Academic literature on the topic 'Metabolic drugs'

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Journal articles on the topic "Metabolic drugs"

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Siddiqi, SheeluS, Misbahuddin, Farida Ahmad, SyedZ Rahman, and AsadU Khan. "Dyslipidemic drugs in metabolic syndrome." Indian Journal of Endocrinology and Metabolism 17, no. 3 (2013): 472. http://dx.doi.org/10.4103/2230-8210.111644.

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Finsterer, Josef, and Marlies Frank. "Repurposed Drugs in Metabolic Disorders." Current Topics in Medicinal Chemistry 13, no. 18 (2013): 2386–94. http://dx.doi.org/10.2174/15680266113136660166.

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Poiana, Catalina. "Metabolic effects of psychotropic drugs." Acta Endocrinologica (Bucharest) 6, no. 3 (2010): 394. http://dx.doi.org/10.4183/aeb.2010.394.

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Patil, AnantD. "Antidyslipidemic drugs in metabolic syndrome." Indian Journal of Endocrinology and Metabolism 17, no. 6 (2013): 1133. http://dx.doi.org/10.4103/2230-8210.122652.

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M. Suter, Paolo M., and Wilhelm Vetter. "Metabolic effects of antihypertensive drugs." Journal of Hypertension 13, supplement4 (1995): S11—S17. http://dx.doi.org/10.1097/00004872-199512002-00003.

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Carr, C. Jelleff. "METABOLIC STUDIES ON PSYCHOACTIVE DRUGS." Annals of the New York Academy of Sciences 96, no. 1 (2006): 170–78. http://dx.doi.org/10.1111/j.1749-6632.1962.tb50112.x.

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Mintzer, Scott. "Metabolic consequences of antiepileptic drugs." Current Opinion in Neurology 23, no. 2 (2010): 164–69. http://dx.doi.org/10.1097/wco.0b013e32833735e7.

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Fragasso, Gabriele, Alberto Margonato, Roberto Spoladore, and Gary D. Lopaschuk. "Metabolic effects of cardiovascular drugs." Trends in Cardiovascular Medicine 29, no. 3 (2019): 176–87. http://dx.doi.org/10.1016/j.tcm.2018.08.001.

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BATES, BETSY. "Antipsychotic Drugs Spur Metabolic Changes." Family Practice News 40, no. 12 (2010): 38. http://dx.doi.org/10.1016/s0300-7073(10)70767-2.

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Davis, Vanessa, and Arlan L. Rosenbloom. "Metabolic effects of antipsychotic drugs." Pediatric Diabetes 7, no. 3 (2006): 176–86. http://dx.doi.org/10.1111/j.1399-543x.2006.00178.x.

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Dissertations / Theses on the topic "Metabolic drugs"

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CANAVESI, ROSSANA. "Chemical and metabolic stability studies of propargylamine-containing drugs." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115197.

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Rautio, K. (Katriina). "Effects of insulin-lowering drugs in PCOS: endocrine, metabolic and inflammatory aspects." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:951428268X.

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Abstract Most women with polycystic ovary syndrome (PCOS) exhibit features of metabolic syndrome, including insulin resistance, abdominal obesity, dyslipidaemia, glucose intolerance and low-grade chronic inflammation, reflected in elevated levels of serum C-reactive protein (CRP), placing these women at increased risk of cardiovascular disease and type 2 diabetes (type 2 DM). The aim of this study was to investigate the effects of two well-known insulin-lowering drugs used in the treatment of type 2 DM, metformin and rosiglitazone, on traditional cardiovascular risk factors and inflammation i
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Zeitz, Christopher John. "Acute drug effects on the heart-haemodynamic, pharmacologic and metabolic correlations." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phz48.pdf.

