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Dissertations / Theses on the topic 'Metabolite production in fungi'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Sutkowski, A. C. "The synthesis and biosynthesis of natural products." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380830.

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2

Schierbaum, Anna. "Occurrence, distribution and agroactive metabolite production of endophytic fungi isolated from marine and shoreline plants." Thesis, University of Portsmouth, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479128.

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3

West, Lauren Kelly. "An Approach to Enhance Secondary Metabolite Production of Endosymbiotic Fungi Through the Incorporation of Resin into Culture Media." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/145097.

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4

Bandani, Ali Reza. "Production and function of metabolites by the entomopathogenous fungi, Tolypocladium spp." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270304.

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5

Cheeseman, Kevin. "Aspects of Penicillium genomics : Molecular combing genome assembly, genetic exchange in food and potential for secondary metabolite production." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112280/document.

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Les Penicilliums sont des champignons filamenteux appartenant au genre Ascomycota. Ces champignons ont été utilisés par l’homme pour la production de nourriture depuis des siècles. Plus récemment, ils ont aussi été utilisés dans l’industrie biotechnologique pour la production de composés chimiques d’intérêts pharmaceutiques. Certaines espèces de Penicillium sont par ailleurs des moisissures contaminants certains aliments, d’autres sont des pathogènes de plantes, y compris de certains fruits. Leur génomique est globalement peut connue. Dans cette étude, nous avons analysé les génomes de deux es

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6

Clipston, Julie. "An investigation into the production by marine-derived fungi of secondary metabolites with pesticidal activities." Thesis, University of Portsmouth, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343340.

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7

Rydevik, Axel. "Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220906.

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This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g., it is easily up-scaled and ethical problems associated with animal-based models are avoided. The metabolism of bupivacaine and the selective androgen receptor modulators (SARMs) S1, S4 and S24 by the fungi Cunninghamella elegans and Cunninghamella blakesleeana was investigated. The detected m

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8

Kikukawa, Hiroshi. "Metabolic analysis and development of efficient gene-targeting systems in oleaginous fungi for useful lipid production." Kyoto University, 2015. http://hdl.handle.net/2433/199371.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19047号<br>農博第2125号<br>新制||農||1032(附属図書館)<br>学位論文||H27||N4929(農学部図書室)<br>31998<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授小川順, 教授喜多恵子, 教授栗原達夫<br>学位規則第4条第1項該当

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9

Aldred, David. "The development of a solid-phase fermentation system for the production of pharmaceutically useful secondary metabolites in fungi." Thesis, Cranfield University, 2000. http://dspace.lib.cranfield.ac.uk/handle/1826/4652.

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A Phoma species, producing a squalestatin (Si) was grown on agar media derived from wheat, oats, oil seed rape and malt extract over a range of water availability values corresponding to water activity (aa) levels of. 0.998,0.995,0.990,0.980 and 0.960. Growth of the organism was not significantly affected by aw, except at the lowest value, but production of SI was significantly enhanced at intermediate aW in the range 0.990 - 0.980. For example, at 25°C and 0.98 aw wheat extract produced a l Ox increase in titre compared to 0.998 aw at the same temperature. Wheat extract was shown to be the be

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10

Harwoko, Harwoko [Verfasser]. "Metabolite Diversity of Endophytic Fungi Associated with Medicinal Plants / Harwoko Harwoko." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1232490032/34.

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11

Dupraz, Louise. "Régulation des lymphocytes T innés par le microbiote intestinal Enterobacteriaceae are essential for the modulation of colitis severity by fungi Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS598.

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Dès la naissance, un très grand nombre de micro-organismes commensaux tels que bactéries, levures et virus colonise le tractus gastro-intestinal humain. Ce microbiote intestinal est essentiel pour développer les défenses immunitaires de l'hôte contre les infections, permettre une réparation tissulaire et un métabolisme nutritionnel adéquat. Les lymphocytes T gamma-delta, ou lymphocytes T innés sont des cellules T résidentes dans les tissus, impliquées dans l’inflammation intestinale telle que les maladies inflammatoires chroniques de l’intestin (MICI). Placée à l’interface entre l’immunité inn

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12

Bloor, Stephen. "Investigation of extracellular metabolite production by cyanobacteria." Thesis, University of Central Lancashire, 1989. http://clok.uclan.ac.uk/20913/.

