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Journal articles on the topic 'Metabolic orientation'

Author: Grafiati

Published: 1 June 2024

Last updated: 31 July 2025

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1

Larina, V., and D. Karpenko. "The metabolic and cytoprotective orientation of meldonium in multimorbidity." Vrach 33, no. 4 (2022): 56–62. http://dx.doi.org/10.29296/25877305-2022-04-08.

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Larina, V., and D. Karpenko. "The metabolic and cytoprotective orientation of meldonium in multimorbidity." Vrach 33, no. 4 (2022): 56–62. http://dx.doi.org/10.29296/25877305-2022-04-08.

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Noghabi, Ali Delshad. "Psychological Factors of Metabolic Syndrome." Journal of Biomedical Research & Environmental Sciences 2, no. 7 (2021): 641–43. http://dx.doi.org/10.37871/jbres1290.

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Several factors are involved in the etiology of metabolic syndrome, the most important of which are insulin resistance, obesity (especially abdominal obesity), lipid abnormalities, impaired glucose tolerance, hypertension, pre-inflammatory status, genetic factors, unhealthy lifestyle, trend Rapid urbanization, nutritional factors, inactivity, smoking and hookah smoking, social, economic and cultural factors, level of education, psychosocial stresses and environmental pollution. But psychological factors such as meta-cognitive beliefs, life orientation (optimism, pessimism) and positive and neg

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Ali, Delshad Noghabi. "Psychological Factors of Metabolic Syndrome." Journal of Biomedical Research & Environmental Sciences 2, no. 7 (2021): 641–43. https://doi.org/10.37871/jbres1290.

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Several factors are involved in the etiology of metabolic syndrome, the most important of which are insulin resistance, obesity (especially abdominal obesity), lipid abnormalities, impaired glucose tolerance, hypertension, pre-inflammatory status, genetic factors, unhealthy lifestyle, trend Rapid urbanization, nutritional factors, inactivity, smoking and hookah smoking, social, economic and cultural factors, level of education, psychosocial stresses and environmental pollution. But psychological factors such as meta-cognitive beliefs, life orientation (optimism, pessimism) and positive and neg

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Chen, Valerie, Antonio E. Bruno, Laura L. Britt, et al. "Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2." Journal of Biological Chemistry 295, no. 48 (2020): 16370–79. http://dx.doi.org/10.1074/jbc.ra120.015482.

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The melanocortin receptor accessory protein 2 (MRAP2) plays a pivotal role in the regulation of several G protein–coupled receptors that are essential for energy balance and food intake. MRAP2 loss-of-function results in obesity in mammals. MRAP2 and its homolog MRAP1 have an unusual membrane topology and are the only known eukaryotic proteins that thread into the membrane in both orientations. In this study, we demonstrate that the conserved polybasic motif that dictates the membrane topology and dimerization of MRAP1 does not control the membrane orientation and dimerization of MRAP2. We als

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Collorone, Sara, Ferran Prados, Baris Kanber, et al. "Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event." Brain 144, no. 5 (2021): 1409–21. http://dx.doi.org/10.1093/brain/awab043.

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Abstract In early multiple sclerosis, a clearer understanding of normal-brain tissue microstructural and metabolic abnormalities will provide valuable insights into its pathophysiology. We used multi-parametric quantitative MRI to detect alterations in brain tissues of patients with their first demyelinating episode. We acquired neurite orientation dispersion and density imaging [to investigate morphology of neurites (dendrites and axons)] and 23Na MRI (to estimate total sodium concentration, a reflection of underlying changes in metabolic function). In this cross-sectional study, we enrolled

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Kuzin, A., A. Khrebtova, O. Camerer, and E. Bykov. "ASSOCIATIVE DETERMINANTS OF THE TROPHOLOGICAL STATUS IN ATHLETES FROM AEROBIC AND ANAEROBIC SPORTS." Human Sport Medicine 20, no. 3 (2020): 51–63. http://dx.doi.org/10.14529/hsm200306.

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Aim. The paper aims to elaborate effectiveness criteria for aerobic and anaerobic training based on a comprehensive analysis of the athletes’ trophological status. Materials and methods. Anthropometric data, body composition, carbohydrate and fat metabolism indicators were collected for trained athletes (n = 41) once per day (in the morning) on an empty stomach. To find metabolic determinants for the training process of various orientations, athletes were divided into two groups, namely, a group with a predominantly aerobic orientation (n = 23) and those with a predominantly anaerobic one (n =

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Yang, Dan, Yifan Yang, Yanlin Li, and Rui Han. "Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation." Annals of Nutrition and Metabolism 74, no. 4 (2019): 313–21. http://dx.doi.org/10.1159/000500110.

