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Dissertations / Theses on the topic 'Metabolic CD34+ cells'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Guimarães, Tânia Maria Rocha 1963. "Perfil de expressão de células progenitoras endoteliais circulantes CD45-/ CD34+/KDR+ em mulheres hipertensas na pré-menopausa em comparação com mulheres saudáveis normotensas = Expression profile of circulating endothelial progenitor cells CD45-/ CD34+/KDR+ in hypertensive premenopausal women compared with healthy normotensive women." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317311.

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Orientadores: Cristina Pontes Vicente, Patrícia Muniz Mendes Freire de Moura<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-26T00:13:01Z (GMT). No. of bitstreams: 1 Guimaraes_TaniaMariaRocha_D.pdf: 3499853 bytes, checksum: 2767ae0d1bab61dda96ce4765cd63588 (MD5) Previous issue date: 2014<br>Resumo: As células progenitoras endoteliais (EPCs) estão envolvidas em neovasculogênese e na manutenção da homeostase vascular, sua deficiência pode ter papel na patogênese da hipertensão. Este estudo teve como objetivo analisar o perfi

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Refeyton, Alice. "La survie et les adaptations métaboliques des cellules primitives mésenchymateuses et hématopoïétiques en anoxie et anoxie/aglycémie." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0028.

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Les cellules stromales mésenchymateuses (CStroM) comprennent des cellules souches (CS) multipotentes capables de régénérer des tissus lésés par des agressions de type ischémique. Pourtant, une mortalité élevée des CStroM après transplantation est mise en évidence lors de leur prise de greffe. Par conséquent, explorer les stratégies visant à améliorer la viabilité des greffes cellulaires constitue le défi de la thérapie cellulaire. À cette fin, nous avons effectué des analyses fonctionnelles et métaboliques sur deux types de population différents contenant des CS somatiques : des CStroM et une

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3

Zancanaro, Krauss Maria Eduarda. "CD4+ T cell metabolism during Trichuris muris infection." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/cd4-t-cell-metabolism-during-trichuris-muris-infection(24eb0cc7-db70-46ea-ba49-e4fe3d5a5d03).html.

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Trichuris trichiura is a gastrointestinal dwelling nematode that infects almost 500 million people worldwide. T. muris occurs naturally in mice and is very closely related the human whipworm, making it a suitable model to dissect the immune response against the parasite. Studies using the Trichuris muris system have identified CD4+ T cells as dictators of the outcome of infection. In wild type mice, infection with a high dose of T. muris eggs leads to resistance and worm expulsion, which are dependent on a Th2 response and the secretion of type 2 cytokines especially interleukin (IL) 13. Chron

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St-Pierre, Jessica. "The role of CD4⁺ Foxp3⁺ naturally-occurring regulatory T cells in the host immune response to Plasmodium chabaudi AS /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111941.

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Naturally-occurring CD4+Foxp3+ regulatory T cells (nTreg) play a central role in maintaining immune self-tolerance as well as modulating immunity towards pathogens. Pathogens may establish chronic infections in immunocompetent hosts by engaging nT reg in order to promote immunosuppression. The goal of the research described here is to test the hypothesis that nTreg modulate protective immunity to malaria, and consequentially affect susceptibility to the parasite. To investigate this question, the functional dynamics of CD4+Foxp3 + nTreg cells were evaluated in mice infected with blood-stage Pl

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5

Tripmacher, Robert. "Untersuchungen zu Wirkungen einer eingeschränkten Energiesynthese auf Funktionen von humanen Immunzellen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15260.

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Hintergrund: Die Funktion von Immunzellen hängt von einer konstanten und ausreichenden Energieversorgung ab, die über die OXPHOS in den Mitochondrien und die Glykolyse im Zytosol realisiert wird. Die wichtigsten Substrate dafür sind Sauerstoff und Glukose. Fragestellung: Bei schweren Erkrankungen oder in Entzündungsgebieten ist die zelluläre Energieversorgung stark beeinträchtigt, weil in der Mikroumgebung der Zelle Sauerstoff und Nährstoffe inadäquat bereitgestellt werden. Ziel war herauszufinden, ob und wie humane Immunzellen ihre Lebensfähigkeit und funktionellen Aktivitäten unter solchen U

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COMPAGNONE, MIRCO. "ΔNp63 controls hyaluronic acid metabolism and signaling in head and neck squamous cell carcinoma". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/202937.

