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Journal articles on the topic 'Metallo-B-lactamase genes'

Author: Grafiati

Published: 18 May 2024

Last updated: 31 July 2025

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1

Garau, Gianpiero, Anne Marie Di Guilmi та Barry G. Hall. "Structure-Based Phylogeny of the Metallo-β-Lactamases". Antimicrobial Agents and Chemotherapy 49, № 7 (2005): 2778–84. http://dx.doi.org/10.1128/aac.49.7.2778-2784.2005.

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ABSTRACTThe metallo-β-lactamases fall into two groups: Ambler class B subgroups B1 and B2 and Ambler class B subgroup B3. The two groups are so distantly related that there is no detectable sequence homology between members of the two different groups, but homology is clearly detectable at the protein structure level. The multiple structure alignment program MAPS has been used to align the structures of eight metallo-β-lactamases and five structurally homologous proteins from the metallo-β-lactamase superfamily, and that alignment has been used to construct a phylogenetic tree of the metallo-β

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Matsumoto, Takehisa, Mika Nagata, Nau Ishimine та ін. "Characterization of CIA-1, an Ambler Class A Extended-Spectrum β-Lactamase from Chryseobacterium indologenes". Antimicrobial Agents and Chemotherapy 56, № 1 (2011): 588–90. http://dx.doi.org/10.1128/aac.05165-11.

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ABSTRACTAn Ambler class A β-lactamase gene,blaCIA-1, was cloned from the reference strainChryseobacterium indologenesATCC 29897 and expressed inEscherichia coliBL21. TheblaCIA-1gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respectively.blaCIA-1-like genes were detected from clinical isolates. In addition to the metallo-β-lactamase IND of Ambler class B,C. indologeneshas a class A ESBL gene,blaCIA-1, located on the chromosome.

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Abbas Aboud, Ali. "Molecular Investigation of Metallo B-Lactamase genes in Klebsiella Pneumoniae Bacteria from Clinical Isolates." Osol Journal for Medical Sciences 2, no. 2 (2024): 19–28. https://doi.org/10.69946/ojms/2024.02.02.03.

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Klebsiella pneumoniae is a significant nosocomial bacteria, that causes a large range of infections e.g. bacteremia, pneumonia, meningitis, and urinary tract infections. The current study intends to detect the existence of specific genes (blaNDM-1, blaNDM-2, blaVIM, blaIMP) associated with metallo-beta-lactamase (MBL) production in multidrug-resistant Klebsiella pneumoniae isolates attained from various clinical isolate. These genes are responsible for conferring resistance to a wide range of antibiotics, making an infection caused by such bacteria difficult to treat. Two hundred and seventy e

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Biedenbach, Douglas J., Krystyna Kazmierczak, Samuel K. Bouchillon, Daniel F. Sahm, and Patricia A. Bradford. "In VitroActivity of Aztreonam-Avibactam against a Global Collection of Gram-Negative Pathogens from 2012 and 2013." Antimicrobial Agents and Chemotherapy 59, no. 7 (2015): 4239–48. http://dx.doi.org/10.1128/aac.00206-15.

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ABSTRACTThe combination of aztreonam plus avibactam is being developed for use in infections caused by metallo-β-lactamase-producingEnterobacteriaceaestrains that also produce serine β-lactamases. Thein vitroactivities of aztreonam-avibactam and comparator antimicrobials were determined against year 2012 and 2013 clinical isolates ofEnterobacteriaceae,Pseudomonas aeruginosa, andAcinetobacter baumanniiusing the broth microdilution methodology recommended by the Clinical and Laboratory Standards Institute (CLSI). A total of 28,501 unique clinical isolates were obtained from patients in 190 medic

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Abaza, Amani F., Soraya A. El Shazly, Heba S. A. Selim, and Gehan S. A. Aly. "Metallo-Beta-Lactamase Producing Pseudomonas aeruginosa in a Healthcare Setting in Alexandria, Egypt." Polish Journal of Microbiology 66, no. 3 (2017): 297–308. http://dx.doi.org/10.5604/01.3001.0010.4855.

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Pseudomonas aeruginosa has emerged as a major healthcare associated pathogen that creates a serious public health disaster in both developing and developed countries. In this work we aimed at studying the occurrence of metallo-beta-lactamase (MBL) producing P. aeruginosa in a healthcare setting in Alexandria, Egypt. This cross sectional study included 1583 clinical samples that were collected from patients admitted to Alexandria University Students’ Hospital. P. aeruginosa isolates were identified using standard microbiological methods and were tested for their antimicrobial susceptibility pat

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Abdullah Mohamed, Maha Assayed, and Mohamed H. Arbab. "Prevalence of Multi Drug Resistant Pseudomonas Species Encoding SPM Metalo Beta Lactamase Gene Collected from Patients with Infected Wound in Khartoum State." SVOA Microbiology 5, no. 4 (2024): 143–47. http://dx.doi.org/10.58624/svoamb.2024.05.052.