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Background: Exercise therapy plays an important role in the prevention and treatment of type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of glycolipid metabolism of T2DM is very complex and not completely clear. Summary: Exercise training improves the whole body metabolic health in patients with T2DM, leading to an increase in glycolipid uptake and utilization, improved insulin sensitivity, optimized body mass index, and modulated DNA methylation, etc. Recent findings support that some cytokines such as irisin, osteocalcin, and adiponectin are closely related to exe

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Vanduffel, Wim, Erik Vandenbussche, Wolf Singer, and Guy A. Orban. "A Metabolic Mapping Study of Orientation Discrimination and Detection Tasks in the Cat." European Journal of Neuroscience 9, no. 6 (1997): 1314–28. http://dx.doi.org/10.1111/j.1460-9568.1997.tb01486.x.

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梅, 思源. "The Ecospatial Orientation of Marx’s Theory of Metabolic Rupture and Its Contemporary Value." Advances in Philosophy 13, no. 10 (2024): 2524–30. http://dx.doi.org/10.12677/acpp.2024.1310375.

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Orre, Charlotte, Xavier Dieu, Jordan Guillon, et al. "The Long Non-Coding RNA SAMMSON Is a Regulator of Chemosensitivity and Metabolic Orientation in MCF-7 Doxorubicin-Resistant Breast Cancer Cells." Biology 10, no. 11 (2021): 1156. http://dx.doi.org/10.3390/biology10111156.

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Despite improvements in therapeutic strategies for treating breast cancers, tumor relapse and chemoresistance remain major issues in patient outcomes. Indeed, cancer cells display a metabolic plasticity allowing a quick adaptation to the tumoral microenvironment and to cellular stresses induced by chemotherapy. Recently, long non-coding RNA molecules (lncRNAs) have emerged as important regulators of cellular metabolic orientation. In the present study, we addressed the role of the long non-coding RNA molecule (lncRNA) SAMMSON on the metabolic reprogramming and chemoresistance of MCF-7 breast c

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Chang, Yi-Min, Chia-Lin Lee, and Jun-Sing Wang. "Sex Disparity in the Association of Metabolic Syndrome with Cognitive Impairment." Journal of Clinical Medicine 13, no. 9 (2024): 2571. http://dx.doi.org/10.3390/jcm13092571.

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Background/Objectives: Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank. Methods: We determined the associations of MS and its five components with cognitive impairment (mini-mental state examination, MMSE < 24) and the five domains of MMSE using logistic regression analyses. Results: A total of 7399 men and 11,546 women were included, and MS was significantly associated with cognitive impairment only in women (adjusted OR 1.

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Karadsheh, Rama, Megan E. Meuser, and Simon Cocklin. "Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability." Molecules 25, no. 6 (2020): 1430. http://dx.doi.org/10.3390/molecules25061430.

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Fostemsavir/temsavir is an investigational HIV-1 entry inhibitor currently in late-stage clinical trials. Although it holds promise to be a first-in-class Env-targeted entry inhibitor for the clinic, issues with bioavailability relegate its use to salvage therapies only. As such, the development of a small molecule HIV-1 entry inhibitor that can be used in standard combination antiretroviral therapy (cART) remains a longstanding goal for the field. We previously demonstrated the ability of extending the chemotypes available to this class of inhibitor as the first step towards this overarching

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Sapir, Nir, and Robert Dudley. "Implications of floral orientation for flight kinematics and metabolic expenditure of hover-feeding hummingbirds." Functional Ecology 27, no. 1 (2012): 227–35. http://dx.doi.org/10.1111/1365-2435.12024.

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Zueva, I. B., D. S. Krivonosov, E. L. Urumova, A. V. Butch, A. Y. Smirnova, and E. R. Baranzevich. "Inflammation and cognitive function in patients with metabolic syndrome." Regional blood circulation and microcirculation 16, no. 1 (2017): 38–42. http://dx.doi.org/10.24884/1682-6655-2017-16-1-38-42.

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The purpose of this study was to explore the relationship between the level of C-reactive protein and fibrinogen, and indices of cognitive function in patients with metabolic syndrome. As a result of this study, it was demonstrated that patients with metabolic syndrome and cognitive impairment compared with the group without cognitive disorders was higher parameters of inflammation. The increase in C-reactive protein was associated with reduced memory and increased speed of reaction and ability to concentrate, whereas an increase in fibrinogen levels was associated with lower indicators of the

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Ferrari, Elís Domingos, Bruno César Miranda Oliveira, Hannah N. Creasey, et al. "The Impact of Physical Effort on the Gut Microbiota of Long-Distance Fliers." Microorganisms 11, no. 7 (2023): 1766. http://dx.doi.org/10.3390/microorganisms11071766.

