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Journal articles on the topic 'Metal-Chelating Peptide'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Matsubara, Teruhiko, Yuko Hiura, and Katsuhiro Kawashiro. "Biocombinatorial Selection of Metal Ion-Chelating Peptides." International Journal of Modern Physics B 17, no. 08n09 (2003): 1324–28. http://dx.doi.org/10.1142/s0217979203018946.

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A phage-displayed library selection was performed to obtain metal ion-chelating peptides. A dodecamer (12-mer) random peptide library was displayed on the surface of filamentous bacterial phage and subjected to an affinity selection. Four rounds of the selection gave fourteen Zn2+-positive phage clones. Enzyme-linked immunosorbent assay showed that the selected clones specifically bound to Zn2+ and Ni2+, but not to Cu2+ and Fe3+. Deduced amino acid sequences of the clones had histidine-rich consensus motifs. These chelating peptides should be applied to designing for metal ion-trapping biomate

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Kani, Hatice K., Ebru K. Kocazorbaz, and Figen Zihnioglu. "Investigation and isolation of peptide based antiglycating agents from various sources." Turkish Journal of Biochemistry 44, no. 5 (2019): 699–705. http://dx.doi.org/10.1515/tjb-2018-0294.

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Abstract Background In this work, peptide based antiglycation agents from various sources against the advanced glycation endproducts (AGE) formation was investigated. Materials and methods As a source of peptides with deglycating activity, Glycine max, Hordeum vulgare, Triticum aestivum, Avena sativa, Prunus dulcis ve Juglans regia were used. The metal chelating activity and antioxidant activity were determined by Cu(II) chelating activity and CUPRAC (Cupric Reducing Antioxidant Capacity) methods. Antidiabetic activity was evaluated through BSA-glucose model. Results Most of the extracts obtai

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3

Chan, Pei-Teng, Patricia Matanjun, Cahyo Budiman, Rossita Shapawi, and Jau-Shya Lee. "Novel Peptide Sequences with ACE-Inhibitory and Antioxidant Activities Derived from the Heads and Bones of Hybrid Groupers (Epinephelus lanceolatus × Epinephelus fuscoguttatus)." Foods 11, no. 24 (2022): 3991. http://dx.doi.org/10.3390/foods11243991.

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The heads and bones of hybrid groupers are potential precursors for angiotensin-converting enzyme (ACE)-inhibitory and antioxidant peptides. The aim of this study was to isolate the dual-action peptides from the Alcalase-treated head and bone hydrolysate of hybrid groupers followed by identification of the novel peptides. The stability of these peptides against stimulated in vitro gastrointestinal digestion (SGID) was also determined. Fraction HB-IV (less than 1 kDa) obtained from ultrafiltration showed the strongest ACE-inhibition ability (IC50: 0.28 mg/mL), which was comparable to the potenc

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Daubit, Isabelle Marie, and Nils Metzler-Nolte. "On the interaction of N-heterocyclic carbene Ir+I complexes with His and Cys containing peptides." Dalton Transactions 48, no. 36 (2019): 13662–73. http://dx.doi.org/10.1039/c9dt01338e.

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In the interaction of an [Ir(+i)(COD)(NHC)Cl] complex with model peptides a chelating motif with a particularly interesting bimetallic peptide-bridged Ir(+iii)–NHC motif was identified with loss of the COD and Cl ligands and oxidation of the metal.

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5

Smith, M. C., T. C. Furman, J. A. Cook, T. Ingolia, and H. Hsiung. "Chelating peptide-immobilized metal ion affinity chromatography." Journal of Inorganic Biochemistry 36, no. 3-4 (1989): 277. http://dx.doi.org/10.1016/0162-0134(89)84385-5.

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6

Alies, Bruno, Jacob D. Wiener, and Katherine J. Franz. "A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity." Chemical Science 6, no. 6 (2015): 3606–10. http://dx.doi.org/10.1039/c5sc00602c.

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7

Irankunda, Rachel, Jairo Andrés Camaño Echavarría, Cédric Paris, et al. "Metal-Chelating Peptides Separation Using Immobilized Metal Ion Affinity Chromatography: Experimental Methodology and Simulation." Separations 9, no. 11 (2022): 370. http://dx.doi.org/10.3390/separations9110370.

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Metal-Chelating Peptides (MCPs), obtained from protein hydrolysates, present various applications in the field of nutrition, pharmacy, cosmetic etc. The separation of MCPs from hydrolysates mixture is challenging, yet, techniques based on peptide-metal ion interactions such as Immobilized Metal Ion Affinity Chromatography (IMAC) seem to be efficient. However, separation processes are time consuming and expensive, therefore separation prediction using chromatography modelling and simulation should be necessary. Meanwhile, the obtention of sorption isotherm for chromatography modelling is a cruc

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Luisi, Grazia, Azzurra Stefanucci, Gokhan Zengin, Marilisa Dimmito, and Adriano Mollica. "Anti-Oxidant and Tyrosinase Inhibitory In Vitro Activity of Amino Acids and Small Peptides: New Hints for the Multifaceted Treatment of Neurologic and Metabolic Disfunctions." Antioxidants 8, no. 1 (2018): 7. http://dx.doi.org/10.3390/antiox8010007.

