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Journal articles on the topic 'Metadoxine'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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1

Addolorato, G., C. Ancona, E. Capristo, and G. Gasbarrini. "Metadoxine in the Treatment of Acute and Chronic Alcoholism: A Review." International Journal of Immunopathology and Pharmacology 16, no. 3 (2003): 207–14. http://dx.doi.org/10.1177/039463200301600304.

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Alcohol abuse and alcoholism are responsible for a wide variety of medical problems. The pharmacotherapeutic aspect of alcoholism includes the use of drugs, with different actions and objectives. Among them, metadoxine seems to be of interest. Metadoxine is able to accelerate the elimination of alcohol from the blood and tissues, to help restore the functional structure of the liver and to relieve neuro-psychological disorders associated with alcohol intoxication. Metadoxine also seems to be safe; in more than 15 years of post-marketing surveillance only minor aspecific and reversible events w
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2

Bermúdez-Duarte, Paula María, and José Alfredo Rivera-Rojas. "Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases." Revista MVZ Córdoba 28, no. 3 (2023): e3103. http://dx.doi.org/10.21897/rmvz.3103.

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Objective. To evaluate the effect of Metadoxine on paraclinical, ultrasound, and histopathological findings in canines with primary hepatopathies through a number of cases. Materials and Methods. Seven dogs aged 2 to 14 years with mild to moderate clinical signs of primary hepatopathy, abnormal bile acids, increased ALT or ALP values three times above the upper range for 4 weeks, underwent ultrasound evaluation and ultrasound-guided Tru-Cut liver biopsy to confirm hepatopathy according to the histological classification of the WSAVA. Prior to the biopsy, they were required to have fibrinogen &
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3

JIN, WeiHua, BoTao YU, Hua CHEN, Ming ZHANG, ZhiQiang PU, and WenYi LIAO. "Preparation and content determination of metadoxine suppository." Pharmaceutical Care and Research 2014, no. 04 (2014): 280–82. http://dx.doi.org/10.5428/pcar20140414.

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4

Didenko, V. I., I. A. Klenina, O. I. Hrabovska, et al. "Liver structure and fibrosis markers in modeling alcohol-induced liver injury and correction of detected disorders." GASTROENTEROLOGY 57, no. 3 (2023): 147–53. http://dx.doi.org/10.22141/2308-2097.57.3.2023.553.

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Background. Chronic alcohol use leads to alcoholic liver fibrosis. Today, a sufficient number of scientific studies are focused on the pathometabolic mechanisms of liver fibrosis development and formation in animal models. The purpose of our study was to investigate structural changes and liver stiffness, biochemical markers of fibrosis in rats with chronic alcoholic liver injury (CALI) modeling and to evaluate the changes of these parame­ters with different types of treatment. Materials and methods. Eighty-nine rats were divided into experimental groups depending on the duration of alcohol ex
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5

Abinaya, M., R. Gayathri, A. Ramya Devi, and S. Mohan. "Development of Metadoxine Lipid Microspheres for Alcohol intoxication." Research Journal of Pharmacy and Technology 13, no. 1 (2019): 69. http://dx.doi.org/10.5958/0974-360x.2020.00012.8.

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6

Di Miceli, Mathieu, and Benjamin Gronier. "Pharmacology, Systematic Review and Recent Clinical Trials of Metadoxine." Reviews on Recent Clinical Trials 13, no. 2 (2018): 114–25. http://dx.doi.org/10.2174/1574887113666180227100217.

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7

Martínez, MCLR Díaz, A. Díaz Martínez, V. Villamil Salcedo, and C. Cruz Fuentes. "Efficacy of Metadoxine in the Management of Acute Alcohol Intoxication." Journal of International Medical Research 30, no. 1 (2002): 44–51. http://dx.doi.org/10.1177/147323000203000107.

