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Relevant bibliographies by topics / Metal transporters, ZIPs

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Academic literature on the topic 'Metal transporters, ZIPs'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "Metal transporters, ZIPs"

1

Robe, Kevin, Linnka Lefebvre-Legendre, Fabienne Cleard, and Marie Barberon. "Four ZIPs contribute to Zn, Fe, Cu and Mn acquisition at the outer root domain." PLOS Genetics 21, no. 7 (2025): e1011796. https://doi.org/10.1371/journal.pgen.1011796.

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Zinc (Zn), an essential micronutrient, plays a crucial role in plant development. However, the specific transporters involved in Zn uptake from the soil remain unclear in dicotyledonous plants. Using promoter-reporter lines in Arabidopsis thaliana, we identified several ZIP (Zn-regulated transporter, Iron-regulated transporter (IRT)-like Protein) family members that are expressed in the epidermis and potentially involved in Zn acquisition from the outer root domain. ZIP2, ZIP3, ZIP5 and ZIP8 predominantly localize to the plasma membrane of epidermal and cortical cells, supporting their potenti

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Satarug, Soisungwan, Scott H. Garrett, Seema Somji, Mary Ann Sens, and Donald A. Sens. "Aberrant Expression of ZIP and ZnT Zinc Transporters in UROtsa Cells Transformed to Malignant Cells by Cadmium." Stresses 1, no. 2 (2021): 78–89. http://dx.doi.org/10.3390/stresses1020007.

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Maintenance of zinc homeostasis is pivotal to the regulation of cell growth, differentiation, apoptosis, and defense mechanisms. In mammalian cells, control of cellular zinc homeostasis is through zinc uptake, zinc secretion, and zinc compartmentalization, mediated by metal transporters of the Zrt-/Irt-like protein (ZIP) family and the Cation Diffusion Facilitators (CDF) or ZnT family. We quantified transcript levels of ZIP and ZnT zinc transporters expressed by non-tumorigenic UROtsa cells and compared with those expressed by UROtsa clones that were experimentally transformed to cancer cells

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Bin, Bum-Ho, Juyeon Seo, and Sung Tae Kim. "Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells." Journal of Immunology Research 2018 (October 2, 2018): 1–9. http://dx.doi.org/10.1155/2018/9365747.

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Zinc is an important trace metal in immune systems, and zinc transporters are involved in many immune responses. Recent advances have revealed the structural and biochemical bases for zinc transport across the cell membrane, with clinical implications for the regulation of zinc homeostasis in immune cells like dendritic cells, T cells, B cells, and mast cells. In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters. First, Zrt-/Irt-like proteins (ZIPs) mediate the zinc influx from the extracellular or lumi

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Becares, Eva Ramos, Per Amstrup Pedersen, Pontus Gourdon, and Kamil Gotfryd. "Overproduction of Human Zip (SLC39) Zinc Transporters in Saccharomyces cerevisiae for Biophysical Characterization." Cells 10, no. 2 (2021): 213. http://dx.doi.org/10.3390/cells10020213.

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Zinc constitutes the second most abundant transition metal in the human body, and it is implicated in numerous cellular processes, including cell division, DNA and protein synthesis as well as for the catalytic activity of many enzymes. Two major membrane protein families facilitate zinc homeostasis in the animal kingdom, i.e., Zrt/Irt-like proteins (ZIPs aka solute carrier 39, SLC39, family) and Zn transporters (ZnTs), essentially conducting zinc flux in the opposite directions. Human ZIPs (hZIPs) regulate import of extracellular zinc to the cytosol, being critical in preventing overaccumulat

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Zheng, Jia, Yukang Yue, Yuting Zhu, et al. "Zinc Enhances Cadmium Accumulation in Shoots of Hyperaccumulator Solanum nigrum by Improving ATP-Dependent Transport and Alleviating Toxicity." Plants 13, no. 17 (2024): 2528. http://dx.doi.org/10.3390/plants13172528.

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Solanum nigrum is a cadmium (Cd) and zinc (Zn) accumulator with potential for phytoextraction of soil contaminated with heavy metals. However, how Zn affects Cd accumulation in S. nigrum remains unclear. In this study, S. nigrum seedlings were treated with 100 μmol·L−1 Zn (Zn100), 100 μmol·L−1 Cd (Cd100), and the Zn and Cd combination (Zn100+Cd100) for 10 days under hydroponic culture. Compared with Cd100, the Cd content in stems, leaves, and xylem saps was 1.8, 1.6, and 1.3 times more than that in Zn100+Cd100, respectively. In addition, the production of reactive oxygen species in leaves was

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Chen, Xiaojiao, Yueyao Tang, Hao Zhang, et al. "Physiological, Transcriptome, and Metabolome Analyses Reveal the Tolerance to Cu Toxicity in Red Macroalgae Gracilariopsis lemaneiformis." International Journal of Molecular Sciences 25, no. 9 (2024): 4770. http://dx.doi.org/10.3390/ijms25094770.