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Oxidative damage is among the factors associated with the onset of chronic pathologies, such as neurodegenerative and metabolic diseases. Several classes of anti-oxidant compounds have been suggested as having a protective role against cellular stressors, but, in this perspective, peptides’ world represents a poorly explored source. In the present study, the free radical scavenging properties, the metal ion reducing power, and the metal chelating activity of a series of sulfurated amino acids and tripeptides were determined in vitro through canonical assays (DPPH, ABTS, CUPRAC, FRAP, PM, and E

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Lupaescu, Ancuta-Veronica, Ion Sandu, Brindusa Alina Petre, Laura Ion, Catalina-Ionica Ciobanu, and Gabi Drochioiu. "NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction." Revista de Chimie 70, no. 5 (2019): 1784–90. http://dx.doi.org/10.37358/rc.19.5.7215.

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Neurodegenerative diseases, including Alzheimer disease, involve mechanisms such as protein aggregation, free radical generation and oxidative stress. Transition metals such as copper and iron were linked to neurodegenerative pathology. Their pathogenic role consists in generating different reactive oxygen species and damaging tissues or cells through the Fenton reaction. Abnormal metabolism of copper and iron can lead to several chronic pathogenesis. NAP is a small active fragment of activity-dependent neuroprotective protein essential for brain formation. NAP peptide showed neuroprotective p

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Dayob, Kenana, Aygul Zengin, Ruslan Garifullin, et al. "Metal-Chelating Self-Assembling Peptide Nanofiber Scaffolds for Modulation of Neuronal Cell Behavior." Micromachines 14, no. 4 (2023): 883. http://dx.doi.org/10.3390/mi14040883.

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Synthetic peptides are promising structural and functional components of bioactive and tissue-engineering scaffolds. Here, we demonstrate the design of self-assembling nanofiber scaffolds based on peptide amphiphile (PA) molecules containing multi-functional histidine residues with trace metal (TM) coordination ability. The self-assembly of PAs and characteristics of PA nanofiber scaffolds along with their interaction with Zn, Cu, and Mn essential microelements were studied. The effects of TM-activated PA scaffolds on mammalian cell behavior, reactive oxygen species (ROS), and glutathione leve

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Krasae, K., W. Worawattanamateekul, and J. HInsui. "Effects of peptide fractions and amino acids on antioxidant properties of autolyzed tuna viscera protein hydrolysate." Food Research 7, no. 5 (2023): 156–63. http://dx.doi.org/10.26656/fr.2017.7(5).270.

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Tuna viscera as a common waste product from the tuna processing industry contributes to environmental pollution. The effects were determined of peptide fractions and amino acids on the antioxidant properties of protein hydrolysate from tuna viscera. We converted this waste into protein hydrolysate, a high added-value product, using autolysis. Tuna protein hydrolysate was fractionated by ultrafiltration into four fractions (>10 kDa, 5–10 kDa, 1–5 kDa and <1 kDa) and each was examined for its antioxidant properties (DPPH, ABTS, FRAP and metal chelating) and amino acids composition. The MW

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Chen, Lei, Xuanri Shen, and Guanghua Xia. "Effect of Molecular Weight of Tilapia (Oreochromis Niloticus) Skin Collagen Peptide Fractions on Zinc-Chelating Capacity and Bioaccessibility of the Zinc-Peptide Fractions Complexes in Vitro Digestion." Applied Sciences 10, no. 6 (2020): 2041. http://dx.doi.org/10.3390/app10062041.

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To investigate the effect of the molecular weight of tilapia skin collagen peptide fractions on their zinc chelation capacity and the bioaccessibility of their zinc complexes, we evaluated the zinc-chelating ability of different molecular weight peptide, the solubility, and the stability of the complexes during simulated in vitro digestion. Low molecular weight peptide (P1) exhibited a higher zinc-chelating ability, which can be attributed to the variety of metal chelate amino acid residues. The highest solubility and the lowest release of zinc during peptic digestion for the P1-zinc complex a

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13

Kocadağ Kocazorbaz, Ebru. "Exploring the Functional Potential of Breast Milk Protein Hydrolysates: Antiglycation, Antioxidant, Metal Chelation, and Lipid Peroxidation Activities." Sakarya University Journal of Science 28, no. 6 (2024): 1178–87. http://dx.doi.org/10.16984/saufenbilder.1494769.

