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Dissertations / Theses on the topic 'Metabolite profiles'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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1

De, Witt Riaan Neethling. "Correlating metabolite and transcript profiles in transgenic sugarcane lines." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80286.

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Thesis (MSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: See item for full abstract<br>AFRIKAANS OPSOMMING: Sien item vir volteks<br>IPB, National Research Foundation (NRF) and SASRI for funding
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2

Moncivaiz, Jessica. "Differences in fecal metabolite profiles from geographically distinct populations of adolescents." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1452675142.

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3

Barchet, Genoa L. H. "Effects of drought stress on metabolite profiles of hybrid and pure lines of Populus spp." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/25342.

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Drought stress is perhaps the most commonly encountered abiotic stress plants experience in the natural environment, and is one of the most important factors limiting plant productivity. In the studies described in this text, drought-stressed poplar trees (Populus spp.) were analyzed for their metabolite content using the technique of untargeted metabolite profiling by employing gas chromatography coupled to mass spectrometry (GC/MS). The purpose of these analyses was to characterize the metabolite profile of poplar trees under drought stress in order to assess relative drought resistance and
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4

Bell, Kathryn Laura. "Analysis of secondary metabolite gene and protein expression profiles in Streptomyces coelicolor grown under environmental conditions." Thesis, Swansea University, 2012. https://cronfa.swan.ac.uk/Record/cronfa42693.

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Streptomycetes are Gram positive, soil dwelling filamentous bacteria, known for their production of secondary metabolites. Genome sequencing of Streptomyces coelicolor identified 26 known or predicted secondary metabolite gene clusters ranging from antibiotics to siderophores, lipids, pigments and lantibiotics. Most studies investigating secondary metabolite production in Streptomyces, as well as other bacteria, are undertaken in liquid or on solid media. There is little gene expression data available from in situ studies. This study determined expression in a totally different growth medium,
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Jansen, Kirstin. "Stable Isotopes and Metabolite Profiles as Physiological Markers for the Drought Stress Sensitivity in Douglas-Fir Provenances (Pseudotsuga menziesii (MIRB.) FRANCO)." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19617.

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In Mitteleuropa werden zukünftig häufigere Trocken- und Hitzeperioden mit wirtschaftlichen Einbußen in der Waldwirtschaft erwartet. Die Douglasie (Pseudotsuga menziesii (Mirb.) Franco) wird als Alternative für die wirtschaftlich bedeutsame, jedoch trockenheitsempfindliche Fichte diskutiert (Picea abies (L.) H.Karst.). Zwei Unterarten, die Küsten- (FDC) und die Inlandsdouglasie (FDI), sind im ausgedehnten natürlichen Verbreitungsgebiet in Nordamerika beheimatet, welches ein großes Potenzial für die Auswahl produktiver und trockenresistenter Herkünfte bietet. Unser Ziel war, die Trockenreaktion
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6

Kaling, Moritz Verfasser], Philippe [Akademischer Betreuer] [Gutachter] Schmitt-Kopplin, Jörg-Peter [Gutachter] [Schnitzler, and Michael [Gutachter] Rychlik. "Mass-spectrometric characterization of stress-induced metabolite profiles in poplar / Moritz Kaling ; Gutachter: Jörg Peter Schnitzler, Philippe Schmitt-Kopplin, Michael Rychlik ; Betreuer: Philippe Schmitt-Kopplin." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1122482124/34.

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7

Jansen, Kirstin [Verfasser], Arthur [Gutachter] Gessler, Ralf [Gutachter] Kätzel, and Andreas [Gutachter] Rigling. "Stable Isotopes and Metabolite Profiles as Physiological Markers for the Drought Stress Sensitivity in Douglas-Fir Provenances (Pseudotsuga menziesii (MIRB.) FRANCO) / Kirstin Jansen ; Gutachter: Arthur Gessler, Ralf Kätzel, Andreas Rigling." Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1184576890/34.