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Addenda and corrigenda inserted on verso of back end paper. Includes: Publications and communications to learned societies (p. 4-5). Bibliography: leaves 272-286. Examines the acute myocardial uptake of drugs, particularly perindoprilat and enalaprilat in humans. The uptake of these agents is examined, together with the haemodynamic, metabolic and biochemical effects. In particular, the impact of these agents on angiotensin and bradykinin peptides both within the heart and peripherally is described. The acute effects of a range of cardioactive drugs upon the left ventricular force-interval rel
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Wändell, Per. "Diabetes in primary care : quality of life, metabolic control, drugs and socioeconomic factors /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2712-X.

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Benedetti, Brad. "Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/195.

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Platinum drugs are among the most commonly used chemotherapeutics for the treatment of testicular, head and neck, ovarian, small cell lung, and colorectal carcinomas. Although the current set of platinum chemotherapeutics has proven somewhat successful, the overall success of platinum based drugs is limited due to acquired drug resistance and a limited range of tumor types that are treatable with the current regime. The development of novel cytotoxic platinum based compounds, both trans- and polynuclear, provides for the promising treatment of clinical platinum drug resistant tumors. While t
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Bowers, Gary David. "Applications of mass spectrometric techniques to the monitoring of drugs and their metabolic conjugates in biological media." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363143.

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Abu-Zahra, Tawfic Nessim. "Hepatic clearance of drugs, effect of zonal factors; transport and metabolic studies on enalapril with rat, zonal hepatocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0028/MQ50449.pdf.

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McGuire, Marlene. "Expensive drugs for rare diseases : an anthropological analysis of the cultural, political, and economic dimensions of metabolic disease." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39881.

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In the context of Canada’s publicly funded universal health care system, access to potentially life-saving and/or life lengthening orphan drugs costing anywhere from $100,000.00 to $850,000.00 per patient per year is a complicated matter. This study is an anthropological examination of the debates surrounding ‘expensive drugs for rare diseases’, a term that has come to represent the costly treatments developed for rare metabolic diseases like Mucopolysaccharidosis, Pompe Disease, Fabry Disease, and Phenylketonuria. This study was conducted in British Columbia, Canada. It is based on sever
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Sinxadi, Phumla Z. "Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20329.

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BACKGROUND: Antiretroviral therapy (ART), notably efavirenz and lopinavir, have been associated with metabolic abnormalities known to increase cardiovascular risk. Efavirenz and lopinavir pharmacokinetics demonstrate considerable interindividual variability, which in part, may be explained by host genetic factors. Mitochondrial DNA (mtDNA) variation influences ART related metabolic complications. However, the associations between genetic polymorphisms and pharmacokinetics of antiretroviral drugs, and their associations with metabolic complications, are incompletely understood. We explored asso
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Lindauer, Carina Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Toxicokinetics of Emerging Drugs of Abuse : In vivo and in vitro studies on the metabolic fate of the cocaine-derived designer drug dimethocaine / Carina Lindauer. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1067841555/34.

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Books on the topic "Metabolic drugs"

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1962-, Thakore Jogin H., and Leonard B. E, eds. Metabolic effects of psychotropic drugs. Karger, 2009.

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H, Jeffery Elizabeth, ed. Human drug metabolism: From molecular biology to man. CRC Press, 1993.

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C, Kauffman Frederick, and Bock K. W. 1935-, eds. Conjugation-deconjugation reactions in drug metabolism and toxicity. Springer-Verlag, 1994.

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Peter, Eyer, ed. Metabolic aspects of cell toxicity. Wissenschaftsverlag, 1994.

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Goudot-Perrot, Andrée. Metabolic inhibitors: Antibiotics - antimitotics - psychotropics. Schwer Verlag, 1992.

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Emel, Arinç, Schenkman John B, and Hodgson Ernest 1932-, eds. Molecular and applied aspects of oxidative drug metabolizing enzymes. Plenum Press, 1999.

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J, Mulder Gerard, ed. Conjugation reactions in drug metabolism: An integrated approach : substrates, co-substrates, enzymes and their interactions in vivo and in vitro. Taylor & Francis, 1990.