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La famiglia di p53 comprende i tre fattori di trascrizione p53, p63 e p73. Il capostipite della famiglia, p53, è definito il “guardiano del genoma”, grazie alla sua abilità di arrestare il ciclo cellulare in presenza di danno al DNA, consentendone una adeguata riparazione e, nell’eventualità che tale danno non possa essere riparato, promuovere la morte cellulare per apoptosi. p53, dunque, agisce funzionalmente come un classico soppressore di tumore. Infatti, mutazioni con perdita di funzione colpiscono il gene p53 nel 50% circa dei tumori umani. Dopo circa vent’anni di studi intensivi su p53,

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7

Bourinet, Manon. "Contribution des cellules innées lymphoïdes NKp46+ et régulation de leurs fonctions par CD44 au cours de la stéatohépatite métabolique." Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6008.

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La maladie hépatique stéatotique associée à un dysfonctionnement métabolique (MASLD) est l'une des principales causes de maladies chroniques du foie avec une prévalence mondiale de 33% en 2022. La MASLD regroupe un spectre de lésions hépatiques allant de la stéatose, (accumulation de lipides dans les hépatocytes) vers la stéatohépatite associée au métabolisme (MASH), caractérisée par une inflammation et une mort hépatocytaire. La MASH est la forme évolutive de la maladie qui peut progresser vers des stades plus sévères comme la fibrose/ cirrhose et le carcinome hépatocellulaire. Des acteurs in

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8

Divoux, Jordane. "Etude du métabolisme des lymphocytes T CD4+ Foxp3+ régulateurs à l’homéostasie et dans un contexte inflammatoire." Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS075.pdf.

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Les lymphocytes T CD4+ Foxp3+ régulateurs (Treg) participent à la régulation de l’activité du système immunitaire et sont essentiel au maintien de la tolérance immune. Ces cellules sont ainsi bénéfiques lors de pathologies auto-immunes tandis que leur action anti-inflammatoire favorise la croissance tumorale. Comprendre le fonctionnement des Treg constitue donc un axe majeur pour le développement de nouvelles stratégies thérapeutiques applicables à ces deux types de pathologies. Au cours de ce travail, nous nous sommes intéressés au métabolisme des Treg étant donné que les informations disponi

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9

Vahlas, Zoï. "Régulation métabolique de l'infection des cellules T CD4 par VIH-1 : vers de nouvelles cibles thérapeutiques." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT009.

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La susceptibilité des lymphocytes T CD4 (LT) à l'infection par VIH-1 est régulée par le métabolisme du glucose et de la glutamine. Cependant, les contributions relatives de ces nutriments à l'infection étaient peu connues lorsque j’ai débuté ma thèse. Au cours de mes travaux, j'ai identifié la glutaminolyse comme une voie majeure alimentant la phosphorylation oxydative (OXPHOS) dans les sous-populations de LT activés naïves et mémoires, et j'ai découvert que l'induction de ce réseau métabolique est nécessaire pour une infection optimale par VIH-1. J’ai constaté qu’en condition limitante en glu

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10

Aroua, Nesrine. "Etude in vivo de la chimiorésistance dans les leucémies aigues myéloïdes humaines." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30369.

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Les leucémies aigües myéloïdes (LAM) sont les leucémies les plus fréquentes chez l'adulte, caractérisée par l'expansion clonale de myéloblastes immatures. Malgré un taux élevé de rémission complète après chimiothérapie conventionnelle d'induction, le pronostic est mauvais dans les LAM à cause de fréquentes rechutes. Les rechutes sont causées par une population leucémique chimiorésistante (CLR), pouvant être enrichies en cellules souches leucémiques quiescentes (CSL). Cependant, ces hypothèses n'ont jamais été testées directement in vivo. Mon travail de thèse a été initialement consacré à valid

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11

Bishop, Kenneth D. "Egr-2 and PD-1 Are Required for Induction and Maintenance of T Cell Anergy: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/354.

