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Journal articles on the topic 'Metal Biguanides'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

T., R. BERA, and KONAR J. "Thermal Behaviour of Metal Biguanides and their Iodine Adducts." Journal of Indian Chemical Society Vol. 74, Jul 1997 (1997): 528–31. https://doi.org/10.5281/zenodo.5901431.

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Department of Chemistry, Indian Institute of Technology, Kharagpur-721 302 <em>Manuscript received 17 July 1995, revised 3 June 1996, accepted 19 June 1996</em> 1 : 1 charge transfer adducts of Cu<sup>II</sup> and Ni<sup>II</sup> biguanides with I<sub>2</sub> have been prepared. Thermal characteristics of metal biguanides, substituted metal biguanides and their charge transfer adducts have been studied. The general features of the thermoanalytical traces are almost same except in case of iodine adducts. The evolution of iodine from the iodine adduct at appreciably lower temperature than the us

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2

Rani, Bina. "Coordination Chemistry of Cobalt Biguanide Complex: Ligand Interaction and Metal Complex Stability." International Journal for Research in Applied Science and Engineering Technology 13, no. 5 (2025): 7390–93. https://doi.org/10.22214/ijraset.2025.71822.

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Biguanides are versatile organic compounds known for their broad applications in medicinal chemistry, coordination chemistry, and catalysis. Biguanide, C₂N₅H₇ is a nitrogen donor bidentate ligand. Structurally, they contain two linked guanidine moieties, which enable strong chelation with metal ions, forming stable complexes. The ability of biguanides to interact with transition metals has led to the development of metal-biguanide complexes with remarkable biological and catalytic properties. These complexes exhibit diverse coordination modes influenced by steric and electronic factors, result

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3

Singh, Namrata, PratimaKatiyar PratimaKatiyar, Kalpana Kalpana, and Priyanka Sonker. "Biguanide scaffold: Chemistry, Stability and Pharmacophoric Features For Drug Discovery." Journal of Neonatal Surgery 14, no. 9S (2025): 126–35. https://doi.org/10.52783/jns.v14.2637.

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Around the world, biguanides like metformin are often used to treat type-2 diabetes. Biguanides were created as a result of the discovery of guanidine and similar substances in the French lilac plant (Galegaofficinalis L.). Using the common medication metformin, the produced compounds were tested for their anti-diabetic properties. Drugs' mechanisms of action are determined by their electrical and structural makeup. Pharmacophoric feature detection is aided by accurate structural depiction of medications. Although biguanide derivatives are a significant class of pharmaceuticals, little is know

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4

Grytsai, Oleksandr, Cyril Ronco, and Rachid Benhida. "Synthetic accesses to biguanide compounds." Beilstein Journal of Organic Chemistry 17 (May 5, 2021): 1001–40. http://dx.doi.org/10.3762/bjoc.17.82.

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Biguanide is a unique chemical function, which has attracted much attention a century ago and is showing resurgent interest in recent years after a long period of dormancy. This class of compounds has found broad applications such as reaction catalysts, organic strong bases, ligands for metal complexation, or versatile starting materials in organic synthesis for the preparation of nitrogen-containing heterocycles. Moreover, biguanides demonstrate a wide range of biological activities and some representatives are worldwide known such as metformin, the first-line treatment against type II diabet

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5

Prachi, Pahade, and Katolkar Parimal. "A SYSTEMATIC REVIEW ON METAL COMPLEXES OF SOME MEDICINAL COMPOUNDS." International Journal of Applied and Advanced Scientific Research (IJAASR) 5, no. 2 (2020): 9–21. https://doi.org/10.5281/zenodo.4013945.

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Metal ions plays an important role in biological processes and also in metal homeostasis. Metal imbalance in body may cause several diseases. To overcome such condition various derivatives of drugs are complexed with different metals like Cu, Zn, Mn, Ni, Co, Pt, Cd, Fe, Hg etc. Drugs like captopril, acyclovir, Biguanides, Theophylline, Chloriquine, triazole, Nicotinic acid and their derivatives hold medicinal properties such as   ant neurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. This article shows the synthesis of some nove

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6

SYAMAL, A. "ChemInform Abstract: Structure of Various Biguanides and Metal Complexes of Biguanides." ChemInform 26, no. 48 (2010): no. http://dx.doi.org/10.1002/chin.199548291.

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7

Rusanov, Daniil A., Jiaying Zou, and Maria V. Babak. "Biological Properties of Transition Metal Complexes with Metformin and Its Analogues." Pharmaceuticals 15, no. 4 (2022): 453. http://dx.doi.org/10.3390/ph15040453.