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Lau, Grace S. N. Metabolic activation of drugs and other xenobiotics in hepatocellular carcinoma. Chinese University Press, 1997.

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1955-, Mrsny Randall J., and Daugherty Ann L. 1954-, eds. Proteins and peptides: Pharmacokinetic, pharmacodynamic, and metabolic outcomes. Informa Healthcare, 2010.

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Predrag, Cudic. Peptide modifications to increase metabolic stability and activity. Humana Press, 2013.

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Book chapters on the topic "Metabolic drugs"

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Seifert, Roland. "Drugs for Metabolic Disorders." In Drugs Easily Explained. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-12188-3_6.

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Chester, Neil. "Hormone and metabolic modulators." In Drugs in Sport. Routledge, 2018. http://dx.doi.org/10.4324/9781315222790-12.

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Chester, Neil. "Hormone and metabolic modulators." In Drugs in Sport, 8th ed. Routledge, 2021. http://dx.doi.org/10.4324/9781003096160-13.

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Grundy, S. M. "Metabolic Syndrome: Therapeutic Considerations." In Atherosclerosis: Diet and Drugs. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-27661-0_3.

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Ensinger, E., and K. Träger. "Metabolic Effects of Adrenergic Drugs." In Yearbook of Intensive Care and Emergency Medicine 2002. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-56011-8_46.

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Ensinger, E., and K. Träger. "Metabolic Effects of Adrenergic Drugs." In Intensive Care Medicine. Springer New York, 2002. http://dx.doi.org/10.1007/978-1-4757-5551-0_46.

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Compston, Juliet. "Skeletal Effects of Drugs." In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118453926.ch64.

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Mayer, J. M., and B. Testa. "Stereoselectivity in Metabolic Reactions of Toxication and Detoxication." In Pharmacokinetics of Drugs. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78680-8_7.

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Bronzetti, Gabriele. "Drugs, Electrolyte Abnormalities, and Metabolic Factors." In Atlas of Pediatric and Youth ECG. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-57102-7_7.

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Weil, A., J. Caldwell, M. Strolin-Benedetti, and P. Dostert. "Species Differences in the Metabolic Disposition of Fenofibrate." In Drugs Affecting Lipid Metabolism. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71702-4_60.

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Conference papers on the topic "Metabolic drugs"

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Mekha, Sarah, Enakshi Sunassee, Miguel Salgado, et al. "Multi-probe Metabolic Fluorescence Microscopy Captures Poor Tumor Immunogenicity." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2025. https://doi.org/10.1364/omp.2025.om1e.3.

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Visualizing complex tumor-immune metabolic interactions is imperative to understanding cancer progression. Cocultures of 4T1 tumor cells and CD8+ T cells were imaged for glucose uptake and mitochondrial metabolism. Results point to poor immunogenic tumor phenotype.
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Datta, Rupsa, Veronika Miskolci, Gina M. Gallego-López, et al. "Metabolic Characterization of Neutrophil Activation Using Label-Free Fluorescence Lifetime Imaging Microscopy." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2025. https://doi.org/10.1364/omp.2025.om1e.4.

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In this work we employ fluorescence lifetime imaging microscopy of intrinsic metabolic co-factor NAD(P)H to quantify metabolic changes in neutrophils upon activation and metabolic pathway perturbations across biological systems.
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Tasmi, Tabassum Ahmad, and Alex J. Walsh. "Propofol Treatment Alters the Metabolic State of MDA-MB-231 Breast Cancer Cells." In Novel Techniques in Microscopy. Optica Publishing Group, 2025. https://doi.org/10.1364/ntm.2025.nw2c.6.