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13

Platt, Adam Samuel. "Identification of sequences in the regulatory gene areA responsible for modulating nitrogen metabolite repression in Aspergillus nidulans." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240910.

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14

Jensen, Paul Robert. "Marine actinomycete diversity, biogeography, and secondary metabolite production." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3204582.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed April 4, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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15

Hothersall, Joanne. "Metabolite production and molecular characterisation of interspecific Aspergilli." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285775.

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16

Höller, Ulrich. "Isolation, biological activity and secondary metabolite investigations of marine-derived fungi and selected host sponges." [S.l.] : [s.n.], 1999. http://www.gbv.de/dms/bs/toc/271061243.pdf.

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17

Morgan, F. J. "Optimisation of secondary metabolite production by an immobilised Streptomyces sp." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506641.

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18

Hu, Bizhen. "Metabolite Production in Callus Culture of Burdock (Arctium lappa L.)." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1357141954.

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19

Wynant, Inneke. "Heterologous expression systems for metabolite production during early drug research." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210070.

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La bio-transformation naturelle des médicaments peut produire des métabolites toxiques; l’identification de ces métabolites est essentielle dans la stratégie de choix de molécules thérapeutiques. En appliquant les technologies de fermentation en bioréacteur des cellules hétérologues (souches d’E. coli recombinantes exprimant une iso-enzyme de cytochrome P450 humain avec la réductase humain), la bioconversion du substrat (principe actif) en ses métabolites de dégradation, a été réalisée à grande échelle (&<br>Doctorat en Sciences<br>info:eu-repo/semantics/nonPublished

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20

Eskdale, Jocelyn Wendy. "Management of arbuscular mycorrhizal fungi (AMF) in intensive vegetable production /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16105.pdf.

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21

McCabe, Bernadette K., of Western Sydney Macarthur University, and Faculty of Business and Technology. "Production of cellulolytic enzymes using immobilised anaerobic fungi." THESIS_FBT_XXX_Mccabe_B.xml, 1998. http://handle.uws.edu.au:8081/1959.7/83.

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An investigation was made into the isolation and screening of highly cellulolytic anaerobic fungi and their production of cellulolytic enzymes using immobilised rhizomycelia. A total of 46 anaerobic fungi were isolated on cellulosic substrates from ruminant and non-ruminant herbivores. Primary screening of these isolates was performed using dye release from cellulose-azure which qualitatively detected cellulolytic activity. Twelve isolates were chosen on the basis of their maximum solubilisation rates of the labelled cellulose and then subjected to secondary screening which involved the quanti

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22

Frank, J. Michael. "The effect of agricultural biocides on metabolite production by Fusarium sporotrichioides." Thesis, University of Surrey, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277342.

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23

Bajhaiya, Amit. "Metabolite analysis of Chlamydomonas reinhardtii and transcriptional engineering for biofuel production." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/metabolite-analysis-of-chlamydomonas-reinhardtii-and-transcriptional-engineering-for-biofuel-production(185995ba-d1be-44ff-a87a-140c19655d31).html.

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It has been long known that algae have the potential to produce a diverse range of metabolic products including lipid and starch, which could be utilized as a fuel feedstock. Despite the capacity of algae to synthesize and store large amounts of lipids and starch, algae are not currently a commercially viable feedstock for biofuel. The metabolite storage in algae can depend on the availability of nutrients such that nutrient starvation can boost the storage of lipid and carbohydrate. These nutrient-status-induced changes in lipid and starch are underpinned by altered expression of several meta

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24

Towle, Jane Elizabeth. "AtrA-mediated transcriptional regulation in Streptomyces secondary metabolite production and development." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485160.

