the immune response against the parasite. Studies using the Trichuris muris system have identified CD4+ T cells as dictators of the outcome of infection. In wild type mice, infection with a high dose of T. muris eggs leads to resistance and worm expulsion, which are dependent on a Th2 response and the secretion of type 2 cytokines especially interleukin (IL) 13. Chron
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St-Pierre, Jessica. "The role of CD4⁺ Foxp3⁺ naturally-occurring regulatory T cells in the host immune response to Plasmodium chabaudi AS /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111941.

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Naturally-occurring CD4+Foxp3+ regulatory T cells (nTreg) play a central role in maintaining immune self-tolerance as well as modulating immunity towards pathogens. Pathogens may establish chronic infections in immunocompetent hosts by engaging nT reg in order to promote immunosuppression. The goal of the research described here is to test the hypothesis that nTreg modulate protective immunity to malaria, and consequentially affect susceptibility to the parasite. To investigate this question, the functional dynamics of CD4+Foxp3 + nTreg cells were evaluated in mice infected with blood-stage Pl
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Tripmacher, Robert. "Untersuchungen zu Wirkungen einer eingeschränkten Energiesynthese auf Funktionen von humanen Immunzellen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15260.

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Hintergrund: Die Funktion von Immunzellen hängt von einer konstanten und ausreichenden Energieversorgung ab, die über die OXPHOS in den Mitochondrien und die Glykolyse im Zytosol realisiert wird. Die wichtigsten Substrate dafür sind Sauerstoff und Glukose. Fragestellung: Bei schweren Erkrankungen oder in Entzündungsgebieten ist die zelluläre Energieversorgung stark beeinträchtigt, weil in der Mikroumgebung der Zelle Sauerstoff und Nährstoffe inadäquat bereitgestellt werden. Ziel war herauszufinden, ob und wie humane Immunzellen ihre Lebensfähigkeit und funktionellen Aktivitäten unter solchen U
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COMPAGNONE, MIRCO. "ΔNp63 controls hyaluronic acid metabolism and signaling in head and neck squamous cell carcinoma". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/202937.

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La famiglia di p53 comprende i tre fattori di trascrizione p53, p63 e p73. Il capostipite della famiglia, p53, è definito il “guardiano del genoma”, grazie alla sua abilità di arrestare il ciclo cellulare in presenza di danno al DNA, consentendone una adeguata riparazione e, nell’eventualità che tale danno non possa essere riparato, promuovere la morte cellulare per apoptosi. p53, dunque, agisce funzionalmente come un classico soppressore di tumore. Infatti, mutazioni con perdita di funzione colpiscono il gene p53 nel 50% circa dei tumori umani. Dopo circa vent’anni di studi intensivi su p53,
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Bourinet, Manon. "Contribution des cellules innées lymphoïdes NKp46+ et régulation de leurs fonctions par CD44 au cours de la stéatohépatite métabolique." Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6008.

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La maladie hépatique stéatotique associée à un dysfonctionnement métabolique (MASLD) est l'une des principales causes de maladies chroniques du foie avec une prévalence mondiale de 33% en 2022. La MASLD regroupe un spectre de lésions hépatiques allant de la stéatose, (accumulation de lipides dans les hépatocytes) vers la stéatohépatite associée au métabolisme (MASH), caractérisée par une inflammation et une mort hépatocytaire. La MASH est la forme évolutive de la maladie qui peut progresser vers des stades plus sévères comme la fibrose/ cirrhose et le carcinome hépatocellulaire. Des acteurs in
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Divoux, Jordane. "Etude du métabolisme des lymphocytes T CD4+ Foxp3+ régulateurs à l’homéostasie et dans un contexte inflammatoire." Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS075.pdf.

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Les lymphocytes T CD4+ Foxp3+ régulateurs (Treg) participent à la régulation de l’activité du système immunitaire et sont essentiel au maintien de la tolérance immune. Ces cellules sont ainsi bénéfiques lors de pathologies auto-immunes tandis que leur action anti-inflammatoire favorise la croissance tumorale. Comprendre le fonctionnement des Treg constitue donc un axe majeur pour le développement de nouvelles stratégies thérapeutiques applicables à ces deux types de pathologies. Au cours de ce travail, nous nous sommes intéressés au métabolisme des Treg étant donné que les informations disponi
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Vahlas, Zoï. "Régulation métabolique de l'infection des cellules T CD4 par VIH-1 : vers de nouvelles cibles thérapeutiques." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT009.