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Heavy metal copper (Cu) will inevitably impact the marine macroalgae Gracilariopsis lemaneiformis (G. lemaneiformis), which is a culture of economic importance along China’s coastline. In this study, the detoxification mechanism of Cu stress on G. lemaneiformis was revealed by assessing physiological indicators in conjunction with transcriptome and metabolome analyses at 1 d after Cu stress. Our findings revealed that 25 μM Cu stimulated ROS synthesis and led to the enzymatic oxidation of arachidonic acid residues. This process subsequently impeded G. lemaneiformis growth by suppressing photos

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Kambe, Taiho, Jim Geiser, Brett Lahner, David E. Salt, and Glen K. Andrews. "Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294, no. 5 (2008): R1474—R1481. http://dx.doi.org/10.1152/ajpregu.00130.2008.

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Subfamily II of the solute carrier (Slc)39a family contains three highly conserved members (ZIPs 1–3) that share a 12-amino acid signature sequence present in the putative fourth transmembrane domain and function as zinc transporters in transfected cells. The physiological significance of this genetic redundancy is unknown. Here we report that the complete elimination of all three of these Zip genes, by targeted mutagenesis and crossbreeding mice, causes no overt phenotypic effect. When mice were fed a zinc-adequate diet, several indicators of zinc status were indistinguishable between wild-ty

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Figueira, Antonio, Ederson Akio Kido, and Raul Santin Almeida. "Identifying sugarcane expressed sequences associated with nutrient transporters and peptide metal chelators." Genetics and Molecular Biology 24, no. 1-4 (2001): 207–20. http://dx.doi.org/10.1590/s1415-47572001000100028.

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Plant nutrient uptake is an active process, requiring energy to accumulate essential elements at higher levels in plant tissues than in the soil solution, while the presence of toxic metals or excess of nutrients requires mechanisms to modulate the accumulation of ions. Genes encoding ion transporters isolated from plants and yeast were used to identify sugarcane putative homologues in the sugarcane expressed sequence tag (SUCEST) database. Five cluster consensi with sequence homology to plant high-affinity phosphate transporter genes were identified. One cluster consensus allowed the predicti

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Satarug, Soisungwan, David A. Vesey, and Glenda C. Gobe. "The Evolving Role for Zinc and Zinc Transporters in Cadmium Tolerance and Urothelial Cancer." Stresses 1, no. 2 (2021): 105–18. http://dx.doi.org/10.3390/stresses1020009.

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Cadmium (Cd) is an environmental toxicant with serious public health consequences due to its persistence within arable soils, and the ease with which it enters food chains and then, accumulates in human tissues to induce a broad range of adverse health effects. The present review focuses on the role of zinc (Zn), a nutritionally essential metal, to protect against the cytotoxicity and carcinogenicity of Cd in urinary bladder epithelial cells. The stress responses and defense mechanisms involving the low-molecular-weight metal binding protein, metallothionein (MT), are highlighted. The efflux a

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Cousins, Robert J. "Gastrointestinal Factors Influencing Zinc Absorption and Homeostasis." International Journal for Vitamin and Nutrition Research 80, no. 45 (2010): 243–48. http://dx.doi.org/10.1024/0300-9831/a000030.

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Diet-derived luminal factors have a major influence on zinc available for uptake across the apical membrane of enterocytes. Malabsorption and possibly intestinal microbiota limit this zinc availability. The transporter ZIP4 is expressed along the entire gastrointestinal tract and acts as a major processor of dietary zinc for loading into enterocytes from the apical membrane. Zip4 and other Zip family genes expressed in the gastrointestinal tract are up-regulated in periods of dietary zinc restriction. This provides for powerful homeostatic control. The transporter ZIP14 is up-regulated along t

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Dissertations / Theses on the topic "Metal transporters, ZIPs"

1

REED, JODIE MICHELLE. "CHARACTERIZATION OF THE 8-TRANSMEMBRANE ZIP8 TRANSPORTER: EVIDENCE OF INTRACELLULAR TRAFFICKING IN RESPONSE TO EXTRACELLULAR METAL CONCENTRATIONS." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1187007206.

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Reed, Jodie Michelle. "Characterization of the 8-Transmembrane ZIP8 transporter evidence of intracellular trafficking in response to extracellular metal concentrations /." Cincinnati, Ohio : University of Cincinnati, 2007. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1187007206.

