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1

Farooqui, Akhlaq A. Metabolic syndrome: An important risk factor for stroke, Alzheimer disease, and depression. Springer, 2013.

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2

Jay, Lombard, and Monte Tom, eds. Freedom from disease: The breakthrough approach to preventing cancer, heart disease, alzheimer's, and depression by controlling insulin. St. Martin's Griffin, 2009.

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3

Jay, Lombard, and Monte Tom, eds. Freedom from disease: The breakthrough approach to preventing cancer, heart disease, Alzheimer's, and depression by controlling insulin. St. Martin's, 2008.

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4

Donard, Dwyer, ed. Glucose metabolism in the brain. Academic Press, 2002.

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5

Osher, Susan. One-carbon metabolism in adults with major depression. National Library of Canada, 1999.

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6

Jones, Shirley Anne. Tetrahydrobiopterin metabolism in depression and senile dementia of Alzheimer type. Aston University. Department of Pharmaceutical Sciences, 1988.

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7

Laakmann, G. Psychopharmaco-endocrinology and depression research. Springer-Verlag, 1990.

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8

Laakmann, G. Psychopharmakoendokrinologie und Depressionsforschung. Springer-Verlag, 1988.

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9

B, Matchar David, United States. Agency for Healthcare Research and Quality., and Duke University Evidence-based Practice Center., eds. Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs). Agency for Healthcare Research and Quality, 2007.

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10

Nuno, Azóia, and Dobreiro Pedra, eds. Treadmill exercise and its effects on cardiovascular fitness, depression, and muscle aerobic function. Nova Science Publisher, 2009.

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11

Clare, Stanford S., ed. Selective serotonin reuptake inhibitors (SSRIs): Past, present, and future. R.G. Landes, 1999.

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12

Keith, Lierre. The vegetarian myth: Food, justice and sustainability. Flashpoint Press, 2009.

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13

Gissey, Lidia Castagneto, James R. Casella Mariolo, Geltrude Mingrone, and Francesco Rubino. Metabolic surgery and depression. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0012.

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The incidence of obesity is rising worldwide and so are its comorbidities: type-2 diabetes mellitus (T2DM), dyslipidaemia, hypertension, cardiovascular disease, sleep apnoea, and depression. Bariatric/metabolic surgery has established itself over the past several years as an effective treatment not only for morbid obesity but also for its associated morbidities. The effects of bariatric/metabolic surgery on depression are controversial, with some studies showing improvement and others demonstrating a worsening. However, a major drawback of these studies is that they do not compare patients wit
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14

Bertocci, Michele A., and Mary L. Phillips. Neuroimaging of Depression. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0025.

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This chapter illustrates the historical progression, methodological approaches, and current neurobiological understanding of depression, the first leading cause of mental and behavioral disorder disability in the United States. We describe and position, in relation to depressive symptoms, the complex abnormalities that depressed adults and youth show concerning neural function during tasks and at rest, structural abnormalities, as well as key neurotransmitter, neuroreceptor, and metabolic abnormalities that have been examined in the literature. We also describe newer findings and methods such
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15

Farooqui, Akhlaq A. A. Metabolic Syndrome: An Important Risk Factor for Stroke, Alzheimer Disease, and Depression. Springer, 2015.

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16

Farooqui, Akhlaq A. Metabolic Syndrome: An Important Risk Factor for Stroke, Alzheimer Disease, and Depression. Springer, 2013.

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17

Cortical Spreading Depression of Leao: From Mitochondrial Function to Brain Metabolic Score. Springer International Publishing AG, 2023.

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18

Sonn, Judith, and Avraham Mayevsky. Cortical Spreading Depression of Leao: From Mitochondrial Function to Brain Metabolic Score. Springer International Publishing AG, 2022.

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19

Goldstein, Jill M., L. Holsen, S. Cherkerzian, M. Misra, and R. J. Handra. Neuroendocrine Mechanisms of Depression. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0029.

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Studies have demonstrated that major depressive disorder (MDD) is intimately tied to neuroendocrine dysregulation. This arises, in part, from the fact that brain regions that regulate mood also regulate primary neuroendocrine axes and metabolic functions. We and others demonstrated that the origin of MDD-neuroendocrine deficits begins in fetal development, is sex-dependent, emerges just post-puberty, and can be catalyzed by pregnancy (postpartum) and menopause. Here, we critically review clinical and preclinical studies to argue that higher MDD risk in women may arise, in part, from hormone-de
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20

Freedom from Disease: The Breakthrough Approach to Preventing Cancer, Heart Disease, Alzheimer's, and Depression by Controlling Insulin. St. Martin's Press, 2008.