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La susceptibilité des lymphocytes T CD4 (LT) à l'infection par VIH-1 est régulée par le métabolisme du glucose et de la glutamine. Cependant, les contributions relatives de ces nutriments à l'infection étaient peu connues lorsque j’ai débuté ma thèse. Au cours de mes travaux, j'ai identifié la glutaminolyse comme une voie majeure alimentant la phosphorylation oxydative (OXPHOS) dans les sous-populations de LT activés naïves et mémoires, et j'ai découvert que l'induction de ce réseau métabolique est nécessaire pour une infection optimale par VIH-1. J’ai constaté qu’en condition limitante en glu
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Aroua, Nesrine. "Etude in vivo de la chimiorésistance dans les leucémies aigues myéloïdes humaines." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30369.

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Les leucémies aigües myéloïdes (LAM) sont les leucémies les plus fréquentes chez l'adulte, caractérisée par l'expansion clonale de myéloblastes immatures. Malgré un taux élevé de rémission complète après chimiothérapie conventionnelle d'induction, le pronostic est mauvais dans les LAM à cause de fréquentes rechutes. Les rechutes sont causées par une population leucémique chimiorésistante (CLR), pouvant être enrichies en cellules souches leucémiques quiescentes (CSL). Cependant, ces hypothèses n'ont jamais été testées directement in vivo. Mon travail de thèse a été initialement consacré à valid
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Books on the topic "Metabolic CD34+ cells"

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Workshop on Mechanisms and Specificity of HIV Entry into Host Cells (1989 San Francisco, Calif.). Mechanisms and specificity of HIV entry into host cells. Plenum Press, 1991.

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Düzgünes, Nejat. Mechanisms and Specificity of HIV Entry into Host Cells. Springer London, Limited, 2012.

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Düzgünes, Nejat. Mechanisms and Specificity of HIV Entry into Host Cells. Springer, 2012.

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Book chapters on the topic "Metabolic CD34+ cells"

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Matsumoto, Kengo, Ken-ichi Hirano, Shuichi Nozaki, et al. "Expression of CD36 in Cultured Human Aortic Smooth Muscle Cells (HASMCs)." In Lipoprotein Metabolism and Atherogenesis. Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-68424-4_59.

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Bossi, Paolo, and Erika Stucchi. "Exercise and Nutrition Interventions in Head and Neck Cancer." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23175-9_21.

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AbstractOverall Survival (OS) and late quality of life of patients with locally advanced, HPV-negative Head and Neck Squamous Cell Cancer (HNSCC) are not satisfactory. Nutritional status at the beginning of both surgical and non-surgical treatment with curative intent has been linked to OS and quality of life. Weight loss, body-mass index, functional parameters, and biochemical examinations have been associated with the risk of treatment-related adverse events, mortality, quality of life and outcome. Moreover, there is a strong need for effective preventive approaches that could be implemented
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Sugano, Ryo, Mariko Harada-Shiba, Noriyasu Nishimura, et al. "CD36 Expression in Human Monocytic Leukemia Cell Lines: THP-1 and THP-1 Subtype, Show Different Expressions of Type I and Type II Scavenger Receptors." In Lipoprotein Metabolism and Atherogenesis. Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-68424-4_49.

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Gordon-Smith, E. C., and Emma C. Morris. "Haemopoietic stem cell transplantation." In Oxford Textbook of Medicine, edited by Chris Hatton and Deborah Hay. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0549.

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Haemopoietic stem cells (HSCs) give rise to the blood cell lineages and the cells of the immune system, and their transplantation may be an appropriate part of the management of conditions including (1) malignant haematological disorders (e.g. leukaemia, lymphoma, myeloma); (2) bone marrow failure syndromes (e.g. aplastic anaemia); and (3) congenital disorders—(a) haematological (e.g. Fanconi’s anaemia); (b) immunological—inherited immunodeficiency syndromes; and (c) metabolic (e.g. lysosomal storage diseases). Transplantation of HSCs uses either autologous HSCs (patient’s own stem cells) or a
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Wu, Hongmin, and Xiancai Zhong. "Nrf2 as a therapy target for Th17-dependent autoimmune disease." In The Role of NRF2 Transcription Factor [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1005037.