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Production of the tilue-pigmented polyketide antibiotic actinorhodin by Streptomyces co~licolor is controlled by transcriptional regulationof the pathway-specific gene actlIORF4. Previous work in our laboratory identified a member of the TetR-family of' transcriptional regulators, designated AtrA @ctinorhodin !ranscriptional regulator A), that can bind to two regions of the actlI-ORF4 promoter. Work in this thesis shows that disruption of atrA results in reduced levels of actinorhodin production. Furthermore, , QPCR analysis reveals the reduction is associated with diminished levels of actlI-O

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25

Rengifo, R. G. C. "Mycotoxin production in single and mixed microbial culture in cereal substrates." Thesis, University of Strathclyde, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381189.

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26

Cerff, Jeanne. "Optimisation of kefir biomass and metabolite production in conjunction with sensory evaluation." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52979.

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Thesis (MSc)--Stellenbosch University, 2002.<br>ENGLISH ABSTRACT: Developing countries such as South Africa are in dire need of nutritionally adequate dairy food and beverage sources that are ambient stable due to minimal access to refrigeration. One such product is Kefir, a naturally fermented milk beverage that originated in Caucasian China many centuries ago. The microorganisms responsible for fermentation of the milk are held together in a carbohydrate matrix in the form of small grains. These grains are then removed from the beverage prior to consumption, and added to fresh milk fo

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27

Hanlon, Amy. "Stress and release : chemical modulation of secondary metabolite production in Aspergillus sp." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37692.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2006.<br>Includes bibliographical references (leaf 18).<br>Cyclosporin A induced biosynthesis of colored compounds in three species of Aspergillus. Diode array HPLC MS analysis of culture extracts revealed Aspergillus terreus demonstrated the most profound response, with upregulation of more then twelve compounds from three distinct chemical families; butyrolactones, aspulvinones, and asterriquinones. Compounds from these three families are prenylated, and biosynthetically derived from homodimers of amino acids. The majo

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28

Moda, Musa Haruna. "Metabolite production and potential health effects of mould growth associated with buildings." Thesis, Glasgow Caledonian University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.688265.

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29

Praptiwi, Radisti Ayu. "Optimisation of high value metabolite production from benthic marine dinoflagellate Prorocentrum lima." Thesis, Robert Gordon University, 2014. http://hdl.handle.net/10059/1006.

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Toxins produced by harmful algal blooms (HABs) are known to pose contamination risks to seafood products (e.g. fish and shellfish) consumed by human. In order to control contamination risks, monitoring regimes have to be performed rigorously. The effort to monitor the amount of toxins in consumable products has to rely on continuous supply to analytical standards. The current work presents the strategy in optimising the production of major diarrhetic shellfish poisoning (DSP) toxins, OA and DTX1, from Prorocentrum lima. The organism is also known to produce peridinin, a carotenoid pigment that

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30

Yokochi, Toshihiro. "Industrial Production of γ-Linolenic Acid by Filamentous Fungi". Kyoto University, 1996. http://hdl.handle.net/2433/160873.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(農学)<br>乙第9392号<br>論農博第2097号<br>新制||農||733(附属図書館)<br>学位論文||H8||N2989(農学部図書室)<br>UT51-97-B329<br>(主査)教授清水昌, 教授加藤暢夫, 教授熊谷英彦<br>学位規則第4条第2項該当

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31

Rizzi, John. "Production of emulsifier by Torulopsis petrophilum." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=64014.

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32

Schilling, Jonathan S. "Oxalate Production and Cation Translocation during Wood Biodegredation by Fungi." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/SchillingJS2006.pdf.

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33

Soydan, Meltem. "Production Of Thermostable Beta-galactosidase From Tyhermophilic Fungi For Use In Low-lactose Milk Production." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607501/index.pdf.

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The aim of this research was the production of beta-galactosidase from thermophilic fungi for use in low lactose milk production or other possible applications. For this purpose, three thermophilic fungi Humicola insolens, Torula thermophila and Thermomyces lanuginosus were screened for lactase production. Highest lactase activity was observed in Thermomyces lanuginosus. The carbon source inducing highest extracellular lactase production in Thermomyces lanuginosus was determined as arabinose. When grown on arabinose T. lanuginosus produced two major lactase activity peaks, one being at day 4 (

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34

Trollope, Kim. "Investigation of resveratrol production by genetically engineered Saccharomyces cervisiae strains /." Link to the online version, 2006. http://hdl.handle.net/10019/1247.

