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Journal articles on the topic 'Metallic bone substitute material'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Ueda, Masato, and Masahiko Ikeda. "Controlling of mechanical property in additive manufactured porous titanium by structural control and alloying for bone substitutes." MATEC Web of Conferences 321 (2020): 05004. http://dx.doi.org/10.1051/matecconf/202032105004.

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Mechanical properties of metallic materials can be controlled by not only alloy design but also constructing appropriate structure. A porous material with adequate pore structure showing appropriate mechanical properties has long been sought as the ideal bone substitute, because it exhibits low Young’s modulus and bone ingrowth. Additive manufacturing (AM) can produce metallic tailor-made products such as artificial bone, several joints etc. The purpose of this work was to control the mechanical property of porous Ti by controlling the porous structure. In addition, the characteristics of Ti-Z

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2

de Wild, Michael, Simon Zimmermann, Marcel Obrecht, and Michel Dard. "Marker for the pre-clinical development of bone substitute materials." Current Directions in Biomedical Engineering 3, no. 2 (2017): 711–15. http://dx.doi.org/10.1515/cdbme-2017-0151.

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AbstractThin mechanically stable Ti-cages have been developed for the in-vivo application as X-ray and histology markers for the optimized evaluation of pre-clinical performance of bone graft materials. A metallic frame defines the region of interest during histological investigations and supports the identification of the defect site. This standardization of the procedure enhances the quality of pre-clinical experiments. Different models of thin metallic frameworks were designed and produced out of titanium by additive manufacturing (Selective Laser Melting). The productibility, the mechanica

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Watcharaprapapong, Pornpailin, Wasawat Nakkiew, Wassanai Wattanuchariya, Anirut chaijaruwanit, and Siwasit Pitjamit. "Effect of forming conditions of poly-lactic acid/hydroxyapatite to tensile strength of canine bone fixation plate using full factorial experimental design." MATEC Web of Conferences 192 (2018): 01049. http://dx.doi.org/10.1051/matecconf/201819201049.

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Problems of using metallic bone fixation plates for canine lead to the idea of the replacement with biocomposite materials. In this research, polylactic acid (PLA) blends with hydroxyapatite (HA) powder 5-15% was used as biocomposite material. The specimens were formed by hot compression molding and the experiment in investigating suitable forming condition was based on the 23 full factorials with the center point design of experiment. There are many types of research attempting to develop a prototype of bone fixation plates from a substitute material including forming conditions, in order to

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Taddei, Elisa B., V. A. R. Henriques, Cosme Roberto Moreira Silva, and Carlos Alberto Alves Cairo. "Properties of Porous Ti-35Nb-7Zr-5Ta Processed by the Spacer Method for Use in Biomedical Applications." Materials Science Forum 591-593 (August 2008): 224–29. http://dx.doi.org/10.4028/www.scientific.net/msf.591-593.224.

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Ti-35Nb-7Zr-5Ta alloy is a promising new material for a bone graft substitute with good strength properties and an elastic modulus closer to that of bone than any other metallic material. TNZT samples until 50 vol % porosity were manufactured using ‘‘space holder’’ technique and sintering methods. Irregular ammonium carbonate powders were used as a space holder material. Complete removal carbonate from the green compact was achieved by heating at 200 °C for 5 hours and subsequent sintering at 1600 °C, with heating rate of 10 °C/min. For the alloy microstructural characterization, scanning elec

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Kandil, Islam, Enas Elgendy, Mohamed Anees, and Omar Khashaba. "COMPARISON BETWEEN STRONTIUM RANELATE AND METAL SUBSTITUTED HYDROXYAPATITE AS GRAFTING MATERIALS IN TREATMENT OF PERI-IMPLANT BONY DEFECTS WITH IMMEDIATE IMPLANTS (CLINICAL AND EXPERIMENTAL STUDY)." International Journal of Advanced Research 9, no. 5 (2021): 46–59. http://dx.doi.org/10.21474/ijar01/12808.