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Metformin is a widely prescribed medication for the treatment and management of type 2 diabetes. It belongs to a class of biguanides, which are characterized by a wide range of diverse biological properties, including anticancer, antimicrobial, antimalarial, cardioprotective and other activities. It is known that biguanides serve as excellent N-donor bidentate ligands and readily form complexes with virtually all transition metals. Recent evidence suggests that the mechanism of action of metformin and its analogues is linked to their metal-binding properties. These findings prompted us to summ

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8

François, AÏDOTE, KUEVI Urbain Amah, KPOTIN Assongba Gaston, and ATOHON Guy Sylvain. "DFT Study of Coordination of N-Monochlorosubstituation Derivatives of Biguanide." International Research Journal of Pure and Applied Chemistry 25, no. 6 (2024): 98–110. https://doi.org/10.9734/irjpac/2024/v25i6888.

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Biguanides [HN=C(NR1R2)-NH-C(NR3R4)=NH] constitute an important family of molecules used as drugs in the treatment of diabetes. It is known that some transition metal complexes with given organic compounds deeply increase both therapeutic actions of the metal and the organic compound. The chlorine atom, a preferred substitute in pharmacy, improves the effectiveness of drugs and reduces their side effects. The mesmeric +M effect of the chlorine atom would make it possible to enhance the nucleophilic character of any N-chlorosubstituted nitrogen. In this work a theoretical study of coordination

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9

Olar, Rodica, Mihaela Badea, and Mariana Carmen Chifiriuc. "Metal Complexes—A Promising Approach to Target Biofilm Associated Infections." Molecules 27, no. 3 (2022): 758. http://dx.doi.org/10.3390/molecules27030758.

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infecti

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10

Guha, Supriya, and Debabrata Banerjea. "Kinetics and mechanism of dissociation of copper(II) complexes of biguanide and someN 1-substituted biguanides in aqueous acetate buffer media." Transition Metal Chemistry 16, no. 4 (1991): 441–44. http://dx.doi.org/10.1007/bf01129460.

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11

Villamizar-Delgado, Stephanny, Laura M. Porras-Osorio, Octavio Piñeros, et al. "Biguanide–transition metals complexes as potential drug for hyperglycemia treatment." RSC Advances 10, no. 38 (2020): 22856–63. http://dx.doi.org/10.1039/d0ra04059b.

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Coordination compounds of Cu(ii), Ni(ii), Co(ii), and Zn(ii) with a type of biguanide were obtained and structurally characterized. The new metal-drugs present biological applications as potential drugs for diabetes and metabolic syndrome.

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12

Sweeney, Deacon, Michael L. Raymer, and Thomas D. Lockwood. "Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents." Biochemical Pharmacology 66, no. 4 (2003): 663–77. http://dx.doi.org/10.1016/s0006-2952(03)00338-1.

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13

R.K.RAY and B. KAUFFMAN GEORGE. "Chromatographic Studies of Metal Complexes. Part-lll. Adsorption, Dissociation, and Intermediate Complex Formation of some Square-planar Biguanide Complexes of Copper(II), Nickel(II) and Palladium(II) on Silica Gel." Journal of Indian Chemical Society Vol. 68, May 1991 (1991): 291–93. https://doi.org/10.5281/zenodo.6155204.

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Department of Chemistry, Rama Krishna Mission Vivekananda Centenary College. Rahara-743 186 Department of Chemistry, California State University, Fresno, California 93740, U.S.A. <em>Manuscript received 18 September 1989, revised 19 March 1991 accepted 23 April 1991</em> Chromatographic Studies of Metal Complexes. Part-lll. Adsorption, Dissociation, and Intermediate Complex Formation of some Square-planar Biguanide Complexes of Copper(II), Nickel(II) and Palladium(II) on Silica Gel.

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14

Hamed, Othman, Majdi Qaisi, Ibrahim Abushqair, et al. "Cellulose powder functionalized with phenyl biguanide: Synthesis, cross-linking, metal adsorption, and molecular docking." BioResources 16, no. 4 (2021): 7263–82. http://dx.doi.org/10.15376/biores.16.4.7263-7282.