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Flying pigeons (Columbia livia) are extensively studied for their physical endurance and superior sense of orientation. The extreme physical endurance of which these birds are capable creates a unique opportunity to investigate the possible impact of long-distance flying on the taxonomy and metabolic function of the gut microbiota. This project was enabled by access to two groups of pigeons raised by the same breeder in the same conditions, except that one group was trained in long-distance flying and participated in multiple races covering a total distance of over 2600 km over a 9-week period

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Вагин, Yu Vagin, Фудин, N. Fudin, Пигарева, and S. Pigareva. "System Fatigue Mechanisms at Exercises of Circular Orientation." Journal of New Medical Technologies 21, no. 3 (2014): 118–22. http://dx.doi.org/10.12737/5915.

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Mechanisms of fatigue during exercise of circular orientation of various volume and intensity are analyzed from the position of functional systems theory. Peculiarities of fatigue anaerobic metabolism in high-speed sports, aerobic-anaerobic metabolism in sports disciplines connected with high speed endurance and aerobic metabolism in running the long and very long distances are considered. Sprint is dominated by anaerobic processes in working skeletal muscles and central mechanisms of fatigue. Central fatigue is ahead of peripheral fatigue of neuromuscular system. Anaerobic and aerobic oxidati

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Ghetti, Fabiana De Faria, Daiane Gonçalves De Oliveira, Juliano Machado De Oliveira, Lincoln Eduardo Villela Vieira de Castro Ferreira, Dionéia Evangelista Cesar, and Ana Paula Boroni Moreira. "Effects of Dietary Intervention on Gut Microbiota and Metabolic-Nutritional Profile of Outpatients with Non-Alcoholic Steatohepatitis: a Randomized Clinical Trial." Journal of Gastrointestinal and Liver Diseases 28, no. 3 (2019): 279–87. http://dx.doi.org/10.15403/jgld-197.

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Background & Aims: Modulation of the gut microbiota emerges as a therapeutic possibility to improve health. Our objective was to compare the impact of three months of intervention with diet plus nutritional orientation versus only nutritional orientation on the gut microbiota and metabolic-nutritional profile of outpatients with non-alcoholic steatohepatitis. Methods: It was a randomized clinical trial with 40 outpatients (49.48 ± 10.3 years), allocated in two groups: DIET group (n=20), who received diet (1.651.34 ± 263.25 kcal; 47% carbohydrates, 28% lipids, 25% proteins, 30 g fiber

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Олег Миколайович Мелащенко, Лев Михайлович Рижков, and А. М. Лукавий. "ASSESSING THE ACCURACY OF THE ANGULAR ORIENTATION OF THE MICROSATELLITE BY KALMAN UNDER UNCERTAINTY AND MEASUREMENT NOISE." MECHANICS OF GYROSCOPIC SYSTEMS, no. 27 (October 6, 2014): 26–33. http://dx.doi.org/10.20535/0203-377127201437914.

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At present, not enough attention is paid to the impact of uncertainty Earth's magnetic field, taking into account the errors of the sensor of the sun, setting errors inertia tensor microsatellite (MS) and noise measurements.This paper considers the problem of evaluating the accuracy of the angular orientation of the MS Kalman filter (FK) under uncertainty and measurement noise. Included instrumental errors and inaccurate meters mathematical model of MS.To solve this problem based simulation model of MS, where the mathematical tools used quaternion algebra. As of position sensors used magnetome

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Kaczmarz, Stephan, Jens Göttler, Claus Zimmer, Fahmeed Hyder, and Christine Preibisch. "Characterizing white matter fiber orientation effects on multi-parametric quantitative BOLD assessment of oxygen extraction fraction." Journal of Cerebral Blood Flow & Metabolism 40, no. 4 (2019): 760–74. http://dx.doi.org/10.1177/0271678x19839502.

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Relative oxygen extraction fraction (rOEF) is a fundamental indicator of cerebral metabolic function. An easily applicable method for magnetic resonance imaging (MRI) based rOEF mapping is the multi-parametric quantitative blood oxygenation level dependent (mq-BOLD) approach with separate acquisitions of transverse relaxation times [Formula: see text] and T2 and dynamic susceptibility contrast (DSC) based relative cerebral blood volume (rCBV). Given that transverse relaxation and rCBV in white matter (WM) strongly depend on nerve fiber orientation, mq-BOLD derived rOEF is expected to be affect

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Vieira, C. M., V. L. S. Chvatal, S. N. Cordeiro, and E. R. Turato. "Psychological life experiences facing chronic diseases for patients with metabolic syndrome and impacts reported about health promotion in the Southeast Brazil: A clinical qualitative study." European Psychiatry 26, S2 (2011): 737. http://dx.doi.org/10.1016/s0924-9338(11)72442-7.