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Background: Selection of the most appropriate antibiotic is complicated by the ability of P. aeruginosa to develop resistance to multiple classes of antibacterial agents, even during the course of treating an infection. As in all genes encoding bacteria, metalloB-Lactamases-producing strains (generally multidrug resistant) cause infections that are difficult to treat and resulting in a high mortality and morbidity rates in the community, an increase in both to extend and diversity of metallo-β- lactamases in Pseudomonas aeruginosa severely limits treatment and delay the process of healing the

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Bagheri Josheghani, Sareh, Rezvan Moniri, Farzaneh Firoozeh, Mojtaba Sehat, and Yasaman Dasteh Goli. "Susceptibility Pattern and Distribution of Oxacillinases andblaPER-1Genes among Multidrug ResistantAcinetobacter baumanniiin a Teaching Hospital in Iran." Journal of Pathogens 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/957259.

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Acinetobacter baumannii (A. baumannii)is an important nosocomial pathogen in healthcare institutions.β-Lactamase-mediated resistance is the most common mechanism for carbapenem resistance inA. baumannii. The aim of this study was to determine the antibiotic resistance pattern, to detectOXAencoding genes, class A,blaPER-1, and to detect the presence of ISAba1. A total of 124A. baumanniiisolates were collected from hospitalized patients in a teaching hospital in Kashan, Iran. The susceptibility of isolates to different antibiotics was determined by disk-diffusion method. PCR was used to detectbl

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Vivan, Ana Carolina Polano, Juliana Ferraz Rosa, Camila Fonseca Rizek, et al. "Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates from a university hospital in Brazil." Journal of Infection in Developing Countries 11, no. 05 (2017): 379–86. http://dx.doi.org/10.3855/jidc.8614.

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Introduction: The emergence of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kpn) isolates is attracting significant attention in nosocomial infection settings. K. pneumoniae is the main pathogen that harbours blaKPC genes. Methodology: This study evaluated 54 K. pneumoniae carbapenem-resistant isolates from patients hospitalized at the University Hospital of Londrina, between July 2009 and July 2010. The isolates were phenotypically screened for carbapenemase production and submitted for genotypic confirmation by polymerase chain reaction (PCR) for KPC, metallo-

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Woodford, Neil, Marie-France I. Palepou, Gioia S. Babini, Barry Holmes та David M. Livermore. "Carbapenemases of Chryseobacterium(Flavobacterium) meningosepticum: Distribution ofblaB and Characterization of a Novel Metallo-β-Lactamase Gene, blaB3, in the Type Strain, NCTC 10016". Antimicrobial Agents and Chemotherapy 44, № 6 (2000): 1448–52. http://dx.doi.org/10.1128/aac.44.6.1448-1452.2000.

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ABSTRACT Genes encoding carbapenemases in 15 reference strains ofChryseobacterium (Flavobacterium)meningosepticum from the United Kingdom National Collection of Type Cultures and in one recent clinical isolate were investigated. All the strains hydrolyzed imipenem, but their levels of resistance to carbapenems varied, with imipenem and meropenem MICs ranging from 2 to >32 μg/ml. The blaB gene, which encodes a molecular-class B carbapenemase, was detected in only six reference strains and in clinical isolate 97/P/5448. The gene from 97/P/5448 had 98% nucleotide identity with the published se

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Lee, Kyungwon, Jong Back Lim, Jong Hwa Yum та ін. "bla VIM-2 Cassette-Containing Novel Integrons in Metallo-β-Lactamase-Producing Pseudomonas aeruginosa and Pseudomonas putida Isolates Disseminated in a Korean Hospital". Antimicrobial Agents and Chemotherapy 46, № 4 (2002): 1053–58. http://dx.doi.org/10.1128/aac.46.4.1053-1058.2002.