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Objective:The aim of this study is to compare between both of strontium ranelate and metallic substitute of hydroxyapatite as grafting materials in the treatment of peri-implant bony defects with immediate placement of dental implant in type I extraction sites within maxillary esthetic zone among clinical and experimental levels. This assessment was based on clinical, radiographic and histological studies. Subjects and Methods: The present study was carried on two types of population among both experimental levels on experimental white albinus rabbits and on clinical level among human patients

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Nasiri-Tabrizi, Bahman, Ali Shokuhfar, and Reza Ebrahimi-Kahrizsangi. "Synthesis and Structural Evaluation of Nanocrystalline Hydroxyapatite Obtained by Mechanochemical Treatment in Polyamide6 Vials." Journal of Nano Research 7 (July 2009): 51–57. http://dx.doi.org/10.4028/www.scientific.net/jnanor.7.51.

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Among various biocompatible materials, hydroxyapatite (HA) is widely used in medical applications. Hydroxyapatite can be used as temporary substitute material for the human bone. Despite of the risk of contamination during milling, the mechanochemical method shows higher reproducibility and low processing cost. In this investigation, the mechanochemical method has been carried out to produce nanocrystalline powders of hydroxyapatite using two experimental procedures (HA1: CaHPO4 + Ca (OH) 2; HA2: CaCO3 + CaHPO4) in polymeric and metallic vials at different milling time. The Effects of milling

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7

Posada, Viviana M., Camila Orozco, Juan Fernando Ramirez Patino, and Patricia Fernandez-Morales. "Human Bone Inspired Design of an Mg Alloy-Based Foam." Materials Science Forum 933 (October 2018): 291–96. http://dx.doi.org/10.4028/www.scientific.net/msf.933.291.

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As an initial step of this research, open cell magnesium foams were obtained by infiltration casting using a preform of salt particles with irregular morphology. Despite this metallic foam was a successful approach to bone replacement scaffold, the properties of a metal foam need to be improved to meet the requirements by accurately adjusting the porous geometry. The tissue scaffold structure should be submissive biologically as well as mechanically and should at best mimic the natural properties of bone to act as an accurate bone substitute. The architectural and mechanical bone scaffold para

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8

Strnadová, M., T. Kučera, M. D. Cevallos Lecaro, J. Strnad, Z. Strnad та A. Nežiková. "A Histological and Radiological Study of Bone Formation around Porous Resorbable β-Tricalcium Phosphate Used as Bone Defect Filling". Key Engineering Materials 631 (листопад 2014): 420–25. http://dx.doi.org/10.4028/www.scientific.net/kem.631.420.

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The purpose of this study was to analyze the histological, histochemical and radiological findings gained from pre-clinical in vitro and in vivo tests and from implantation of ß-tricalcium phosphate PORESORB®-TCP (P). (P) is a bioactive, resorbable, inorganic, crystalline, non-metallic material with osseoconductive properties intended for replacement of bone tissue. The (P) granules (size 1-2mm) were implanted into the tibia of dogs for 3 and 6 months. The formation of 53% and 72% of new bone was observed after 3 and 6 months respectively.Material (P) sized 0.3-0.6 mm was used to fill in the p

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Jinga, Sorin-Ion, Vladut-Petru Toma, Izabela Constantinoiu, Adela Banciu, Daniel-Dumitru Banciu, and Cristina Busuioc. "Development of New Mg- or Sr-Containing Bioactive Interfaces to Stimulate Osseointegration of Metallic Implants." Applied Sciences 10, no. 19 (2020): 6647. http://dx.doi.org/10.3390/app10196647.

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The purpose of this study resides in the design and deposition of several types of bioactive interfaces with complex composition, targeting a superior osseointegration of bone implants. The experimental approach is framed by two oxide systems, SiO2‒CaO‒P2O5‒ZnO‒MgO and SiO2‒CaO‒P2O5‒ZnO‒SrO, while the percentage values were established as optimised solutions for ensuring wear resistance, bioactivity and beneficial effects on cell metabolism and reproduction. Moreover, two methods dedicated to fils growth (pulsed laser deposition and spin coating) were explored as potential variants for coating

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Uzoechi, Samuel C., Goddy C. Okoye, Kennedy O. Ejeta, Benjamin I. Nkem, and Gideon I. Ndubuka. "Effect of Strontium Enhanced Calcium Phosphate Coating on In Vitro Behavior of Human Mesenchymal Stem Cell (hMSC)." Journal of Biomimetics, Biomaterials and Biomedical Engineering 21 (August 2014): 35–44. http://dx.doi.org/10.4028/www.scientific.net/jbbbe.21.35.