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8

Zhou, Chenguang [Verfasser], Karl-Heinz [Akademischer Betreuer] Engel, Karl-Heinz [Gutachter] Engel, and Philippe [Gutachter] Schmitt-Kopplin. "Impact of Cross-Breeding on the Phytic Acid Contents and the Metabolite Profiles of Low Phytic Acid Rice (Oryza sativa L.) Mutants / Chenguang Zhou ; Gutachter: Karl-Heinz Engel, Philippe Schmitt-Kopplin ; Betreuer: Karl-Heinz Engel." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1186256664/34.

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9

Goßner, Sophia Karolina [Verfasser], Karl-Heinz [Akademischer Betreuer] Engel, Karl-Heinz [Gutachter] Engel, and Michael [Gutachter] Rychlik. "Impact of Cross-Breeding on the Contents of Inositol Phosphate Isomers and the Metabolite Profiles of Low Phytic Acid Soybean (Glycine max (L.) Merr.) Mutants / Sophia Karolina Goßner ; Gutachter: Karl-Heinz Engel, Michael Rychlik ; Betreuer: Karl-Heinz Engel." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1192911601/34.

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10

Norris, Teresa Emilea. "Metabolomics /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/norrist/teresanorris.pdf.

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11

Schmidt, Julie Andersen. "Epidemiology of metabolite profile and prostate cancer risk." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:468ca322-16a3-4f61-8fcc-bac9b918300c.

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Insulin-like growth factor-I (IGF-I) is the only known potentially modifiable risk factor for prostate cancer. Intake of dietary protein, especially from dairy products, might also be associated with risk and with circulating IGF-I, but it is not clear if amino acids play a role in these relationships. Moreover, investigations of circulating concentrations of metabolites might reveal novel risk factors for prostate cancer. This thesis investigates plasma concentrations of amino acids and other metabolites in relation to protein intake, IGF-I, and prostate cancer risk using data from the Europe
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12

Masson, Perrine Anne Sophie. "Cytochrome P450 profiles in rat and their prediction from UPLC-MS metabolic profiles." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9240.

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Cytochrome P450 enzymes (CYPs) are of great interest to pharmaceutical industry due to their major role in drug metabolism and drug-drug interactions in man. As CYPs also act on endogenous substrates and are regulated by nuclear receptors involved in biochemical pathways, their profiles are likely to affect endogenous metabolic profiles. The work in this thesis aimed to establish baseline rat liver CYP levels and assess relationships between CYP profiles and corresponding endogenous metabolic profiles, before introducing CYP inducers in subsequent projects to identify early biomarkers of CYP i
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13

Augustyn, WA, JE Maree, Plooy GW du, BM Botha, and S. Combrinck. "Effect of secondary metabolites on gall fly infestation of mango leaves." Wiley InterScience, 2010. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001216.

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Abstract Themango gall fly (Procontarinia) is a growing concern in many countries that importmango trees.Mangoes flush (produce opening buds) twice a year: once in spring, and the main flush, which occurs in early autumn flush and corresponds to the photoperiod necessary for the gall fly to emerge. Gall flies attack only very young mango flush leaves. Three cultivars displaying varying susceptibility were used in this study: Heidi, which typically is heavily infected; Keitt, which displays antixenosis properties; and Sensation, which is resistant to gall fly attack. Headspace profiles of the t
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14

Alves, Alexessander Da Silva Couto. "Bioinformatics methods for the analysis of metabolic profiles." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534966.

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15

Al-Mugalli, Abdul Aziz Mohammed. "The use of metabolic profiles in sheep husbandry." Thesis, Royal Veterinary College (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399734.

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16

Penailillo, Luis. "Muscle damage and metabolic profiles of eccentric cycling." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/706.

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Eccentric cycling, in which the knee extensor muscles perform eccentric contractions while trying to brake the backward rotational movements of the cranks of a cycle ergometer, has been shown to effectively increase muscle function and volume with a low metabolic cost. However, acute responses to repeated eccentric cycling bouts have not been well documented. Thus, the primary purposes of this PhD project were to investigate muscle damage and metabolic profiles of eccentric cycling in comparison to concentric cycling (Studies 1-3), and muscle-tendon behaviour (Study 4) during eccentric cycling
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17

Kumaran, A. "Neuroimaging, cognitive and metabolic profiles in children with hypoglycaemia." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1405622/.