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35

Sorrentino, Flavia. "Molecular Investigation of Quorum Sensing in Aspergillus species for enhancement of secondary metabolite production." Thesis, University of Westminster, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500559.

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36

Smith, Jonathan. "The physiological regulation of secondary metabolite production in a microbial culture with biocontrol activity." Thesis, University of Surrey, 1996. http://epubs.surrey.ac.uk/843098/.

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Antibiotic production kinetics of Streptomyces strain JS1 (an isolate selected from an industrial screen for biocontrol activity) and Streptomyces hygroscopicus (a culture collection strain with similar biocontrol activity to JS1) were examined. Growth-associated niphimycin production was observed in both strains during carbon-limited batch culture. Growth associated antibiotic production in carbon-limited medium has not been reported elsewhere and the antibiotic production physiology of biocontrol isolates has not been extensively studied in other laboratories. Increases in biomass and antibi

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37

Grassano, Stacie. "Whey-Based Fungal Microfactories for In Situ Production of Entomopathogenic Fungi." ScholarWorks @ UVM, 2008. http://scholarworks.uvm.edu/graddis/92.

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The eastern hemlock is a late-successional conifer species that is valued for its ecological functions, recreational importance, aesthetic beauty, and economic value. The hemlock woolly adelgid (HWA, Adelges tsugae Annand, Homoptera: Adelgidae) is an invasive aphid-like insect from Asia that is causing serious damage to the eastern and Carolina hemlock. HWA was first introduced to the Eastern United States to Virginia in the 1950’s and has since moved along the east coast from Georgia to Maine. It can kill a healthy tree in three to seven years depending on many environmental factors. Na

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38

LAZZARO, IRENE. "THE SUPPORT OF GENE EXPRESSION IN UNDERSTANDING SECONDARY METABOLITE PRODUCTION AND ECOLOGY IN FUSARIUM VERTICILLIOIDES." Doctoral thesis, Università Cattolica del Sacro Cuore, 2012. http://hdl.handle.net/10280/1308.

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Il tema principale di questa tesi di dottorato verte sul metabolismo secondario di F. verticillioides, con particolare interesse alla via biosintetica, produzione e mascheramento delle fumonisine B (FB), fumonisine A (FA), fumonisine C (FC) e bikaverina, studiati in relazione all’ecologia fungina. E’ stato osservato che l’acqua libera (aw) esercita un effetto significativo maggiore rispetto alla temperatura sul metabolismo secondario di F. verticillioides. Alti valori di aw favoriscono l’espressione dei geni FUM ed una maggiore sintesi delle FB, FA e FC. Inoltre la produzione di bikaverina e l

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39

Vilalta, Baliellas Elisabet. "Structure and Function in Fluvials Biofilms. Implications in River DOC Dynamics and Nuisance Metabolite Production." Doctoral thesis, Universitat de Barcelona, 2004. http://hdl.handle.net/10803/1430.

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The role of natural biofilms affecting the water quality in rivers has been the main theme in this study. Firstly, the study developed the capacity of biofilms in retention and/or production of DOC. Secondly, the study also approached the production of the geosmin metabolite by benthic cyanobacterial mats. In the two developed aspects, the structure and function of the biofilms showed their relevance in evaluating the capacity of biofilms on the amelioration of the water quality. The importance of the biofilms on ecological research in running waters has been focus in their capacity of adsorpt

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40

Cousins, Matthew M. "Development of in vitro protocols to enhance secondary metabolite production from turmeric (Curcuma longa L.)." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1211387234/.

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41

Hiscox, Jennifer. "Interspecific interactions between saprotrophic basidiomycetes : effects on ligninolytic enzyme activity, gene expression and metabolite production." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54974/.