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21

H, R. S. Radical Theory on Men Metabolic Syndrome/infertility (MetS) and Depression (BPD/Dysthymia/Bipolar/Major). Independently Published, 2019.

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22

Ismail, Khalida, Andreas Barthel, Stefan R. Bornstein, and Julio Licinio, eds. Depression and Type 2 Diabetes. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.001.0001.

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Type 2 diabetes is predicted to affect between 10% and 25% of the world population in the next 20 years. Depression is a common comorbid condition in those affected with type 2 diabetes, and the combination of these conditions is associated with a poorer prognosis, including earlier mortality. Genetic and epigenetic predisposition and overlap of risk factors related to our modern lifestyle seem to drive the shared biology of diabetes and depression. This book aims to provide an understanding of the sequelae of events leading to the frequent comorbidity of diabetes and depression. This book pro
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23

Lebovitz, Harold E., and Shlomo Ben-Haim. Novel technologies: What does gastric electrical stimulation offer to the patient with type 2 diabetes and depression? Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0014.

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Owing to the epidemiologic dimensions of type 2 diabetes, obesity, and depression, the development of novel and effective treatment options for these conditions is of great importance. One of the major challenges in this field is that many antidiabetic and antidepressive drugs may have disadvantageous metabolic effects by increasing weight and worsening insulin resistance. Novel technologies more effectively considering the pathophysiological changes related to this entity are needed. The DIAMOND electrical stimulation device improves glycaemic control, causes weight loss and decreases systoli
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24

Waldemar, Gunhild. Diagnosing Alzheimer’s disease in clinical practice. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199569854.003.0005.

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• In the current clinical criteria, the diagnosis of Alzheimer’s disease (AD) is a clinical diagnosis based on characteristic symptoms and signs, and the exclusion of other causes.• AD must be differentiated from cognitive impairment due to depression, metabolic conditions, substance abuse, and other neurodegenerative or vascular brain diseases...
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25

Dwyer, Donard. Glucose Metabolism in the Brain. Elsevier Science & Technology Books, 2002.

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26

Potter, Gregory D. M., and Eleanor M. Scott. Targeting the circadian system. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0016.

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Circadian (approximately 24-hour) rhythms are generated by a hierarchical system responsible for coordinating behaviour and physiology throughout the 24-hour day. Increasing evidence supports roles for disruption of the circadian system in the development of type 2 diabetes (T2DM) and depression. We outline the key aspects of circadian system regulation, discuss the findings indicating that biological disruption of the circadian system produces various behavioural and metabolic abnormalities, and review human studies which show that environmental disruption of the circadian system contributes
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27

Young, Allan H., and Mario F. Juruena. Hypothalamic–pituitary–adrenal axis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0006.

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Increased adrenocortical secretion of hormones, primarily cortisol in depression, is one of the most consistent findings in neuropsychiatry. The maintenance of the internal homeostatic state of an individual is facilitated by the ability to circulate glucocorticoids to exert negative feedback on the secretion of hypothalamic–pituitary–adrenal (HPA) hormones through binding to mineralocorticoid and glucocorticoid receptors, thus limiting the vulnerability to diseases related to psychological stress in genetically predisposed individuals. The HPA axis response to stress can be thought of as a cr
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28

Depression: A psychobiological synthesis. Wiley, 1985.

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29

Depression: A Psychobiological Synthesis. John Wiley & Sons, 1988.

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30

Kamat, Deepak M., Henry M. Adam, and Rebecca A. Baum, eds. Quick Reference Guide to Pediatric Care. 2nd ed. American Academy of Pediatrics, 2017. http://dx.doi.org/10.1542/9781610021128.

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Significantly revised and updated, the second edition of this popular quick reference guide provides information and advice on 190 areas of current pediatric care, everything from abdominal pain and ADHD, to headache and herpes infections, to weight loss and wheezing. This indispensable resource delivers practical, action-orientated, clinical solutions for healthcare professionals to use during or between patient encounters. Authoritative content is presented in a concise outline format that helps speed and simplify decision-making. Regardless of the patient presentation you're confronted with
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31

McEwen, Bruce S., and Natalie L. Rasgon. The Brain and Body on Stress. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0002.