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ABSTRACT We investigated the phenotypic and genetic properties of metallo-β-lactamase-producing Pseudomonas isolates collected at a tertiary-care hospital in Korea since 1995. The prevalence of imipenem resistance among Pseudomonas aeruginosa isolates reached 16% in 1997, when 9% of the resistant organisms were found to produce VIM-2 β-lactamase, a class B enzyme previously found only in P. aeruginosa isolates from Europe. VIM-2-producing isolates of Pseudomonas putida were also detected. Resistance was transferable from both these species to P. aeruginosa PAO4089Rp by filter mating, although

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Sharma, Shubhangi, and Anshu Sharma. "Study of New Delhi Metallo Beta Lactamase and Oxacillinase beta Lactamase coexistence in Carbapenem Resistant Klebsiella Pneumoniae Obtained from Bloodstream Infections." International Journal of Health Sciences and Research 15, no. 1 (2025): 56–62. https://doi.org/10.52403/ijhsr.20250108.

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Background: Carbapenem‑resistant Klebsiella pneumoniae(CRkp) is of utmost clinical importance because they challenge the armamentarium of the treating clinicians, hampering current treatment strategies. This study aimed to compare the outcomes of oxacillinases β-lactamases (OXA-48) and New Delhi metallo-β-lactamase (NDM-1)-producing CRKP isolates, the two most common carbapenemases reported from Worldwide including India, obtained from patients with bloodstream infections in an ICU in a tertiary care center in southern part of Rajasthan and to compare the different laboratory methods for their

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Karampatakis, Theodoros, Katerina Tsergouli, and Payam Behzadi. "Carbapenem-Resistant Pseudomonas aeruginosa’s Resistome: Pan-Genomic Plasticity, the Impact of Transposable Elements and Jumping Genes." Antibiotics 14, no. 4 (2025): 353. https://doi.org/10.3390/antibiotics14040353.

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Pseudomonas aeruginosa, a Gram-negative, motile bacterium, may cause significant infections in both community and hospital settings, leading to substantial morbidity and mortality. This opportunistic pathogen can thrive in various environments, making it a public health concern worldwide. P. aeruginosa’s genomic pool is highly dynamic and diverse, with a pan-genome size ranging from 5.5 to 7.76 Mbp. This versatility arises from its ability to acquire genes through horizontal gene transfer (HGT) via different genetic elements (GEs), such as mobile genetic elements (MGEs). These MGEs, collective

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Aghamiri, Samira, Nour Amirmozafari, Jalil Fallah Mehrabadi, Babak Fouladtan, and Hossein Samadi Kafil. "Antibiotic Resistance Pattern and Evaluation of Metallo-Beta Lactamase Genes Including bla-IMP and bla-VIM Types in Pseudomonas aeruginosa Isolated from Patients in Tehran Hospitals." ISRN Microbiology 2014 (April 23, 2014): 1–6. http://dx.doi.org/10.1155/2014/941507.

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Beta-lactamase producing strains of Pseudomonas aeruginosa are important etiological agents of hospital infections. Carbapenems are among the most effective antibiotics used against Pseudomonas infections, but they can be rendered infective by group B β-lactamase, commonly called metallo-beta lactamase. In this study, the antimicrobial sensitivity patterns of P. aeruginosa strains isolated from 9 different hospitals in Tehran, Iran, as well as the prevalence of MBLs genes (bla-VIM and bla-IMP) were determined. A total of 212 strains of P. aeruginosa recovered from patients in hospitals in Tehr

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Toleman, Mark A., Kenneth Rolston, Ronald N. Jones та Timothy R. Walsh. "Molecular and Biochemical Characterization of OXA-45, an Extended-Spectrum Class 2d′ β-Lactamase in Pseudomonas aeruginosa". Antimicrobial Agents and Chemotherapy 47, № 9 (2003): 2859–63. http://dx.doi.org/10.1128/aac.47.9.2859-2863.2003.

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ABSTRACT As part of the CANCER Antimicrobial Surveillance Program in North America, a clinical strain of Pseudomonas aeruginosa, strain 07-406, isolated in Texas was found to be resistant to all antimicrobials except polymyxin B. Genetic analysis of this isolate identified two unique extended-spectrum β-lactamase genes. One, bla VIM-7, encoded a metallo-β-lactamase (unpublished data), and the other, bla OXA-45, described here, encoded a class D extended-spectrum β-lactamase. bla OXA-45 was isolated on a Sau3A1 genomic fragment of 1.8 kb and encodes a protein of 264 amino acids with the highest

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Furtado, Guilherme Henrique Campos, Ana Cristina Gales, Luciana Baria Perdiz, Anderson Fernandes Santos, and Eduardo Alexandrino Servolo de Medeiros. "Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa." Revista da Sociedade Brasileira de Medicina Tropical 44, no. 5 (2011): 604–6. http://dx.doi.org/10.1590/s0037-86822011000500015.