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The formation of advanced glycation end products (AGEs) is a pivotal factor in the development of various age-related and diabetes associated pathophysiologies, including but not limeted to arthritis, Alzheimer’s disease, atherosclerosis and cataracts. Consequently, the prospect of inhibiting AGE formation emerges as a viable strategy to prevent or halt the advancement of diabetic complications. In the scientific literature, there is still a reluctance to produce bioactive peptides demonstrating antiglycation activity from breast milk. The breast milk protein was hydrolysed using trypsin for 2

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Irankunda, Rachel, Jairo Andrés Camaño Echavarría, Cédric Paris, et al. "Deciphering Interactions Involved in Immobilized Metal Ion Affinity Chromatography and Surface Plasmon Resonance for Validating the Analogy between Both Technologies." Inorganics 12, no. 1 (2024): 31. http://dx.doi.org/10.3390/inorganics12010031.

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Various peptides can be obtained through protein enzymatic hydrolysis. Immobilized metal ion affinity chromatography (IMAC) is one of the methods which can be used to separate metal chelating peptides (MCPs) in a hydrolysate mixture. In this context, this work aims to understand deeply the interactions in IMAC and surface plasmon resonance (SPR) in order to validate experimentally the analogy between both technologies and to be further able to perform IMAC modeling in the next work using peptide sorption isotherm parameters obtained from SPR. Indeed, chromatography modeling can be used to pred

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15

Thompson, Channing C., and Rebecca Y. Lai. "Threonine Phosphorylation of an Electrochemical Peptide-Based Sensor to Achieve Improved Uranyl Ion Binding Affinity." Biosensors 12, no. 11 (2022): 961. http://dx.doi.org/10.3390/bios12110961.

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We have successfully designed a uranyl ion (U(VI)-specific peptide and used it in the fabrication of an electrochemical sensor. The 12-amino acid peptide sequence, (n) DKDGDGYIpTAAE (c), originates from calmodulin, a Ca(II)-binding protein, and contains a phosphothreonine that enhances the sequence’s affinity for U(VI) over Ca(II). The sensing mechanism of this U(VI) sensor is similar to other electrochemical peptide-based sensors, which relies on the change in the flexibility of the peptide probe upon interacting with the target. The sensor was systematically characterized using alternating c

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Magrì, Antonio, Diego La Mendola, and Enrico Rizzarelli. "Nerve Growth Factor Peptides Bind Copper(II) with High Affinity: A Thermodynamic Approach to Unveil Overlooked Neurotrophin Roles." International Journal of Molecular Sciences 22, no. 10 (2021): 5085. http://dx.doi.org/10.3390/ijms22105085.

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Nerve growth factor (NGF) is a protein essential to neurons survival, which interacts with its receptor as a non-covalent dimer. Peptides belonging to NGF N-terminal domain are able to mimic the activity of the whole protein. Such activity is affected by the presence of copper ions. The metal is released in the synaptic cleft where proteins, not yet identified, may bind and transfer to human copper transporter 1 (hCtr1), for copper uptake in neurons. The measurements of the stability constants of copper complexes formed by amyloid beta and hCtr1 peptide fragments suggest that beta-amyloid (Aβ)

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17

Meiss, Cade J., Paige J. Bothwell, and Michael I. Webb. "Ruthenium(II)–arene complexes with chelating quinoline ligands as anti-amyloid agents." Canadian Journal of Chemistry 100, no. 1 (2022): 18–24. http://dx.doi.org/10.1139/cjc-2021-0180.

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Recent recognition of the soluble form of the amyloid-beta (Aβ) peptide as a neurotoxic agent in Alzheimer’s disease (AD) has spurred the development of agents to target this species. Because Aβ is known to chelate metal ions in solution, metal-based therapeutics are uniquely suited to exploit this affinity, where coordination to Aβ has been shown to impact the neurotoxicity of the peptide. Ruthenium(II)–arene complexes are unique candidates for evaluation, as one face of the molecule is blocked by the hydrophobic arene ring, while coordination to the Aβ peptide can occur on the other side of

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18

Iavorschi, Monica, Ancuța-Veronica Lupăescu, Laura Darie-Ion, Maria Indeykina, Gabriela Elena Hitruc, and Brîndușa Alina Petre. "Cu and Zn Interactions with Peptides Revealed by High-Resolution Mass Spectrometry." Pharmaceuticals 15, no. 9 (2022): 1096. http://dx.doi.org/10.3390/ph15091096.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by abnormal extracellular amyloid-beta (Aβ) peptide depositions in the brain. Among amorphous aggregates, altered metal homeostasis is considered a common risk factor for neurodegeneration known to accelerate plaque formation. Recently, peptide-based drugs capable of inhibiting amyloid aggregation have achieved unprecedented scientific and pharmaceutical interest. In response to metal ions binding to Aβ peptide, metal chelation was also proposed as a therapy in AD. The present study analyzes the interactions form

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Irankunda, Rachel, Pauline Jambon, Alexandra Marc, Jairo Andrés Camaño Echavarría, Laurence Muhr, and Laetitia Canabady-Rochelle. "Simulation of Ni2+ Chelating Peptides Separation in IMAC: Prediction of Langmuir Isotherm Parameters from SPR Affinity Data." Processes 12, no. 3 (2024): 592. http://dx.doi.org/10.3390/pr12030592.