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IntroductionReceiving and understanding the psychological and sociocultural aspects associated to both health problems and difficulties to make the eating behaviour changes are relevant issues when treating individuals with Metabolic Syndrome.Objective and aimsThe reports given by chronic individuals in the present study allowed for analyzing the subjective expressions related to food, treatment management and patient adherence to self care propositions.MethodsIn-depth semi-directed interviews with open-ended questions, with psychodynamic orientation in the conducting dialogues were performed

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Luft, V. M., A. E. Demko, B. R. Kelbetova, et al. "Problems of Nutritional and Metabolic Therapy of Patients with Intestinal Fistulas." Russian Sklifosovsky Journal "Emergency Medical Care" 14, no. 1 (2025): 155–65. https://doi.org/10.23934/2223-9022-2025-14-1-155-165.

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Intestinal fistulas remain a multidisciplinary, often life-threatening problem of clinical medicine. Such patients in the process of their conservative and surgical stages of treatment remain in a state of systemic metabolic dysfunction for a long time, which is usually accompanied by phenomena of trophological insufficiency of varying severity. In this regard, one of the most important areas of treatment for this category of patients is nutritional-metabolic therapy (NMT), aimed at minimizing the consequences, and, if possible, stopping the catabolic orientation of metabolism, which will help

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Bairy, Partha Sarathi. "PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA, AN EMERGING POTENTIAL TARGET TO COMBAT METABOLIC DISORDER." Asian Journal of Pharmaceutical and Clinical Research 10, no. 12 (2017): 40. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.21596.

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Day-by-day metabolic disorder/syndrome (MS) falling in love with current lifestyle status of everyone especially after study age group of people. If we look carefully around us, we will see evidence is growing up of diabetic, obese, and hypertensive population regularly. In urgencies of above view extensive literature survey has been done prioritizing prevalence of metabolic disorder and peroxisome proliferator-activated receptor-gamma (PPAR-γ) as potential target protein. This review covered current status of MS emphasizing diabetes along with its management criteria. Special importance is gi

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Klaassen, M. "Metabolic constraints on long-distance migration in birds." Journal of Experimental Biology 199, no. 1 (1996): 57–64. http://dx.doi.org/10.1242/jeb.199.1.57.

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The flight range of migrating birds depends crucially on the amount of fuel stored by the bird prior to migration or taken up en route at stop-over sites. However, an increase in body mass is associated with an increase in energetic costs, counteracting the benefit of fuel stores. Water imbalance, occurring when water loss exceeds metabolic water production, may constitute another less well recognised problem limiting flight range. The main route of water loss during flight is via the lungs; the rate of loss depends on ambient temperature, relative humidity and ventilatory flow and increases w

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Rabins, Peter V. "Psychosocial and Management Aspects of Delirium." International Psychogeriatrics 3, no. 2 (1991): 319–24. http://dx.doi.org/10.1017/s1041610291000765.

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Data to demonstrate that psychosocial factors, sensory deprivation, or sleep deprivation alone can cause delirium are few. Nonetheless, these factors or conditions may contribute to the development or symptom presentation of a delirium when other metabolic or toxic etiologies are present. There is likewise little research on the appropriate treatment of the delirious patient. Clinical experience suggests that attention to the patient's psychological state through frequent orientation, emotional support, and frequent explanation can help. Low-dose neuroleptic drugs are occasionally useful and n

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Grishina, Zh V., G. A. Makarova, S. A. Bazanovich, et al. "Hidden metabolic disorders in high-class athletes." Sports medicine: research and practice 10, no. 4 (2021): 64–75. http://dx.doi.org/10.47529/2223-2524.2020.4.3.

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Objective: to reveal the frequency of deviations occurrence in individual biochemical indicators, which can be markers of hidden metabolicconditioned deviations in the health of athletes.Materials and methods. Members of sports teams of Russia at the age of 16 to 38 years were examined. The total number of examined athletes was 5245: 3167 were male athletes and 2078 were female athletes. We studied 25 indicators of the biochemical composition of blood, showing latent metabolic disorders and the activity of its regulators, negative shifts in the functional state of individual physiological syst

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Yasmin, Sabina, Ndumiso N. Mhlongo, Mahmoud E. Soliman, Saraswathy GR та Venkatesan Jayaprakash. "Comparative Design, In Silico Dockingand Predictive ADME/ TOX Properties of Some Novel 2, 4-hydroxy Derivatives of Thiazolidine-2, 4-diones as PPARγ Modulator". JOURNAL OF PHARMACEUTICAL CHEMISTRY 4, № 2 (2017): 11–19. http://dx.doi.org/10.14805/jphchem.2017.art74.