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INTRODUCTION: Pseudomonas aeruginosa is a leading cause of ventilator-associated pneumonia (VAP) and exhibits high rates of resistance to several antimicrobial drugs. The carbapenens are usually the drugs of choice against this microorganism. However, the carbapenem resistance has increased among these strains worldwide. The presence of metallo-β-lactamases (MBL) has been pointed out as a major mechanism of resistance among these strains. No previous study addressed outcomes of respiratory infections caused by these strains. METHODS: Our group sought to analyze the epidemiology and clinical ou

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Kato, Naoki, Kikuo Yamazoe, Chang-Gyun Han, and Eiichi Ohtsubo. "New Insertion Sequence Elements in the Upstream Region of cfiA in Imipenem-Resistant Bacteroides fragilis Strains." Antimicrobial Agents and Chemotherapy 47, no. 3 (2003): 979–85. http://dx.doi.org/10.1128/aac.47.3.979-985.2003.

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ABSTRACT The 747-bp cfiA gene, which encodes a metallo-β-lactamase, and the regions flanking cfiA in six imipenem-resistant and four imipenem-susceptible Bacteroides fragilis strains isolated in Japan were analyzed by PCR and DNA sequencing. The nucleotide sequences of the cfiA genes (designated cfiA1 to cfiA10 ) of all 10 strains tested varied from that of the standard cfiA gene from B. fragilis TAL2480. However, putative proteins encoded by the cfiA variants contained conserved amino acid residues important for zinc binding and hairpin loop formation, suggesting that cfiA variants have the c

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Biedenbach, D., S. Bouchillon, M. Hackel та ін. "Dissemination of NDM Metallo-β-Lactamase Genes among Clinical Isolates of Enterobacteriaceae Collected during the SMART Global Surveillance Study from 2008 to 2012". Antimicrobial Agents and Chemotherapy 59, № 2 (2014): 826–30. http://dx.doi.org/10.1128/aac.03938-14.

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ABSTRACTThe prevalence of carbapenemase enzymes continues to increase. Among the Ambler class B enzymes is the New Delhi metallo-β-lactamase (NDM). This particular enzyme is capable of hydrolyzing nearly all β-lactam antimicrobial agents and has spread rapidly, becoming a global problem. Therapeutic treatment options for patients infected with isolates which produce this enzyme are difficult to manage, as cross-resistance to other antimicrobial classes is common. The Study for Monitoring Antimicrobial Resistance Trends (SMART) is a global surveillance study evaluating the antimicrobial suscept

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Bayanbek, D. S., A. Bekbaeva, S. S. Kozhahmetova, B. R. Turdalina, and E. V. Zholdybaeva. "STUDY OF GENE EXPRESSION IN RESPONSE TO SERIAL EXPOSURE TO MEROPENEM IN BACTEROIDES FRAGILIS." Eurasian Journal of Applied Biotechnology, no. 1 (April 2, 2025): 10–20. https://doi.org/10.11134/btp.1.2025.2.

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Antibiotic resistance is a major global health concern, and inappropriate antibiotic use contributes significantly to the development of resistance in pathogens. Bacteroides fragilis, an anaerobic bacterium, is commonly treated with β-lactam antibiotics like meropenem. B. fragilis possesses various antibiotic resistance mechanisms, including enzymatic modification of antibiotics, efflux systems, and reduction of cell membrane permeability. The primary mechanism of carbapenem resistance in B. fragilis is linked to the production of a metallo-β-lactamase encoded by the cfiA gene. However, this g

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Valdezate, Sylvia, Fernando Cobo, Sara Monzón, et al. "Genomic Background and Phylogeny of cfiA-Positive Bacteroides fragilis Strains Resistant to Meropenem-EDTA." Antibiotics 10, no. 3 (2021): 304. http://dx.doi.org/10.3390/antibiotics10030304.

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Background: Bacteroides fragilis shows high antimicrobial resistance (AMR) rates and possesses numerous AMR mechanisms. Its carbapenem-resistant strains (metallo-β-lactamase cfiA-positive) appear as an emergent, evolving clade. Methods: This work examines the genomes, taxonomy, and phylogenetic relationships with respect to other B. fragilis genomes of two B. fragilis strains (CNM20180471 and CNM20200206) resistant to meropenem+EDTA and other antimicrobial agents. Results: Both strains possessed cfiA genes (cfiA14b and the new cfiA28), along with other AMR mechanisms. The presence of other eff

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Bogiel, Tomasz, Małgorzata Prażyńska, Joanna Kwiecińska-Piróg, Agnieszka Mikucka, and Eugenia Gospodarek-Komkowska. "Carbapenem-Resistant Pseudomonas aeruginosa Strains-Distribution of the Essential Enzymatic Virulence Factors Genes." Antibiotics 10, no. 1 (2020): 8. http://dx.doi.org/10.3390/antibiotics10010008.