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Thesis (M.S.)--University of Cincinnati, 2007.<br>Advisor: Dr. Timothy P Dalton Title from electronic thesis title page (viewed Dec.6, 2007). Includes abstract. Keywords: Health Sciences, Toxicology Includes bibliographical references.

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Contreras, Aguilera Rubén. "Characterization of the activity of the IRT1 transporter involved in metal uptake in the hyperaccumulator species Noccaea caerulescens." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASB008.

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La croissance et le développement des plantes dépendent de l'activité coordonnée de transporteurs et de canaux membranaires, qui assurent l’absorption, la translocation et le stockage des nutriments essentiels, y compris les métaux. Des éléments comme le fer (Fe), le manganèse (Mn), le nickel (Ni) et le zinc (Zn) jouent un rôle fondamental dans de nombreuses fonctions métaboliques. Toutefois, une accumulation excessive peut devenir toxique, provoquer un stress oxydatif, des carences nutritionnelles ou même entraîner la mort cellulaire. Les plantes ont donc mis en place des mécanismes homéostat

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Flavio, Martini. "Functional analysis of AtZIP4, AtZIP6 and AtZIP9 metal transporters of Arabidopsis thaliana and Expression of Saccharomyces cerevisiae ZRC1 in different plant species." Doctoral thesis, 2019. http://hdl.handle.net/11562/994556.

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Plants have developed a variety of adaptive strategies to take up sufficient quantities of essential macro- and micro-nutrients and avoid their excessive accumulation, which could be toxic. Metal transporters play an essential role in this homeostatic network by controlling the metal efflux across cellular membranes and compartments. The ZIP (ZRT IRT1-like Proteins: Zinc-regulated transporter Iron-regulated transporter 1-like protein) family of metal transporter is involved in this complex network. We have focused on three ZIP-family members: AtZIP4, AtZIP6 and AtZIP9, for which very little in

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Ehsani, Sepehr. "The Significance of the Evolutionary Relationship of Prion Proteins and ZIP Transporters in Health and Disease." Thesis, 2012. http://hdl.handle.net/1807/33986.

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The cellular prion protein (PrPC) is unique amongst mammalian proteins in that it not only has the capacity to aggregate (in the form of scrapie PrP; PrPSc) and cause neuronal degeneration, but can also act as an independent vector for the transmission of disease from one individual to another of the same or, in some instances, other species. Since the discovery of PrPC nearly thirty years ago, two salient questions have remained largely unanswered, namely, (i) what is the normal function of the cellular protein in the central nervous system, and (ii) what is/are the factor(s) involved in the

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Books on the topic "Metal transporters, ZIPs"

1

Hu, Jian. ZIP Metal Ion Transporters. Elsevier Science & Technology, 2023.

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2

Hu, JianBiochemistry Building. ZIP Metal Ion Transporters. Elsevier Science & Technology Books, 2023.

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Book chapters on the topic "Metal transporters, ZIPs"

1

Ajeesh Krishna, T. P., T. Maharajan, S. Ignacimuthu, and S. Antony Ceasar. "Functional, Structural, and Transport Aspects of ZIP in Plants." In Plant Metal and Metalloid Transporters. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-6103-8_10.

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Dempski, Robert E. "The Cation Selectivity of the ZIP Transporters." In Metal Transporters. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-394390-3.00009-4.

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3

Hara, Takafumi, Emi Yoshigai, and Toshiyuki Fukada. "Zinc Transporters and Zinc Signaling in Disease Pathogenesis." In Zinc in Biology. Royal Society of Chemistry, 2025. https://doi.org/10.1039/9781837676583-00229.

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Zinc, an essential trace element, is important for various biological functions such as maintaining protein structure, enzymatic activity, and signaling pathways. Zinc homeostasis is tightly regulated by metal ion transporters, which include the zinc transporter (ZnT) and Zrt/Irt-like protein (ZIP) families. As revealed through human genetic and gene-knockout mouse studies, dysfunction of the zinc transporters and their signaling pathways leads to the pathogenesis of numerous diseases, including cancer, skin diseases, and immune system disorders. Therefore, targeting of the zinc transporters a

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4

Zhang, Yao, Dexin Sui, and Jian Hu. "Expression, purification, crystallization of a ZIP metal transporter from Bordetella bronchiseptica (BbZIP)." In Methods in Enzymology. Elsevier, 2023. http://dx.doi.org/10.1016/bs.mie.2023.05.012.

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5

Vungutur, Varalakshmi, Suetmui Yu, Shannon McCabe, Caitlin Fung, and Ningning Zhao. "A simple and highly reproducible method for the detection of erythrocyte membrane ZIP metal transporters by immunoblotting." In Methods in Enzymology. Elsevier, 2023. http://dx.doi.org/10.1016/bs.mie.2023.04.019.

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