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Peroxisome proliferated receptors (PPARs) are important targets for drugs used in the treatment of various metabolic disorders. We have reported 4-hydroxy benzylidene derivatives of thiazolidine-2,4-diones with reversed orientation in the active site of PPARγin our earlier communication. With the reversed conformation of TZD, fitting the established pharmacophore was discussed. The current simulation studies revolves around the 2,4-dihydroxy benzylidene derivatives expecting H-bonding interactions similar to Rosiglitazone’s acidic head. The docking protocol was validated by enrichment studies

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Niedermeyer, E. "The Clinical Relevance of EEG Interpretation." Clinical Electroencephalography 34, no. 3 (2003): 93–98. http://dx.doi.org/10.1177/155005940303400303.

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There is need nowadays to re-emphasize the capabilities of electroencephalography: a method representing the extremely important function/dysfunction-orientation in neurological thinking and practice. Valuable and relevant messages to the clinician naturally require solid EEG training and the resulting expertise. The idea that valuable EEG information is limited to the field of epileptology is erroneous. A plethora of clinically relevant messages can be derived from the EEG in nonepileptic conditions and, above all, in metabolic (and so called “mixed”) encephalopathies where neuroimaging has a

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Shilkar, Deepak, та Sabina Yasmin. "Molecular Docking Studies of Novel Thiazolidinedionederivatives as PPARγ Modulators". Journal of Pharmaceutical Chemistry 9 (14 грудня 2023): 12–21. http://dx.doi.org/10.14805/jphchem.2023.art124.

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Thiazolidinediones (TZDs), a well-known target of peroxisome proliferated receptors (PPARγ), have been clinically used as antidiabetic agents. PPARs belong to the nuclear receptor superfamily and are important targets (PPARs) for drugs that treat various metabolic disorders such as diabetes. We present comparative research on the meta-para substitution of benzylidene derivatives of thiazolidine-2,4-diones to identify their potential as modulators of PPARγ. PPARs are key drug targets in treating a range of metabolic disorders. In our previous study, we described 4-hydroxy benzylidene derivative

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Kopcewicz, Katarzyna A., Thomas W. O'Rourke, and Daniel Reines. "Metabolic Regulation of IMD2 Transcription and an Unusual DNA Element That Generates Short Transcripts." Molecular and Cellular Biology 27, no. 8 (2007): 2821–29. http://dx.doi.org/10.1128/mcb.02159-06.

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ABSTRACT Transcriptional regulation of IMD2 in yeast (Saccharomyces cerevisiae) is governed by the concentration of intracellular guanine nucleotide pools. The mechanism by which pool size is measured and transduced to the transcriptional apparatus is unknown. Here we show that DNA sequences surrounding the IMD2 initiation site constitute a repressive element (RE) involved in guanine regulation that contains a novel transcription-blocking activity. When this regulatory region is placed downstream of a heterologous promoter, short poly(A)+ transcripts are generated. The element is orientation d

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Sánchez-Pernaute, Andrés, Miguel Angel Rubio Herrera, Elia Pérez-Aguirre, Pablo Talavera, and Antonio J. Torres. "521 Single-Anastomosis Duodeno-Ileal Bypass With Sleeve Gastrectomy (SADI-S): A Simplified Duodenal Switch With Metabolic Orientation." Gastroenterology 142, no. 5 (2012): S—1027. http://dx.doi.org/10.1016/s0016-5085(12)63976-6.

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Ortega-Jimenez, Victor M., Nir Sapir, Marta Wolf, Evan A. Variano, and Robert Dudley. "Into turbulent air: size-dependent effects of von Kármán vortex streets on hummingbird flight kinematics and energetics." Proceedings of the Royal Society B: Biological Sciences 281, no. 1783 (2014): 20140180. http://dx.doi.org/10.1098/rspb.2014.0180.

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Animal fliers frequently move through a variety of perturbed flows during their daily aerial routines. However, the extent to which these perturbations influence flight control and energetic expenditure is essentially unknown. Here, we evaluate the kinematic and metabolic consequences of flight within variably sized vortex shedding flows using five Anna's hummingbirds feeding from an artificial flower in steady control flow and within vortex wakes produced behind vertical cylinders. Tests were conducted at three horizontal airspeeds (3, 6 and 9 m s −1 ) and using three different wake-generatin

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Vieira, Carla Maria, Vera Lúcia Soares Chvatal, Silvia Nogueira Cordeiro, and Egberto Ribeiro Turato. "Nutrition and self-care practices of patients with chronic Metabolic Syndrome: a qualitative study." Acta Paulista de Enfermagem 25, no. 4 (2012): 537–42. http://dx.doi.org/10.1590/s0103-21002012005000017.