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Chromatography modeling for simulation is a tool that can help to predict the separation of molecules inside the column. Knowledge of sorption isotherms in chromatography modeling is a crucial step and methods such as frontal analysis or batch are used to obtain sorption isotherm parameters, but they require a significant quantity of samples. This study aims to predict Langmuir isotherm parameters from Surface Plasmon Resonance (SPR) affinity data (requiring less quantity of sample) to simulate metal chelating peptides (MCPs) separation in Immobilized Metal ion Affinity Chromatography (IMAC),

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20

Smith, Michele C., Thomas C. Furman, and Charles Pidgeon. "Immobilized iminodiacetic acid metal peptide complexes. Identification of chelating peptide purification handles for recombinant proteins." Inorganic Chemistry 26, no. 12 (1987): 1965–69. http://dx.doi.org/10.1021/ic00259a030.

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21

Chunkao, Siriporn, Wirote Youravong, Chutha T. Yupanqui, Adeola M. Alashi, and Rotimi E. Aluko. "Structure and Function of Mung Bean Protein-Derived Iron-Binding Antioxidant Peptides." Foods 9, no. 10 (2020): 1406. http://dx.doi.org/10.3390/foods9101406.

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An iron-binding mung bean protein hydrolysate (MBPH) was prepared using a continuous enzymatic membrane reactor followed by peptide separation on anion-exchange (AEC) and reverse-phase HPLC (RP-HPLC) columns. Amino acid sequences of peptides present in the RP-HPLC fraction with the strongest iron-binding capacity were identified using mass spectrometry, and ten peptides of 5–8 amino acids synthesized for antioxidant characterization. Five fractions (AF1– AF5) with higher iron-binding capacity (88.86 ± 6.43 to 153.59 ± 2.18 mg/g peptide) when compared to the MBPH (36.81 ± 0.93 mg/g peptide) wer

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Sonklin, Chanikan, Natta Laohakunjit, and Orapin Kerdchoechuen. "Assessment of antioxidant properties of membrane ultrafiltration peptides from mungbean meal protein hydrolysates." PeerJ 6 (July 27, 2018): e5337. http://dx.doi.org/10.7717/peerj.5337.

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Background Bioactive peptides can prevent damage associated with oxidative stress in humans when consumed regularly. Recently, peptides have attracted immense interest because of their beneficial functional properties, safety and little or no side effects when used at high concentration. Most antioxidant peptides are small in size, less than 1 kDa, and contains a high proportion of hydrophobic amino acid. Particularly, tyrosine, leucine, alanine, isoleucine, valine, lysine, phenyalanine, cysteine, methionine and histidine in peptide chain exhibited high antioxidant activity. Mungbean meal prot

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Bellotti, Denise, Cinzia Tocchio, Remo Guerrini, Magdalena Rowińska-Żyrek, and Maurizio Remelli. "Thermodynamic and spectroscopic study of Cu(ii) and Zn(ii) complexes with the (148–156) peptide fragment of C4YJH2, a putative metal transporter of Candida albicans." Metallomics 11, no. 12 (2019): 1988–98. http://dx.doi.org/10.1039/c9mt00251k.

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The linker sequence between the two main Cu(ii) and Zn(ii) coordination sites of C4YJH2, a putative metal transporter of Candida albicans, contributes in a non-negligible way to the protein chelating capability.

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Reutzel, Jan, Timm M. Diogo та Armin Geyer. "Reversible Folding of a β-Hairpin Peptide by a Metal-Chelating Amino Acid". Chemistry - A European Journal 23, № 35 (2017): 8450–56. http://dx.doi.org/10.1002/chem.201700698.

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Bíró, Linda, András Ozsváth, Réka Kapitány, and Péter Buglyó. "Pd(II) Binding Strength of a Novel Ambidentate Dipeptide-Hydroxypyridinonate Ligand; A Solution Equilibrium Study." Molecules 27, no. 14 (2022): 4667. http://dx.doi.org/10.3390/molecules27144667.