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A cellulose polymer functionalized with an amine chelating agent was designed and synthesized in a three-step process that involved oxidizing cellulose powder into dialdehyde cellulose, reacting cellulose dialdehyde with phenyl biguanide to create an imine linkage between the two reactants, and reducing the imine linkage to an amine. The cellulose amine polymer was cross-linked with glycerol digycidyl ether and evaluated as an adsorbent of toxic metal ions from wastewater. The adsorption efficiency of the cross-linked cellulose amine polymer toward Pb(II) and Cu(II) was evaluated as a function

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15

Kumar, Manoj, Pallvi, Hardeep Singh Tuli, and Rajshree Khare. "Synthesis, Characterization and Biological Studies of Novel Schiff Base viz. Bis-1,1'-(pyridine-2,6-diyldieth-1-yl-1-ylidene) biguanidine and Their Transition Metal Complexes." Asian Journal of Chemistry 31, no. 4 (2019): 799–804. http://dx.doi.org/10.14233/ajchem.2019.21732.

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Novel Schiff base and its two transition metal complexes derived from the condensation reaction of 2,6-diacetylpyridine with biguanide, characterized by 1H NMR, IR and elemental analysis. The ligand and its cobalt(II) and nickel(II) complexes showed potent DNA photo-cleavage activity. Antimicrobial activity of this Schiff base and its cobalt(II) and nickel(II) complexes against bacteria and fungi viz. S. aureus, K. pneumoniaae and A. niger, Trichophyton rubrum, respectively was evaluated in terms of zone of inhibition.

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16

Das, Bankim C., I. Dey, G. Biswas, R. Banerjee, Y. Iitaka, and A. Banerjee. "Crystal and molecular structure of a new biguanide metal complex, [Cu(AMNH)2]Cl2." Journal of Crystallographic and Spectroscopic Research 23, no. 6 (1993): 509–12. http://dx.doi.org/10.1007/bf01182528.

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17

Long, Wei, Rujun Zhou, Zixuan Du, et al. "A Dual-Band Carbon Dioxide Sensor Based on Metal–TiO2–Metal Metasurface Covered by Functional Material." Photonics 9, no. 11 (2022): 855. http://dx.doi.org/10.3390/photonics9110855.

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Highly sensitive and integrated optical multi-band CO2 sensors are significant at the shortwave infrared (SWIR) region and still lack research. A compact CO2 sensor composed of a Au-disk/TiO2-cylinder/Au-film metasurface coated by polyhexamethylene biguanide (PHMB) film, functioning at multi-band resonances as well as having high sensitivity to gas concentrations, is presented. It can be employed as a dual-band narrowband absorber, producing two strongly resonant modes at the SWIR region under a reflection-type framework of linearly polarized incidence. Moreover, the metasurface sensor possess

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18

Armi, Armi, Dewi Fitriani, Mila Sartika, and Yana Setiawan. "effectiveness of wound caring technique with polyhexamethylene biguanide and dialkyl carbamoyl chloride to healing process duration of diabetic foot ulcer patient." Jurnal Keperawatan Padjadjaran 11, no. 1 (2023): 18–24. http://dx.doi.org/10.24198/jkp.v11i1.2152.

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Background: Antimicrobial dressing on moist-based wound care is a successful wound care technique, especially for diabetes mellitus wounds. The moisture on wound can be made by closed wound care to reach a standard moisture in various wounds. The antimicrobial dressing type that can increase the wound healing is Polyhexamethylene biguanide (PHMB) and Dialkyl carbamoyl chloride (DACC). Polyhexamethylene biguanide can accelerate the tissue granulation and reduce the risk of infection. Dialkyl carbamoyl chloride is a part of moist wound healing with strong hydrophobic threat so the bacteria will

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19

Mihalache, Mădălina, Ticuţa Negreanu-Pîrjol, Florea Dumitraşcu, Constantin Drăghici, and Mirela Călinescu. "Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine." Journal of the Serbian Chemical Society 83, no. 3 (2018): 271–84. http://dx.doi.org/10.2298/jsc170911119m.

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Six new coordination compounds of Ni(II), Pd(II) and Cr(III) with chlorhexidine, 1,1?-hexamethylenebis[5-(4-chlorophenyl)biguanide], were prepared, characterized and examined for their potential as antimicrobial agents, as well as for their antioxidant activity. The metal complexes correspond to the formulas: [Ni(CHX)]Cl2?2H2O, [Ni(CHX)]Br2?2H2O, [Ni(CHX)](CH3COO)2?C2H5OH, [Pd(CHX)][PdCl4]?2H2O, [Pd(CHX)](CH3COO)2 and [Cr(CHX)Cl2](CH3COO), where CHX = chlorhexidine. Investigations on the in vitro antimicrobial activity of the complexes indicated that all have high activity against the tested b

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20

Kawaguchi, Hiroshi, Mizuki Matsuki, Tomoharu Ama, and Takaji Yasui. "Metal Complexes of Amino Acids. XV. Racemization and Deuteration of Bis(biguanide)sarcosinatocobalt(III) Complex." Bulletin of the Chemical Society of Japan 59, no. 1 (1986): 31–38. http://dx.doi.org/10.1246/bcsj.59.31.

