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Dissertations / Theses on the topic 'Metabolic drugs'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

CANAVESI, ROSSANA. "Chemical and metabolic stability studies of propargylamine-containing drugs." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115197.

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2

Rautio, K. (Katriina). "Effects of insulin-lowering drugs in PCOS: endocrine, metabolic and inflammatory aspects." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:951428268X.

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Abstract Most women with polycystic ovary syndrome (PCOS) exhibit features of metabolic syndrome, including insulin resistance, abdominal obesity, dyslipidaemia, glucose intolerance and low-grade chronic inflammation, reflected in elevated levels of serum C-reactive protein (CRP), placing these women at increased risk of cardiovascular disease and type 2 diabetes (type 2 DM). The aim of this study was to investigate the effects of two well-known insulin-lowering drugs used in the treatment of type 2 DM, metformin and rosiglitazone, on traditional cardiovascular risk factors and inflammation i

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3

Zeitz, Christopher John. "Acute drug effects on the heart-haemodynamic, pharmacologic and metabolic correlations." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phz48.pdf.

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Addenda and corrigenda inserted on verso of back end paper. Includes: Publications and communications to learned societies (p. 4-5). Bibliography: leaves 272-286. Examines the acute myocardial uptake of drugs, particularly perindoprilat and enalaprilat in humans. The uptake of these agents is examined, together with the haemodynamic, metabolic and biochemical effects. In particular, the impact of these agents on angiotensin and bradykinin peptides both within the heart and peripherally is described. The acute effects of a range of cardioactive drugs upon the left ventricular force-interval rel

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4

Wändell, Per. "Diabetes in primary care : quality of life, metabolic control, drugs and socioeconomic factors /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2712-X.

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5

Benedetti, Brad. "Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/195.

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Platinum drugs are among the most commonly used chemotherapeutics for the treatment of testicular, head and neck, ovarian, small cell lung, and colorectal carcinomas. Although the current set of platinum chemotherapeutics has proven somewhat successful, the overall success of platinum based drugs is limited due to acquired drug resistance and a limited range of tumor types that are treatable with the current regime. The development of novel cytotoxic platinum based compounds, both trans- and polynuclear, provides for the promising treatment of clinical platinum drug resistant tumors. While t

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6

Bowers, Gary David. "Applications of mass spectrometric techniques to the monitoring of drugs and their metabolic conjugates in biological media." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363143.

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7

Abu-Zahra, Tawfic Nessim. "Hepatic clearance of drugs, effect of zonal factors; transport and metabolic studies on enalapril with rat, zonal hepatocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0028/MQ50449.pdf.

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8

McGuire, Marlene. "Expensive drugs for rare diseases : an anthropological analysis of the cultural, political, and economic dimensions of metabolic disease." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39881.

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In the context of Canada’s publicly funded universal health care system, access to potentially life-saving and/or life lengthening orphan drugs costing anywhere from $100,000.00 to $850,000.00 per patient per year is a complicated matter. This study is an anthropological examination of the debates surrounding ‘expensive drugs for rare diseases’, a term that has come to represent the costly treatments developed for rare metabolic diseases like Mucopolysaccharidosis, Pompe Disease, Fabry Disease, and Phenylketonuria. This study was conducted in British Columbia, Canada. It is based on sever

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9

Sinxadi, Phumla Z. "Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20329.

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BACKGROUND: Antiretroviral therapy (ART), notably efavirenz and lopinavir, have been associated with metabolic abnormalities known to increase cardiovascular risk. Efavirenz and lopinavir pharmacokinetics demonstrate considerable interindividual variability, which in part, may be explained by host genetic factors. Mitochondrial DNA (mtDNA) variation influences ART related metabolic complications. However, the associations between genetic polymorphisms and pharmacokinetics of antiretroviral drugs, and their associations with metabolic complications, are incompletely understood. We explored asso

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10

Lindauer, Carina Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Toxicokinetics of Emerging Drugs of Abuse : In vivo and in vitro studies on the metabolic fate of the cocaine-derived designer drug dimethocaine / Carina Lindauer. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1067841555/34.