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Calcium phosphate is a widely used material as coating for metallic implants. This research describes a biomimetic coating techniques based on deposition of calcium phosphate films on a Ti6Al4V plates that was used to study the effect of strontium additive on the behavior of hMSCs. In this study, strontium additive was homogenously deposited onto calcium phosphate films on a Ti6AlV plates by using a biomimetic techniques. Strontium affected composition and morphology of calcium phosphate deposited on a Ti6Al4V plates to a varying degree, according to concentration of solutions used. The effect

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Kornicka, K., R. Walczak, A. Mucha, and K. Marycz. "Released from ZrO2/SiO2 coating resveratrol inhibits senescence and oxidative stress of human adipose-derived stem cells (ASC)." Open Chemistry 16, no. 1 (2018): 481–95. http://dx.doi.org/10.1515/chem-2018-0039.

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AbstractThe rapid aging of the population results in increased number of metabolic and degenerative disorders, especially in the elderly.Thus, a novel approach in the fields of orthopedic and reconstructive surgery for bone regeneration is strongly desirable. A new perspective in the therapy of bone fractures is tissue engineering which combines living cells with biomaterials to develop modern substitutes that can restore tissue functions. Metallic biomaterials, including stainless steel and pure titanium, have been extensively used for the fabrication of surgical implants over decades. Chemic

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MUNIR, GILLIAN, JIE HUANG, MOHAN EDIRISINGHE, RAFIQUE NANGREJO, and WILLIAM BONFIELD. "ELECTROHYDRODYNAMIC PROCESSING OF CALCIUM PHOSPHATES: COATING AND PATTERNING FOR MEDICAL IMPLANTS." Nano LIFE 02, no. 01 (2012): 1250008. http://dx.doi.org/10.1142/s1793984411000426.

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Hydroxyapatite (HA)-coated metallic prostheses, which combine the osteoconductivity of HA and high strength of metallic alloys, have been increasingly the choice of joint replacement prostheses by surgeons as the general population lives longer. Surface modification of metallic implant surfaces is one of the key focal points to implantation technology. In addition to material chemistry, surface topography has been found to positively impact cellular response and is able to enhance the life time of the implant. Recently, a new technique, template-assisted electrohydrodynamic atomization (TAEA)

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13

de Groot, K., J. G. C. Wolke, and J. A. Jansen. "Calcium phosphate coatings for medical implants." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212, no. 2 (1998): 137–47. http://dx.doi.org/10.1243/0954411981533917.

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In surgical disciplines where bone has to be repaired, augmented or improved, bone substitutes are essential. Although bone banks, such as Eurotransplant, are founded to supply such substitutes, natural bone is not always adequate. For example, frequently these so-called bone grafts resorb after implantation (1). Further, they cannot be used for joint and tooth replacement, and recently worries have been raised about the transfer of infectious diseases. Therefore, interest has dramatically increased in the use of synthetic materials for replacement of lost or damaged bone tissue. The generic n

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14

Hofmann, M. P., U. Gbureck, C. O. Duncan, M. S. Dover, and J. E. Barralet. "Carvable calcium phosphate bone substitute material." Journal of Biomedical Materials Research Part B: Applied Biomaterials 83B, no. 1 (2007): 1–8. http://dx.doi.org/10.1002/jbm.b.30761.

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15

Mahan, KT, and MJ Carey. "Hydroxyapatite as a bone substitute." Journal of the American Podiatric Medical Association 89, no. 8 (1999): 392–97. http://dx.doi.org/10.7547/87507315-89-8-392.

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A bone substitute eliminates the need for autogenous and allogeneic bone grafting, along with the complications unique to each. Coralline hydroxyapatite is a synthetic bone void filler manufactured from marine coral, which has a natural trabecular structure similar to that of cancellous bone. While initial studies have been promising, the use of coralline hydroxyapatite may be limited in the foot and ankle owing to its inherent mechanical weakness and lack of biodegradation. In this retrospective study, 20 patients who received coralline hydroxyapatite implants were reviewed to determine assoc

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16

SMITH, LYMAN. "Ceramic-Plastic Material as a Bone Substitute." Clinical Orthopaedics and Related Research &NA;, no. 282 (1992): 4???9. http://dx.doi.org/10.1097/00003086-199209000-00002.