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Pseudomonas aeruginosa is one of the most commonly isolated bacteria from clinical specimens, with increasing isolation frequency in nosocomial infections. Herein, we investigated whether antimicrobial-resistant P. aeruginosa strains, e.g., metallo-beta-lactamase (MBL)-producing isolates, may possess a reduced number of virulence genes, resulting from appropriate genome management to adapt to a changing hospital environment. Hospital conditions, such as selective pressure, may lead to the replacement of virulence genes by antimicrobial resistance genes that are crucial to survive under current

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Yong, Dongeun, Mark A. Toleman, Jan Bell та ін. "Genetic and Biochemical Characterization of an Acquired Subgroup B3 Metallo-β-Lactamase Gene,blaAIM-1, and Its Unique Genetic Context in Pseudomonas aeruginosa from Australia". Antimicrobial Agents and Chemotherapy 56, № 12 (2012): 6154–59. http://dx.doi.org/10.1128/aac.05654-11.

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ABSTRACTThree clinicalPseudomonas aeruginosaisolates (WCH2677, WCH2813, and WCH2837) isolated from the Women's and Children's Hospital, Adelaide, Australia, produced a metallo-β-lactamase (MBL)-positive Etest result. All isolates were PCR negative for known MBL genes. A gene bank was created, and an MBL gene, designatedblaAIM-1, was cloned and fully characterized. The encoded enzyme, AIM-1, is a group B3 MBL that has the highest level of identity to THIN-B and L1. It is chromosomal and flanked by two copies (one intact and one truncated) of an ISCRelement, ISCR15. Southern hybridization studie

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Lukić-Grlić, Amarela, Matea Kos, Marta Žižek, et al. "Emergence of Carbapenem-Hydrolyzing Oxacillinases in Acinetobacter baumannii in Children from Croatia." Chemotherapy 64, no. 4 (2019): 167–72. http://dx.doi.org/10.1159/000503746.

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Introduction: Carbapenem resistance in Acinetobacter baumannii can be mediated by carbapenemases of class A, class B metallo-β-lactamases (MBLs), and class D carbapenem-hydrolyzing oxacillinases (CHDL). The aim of the study was to investigate the antimicrobial susceptibility and β-lactamase production of carbapenem-resistant A. baumannii isolates (CRAB) from the Children’s Hospital Zagreb, Croatia. Methods: A total of 12 A. baumannii isolates collected between August 2016 and March 2018 were analyzed. Antibiotic susceptibility was determined by the broth microdilution method. The presence of M

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Ishiai, Masamichi, Masayo Kimura, Keiko Namikoshi, et al. "DNA Cross-Link Repair Protein SNM1A Interacts with PIAS1 in Nuclear Focus Formation." Molecular and Cellular Biology 24, no. 24 (2004): 10733–41. http://dx.doi.org/10.1128/mcb.24.24.10733-10741.2004.

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ABSTRACT The yeast SNM1/PSO2 gene specifically functions in DNA interstrand cross-link (ICL) repair, and its role has been suggested to be separate from other DNA repair pathways. In vertebrates, there are three homologs of SNM1 (SNM1A, SNM1B, and SNM1C/Artemis; SNM1 family proteins) whose functions are largely unknown. We disrupted each of the SNM1 family genes in the chicken B-cell line DT40. Both SNM1A- and SNM1B-deficient cells were sensitive to cisplatin but not to X-rays, whereas SNM1C/Artemis-deficient cells exhibited sensitivity to X-rays but not to cisplatin. SNM1A was nonepistatic wi

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Bansal, Madhulika, Anita Pandey, Kalpana Chauhan, and Peetam Singh. "Molecular characterization of carbapenemase production in clinical isolates of Klebsiella species isolated in a tertiary care hospital." Biomedicine 43, no. 6 (2024): 1813–16. http://dx.doi.org/10.51248/.v43i6.2515.