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21

Tannistha, Roy Barman, and N. Mukherjee G. "Mixed-ligand complex formation equilibria of CuII with histidine and biguanide." Journal of Indian Chemical Society Vol. 87, Aug 2010 (2010): 899–907. https://doi.org/10.5281/zenodo.5799148.

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Department of Chemistry, University College of Science, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata-700 009, India <em>E-mail:</em> mukherg@rediffmail.com Fax : 91-033-2351-9755/2241-3222 <em>Manuscript received 11 January 2010, revised 24 February 2010, accepted 25 February 2010</em> Combined spectrophotometric and computer-based pH-metric investigations on the mixed-ligand complex formation equilibria or Cu<sup>II</sup> with histidine [(C<sub>3</sub>H<sub>3</sub>N<sub>2</sub>)CH<sub>2</sub>CH(NH<sub>2</sub>)COOH, hisH\( \pm\)] and biguanide [NH<sub>2</sub>C-

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22

Calinescu, Mirela, Ovidiu Oprea, Catalina Stoica, Mihai Nita-Lazar, and Madalina Mihalache. "Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) � Synthesis, Spectral Characterization and Biological Activity." Revista de Chimie 71, no. 4 (2020): 336–46. http://dx.doi.org/10.37358/rc.20.4.8073.

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Four coordination compounds of Pd(II), Pt(II) and Pt(IV) with usnic acid (H3AU) and 1-(o-tolyl)biguanide (TB) as ligands have been synthesized in view of their potential as antimicrobial, antifungal and antitumor agents. The metal complexes have been characterized by elemental and thermogravimetrical analyses, infrared and electronic spectra. Based on these studies, the following formulas have been proposed for the complexes: [Pd(TB)(H3AU)]PdCl4 (C1), [Pd(TB)(H2AU)] CH3COO (C2), [Pt(TB)(H2AU)Cl2]Cl (C3) and [Pt(TB)(H2AU)]Cl (C4), where H2AU is deprotonated usnic acid. The in vitro biological

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23

Dasgupta, Subrata, Amitava Das, and Rupendranath Banerjee. "Decomposition kinetics ofbis(biguanide)silver(III) cation in acid perchlorate media." Transition Metal Chemistry 14, no. 1 (1989): 19–21. http://dx.doi.org/10.1007/bf01129752.

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24

S., P. Ghosh, K. Prasad R., and Bina Rani (Mrs.). "On mononitrosylcobalt(biguanidinium) complexes." Journal of Indian Chemical Society Vol. 80, Oct 2003 (2003): 912–13. https://doi.org/10.5281/zenodo.5839346.

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Department of Chemistry, Science College, Patna University, Patna-800 005, India Department of Chemistry, M. M. College, Patna University, Patna-800 001, India <em>Manuscript received 20 November 2002, accepted 13 June 2003</em> A new six-coordianted mononitrosylcobalt(III)biguanide complex, [Co(BigH<sup>+</sup>)<sub>2</sub>(NO<sup>-</sup>)H<sub>2</sub>O]<sup>2+</sup>SO<sub>4</sub>.1.5H<sub>2</sub>O (where, BigH+ = C<sub>2</sub>N<sub>5</sub>H<sub>7</sub>), has been prepared by passing pure NO gas through the methanolic suspension of the freshly prepared bis(higuanidinium)cohlat(II) sulphate, [

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25

Niu, Bing, Wan Huai, Zhirui Deng, and Qin Chen. "Fungicidal, Corrosive, and Mutational Effects of Polyhexamethylene Biguanide Combined with 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/4357031.

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Background. The disinfectants polyhexamethylene biguanide (PHMB) and 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH) each have limitations. So far, their combined usage has not been examined. In this study, the fungicidal activity of combined disinfectant using PHMB and BCDMH, named PB, against Candida albicans was evaluated. Methods. Suspension quantitative fungicidal test and viable fungi count were used to test fungicidal effects against C. albicans. Coupon corrosion testing was used to evaluate disinfectants’ corrosive effects on stainless steel, copper, and aluminum. The mous

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26

Nuryono, Nuryono, Nur Mutia Rosiati, Abraham L. Rettob, Suyanta Suyanta, and Yateman Arryanto. "Coating of 2-Aminobenzimidiazole and 1-(o-Tolyl)biguanide Functionalized Silicas on Iron Sand Magnetic Material for Sorption of [AuCl₄]^–." Indonesian Journal of Chemistry 19, no. 2 (2019): 395. http://dx.doi.org/10.22146/ijc.34653.