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17

Wang, H., Xiao Ping Wang, Jian Dong Ye, Ying Jun Wang, and Ping Gen Rao. "Rheological Properties and Injectability of a Calcium Phosphate Bone Substitute Material." Key Engineering Materials 288-289 (June 2005): 557–60. http://dx.doi.org/10.4028/www.scientific.net/kem.288-289.557.

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A calcium phosphate bone substitute material was prepared and its rheological behavior and injectability were studied in this work. The effects of temperature, L/P ratio and adjuvant on the rheological properties and injectability of the pastes were discussed. The results show that the calcium phosphate bone substitute material is injectable with good fluidity and is suitable for the clinical applications. The rheological behavior and injectability of the bone substitute material can be improved by adding adjuvants and optimizing L/P ratio.

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18

Melnikova, S., E. Zelichenko, B. Zenin, V. Guzeev, and O. Gurova. "Bone substitute material on the basis of natural components." IOP Conference Series: Materials Science and Engineering 66 (October 7, 2014): 012025. http://dx.doi.org/10.1088/1757-899x/66/1/012025.

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19

Thackray, Ania C., Rachel L. Sammons, Lynne E. Macaskie, Ping Yong, Harriet Lugg, and Peter M. Marquis. "Bacterial biosynthesis of a calcium phosphate bone-substitute material." Journal of Materials Science: Materials in Medicine 15, no. 4 (2004): 403–6. http://dx.doi.org/10.1023/b:jmsm.0000021110.07796.6e.

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20

Duta, Liviu, Johny Neamtu, Razvan P. Melinte, et al. "In Vivo Assessment of Bone Enhancement in the Case of 3D-Printed Implants Functionalized with Lithium-Doped Biological-Derived Hydroxyapatite Coatings: A Preliminary Study on Rabbits." Coatings 10, no. 10 (2020): 992. http://dx.doi.org/10.3390/coatings10100992.

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We report on biological-derived hydroxyapatite (HA, of animal bone origin) doped with lithium carbonate (Li-C) and phosphate (Li-P) coatings synthesized by pulsed laser deposition (PLD) onto Ti6Al4V implants, fabricated by the additive manufacturing (AM) technique. After being previously validated by in vitro cytotoxicity tests, the Li-C and Li-P coatings synthesized onto 3D Ti implants were preliminarily investigated in vivo, by insertion into rabbits’ femoral condyles. The in vivo experimental model for testing the extraction force of 3D metallic implants was used for this study. After four

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Dorozhkin, Sergey V. "Calcium Orthophosphate Bioceramics." Eurasian Chemico-Technological Journal 12, no. 3,4 (2010): 247. http://dx.doi.org/10.18321/ectj52.

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The present review is intended to point the readers’ attention to the important subject of calcium orthophosphate bioceramics. Calcium orthophosphates by one-selves appear to be of a special significance for the human beings because they represent the inorganic part of calcified tissues of mammals. Therefore, many types of calcium orthophosphate-based bioceramics possess remarkable biocompatibility and bioactivity. Materials scientists extensively use this property in attempts to construct artificial bone grafts those are either entirely made of or only surface-coated by calcium orthophosphate

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KANEKO, AOI, ERIKO MARUKAWA, and HIROYUKI HARADA. "Hydroxyapatite Nanoparticles as Injectable Bone Substitute Material in a Vertical Bone Augmentation Model." In Vivo 34, no. 3 (2020): 1053–61. http://dx.doi.org/10.21873/invivo.11875.

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Lorenz, Jonas, Mike Barbeck, Robert A. Sader, et al. "Foreign Body Giant Cell–Related Encapsulation of a Synthetic Material Three Years After Augmentation." Journal of Oral Implantology 42, no. 3 (2016): 273–77. http://dx.doi.org/10.1563/aaid-joi-d-15-00133.

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Bone substitute materials of different origin and chemical compositions are frequently used in augmentation procedures to enlarge the local bone amount. However, relatively little data exist on the long-term tissue reactions. The presented case reports for the first time histological and histomorphometrical analyses of a nanocrystaline hydroxyapatite–based bone substitute material implanted in the human sinus cavity after an integration period of 3 years. The extracted biopsy was analyzed histologically and histomorphometrically with focus on the tissue reactions, vascularization, new bone for

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Syam, Syamsiah, Yung-Chieh Cho, Chung-Ming Liu, et al. "An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing." Applied Sciences 10, no. 22 (2020): 8303. http://dx.doi.org/10.3390/app10228303.