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A novel ambidentate dipeptide conjugate (H(L1)) containing N-donor atoms of the peptide part and an (O,O) chelate at the hydroxypyridinone (HP) ring is synthesized and characterized. It is hoped that this chelating ligand can be useful to obtain multitargeted Co(III)/Pt(II) dinuclear complexes with anticancer potential. The Pd(II) (as a Pt(II) model but with faster ligand exchange reactions) binding strength of the ligand was studied in an aqueous solution with the combined use of pH-potentiometry and NMR. In an equimolar solution, (L1)− was found to bind Pd(II) via the terminal amino and incr

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Kaugarenia, Nastassia, Sophie Beaubier, Erwann Durand, et al. "Optimization of Selective Hydrolysis of Cruciferins for Production of Potent Mineral Chelating Peptides and Napins Purification to Valorize Total Rapeseed Meal Proteins." Foods 11, no. 17 (2022): 2618. http://dx.doi.org/10.3390/foods11172618.

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Preventing oxidation and microbial spoilage are both major concerns in food industries. In this context, this study aimed to valorize the total rapeseed meal proteins with controlled enzymatic proteolysis to generate potent mineral-chelating peptides from cruciferins while keeping intact the antimicrobial napins. Implementation of proteolysis of total rapeseed protein isolate with the Prolyve® enzyme highlighted an interesting selective hydrolysis of the cruciferins. Hence, the mechanism of this particular hydrolysis was investigated through a Design of Experiments method to obtain a model for

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27

Manhiani, Paljinder, Julie K. Northcutt, and Paul L. Dawson. "Comparative Study of Antioxidant Activity between Carnosine and Its Amino Acid Constituents." Journal of Food Research 12, no. 3 (2023): 69. http://dx.doi.org/10.5539/jfr.v12n3p69.

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A study was conducted to compare and analyze the antioxidant mechanism of carnosine to its constituent amino acids (&beta;-alanine and L-histidine) and to imidazole. Concentrations ranging from 5 to 100 mM of carnosine, &beta;-alanine, L-histidine and imidazole were prepared and antioxidant activity assays (TBARS inhibition, metal chelating activity, free radical scavenging activity) were conducted. The TBARS inhibition of carnosine was due to the imidazole ring present in the histidine and with no inhibition contributed to &beta;-alanine. Metal chelating properties of carnosine wa

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Csire, Gizella, Laetitia Canabady-Rochelle, Marie-Christine Averlant-Petit, Katalin Selmeczi, and Loic Stefan. "Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation." Metallomics 12, no. 8 (2020): 1220–29. http://dx.doi.org/10.1039/d0mt00103a.

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Ibáñez, Alfredo J., Alexander Muck, and Aleš Svatoš. "Metal-Chelating Plastic MALDI (pMALDI) Chips for the Enhancement of Phosphorylated-Peptide/Protein Signals." Journal of Proteome Research 6, no. 9 (2007): 3842–48. http://dx.doi.org/10.1021/pr070243r.

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Monney, Angèle, Flavia Nastri, and Martin Albrecht. "Peptide-tethered monodentate and chelating histidylidene metal complexes: synthesis and application in catalytic hydrosilylation." Dalton Transactions 42, no. 16 (2013): 5655. http://dx.doi.org/10.1039/c3dt50424g.

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Carrasco-Castilla, Janet, Alan Javier Hernández-Álvarez, Cristian Jiménez-Martínez, et al. "Antioxidant and metal chelating activities of peptide fractions from phaseolin and bean protein hydrolysates." Food Chemistry 135, no. 3 (2012): 1789–95. http://dx.doi.org/10.1016/j.foodchem.2012.06.016.

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Pérez-Gálvez, Raúl, F. Javier Espejo-Carpio, Pedro J. García-Moreno, Antonio Guadix, and Emilia M. Guadix. "Processing of Tuna Head By-Products into Antioxidant Peptide Ingredients for Aquaculture Feeds." Antioxidants 14, no. 7 (2025): 770. https://doi.org/10.3390/antiox14070770.

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This study aimed to produce antioxidant peptide fractions from Skipjack tuna (Katsuwonus pelamis) head by-products through enzymatic hydrolysis and membrane filtration. Raw materials were sequentially hydrolyzed with Alcalase® (4 h) and Flavourzyme® (1 h), reaching a final degree of hydrolysis of 18.5 ± 0.9%. The crude hydrolysate was fractionated using ceramic membranes with molecular weight cut-offs of 8, 3, and 1 kDa. Some peptide fractions presented a relevant proportion of short-chain peptides (>50% w/w) and free amino acids (>10% w/w), as well as a high content of essential amino a

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O.O., Odekanyin,, Oriyomi, V.O, Olubayo, T., and Okhuevbie, R. "In vitro Antioxidant Bioactivity of Enzymatically-Produced Tilapia zillii and Oreochromis niloticus Muscle Protein Hydrolysates: Potential Application in Health and Nutrition." Asian Journal of Research in Biochemistry 15, no. 3 (2025): 145–58. https://doi.org/10.9734/ajrb/2025/v15i3396.