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This study investigates the impact of propofol, an intravenous anesthetic drug, on the metabolic behavior of the breast cancer cell line MDA-MB 231, by utilizing fluorescence lifetime imaging microscopy (FLIM). It revealed significant morphological and metabolic changes in the cells, which may reveal a metabolic-component to propofol’s mechanism.
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Zhang, Chi, Karsten Mohn, Bin Dong, Shivam Mahapatra, and Seohee Ma. "Coherent Raman Scattering Spectroscopy and Microscopy for Biological Studies." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2025. https://doi.org/10.1364/omp.2025.otu4e.2.

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Here, the pulse-picking method for nonlinear optical imaging modalities, including coherent anti-Stokes Raman scattering, is introduced. Furthermore, recent studies employing coherent Raman microscopy to investigate cancer cell metabolism under hypoxic conditions are discussed.
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Multari, Silvia, Rıza Özçelik, Angelica Mazzolari, Marco Salvatore Nobile, and Francesca Grisoni. "Predicting Metabolic Reactions with a Molecular Transformer for Drug Design Optimization." In 2024 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). IEEE, 2024. http://dx.doi.org/10.1109/cibcb58642.2024.10702115.

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Abbruzzese, Claudia, Susan Costantini, Isabella Romeo, et al. "Repurposing Existing Drugs for Glioblastoma therapy: A Metabolic-Based Screening Strategy." In International Drug Repurposing Conference 2025. ScienceOpen, 2025. https://doi.org/10.14293/idr.25.007ca.

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Chen, Shipeng, Ana Milena Vizcaino, Yuzhen Gao, Baukje Nynke Hoogenboom, Toos Daemen, and Cesar Oyarce. "1322 Targeting immunosuppressive macrophages and Tregs by repurposing metabolic drugs." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1322.

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Tourlomousis, Filippos, and Robert C. Chang. "2D and 3D Multiscale Computational Modeling of Dynamic Microorgan Devices as Drug Screening Platforms." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52734.

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The ability to incorporate three-dimensional (3D) hepatocyte-laden hydrogel constructs using layered fabrication approaches into devices that can be perfused with drugs enables the creation of dynamic microorgan devices (DMDs) that offer an optimal analog of the in vivo liver metabolism scenario. The dynamic nature of such in vitro metabolism models demands reliable numerical tools to determine the optimum process, material, and geometric parameters for the most effective metabolic conversion of the perfused drug into the liver microenvironment. However, there is a current lack of literature t
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Scherbakova, D., and Nadezhda Yudina. "USING METABOLIC MODELS TO PREDICT DRUG EFFICACY: APPLICATIONS IN BIOMEDICINE." In CHALLENGING ISSUES IN SYSTEMS MODELING AND PROCESSES. FSBE Institution of Higher Education Voronezh State University of Forestry and Technologies named after G.F. Morozov, 2025. https://doi.org/10.58168/cismp2024_185-189.

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The article discusses the use of metabolic models to predict the efficacy of pharmaceuticals. Metabolic models help to understand how drugs affect metabolic pathways in cells, which is crucial for developing new therapies and optimizing existing ones. The focus is on methods for modeling metabolic networks, such as flux balance analysis and constrained models. Examples are provided of how these methods are applied to evaluate therapeutic effects and potential side effects of medications.
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"Determination and Characterization of Psychoactive Drugs. Elucidation of their Metabolic Processes." In 3rd INTERNATIONAL CONFERENCE ON BIOLOGICAL RESEARCH AND APPLIED SCIENCE. Jinnah University for Women, Karachi,Pakistan, 2023. http://dx.doi.org/10.37962/ibras/2023/102-104.

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Reports on the topic "Metabolic drugs"

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Seaford, Zoe. Jugular Vein Catheterization for Continuous Multi-hour Infusions in Mice. Montana State University, 2025. https://doi.org/10.15788/1751923267.