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This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also

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Rahyussalim, Ahmad Jabir, Sugeng Supriadi, Aldo Fransiskus Marsetio, Pancar Muhammad Pribadi, and Bambang Suharno. "The potential of carbonate apatite as an alternative bone substitute material." Medical Journal of Indonesia 28, no. 1 (2019): 92–7. http://dx.doi.org/10.13181/mji.v28i1.2681.

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Bone reconstructive surgery has become a common procedure, and bone transplantation has become the second most frequently performed tissue transplantation procedure worldwide. Therefore, the need for bone substitute materials has increased. Artificial bone substitutes exhibit osteoconductive properties and feature several advantages, including abundant resources, low cost, and low donor site morbidity. Carbonate apatite (CO3Ap) is a calcium phosphate ceramic that can be used as a synthetic bone graft. The carbonate content of this ceramic is similar to that of bone apatite. In this review, we

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Eppell, Steven, Weidong Tong, James McMasters, et al. "Minor Review: An Overview of a Synthetic Nanophase Bone Substitute." Materials 11, no. 9 (2018): 1556. http://dx.doi.org/10.3390/ma11091556.

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Material is reviewed that consists of reconstituted collagen fibril gel mineralized in a manner that produces biomimetically sized nanoapatites intimately associated with the fibrils. This gel is formed into usable shapes with a modulus and strength that allow it to be surgically press fitted into bony defects. The design paradigm for the material is that the nanoapatites will dissolve into soluble Ca2+ as the collagen is degraded into RGD-containing peptide fragments due to osteoclastic action. This is intended to signal to the osteoclasts to continue removing the material in a biomimetic fas

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Lorenz, Jonas, Alica Kubesch, Tadas Korzinskas, et al. "TRAP-Positive Multinucleated Giant Cells Are Foreign Body Giant Cells Rather Than Osteoclasts: Results From a Split-Mouth Study in Humans." Journal of Oral Implantology 41, no. 6 (2015): e257-e266. http://dx.doi.org/10.1563/aaid-joi-d-14-00273.

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This study compared the material-specific tissue response to the synthetic, hydroxyapatite-based bone substitute material NanoBone (NB) with that of the xenogeneic, bovine-based bone substitute material Bio-Oss (BO). The sinus cavities of 14 human patients were augmented with NB and BO in a split-mouth design. Six months after augmentation, bone biopsies were extracted for histological and histomorphometric investigation prior to dental implant insertion. The following were evaluated: the cellular inflammatory pattern, the induction of multinucleated giant cells, vascularization, the relative

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Klinkenberg, Ernst Dieter, Hans Georg Neumann, Ulrike Bulnheim, and Joachim Rychly. "The New Art of Bone Graft Substitute Design." Key Engineering Materials 330-332 (February 2007): 959–62. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.959.

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A new method of design and manufacturing of bone graft substitutes is introduced. For the first time it is possible to prepare bone graft substitutes with a directed and controlled pore structure. Furthermore, the formation of sophisticated geometries is feasible. First in vitro investigations with cell cultures show a vital cell growing on the synthetic bone graft material. Numerous applications are possible.

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Yamada, M., T. Ueno, H. Minamikawa, et al. "N-acetyl Cysteine Alleviates Cytotoxicity of Bone Substitute." Journal of Dental Research 89, no. 4 (2010): 411–16. http://dx.doi.org/10.1177/0022034510363243.

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Lack of cytocompatibility in bone substitutes impairs healing in surrounding bone. Adverse biological events around biomaterials may be associated with oxidative stress. We hypothesized that a clinically used inorganic bone substitute is cytotoxic to osteoblasts due to oxidative stress and that N-acetyl cysteine (NAC), an antioxidant amino acid derivative, would detoxify such material. Only 20% of rat calvaria osteoblasts were viable when cultured on commercial deproteinized bovine bone particles for 24 hr, whereas this percentage doubled on bone substitute containing NAC. Intracellular ROS le

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Doi, Kazuya, Reiko Kobatake, Yusuke Makihara, et al. "The development of novel bioactive porous titanium as a bone reconstruction material." RSC Advances 10, no. 38 (2020): 22684–90. http://dx.doi.org/10.1039/d0ra03202f.