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Background: Glucose is a major fuel for brain function, and persistent and recurrent hypoglycaemia of any aetiology can cause brain injury. Children with hyperinsulinaemic hypoglycaemia (HH) are at a high risk of brain injury, as the inappropriate secretion of insulin during hypoglycaemia inhibits lipolysis thereby reducing the availability of ketone bodies (KB) that are an important source of alternate fuel for the brain during hypoglycaemia. In contrast children with ketotic hypoglycaemia (KH) are believed to be neurologically protected, due to the presence of abundant ketone bodies during h
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18

Doehring, Orlando. "Peak selection in metabolic profiles using functional data analysis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11062.

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In this thesis we describe sparse principal component analysis (PCA) methods and apply them to the analysis of short multivariate time series in order to perform both dimensionality reduction and variable selection. We take a functional data analysis (FDA) modelling approach in which each time series is treated as a continuous smooth function of time or curve. These techniques have been applied to analyse time series data arising in the area of metabonomics. Metabonomics studies chemical processes involving small molecule metabolites in a cell. We use experimental data obtained from the COnsor
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19

Mantovani, Cristina de Faria. "Análise metabolômica (1H RMN) do líquido sinovial de equinos hígidos e acometidos por osteocondrite dissecante." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-10042014-144355/.

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A osteocondrite dissecante (OCD) é uma das principais doenças que afetam os equinos jovens e uma das condições incluídas nas Doenças Ortopédicas do Desenvolvimento. Por se tratar de importante afecção articular, a OCD pode ser responsabilizada por perdas econômicas substanciais em decorrência da diminuição do desempenho atlético e reprodutivo dos animais acometidos. Sua etiologia é considerada multifatorial sendo associada a fatores nutricionais, endócrinos, genéticos e biomecânicos. A análise dos biomarcadores do líquido sinovial fornece dados fundamentais acerca das alterações representativa
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20

Nygård, Emma. "Characterizing substances into pharmacological classes using theirmorphological and metabolic profiles." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349009.

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Treatment of cancers has been improved and new findings in research communities areconstantly found, but there are still many questions about how to treat these complex diseases.One way to treat cancer is to expose cancer cells to drugs that kill the cancer cells to a largerextent than the normal cell from the same as well as other tissue types. Different drugcompounds have diverse molecular effects on the cancer cells and to evaluate them, studies ondifferent cell lines were performed.Experiments were performed to study morphological and metabolic changes on treatedcells. Morphological change
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21

Li, Zheng. "Integrating gene expression and metabolic profiles to optimize cellular functions." Diss., Connect to online resource - MSU authorized users, 2006.

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Thesis (Ph. D.)--Michigan State University. Dept. of Chemical Engineering and Materials Science, 2006.<br>Title from PDF t.p. (viewed on June 19, 2009) Includes bibliographical references (p. 166-180). Also issued in print.
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22

PREMI, MICHELE. "SVILUPPO DELL'INDICE DI BENESSERE SDIB PER BOVINE DA LATTE FINALIZZATO ALL'OTTIMIZZAZIONE DEGLI ALLEVAMENTI." Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/67852.

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Dalla panoramica dei sistemi di valutazione del Benessere Animale (BA) si evince che si basa su molteplici indicatori diretti ed indiretti, ma per tutti i sistemi esaminati non vi è mai la possibilità di confermare la stima di benessere con metodi di riferimento oggettivi ed indipendenti. Inoltre, i vari sistemi, pur volendo stimare un dato oggettivo del BA, rispondono a specifiche categorie sociali: opinione pubblica (es. Welfare Quality), politica amministrativa (es. IBA), allevatori (es. FARM, IBS e SDIB), consumatori (FARM, Welfare Quality). Un sistema realmente olistico al momento non esi
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PREMI, MICHELE. "SVILUPPO DELL'INDICE DI BENESSERE SDIB PER BOVINE DA LATTE FINALIZZATO ALL'OTTIMIZZAZIONE DEGLI ALLEVAMENTI." Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/67852.

