Relevant bibliographies by topics / Metabolic pathways analysis / Dissertations / Theses
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Dissertations / Theses on the topic 'Metabolic pathways analysis'

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Published: 25 May 2024
Last updated: 31 July 2025

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1

Lisowska, Beata. "Genomic analysis and metabolic modelling of Geobacillus thermoglucosidasius NCIMB 11955." Thesis, University of Bath, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.690738.

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Geobacillus thermoglucosidasius is a Gram-positive thermophilic eubacterium (45-70‰) that has the ability to convert pre-treated lignocellulosic material LCM into ethanol. This organism has been genetically engineered such that its yield of ethanol production is in excess of 90% of the theoretical maximum [38]. There remains considerable scope to develop G.thermoglucosidasius to produce alternative fuels and chemicals of industrial importance. For such a useful bacterium the understanding of the global metabolism remains poorly characterised. To gain a better insight into the metabolic pathway
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2

Williams, H. E. "Mathematical modelling of metabolic pathways in pig muscle." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42536/.

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Improving efficiency within the agricultural industry is vital to maintain the food demands of the increasing population, as well the current preference for a more protein rich diet. One avenue for addressing these issues is to study animal-based growth to determine if the efficiency of the production system can be improved by increasing lean muscle mass. The aim of this thesis is to provide an alternative exploration to experimental work to provide an insight into how muscle metabolism in pigs is altered by the administration of a beta-agonist which induces muscle hypertrophy. This will be in
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Sakakibara, Norikazu. "Metabolic analysis of the cinnamate/monolignol and lignan pathways." Kyoto University, 2005. http://hdl.handle.net/2433/145058.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第11658号<br>農博第1514号<br>新制||農||911(附属図書館)<br>学位論文||H17||N4051(農学部図書室)<br>23301<br>UT51-2005-D407<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授 島田 幹夫, 教授 關谷 次郎, 教授 坂田 完三<br>学位規則第4条第1項該当
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4

Jaques, Colin Mark. "Modelling of metabolic pathways for Saccharopolyspora erythraea using flux balance analysis." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446668/.

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The objective of this thesis is to use metabolic modelling techniques to investigate primary and secondary metabolism in S. erythraea and from this to identify key factors controlling flux distribution during secondary metabolism. S. erythraea is a member of the actinomycetes a group of bacteria responsible for the production of a number of commercially important small molecules. Actinomycete physiology is considerably more complicated than that seen in "simple" bacteria such as E. coli. The conjecture investigated in this thesis is that metabolic modelling techniques that take into account th
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Goel, Gautam. "Dynamic flux estimation a novel framework for metabolic pathway analysis /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31769.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Voit, Eberhard O.; Committee Member: Butera, Robert; Committee Member: Chen, Rachel; Committee Member: Kemp, Melissa; Committee Member: Neves, Ana Rute. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Cunha, Oberdam de Lima. "SAMPA (System for Comparative Analysis of Metabolic PAthways) - uma comparação de vias metabólicas." Laboratório Nacional de Computação Científica, 2008. http://www.lncc.br/tdmc/tde_busca/arquivo.php?codArquivo=161.

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Com o advento das tecnologias que propiciaram os seqüenciamentos e as análises de genomas completos em tempo relativamente curto, muitos dados sobre vias metabólicas de procariotos e eucariotos puderam ser gerados. Análises comparativas de vias metabólicas de diferentes genomas podem auxiliar no entendimento das relações organizacionais dentre e fora das espécies. Com base em tais perspectivas, este trabalho tem como finalidade implementar um sistema que permita comparar, através de diferentes critérios, vias metabólicas de bactérias. O sistema SAMPA (System for comparative Analysis of Metabo
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7

Antoniewicz, Maciek Robert. "Comprehensive analysis of metabolic pathways through the combined use of multiple isotopic tracers." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37457.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2006.<br>Includes bibliographical references (p. 287-294).<br>Metabolic Flux Analysis (MFA) has emerged as a tool of great significance for metabolic engineering and the analysis of human metabolic diseases. An important limitation of MFA, as carried out via stable isotope labeling and GC/MS measurements, is the large number of isotopomer equations that need to be solved. This restriction reduces the ability of MFA to fully utilize the power of multiple isotopic tracers in elucidating the physiology of compl
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8

Beltrame, L. "Indentification of disregulated metabolic pathways by transcriptomic analysis in renal cell carcinoma samples." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/44738.