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Marchi, Juliana, Christiane Ribeiro, Ana Helena de Almeida Bressiani, and Márcia Martins Marques. "Cell response of calcium phosphate based ceramics, a bone substitute material." Materials Research 16, no. 4 (2013): 703–12. http://dx.doi.org/10.1590/s1516-14392013005000058.

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Yauma Asra, Dina, Kiagus Dahlan, and Yessie Widya Sari. "Synthesis of Bio-composite CHA/PVA/Alginate as Bone Substitute Material." Journal of Physics: Conference Series 1505 (March 2020): 012052. http://dx.doi.org/10.1088/1742-6596/1505/1/012052.

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Honda, Daiki, Akari Takeuchi, and Ishikawa Kunio. "Basic Properties of Starfish Derived Calcium Carbonate and its Phase Transformation to Carbonate Apatite." Key Engineering Materials 529-530 (November 2012): 40–43. http://dx.doi.org/10.4028/www.scientific.net/kem.529-530.40.

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Feasibility of starfish bone to be a source material for apatite bone substitute was investigated in the present study because starfish bone is known to be porous calcium carbonate. Starfish bone was assembly of Mg containing calcite granules. And the calcite granules had fully interconnected porous structure with approximately 20 µm of pore size. After the hydrothermal treatment of the calcite granules in Na2HPO4 aqueous solution, the granules were gradually transformed to apatite. Therefore, starfish derived calcium carbonate would be a candidate of a source material for carbonate apatite bo

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Kruppke, Benjamin, Jana Farack, Alena-Svenja Wagner, et al. "Gelatine modified monetite as a bone substitute material: An in vitro assessment of bone biocompatibility." Acta Biomaterialia 32 (March 2016): 275–85. http://dx.doi.org/10.1016/j.actbio.2015.12.035.

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Lanao, R. P. Félix, J. W. M. Hoekstra, Joop G. C. Wolke, et al. "Bone Regenerative Properties of Injectable Calcium Phosphate/PLGA Cement in an Alveolar Bone Defect." Key Engineering Materials 529-530 (November 2012): 300–303. http://dx.doi.org/10.4028/www.scientific.net/kem.529-530.300.

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Periodontitis is one of the most common inflammatory diseases, which can lead to early tooth loss. The conventional treatment of periodontitis is to arrest the disease progression. Most reconstructive procedures involve application of bone substitutes, barrier membranes or a combination of both into the bony defects. Calcium phosphate cements (CPCs) are the predominant type of bone substitute material used for reasons of injectability and hence perfect filling potential for bone defects. Recently, injectable apatitic CPCs demonstrated to be more rapidly degradable when combined with poly (lact

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Habibie, Sudirman, Agus Hadi Santosa Wargadipura, Dwi Gustiono, et al. "Production and Characterization of Hydroxyapatite Bone Substitute Material Performed from Indonesian Limestone." International journal of Biomedical Engineering and Science 4, no. 1 (2017): 11–23. http://dx.doi.org/10.5121/ijbes.2017.4102.

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Lee, K. S., H. S. Han, Y. C. Kim та ін. "Evaluation of porous β-calcium pyrophosphate as bioresorbable bone graft substitute material". Materials Research Innovations 19, № 2 (2014): 86–90. http://dx.doi.org/10.1179/1433075x14y.0000000215.

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Prasad, Satish C. "Determination of dose enhancement in cortical bone substitute material for electron beams." Medical Physics 18, no. 2 (1991): 324–25. http://dx.doi.org/10.1118/1.596679.

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Knabe, Christine, Marco Lopez Heredia, Dirk Barnemitz, Antje Genzel, Fabian Peters, and Wolf Dietrich Hübner. "Effect of Silicon-Doped Calcium Phosphate Bone Substitutes on Bone Formation and Osteoblastic Phenotype Expression In Vivo." Key Engineering Materials 614 (June 2014): 31–34. http://dx.doi.org/10.4028/www.scientific.net/kem.614.31.