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8

Pingale, Prashant L. "FORMULATION, CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF METADOXINE TABLETS PREPARED BY VARIOUS GRANULATION METHODS." Journal of Medical pharmaceutical and allied sciences 10, no. 2 (2021): 2712–19. http://dx.doi.org/10.22270/jmpas.v10i2.1066.

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Pharmaceutical tablets are robust, flat, or biconvex dishes, according to the Indian Pharmacopoeia. Depending on a range of medicinal substances, they vary in shape and differ greatly in size and weight. In the era of increasing health awareness and strict standards set by regulatory authorities such as the US FDA, WHO, and globalization, it has become mandatory for the producer to launch a product cost-effectively. In the tablet dosage form, two classes of drugs are administered orally. Narrow extensions of the parietal peritoneum that suspend the diaphragm's liver are the right and left coro
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9

Minaiyan, Mohsen, and Parvin Mazraati. "Hepatoprotective Effect of Metadoxine on Acetaminophen-induced Liver Toxicity in Mice." Advanced Biomedical Research 7, no. 1 (2018): 67. http://dx.doi.org/10.4103/abr.abr_142_17.

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10

Jinghua, Du, Wen Zhao, Yu Lu, et al. "FRI-307-Metadoxine prevents diet-induced non-alcoholic steatohepatitis in mice." Journal of Hepatology 70, no. 1 (2019): e530-e531. http://dx.doi.org/10.1016/s0618-8278(19)31050-3.

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11

FORNAI, FRANCESCO, MARIA GRAZIA ALESSANDRI‘, UBALDO BONUCCELLI, VERA SCALORI, and GIOVANNI U. CORSINI. "Effect of metadoxine on striatal dopamine levels in C57 Black mice." Journal of Pharmacy and Pharmacology 45, no. 5 (1993): 476–78. http://dx.doi.org/10.1111/j.2042-7158.1993.tb05579.x.

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12

LÜ, Yuan, Zi-sheng KANG, Yan LIU, Tian-yun LI, and Yong-hong XIAO. "Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers." Chinese Medical Journal 120, no. 2 (2007): 166–68. http://dx.doi.org/10.1097/00029330-200701020-00021.

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13

Shpilenya, Leonid S., Alexander P. Muzychenko, Giovanni Gasbarrini, and Giovanni Addolorato. "Metadoxine in Acute Alcohol Intoxication: A Double-Blind, Randomized, Placebo-Controlled Study." Alcoholism: Clinical and Experimental Research 26, no. 3 (2002): 340–46. http://dx.doi.org/10.1111/j.1530-0277.2002.tb02543.x.

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14

Ansari, Zaid, Mays Almohammedawi, Ali Alshati, Shehroz Aslam, Dimas Kosa, and Toufic Kachaamy. "S0965 Role of Metadoxine in Alcoholic Fatty Liver Disease and Alcoholic Hepatitis." American Journal of Gastroenterology 115, no. 1 (2020): S493. http://dx.doi.org/10.14309/01.ajg.0000705908.32497.e1.

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15

Li, Huilu. "Clinical Effect Analysis of Metadoxine in the Treatment of Acute Severe Alcoholism." International Journal of Clinical and Experimental Medicine Research 8, no. 2 (2024): 263–66. http://dx.doi.org/10.26855/ijcemr.2024.04.013.

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16

Golovenko, M. Ya, O. V. Karpova, and I. Yu Borisyuk. "Metadoxine regulation of elimination of ethanol and its metabolites from the rat’s body." Klìnìčna farmacìâ 20, no. 3 (2016): 24–28. http://dx.doi.org/10.24959/cphj.16.1382.

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17

Manor, I., R. Ben-Hayun, J. Aharon, et al. "S.26.03 Metadoxine: a novel non-stimulant extended-release drug for treating ADHD." European Neuropsychopharmacology 22 (October 2012): S144. http://dx.doi.org/10.1016/s0924-977x(12)70195-5.