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Microarray analysis, with its ability of simultaneously assessing the expression of thousands of genes, has always attracted interest in cancer research. However, traditional microarray studies suffer from many shortcomings, which result often in poor reproducibility of the studies. Recently, a new approach called group testing, targeting deregulated groups of genes (such as pathways) rather than single entities, has been proposed. This work focuses on the use of group testing techniques towards the identification of deregulated pathways in renal cell carcinoma over three publicly available mi
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9

Henderson, David Allen. "Reconstruction of metabolic pathways by the exploration of gene expression data with factor analysis." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/30089.

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Microarray gene expression data for thousands of genes in many organisms is quickly becoming available. The information this data can provide the experimental biologist is powerful. This data may provide information clarifying the regulatory linkages between genes within a single metabolic pathway, or alternative pathway routes under different environmental conditions, or provide information leading to the identification of genes for selection in animal and plant genetic improvement programs or targets for drug therapy. Many analysis methods to unlock this information have been both propose
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10

Zychlinski-Kleffmann, Anne Kathrin von. "Rice etioplast proteome analysis: Novel insights into the complexity of metabolic and regulatory pathways /." Zürich : ETH, 2005. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16120.

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11

Sander, Guy William. "Quantitative analysis of metabolic pathways in Catharanthus roseus hairy roots metabolically engineered for terpenoid indole alkaloid overproduction." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3369886.

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12

Mahout, Maxime. "Logic programming tools for metabolic fluxes analysis and biological applications." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASG086.

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En biologie des systèmes, l'analyse des voies métaboliques est une méthode essentielle pour étudier le métabolisme et améliorer la compréhension du fonctionnement des systèmes vivants. Deux concepts clés sont l'analyse des modes élémentaires de flux (EFMs), qui permet de décrire les réseaux métaboliques en termes de voies minimales, et les Minimal Cut Sets (MCSs), représentant les coupures minimales de flux du réseau en termes de réactions. Dans le cadre de cette thèse, nous avons développé une méthode de programmation logique pour le calcul des modes élémentaires de flux: aspefm. L'outil est
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Tuttle, Matthew Alan. "In silico analysis of zebrafish leptin-a knockdown gene expression data reveals enrichment for metabolic and developmental pathways including morpholino artifacts." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1492641073183086.

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14

Sehr, Christiana Verena [Verfasser], Andreas [Akademischer Betreuer] [Gutachter] Kremling, Alberto [Gutachter] Marín-Sanguino, and Eberhard [Gutachter] Voit. "Model based analysis of central metabolic pathways of Halomonas elongata / Christiana Verena Sehr ; Gutachter: Andreas Kremling, Alberto Marin-Sanguino, Eberhard Voit ; Betreuer: Andreas Kremling." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1120013828/34.

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Schulz, Maike [Verfasser], Enno [Akademischer Betreuer] Klußmann, Jens [Gutachter] Kurreck, Roland [Gutachter] Lauster, and Enno [Gutachter] Klußmann. "Analysis of metabolic pathways controlling cAMP-regulated aquaporin-2 trafficking in renal principal cells / Maike Schulz ; Gutachter: Jens Kurreck, Roland Lauster, Enno Klußmann ; Betreuer: Enno Klußmann." Berlin : Technische Universität Berlin, 2018. http://d-nb.info/1168324017/34.

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16

Shehabi, Haleem Ziad. "In-vitro Evidence for Novel, Non-Classical, Alternative P450scc-Initiated Vitamin D Metabolic Pathways in Human Placenta via HPLC-UV/DAD and LC-ESI-MS/MS Analysis." Thesis, Curtin University, 2020. http://hdl.handle.net/20.500.11937/89121.