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OBJECTIVE: To analyze subjective aspects of eating habits and self-care of patients living with chronic symptoms linked to metabolic syndrome. METHODS: A clinical and qualitative (exploratory, non-experimental) study, conducted with an intentionally small sample of nine patients in treatment at an outpatient endocrinology clinic of a university hospital in São Paulo, Brazil. The sample was closed when data saturation occurred. The in-depth interviews were conducted with a psychodynamic orientation toward the conduct of dialogues. The categorization of the discourse was developed through conten

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Rouquet, Géraldine, Gaëlle Porcheron, Claire Barra, et al. "A Metabolic Operon in Extraintestinal Pathogenic Escherichia coli Promotes Fitness under Stressful Conditions and Invasion of Eukaryotic Cells." Journal of Bacteriology 191, no. 13 (2009): 4427–40. http://dx.doi.org/10.1128/jb.00103-09.

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ABSTRACT We identified a carbohydrate metabolic operon (frz) that is highly associated with extraintestinal pathogenic Escherichia coli (ExPEC) strains. The frz operon codes for three subunits of a phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) transporter of the fructose subfamily, for a transcriptional activator of PTSs of the MgA family, for two type II ketose-1,6-bisphosphate aldolases, for a sugar-specific kinase (repressor, open reading frame, kinase family [ROK]), and for a protein of the cupin superfamily. We proved that the frz operon promotes bacterial fitness under

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Koshel, Ivanna. "Level of Arachidonic Acid and State of Peroxidation Processes in Patients with Aspirin-Intolerant Polypous Rhinosinusitis." Galician Medical Journal 23, no. 4 (2016): 2016410. http://dx.doi.org/10.21802/gmj.2016.4.10.

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The main peculiarity of aspirin-intolerant polypous rhinosinusitis pathogenesis is the presence of “genetic block” of constitutive cyclooxygenase being the key enzyme of the arachidonic acid metabolism. It justifies the necessity of studying its metabolic peculiarities.The objective of the research was to determine the level of arachidonic acid as well as the state of lipid and protein peroxidation processes in patients with aspirin-intolerant polypous rhinosinusitis.Materials and methods. The levels of arachidonic acid, malondialdehyde and oxidative modification of serum proteins were studied

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Flerchuk, Viktor, Vasyl Antonets, and Oleksandr Mozolyuk. "Determining the correlation between pedagogical tests and the result of total distances in kayaking." Scientific Journal of National Pedagogical Dragomanov University. Series 15. Scientific and pedagogical problems of physical culture (physical culture and sports), no. 9(154) (October 3, 2022): 114–18. http://dx.doi.org/10.31392/npu-nc.series15.2022.9(154).25.

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The article examines the relationship between pedagogical tests and sports results at competitive distances, in kayaking. A well-grounded complex of informative pedagogical tests has been developed, which should be used to orient athletes for competitive distances of 200, 500, 1000 m, and when building a training process at the stages of preliminary and specialized basic training. For sports orientation at the stage of specialized basic training in kayaking, tests are offered that have a high probability of correlation with sports results at competitive distances. To determine the ability of r

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Gunina, L. M., K. M. Milashius, A. A. Chernozub, S. I. Danylchenko, and V. L. Voitenko. "Improving the Training of Qualified Athletes-Students by Modern Nutritiological Technologies." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 5 (2021): 445–49. http://dx.doi.org/10.26693/jmbs06.05.445.

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Currently, a significant part of highly qualified athletes are students of higher educational institutions at the same time, which manifests itself not only in an ultra-high level of physical activity, but also in significant psycho-emotional stress. Therefore, the search and introduction of modern technologies in the process of sports training, including pharmacological, hygienic, rehabilitation, etc. are continuing. An essential place among such technologies is occupied by a comprehensive methodology of nutrition-metabolic support of the training process, built on the principles of evidence-

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Korchagina, Ya A., V. T. Dolgikh, O. V. Leonov, and A. V. Erschov. "NUTRIENT CORRECTION OF FUNCTIONAL AND METABOLIC DISORDERS IN CHILDREN WITH CEREBRAL MEDULLOBLASTOMA." Russian Journal of Oncology 22, no. 2 (2017): 66–71. http://dx.doi.org/10.18821/1028-9984-2017-22-2-66-71.

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The goal is to assess the effectiveness of the use of nutritional support in children with medulloblastoma after surgical treatment and standard radiotherapy. Material and methods. We examined and treated 80 children with cerebellar medulloblastoma, aged of from 6 to 16 years. The treatment was complete surgical removal of the tumor with subsequent chemoradiation therapy (40 children) and nutritional support in the form of isocaloric mixture Nutricomp Standard Liquid (40 children). Hematological and biochemical indices were evaluated before and after treatment for 60 days. Results. There were

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Schmid, Micaela, and Marco Schieppati. "Neck muscle fatigue and spatial orientation during stepping in place in humans." Journal of Applied Physiology 99, no. 1 (2005): 141–53. http://dx.doi.org/10.1152/japplphysiol.00494.2004.