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11

Prosser, Denise Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Toxicocinetics of Emerging Drugs of Abuse : In vivo and in vitro studies on the metabolic fate of the cathinone-derived designer drug ß-naphyrone / Denise Prosser. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1053983018/34.

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12

Vogl, Silvia [Verfasser], and Gilbert [Akademischer Betreuer] Schönfelder. "Investigation of individual differences in the metabolic elimination of drugs by the polymorphic enzymes CYP2C9, 2C19 and 2D6 based on metabolite profiling by LC-MS/MS / Silvia Vogl, geb. Baumann. Betreuer: Gilbert Schönfelder." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1019944765/34.

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13

Correia, Susana Margarida Matos. "Regulação do apetite e o papel da farmacologia." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3751.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A necessidade da compreensão dos sistemas fisiológicos que regulam o apetite aumentou consideravelmente na última década, sendo que os mecanismos de controlo do apetite têm sido estudados, focando principalmente as funções hipotalâmicas, regulando o aspeto metabólico da alimentação. Os sistemas de controlo do apetite estão muito mais voltados para o armazenamento energético do que para a perda de peso, pois sabe-se quais as difi

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14

Lee, Suhyun. "Long-term metabolic effects of stress and antidepressants : a novel paradigm of antidepressant-induced weight gain in the post-stress acclimation period." Phd thesis, Canberra, ACT : The Australian National University, 2014. http://hdl.handle.net/1885/125029.

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Despite the frequent use of antidepressants and the high incidence of obesity in Australia and many other developed countries, the relationship between major depressive disorder, obesity and antidepressant use remains complex. The association between antidepressant use and body weight gain has been widely reported. However, the pathophysiological mechanisms of this association are still poorly understood. In this thesis, an animal paradigm that addresses the "paradoxical" weight loss of rodents during antidepressant treatment was developed. The paradigm referred here as the SAD model and consi

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15

Barros, Ana Margarida. "Controlo do apetite: fármacos estimulantes e fármacos depressores." Master's thesis, [s.n.], 2011. http://hdl.handle.net/10284/2453.

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Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas.<br>Neste estudo realizou-se um inquérito com entrevistas pessoais a 50 utentes da farmácia onde foi efetuado o estágio. O questionário era composto por uma série de perguntas fechadas e pré-codificadas referentes aos seus hábitos alimentares, desporto e patologias, bem como antecedentes patológicos relacionados com problemas de excesso de peso (variáveis explicativas), de forma a poder correlacioná-las com dificuldade no controlo do apetite e o uso de medicaç

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16

Lévi, Natacha. "Impact et réversibilité du syndrome métabolique et de ses composantes sur le vieillissement cognitif et le risque de démence." Thesis, Paris Est, 2012. http://www.theses.fr/2012PEST0080.

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L’hypertension artérielle (HTA) est considérée comme un facteur de risque modifiable de démence. Dans ce contexte, nous nous sommes intéressés à différents aspects du traitement de l’HTA indépendamment de la réduction de pression artérielle : d’une part aux effets des différentes classes d’antihypertenseurs sur le déclin cognitif et l’incidence de démence, en réalisant une méta-analyse en réseau ; et, d’autre part, sur la variabilité depression artérielle (PA), qui pourrait être impliquée dans la relation délétère entre l’HTA et la cognition, à partir d’une cohorte de sujets hypertendus traité

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17

Breuker, Cyril. "Etude des xénorécepteurs CAR (NR1I3) et PXR (NR1I2) : identification d’un nouveau gène cible de CAR (SPOT14) et d’une nouvelle isoforme de PXR (PXR-small) dans l'hépatocyte humain." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON13522.