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Interspecific antagonism leads to morphological, biochemical and transcriptional changes in the competing mycelia. Several approaches were used to study interactions: enzyme assays, staining, expression of ligninolytic genes, and analysis of volatile organic compounds (VOCs). Laccase and manganese peroxidase (MnP) activities were assayed, and transcript levels of laccase, Mn-repressed peroxidase (MRP), LiP and catalase measured by RT-PCR during interactions between Trametes versicolor and other wood decay fungi on agar plates. Increased laccase activity occurred in all interactions, irrespecti

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42

Singh, Nashveer. "Influence of fungal diversity and production of cellulolytic enzymes on decay of stored bagasse." Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-02102009-124245.

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43

Özmen, Nilgül. "Lignin based adhesives for particleboard production." Thesis, Bangor University, 2000. https://research.bangor.ac.uk/portal/en/theses/lignin-based-adhesives-for-particleboard-production(38b5f43f-c055-4156-b03c-492391d66d59).html.

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The purpose of this study was to utilise lignin as a partial substitute for phenol in PF resins. To achieve this, initially brown rot lignin was produced by a bioconversion technique. During the course of the study, it became clear that the production of brown rot lignin had a limited success. Since brown rot lignin could not be obtained in sufficient quantity and purity by a bioconversion method, other alternative lignin production methods, as well as commercially available lignin, were chosen; namely production of lignin from black liquor and Alcell® (organosolv) lignin. Before performing pr

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44

Mutabaruka, Rose Mangula. "Degradation of polyphenol-protein complexes by fungi in different tropical production systems." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415333.

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45

Amache, Rana. "Quorum sensing for improved production of industrially useful products from filamentous fungi." Thesis, University of Westminster, 2014. https://westminsterresearch.westminster.ac.uk/item/8y9x2/quorum-sensing-for-improved-production-of-industrially-useful-products-from-filamentous-fungi.

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Quorum sensing (QS) is a cell density dependant phenomena utilized as a communication process among microorganisms to regulate their physiological responses. QS depends on the production and release of low molecular weight, diffusible chemical signalling molecules, known as quorum sensing molecules (QSM) in the extracellular milieu. When the concentrations of the QSMs reach a critical threshold corresponding to a particular cell density, they bind to a receptor enabling them to function as transcriptional regulators. QS is widely studied in Gram-positive and Gram-negative bacteria in addition

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46

Ngiam, Celina. "Characterisation of a foldase in the protein secretory pathway of Aspergillus niger." Thesis, University of East Anglia, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266738.

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47

Asif, Mohammad. "Comparative study of production, infectivity, and effectiveness of arbuscular mycorrhizal fungi produced by soil-based and soil-less techniques /." [Campbelltown, N.S.W. : The Author], 1997. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030716.094919/index.html.

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48

Kern, Fredy [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Myxobacterial P450s as drug metabolizers : derivatization and metabolite production of drugs / Fredy Kern. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1109790236/34.

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49

Dalal, Pankaj. "Étude physiologique et cinétique de la production des enzymes cellulolytiques chez Trichoderma reesei en culture continue." Paris 11, 1989. http://www.theses.fr/1989PA112091.

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Cette étude vise à une meilleure connaissance de la production des enzymes cellulolytiques par le champignon cellulolytique Trichoderma reesei en culture submergée et à une meilleure compréhension des mécanismes de synthèse et de régulation de ces enzymes. La cinétique de la croissance et la production des enzymes cellulolytiques chez T. Reesei CL-847, mutant résistant à la répression catabolique et hyper producteur, ont été étudiées en culture continue limitée par le lactose, seule source de carbonne, et inducteur du système cellulolytique, et comparées à celles de la souche parentale T. Rees

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50

Bérubé, Esther. "The production of phenol oxidases by white-rot fungi in submerged liquid culture /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79999.

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Three species of white-rot fungi, Phlebia radiata, Phanerochaete chrysosporium, and Trametes versicolor, were monitored for laccase and lignin peroxidase production in a defined medium. P. radiata was selected for fed-batch reactor experiments due to its early laccase production, which was determined to be growth-associated. A second peak in laccase activity was observed after several days of nutrient deprivation and was attributed to autolysis of the culture. The effect of protease activity on the accumulation of extracellular laccase activity differed during primary and secondary meta

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