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Current findings identify and substantiate existence of previously unrecognised, likely, in-vivo alternative, non-classical P450scc-initiated vitamin D3/D2 metabolic pathways within in-vitro human placenta models. These pathways are further modified by CYP27A1 or CYP27B1 activity in human placenta and confirmed where required by purified human enzyme studies. This data was closely verified using equivalent in-vitro bovine adrenal cortex models and where necessary by purified bovine enzyme studies. Profiling was achieved by newly developed HPLC-UV/DAD and LC-ESI-MS/MS methodology.
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17

Planes, Francisco J. "Metabolic pathway analysis via integer linear programming." Thesis, Brunel University, 2008. http://bura.brunel.ac.uk/handle/2438/6134.

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The understanding of cellular metabolism has been an intriguing challenge in classical cellular biology for decades. Essentially, cellular metabolism can be viewed as a complex system of enzyme-catalysed biochemical reactions that produces the energy and material necessary for the maintenance of life. In modern biochemistry, it is well-known that these reactions group into metabolic pathways so as to accomplish a particular function in the cell. The identification of these metabolic pathways is a key step to fully understanding the metabolic capabilities of a given organism. Typically, metabol
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18

Zhang, Rui. "Metabolic Disorder leads to Retinal degeneration: Function, morphology and metabolic pathway analysis." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25459.

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INTRODUCTION The retina prefers to metabolize glucose through glycolysis rather than oxidative phosphorylation (OXPHOS) to meet their energy demand even when oxygen is abundant, known as the “Warburg effect”, despite having abundant functional mitochondria. We created transgenic mice with selective knockdowns of key enzymes in glycolysis and OXPHOS including hexokinase (HK) 2, lactate dehydrogenase (LDH) A and pyruvate dehydrogenase (PDH) E1α in rods to study the importance of glycolysis and OXPHOS in retinal metabolism and the role of metabolic derangement in the pathogenesis of retinal dise
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Ullah, Ehsan. "Pathway Analysis of Metabolic Networks using Graph Theoretical Approaches." Thesis, Tufts University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3640954.

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<p> Cellular pathways defining biochemical transformational routes are often utilized as engineering targets to achieve industrial-scale production of commercially useful biomolecules including polyesters, building blocks for polymers, biofuels, and therapeutics derived from isoprenoids, polyketides, and non-ribosomal peptides. Identifying target pathways can be expedited using computational tools, leading to reduced development cost, time, and effort, and enabling new discoveries with potential positive impact on human health and the environment. </p><p> This thesis addresses three cellula
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Goel, Gautam. "Biochemical Systems Toolbox." Thesis, Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14509.

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The field of biochemical systems modeling and analysis is faced with an unprecedented flood of data from experimental methodologies of molecular biology. While these techniques continue to leapfrog ahead in the speed, volume and finesse with which they generate data, the methods of data analysis and interpretation, however, are still playing the catch-up game. The notions of systems analysis have found a new foothold, under the banner of Systems Biology, with the promise of uncovering the rationale for the designs of biological systems from their parts lists, as they are generated by experime
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Schilling, Christophe Heinz. "On systems biology and the pathway analysis of metabolic networks /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9981956.

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22

Liu, Ensheng Yuan Jian-Min. "Sensitivity, non-equilibrium thermodynamic and control analyses of insulin metabolic signaling pathways /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1862.

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Magnus, Jørgen Barsett. "Metabolic egineering of the valine pathway in corynebacterium glutamicum analysis and modelling /." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-34007.

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Perera, Munasinhage Venura Lakshitha. "Metabolic profiling of plant disease : from data alignment to pathway predictions." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3906.

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Understanding the complex metabolic networks present in organisms, through the use of high throughput liquid chromatography coupled mass spectrometry, will give insight into the physiological changes responding to stress. However the lack of a proper work flow and robust methodology hinders verifiable biological interpretation of mass profiling data. In this study a novel workflow has been developed. A novel Kernel based feature alignment algorithm, which outperformed Agilent’s Mass profiler and showed roughly a 20% increase in alignment accuracy, is presented for the alignment of mass profili
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Strickland, Natalie Judith. "In silico and functional analyses of the iron metabolism pathway." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79871.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Iron is an essential micronutrient that is an absolute requirement for correct cellular function in all eukaryotic organisms. However, ferrous iron has the ability to catalyze the formation of potentially toxic reactive oxygen species and regulation of iron metabolism is therefore of critical importance. Currently, there is little known about the co-ordinated regulation of the plethora of genes coding for proteins involved in this biochemical pathway, with the exception of the well characterized post-transcriptional IRE/IRP
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CHUNG, Sook Hyun. "Genomic analysis of a transgenic model of selective Müller cell ablation: morphology, microarray and metabolic pathway analysis." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9985.