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CAR (Constitutive Androstane Receptor, NR1I3) et PXR (Pregnane X Receptor, NR1I2) sont deux récepteurs nucléaires dédiés à la reconna issance et à l'élimination de molécules lipophiles potentiellement toxiques pour l'organisme. Ces facteurs de transcription peuvent être activés par des ligands d'origines et de structures diverses (médicaments, polluants environnementaux, produits de l'alimentation et de phytothérapies). L'activation de ces récepteurs entraîne l'expression des gènes majeurs de la fonction de détoxication entéro-hépatique (CYP450, transférases, transporteurs) permettant l'élimin

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18

Griffin, Michael. "Use of in vitro metabolism models for in vivo drug metabolic clearance prediction." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487998.

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Recently human liver microsomes have been found to underpredict in vivo human intrinsic clearance (CLint); this has led to an increase in the use of fresh and cryopreserved human hepatocytes as an alternative in vitro system for the prediction of in vivo human CLint. The aim of the work in this thesis was to assess the utility of human hepatocytes for the prediction of in vivo drug metabolic clearance. It was found that fresh and cryopreserved human hepatocytes also underpredict in vivo human CLint (6 and 6 fold respectively). The effect of including the binding to the in vitro system in the c

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19

Azevedo, Maria da Glória Batista de. "Seguimento farmacoterapêutico na Síndrome Metabólica: Um ensaio clínico randomizado." Universidade Estadual da Paraíba, 2015. http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2379.

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Submitted by Jean Medeiros (jeanletras@uepb.edu.br) on 2016-03-18T12:49:18Z No. of bitstreams: 1 PDF - Maria da Glória Batista de Azevedo.pdf: 3209018 bytes, checksum: 6f8895604e3a3f7da7ae3eb068c699ff (MD5)<br>Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-07-22T15:07:50Z (GMT) No. of bitstreams: 1 PDF - Maria da Glória Batista de Azevedo.pdf: 3209018 bytes, checksum: 6f8895604e3a3f7da7ae3eb068c699ff (MD5)<br>Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-07-22T15:07:58Z (GMT) No. of bitstreams: 1 PDF - Maria da Glória Batista d

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20

Wong, Ka Yeung Mark. "Drug clearance mechanisms and chemotherapy response." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28094.

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Cytotoxic chemotherapeutic agents have a major role in the treatment of cancers. However, many cytotoxic agents have a narrow therapeutic window with best treatment response achieved only within a small range of drug concentrations.

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21

Xu, Hongmei. "Understanding variability in response to gliclazide." Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28969.

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Type 2 diabetes has become one of the most common human diseases. The safety and efficacy of antidiabetic medicines is an important part of diabetes management in the community. This thesis investigates a number of factors that may potentially cause variability in response to the antidiabetic drug gliclazide. This information will help to improve the use of these medicines in diabetic patients. Patients have free access to, and commonly take, complementary medicines for a variety of reasons. Many take these in conjunction with conventional drugs without clear evidence of safety or ris

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22

Kern, Fredy [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Myxobacterial P450s as drug metabolizers : derivatization and metabolite production of drugs / Fredy Kern. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1109790236/34.

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23

Boussadia, Badreddine. "Rôle des récepteurs nucléaires aux xénobiotiques et des enzymes métaboliques P450 cérébraux dans la physiopathologie du cerveau." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT010.

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Les récepteurs nucléaires des xénobiotiques et les enzymes métaboliques P450 (CYP) constituent les principaux éléments contrôlant la biotransformation des médicaments, ainsi que le maintien de des barrières physiologiques au niveau périphérique, plus particulièrement, dans le foie et dans l’intestin. Plusieurs études ont mis en évidence la présence des CYP ainsi que les récepteurs nucléaires contrôlant leur expression, tels que le Constitutive Androstane Receptor et le Pregnane Xenobiotic Receptor (CAR et PXR). Des résultats précédant indiquent la surexpression des CYP2E1 et CYP3A4 dans des ti

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24

SHROFF, PURVI B. "AN ASSESSMENT OF THE POTENTIAL INFLUENCE OF BEXAROTENE, A NOVEL RETINOID X RECEPTOR AGONIST, ON THE HEPATIC METABOLISM OF BEXAROTENE." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1123813553.