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18

Addolorato, G., R. Masciana, C. Ancona, et al. "13 P Metadoxine in acute alcohol intoxication: A double blind randomized placebo controlled study." Digestive and Liver Disease 34 (June 2002): A52. http://dx.doi.org/10.1016/s1590-8658(02)90199-4.

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19

Shenoy, Kotacherry T., Leena K. Balakumaran, Philip Mathew, et al. "Metadoxine Versus Placebo for the Treatment of Non-alcoholic Steatohepatitis: A Randomized Controlled Trial." Journal of Clinical and Experimental Hepatology 4, no. 2 (2014): 94–100. http://dx.doi.org/10.1016/j.jceh.2014.03.041.

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20

Manor, Iris, Jeffrey H. Newcorn, Stephen V. Faraone, and Lenard A. Adler. "Efficacy of Metadoxine Extended Release in Patients With Predominantly Inattentive Subtype Attention-Deficit/Hyperactivity Disorder." Postgraduate Medicine 125, no. 4 (2013): 181–90. http://dx.doi.org/10.3810/pgm.2013.07.2689.

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21

Tijera, Fátima Higuera-de la. "Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis." World Journal of Gastroenterology 21, no. 16 (2015): 4975. http://dx.doi.org/10.3748/wjg.v21.i16.4975.

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22

Tijera, Fátima Higuera-de la, Alfredo I. Servín-Caamaño, Javier Cruz-Herrera, et al. "Treatment with Metadoxine and its impact on early mortality in patients with severe alcoholic hepatitis." Annals of Hepatology 13, no. 3 (2014): 343–52. http://dx.doi.org/10.1016/s1665-2681(19)30863-4.

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23

Fehér, János, László Váli, Anna Blázovics, and Gabriella Lengyel. "The beneficial effect of metadoxine (pyridoxine-pyrrolidone-carboxylate) in the treatment of fatty liver diseases." Clinical and Experimental Medical Journal 3, no. 1 (2009): 65–79. http://dx.doi.org/10.1556/cemed.3.2009.1.6.

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24

Kaul, Neeraj, Himani Agrawal, Bharat Patil, Abhijit Kakad, and S. R. Dhaneshwar. "Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form." Il Farmaco 60, no. 4 (2005): 351–60. http://dx.doi.org/10.1016/j.farmac.2005.01.001.

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25

Manor, Iris, Jonathan Rubin, Yaron Daniely, and Lenard A. Adler. "Attention Benefits after a Single Dose of Metadoxine Extended Release in Adults with Predominantly Inattentive ADHD." Postgraduate Medicine 126, no. 5 (2014): 7–16. http://dx.doi.org/10.3810/pgm.2014.09.2795.

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26

Higuera-de la Tijera, M. F., A. I. Servín-Caamaño, A. Serralde- Zuñ iga, J. M. Abdo-Francis, J. Cruz-Herrera, and J. L. Pérez-Herna'ndez. "533 METADOXINE ADDED TO STEROID THERAPY IMPROVES SIX-MONTH SURVIVAL IN PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS." Journal of Hepatology 58 (April 2013): S218. http://dx.doi.org/10.1016/s0168-8278(13)60535-8.

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27

Lee, Dae Young, Hee Eun Kang, Sang Geon Kim, and Myung Gull Lee. "Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats." Archives of Pharmacal Research 33, no. 7 (2010): 1005–8. http://dx.doi.org/10.1007/s12272-010-0705-4.

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28

Gutiérrez-Ruiz, M. C., L. Bucio, A. Correa, et al. "Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture." Pharmacological Research 44, no. 5 (2001): 431–36. http://dx.doi.org/10.1006/phrs.2001.0883.

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29

Ben-Sheetrit, Joseph, Mika Zurawel, Abraham Weizman, and Iris Manor. "Symptoms Versus Impairment in Adults With ADHD: Intercorrelations of the BRIEF-A, CAARS, and TOVA." Journal of Attention Disorders 23, no. 13 (2016): 1557–66. http://dx.doi.org/10.1177/1087054716682334.