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Müller cell dysfunction has been found in many retinal diseases such as diabetic retinopathy and macular telengiectasia. To investigate their potential role in the pathogenesis of retinal diseases, we have created a novel transgenic mouse model of conditional Müller cells ablation. The aim of this study was to perform genomic analysis with the whole retinal samples, then to examine metabolic dysfunction in patches of Müller cell loss that were isolated by laser capture microdissection (LCM). Microarray analysis with whole retinal samples revealed increased transcription of genes responsible fo
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D'Souza, Arun. "PathCaseMAW: A Workbench for Metabolomic Analysis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452.

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Magnus, Jørgen Barsett [Verfasser]. "Metabolic egineering of the valine pathway in Corynebacterium glutamicum : analysis and modelling / Jørgen Barsett Magnus." Jülich : Forschungszentrum, Zentralbibliothek, 2007. http://d-nb.info/997058552/34.

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Kitami, Toshimori. "GENETIC, EVOLUTIONARY, AND GENOMIC ANALYSIS OF HOMOCYSTEINE AND FOLATE PATHWAY REGULATION." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1127865525.

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Singh, Sumit Kumar. "Pathway Pioneer: A Web-Based Graphical Tool for the Organization and Flux Analysis of Metabolic Networks." DigitalCommons@USU, 2014. https://digitalcommons.usu.edu/etd/2796.

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As stoichiometric metabolic models increase in complexity and delity, design and reconstruction tools are urgently needed to increase the productivity of this time-consuming process. Engineers require software for the exploration, evaluation, and rapid analysis of model alternatives within an intuitive visualization and data management framework. This thesis introduces such a tool: Pathway Pioneer (www.pathwaypioneer.org), a web based system built as a front-end graphical user interface to the ux balance analysis tool COBRA. Pathway Pioneer adds additional functionality for customized network
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Dupont, Pierre-Yves. "Conception d'outils bioinformatiques pour la modélisation de voies métaboliques et de leur régulation." Thesis, Clermont-Ferrand 1, 2011. http://www.theses.fr/2011CLF1MM27/document.

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La biologie des systèmes actuelle s’appuie sur des techniques d’analyse biologique à haut débit comme la transcriptomique ou la métabolomique. Cependant, ces techniques haut débit ont leurs limites et peuvent générer des erreurs. En croisant les résultats de différentes techniques d’analyse biologique, nous espérons pallier une partie de leurs limites. À cet effet, nous avons commencé à développer une plateforme de modélisation, MPSA (Metabolic Pathways Software Analyzer), permettant d’intégrer les données générées à des réseaux métaboliques. MPSA permet de représenter les graphes de voies mét
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Wilson, Emma. "Analysis of phosphatidylinositol metabolism and ER-mitochondria contact sites in the PINK1/Parkin pathway." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19741/.

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33

Guo, Weihua. "Computational Modeling of Planktonic and Biofilm Metabolism." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/79669.

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Most of microorganisms are ubiquitously able to live in both planktonic and biofilm states, which can be applied to dissolve the energy and environmental issues (e.g., producing biofuels and purifying waste water), but can also lead to serious public health problems. To better harness microorganisms, plenty of studies have been implemented to investigate the metabolism of planktonic and/or biofilm cells via multi-omics approaches (e.g., transcriptomics and proteomics analysis). However, these approaches are limited to provide the direct description of intracellular metabolism (e.g., metabolic
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Goerner-Potvin, Patricia. "Transcriptomic analysis of Sinorhizobium meliloti 1021 focusing on tricarboxylic acid cycle, nitrogen fixation, and carbon metabolism pathways." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123171.