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This study evaluates the effect of two novel particulate silicon-doped calcium phosphate graft materials as compared to the currently clinically used material β-TCP on osteogenesis and bone formation after implantation in critical-size defects the sheep scapula. These materials were developed in order to create biodegradable bone substitute materials that degrade rapidly, but still stimulate osteogenesis at the same time, thereby resulting in bone repair and regeneration with fully functional bone tissue. All bone substitute materials studied facilitated excellent bony regeneration of critical

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Dewi, Anne Handrini, and Andi Triawan. "The Newly Bone Formation with Carbonate Apatite-Chitosan Bone Substitute in the Rat Tibia." Indonesian Journal of Dental Research 1, no. 3 (2015): 154. http://dx.doi.org/10.22146/theindjdentres.10065.

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Large bone defect still represent a major problem in orthopedics. A tissue engineering approach has been proposed where osteogenic cells, bioceramic scaffolds and growth factors can play in a role to the bone repair. Bone consist a mineral phase such as carbonate apatite and an organic phase such as collagen. Synthetic carbonate apatite ceramics are considered as promising alloplastic materials for bone substitute. Chitin is the organic matrix of the hard parts of exoskeleton of insect, crustacean and present in a small amounts in mushrooms. It is an insoluble, similar to cellulose and compose

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Mustafa, Muhammed, and Othman Omar. "Effects of hyaluronic acid on bone graft healing: An experimental study on sheep." Erbil Dental Journal 3, no. 2 (2020): 98–103. http://dx.doi.org/10.15218/edj.2020.14.

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Background and Objectives: : Alloplastic is one of known materials have been used to treat bony defects in oral and maxillofacial region, but the healing is much more slower than auto graft . So many interpositional graft materials like hyaluronic acid and bone morphogenetic protein have been introduced to such material to induce osteoinductivity of graft material. This study aimed to evaluate the histological effect of Hyaluronic acid on bone graft substitute. Patients and methods: An experimental study carried out on 3 domestic sheep 2-4 years old. They divided into two groups, first group (

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Wang, Siwen, Weiyi Wu, Yuhua Liu, et al. "Bone Augmentation of Peri-Implant Dehiscence Defects Using Multilaminated Small Intestinal Submucosa as a Barrier Membrane: An Experimental Study in Dogs." BioMed Research International 2019 (November 16, 2019): 1–11. http://dx.doi.org/10.1155/2019/8962730.

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Objective. The aim of the study is to evaluate the effects of multilaminated small intestinal submucosa (mSIS) combined with bone substitute material to repair peri-implant defects during guided bone regeneration procedures. Methods. Twelve implants were placed in bilateral lower premolars of three beagle dogs, and a peri-implant buccal bone defect (3 mm width and 4 mm height) was created at each implant site. A total of 12 sites were filled with a particulate bone substitute material and then randomly divided into three treatment groups: covered by mSIS membrane (mSIS group), covered by colla

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Ou, Keng-Liang, Ping-Jen Hou, Bai-Hung Huang, et al. "Bone Healing and Regeneration Potential in Rabbit Cortical Defects Using an Innovative Bioceramic Bone Graft Substitute." Applied Sciences 10, no. 18 (2020): 6239. http://dx.doi.org/10.3390/app10186239.

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This study aimed to elucidate the local effect and micro-computed tomographic (μ-CT) assessment following bone implantation of an innovative bioceramic (α-calcium sulfate hemihydrate; α-CSH) on femur lateral condyle cortical bone of rabbit models. The innovative α-CSH bioceramic was synthesized through a green processing technology (microwave irradiation treatment). The bilateral implantation model was performed among 24 New Zealand White rabbits which were divided into three groups based on the type of filling materials: α-CSH, control, and blank. Treatments were performed in defects with 6 m

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Wach, Tomasz, and Marcin Kozakiewicz. "Fast-Versus Slow-Resorbable Calcium Phosphate Bone Substitute Materials—Texture Analysis after 12 Months of Observation." Materials 13, no. 17 (2020): 3854. http://dx.doi.org/10.3390/ma13173854.

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The development of oral surgery and implantology has led to the need for better and more predictable materials. Various substitute materials are now used for bone regeneration. The replacement of scaffolding material by new bone tissue is the most important condition. This study aimed to evaluate the effects of the resorbability of bone substitute materials during regeneration to the jawbone. The study included 88 patients during the 12-month follow-up. All the patients had undergone oral surgical procedures using two different substitute materials—Cerasorb (high-rate resorbable (β-tricalcium

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BARBECK, MIKE, OLE JUNG, RALF SMEETS, et al. "Implantation of an Injectable Bone Substitute Material Enables Integration Following the Principles of Guided Bone Regeneration." In Vivo 34, no. 2 (2020): 557–68. http://dx.doi.org/10.21873/invivo.11808.