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Dalla panoramica dei sistemi di valutazione del Benessere Animale (BA) si evince che si basa su molteplici indicatori diretti ed indiretti, ma per tutti i sistemi esaminati non vi è mai la possibilità di confermare la stima di benessere con metodi di riferimento oggettivi ed indipendenti. Inoltre, i vari sistemi, pur volendo stimare un dato oggettivo del BA, rispondono a specifiche categorie sociali: opinione pubblica (es. Welfare Quality), politica amministrativa (es. IBA), allevatori (es. FARM, IBS e SDIB), consumatori (FARM, Welfare Quality). Un sistema realmente olistico al momento non esi
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24

Cooke, Juliette. "Prédiction in silico de profils métaboliques pour améliorer la découverte des biomarqueurs et le phénotypage métabolique." Electronic Thesis or Diss., Toulouse, INPT, 2023. http://www.theses.fr/2023INPT0137.

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Le phénotypage métabolique humain permet de déceler des dérives physiologiques anormales via des molécules circulantes dans les biofluides (plasma, urines). Ces profils métaboliques peuvent être obtenus par des dosages cliniques classiques (petit nombre ciblé de molécules) ou par une approche plus globale visant à mesurer sans a priori une gamme large de molécules endogènes : la métabolomique. La métabolomique ne permet pas de couvrir avec une seule technique analytique l’ensemble du métabolome humain. Il est donc indispensable de planifier et d’optimiser les expériences de métabolomique pour
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25

Provan, Anne. "Systematic chemical screening of mircroalgae." Thesis, University of Strathclyde, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366955.

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26

Fiore, Enrico. "Risposta del test da carico del glucosio sul profilo metabolico e valutazione isto-patologica di campioni bioptici in bovine da latte nel periodo di transizione." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423650.

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Objectives of this study were to determine effects of time relative to calving and health status on blood metabolite concentrations after glucose tolerance test (GTT) and to investigate on the severity and on the distribuition of periparturient fatty change liver (FCL). Metabolic profiles were performed on plasma samples collected from 40 cows selected from 2 dairy farms. GTT and Blood sampling was carried out 7±5 d before and 7±5 d after the calving. Glucose was administrated intravenously in a 50% solution at a dose of 0,25 g/Kg. Blood samples were collected before (T0) and after the begin
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Fitzpatrick, Martin Antony. "Do differentiated macrophages display distinct metabolic profiles reflecting their different functions?" Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7036/.

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Macrophages are key players in both regulatory and inflammatory immune responses. They are implicated in the pathogenesis of rheumatoid arthritis (RA) where they accumulate in the synovium and produce pro-inflammatory cytokines including TNFα and IL-6. The rheumatoid synovium is metabolically distinctive, with low oxygen perfusion and high concentrations of lactate and reactive oxygen species (ROS). Macrophages are known to respond to metabolic signals, therefore we wanted to explore whether metabolic phenotypes of differentiated macrophages could play a role in the persistence of RA. We used
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Fonville, Judith Marlou. "Development and application of chemometric methods for modelling metabolic spectral profiles." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6952.

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The interpretation of metabolic information is crucial to understanding the functioning of a biological system. Latent information about the metabolic state of a sample can be acquired using analytical chemistry methods, which generate spectroscopic profiles. Thus, nuclear magnetic resonance spectroscopy and mass spectrometry techniques can be employed to generate vast amounts of highly complex data on the metabolic content of biofluids and tissue, and this thesis discusses ways to process, analyse and interpret these data successfully. The evaluation of J -resolved spectroscopy in magnetic re
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Underhill, Brian Kimball. "The influence of Leptin on metabolic expenditure and thermogenesis during thyroid hormone (T₃) suppression in the obese (OB/OB) mouse." CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1767.

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30

Wellbery, Laura Mary. "RELATIONSHIP BETWEEN CHANGES IN MAXIMAL AEROBIC CAPACITY AND METABOLIC PROFILES IN OBESE YOUTHS." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1056994003.

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31

Parkinson, Nicola. "Development of a mass spectral database to profile metabolite changes in cerebrospinal fluid." Thesis, Parkinson, Nicola (2014) Development of a mass spectral database to profile metabolite changes in cerebrospinal fluid. Honours thesis, Murdoch University, 2014. https://researchrepository.murdoch.edu.au/id/eprint/25402/.