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In vivo metabolic labeling in animal models is difficult and poorly described in method papers. This is an underutilized technique when it comes to identifying important metabolic components. In this paper we describe a detailed up to date protocol for metabolic administration of metabolites into mice. This protocol is designed to make these procedures more available to the research community. This methodology can be utilized for delivery for other compounds such as drugs and isotopes. The primary focus of this review is to emphasize that jugular catheterization is a versatile and effective wa
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Ghosal, Samit, and Binayak Sinha. The cardiovascular benefits of GLP1-RA are directly related to their positive effect on glycaemic control: A meta-regression analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.1.0071.

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Review question / Objective: P (patient population) = Type 2 diabetes patients with high CV risk or established atherosclerotic cardiovascular disease; I (intervention) = Received drugs: GLP1-RA; C (control group) = Compared to a control group that received a placebo; O (outcome) = Outcomes of interest included primary CV outcomes (MACE, CV death, MI, and Stroke). Condition being studied: To explore whether the heterogeneity associated with the primary outcomes benefits can be attributed to the metabolic improvements associated with GLP1-RA. The plan is to use HBA1c, weight, and SBP reduction
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Jin, Dachuan, Gao Peng, Shunqin Jin, Tao Zhou, Baoqiang Guo, and Guangming Li. Comparison of therapeutic effects of anti-diabetic drugs on non-alcoholic fatty liver disease patients without diabetes: A network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.11.0014.

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Review question / Objective: To evaluate the efficacy of different anti-diabetic drugs in the treatment of non-diabetic non-alcoholic disease by network meta-analysis, and find the best intervention. Condition being studied: Non-alcoholic fatty liver disease (NAFLD) refers to the disease in which the liver fat content exceeds 5%, and excludes the secondary causes of alcohol, infection, drugs or other specific metabolic diseases. As a spectrum of disorders, it includes hepatocyte steatosis and steatohepatitis at the initial stage, liver fibrosis at the later stage, cirrhosis at the final stage,
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Hu, Yang Yang, Xing Zhang, Yue Luo, and Yadong Wang. Systematic review and Meta analysis of the efficacy and safety of rifaximin in the prevention and treatment of hepatic encephalopathy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0061.

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Review question / Objective: P:Liver cirrhosis patients with risk factors associated with HE attack;HE patients caused by chronic liver diseases represented by cirrhosis. I: Rifaximin treatment. C: Other drugs or placebo. O:HE incidence; HE improvement; All-cause mortality; Blood ammonia level; PSE index; mental state; NCT-A; NCT-B; Adverse events. Condition being studied: Hepatic encephalopathy(HE) is a neuropsychiatric disorder syndrome based on metabolic disorders, which is caused by severe acute and chronic liver dysfunction or various abnormalities of portosystemic shunt (hereinafter refe
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Hawkins, David R. Determination of Drug Pharmacokinetics and Metabolic Profile. Volume 2. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada192428.

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Chipiso, Kudzanai. Biomimetic Tools in Oxidative Metabolism: Characterization of Reactive Metabolites from Antithyroid Drugs. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.3078.

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Halim, Nader. Regulation of Brain Glucose Metabolic Patterns by Protein Phosphorlyation and Drug Therapy. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ad1013984.

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Xiang, Kemeng, Huiming Hou, and Ming Zhou. The efficacy of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates on postmenopausal women with osteoporosis:A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.5.0067.

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Review question / Objective: The aim of this review is to evaluate the effectiveness of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates for postmenopausal osteoporosis. Condition being studied: Postmenopausal osteoporosis (PMOP) is a disorder of bone metabolism caused by estrogen deficiency in women after menopause, which manifests clinically as pain, spinal deformities and even fragility fractures, affecting the quality of life of patients and possibly shortening their life span. Bisphosphonates are commonly used to control and delay the progression of the disease, impro
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Liu, Shuang, Zheng-Miao Wang, Dong-Mei Lv, and Yi-Xuan Zhao. Advances in highly active one-carbon metabolism in cancer diagnosis, treatment, and drug resistance: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.11.0099.

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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed
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