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Objective: The aim of this study is to explore the connections within and between three measures of adult ADHD: the Behavior Rating Inventory of Executive Function–Adult Version (BRIEF-A)–Self-Report, Conners’ Adult ADHD Rating Scale–Investigator-Rated (CAARS-Inv), and Test of Variables of Attention (TOVA). Method: Data of 89 adults with ADHD (ages = 18-54, 46% females) who were assessed using these measures during pretreatment visits of a randomized study of metadoxine XR were analyzed. Results: The CAARS-Inv and TOVA did not correlate. The BRIEF-A correlated extensively with both the CAARS-I
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30

Ben-Sheetrit, Joseph, Miriam Peskin, Jeffrey H. Newcorn, et al. "Characterizing the Placebo Response in Adults With ADHD." Journal of Attention Disorders 24, no. 3 (2018): 425–33. http://dx.doi.org/10.1177/1087054718780328.

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Objective: Several ADHD pharmacological trials reported high placebo response (PR) rates. This study aims to characterize the PR in adult ADHD. Method: A retrospective cohort analysis of the placebo arm (140 adults with ADHD, 18-55 yrs, M:F 46.4%-53.6%) of a 6-week randomized, multicenter, double-blind metadoxine study, using Conners’ Adult ADHD Rating Scale (CAARS) and the Adult ADHD Self-Report Scale (ASRS), was conducted. Results: Pre–post changes in placebo-treated adults were significant for both the CAARS and ASRS, F(2.9, 404.5) = 61.2, p < .00001, F(2.8, 383.0) = 43.1, p < .00001,
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31

Kasper, Philipp, and Münevver Demir. "Alkoholische Hepatitis – Aktuelle und zukünftige Behandlungskonzepte." DMW - Deutsche Medizinische Wochenschrift 148, no. 17 (2023): 1095–101. http://dx.doi.org/10.1055/a-1941-7187.

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Was ist neu? Aktuelle Therapie. Die Einhaltung einer strikten Alkoholabstinenz, eine Optimierung des Ernährungsstatus, die Vermeidung von Infektionen sowie die Gabe von Kortikosteroiden sind derzeit die Hauptpfeiler der Behandlung von Patienten mit Alkoholischer Hepatitis (AH). Neue Therapieansätze. Infolge eines verbesserten Verständnisses der zugrundeliegenden Pathomechanismen der AH werden derzeit eine Vielzahl neuer, innovativer Therapiemethoden in klinischen Studien untersucht, welche das Potenzial aufweisen, das Outcome der Betroffenen zu verbessern und die hohe Kurzzeitmortalität dieser
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32

Kaul, N., H. Agrawal, B. Patil, A. Kakad, and S. R. Dhaneshwar. "Stability-Indicating HPLC Method for the Determination of Metadoxine as Bulk Drug and in Pharmaceutical Dosage Form." Chromatographia 60, no. 9-10 (2004): 501–10. http://dx.doi.org/10.1365/s10337-004-0429-z.

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33

Caballería, Joan, Albert Parés, Concepció Brú, et al. "Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial." Journal of Hepatology 28, no. 1 (1998): 54–60. http://dx.doi.org/10.1016/s0168-8278(98)80202-x.

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34

Muriel, Pablo, and Rogelio Deheza. "Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine." Liver International 23, no. 4 (2003): 262–68. http://dx.doi.org/10.1034/j.1600-0676.2003.00837.x.

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35

Leggio, Lorenzo, George A. Kenna, Anna Ferrulli, et al. "Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease." Human Psychopharmacology: Clinical and Experimental 26, no. 8 (2011): 554–59. http://dx.doi.org/10.1002/hup.1244.

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36

Sharma, H., S. C. Chadha, and R. Gupta. "To Study the Role of Metadoxine on Liver Function Tests in the Management of Chronic Hepatitis B Infection." International Journal of Contemporary Medicine 5, no. 1 (2017): 42. http://dx.doi.org/10.5958/2321-1032.2017.00009.2.