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Alzheimer’s disease is an incurable chronic neurodegenerative disease that results in severe memory loss and cognitive function. It is the third most common cause of death and the most common cause of dementia in the developed world. To date, a number of possible causes have been identified, however the primary cause is still unknown. Diagnosis generally does not occur until the later stages, resulting in insufficient treatment to reverse any damage. Metabolomic analysis is a relatively new technique that aims to identify all metabolites present in a biological sample, which could potentially
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Corbin, Anne Elizabeth. "Metabolic and behavioral profiles in mice with a Deaf-1 haploinsufficient background /." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1885442071&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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33

BahaaAldeen, Al-Trad. "Effects of Increasing Intravenous Glucose Infusions on Lactation Performance, Metabolic Profiles, and Metabolic Gene Expression in Dairy Cows." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-38233.

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Knowledge on the precise effects of surplus glucose supply in dairy cows is limited by the lack of information on how intermediary metabolism adapts at different levels of glucose availability. Therefore, a gradual increase of glucose supply via intravenous glucose infusion was used in the present study to test the dose effect of surplus provision of glucose on the metabolic status and milk production of dairy cows. Furthermore, the effects of increasing levels of surplus glucose on mRNA expressions and activities of rate-limiting enzymes involved in hepatic gluconeogenesis were investigated.
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Pereira, Cécile. "Nouvelles approches bioinformatiques pour l'étude à grande échelle de l'évolution des activités enzymatiques." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112065/document.

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Cette thèse a pour objectif de proposer de nouvelles méthodes permettant l'étude de l'évolution du métabolisme. Pour cela, nous avons choisi de nous pencher sur le problème de comparaison du métabolisme de centaines de micro-organismes.Afin de comparer le métabolisme de différentes espèces, il faut dans un premier temps connaître le métabolisme de chacune de ces espèces.Les protéomes des micro-organismes avec lesquels nous souhaitons travailler proviennent de différentes bases de données et ont été séquencés et annotés par différentes équipes, via différentes méthodes. L'annotation fonctionnel
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LOREGGIAN, LARA. "MEDITERRANEAN DIET RESHAPES PERIPHERAL SECRETOME AND LIPIDOME PROFILES IN PATIENTS WITH METABOLIC SYNDROME." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/783295.

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La perdita di peso nei pazienti con sindrome metabolica ha effetti positivi sulle malattie cardiovascolari e sul rischio di diabete di tipo 2, ma i suoi effetti sul profilo lipidico e sul secretoma periferico sono tutt’ora poco chiari. Al fine di determinare gli effetti della perdita di peso indotta dalla dieta sui parametri metabolici sono stati analizzati il profilo lipidico e il secretoma periferico in pazienti affetti da sindrome metabolica. In questo studio sono stati arruolati 18 soggetti adulti di sesso maschile con sindrome metabolica e BMI compreso tra 25 e 35 Kg/m2, che sono stati s
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Фадєєва, Ганна Анатоліївна, Анна Анатольевна Фадеева, Hanna Anatoliivna Fadieieva, Ольга Миколаївна Чернацька, Ольга Николаевна Чернацкая, and Olha Mykolaivna Chernatska. "Improving of Metabolic Profile With Vitamin D Supplements in Pregnant Women." Thesis, Elsevier, 2021. https://essuir.sumdu.edu.ua/handle/123456789/83387.

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Background. Serum 25-hydroxy-vitamin D deficiency is related to metabolic diseases as polycystic ovary syndrome, obesity, insulin resistance, cardiovascular diseases, cancer, gestational diabetes mellitus (GDM). Objective: To evaluate the effect of vitamin D therapy on metabolic parameters in pregnant women. Methods: There was a 16-week study of 62 participants with gestational diabetes mellitus. All pregnant women followed an appropriate diet and physical activity. Management of 37 women included 2,000 IU/day of cholecalciferol per os. Body mass index (BMI), hemoglobin A1c (HbA1c), fasting pl
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BERTAGNOLI, STEFANO. "Improving robustness and metabolic profile of saccharomyces cerevisiae for industrial bioprocesses." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/28926.