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Two novel materials of 2-aminobenzimidiazole (AB) and 1-(o-tolyl)biguanide (TB) modified silicas coated on the iron sand magnetic material (MM@SiO2/AB and MM@SiO2/TB) have been synthesized and were used to adsorb Au(III) from Au/Cu/Ni solution. Silica layering MM was modified with polyamino compounds via a sol-gel process using a sodium silicate solution, 3-chloropropyltrimethoxysilane (CPTS) and modifier compounds. Adsorption of Au(III) on MM@SiO2/AB and MM@SiO2/TB was investigated in a batch system by varying pH, initial concentration, contact time and the presence of other metal ions (Cu(II

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27

Gisya, Abdi, Alizadeh Abdolhamid, Zinadini Sirus, and Moradi Golshan. "Removal of dye and heavy metal ion using a novel synthetic polyethersulfone nanofiltration membrane modified by magnetic graphene oxide/metformin hybrid." Journal of Membrane Science 552 (February 12, 2018): 326–35. https://doi.org/10.1016/j.memsci.2018.02.018.

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In this research, active groups of biguanide were grafted to the surface of graphene oxide sheets through covalent functionalization and combined with magnetic nanoparticles to produce a magnetic graphene-based composite (MMGO). Then, the fabricated MMGO hybrid was introduced into the polyethersulfone (PES) polymer through phase inversion induced by immersion precipitation method. The prepared MMGO embedded PES membranes were examined for pure water flux permeability, salt rejection, antifouling, copper removal, and dye retention capability. The effect of MMGO hybrid on the cross-sectional mor

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28

Das, Amit, and Subrata Mukhopadhyay. "Kinetics of oxidation of pyruvic acid by [ethylenebis(biguanide)]silver(III) in aqueous acidic media." Transition Metal Chemistry 29, no. 7 (2004): 797–803. http://dx.doi.org/10.1007/s11243-004-1015-9.

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Marzieh, Sadeghi, Shiri Fatemeh, Kordestani Davood, Mohammadi Pourya, and Alizadeh Abodolhamid. "SBA‑15/Metformin as a novel sorbent combined with surfactant‑assisted dispersive liquid–liquid microextraction (SA‑DLLME) for highly sensitive determination of Pb, Cd and Ni in food and environmental samples." Journal of the Iranian Chemical Society 15 (February 6, 2018): 753–68. https://doi.org/10.1007/s13738-017-1272-0.

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This paper established a new, rapid and sensitive method for the ultra-trace determination of lead, cadmium and nickel in food and environmental samples preconcentrated by dispersive solid-phase extraction (DSPE) combined with surfactant-assisted dispersive liquid–liquid microextraction (SA-DLLME) prior to graphite furnace atomic absorption spectrometry. SBA-15/Met was synthesized and used as a new efficient sorbent for the extraction of metal ions in DSPE. It was characterized by TEM and TGA techniques. After DSPE step, stripped metal elements were complexed with dithizone, and then, th

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30

Romash, Ivan. "The role of metformin hydrochloride in complex therapy of disorders of carbohydrate metabolism in patients with paranoid schizophrenia treated with atypical antipsychotics." Mental Health: Global Challenges Journal 3, no. 1 (2020): 45–51. http://dx.doi.org/10.32437/mhgcj.v3i1.93.

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Introduction. According to the literature, mortality among patients with schizophrenia is 1.5 -2 times higher than in the healthy population. One explanation for this is the complication of neuroleptic therapy, which, according to various authors, occurs in 2 to 100% of cases. Purpose. We aimed to study some indicators of carbohydrate metabolism disorders in patients with paranoid schizophrenia who have been taking neuroleptics for a long time, to correct the established changes by adding metformin hydrochloride to the standard regimen and to monitor its effectiveness. Methodology.

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Pramanik, Trishna, Asim Das, and Debabrata Banerjea. "Kinetics and mechanism of reactions of bis(biguanide)copper(II) ion with 2,2?-bipyridyl and 1,10-phenanthroline in aqueous solution." Transition Metal Chemistry 16, no. 3 (1991): 332–34. http://dx.doi.org/10.1007/bf01024076.