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25

Youssef, Amir Samaan Bishara. "Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/231985.

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Pharmaceutical Sciences<br>Ph.D.<br>Gastroparesis is a disorder characterized by delayed gastric emptying due to chronic abnormal gastric motility. Prokinetic agents such as domperidone and metoclopramide are the cornerstone in treatment of gastroparesis. Although these medications have been used for decades, essential information about their metabolism is not available. Lack of knowledge about the metabolites formed in the body upon administration of the aforementioned medications as well as the enzymes involved in their metabolism limits key information needed to make sound medical decisions

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26

Schneider, Kevin. "Covalent Protein Adduction by Drugs of Abuse." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/816.

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Recreational abuse of the drugs cocaine, methamphetamine, and morphine continues to be prevalent in the United States of America and around the world. While numerous methods of detection exist for each drug, they are generally limited by the lifetime of the parent drug and its metabolites in the body. However, the covalent modification of endogenous proteins by these drugs of abuse may act as biomarkers of exposure and allow for extension of detection windows for these drugs beyond the lifetime of parent molecules or metabolites in the free fraction. Additionally, existence of covalently bound

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27

Balcells, Nadal Cristina. "The supramolecular organization of cancer metabolism: From macromolecular crowding to metabolic reprogramming underlying cancer metastasis and drug resistance." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668321.

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Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems biology and biophysical approaches, in an attempt to find common phenotypic adaptations and metabolic vulnerabilities of metastatic and resistant cancer cells, potentially exploitable in novel combination therapies. The obtained results unveil that highly metastatic e-CSC phenotypes of CRPC present particular metabolic vulnerabilities that can potentially lead to establishing putative biomark

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28

Grundmark, Birgitta. "Prostate Cancer; Metabolic Risk Factors, Drug Utilisation, Adverse Drug Reactions." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194297.

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Increased possibilities during the last decades for early detection of prostate cancer have sparked research on preventable or treatable risk factors and on improvements in therapy. Treatments of the disease still entail significant side effects potentially affecting men during the rest of their lives. The studies of the present thesis concern different aspects of prostate cancer from etiological risk factors and factors influencing treatment to an improved methodology for the detection of treatment side effects. Papers I, II, both based in the population based cohort ULSAM (Uppsala Longitudin

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29

Min, Junxia. "Sphingolipid metabolic enzymes modulate anticancer drug resistance." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5899.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (March 5, 2007) Vita. Includes bibliographical references.

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30

Bai, Shuang. "Effect of immunosuppressive agents on drug metabolism in rats." Thesis, Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008270.

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31

Guest, Eleanor. "Assessment of algorithms for the prediction of metabolic drug-drug interactions." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/assessment-of-algorithms-for-the-prediction-of-metabolic-drugdrug-interactions(591ca23c-c75d-445e-a786-9b67689f9cd4).html.

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The aim of this work was to assess the ability of the static and dynamic (incorporating the time-course of the inhibitor) prediction models to predict drug-drug interactions (DDIs) using a population-based ADME simulator (Simcyp). This analysis focused on fluconazole, ketoconazole, itraconazole, fluoxetine and fluvoxamine, as CYP inhibitors. The rationale for their selection was an abundance of reported DDI studies, involving a wide range of victim drugs. Preliminary analysis focused on the individual victim drug and inhibitor parameters that are utilised in the DDI prediction models. The vict

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32

Macintyre, Fiona. "Cyclosporine and drug metabolism." Thesis, University of Aberdeen, 1988. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU526525.