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Background & Aims: Hydrolyzed food proteins contain bioactive peptides that can modulate physiological processes that promote good health. In this study, isolated Tilapia zillii muscle protein (TzMP) and Oreochromis niloticus muscle protein (OnMP) were enzymatically hydrolyzed, and their antioxidant properties were evaluated to determine their therapeutic potential in the treatment of oxidative stress-related illness. Methods: The protein hydrolysates of O. niloticus and T. zillii muscle were produced with digestive proteases: pepsin, trypsin, and chymotrypsin, and the degree of hydrolysis

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Andrikopoulos, Prokopis C., and Pavel Čabart. "The chromatin remodeler SMARCA5 binds to d-block metal supports: Characterization of affinities by IMAC chromatography and QM analysis." PLOS ONE 19, no. 10 (2024): e0309134. http://dx.doi.org/10.1371/journal.pone.0309134.

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The ISWI family protein SMARCA5 contains the ATP-binding pocket that coordinates the catalytic Mg2+ ion and water molecules for ATP hydrolysis. In this study, we demonstrate that SMARCA5 can also possess an alternative metal-binding ability. First, we isolated SMARCA5 on the cobalt column (IMAC) to near homogeneity. Examination of the interactions of SMARCA5 with metal-chelating supports showed that, apart from Co2+, it binds to Cu2+, Zn2+ and Ni2+. The efficiency of the binding to the last-listed metal was influenced by the chelating ligand, resulting in a strong preference for Ni-NTA over th

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Ciaglia, Tania, Maria Rosaria Miranda, Simone Di Micco, et al. "Neuroprotective Potential of Indole-Based Compounds: A Biochemical Study on Antioxidant Properties and Amyloid Disaggregation in Neuroblastoma Cells." Antioxidants 13, no. 12 (2024): 1585. https://doi.org/10.3390/antiox13121585.

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Based on the established neuroprotective properties of indole-based compounds and their significant potential as multi-targeted therapeutic agents, a series of synthetic indole–phenolic compounds was evaluated as multifunctional neuroprotectors. Each compound demonstrated metal-chelating properties, particularly in sequestering copper ions, with quantitative analysis revealing approximately 40% chelating activity across all the compounds. In cellular models, these hybrid compounds exhibited strong antioxidant and cytoprotective effects, countering reactive oxygen species (ROS) generated by the

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Kumar, Lakshmanan Vinoth, Robinson Jeyashakila, Sarojini A., Vignaesh Dhanabalan, and Marimuthu Manivannan. "In vitro bioaccessibility and antioxidant properties of unicorn leatherjacket fish (Aluterus monoceros) skin collagen peptides prepared using crude collagenase enzyme isolated from fish fins." Brazilian Journal of Development 10, no. 6 (2024): e70488. http://dx.doi.org/10.34117/bjdv10n6-029.

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In this study unicorn leatherjacket (Aluterus monoceros) fish skin collagen was hydrolyzed with the crude collagenase extracted from the fish fins discarded as by-product at three different temperature viz. 50C (CP-5), 250C (CP-25) and 500C (CP-50) to obtain collagen peptide of three molecular mass fraction viz., <30kDa, <10kDa and <3kDa by ultra-filtration using TFF system. The collagenase extracted from fins had a MW of 29kDa and hydrolyzed skin collagen to molecular masses <24kDa efficiently with a DH ranging from 6.6-7.6%. CP-5 peptides with <3kDa showed the maximum antioxid

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Kjærgaard, Kristian, Jack K. Sørensen, Mark A. Schembri, and Per Klemm. "Sequestration of Zinc Oxide by Fimbrial Designer Chelators." Applied and Environmental Microbiology 66, no. 1 (2000): 10–14. http://dx.doi.org/10.1128/aem.66.1.10-14.2000.

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ABSTRACT Type 1 fimbriae are surface organelles of Escherichia coli. By engineering a structural component of the fimbriae, FimH, to display a random peptide library, we were able to isolate metal-chelating bacteria. A library consisting of 4 × 107 independent clones was screened for binding to ZnO. Sequences responsible for ZnO adherence were identified, and distinct binding motifs were characterized. The sequences selected exhibited various degrees of affinity and specificity towards ZnO. Competitive binding experiments revealed that the sequences recognized only the oxide form of Zn. Intere

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Floresta, Giuseppe, George P. Keeling, Siham Memdouh, Levente K. Meszaros, Rafael T. M. de Rosales, and Vincenzo Abbate. "NHS-Functionalized THP Derivative for Efficient Synthesis of Kit-Based Precursors for 68Ga Labeled PET Probes." Biomedicines 9, no. 4 (2021): 367. http://dx.doi.org/10.3390/biomedicines9040367.

