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Dissertations / Theses on the topic 'Metabolic P system'

Author: Grafiati

Published: 11 March 2023

Last updated: 19 July 2025

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1

McConn, Donavon J. "Metabolic and inhibitory differences between cytochromes P450 3A4 and 3A5 /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7980.

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2

Dai, Yang. "Impact of the CYP3A5 polymorphism on the metabolic disposition of calcineurin inhibitors /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/7935.

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3

Dickmann, Leslie J. "Characterization of CYP2C9 residues important for conferring substrate specificity and inter-individual variability in drug metabolism /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8184.

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4

Hutzler, James Matthew. "Factors affecting CYP2C9-mediated metabolism." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2204.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains viii, 199 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 176-195).

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5

Wennerholm, Agneta. "Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-697-9/.

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6

Wurden, Colleen J. "Metabolism of carbamazepine and inhibitory drug interactions /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/7977.

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7

Ayscue, Robyn Renee. "Computer modeling of dapsone-mediated heteroactivation of flurbiprofen metabolism by CYP2C9." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5642.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains viii, 174 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 164-174).

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8

O'Mahony, Brian. "Clinical and toxicological significance of the involvement of the cytocrhome p450 system in the metabolism of 3,4-methylenedioxymethamphetamine." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7209.

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La 3,4-metilenodioximetanfetamina (MDMA, éxtasis) es una anfetamina sustituida de consumo frecuente y abusivo. La enzima principal que participa en el metabolismo de fase I de la MDMA, la isoforma 2D6 (CYP2D6) del citocromo P450, resulta también inhibida por la MDMA. Además, ésta es a la vez metabolizada por otras isoformas de CYP, por ejemplo la CYP1A2. La contribución de esta enzima y los posibles cambios en su actividad tras una administración de MDMA nunca han sido estudiados in-vivo. En consecuencia, se realizó un ensayo clínico donde los marcadores, dextrometorfano y cafeína se administr

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9

Ufer, Mike. "The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9 /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-172-5/.

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10

Kabulski, Jarod L. "Development of Au-immobilized P450 platform for exploring the effect of oligomer formation on P450-mediated metabolism for In vitro to In vivo drug metabolism predictions." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/10892.

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Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains xiv, 180 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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11

Xu, Yang. "Regulation of intestinal CYP3A4 expression and metabolism of 1Alpha, 25-Dihydroxyvitamin D3 /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/7933.

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12

Sim, Sarah C. "Genetically determined interindividual variation in cytochrome P450 dependent drug metabolism : molecular basis and clinical implications /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-060-2/.

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13

Lin, Yvonne S. "Variability in CYP3A expression and metabolism : influence of genetics and probe substrate selection /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/7966.

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14

Niedenführ, Sebastian [Verfasser]. "Analyzing the fluxome of P. chrysogenum in an industrial environment : workflows for 13C metabolic flux analysis in complex systems / Sebastian Niedenführ." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1059536943/34.

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15

Bodin, Karl. "On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-769-X/.

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16

CASTELLINI, ALBERTO. "Algorithms and Software for Biological MP Modeling by Statistical and Optimization Techniques." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/342895.

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I sistemi biologici sono gruppi di entità biologiche (es. molecole ed organismi), che interagiscono producendo specifiche dinamiche. Questi sistemi sono solitamente caratterizzati da una elevata complessità perchè coinvolgono un elevato numero di componenti con molte interconnessioni. La comprensione dei meccanismi che governano i sistemi biologici e la previsione dei loro comportamenti in condizioni normali e patologiche è una sfida cruciale della biologia dei sistemi (in inglese detta systems biology), un'area di ricerca al confine tra biologia, medicina, matematica ed informatica. In que

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17

Afzelius, Lovisa. "Computational Modelling of Structures and Ligands of CYP2C9." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4016.

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18

Bartha, Bernadett [Verfasser], Peter [Akademischer Betreuer] Schröder, and Jürgen P. [Akademischer Betreuer] Geist. "Uptake and metabolism of human pharmaceuticals in plants : Identification of metabolites and specification of the defense enzyme systems under pharmaceutical exposure / Bernadett Bartha. Gutachter: Jürgen P. Geist. Betreuer: Peter Schröder." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1025337751/34.

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19

Ernstgård, Lena. "Uptake, disposition and acute effects of inhaled organic solvents : sex differences and influence of cytochrome P450 2E1 in human volunteers /." Stockholm : Karolinska inst, 2003. http://diss.kib.ki.se/2003/91-7349-657-X/.

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20

Stark, Katarina. "Catalytic Properties and Tissue Distribution of Cytochrome P450 4F8 and 4F12 : Expression of CYP4F8 in Eye Tissues and Psoriatic Lesions." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5731.

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21

PAGLIARINI, Roberto. "Modelling and Reverse-Engineering of Biological Phenomena by means of Metabolic P Systems." Doctoral thesis, 2011. http://hdl.handle.net/11562/350709.

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Le reti biologiche hanno un ruolo cruciale in ogni processo vitale: meccanismi di regolazione genetica, differenziazione cellulare, metabolismo, ciclo cellulare, e trasduzione intracellulare del segnale. Progressi nei metodi sperimentali hanno permesso studi su larga scala di queste reti e possono rivelare la loro logica. Di conseguenza, i biologi devono integrare grandi quantità di dati sperimentali a analizzare reti complesse. I modelli matematici sono strumenti essenziali per collegare i comportamenti di un sistema con le interazioni tra le sue componenti. Modelli di reti biochimiche posso

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22

"Metabolic activation of drugs and other xenobiotics in hepatocellular carcinoma." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5888230.

