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1

Nutrition and metabolism in pregnancy: Mother and fetus. Oxford University Press, 1990.

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2

Sutherland, H. W., J. M. Stowers, and D. W. M. Pearson, eds. Carbohydrate Metabolism in Pregnancy and the Newborn · IV. Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1680-6.

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3

C, Tsang Reginald, ed. Calcium and magnesium metabolism in early life. CRC Press, 1995.

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4

Schürch, Beat. Maternal energy metabolism in humans: An annotated bibliography. Nestlé Foundation, 1986.

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5

1946-, Allen Lindsay, King Janet 1941-, and Lönnerdal Bo 1938-, eds. Nutrient regulation during pregnancy, lactation, and infant growth. Plenum Press, 1994.

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6

M, Cowett Richard, ed. Principles of perinatal-neonatal metabolism. 2nd ed. Springer, 1998.

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7

Nutrient, Regulation during Pregnancy Lactation and Infant Growth (1992 Stockholm Sweden and Helsinki Finland). Nutrient regulation during pregnancy, lactation, and infant growth. Plenum, 1994.

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8

1922-, Schwartz Robert, ed. Disorders of carbohydrate metabolism in infancy. 3rd ed. Blackwell Scientific Publications, 1991.

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9

Siva Subramanian, K. N. 1945- and Wastney Meryl E, eds. Kinetic models of trace element and mineral metabolism during development. CRC Press, 1995.

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10

N, Taylor Sarah, and Hollis Bruce W, eds. New insights into vitamin D during pregnancy, lactation, & early infancy. Hale Pub., 2010.

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11

Folic acid and the prevention of disease: Report of the Committee on Medical Aspects of Food and Nutrition Policy. Stationery Office, 2000.

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12

Ferrazzi, Enrico, and Barry Sears, eds. Metabolic Syndrome and Complications of Pregnancy. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16853-1.

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13

Elliott, Katherine, and Maeve O'Connor. Pregnancy Metabolism, Diabetes and the Fetus. Wiley & Sons, Incorporated, John, 2009.

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14

Production, Concentration and Metabolism During Pregnancy. Elsevier, 1985. http://dx.doi.org/10.1016/c2009-0-00734-x.

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15

Elliott, K., and CIBA Foundation Symposium Staff. Pregnancy Metabolism, Diabetes and the Fetus. Wiley & Sons, Limited, John, 2008.

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16

Carbohydrate Metabolism in Pregnancy and the Newborn 1978. Springer, 2011.

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17

Sutherland, Hamish W. Carbohydrate Metabolism in Pregnancy and the Newborn · Iv. Springer, 2012.

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18

Sutherland, Hamish W., John M. Stowers, and Donald W. M. Pearson. Carbohydrate Metabolism in Pregnancy and the Newborn · IV. Springer, 2012.

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19

Franks. Endocrinology of Pregnancy (Bailliere's Clinical Endocrinology and Metabolism). Elsevier, 1990.

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20

W, Sutherland Hamish, Stowers John M, Pearson, D. W. M. 1950-, and International Colloquium on Carbohydrate Metabolism in Pregnancy and the Newborn (4th : 1988 : University of Aberdeen), eds. Carbohydrate metabolism in pregnancy and the newborn IV. Springer-Verlag, 1989.

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21

W, Sutherland Hamish, Stowers John M, and Pearson, D. W. M. 1950-, eds. Carbohydrate metabolism in pregnancy and the newborn 4. Springer-Verlag, 1989.

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22

Sutherland, H. W., and J. M. Stowers. Carbohydrate Metabolism in Pregnancy and the Newborn 1978. Springer London, Limited, 2012.

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23

Cowett, Richard M. Principles of Perinatal-Neonatal Metabolism. Springer, 2012.

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24

Raiten, Daniel J. Vitamin B-6 Metabolism in Pregnancy, Lactation, and Infancy. Taylor & Francis Group, 2021.

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25

J, Raiten Daniel, ed. Vitmanin B-6 metabolism in pregnancy, lactation, and infancy. CRC Press, 1995.

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26

Raiten, Daniel J. Vitamin B-6 Metabolism in Pregnancy, Lactation, and Infancy. Taylor & Francis Group, 2021.

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27

Raiten, Daniel J. Vitamin B-6 Metabolism in Pregnancy, Lactation, and Infancy. Taylor & Francis Group, 2021.