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Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low iron concentrations and their high affinities for oxophilic trivalent metal ions have led to their development for new applications as bifunctional chelators for the radiometal gallium-68 (68Ga). THP-peptide bioconjugates rapidly and quantitatively complex 68Ga at room temperature, neutral pH, and micromolar ligand concentrations, making them amenable to kit-based radiosynthesis of 68Ga PET radiopharmaceuticals. With the aim to produce an N-hydroxysuccinimide-(NHS)-THP reagent for kit-based 68Ga-labeling and PET ima

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ZHANG, Fang L., and Patrick J. CASEY. "Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I." Biochemical Journal 320, no. 3 (1996): 925–32. http://dx.doi.org/10.1042/bj3200925.

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Protein geranylgeranyltransferase type-I (GGTase-I) transfers a geranylgeranyl group from the prenyl donor geranylgeranyl diphosphate (GGPP) to the cysteine residue of substrate proteins containing a C-terminal CaaX-motif (a sequence motif of proteins consisting of an invariant Cys residue fourth from the C-terminus). The GGTase-I heterodimer contains one atom of zinc, and this metal is required for enzyme activity. In this regard, GGTase-I is similar to the related enzyme protein farnesyltransferase (FTase); the latter enzyme also requires Mg2+ for activity. The current studies were undertake

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Caragounis, Aphrodite, Tai Du, Gulay Filiz та ін. "Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands". Biochemical Journal 407, № 3 (2007): 435–50. http://dx.doi.org/10.1042/bj20070579.

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Biometals have an important role in AD (Alzheimer's disease) and metal ligands have been investigated as potential therapeutic agents for treatment of AD. In recent studies the 8HQ (8-hydroxyquinoline) derivative CQ (clioquinol) has shown promising results in animal models and small clinical trials; however, the actual mode of action in vivo is still being investigated. We previously reported that CQ–metal complexes up-regulated MMP (matrix metalloprotease) activity in vitro by activating PI3K (phosphoinositide 3-kinase) and JNK (c-jun N-terminal kinase), and that the increased MMP activity re

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Nowak, J., and H. Tsai. "The yeast aminopeptidase Y." Canadian Journal of Microbiology 34, no. 2 (1988): 118–24. http://dx.doi.org/10.1139/m88-024.

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A metal-dependent aminopeptidase (EC 3.4.11.-), designated APase Y, has been purified to homogeneity by conventional methods. The enzyme is composed of a single polypeptide chain with molecular mass of 102 kilodaltons, estimated by sodium dodecyl sulphate – polyacrylamide gel electrophoresis, with a blocked N-terminal amino acid. It possesses neither endopeptidase nor carboxypeptidase activity and is strongly inhibited by metal-chelating agents, Zn2+, and the protein inhibitor from Neurospora crassa. APase Y is insensitive to Cl anions, S—S reducing reagents, serine protease inhibitors, and th

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Smith, M. C., T. C. Furman, T. D. Ingolia, and C. Pidgeon. "Chelating peptide-immobilized metal ion affinity chromatography. A new concept in affinity chromatography for recombinant proteins." Journal of Biological Chemistry 263, no. 15 (1988): 7211–15. http://dx.doi.org/10.1016/s0021-9258(18)68629-6.

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Famuwagun, Akinsola A., Adeola M. Alashi, Saka O. Gbadamosi, et al. "Effect of Protease Type and Peptide Size on the In Vitro Antioxidant, Antihypertensive and Anti-Diabetic Activities of Eggplant Leaf Protein Hydrolysates." Foods 10, no. 5 (2021): 1112. http://dx.doi.org/10.3390/foods10051112.

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Solanum macrocarpon (eggplant) leaf protein isolate (ELI) was hydrolyzed using four different enzymes to produce hydrolysates from alcalase (AH), chymotrypsin (CH) pepsin (PH) and trypsin (TH). CH had an overall stronger antioxidant property and was separated using ultrafiltration membranes into <1, 1–3 and 3–5 kDa peptide fractions. Gel-permeation chromatography confirmed conversion of the ELI (average of 22 kDa) into protein hydrolysates that contained smaller peptides (<6 kDa). A total of 23 peptides consisting of tri and tetrapeptides were identified from the CH, which is a wider spe

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Ahmadi, Mahmoud Kamal, Samar Fawaz, Charles H. Jones, Guojian Zhang, and Blaine A. Pfeifer. "Total Biosynthesis and Diverse Applications of the Nonribosomal Peptide-Polyketide Siderophore Yersiniabactin." Applied and Environmental Microbiology 81, no. 16 (2015): 5290–98. http://dx.doi.org/10.1128/aem.01373-15.

