Academic literature on the topic 'Metabolic oligosaccharide engineering'

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Journal articles on the topic "Metabolic oligosaccharide engineering"

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Gilormini, Pierre-André, Anna R. Batt, Matthew R. Pratt, and Christophe Biot. "Asking more from metabolic oligosaccharide engineering." Chemical Science 9, no. 39 (2018): 7585–95. http://dx.doi.org/10.1039/c8sc02241k.

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Metabolic Oligosaccharide Engineering (MOE) is a groundbreaking strategy which has been largely used in the last decades, as a powerful strategy for glycans understanding. The present review aims to highlight recent studies that are pushing the boundaries of MOE applications.
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Dube, D. "Metabolic oligosaccharide engineering as a tool for glycobiology." Current Opinion in Chemical Biology 7, no. 5 (2003): 616–25. http://dx.doi.org/10.1016/j.cbpa.2003.08.006.

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Campbell, Christopher T., Srinivasa-Gopalan Sampathkumar, and Kevin J. Yarema. "Metabolic oligosaccharide engineering: perspectives, applications, and future directions." Molecular BioSystems 3, no. 3 (2007): 187. http://dx.doi.org/10.1039/b614939c.

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Whitman, Chad M., Fan Yang, and Jennifer J. Kohler. "Modified GM3 gangliosides produced by metabolic oligosaccharide engineering." Bioorganic & Medicinal Chemistry Letters 21, no. 17 (2011): 5006–10. http://dx.doi.org/10.1016/j.bmcl.2011.04.128.

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Zheng, Xiu-Jing, Fan Yang, Mingwei Zheng, Chang-Xin Huo, Ye Zhang, and Xin-Shan Ye. "Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen." Organic & Biomolecular Chemistry 13, no. 22 (2015): 6399–406. http://dx.doi.org/10.1039/c5ob00405e.

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Möller, Heinz, Verena Böhrsch, Joachim Bentrop, Judith Bender, Stephan Hinderlich, and Christian P. R. Hackenberger. "Glycan-Specific Metabolic Oligosaccharide Engineering of C7-Substituted Sialic Acids." Angewandte Chemie International Edition 51, no. 24 (2012): 5986–90. http://dx.doi.org/10.1002/anie.201108809.

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Almaraz, Ruben T., Mohit P. Mathew, Elaine Tan, and Kevin J. Yarema. "Metabolic Oligosaccharide Engineering: Implications for Selectin-Mediated Adhesion and Leukocyte Extravasation." Annals of Biomedical Engineering 40, no. 4 (2011): 806–15. http://dx.doi.org/10.1007/s10439-011-0450-y.

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Späte, Anne-Katrin, Verena F. Schart, Sophie Schöllkopf, Andrea Niederwieser, and Valentin Wittmann. "Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering." Chemistry - A European Journal 20, no. 50 (2014): 16502–8. http://dx.doi.org/10.1002/chem.201404716.

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Späte, Anne-Katrin, Verena F. Schart, Sophie Schöllkopf, Andrea Niederwieser, and Valentin Wittmann. "Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering." Chemistry - A European Journal 20, no. 50 (2014): 16411. http://dx.doi.org/10.1002/chem.201405618.

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Ruffing, Anne, Zichao Mao, and Rachel Ruizhen Chen. "Metabolic engineering of Agrobacterium sp. for UDP-galactose regeneration and oligosaccharide synthesis." Metabolic Engineering 8, no. 5 (2006): 465–73. http://dx.doi.org/10.1016/j.ymben.2006.05.004.

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Dissertations / Theses on the topic "Metabolic oligosaccharide engineering"

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Ruffing, Anne M. "Metabolic engineering and omics analysis of Agrobacterium sp. ATCC 31749 for oligosaccharide synthesis." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39507.

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Oligosaccharides are important biomolecules that are targets and also components of many medical treatments, including treatments for cancer, HIV, and inflammation. While the demand for medically-relevant oligosaccharides is increasing, these compounds have proven difficult to synthesize. Whole-cell oligosaccharide synthesis is a promising method that requires relatively inexpensive substrates and can complete the synthesis in just one step. However, whole-cell oligosaccharide synthesis employing common microorganisms like E. coli have been plagued by low yields. This dissertation investigates
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Richard, Emeline. "Synthèse par ingénierie métabolique d'oligosaccharides sialylés pour l'élaboration de glycoconjugués d'intérêt médical." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV007/document.

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Les structures sialylées sont présentes à la surface des cellules sous forme de glycoconjugués,couplés à des protéines ou des lipides. Ces structures jouent un rôle important dans divers processusbiologiques que ce soit à travers l’interaction avec des lectines, ou de par leurs propriétés physicochimiques.Ces structures sont également impliquées dans diverses pathologies et on constatenotamment une forte augmentation du taux d’acides sialiques chez les individus atteints de cancer,due à une surexpession de structures naturelles mais aussi à l’apparition de nouveaux motifs,naturellement absent
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Vivier, Maxant. "Production in vitro et in cellulo d'oligosaccharides pour la santé humaine." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2025. http://www.theses.fr/2025TLSEI005.

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Les glycosides sont omniprésents dans la nature et remplissent des rôles fondamentaux pour le métabolisme et les interactions cellulaires. Certains d’entre eux sont des motifs antigéniques, comme les β-1,2-mannosides que l'on trouve à la surface de certaines espèces de levures du genre Candida, un pathogène fongique d’importance majeure selon l'Organisation Mondiale de la Santé. Grâce à leurs propriétés immunogènes, les β-1,2-mannosides présentent un fort potentiel pour le développement de produits préventifs, diagnostiques et curatifs des candidoses. L'objectif de ce travail de thèse était d'
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Cao, Te. "Metabolic Engineering of Raffinose-Family Oligosaccharides in the Phloem Reveals Alterations in Patterns of Carbon Partitioning and Enhances Resistance to Green Peach Aphid." Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc30441/.