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Krutyakov, Yurii A., Maria T. Mukhina, Olga A. Shapoval, and Meisam Zargar. "Effect of Foliar Treatment with Aqueous Dispersions of Silver Nanoparticles on Legume-Rhizobium Symbiosis and Yield of Soybean (Glycine max L. Merr.)." Agronomy 12, no. 6 (2022): 1473. http://dx.doi.org/10.3390/agronomy12061473.

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Interest in the use of silver as a component of plant protection products and growth regulators appeared relatively recently with the development of methods for the effective stabilization of colloidal systems containing nanoparticles of this metal. In the present work, we studied the effect of foliar treatments with aqueous dispersions of silver nanoparticles stabilized by polyhexamethylene biguanide hydrochloride with an average diameter of 6 ± 1 nm and a zeta-potential of +47.4 ± 1.3 mV on legume-Rhizobium symbiosis, which largely determines the efficiency of soil nitrogen assimilation and

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33

Lockwood, Thomas D. "Biguanide is a modifiable pharmacophore for recruitment of endogenous Zn2+ to inhibit cysteinyl cathepsins: review and implications." BioMetals 32, no. 4 (2019): 575–93. http://dx.doi.org/10.1007/s10534-019-00197-1.

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34

Hayes, Joseph F., Andreas Lundin, Susanne Wicks, et al. "Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness." JAMA Psychiatry 76, no. 4 (2019): 382. http://dx.doi.org/10.1001/jamapsychiatry.2018.3907.

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35

Alekseenko, Olga V., Evgeniy Yu Kovalchuk, Alexandr V. Risev, Anastasiya M. Sergeeva, and Alexey V. Lapickiy. "Case of lactacidosis in acute kidney damage and metformin therapy." HERALD of North-Western State Medical University named after I.I. Mechnikov 13, no. 4 (2021): 85–90. http://dx.doi.org/10.17816/mechnikov81407.

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Тhe article provides a clinical observation of the development of a rare pathological condition of lactic acidosis in a patient with acute kidney injury while taking metformin and confirms the need for timely determination of blood lactate. Тhe clinical case confirms that the development of lactic acidosis in a patient with diabetes mellitus may have a mixed etiology and be associated not only with the use of metformin, but also with the presence of tissue hypoxia, exposure to an infectious process, and impaired renal function. The development of lactic acidosis is associated with

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36

Gangopadhyay, Ashis Kumar, and Gauri Sankar De. "Kinetics of substitution of aquo ligands fromcis-diaquo-bis-(biguanide) cobalt(III) and chromium(III) ions by aspartic acid in ethanol?water mixtures." Transition Metal Chemistry 14, no. 4 (1989): 241–47. http://dx.doi.org/10.1007/bf01098220.

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37

Dey, Biswajit, Somnath Ray Choudhury, Suranjana Das, et al. "A tridentate in situ generated ligand that directs the self-assembly of a transition metal complex: Synthesis and structural characterization of cis-dichloro[1-(2-aminoethyl)biguanide]copper(II) monohydrate." Polyhedron 27, no. 13 (2008): 2899–904. http://dx.doi.org/10.1016/j.poly.2008.06.026.

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38

Lorena, de Alencar Ferreira Delmondes, Clara de Lima Tenório Ana, Zenóbio Pessoa Araújo Fhelip, et al. "EFEITOS DO USO DA METFORMINA EM PACIENTES COM DIABETES TIPO 2: UMA REVISÃO DE LITERATURA." Revistaft 27, no. 124 (2023): 84. https://doi.org/10.5281/zenodo.8161984.

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<strong><em>Introdução</em></strong><em><strong>:</strong></em> O diabetes mellitus (DM) é uma doença crônica que atinge proporções epidêmicas no mundo todo. Caracteriza-se por ser uma síndrome metabólica de origem múltipla, decorrente ora da deficiência na produção de insulina, ora da resistência à ação da insulina. Quanto ao Diabetes Mellitus do tipo 2 (DM2), o mais prevalente, o início é insidioso, evoluindo com resistência à insulina e de

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Morinaga, Sho, Yasuyuki Mori, Takehiro Kawauchi, Takeshi Endo, and Yoshio Furusho. "Biguanide Hydroiodide as Efficient, Metal‐Free Catalyst for Synthesis of Cyclic Carbonates From CO₂ and Epoxides Under Mild Conditions and Its Application to Synthesis of Polymer Bearing Cyclic Carbonate Moiety." Journal of Polymer Science, May 19, 2025. https://doi.org/10.1002/pol.20250276.

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ABSTRACTNovel use of biguanides as catalysts for the efficient synthesis of five‐membered cyclic carbonates (5CCs) from CO2 and epoxides has been developed. Among biguanides and their salts, biguanide hydroiodide showed efficient catalysis for the 5CC formation under mild conditions. The catalytic system was successfully applied to the synthesis of not only monofunctional 5CCs but also multifunctional ones.