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Introduction and Aim: Emergence of resistance to carbapenems in clinical isolates of Klebsiella species is a matter of concern. This prospective study was carried out to determine the prevalence of carbapenem resistance in clinical isolates of Klebsiella species phenotypically and to confirm for the presence of bla NDM (New Delhi metallo-b-lactamase) and bla KPC (Klebsiella pneumoniae carbapenemase) genes in these isolates. Materials and Methods: The 336 clinical isolates of Klebsiella species were tested for carbapenemase production by phenotypic tests; the Modified Hodge Test (MHT) and Combi

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Mojica, Maria F., Joseph Rutter, Magdalena A. Taracila та ін. "1437. Biochemical characterization of L1 and L2 β-lactamases from clinical isolates of Stenotrophomonas maltophilia". Open Forum Infectious Diseases 7, Supplement_1 (2020): S723. http://dx.doi.org/10.1093/ofid/ofaa439.1618.

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Abstract Background Stenotrophomonas maltophilia is a Gram-negative, non-fermenting opportunistic pathogen. Two β-lactamases provide intrinsic resistance to β-lactams: a class B Metallo- β-lactamase L1, and a class A serine β-lactamase (SβL) L2. Recently, we described novel variants of the L1 and L2 in a collection of clinical S. maltophilia isolates collected in the US, and showed through analyses of the amino acid sequences that L1 and L2 grouped into 4 (A-D, B, C, and E) and 2 (A and D) clades, respectively. We aimed to characterize the new L1 and L2 clinical variants biochemically. Methods

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Yamano, Yoshinori, Miki Takemura, Krystyna Kazmierczak та ін. "1452. Molecular Profile of β-Lactamase Genes and Siderophore-Dependent Iron Transporter Genes of Cefiderocol High MIC Isolates from SIDERO-WT Studies". Open Forum Infectious Diseases 7, Supplement_1 (2020): S728—S729. http://dx.doi.org/10.1093/ofid/ofaa439.1633.

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Abstract Background Cefiderocol (CFDC) is a novel siderophore cephalosporin with efficacy against Gram-negative (GN) bacteria, including carbapenem-resistant Enterobacterales and non-glucose-fermenters such as Pseudomonas aeruginosa and Acinetobacter baumannii. In consecutive multinational surveillance (SIDERO-WT) studies (2014–2017), CFDC demonstrated activity with minimum inhibitory concentrations (MICs) of ≤4 mg/mL against 99.4% of 28,629 GN clinical isolates. We conducted molecular characterization of 161 isolates with CFDC MICs &gt;4 mg/mL from the SIDERO-WT studies. Methods A total o

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Simner, Patricia J., Belita N. A. Opene, Krizia K. Chambers, Matthew E. Naumann, Karen C. Carroll, and Pranita D. Tamma. "Carbapenemase Detection among Carbapenem-Resistant Glucose-Nonfermenting Gram-Negative Bacilli." Journal of Clinical Microbiology 55, no. 9 (2017): 2858–64. http://dx.doi.org/10.1128/jcm.00775-17.

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ABSTRACT Accurate detection of carbapenemase-producing glucose-nonfermenting Gram-negative bacilli (CPNFs), including Pseudomonas aeruginosa and Acinetobacter baumannii , is necessary to prevent their dissemination within health care settings. We performed a method comparison study of 11 phenotypic carbapenemase detection assays to evaluate their accuracy for the detection of CPNFs. A total of 96 carbapenem-resistant glucose-nonfermenting isolates were included, of which 29% produced carbapenemases. All CPNFs were molecularly characterized to identify β-lactamase genes. A total of 86% of the c

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Nawal Haji Mahmood and Azad Al-Brefkani. "Molecular Characterisation of Carbapenemase-Producing Acinetobacter baumannii isolates from Hospitalised Patients in Iraq." Journal of Life and Bio Sciences Research 3, no. 02 (2022): 27–32. http://dx.doi.org/10.38094/jlbsr30261.

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Carbapenem-resistant Acinetobacter baumannii has been considered one of the major threats to patients worldwide. To evaluate carbapenemase in several clinical isolates using phenotypic and genotypic approaches. A total of 49 A. baumannii isolates were tested against imipenem and meropenem discs on Muller Hinton agar, then screened phenotypically through the modified Hodge test (MHT), combined disc test (CDT) and modified carbapenem inactivation method (mCIM). The tested isolates have been subjected to polymerase chain reaction (PCR) detection to identify some carbapenemase-encoding genes and o

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Tozluyur, Abdullah. "Fosfomycin in the treatment of New Delhi Metallo-β-Lactamase-5 (blaNDM-5)-producing Escherichia coli infection". German Journal of Microbiology 4, № 1 (2024): 1–5. http://dx.doi.org/10.51585/gjm.2024.1.0028.