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Sinorhizobium meliloti 1021 is a nitrogen-fixing symbiont of legume plants Medicago, Melilotus and Trigonella. This bacterium is a model organism for tricarboxylic acid (TCA) cycle, and other genetic studies. The complete S. meliloti 1021 bacteroid transcriptome was sequenced and was compared to the complete sequenced transcriptome of free-living cells grown on malate a as sole carbon source. Twenty-seven genes were downregulated more than 20 folds when compared to the control treatment malate. Most of these downregulated genes were of unknown function or part of the carbohydrate transport and
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Zheng, Lianqing. "Statistical identification of metabolic reactions catalyzed by gene products of unknown function." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/15594.

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Doctor of Philosophy<br>Department of Statistics<br>Gary L. Gadbury<br>High-throughput metabolite analysis is an approach used by biologists seeking to identify the functions of genes. A mutation in a gene encoding an enzyme is expected to alter the level of the metabolites which serve as the enzyme’s reactant(s) (also known as substrate) and product(s). To find the function of a mutated gene, metabolite data from a wild-type organism and a mutant are compared and candidate reactants and products are identified. The screening principle is that the concentration of reactants will be higher and
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Maleki-Yazdi, Keon. "The genetic determinants of small-for-gestational-age infants in thrombophilia and folate metabolism pathways investigated through meta-analysis." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121509.

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Background: Previous data have demonstrated associations for an increased risk of the small-for-gestational-age (SGA) outcome in offspring of pregnant women with thrombophilia and folate metabolism gene polymorphisms. However, these results have not been consistent.Methods: The objective of this thesis is to review genetic association studies in thrombophilia and folate metabolism pathways for the SGA outcome (defined as birth weight below the 10th percentile for gestational age and sex according to national standards). We performed a series of meta-analyses for commonly studied maternal and n
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Figueiredo, Luís Filipe Domingos Pereira de [Verfasser], Stefan Akademischer Betreuer] Schuster, Peter [Akademischer Betreuer] [Dittrich, and Marie-France [Akademischer Betreuer] Sagot. "Metabolic Pathway Analysis : from small to genome-scale networks / Luis F. D. P. de Figueiredo. Gutachter: Stefan Schuster ; Peter Dittrich ; Marie-France Sagot." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2011. http://d-nb.info/1016368283/34.

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Momin, Amin Altaf. "Application of bioinformatics in studies of sphingolipid biosynthesis." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34842.

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The studies in this dissertation demonstrate that the gene expression pathway maps are useful tools to notice alteration in different branches of sphingolipid biosynthesis pathway based on microarray and other transcriptomic analysis. To facilitate the integrative analysis of gene expression and sphingolipid amounts, updated pathway maps were prepared using an open access visualization tool, Pathvisio v1.1. The datasets were formatted using Perl scripts and visualized with the aid of color coded pathway diagrams. Comparative analysis of transcriptomics and sphingolipid alterations from experim
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Halama, Anna Maria [Verfasser], Jerzy [Akademischer Betreuer] Adamski, Karsten [Akademischer Betreuer] Suhre, and Johann Josef [Akademischer Betreuer] Hauner. "Analyses of metabolic pathways of cellular processes in apoptosis and adipogenesis / Anna Maria Halama. Gutachter: Karsten Suhre ; Jerzy Adamski ; Johann Josef Hauner. Betreuer: Jerzy Adamski." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1063090520/34.

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Celton, Magalie. "Etude de la réponse de Saccharomyces cerevisiae à une perturbation NADPH par une approche de biologie des systèmes." Thesis, Montpellier, SupAgro, 2011. http://www.theses.fr/2011NSAM0023/document.

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L'élucidation des propriétés du réseau métabolique est fondamentale pour la compréhension du fonctionnement cellulaire et pour l'élaboration de stratégies d'ingénierie métabolique. L'objectif de cette thèse était de mieux comprendre la régulation du métabolisme du NADPH, un métabolite "hub" qui joue un rôle central dans de nombreux processus cellulaires, chez Saccharomyces cerevisiae en fermentation. Nous avons utilisé une démarche systématique couplant modélisation et approches multi-“omics” pour étudier de façon quantitative la réponse à une perturbation de la demande en NADPH. Un système ex
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Cubuk, Cankut. "Modeling Functional Modules Using Statistical and Machine Learning Methods." Doctoral thesis, Universitat Politècnica de València, 2020. http://hdl.handle.net/10251/156175.