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37

Shayakhmetova, G. M., O. V. Karpova, A. K. Voronina, and N. Y. Golovenko. "State of biochemical system of white rat’s blood in conditions of alcoholic hepatic injury and preventive action metadoxine." Ukraïns’kij bìofarmacevtičnij žurnal, no. 2(43) (April 12, 2016): 22–26. http://dx.doi.org/10.24959/ubphj.16.18.

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38

Park, Sang Hoon, Jong Eun Yeon, Kwan Soo Byun, and Chang Hong Lee. "An Efficacy Evaluation of the Oral Administration Metadoxine in Korean Alcoholic Liver Patients: a Randomized, Placebo-Controlled Trial." Journal of Korean Society for Clinical Pharmacology and Therapeutics 6, no. 2 (1998): 183. http://dx.doi.org/10.12793/jkscpt.1998.6.2.183.

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39

Stefanini, Giuseppe Francesco, Giovanni Addolorato, Fabio Caputo, Mauro Bernardi, and Giovanni Gasbarrini. "Treatment of alcoholic fatty liver: is the metabolic effect of metadoxine the only reason for improved liver function?" Journal of Hepatology 30, no. 4 (1999): 739. http://dx.doi.org/10.1016/s0168-8278(99)80209-8.

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40

Khomyn, Halyna, та Liliia Babinets. "Effectiveness of Differentiated Hepatotrophic Therapy in Complex Management of Patients with Comorbidity of Chronic Pancreatitis and Chronic Viral Hepatitis С". Family medicine. European practices, № 4 (29 грудня 2022): 52–58. http://dx.doi.org/10.30841/2786-720x.4.2022.274662.

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An important problem of the combined course of chronic pancreatitis (CP) and chronic hepatitis C virus (HCV) is the study of the effects of chronic HCV, even after the treatment, in particular for the condition of the pancreas and liver in patients with CP. Often hepatotrophic therapy is used for this purpose, which should be differentiated depending on the needs of patients with comorbidity of CP and chronic HCV. The objective: to analyze the functional and structural condition of the pancreas and liver in patients with CP after the chronic HCV treatment by the proposed complex treatment with
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41

Khomyn, Halyna, та Liliia Babinets. "Effectiveness of Differentiated Hepatotrophic Therapy in Complex Management of Patients with Comorbidity of Chronic Pancreatitis and Chronic Viral Hepatitis С". Family Medicine. European Practices, № 4 (29 грудня 2022): 52–58. https://doi.org/10.30841/2786-720X.4.2022.274662.

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An important problem of the combined course of chronic pancreatitis (CP) and chronic hepatitis C virus (HCV) is the study of the effects of chronic HCV, even after the treatment, in particular for the condition of the pancreas and liver in patients with CP. Often hepatotrophic therapy is used for this purpose, which should be differentiated depending on the needs of patients with comorbidity of CP and chronic HCV. <strong>The objective:</strong>&nbsp;to analyze the functional and structural condition of the pancreas and liver in patients with CP after the chronic HCV treatment by the proposed
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42

Mayuri K and Sunitha S. "Alcoholic Hepatitis – A Fatal Disease." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 1770–79. http://dx.doi.org/10.26452/ijrps.v12i3.4780.

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Liver is the vital organ that metabolizes and excretes nutrients. Failure of the liver leads to death in cases. The complication which causes liver failure is excessive alcohol consumption. Liver metabolizes ethanol and it faces the highest degree of injury by uncontrolled drinking. Alcohol use produces a broad spectrum of diseases; hepatosteatosis, Alcoholic hepatitis, fibrosis &amp; cirrhosis. Pathogenesis of Alcohol related Liver Diseases (ALD) is explained by hepatic lipogenesis, deceleration of hepatic lipid breakdown, defective hepatic lipid export, macrophage induced alcoholic hepatitis
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43

Higuera-de la Tijera, F., A. I. Servin-Caamaño, A. E. Serralde-Zuñiga, et al. "P302 METADOXINE SIGNIFICANTLY IMPROVES SURVIVAL IN ABIC CLASS B PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS WHEN ADDED TO PENTOXIFYLLINE OR PREDNISONE." Journal of Hepatology 60, no. 1 (2014): S166. http://dx.doi.org/10.1016/s0168-8278(14)60464-5.