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Neuroscientists have treated the brain in isolation from the rest of the body, while endocrinology and general medicine have viewed the body largely without regard to the influence of systemic physiology and pathophysiology on higher brain centers outside of the hypothalamus and pituitary gland. But now there is greater recognition of brain–body interactions affecting the limbic and cognitive systems of brain and altering systemic physiology; these are conceptualized as allostasis and allostatic load and overload. These concepts look at both the interactions of brain and body to stressors and
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32

Landsbergis, Paul A., Marnie Dobson, Anthony D. LaMontagne, BongKyoo Choi, Peter Schnall, and Dean B. Baker. Occupational Stress. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0017.

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This chapter describes sources of stress in the work environment, their adverse effects on the health of workers, and how they are influenced by economic globalization, political systems, laws, government policies, and the changing labor market. Models of occupational stress, in particular job strain and effort-reward imbalance, are presented. Additional occupational stressors are described, including long work hours, shift work, precarious work and job insecurity, work-family conflict and organizational injustice, including discrimination, harassment, and bullying. The health and safety conse
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33

Sousa Alves, Gilberto, Felipe Kenji Sudo, and Johannes Pantel. The treatment of bipolar disorder in the elderly. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0022.

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Bipolar disorder (BD) is an extremely disabling condition characterized by mood switches, and cognitive and functional impairment. The current chapter discusses the updated review on pharmacological and non-pharmacological interventions targeting BD in the elderly. The risk of concurrent medical diseases (eg, metabolic syndrome) and relatively lower tolerability than young BD make the patient safety a major concern in most cases. Evidence-based guidelines, although useful for promoting rational and effective therapy, are generally lacking in elderly BD. Current recommendations for acute mania
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34

Kliger, Alan S., and Rita Suri. Frequent haemodialysis. Edited by Jonathan Himmelfarb. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0262_update_001.

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Haemodialysis is a renal replacement treatment, an ‘artificial kidney’ that performs some of the functions of the normal kidney. It is an inelegant device, providing only a fraction of native kidney’s ability to filter toxins from the blood, but with none of the responsiveness to volume, fine feedback control to regulate solute concentrations, or endocrine functions of the healthy organ. Conventional haemodialysis performed three times a week for 4 hours per treatment filters the blood for only 12 of 168 hours each week, and removes less than 10 per cent of small solutes like urea than does th
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35

Laakmann, G. Psychopharmacoendocrinology and Depression Research. Springer London, Limited, 2012.

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36

Laakmann, G. Psychopharmacoendocrinology and Depression Research. Island Press, 1990.

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37

Cozza, Kelly L., Rita Rein, Gary H. Wynn, and Eric G. Meyer. Psychopharmacology of Depression as a Systemic Illness for Primary and Specialty Care Clinicians. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0010.

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There are nearly 4 million patients with depression followed by primary care in the United States, with nearly 80% of prescriptions for antidepressants written by non-psychiatrists (Mark et al. 2009). Understanding and utilizing psychopharmacology is a critical skill for primary care physicians, who are often initial or sole prescribers. Persons with medical illnesses and depression are often prescribed a multitude of medications, necessitating attention to pharmacodynamic, pharmacokinetics, and an understanding of intended effects, side effects, toxicities, and drug interactions. This chapter
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38

Laakmann, G. Psychopharmakoendokrinologie und Depressionsforschung. Springer London, Limited, 2013.

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39

Laakmann, G. Psychopharmakoendokrinologie und Depressionsforschung. Springer Berlin Heidelberg, 2011.

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40

Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs). AHRQ, 2007.

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41

Nixon, Heather C. Voltage Disturbances During Pregnancy. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0052.

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This chapter covers the incidence, etiology, and treatment of the most common electrocardiogram and rhythm disturbances encountered during pregnancy. Baseline electrocardiogram changes associated with pregnancy include left ventricular hypertrophy and ST segment depressions secondary to anatomic and metabolic changes of pregnancy. The most common arrhythmias include atrial and ventricular ectopy, which are usually benign in nature. Supraventricular and ventricular tachycardia are also discussed in detail, along with the impact of antiarrhythmic and electrical conversion therapy on fetal and ma
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42

Cavacuiti, Christopher. The Pharmacology of Opioids (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190265366.003.0008.