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Liu, Jinyi, Patrick R. Schmidlin, Alexander Philipp, Nora Hild, Andrew Tawse-Smith, and Warwick Duncan. "Novel bone substitute material in alveolar bone healing following tooth extraction: an experimental study in sheep." Clinical Oral Implants Research 27, no. 7 (2015): 762–70. http://dx.doi.org/10.1111/clr.12673.

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Rolvien, Tim, Mike Barbeck, Sabine Wenisch, Michael Amling, and Matthias Krause. "Cellular Mechanisms Responsible for Success and Failure of Bone Substitute Materials." International Journal of Molecular Sciences 19, no. 10 (2018): 2893. http://dx.doi.org/10.3390/ijms19102893.

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Bone grafts, i.e., autologous, allogeneic or synthetic bone substitute materials play an increasing role in reconstructive orthopedic surgery. While the indications and materials differ, it is important to understand the cellular mechanisms regarding their integration and remodeling, which are discussed in this review article. Osteoconductivity describes the new bone growth on the graft, while osteoinductivity represents the differentiation of undifferentiated cells into bone forming osteoblasts. The best case is that both mechanisms are accompanied by osteogenesis, i.e., bone modeling and rem

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Wu, Lan, Yu Bao Li, Yi Zuo, Li Zhang, Wei Hu Yang, and Yuan Hua Mu. "Study on the Biomimetic Properties of Bone Substitute Material: Nanohydroxyapatite/Polyamide 66 Composite." Materials Science Forum 510-511 (March 2006): 938–41. http://dx.doi.org/10.4028/www.scientific.net/msf.510-511.938.

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To compare with the human cortical bone, the biomimetic properties of nano-hydroxyapatite/polyamide 66 composite (n-HA/PA66) were preliminarily studied qualitatively and quantitatively with TEM, XRD in crystal morphology, phase composition and crystal structure. A series of structure parameters such as cell lattice parameters (a and c), mean crystallite size and micro-strain were calculated to characterize quantitatively the microstructure of n-HA/PA66 and human cortical bone at the atomic level. The results show that n-HA/PA66 is a good biomimetic biomaterial. But there still are some differe

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Kotrych, Daniel, Szymon Korecki, Paweł Ziętek, et al. "Preliminary results of Highly Injectable Bi-Phasic Bone Substitute (CERAMENT) in the treatment of benign bone tumors and tumor-like lesions." Open Medicine 13, no. 1 (2018): 487–92. http://dx.doi.org/10.1515/med-2018-0072.

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AbstractBackground: CERAMENT™|BONE VOID FILLER is an injectable and moldable ceramic bone substitute material intended for bone voids. The material consists of hydroxyapatite and calcium sulfate hemihydrate. The aim of this study is to present the first long-term results following open curettage of benign bone tumors and tumor-like lesions and void filling with this novel injectable and synthetic bone graft. Methods: Thirty three patients were enrolled into the study between June 2013 and October 2014 .Totally, we treated 24 women and 9 men with a median age of 47 years (range: 22-74). All pat

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Ishida, Haruka, Hisao Haniu, Akari Takeuchi та ін. "In Vitro and In Vivo Evaluation of Starfish Bone-Derived β-Tricalcium Phosphate as a Bone Substitute Material". Materials 12, № 11 (2019): 1881. http://dx.doi.org/10.3390/ma12111881.

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We evaluated starfish-derived β-tricalcium phosphate (Sf-TCP) obtained by phosphatization of starfish-bone-derived porous calcium carbonate as a potential bone substitute material. The Sf-TCP had a communicating pore structure with a pore size of approximately 10 μm. Although the porosity of Sf-TCP was similar to that of Cerasorb M (CM)—a commercially available β-TCP bone filler—the specific surface area was roughly three times larger than that of CM. Observation by scanning electron microscopy showed that pores communicated to the inside of the Sf-TCP. Cell growth tests showed that Sf-TCP imp

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