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44

Muriel, P., and R. Deheza. "Metadoxine partially prevents fibrosis and completely preserves glycogen stores in prolonged biliary obstruction in the rat: A comparison with colchicine." Journal of Hepatology 38 (April 2003): 79. http://dx.doi.org/10.1016/s0168-8278(03)80326-4.

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45

Ki, Sung Hwan, Jae Hoon Choi, Choon Won Kim, and Sang Geon Kim. "Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity." Chemico-Biological Interactions 169, no. 2 (2007): 80–90. http://dx.doi.org/10.1016/j.cbi.2007.05.008.

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46

Sridharan, Kannan, Gowri Sivaramakrishnan, Reginald Paul Sequeira, and Abdelaziz Elamin. "Pharmacological interventions for non-alcoholic fatty liver disease: a systematic review and network meta-analysis." Postgraduate Medical Journal 94, no. 1116 (2018): 556–65. http://dx.doi.org/10.1136/postgradmedj-2018-135967.

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AimSeveral drugs have been used for treating non-alcoholic fatty liver disease (NAFLD). The present study is a network meta-analysis of such drugs.Design, setting and patientsRandomised clinical trials comparing drug interventions in patients with NAFLD were analysed. OR and weighted mean difference (95 % CI) were the effect estimates for categorical and numerical outcomes, respectively. Random-effects model was used to generate pooled estimates. Surface under the cumulative ranking curve was used to rank the treatments.Main outcome measuresProportion of responders was the primary outcome meas
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47

Giustino, Arcangela, Annamaria Natola, Giovanni Savoia, Maria Antonietta De Salvia, and Carmine Finelli. "Reduced Pharmacological Intervention of Prehospital Services for Acute Alcohol Intoxication during the COVID-19 Pandemic in A Large District of Southern Italy." Journal of Clinical Medicine 13, no. 11 (2024): 3057. http://dx.doi.org/10.3390/jcm13113057.

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Background Stress during a pandemic increases the risk of alcohol consumption, which may require pharmacological management. Methods An observational single-center retrospective study was conducted from 1 January 2018 to 31 December 2021, and divided into 2-year periods (2018–2019 and 2020–2021). This study focused on calls to one of the emergency departments (EDs) of seven hospitals in the Bari (Italy) metropolitan area for patients requiring emergency services (ESs) who were either admitted or not admitted, due to their refusal. Results A 30% reduction in emergency calls for alcohol-related
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48

Zhao, Ting, Limin Zuo, Huiyi Liu, and Guangzhi Shan. "An eco-friendly and stable capillary zone electrophoresis method for the analysis of metadoxine based on accurate molar response factor obtained from crystal." Sustainable Chemistry and Pharmacy 43 (February 2025): 101888. https://doi.org/10.1016/j.scp.2024.101888.

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49

Yang, Yoon Mee, Hyun Eun Kim, Sung Hwan Ki, and Sang Geon Kim. "Metadoxine, an ion-pair of pyridoxine and l-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway." Archives of Biochemistry and Biophysics 488, no. 2 (2009): 91–99. http://dx.doi.org/10.1016/j.abb.2009.07.007.

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50

Manor, Iris, Rachel Ben-Hayun, Judith Aharon-Peretz, et al. "A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy, Safety, and Tolerability of Extended-Release Metadoxine in Adults With Attention-Deficit/Hyperactivity Disorder." Journal of Clinical Psychiatry 73, no. 12 (2012): 1517–23. http://dx.doi.org/10.4088/jcp.12m07767.

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