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28

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Magnesium in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0021.

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Magnesium in important for a wide variety of physiological processes; prominent among them is the control of muscle contractions, cardiac function, and carbohydrate metabolism. In pregnancy, low magnesium status is associated with hypertension, pre-eclampsia, gestational diabetes, leg cramping, and preterm labour. Magnesium has been used extensively in obstetrics to reduce uterine contractility in threatened preterm labour. Although current evidence does not support a requirement for magnesium supplementation for most pregnant women, those who are overweight, have risk factors for hypertensive or metabolic disorders or malabsorption syndromes, or who are carrying multiple fetuses, should pay particular attention to their diets and should be monitored for signs of magnesium deficiency. Consuming a magnesium-rich diet throughout pregnancy is recommended.
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29

Ahmed, Ahmed I., Sarah Aldhaheri, and Allison Bannick. Inherited Metabolic Diseases (IMDs) and Pregnancy. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190667351.003.0030.

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Inherited metabolic diseases (IMDs) are rare genetic disorders: clinically heterogeneous, and they can present at any age. With the expanded newborn screening panels, many of the IMDs have been successfully screened. Early diagnosis and treatment of these conditions have led to improved neurological outcomes and overall survival of these individuals, and now many of them are reaching childbearing age. Despite treatment, the potential presence of preexisting organ involvement may not only impact their fertility potentials but also may impose a higher risk of adverse maternal and fetal outcomes. Pregnancy leads to an extra strain on maternal metabolism; this may result in the manifestation of symptoms of a previously unknown disease or a progression of a known disease. This chapter will address the possible complications of some inherited disorders of metabolism that are associated with maternal or fetal neurological manifestations such as disorders of energy metabolism (eg, mitochondrial disorders, adult onset urea cycle disorders, ornithine transcarbamylase (OTC) deficiency, amino acidopathies, phenylketonuria (PKU), and impaired fatty acid oxidation disorders). We will provide special emphasis on the available potential treatments and plan of care during pregnancy and postpartum periods.
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30

M, Cowett Richard, ed. Principles of perinatal-neonatal metabolism. Springer-Verlag, 1991.

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31

Cowett, Richard M. Principles of Perinatal-Neonatal Metabolism. Springer London, Limited, 2012.

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32

Cowett, Richard M. Principles of Perinatal-Neonatal Metabolism. Springer London, Limited, 2012.

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33

Mandel, Susan J. Pregnancy and Endocrinology Disorders, An Issue of Endocrinology and Metabolism Clinics. Saunders, 2006.

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34

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin B1 (thiamine) in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0007.

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Vitamin B1 (thiamine) is involved in nervous system and muscle function and is essential for carbohydrate metabolism. Deficiency is common in Asia, where diets are often high in thiamine-depleted polished rice and can be low in other food sources. Pregnancy imposes an increasing requirement for thiamine over the course of gestation, and deficiency can lead to widespread metabolic disturbances affecting the placenta and fetus. Nutritional deficiency for thiamine is rare in people who consume a moderately varied diet that contains whole grains. However, excessive vomiting in pregnancy can cause thiamine depletion, in which case antenatal vitamins containing thiamine and other B vitamins may be beneficial.
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35

Hau, Jann. Pregnancy Proteins in Animals: Proceedings of the International Meeting, Copenhagen, Denmark, April 22-24, 1985. De Gruyter, Inc., 1986.

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36

Hau, Jann. Pregnancy Proteins in Animals: Proceedings of the International Meeting Copenhagen, Denmark, April 22-24 1985. De Gruyter, Inc., 2019.

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37

Pregnancy proteins in animals: Proceedings of the International Meeting, Copenhagen, Denmark, April 22-24, 1985. W. de Gruyter, 1986.

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38

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Selenium in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0023.

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The essential trace mineral selenium is a component of antioxidant enzymes and proteins that regulate thyroid hormone metabolism and immune function. Thyroid metabolism is sensitive to selenium in the diet, and selenium deficiency can exacerbate the effects of iodine deficiency. Selenium deficiency is also associated with enhanced viral virulence and is a risk factor for perinatal transmission of HIV. Several selenium-dependent proteins are important in male fertility. Most pregnant women in developed countries will be able to meet selenium requirements through their usual diet, but because some foods differ widely in selenium content according to their geographical sources, a variety of foods should be eaten to ensure adequate intake and to avoid toxicity. Taking selenium supplements in addition to adequate dietary intake is not recommended, as the safe intake range is narrow.
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39

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Choline in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0014.