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This chapter focuses on the attributes of and component medications within the class of opioids, emphasizing kinetics, dynamics, and therapeutic and adverse effects. To help patients make informed decisions about opioid use, the clinicians prescribing these medications must be able to explain when opioids are likely to help and when they are likely to do harm. Subclasses of opioids include phenanthrenes, benzomorphans, phenylpiperidines, and diphenylheptanes; examples are given of each, with respective utilities and limitations. A discussion then follows of pharmacodynamics, pharmacokinetics,
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43

Justice, Greg, and Art Still. Short & Tall of Sleep: Increase Your Metabolism, Elevate Your Immune System and Reduce the Risk of Depression and Anxiety, Through Better Sleep. Independently Published, 2020.

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44

Hodgkiss, Andrew. Psychiatric consequences of particular cancers. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198759911.003.0004.

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Certain tumour types can cause psychopathology through direct biological mechanisms such as metastatic spread to the brain, release of onconeuronal antibodies, ectopic hormone secretion, or release of pro-inflammatory cytokines. Lung cancers, adenocarcinoma of the pancreas, brain tumours, and ovarian tumours are considered in detail. Confusional states due to brain metastases, syndrome of inappropriate ADH secretion, hypercalcaemia of malignancy, and anti-Hu encephalitis are found in lung cancers. Severe depression, due to interleukin-6 release and its actions on the HPA axis and tryptophan me
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45

Sedel, Frédéric, and Yann Nadjar. Neurological and Psychiatric Symptoms. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0067.

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Late-onset forms of inborn errors of metabolism (IEM) first presenting in adulthood often display psychiatric or neurological manifestations, including atypical psychosis or depression, unexplained coma, peripheral neuropathy, cerebellar ataxia, spastic paraparesis, dementia, movement disorders, or epilepsy. With the exception of several review articles, most if not all existing books and diagnostic algorithms refer to pediatric forms of these diseases. Late-onset forms of IEM always display attenuated phenotypes, which in some instances are associated with one or more clinical manifestations
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46

Alavi, Abass, and Andrew B. Newberg. Functional Neuroimaging: A Transformative Tool for Integrative Psychiatry. Edited by Anthony J. Bazzan and Daniel A. Monti. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190690557.003.0014.

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Functional neuroimaging with positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI) can be highly useful in the evaluation and management of patients with psychiatric disorders. PET and SPECT imaging typically evaluate cerebral metabolism and blood flow, respectively, and can determine patterns associated with different disorders such as depression or schizophrenia. PET and SPECT imaging can also evaluate neurotransmitter changes such as dopamine or serotonin associated with different psychiatric disorders. fMRI
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47

Brown, Malcomb R. trends in bipolar disorder research. Nova Science Publishers, 2004.

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48

Brüne, Martin, and Wulf Schiefenhövel, eds. Oxford Handbook of Evolutionary Medicine. Oxford University Press, 2019. http://dx.doi.org/10.1093/oxfordhb/9780198789666.001.0001.

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Medicine is grounded in the natural sciences, among which biology stands out with regard to the understanding of human physiology and conditions that cause dysfunction. Ironically, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunolog
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49

Nielsen, David A., Dmitri Proudnikov, and Mary Jeanne Kreek. The Genetics of Impulsivity. Edited by Jon E. Grant and Marc N. Potenza. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195389715.013.0080.

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Impulsivity is a complex trait that varies across healthy individuals, although when excessive, it is generally regarded as dysfunctional. Impulsive behavior may lead to initiation of drug addiction that interferes with inhibitory controls, which may in turn result in facilitation of the individual’s impulsive acts. Although environmental factors play a considerable role in impulsive behavior, a body of evidence collected in twin studies suggests that about 45% of the variance in impulsivity is accounted for by genetic factors. Genetic variants studied in association with impulsivity include t
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50

Gonder, Ulrike, ed. Ethisch Essen mit Fleisch: Eine Streitschrift über nachhaltige und ethische Ernährung mit Fleisch und die Missverständnisse und Risiken einer streng vegetarischen und veganen Lebensweise. Riva, 2021.

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