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The fossil energy resources decrease and climate changes, caused by carbon dioxide (CO2) emissions, have led most industrialized countries to undertake policies aimed at the development and use of renewable energy sources. Among the renewable energies, vegetal biomasses play a key role because widely available and potentially able to cover up to 200% of the global energy demand. Vegetal biomasses can be used mainly as raw materials for the production of chemicals, biofuels and energy, in the increasingly important green economy concept based on biorefineries creation. Although the vegetal biom
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Adua, Eric. "N-Glycosylation profiles as a risk stratification biomarker for Type II Diabetes Mellitus and its associated factors." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2162.

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Worldwide, the prevalence of cardiometabolic diseases, particularly type II diabetes mellitus (T2DM), and to a lesser extent, metabolic syndrome (MetS), has increased dramatically. Despite this increase, there is still a lack of robust biomarkers for cardiometabolic diseases to secure better clinical outcomes. The enzymatic attachment of oligosaccharides (glycans) to proteins-glycosylation is of metabolic and physiological significance, as exploring aberrations of glycosylation profiles can reveal novel biomarkers. In parallel, this process could also explain the biological mechanisms that und
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Pedersen, Mark R., Amit Patel, David Backstedt, Myunghan Choi, and Anil B. Seetharam. "Genotype specific peripheral lipid profile changes with hepatitis C therapy." BAISHIDENG PUBLISHING GROUP INC, 2016. http://hdl.handle.net/10150/622597.

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AIM To evaluate magnitude/direction of changes in peripheral lipid profiles in patients undergoing direct acting therapy for hepatitis C by genotype. METHODS Mono-infected patients with hepatitis C were treated with guideline-based DAAs at a university-based liver clinic. Patient characteristics and laboratory values were collected before and after the treatment period. Baseline demographics included age, ethnicity, hypertension, diabetes, hyperlipidemia, treatment regimen, and fibrosis stage. Total cholesterol (TCHOL), high density lipoprotein (HDL), low density lipoprotein (LDL), triglycerid
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Lo, Presti Caroline. "Reprogrammation métabolique dans les leucémies aigues myéloblastiques (LAM) : Impact clinique et mécanismes oncogéniques De novo adult acute myeloid leukemia patients display at diagnosis functional deregulation of redox balance correlated with molecular subtypes and overall survival." Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALV017.

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Le métabolisme des cellules cancéreuses est fortement perturbé et dérégulé dans les cancers. Plusieurs exemples illustrent ce phénomène, notamment la reprogrammation métabolique décrite dans l’effet Warburg, les dérégulations fonctionnelles de certaines voies métaboliques telles que l’augmentation de la production de ROS dans les cellules cancéreuses, ou la mise en évidence d’oncométabolites liés à des mutations acquises telles que les mutations IDH1/2 qui entraînent la production d’un métabolite directement associé au processus leucémique dans les LAM. Afin de caractériser les reprogrammation
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Johnson, Eric Eugene. "A profile of the expression of a metabolic gene cluster in Arabidopsis." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42802.

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Plant cells often display a microtubule reorganization event when encountered with stress. This has been found to be integral for the reaction to stresses such as aluminum toxicity and cold stress. A cDNA microarray was previously conducted that identified MARNERAL SYNTHASE (MRN1), an oxidosqualene cyclase that produces the triterpene marneral, as the most highly upregulated gene when microtubule dynamics are disrupted in Arabidopsis. This work identifies two cytochrome P450s, CYP71A16 and CYP705A12, that are highly coregulated with MRN1 and are located within close proximity to the MRN1 lo
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Kyrana, Eirini. "Body composition and metabolic profile of children with end stage liver disease." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/body-composition-and-metabolic-profile-of-children-with-end-stage-liver-disease(b201b845-3bbc-4d41-ac27-6080c94235b8).html.

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Children with end stage liver disease are thought to have reduced lean mass and higher energy requirements. The aim of the study was to assess how body composition and energy requirements of children with end stage liver disease differ from those of healthy children and how they change after liver transplantation as well as to study for metabolic pathways that may be influencing the body composition. Body composition was assessed by various methods including basic anthropometry, stable isotopes, dual-energy X-ray absorptiometry (DXA) and air displacement plethysmography (BOD POD). Resting ener
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Anyorigiya, Thomas Atingane. "Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27301.