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Akinwunmi, Olubunmi Adenike. "In vitro antioxidant, 𝛼-amylase and 𝛼-glucosidase activities of methanol extracts from three Momordica species". International Journal of Phytomedicine 11, № 1 (2019). http://dx.doi.org/10.5138/09750185.2303.

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<p>Antioxidant based drug preparations are used in the prevention and management of complex diseases which include atherosclerosis, stroke, diabetes, alzheimer’s disease and cancer. Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this ailment, which may be achieved through the use of oral hypoglycemic drugs such as biguanides, insulin secretagogues, and 𝛼-amylase and glucosidase inhibitors. Although several biological activities had been reported for <em>Momordica</em> <em>foetida

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Ana, Maria Santos Cardoso; Plínio Rocha Oliveira Mateus Sousa Gonçalves ;. Daniel Oliveira Mendes Ferraz Luiza Marina da Costa Lima ;. Hailla Cristina Pereira Santos Sávio Nixon Passos Luz ;. Pedro de Carvalho Figueredo Isabela Feitosa Andrade ;. Lucas Arruda Macedo Coelho Stephanie Cassiano de Oliveira Alves ;. Thyago Layron Sampaio de Abreu André Luiz silva ;. Paulo Henrique de Oliveira Moreira Letícia Carvalho Tacão. "IMPACTOS METABÓLICOS DAS BIGUANIDAS NA TERAPIA DO DIABETES." June 7, 2024. https://doi.org/10.5281/zenodo.11519906.

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<strong>Introdução:</strong> As biguanidas, especialmente a metformina, são amplamente usadas no tratamento do diabetes mellitus tipo 2 (DM2), sendo a primeira linha de tratamento para a maioria dos pacientes. <strong>Objetivo:</strong> Este trabalho tem como objetivo geral investigar os efeitos metabólicos e cardiovasculares das biguanidas, particularmente a metformina, no tratamento do diabetes mellitus tipo 2.  <strong>Métodos:</strong> Foi realizada uma revisão bibliográfica sistemática de estudos publicados e

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Chen, Siyuan, Jingyun Xi, Yuanyuan Xu, et al. "Extracellular Matrix‐Inspired Antibacterial Fibrous Hydrogels Containing Polyhexamethylene Biguanide and Gd³⁺." Macromolecular Rapid Communications, December 4, 2024. https://doi.org/10.1002/marc.202400696.

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AbstractTraditional bulk hydrogels containing antibiotics or metal ions often fall short in effectively treating wound infections due to mechanical limitations, bacterial resistance, and potential cytotoxicity. To address these challenges, an extracellular matrix (ECM)‐inspired antibacterial fibrous hydrogel featuring an anisotropic topological structure is developed that closely mimics the natural ECM environment. A novel antibacterial agent, PHMB‐VAN‐Gd (PVG), is synthesized by reacting polyhexamethylene biguanide (PHMB) with O‐Vanillin (VAN) to form the Schiff base ligand PHMB‐VAN (PV), fol

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Tang, Xueyun, Li yuchang, Fang Chen, and Wenxing Yang. "Gas concentration and refractive index sensor based on plasmonic induced absorption in metal-insulator-metal waveguide coupled with arc resonators structure." Physica Scripta, May 17, 2024. http://dx.doi.org/10.1088/1402-4896/ad4d2a.

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Abstract In this paper, the plasmonic induced absorption (PIA) effect is numerically studied in a plasmonic metal-insulator-metal (MIM) waveguide coupled with disk and arc-shaped resonators. The PIA spectrum characteristics and magnetic field distributions are investigated by the Finite difference-time domain method (FDTD) method, the PIA effect originated from the coupling of two resonance modes excited by the disk resonator and the arc-shaped resonator. The coupling mode theory (CMT) is used to fit the PIA transmission spectrum, and the calculated result fits well with the simulated spectrum

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Sahu, Rakesh, and Kamal Shah. "Interesting Metformin-Based Derivatives with Versatile Pharmacology." Current Organic Chemistry 29 (January 24, 2025). https://doi.org/10.2174/0113852728361956241220051749.