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Grace S.N. Lau.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1994.<br>Includes bibliographical references (leaves 335-362).<br>List of Abbreviations --- p.i<br>Abstract --- p.1<br>Chapter Chapter 1 --- General Introduction and Study Objectives<br>Chapter 1.1 --- Metabolic activation - role in drug toxicity and carcinogenesis --- p.5<br>Chapter 1.2 --- Hepatocellular carcinoma --- p.12<br>Chapter 1.2.1 --- Epidemiology --- p.12<br>Chapter 1.2.2 --- Aetiological factors --- p.17<br>Chapter 1.2.2.1 --- Hepatitis B virus infection --- p.17<br>Chapter 1.2.2.2 --- Cirrhosis --- p.24<b

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23

MARCHETTI, Luca. "MP Representations of Biological Structures and Dynamics." Doctoral thesis, 2012. http://hdl.handle.net/11562/405336.

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Il tema principale di questa tesi di dottorato riguarda la soluzione di problemi di dinamica inversa nel campo dei P sistemi metabolici (sistemi MP). I sistemi MP, basati sui P sistemi classici di Paun, sono stati introdotti da Manca nel 2004 per permettere la modellazione di sistemi metabolici per mezzo di grammatiche di riscrittura su multi-insiemi. In questo tipo di grammatiche, le trasformazioni di multi-insiemi di oggetti sono regolate, in modo deterministico, da particulari funzioni di stato chiamate regolatori. Il risultato chiave presentato in questa tesi riguarda la definizione di un

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24

Su, Chun-Hui, and 蘇峻輝. "Sludge Metabolism Behaviors of Anaerobic-oxic (A/O) Activated Sludge System under Different P/C Load." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/03681791536739716843.

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碩士<br>國立雲林科技大學<br>防災與環境工程研究所<br>95<br>Abstract Starting-up of newly established Enhanced Biological Phosphorus Removal (EPBR) system requires seeding sludge from other biological treatment plant so as to obtain a PAO-enriched sludge. Some scholars believe PAOs have to coexist with anaerobic bacteria, as PAOs can only take up short chain fatty acid in the anaerobic stage. Some researches mention that micro flora structure of PAO-enriched sludge is very complicated while Betaproteobacteria and Actinobacteria are the main superiority micro flora. However, whether seeding with waste sludge from t

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25

"Effect of Chinese herbal medicine on drug metabolizing enzyme activities: investigation with extract of Ginkgo biloba leaf (EGb 761)." 2003. http://library.cuhk.edu.hk/record=b5891534.

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Sun Huimin.<br>Thesis submitted in: December 2002.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 77-89).<br>Abstracts in English and Chinese.<br>TITLE PAGE --- p.i<br>ACKNOWLEDGEMENTS --- p.ii<br>ABSTRACT --- p.iii<br>ABSTRACT IN CHINESE --- p.v<br>LIST OF PUBLICATIONS --- p.vii<br>ABBREVIATIONS --- p.viii<br>TABLE OF CONTENTS --- p.ix<br>Chapter CHAPTER 1. --- General Introduction --- p.1<br>Chapter 1.1 --- Current Status of Herbal Product Use --- p.1<br>Chapter 1.2 --- Herb-drug interactions --- p.2<br>Chapter 1.2.1. ---

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26

"Induction of estradiol-2-hydroxylase by isoprenyl compounds." 1998. http://library.cuhk.edu.hk/record=b5889730.

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by Wong Che-cheuk, Dobe.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1998.<br>Includes bibliographical references (leaves 98-112).<br>Abstract also in Chinese.<br>Acknowledgements --- p.i<br>Abstracts --- p.ii<br>List of Abbreviation --- p.vi<br>Table of Contents --- p.vii<br>Chapter 1. --- Introduction<br>Chapter 1.1 --- Stages of Cancer Development --- p.1<br>Chapter 1.2 --- Comparison of Breast Cancer in Hong Kong & the United States --- p.2<br>Chapter 1.2.1 --- Statistics of Breast Cancer in the United States --- p.2<br>Chapter 1.2.2 --- Statistics of Breast Cancer in Hong

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27

Seibert, C., B. R. Davidson, B. J. Fuller, Laurence H. Patterson, W. J. Griffiths, and Y. Wang. "Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry." 2009. http://hdl.handle.net/10454/6179.

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Here we report the identification and approximate quantification of cytochrome P450 (CYP) proteins in human liver microsomes as determined by nano-LC-MS/MS with application of the exponentially modified protein abundance index (emPAI) algorithm during database searching. Protocols based on 1D-gel protein separation and 2D-LC peptide separation gave comparable results. In total, 18 CYP isoforms were unambiguously identified based on unique peptide matches. Further, we have determined the absolute quantity of two CYP enzymes (2E1 and 1A2) in human liver microsomes using stable-isotope dilution m

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28

Travica, S., Klaus Pors, Paul M. Loadman, et al. "Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins." 2013. http://hdl.handle.net/10454/6217.

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PURPOSE: Cytochrome P450 2W1 (CYP2W1) is a monooxygenase detected in 30% of colon cancers, whereas its expression in nontransformed adult tissues is absent, rendering it a tumor-specific drug target for development of novel colon cancer chemotherapy. Previously, we have identified duocarmycin synthetic derivatives as CYP2W1 substrates. In this study, we investigated whether two of these compounds, ICT2705 and ICT2706, could be activated by CYP2W1 into potent antitumor agents. EXPERIMENTAL DESIGN: The cytotoxic activity of ICT2705 and ICT2706 in vitro was tested in colon cancer cell lines expre

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