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The worldwide spread of Gram-negative bacteria showing pan-drug resistance raises significant concerns. The World Health Organization (WHO) designated carbapenem-resistant Enterobacteriaceae (CRE) as a critical priority on the global pathogen list in 2017. This issue has captured increased attention to research in the field of antimicrobial resistance, specifically concentrating on the discovery of novel antibiotics. The primary mechanism of carbapenem resistance revolves around the production of acquired carbapenemase, including class A Klebsiella pneumoniae carbapenem-resistant (KPC), class

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Thunyaharn, Sudaluck, Nichatorn Sungsirin, Anchalee Seeta, et al. "Fecal Colonization Rate of Carbapenem-resistant Enterobacterales among Volunteers in a Community of Raroeng Subdistrict, Wang Nam Khiao District, Nakhon Ratchasima Province, Thailand." Progress in Applied Science and Technology 14, no. 3 (2024): 1–10. https://doi.org/10.60101/past.2024.254703.

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Carbapenem-resistant Enterobacterales (CRE) have emerged as an important global public health problem due to their ability to cause high morbidity and mortality rates. CRE have the potential to spread not only in hospital settings but also in the community. Based on our knowledge, no investigation has been conducted of CRE presence among people in Raroeng Subdistrict, Wang Nam Khiao District, Nakhon Ratchasima Province, Thailand. This study aimed to clarify the CRE colonization status among volunteers in the community. This cross-sectional study was conducted in March 2023. A total of 121 feca

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Li, Hongyang, Mark A. Toleman, Peter M. Bennett, Ronald N. Jones та Timothy R. Walsh. "Complete Sequence of p07-406, a 24,179-Base-Pair Plasmid Harboring the blaVIM-7 Metallo-β-Lactamase Gene in a Pseudomonas aeruginosa Isolate from the United States". Antimicrobial Agents and Chemotherapy 52, № 9 (2008): 3099–105. http://dx.doi.org/10.1128/aac.01093-07.

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ABSTRACT An outbreak involving a Pseudomonas aeruginosa strain that was resistant to all tested antimicrobials except polymyxin B occurred in a hospital in Houston, TX. Previous studies on this strain showed that it possesses a novel mobile metallo-β-lactamase (MBL) gene, designated bla VIM-7, located on a plasmid (p07-406). Here, we report the complete sequence, annotation, and functional characterization of this plasmid. p07-406 is 24,179 bp in length, and 29 open reading frames were identified related to known or putatively recognized proteins. Analysis of this plasmid showed it to be compr

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Alnimr, Amani M. "Predictive role of culture-based MIC testing vs. genotyping for carbapenem-resistant Enterobacterales in a non-universal screening, highly resourced setting." Electronic Journal of General Medicine 20, no. 4 (2023): em495. http://dx.doi.org/10.29333/ejgm/13181.

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A lack of evidence of accuracy for various testing modalities for carbapenem-resistant Enterobacterales (CRE) reduces the efficiency of screening and delays the isolation of carriers. This study examined the performance of phenotypic detection of CRE in comparison to molecular testing. A cross-sectional study was conducted in an academic medical institution in Saudi Arabia on CRE-screened patients during a 36-month period (April 1, 2019, through March 31, 2022). Cases were followed up for their susceptibility status by the phenotypic gradient method and genotypes. Of 3,116 samples tested, 359

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Hermes, Djuli M., Caroline Pormann Pitt, Larissa Lutz, et al. "Evaluation of heteroresistance to polymyxin B among carbapenem-susceptible and -resistant Pseudomonas aeruginosa." Journal of Medical Microbiology 62, no. 8 (2013): 1184–89. http://dx.doi.org/10.1099/jmm.0.059220-0.

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One hundred and twenty-four Pseudomonas aeruginosa isolates were selected for antimicrobial susceptibility testing with anti-pseudomonal agents, MIC determination for polymyxin B and metallo-beta-lactamase detection (genes bla SPM, bla VIM-1, bla NDM-1 and bla IMP). According to the imipenem and/or meropenem susceptibility profile, a set of randomly selected isolates (12 isolates carbapenem-susceptible and 12 isolates carbapenem-resistant) were evaluated for heteroresistance to polymyxin B. Heteroresistance testing was performed by plating the isolates onto increasing concentrations of polymyx

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Russkih, A. A., N. V. Luk'janenko, A. V. Rudenko, A. A. Kolomiets, A. A. Petrova, and Y. V. Mikhailova. "Preliminary results of a study based on genome-wide sequencing of resistant K.pneumoniae strains in a multidisciplinary hospital in Barnaul." Medicina 11, no. 4 (2023): 42–54. http://dx.doi.org/10.29234/2308-9113-2023-11-4-42-54.