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Neck proprioceptive input, as elicited by muscle vibration, can produce destabilizing effects on stance and locomotion. Neck muscle fatigue produces destabilizing effects on stance, too. Our aim was to assess whether neck muscle fatigue can also perturb the orientation in space during a walking task. Direction and amplitude of the path covered during stepping in place were measured in 10 blindfolded subjects, who performed five 30-s stepping trials before and after a 5-min period of isometric dorsal neck muscle contraction against a load. Neck muscle electromyogram amplitude and median frequen

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Vasilenko, Vladimir S., Evgeniya S. Semenova, and Yuliya B. Semenova. "Blood lipids in athletes depending on the orientation of the training process." Pediatrician (St. Petersburg) 8, no. 2 (2017): 10–14. http://dx.doi.org/10.17816/ped8210-14.

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Sports form the metabolic response caused by the body’s adaptation to increased physical stress, which leads to the restructuring of metabolism for energy and plastic maintenance of sport activities. The restructuring of carbohydrate and lipid metabolism is caused primarily by the increasing energy request body, depending on type and intensity of sports activity. In this research blood serum lipids were studied depending on the orientation of the training process. A total of 108 athletes (men and women) aged 15 to 20 years of different sports qualification (I sports category, Candidate Master

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Rincón-Limas, D. E., D. A. Krueger, and P. I. Patel. "Functional characterization of the human hypoxanthine phosphoribosyltransferase gene promoter: evidence for a negative regulatory element." Molecular and Cellular Biology 11, no. 8 (1991): 4157–64. http://dx.doi.org/10.1128/mcb.11.8.4157-4164.1991.

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The enzyme hypoxanthine phosphoribosyltransferase (HPRT) catalyzes the metabolic salvage of the purine bases hypoxanthine and guanine. We previously characterized the genomic structure of the human HPRT gene and described its promoter sequence. In this report, we identify cis-acting transcriptional control regions of the human HPRT gene by linking various 5'-flanking sequences to the bacterial chloramphenicol acetyltransferase gene. The sequence from positions -219 to -122 relative to the translation initiation site is required for maximal expression of this gene, and it functions equally in b

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Rincón-Limas, D. E., D. A. Krueger, and P. I. Patel. "Functional characterization of the human hypoxanthine phosphoribosyltransferase gene promoter: evidence for a negative regulatory element." Molecular and Cellular Biology 11, no. 8 (1991): 4157–64. http://dx.doi.org/10.1128/mcb.11.8.4157.

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The enzyme hypoxanthine phosphoribosyltransferase (HPRT) catalyzes the metabolic salvage of the purine bases hypoxanthine and guanine. We previously characterized the genomic structure of the human HPRT gene and described its promoter sequence. In this report, we identify cis-acting transcriptional control regions of the human HPRT gene by linking various 5'-flanking sequences to the bacterial chloramphenicol acetyltransferase gene. The sequence from positions -219 to -122 relative to the translation initiation site is required for maximal expression of this gene, and it functions equally in b

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Zhang, Ran, Huizhen Hu, Youmei Wang, et al. "A novel rice fragile culm 24 mutant encodes a UDP-glucose epimerase that affects cell wall properties and photosynthesis." Journal of Experimental Botany 71, no. 10 (2020): 2956–69. http://dx.doi.org/10.1093/jxb/eraa044.

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Abstract UDP-glucose epimerases (UGEs) are essential enzymes for catalysing the conversion of UDP-glucose (UDP-Glc) into UDP-galactose (UDP-Gal). Although UDP-Gal has been well studied as the substrate for the biosynthesis of carbohydrates, glycolipids, and glycoproteins, much remains unknown about the biological function of UGEs in plants. In this study, we selected a novel rice fragile culm 24 (Osfc24) mutant and identified it as a nonsense mutation of the FC24/OsUGE2 gene. The Osfc24 mutant shows a brittleness phenotype with significantly altered cell wall composition and disrupted orientat

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de Siqueira, Lilian, Nilza Ribeiro, Maria B. A. Paredes, et al. "Influence of PLLA/PCL/HA Scaffold Fiber Orientation on Mechanical Properties and Osteoblast Behavior." Materials 12, no. 23 (2019): 3879. http://dx.doi.org/10.3390/ma12233879.

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Scaffolds based on aligned and non-aligned poly (L-lactic acid) (PLLA)/polycaprolactone (PCL) fibers obtained by electrospinning, associated to electrosprayed hydroxyapatite (HA) for tissue engineering applications were developed and their performance was compared in terms of their morphology and biological and mechanical behaviors. The morphological results assessed by scanning electron microscopy showed a mesh of PLLA/PCL fibers (random and perfectly aligned) associated with aggregates of nanophased HA. Fourier transform infrared spectrometry confirmed the homogeneity in the blends and the p

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Dzampaeva, Zh V., F. S. Datieva, E. A. Takoeva, and M. I. Nartikoeva. "Prevention and correction of behavioral disorders in rats with metabolic syndrome using a complex phytoadaptogen." Acta Biomedica Scientifica 9, no. 1 (2024): 233–40. http://dx.doi.org/10.29413/abs.2024-9.1.23.