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RATIONALE: The accurate measurement of antimalarial drug concentrations in key target patient groups is essential to ensure optimal dosing for malaria treatment and to distinguish between inadequate drug exposure and antimalarial resistance. METHODS: A sensitive and selective liquid chromatography-tandem mass spectrophotometric method was developed and validated for the simultaneous determination of amodiaquine and its active metabolite, desethylamodiaquine in 20μl heparinised human capillary whole blood and capillary plasma. During validation no significant matrix effects were observed for th
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Ryan, Declan John. "The modulatory effects of sedentary behaviour and physical activity on older adults' cardiovascular/metabolic profiles." Thesis, Manchester Metropolitan University, 2018. http://e-space.mmu.ac.uk/621553/.

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Cardiovascular disease (CVD) is the greatest cause of mortality, after cancer, in older adults (>60 years). CVD risk can be modulated by sedentary behaviour (SB) and physical activity (PA) however, research examining the effect of SB and PA on older adults' cardiovascular/metabolic profile is lacking. This thesis aimed to address this gap in the literature. Ninety-three independently living older adults wore a thigh-mounted triaxial accelerometer for 7 consecutive days to assess habitual SB and PA engagement and patterns. Fasting blood samples to assess seven cardiometabolic marker concentrati
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Athanassiadis, Aristide. "Towards more comprehensive urban environmental assessments: Exploring the complex relationship between urban and metabolic profiles." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/232139/5/contrataa.pdf.

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Urban areas cover 2% of the Earth’s land surface, host more than 50% of global population and are estimated to account for around 75% of CO2 emissions from global energy use. In order to mitigate existing and future direct and indirect environmental pressures resulting from urban resource use, it is necessary to investigate and better understand resource and pollution flows associated with urban systems.Current urban environmental assessment methodologies enable the quantification of resource use and pollution emissions flows entering, becoming stocked and exiting urban areas. While these meth
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Foreman, III Richard A. "Enzymatic profiles of skeletal muscles from harbor seals (Phoca vitulina) and fin whales (Balaenoptera physalis)." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30808.

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The enzymatic organization of muscle tissue usually is examined in only a select few muscles of any one animal species. However, because the functional demands placed on individual muscles can vary so widely from muscle to muscle, it is inappropriate to generalize findings from one or two muscles to muscle tissue in general. The differences or similarities in metabolic machinery between skeletal muscles of a wide functional range provides crucial information with respect to a particular animals' whole body metabolism. Nowhere is this understanding more important than in the diving marine mamma
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DeGroat, Ashley R., W. Andrew Clark, Kendra L. Hagood, and Jonathan M. Peterson. "CTRP3 Alters Lipid Profile in Response to Ethanol Feeding." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2509.

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Won, Samantha Gwai Lan. "Acute and chronic heat stress alters the metabolic profile of skeletal muscle in growing swine." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/34515.

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Heat stress (HS) causes significant losses to the U.S. swine industry in several production and health areas including efficient lean tissue accretion. Perturbations in skeletal muscle metabolism may participate in this defect. The study objectives were to examine the cellular bioenergetic profile in skeletal muscle of piglets subjected to thermal stress in utero and/or during postnatal life. To accomplish this, 96 offspring from 14 sows were prenatally exposed to 1 of 4 environmental treatments involving thermal neutral (TN, 25°C) or HS conditions (cyclical 28-34°C). Sows exposed to TN or
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Rydzak, Thomas. "Integration of Genome Content, Enzyme Activities, and Expression Profiles in Assessing Changes in End-Product Yields in Clostridium thermocellum." Journal of Biotechnology, 2009. http://hdl.handle.net/1993/22280.

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Clostridium thermocellum is a fermentative, Gram-positive, thermophile capable of cellulosome-mediated breakdown of hemicellulose and simultaneous biofuels (ethanol and H2) production, and is thus an excellent candidate for consolidated bioprocessing. However, ethanol and/or H2 production yields are below theoretical maxima due to branched product pathways. Biofuel yields may be improved by manipulation of fermentation conditions or implementation of rational metabolic engineering strategies. However, the latter relies on a thorough understanding of gene content, gene product expression, en
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Slocombe, Stephen Peter. "Changes in enzyme profile during the induction of crassulacean acid metabolism in Mesembryanthemum crystallinum." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/35351.

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