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Metformin is a popular biguanide medicine because of its efficacy and inexpensive cost. Over time, other applications of metformin were found, and the advantages of metformin for diverse conditions such as anticancer, anti-inflammatory, anticoagulant, antimicrobial, and many more were studied. Although the underlying mechanism of these numerous benefits remains unknown, repurposing it is a smart concept, as it offers several advantages, including reduced development and research costs. However, taking it as-is may result in unwanted pharmacokinetics and mild to severe adverse effects. To overc

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Słubik, Anna, Iwona Masłowska-Lipowicz, Dorota Wieczorek, and Łucja Wyrębska. "Poly(hexamethylene biguanide) salicylate as a novel ionic liquid with antibacterial properties in the production of poly(vinyl alcohol) films." Materials Research Express, September 16, 2022. http://dx.doi.org/10.1088/2053-1591/ac92cb.

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Abstract The presented work describes the effect of poly(hexamethylene biguanide) salicylate (PHMB-SA) ionic liquid on the properties of poly(vinyl alcohol) film. The ionic liquid synthetized is used as an antimicrobial agent. The ionic liquid consist of the poly(hexamethylene biguanide) cation and the salicylic anion, which exhibit synergistic antibacterial and bacteriostatic properties. The structure of obtained new ionic liquid was confirmed by infrared spectroscopy and nuclear magnetic resonance. Additionally, the article describes a simple method of producing an antibacterial PVA-based fi

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Barthold, Douglas, Laura E. Gibbons, Zachary A. Marcum, et al. "Alzheimer’s Disease-Related Neuropathology Among Patients with Medication Treated Type 2 Diabetes in a Community-Based Autopsy Cohort." Journal of Alzheimer's Disease, August 14, 2021, 1–10. http://dx.doi.org/10.3233/jad-210059.

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Background: Diabetes is a risk factor for Alzheimer’s disease and related dementias (ADRD). Epidemiologic evidence shows an association between diabetes medications and ADRD risk; cell and mouse models show diabetes medication association with AD-related neuropathologic change (ADNC). Objective: This hypothesis-generating analysis aimed to describe autopsy-measured ADNC for individuals who used diabetes medications. Methods: Descriptive analysis of ADNC for Adult Changes in Thought (ACT) Study autopsy cohort who used diabetes medications, including sulfonylureas, insulin, and biguanides; total

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Li, Tao, Zhi-Jing Xu, Shu-Ting Zhang, Jia Xu, Piaopiao Pan, and Ning-Yi Zhou. "Discovery of a Ni2+-dependent heterohexameric metformin hydrolase." Nature Communications 15, no. 1 (2024). http://dx.doi.org/10.1038/s41467-024-50409-7.

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AbstractThe biguanide drug metformin is a first-line blood glucose-lowering medication for type 2 diabetes, leading to its presence in the global environment. However, little is known about the fate of metformin by microbial catabolism. Here, we characterize a Ni2+-dependent heterohexameric enzyme (MetCaCb) from the ureohydrolase superfamily, catalyzing the hydrolysis of metformin into guanylurea and dimethylamine. Either subunit alone is catalytically inactive, but together they work as an active enzyme highly specific for metformin. The crystal structure of the MetCaCb complex shows the coor

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Sun, Jiazheng, Shuxiang Xiong, Qiong Wu, Wei Wang, and Wei Wu. "The Preparation of Nanosized Pd/ZSM-23 Bifunctional Catalysts for n-Hexadecane Hydroisomerization by Employing PHMB as the Growth Modifier." Transactions of Tianjin University, December 17, 2023. http://dx.doi.org/10.1007/s12209-023-00377-8.

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AbstractThe development of highly effective metal–zeolite bifunctional catalysts for the hydroisomerization of n-alkanes is a paramount strategy to produce second-generation biofuels with high quality. In this study, polyhexamethylene biguanide hydrochloride (PHMB) is precisely added to the initial gel to synthesize nanosized ZSM-23 zeolites (Z23-xPH). Due to orientation adsorption and steric hindrance effects of PHMB, each sample of Z23-xPH demonstrates enhanced mesoporosity in comparison with the conventional Z23-C zeolite. Furthermore, the Brønsted acid density of the Z23-xPH samples is als

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Das, AsimK. "Kinetics and mechanism of reactions of bis(biguanide)copper(II) ion with glycine and ?-alanine in aqueous media." Transition Metal Chemistry 19, no. 4 (1994). http://dx.doi.org/10.1007/bf00139312.

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Hayes, Joseph, Andreas Lundin, Susanne Wicks, et al. "Repurposing HMG-CoA Reductase Inhibitors, L-Type Calcium Channel Antagonists and Biguanides in Serious Mental Illness: A Within-Individual Cohort Study in National Swedish Data." SSRN Electronic Journal, 2018. http://dx.doi.org/10.2139/ssrn.3208361.

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