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The aim of the study. To assess the possibility of correction and prevention of behavioral disorders in rats with metabolic syndrome using a complex phytoadaptogen (CPA).Material and methods. The experiment was carried out on 30 male Wistar rats randomized into 3 groups: group 1 – control; group 2 – metabolic syndrome (MS); group 3 – treatment of metabolic syndrome using CPA. In groups 2 and 3, animals were on a high-carbohydrate and high-fat diet for 16 weeks. Group 3 received CPA for 14 days in drinking water after 16 weeks of a diet. CPA consists of official tinctures of Glycyrrhiza glabra,

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Knysh, O. V., O. Y. Isayenko, O. V. Falko, et al. "Cellular metabolic activity as a marker of cytotoxicity and immunotropicity of probiotics’ derivatives." Regulatory Mechanisms in Biosystems 9, no. 2 (2018): 223–28. http://dx.doi.org/10.15421/021833.

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Structural components of cells and metabolites of probiotics with biologically active potential, along with the study of effectiveness, require a series of tests to ensure their safety. The study aims to test the cytotoxicity and potential of structural and metabolic derivatives of Bifidobacterium bifidum and Lactobacillus reuteri to affect the immunocompetent cells using in vitro tests that characterize the metabolic activity of test-cells. Structural components of probiotic bacteria were obtained by the physical method of disintegration – cyclic freezing-thawing. Metabolic derivatives were o

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Feng, Xianmin, Chunlin Yang, Wenyu Zheng, and Jianfan Wen. "Structural and evolutionary characteristics of pyruvate phosphate dikinase in Giardia lamblia and other amitochondriate protozoa." Chinese Medical Journal 127, no. 23 (2014): 4097–103. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20141864.

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Background Pyruvate phosphate dikinase (PPDK) reversibly catalyzes the interconversion of phosphoenolpyruvate (PEP) and pyruvic acid, leading to catabolism and adenosine triphosphate (ATP) synthesis or gluconeogenesis and ATP consumption. Molecular modeling of PPDKs from divergent organisms demonstrates that the orientation of the phosphorylatable histidine residue within the central domain of PPDK determines whether this enzyme promotes catabolism or gluconeogenesis. The goal of this study was to determine whether PDDK from Giardia underwent adaptive evolution in order to produce more energy

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Levada, Kateryna, Alexander Omelyanchik, Valeria Rodionova, Ralf Weiskirchen, and Matthias Bartneck. "Magnetic-Assisted Treatment of Liver Fibrosis." Cells 8, no. 10 (2019): 1279. http://dx.doi.org/10.3390/cells8101279.

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Chronic liver injury can be induced by viruses, toxins, cellular activation, and metabolic dysregulation and can lead to liver fibrosis. Hepatic fibrosis still remains a major burden on the global health systems. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are considered the main cause of liver fibrosis. Hepatic stellate cells are key targets in antifibrotic treatment, but selective engagement of these cells is an unresolved issue. Current strategies for antifibrotic drugs, which are at the critical stage 3 clinical trials, target metabolic regulation, immu

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Abramova, L. S., and A. V. Kozin. "Assessment of the Nutrient and Metabolic Profile of the Chum Salmon (<i>Oncorhynchus keta</i>)." Прикладная биохимия и микробиология 60, no. 1 (2024): 90–100. http://dx.doi.org/10.31857/s0555109924010109.

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An analysis of the biological value of chum salmon showed that, in terms of the balance of the amino acid composition of the protein, chum salmon with spawning changes is not inferior to chum salmon without spawning changes (chum salmon “silver”). A higher content of polyunsaturated fatty acids in total lipids, including omega-3, was noted in chum salmon with spawning changes compared to chum salmon “silver”. The metabolic profile of chum salmon samples obtained by NMR spectroscopy showed that the levels of Asp, Glu and Glc markedly increase during spawning migration, which is explained by the

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Neil, Thomas R., and Graham N. Askew. "Swimming mechanics and propulsive efficiency in the chambered nautilus." Royal Society Open Science 5, no. 2 (2018): 170467. http://dx.doi.org/10.1098/rsos.170467.

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The chambered nautilus ( Nautilus pompilius ) encounters severe environmental hypoxia during diurnal vertical movements in the ocean. The metabolic cost of locomotion ( C met ) and swimming performance depend on how efficiently momentum is imparted to the water and how long on-board oxygen stores last. While propulsive efficiency is generally thought to be relatively low in jet propelled animals, the low C met in Nautilus indicates that this is not the case. We measured the wake structure in Nautilus during jet propulsion swimming, to determine their propulsive efficiency. Animals swam with ei

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