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ABSTRACTYersiniabactin (Ybt) is a mixed nonribosomal peptide-polyketide natural product natively produced by the pathogenYersinia pestis. The compound enables iron scavenging capabilities upon host infection and is biosynthesized by a nonribosomal peptide synthetase featuring a polyketide synthase module. This pathway has been engineered for expression and biosynthesis usingEscherichia colias a heterologous host. In the current work, the biosynthetic process for Ybt formation was improved through the incorporation of a dedicated step to eliminate the need for exogenous salicylate provision. Wh

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Kreutzer, Martin F., Hirokazu Kage, Peter Gebhardt, et al. "Biosynthesis of a Complex Yersiniabactin-Like Natural Product via themicLocus in Phytopathogen Ralstonia solanacearum." Applied and Environmental Microbiology 77, no. 17 (2011): 6117–24. http://dx.doi.org/10.1128/aem.05198-11.

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ABSTRACTA genome mining study in the plant pathogenic bacteriumRalstonia solanacearumGMI1000 unveiled a polyketide synthase/nonribosomal peptide synthetase gene cluster putatively involved in siderophore biosynthesis. Insertional mutagenesis confirmed the respective locus to be operational under iron-deficient conditions and spurred the isolation of the associated natural product. Bioinformatic analyses of the gene cluster facilitated the structural characterization of this compound, which was subsequently identified as the antimycoplasma agent micacocidin. The metal-chelating properties of mi

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Hu, Yangfan, Huan Luo, Vasudeva Reddy Netala, He Li, Zhijun Zhang, and Tianyu Hou. "Comprehensive Review of Biological Functions and Therapeutic Potential of Perilla Seed Meal Proteins and Peptides." Foods 14, no. 1 (2024): 47. https://doi.org/10.3390/foods14010047.

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This comprehensive review explores the biological functions of Perilla frutescens seed proteins and peptides, highlighting their significant potential for health and therapeutic applications. This review delves into the mechanisms through which perilla peptides combat oxidative stress and protect cells from oxidative damage, encompassing free radical scavenging, metal chelating, in vivo antioxidant, and cytoprotective activities. Perilla peptides exhibit robust anti-aging properties by activating the Nrf2 pathway, enhancing cellular antioxidant capacity, and supporting skin health through the

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Cendron, Andrea, Martina Chianese, Kamil Zarzycki, et al. "Chelating Properties of N6O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes." Molecules 29, no. 23 (2024): 5708. https://doi.org/10.3390/molecules29235708.

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This study focuses on the use of three isostructural N6O donor ligands, specifically known to form complexes with copper ions, to chelate Cu(II) from aqueous solutions. The corresponding Cu(II) complexes feature a dinuclear copper core mimicking the active site of natural superoxide dismutase (SOD) enzymes while also creating a coordination environment favorable for catalase (CAT) activity, being thus appealing as catalytic antioxidant systems. Given the critical role of copper dysregulation in the pathophysiology of Alzheimer’s disease (AD), these complexes may help mitigate the harmful effec

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Amoscato, Andrew A., Damon A. Prenovitz, and Michael T. Lotze. "Rapid Extracellular Degradation of Synthetic Class I Peptides by Human Dendritic Cells." Journal of Immunology 161, no. 8 (1998): 4023–32. http://dx.doi.org/10.4049/jimmunol.161.8.4023.

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Abstract Dendritic cells (DCs) effectively process exogenous and endogenous Ag and present peptide in the context of both class I and class II molecules. We have demonstrated that peripheral blood DCs efficiently degrade synthetic class I peptides at their cell surface within minutes as determined by analyzing DC supernatants by HPLC. Fragments were verified as bona fide cleavage products by direct sequencing using collision-induced dissociation tandem mass spectrometry. The predominant degradative activities were 1) not secreted but associated with activity at the plasma membrane, 2) ecto-ori

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Fashakin, Olumide Oluwatoyosi, Pipat Tangjaidee, Kridsada Unban, et al. "Isolation and Identification of Antioxidant Peptides Derived from Cricket (Gryllus bimaculatus) Protein Fractions." Insects 14, no. 8 (2023): 674. http://dx.doi.org/10.3390/insects14080674.

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Crickets contain high protein content that can be used to improve nutrition but are less exploited. This study was conducted to isolate different Cricket Protein Fractions including albumin, globulin, glutelin, and prolamin. All fractions were characterized and hydrolyzed by commercial enzymes. The results showed that the glutelin fractions had the highest extraction yields with 53.9 ± 2.12% (p < 0.05). Moreover, glutelin hydrolysate fraction prepared by Alcalase with a 16.35 ±0.29% hydrolysis degree was selected for further purification because of their high antioxidant activities, includi

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González-Ortega, Omar, and Roberto Guzmán. "Reversible Immobilization of Chelating Affinity Surfactants on Reversed Phase Adsorbents for Protein and Peptide Separations under Metal Affinity Chromatography." American Journal of Analytical Chemistry 05, no. 14 (2014): 932–44. http://dx.doi.org/10.4236/ajac.2014.514101.

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