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Th17 cells are a subset of IL-17-expressing CD4+ T helper cells and play a predominant role in the pathogenesis of autoimmune diseases such as multiple sclerosis and psoriasis. Th17 cells sustain their activation and effector functions primarily through a metabolic profile characterized by high glycolytic and oxidative metabolism. Both glycolysis and OXPHOs can affect cellular redox status, and vice versa. Nrf2, a master regulator of redox homeostasis, plays a pivotal role in oxidative stress regulation and influences immune cell function. This chapter summarizes the recent advances in the und
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A. Rakityanskaya, Irina, Tat’jana S. Ryabova, Anastasija A. Kalashnikova, et al. "Perspective Chapter: The Role of Interferon Gamma in Clinical Medicine." In Interferon - Immune Metabolism [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105476.

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Interferon gamma (IFN-γ) is one of the key factors of both innate and adaptive immune response that promotes differentiation of naive CD4+ cells into effector Th1 T cells producing the main mediators of cellular immunity against viral and intracellular bacterial infections, and specific cytotoxic immunity through the interaction of T cells with antigen-presenting cells and macrophage activation. The clinical importance of IFN-γ includes its medical use to treat and prevent various viral and bacterial infections. IFN-γ has a direct antiviral effect on infected cells, activates local infiltratin
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Masson, Jesse James Ronald, and Clovis Steve Palmer. "Glucose metabolism in CD4 and CD8 T cells." In Molecular Nutrition: Carbohydrates. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-849886-6.00016-1.

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"Construction, analysis and correlation of dose response logistic curves for repurposed drugs anticancer effects on fibrosarcoma in hamsters." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.7.1.

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Logarithmic dose response curves are typically „S“-shaped, monotonic and can be fit to a classical Hill equation. The Hill equation is logistic curve – an extension of the sigmoid functions.Although in vitro (cell lines) anticancer effects of some nononcological pleiotropic drugs, such as metformin and itraconazole are reported, in vivo (experimental animals) and clinical investigations, especially of their combinations, are not yet conducted. The study was conducted on Syrian golden hamsters (10-12 weeks old; weight, ~80 g). The animals were randomized into groups (6 hamsters per group). The
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Gould, Kathleen L. "Cyclin-dependent protein kinases." In Protein Kinase Functions. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637713.003.0010.

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Abstract Cyclin-dependent protein kinases (Cdks) regulate progression through the eukaryotic cell cycle. They are also involved in the regulation of other processes such as gene expression and phosphate metabolism. Cdks are the catalytic subunits of hetero dimeric complexes and they approximate the size of a minimal protein-kinase catalytic domain (∼, 34 kDa). Alone, they lack protein kinase activity. As their name implies, By far the best understood of the Cdks are those that have important roles in cell cycle progression-Cdc2, Cdk2, and Cdk4. Cdks are activated transiently at particular stag
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"Rescue control experiments to regain the knockdown anticancer effects of repurposed drugs on fibrosarcoma in hamsters." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.7.3.

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Literature analysis shows that repurposed non-oncological drugs, such as metformin and disulfiram, act through a lot of same anticancer mechanisms, on the same targets, in the same direction. Also, for majority of these mechanisms, non-oncological drug deoxycholic acid acts in the opposite pro- cancer direction. If the rescuing target/protein is expressed at sufficient level that it can reciprocally modulate the pathway of interest, the rescue experiment provide evidence for underlying mechanism of investigated process. To test whether NF-kB and HIF-1a inhibition underlies the anticancer mecha
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Conference papers on the topic "Metabolic CD34+ cells"

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Shen, Yao-An, Yau-Huei Wei, and Yann-Jang Chen. "Abstract 482: High CD44/CD24 expressive cells presented cancer stem cell characteristics and undergo mitochondrial resetting and metabolic shift in nasopharyngeal carcinoma." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-482.

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Dimitriu, Gabriel, Vasile lucian Boiculese, Mihaela Moscalu, and Cristina gena Dascalu. "GLOBAL SENSITIVITY ANALYSIS APPLIED TO A CANCER IMMUNOTHERAPY MODEL." In eLSE 2019. Carol I National Defence University Publishing House, 2019. http://dx.doi.org/10.12753/2066-026x-19-177.