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Cyclosporine (CsA) (50mg/kg daily) for 0 - 14 days caused reductions in cytochrome p-450-dependent monooxygenase activities, phase II drug metabolising enzyme activities and non-drug metabolising enzyme activities in male Sprague-Dawley rats, which appeared to be self-limiting. The chronologies and extents of these reductions varied. Decreased monooxygenase activities were accompanied by decreased NADPH-cytochrome c-reductase activities. No isozyme-specific effect was evident and there was no direct correlation of drug metabolising activities with nephrotoxicity (which was progressive). The wi

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33

Britt, Adrian John. "Cocaine metabolism in Pseudomonas maltophilia MB11L." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386328.

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34

王漪雯 and Belinda Wong. "Haloperidol metabolism in man and animals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B3121194X.

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Wong, Belinda. "Haloperidol metabolism in man and animals /." [Hong Kong] : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13671546.

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36

Daneshmend, T. K. "Observations on presystemic metabolism of drugs in man." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.482894.

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Huichalaf, Carbonell Mariela [Verfasser], and Stefan [Akademischer Betreuer] Wölfl. "Metabolic Profiling of Cancer Cells and Correlations between Metabolism, Gene Expression and Drug Sensitivity / Mariela Huichalaf Carbonell ; Betreuer: Stefan Wölfl." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177383950/34.

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Yang, Jiansong. "Quantitative prediction of metabolic drug-drug interactions : in vitro - in vivo extrapolation." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422638.

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39

Sek, Leab 1973. "An in vitro model of lipid digestion for assessing the oral bioavailability enhancement potential of lipidic formulations." Monash University, Dept. of Pharmaceutics, 2002. http://arrow.monash.edu.au/hdl/1959.1/8215.

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Priston, Melanie Jane. "Studies on the pharmacokinetics and metabolism of mitozantrone." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303766.

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41

Atsriku, Christian. "Analytical and metabolic studies of the trypanocidal diamidines." Thesis, University of Strathclyde, 2002. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21198.

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Following the expiry of patent protection of the innovator product Berenil®, there has been an influx of substandard generic substitutes of the veterinary trypanocide in international commerce, which have been implicated as being a major contributor to the emergence of drug resistance. This situation has necessitated the development of analytical techniques, which would help safeguard the quality and efficacy of generic formulations of diminazene. A selective, accurate, precise and simple reverse-phase isocratic HPLC method for the simultaneous assay of diminazene aceturate and antipyrine (exc

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42

Pereira, Maria J. "Effects of immunosuppressive drugs on human adipose tissue metabolism." Doctoral thesis, University of Gothenburg, 2012. http://hdl.handle.net/10400.1/4916.

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Tese de doutoramento, Philosophy (Medicine), Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Sahlgrenska Academy, 2012<br>The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious longterm metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. The overall aim is to study the effects of IAs on

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43

Richards, Jamie. "Investigation of metabolic pathways suitable for antimicrobial drug discovery." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424092.

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44

Bajpai, Manoj. "Metabolic isozymes of phenytoin and their roles in its drug interactions /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/7961.

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Godwin, Bryan. "Discrete sliding mode control of drug infusions." Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/16806.

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Coller, Janet K. "The Influence of the CYP2C19 and CYP2D6 genetic polymorphisms on oxidative drug metabolism." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phc6968.pdf.

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Amendements: leaves 252-254. Copies of author's previously published articles inserted. Bibliography: leaves 226-251. The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenyto

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47

Gill, Helen J. "Relationship between the metabolism and toxicity of sulphones and sulphonamides." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366003.

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48

Christensen, Magnus. "Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-522-0.

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49

Benchaoui, Hafid Abdelaali. "Factors affecting the pharmacokinetics, metabolism and efficacy of anthelmintic drugs." Thesis, University of Glasgow, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284569.

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Ngulube, Thabale Jack. "The interaction of anti-malarial drugs and steroid hormone metabolism." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329825.

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