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The prevalence of diabetes is approaching epidemic proportions worldwide. There is currently no cure for type 1 diabetes, and successful treatment requires constant monitoring of blood sugars and use of exogenous insulin to prevent hyperglycemia. Diabetes will be curable when pancreatic β-islet cells can be transplanted into diabetes patients without requiring long-term immunosuppression. This will require learning more about the induction of functional tolerance, a state that maintains the competence of the immune system to most antigens but protects graft-specific antigens from immune reject

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12

Shang, Yo-Jen, and 沈祐任. "The Role of CDK4-CyclinD in Metabolic Reprogramming of Cell Growth." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/90608870369131720491.

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碩士<br>國立臺灣大學<br>分子與細胞生物學研究所<br>102<br>The mechanism of cell growth is strictly regulated.Two phenomena of metabolic reprogramming are involved in cell growth, including Warburg effect and Glutamine-dependent anaplerosis, which are regulated by PI3K/AKT/mTOR pathway. Under growth factors stimulation, cellular protein levels of Hypoxia induce factor-1α (HIF-1α) and c-Myc are massively increased by mechanistics target of rapamycin complex 1 (mTORC1). Our data show that CDK4-cyclin D complex increases protein level of c-Myc. Furthermore, our results demonstrate that increased c-Myc causes activati

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13

Galgani, Mario. "Role of Leptin and metabolism in survival of autoreactive CD4+ T cells." Tesi di dottorato, 2009. http://www.fedoa.unina.it/3952/2/Galgani_OK.pdf.

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Recent evidence has shown that leptin, the adipose-tissue derived hormone, can influence T cell homeostasis and survival through the control of genes involved in these processes. Leptin deficient ob/ob mice and humans show reduced circulating number of T cells particularly in the CD4+ compartment. Here, we investigate in vivo how leptin controls survival and proliferation of normal and autoreactive CD4+ T cells. We have previously observed the impaired capacity of myelin-olygodendrocyte glycoprotein peptide (MOG35-55)-specific CD4+ T cells, to transfer experimental autoimmune encephalomyeleiti

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14

Gerriets, Valerie. "Glucose Metabolism in CD4+ T cell Subsets Modulates Inflammation and Autoimmunity." Diss., 2014. http://hdl.handle.net/10161/8653.

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<p>Understanding the mechanisms that control T cell function and differentiation is crucial to develop new strategies to modulate immune function and prevent autoimmune and inflammatory disease. The balance between effector (Teff; Th1, Th2 and Th17) and regulatory (Treg) T cells is critical to provide an appropriate, but not excessive, immune response and therapies to induce Treg or inhibit Teff are likely promising treatment strategies. It has recently become clear that T cell metabolism is important in both T cell activation and differentiation. T cells undergo a metabolic reprogramming upon

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15

Craveiro, Marco Filipe Marques. "Resveratrol-induced activation of the Sirt1/AMPK axis in human CD4 T cells triggers replicative stress and an ATR-dependent cell cycle arrest." Doctoral thesis, 2014. http://hdl.handle.net/10316/23746.

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Tese de doutoramento em Bioquímica, na especialidade de Biologia Celular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnolologia da Universidade de Coimbra<br>A activação de linfócitos T, desencadeada por acoplamento do receptor de células T e por várias citocinas, pode apenas ocorrer após a célula gerar energia suficiente. A resposta às crescentes necessidades biossintéticas de uma célula T activada pode ser alcançada pelo aumento da disponibilidade de nutrientes e pela adopção de um metabolismo anabólico, permitindo optimizar a produção de ATP. Em muitos ti

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16

Tsai, Yi-Chieh, and 蔡佾倢. "High-density lipoprotein (HDL) promotes energy metabolism by attenuating palmitic acid-induced switch CD36 to GLUT4 and autophagic cell death in H9c2 cardiomyoblast cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/p7gw48.

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碩士<br>中國醫藥大學<br>基礎醫學研究所碩士班<br>102<br>PART1: Metabolic syndrome is a group of risk factors that increase heart disease and other health problems. The risk factors for development of metabolic syndrome include hyperglycemia, hyperlipidemia, hypertension, low levels of HDL and high levels of triglyceride. Acute toxicity from accumulation of long-chain fatty acids lead to cardiovascular diseases, a phenomenon known as lipotoxicity. Lipoptoxicity leads to imbalance of energy metabolism and result in cardiac dysfunction and contractile dysfunction. Cardiomyocytes use fatty acid (50-70%) and glucose

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