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[ES] La comprensión de los aspectos de la funcionalidad de las células que cuentan para los mecanismos de las enfermedades es el mayor reto de la medicina personalizada. A pesar de la disponibilidad creciente de los datos de genómica y transcriptómica, sigue existiendo una notable brecha entre la detección de las perturbaciones en la expresión de genes y la comprensión de su contribución en los mecanismos moleculares que últimamente tienen relación importante con el fenotipo estudiado. A lo largo de la última década, distintos modelos computacionales y matemáticos se han propuesto para el anál
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Abily-Donval, Lénaïg. "Exploration des mécanismes physiopathologiques des mucopolysacharidoses et de la maladie de Fabry par approches "omiques" et modulation de l'autophagie. Urinary metabolic phenotyping of mucopolysaccharidosis type I combining untargeted and targeted strategies with data modeling Unveiling metabolic remodeling in mucopolysaccharidosis type III through integrative metabolomics and pathway analysis." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR108.

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Les pathologies lysosomales sont des maladies liées au déficit quantitatif ou qualitatif d’une hydrolase ou d’un transporteur à l’origine d’une atteinte multiviscérale potentiellement sévère. Certaines de ces pathologies sont accessibles à des traitements mais ces thérapeutiques sont uniquement symptomatiques et ne guérissent pas les patients. Même si le phénomène de surcharge peut expliquer entre autres la symptomatologie observée, la physiopathologie de ces maladies est complexe et non précisément connue. Une meilleure connaissance de ces pathologies pourrait permettre d’améliorer leur prise
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Ronconi, Silvia [Verfasser], Ulrich [Akademischer Betreuer] Genschel, and Alfons [Akademischer Betreuer] Gierl. "The Pantothenic Acid and Coenzyme A Pathway in Plants and Archaea : Analysis of Metabolite Levels in Arabidopsis thaliana and Characterization of Archaeal Enzymes for the Synthesis of 4'-phosphopantetheine / Silvia Ronconi. Gutachter: Alfons Gierl. Betreuer: Ulrich Genschel." München : Universitätsbibliothek der TU München, 2006. http://d-nb.info/1058141473/34.

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Darney, Keyvin. "Towards next generation risk assessment of chemicals : bayesian meta-analysis of human variability in metabolism and transporters and application for the derivation of pathway-related uncertainty factors Aggregate exposure of the adult French population to pyrethroids, in Toxicology and Applied Pharmacology 351, July 2018 Inter-ethnic differences in CYP3A4 metabolism: A Bayesian meta-analysis for the refinement of uncertainty factors in chemical risk assessment, in Computational Toxicology 12, November 2019 Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment, in Environment International 138, May 2020 Human variability in influx and efflux transporters in relation to uncertainty factors for chemical risk assessment, in Food and Chemical Toxicology 140, June 2020." Thesis, Brest, 2020. http://www.theses.fr/2020BRES0013.

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Dans le monde moderne, les humains sont exposés à une vaste gamme de produits chimiques tout au long de leur vie. L'évaluation des risques des substances chimiques pour l'homme revêt une importance capitale pour la santé publique et permet de calculer des niveaux sûrs d'exposition aiguë et chronique pour des sous-groupes de la population humaine, notamment les nouveau-nés, les enfants, les personnes âgées et les populations d’origine géographique et de polymorphismes génétiques différents. L'application des données cinétiques liées aux voies métaboliques pour tenir compte de la variabilité hum
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"Computational discovery and analysis of metabolic pathways." Thesis, 2010. http://hdl.handle.net/1911/61991.