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Phloem transport is along hydrostatic pressure gradients generated by differences in solute concentration between source and sink tissues. Numerous species accumulate raffinose-family oligosaccharides (RFOs) in the phloem of mature leaves to accentuate the pressure gradient between source and sinks. In this study, metabolic engineering was used to generate RFOs at the inception of the translocation stream of Arabidopsis thaliana, which transports predominantly sucrose. To do this, three genes, GALACTINOL SYNTHASE, RAFFINOSE SYNTHASE and STACHYOSE SYNTHASE, were expressed from promoters specifi
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Bastide, Ludovic. "Synthèse de glycannes sulfatés par le procédé d'"usine cellulaire"." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00600595.

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La partie oligosaccharidique des glycoconjugués, présents à la surface des cellules eucaryotes, intervient dans de nombreux processus biologiques de reconnaissance et d'adhésion cellulaire. L'essor de la glycobiologie au cours des vingt dernières années a permis de définir, à partir de l'implication de ces structures glycaniques, de nombreuses applications thérapeutiques potentielles. Cependant la fabrication de nouveaux médicaments à partir d'oligosaccharidiques requiert leur disponibilité en grande quantité mais leurs obtentions par purification ou par méthode de synthèse chimique et enzymat
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Rodrigues, Inês Alexandra Figueiredo. "Metabolic oligosaccharide engineering applied to neural stem cells." Master's thesis, 2012. http://hdl.handle.net/10451/7989.

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Tese de mestrado em Química (Química, Saúde e Nutrição), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012<br>Metabolic oligosaccharide engineering (MOE) permits the introduction of subtle modifications into monosaccharides residues within cellular glycans. The first landmark in the development of this technique started in its application for the study of sialic acid biology. This sugar has a rather privileged role in vertebrate biology as it is often at the capping position of cell surface glycans and is therefore exposed for interactions with exogenous cells and pr
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Kitowski, Annabel Katharina. "Bio-orthogonal site-selective labelling of carbohydrates and proteins." Doctoral thesis, 2019. http://hdl.handle.net/10451/44169.

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Carbohydrates and proteins represent two large groups of biomolecules which are tremendously important for biological processes in health and disease state. Although protein-structures are encoded in the genome, cellular glycan structures are template independent and can only be addressed in an indirect manner. The development of metabolic oligosaccharide engineering (MOE) gave rise to new methods to study carbohydrate structures in the context of different disease settings and in different organisms. While in many cases mannose derivatives are used to study the sialic acid structures in cance
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Book chapters on the topic "Metabolic oligosaccharide engineering"

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Aich, Udayanath, and Kevin J. Yarema. "Non-Natural Sugar Analogues: Chemical Probes for Metabolic Oligosaccharide Engineering Metabolic engineering Non-natural sugar Glycosylation pathways Mucins O-GlcNAc protein modification Chemoselective ligation." In Glycoscience. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-30429-6_55.

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Zúñiga, Manuel, María Jesús Yebra, and Vicente Monedero. "Complex Oligosaccharide Utilization Pathways in Lactobacillus." In Lactobacillus Genomics and Metabolic Engineering. Caister Academic Press, 2019. http://dx.doi.org/10.21775/9781910190890.03.

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Sidhu, Jiwan S., and Tasleem A. Zafar. "Functional Foods of the Indian Subcontinent." In Advances in Environmental Engineering and Green Technologies. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0591-4.ch016.

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The medicinal effects of food have been recognized on the Indian subcontinent since many centuries. The current thinking on functional foods can easily be applied to many traditional Indian subcontinent foods as these are based on whole grains, legumes, oilseeds, nuts, vegetables, fruits, spices, condiments, and many fermented milk products. Consumption of such foods on a regular basis not only provides most of nutrients in adequate quantities but also improve gastrointestinal health, boost immune functions, improve bone health, lower cholesterol, oxidative stress, reduce the risk of cardiovas
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Conference papers on the topic "Metabolic oligosaccharide engineering"

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Smith, Robert Lane. "Mechanical Loading and Articular Cartilage Metabolism." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2520.

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Abstract Articular cartilage provides diarthrodial joints with a loading-bearing surface that ensures functional motility. The physical characteristics of articular cartilage originate with the highly organized matrix of extracellular macromolecules that provide structural elements to the tissue. The matrix specialization rests with specific proteins produced by the cartilage cells, the chondrocytes that undergo extensive post-translational modification through addition of sulfated glycosaminoglycan and oligosaccharides. The matrix proteins fall into three major categories, the collagens, the
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Reports on the topic "Metabolic oligosaccharide engineering"

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Eyal, Yoram, Gloria Moore, and Efraim Lewinsohn. Study and Manipulation of the Flavanoid Biosynthetic Pathway in Citrus for Flavor Engineering and Seedless Fruit. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7570547.bard.

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The proposal was aimed to identify and functionally characterize key genes/enzymes in the citrus flavanone neohesperidoside biosynthetic pathway and to use them as tools for metabolic engineering to decrease bitterness levels in grapefruit. The proposed section on fruit seediness was dropped as suggested by the reviewers of the proposal. Citrus flavor and aroma is composed of complex combinations of soluble and volatile compounds. The former includes mainly sugars, acids and flavanones, a subgroup of flavonoids that includes bitter compounds responsible for the bitter flavor of grapefruit and
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