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Sensitivity analysis methods have a long history and have been widely applied in different fields, such as environmental modeling, economical modeling for decision making, parameter estimation and control, chemical kinetics, and biological modeling analysis, with metabolic networks, signaling pathways and genetic circuits. Cancer immunotherapy is based on the idea of immune surveillance. Immunotherapy, also named biologic therapy, represents a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or r
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Wang, Haiping, and Ping-Chih Ho. "Abstract A223: CD36-mediated metabolic adaptation guides regulatory T-cells in tumors." In Abstracts: Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 30 - October 3, 2018; New York, NY. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr18-a223.

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Von Gerichten, Johanna, Annette Holland, Barbara Fielding, Elizabeth Miles та Graham Burdge. "α-Linolenic acid metabolism in human CD3+ T cells favours oxylipin production over polyunsaturated fatty acid synthesis". У 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/asgv6871.

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The essential dietary fatty acid α-linolenic acid (ALA) can be converted into anti-inflammatory 18 carbon oxylipins or into longer chain n€‘3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The partitioning of ALA between these alternative metabolic fates is not understood. To address this, peripheral blood CD3+ T cells from healthy volunteers (18-30 years; n=10) were cultured for 48h, with or without concanavalin A (10µg/ml) in 10% (v/v) pooled donor plasma with low ALA (20 µM) or high ALA (40 µM) concentrations (1:10 [13C]€‘labelled/unl
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Chmielewski, Jeffrey P., Frances Wheeler, Scott Cramer, Shi Lihong, Joseph Sirintrapun, and Steven J. Kridel. "Abstract A33: CD38 and Nampt regulate tumor cell metabolism through modulation of NAD+." In Abstracts: AACR Special Conference: Metabolism and Cancer; June 7-10, 2015; Bellevue, WA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3125.metca15-a33.

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Tamada, Mayumi, Makoto Suematsu, and Hideyuki Saya. "Abstract 5424: CD44-mediated glucose metabolism affects ROS level and drug sensitivity in glycolytic cancer cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5424.

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Iwata, S., K. Sakata, M. Hajime, et al. "30 Metabolic reprogramming in cd4+cd28-cxcr3intt-bethi cells and its relevance to pathogenesis in patients with sle." In LUPUS 2017 & ACA 2017, (12th International Congress on SLE &, 7th Asian Congress on Autoimmunity). Lupus Foundation of America, 2017. http://dx.doi.org/10.1136/lupus-2017-000215.30.

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Zhou, Gang, Tsadik Habtetsion, and Zhi-Chun Ding. "Abstract 1533: CD4+ T cells reprogram tumor metabolism and drive oxidative stress-induced tumor destruction." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1533.

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Zhou, Gang, Tsadik Habetesion, and Zhi-Chun Ding. "Abstract A56: Alteration of tumor metabolism by antitumor CD4+ T cells leads to tumor rejection." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; November 27-30, 2018; Miami Beach, FL. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/2326-6074.tumimm18-a56.

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Evans, William, Jazmine Eccles, and William Baldwin. "Changes in Energy Metabolism Induced by PFOS and Dietary Oxylipins." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/jnpe5541.

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CYP2B6 is a drug metabolizing cytochrome P450 (CYP) that has anti-obesity properties, but also increases non-alcoholic fatty liver disease (NAFLD) in hCYP2B6-transgenic mice compared to Cyp2b-null mice. hCYP2B6-transgenic mice are also more susceptible to perfluorooctane sulfonic acid (PFOS) toxicity, a lipid-like toxicant used in stains, varnishes and firefighting foams that increase NAFLD. Our recent research demonstrates that CYP2B6 metabolizes dietary polyunsaturated fatty acids into the oxylipins, 9-HODE and 9-HOTre, which are strong peroxisome proliferator activated receptor alpha (PPARa
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Reports on the topic "Metabolic CD34+ cells"

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Avihingsanon, Yingyos, Jongkonnee Wongpiyabovorn, and Nattiya Hirankarn. Biomarker discovery in systemic lupus erythematosus: genome-methylation approaches : Research report. Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.15.

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Discovery of novel biomarkers in lupus nephritis Biomarkers are needed for making diagnosis and prognosis. In lupus nephritis, conventional tests like urinalysis or serum creatinine remain inadequate for patient care. In this proposal, we focused on non-invasive tools like blood and urine mRNAs or proteins. We chose candidate genes involving regulatory T-cell, B-lymphocyte signatures or vascular protective factors. Expression of regulatory cell signature (FOXP3) in peripheral blood mononuclear cells is associated with activity of lupus nephritis. We found FOXP3 mRNA levels in PBMCs from patien
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