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Finding novel or non-standard metabolic pathways, possibly spanning multiple species, has important applications in fields such as metabolic engineering, metabolic network analysis, and metabolic network reconstruction. Traditionally, this has been a manual process, but the large volume of metabolic data now available has created a need for computational tools to automatically identify biologically relevant pathways. This thesis presents new algorithms for automatically finding biologically meaningful linear and branched metabolic pathways in multi-genome scale metabolic networks. These algori
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CHAN, LUNG-YI, and 湛隆誼. "Metabolic Flux Analysis for Metabolic Pathways of Acetate and Propionate in UASB Anaerobic Tank." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/06223038823611352887.

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碩士<br>國立臺中教育大學<br>科學教育與應用學系環境教育及管理碩士班<br>104<br>In this study, the metabolic flux analysis (MFA) was employed to explore the metabolic pathway and metabolic flux in the Up-flow Anaerobic Sludge Blanket (UASB) asnaerobic tank. It was found that when the extra addition of acetic acid, acetic acid concentration changes from the starting 9769.04 mg/L, eventually becomes 6930.67 mg/L, acetic acid utilization was 29%; when adding additional acid, a propionic acid concentration changes by the start 6580.98 mg/L, eventually becomes 4704.79 mg/L, acid utilization rate of 28.5%. Metabolism acetic path t
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Morgan, John Allen. "Analysis of metabolic flux of secondary metabolite pathways in Catharanthus roseus hairy root cultures." Thesis, 1999. http://hdl.handle.net/1911/19420.

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Catharanthus roseus, a tropical plant, produces the valuable anti-cancer compounds, vincristine and vinblastine in extremely low amounts. My research objectives were to examine the response of plant secondary metabolism to various metabolic perturbations, and indicate limitations in the reaction network. In hairy roots, tabersonine is an important intermediate in the synthesis of vindoline, a monomer in the formation of the anti-cancer compounds that are generally absent from cell and hairy root cultures. To understand how much metabolic flux is directed toward the tabersonine branchpoint, tra
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"Analysis and engineering of metabolic pathways of Lactobacillus panis PM1." Thesis, 2014. http://hdl.handle.net/10388/ETD-2014-04-1504.

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Lactobacillus panis PM1 is a novel microorganism isolated from thin stillage (TS), a major by-product resulting from bioethanol fermentation, and was selected as the focus of this thesis due to its ability to produce 1,3-propanediol (1,3-PDO) from glycerol. The purpose of this thesis was to understand the central and auxiliary metabolic pathways of L. panis PM1 and to metabolically-engineer strain PM1 based on the improved metabolic knowledge for industrial applications. The 16S rRNA sequence and carbohydrate fermentation pattern were used to classify L. panis PM1 as belonging to the group III
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CHIA-FU, LIN, and 林嘉福. "Metabolic Flux Analysis for Metabolic Pathways of Butyric in UASB Anaerobic sludge and its Power generation Performance." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/cc9qj4.

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碩士<br>國立臺中教育大學<br>科學教育與應用學系環境教育及管理碩士班<br>105<br>With instant development of industry and technology, people's life is convenient, but numerous environmental pollutions have a severe effect on the earth's environment, including industrial waste, water pollution, air pollution, soil pollution and noise pollution. At present, all kinds of environmental problems are paid increasing attention to. This study uses the anaerobic sludge reclaimed by Up-flow Anaerobic Sludge Blanket (UASB) for experiment, which is mixed with 4 g/L butyric acid to discuss the metabolic pathway and generating efficiency o
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Temate, Tiagueu Yvette Charly B., and Tiagueu Yvette C. B. Temate. "Methods for Differential Analysis of Gene Expression and Metabolic Pathway Activity." 2016. http://scholarworks.gsu.edu/cs_diss/102.

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RNA-Seq is an increasingly popular approach to transcriptome profiling that uses the capabilities of next generation sequencing technologies and provides better measurement of levels of transcripts and their isoforms. In this thesis, we apply RNA-Seq protocol and transcriptome quantification to estimate gene expression and pathway activity levels. We present a novel method, called IsoDE, for differential gene expression analysis based on bootstrapping. In the first version of IsoDE, we compared the tool against four existing methods: Fisher's exact test, GFOLD, edgeR and Cuffdiff on RNA-Seq da
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