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Choline is required for the structural integrity of cell membranes and is involved in methyl-group metabolism, neurotransmission, transmembrane signalling, and lipid and cholesterol transport and metabolism. Choline is critical during fetal and neonatal life to ensure optimal brain and cognitive development. There is an intersection of the pathways of choline, folate, and vitamin B12 in the formation of methionine from homocysteine. Maternal peri-conceptional deficiency for choline, like folate, is associated with an increased risk of neural tube defects in the offspring. It is recommended that pregnant women do not restrict fat severely from their diets, as choline is derived from the lipid content of food. Strict vegetarian or vegan diets may be low in choline. The high secretion rate of choline into breast milk means that lactating women have a high demand, and multivitamins containing choline may be helpful for both pregnancy and breastfeeding.
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40

Miller, Richard K. Trophoblast Research Vol. 1: Fetal Nutrition Metabolism and Immunology. Springer, 2012.

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41

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin B9 (folate) in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0012.

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Folate is a coenzyme in multiple biochemical pathways involving one-carbon metabolism, including amino acid metabolism, DNA and RNA synthesis, homocysteine metabolism, and methylation of DNA. The most overt consequence of folate deficiency is megaloblastic anaemia caused by the inhibition of DNA synthesis in red blood cell production. Folate deficiency may also influence the ability to maintain DNA methylation patterns in replicating cells, resulting in lasting phenotypic changes. Embryogenesis and fetal growth require higher levels of folate, which must be supplied maternally during pregnancy. A link between low maternal folate levels and the occurrence of neural tube defects has long been recognized. Other effects in pregnancy include increased risks of pre-eclampsia and placental vascular disorders. The general recommendation is for supplementation prior to conception and throughout pregnancy with 400 #amp;#x03BC;g of folic acid in tablet form, in addition to dietary sources, which can reduce the risk of neural tube defects.
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42

1947-, Strauss Jerome F., and Lyttle C. Richard, eds. Uterine and embryonic factors in early pregnancy. Plenum Press, 1991.

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43

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin B7 (biotin) in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0011.

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Biotin is a water-soluble B vitamin (vitamin B7) which acts as a coenzyme to carboxylases and has roles in gluconeogenesis, fatty acid synthesis, and amino acid catabolism. Reduced activity of biotin-dependent enzymes (acetyl-CoA carboxylase I and II, and propionyl-CoA carboxylase) alters lipid metabolism and may impair synthesis of polyunsaturated fatty acids and prostaglandins; in addition, biotin has effects on gene expression by binding covalently to histones. Deficiency can be caused by prolonged consumption of egg whites, which contain the biotin-binding protein avidin. Smoking accelerates the degradation of biotin, which can result in marginal biotin deficiency. The effects of deficiency include disruption of immune function and lipid metabolism, with some evidence of teratogenicity in animals. Dietary deficiency is unlikely, although high consumption of egg whites should be avoided in pregnancy.
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44

Molitch, Mark E. Pregnancy and Endocrine Disorders, an Issue of Endocrinology and Metabolism Clinics of North America. Elsevier - Health Sciences Division, 2019.

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45

Kincl, F. A., and J. R. Pasqualini. Hormones and the Fetus Vol. 1 : Volume 1: Production, Concentration and Metabolism During Pregnancy. Elsevier Science & Technology Books, 2013.

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46

Blanchette, Phillip Stanley. Hair analysis for the evaluation of maternal tobacco exposure and nicotine metabolism during pregnancy. 2004.

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47

Blanchette, Phillip Stanley. Hair analysis for the evaluation of maternal tobacco exposure and nicotine metabolism during pregnancy. 2005.

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48

MD, Rachel Pessah Pollack, and Lois Jovanovič MD. Endocrine Disorders During Pregnancy, An Issue of Endocrinology and Metabolism Clinics of North America. Saunders, 2012.

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49

Knopp, Robert H., and Herrera Emilio. Perinatal Biochemistry. Taylor & Francis Group, 2020.

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50

Knopp, Robert H., and Herrera Emilio. Perinatal Biochemistry. Taylor & Francis Group, 2020.

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