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Introduction. Klebsiella pneumoniae, one of the leading causative agents of nosocomial infections, is included in the group of so-called «ESKAPE» pathogens – microorganisms associated with increased antibiotic resistance, representing a serious problem for public health. K. pneumoniae is widespread and has a pronounced ability to acquire resistance to antimicrobial drugs. Inadequate antibacterial therapy in patients with nosocomial infections worsens the prognosis of the disease and increases hospital mortality, therefore, the prescribing of medications should be based on knowledge of the curr

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de Sousa, Telma, Michel Hébraud, Olimpia Alves, et al. "Study of Antimicrobial Resistance, Biofilm Formation, and Motility of Pseudomonas aeruginosa Derived from Urine Samples." Microorganisms 11, no. 5 (2023): 1345. http://dx.doi.org/10.3390/microorganisms11051345.

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Pseudomonas aeruginosa causes urinary tract infections associated with catheters by forming biofilms on the surface of indwelling catheters. Therefore, controlling the spread of the bacteria is crucial to preventing its transmission in hospitals and the environment. Thus, our objective was to determine the antibiotic susceptibility profiles of twenty-five P. aeruginosa isolates from UTIs at the Medical Center of Trás-os-Montes and Alto Douro (CHTMAD). Biofilm formation and motility are also virulence factors studied in this work. Out of the twenty-five P. aeruginosa isolates, 16% exhibited mul

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VonBank, Brittany, Sean O’Malley, Paula Snippes Vagnone та ін. "2462. Public Health Response to Contain the First Outbreak of New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae in Minnesota". Open Forum Infectious Diseases 6, Supplement_2 (2019): S852. http://dx.doi.org/10.1093/ofid/ofz360.2140.

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Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) producing the New Delhi-metallo-β-lactamase (NDM) carbapenemase are uncommon in the United States but are a serious threat for untreatable antibiotic-resistant infections. In Minnesota (MN), NDM-CRE is typically associated with receipt of healthcare abroad. We describe the public health response to contain the first outbreak of NDM-CRE in MN. Methods CRE is reportable, with isolate submission to the MN Department of Health (MDH) for MALDI-TOF identification, phenotypic carbapenemase production testing, and PCR for carbapenemase

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Lob, Sibylle, Krystyna Kazmierczak, Gregory Stone, and Daniel F. Sahm. "680. In vitro Activity of Ceftazidime–Avibactam and Comparator Agents Against Pseudomonas aeruginosa from ICU and Non-ICU Wards Collected in Latin America and Globally as Part of the ATLAS Surveillance Program 2016–2017." Open Forum Infectious Diseases 6, Supplement_2 (2019): S310. http://dx.doi.org/10.1093/ofid/ofz360.748.

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Abstract Background Ceftazidime–avibactam (CAZ-AVI) is a β-lactam/non-β-lactam β-lactamase inhibitor combination that can inhibit class A, C and some class D β-lactamases but not class B metallo-β-lactamases (MBLs). Antimicrobial resistance due to these β-lactamases and other mechanisms is increasing and is especially high in ICUs. This study evaluated the in vitro activity of CAZ-AVI and comparators against Pseudomonas aeruginosa isolates from patients in ICU and non-ICU wards. Methods Nonduplicate clinical isolates were collected in 2016–2017 in Asia/Pacific, Europe, Latin America, and Middl

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Kazmierczak, Krystyna, Gregory Stone, and Daniel F. Sahm. "693. In Vitro Activity of Ceftazidime–Avibactam and Comparator Agents Against Enterobacteriaceae and Pseudomonas aeruginosa Collected From Patients with Bloodstream Infections as Part of the ATLAS Global Surveillance Program, 2014–2017." Open Forum Infectious Diseases 6, Supplement_2 (2019): S314. http://dx.doi.org/10.1093/ofid/ofz360.761.

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Abstract Background Avibactam (AVI) is a β-lactamase inhibitor with potent inhibitory activity against Class A, Class C, and some Class D serine β-lactamases. The combination of ceftazidime (CAZ) with AVI has been approved in Europe and in the United States for several indications. This study evaluated the in vitro activity of CAZ-AVI and comparators against Enterobacteriaceae (Eba) and Pseudomonas aeruginosa (Pae) isolates collected from patients with bloodstream infections as part of the ATLAS surveillance program in 2014–2017. Methods A total of 53416 Eba and 15050 Pae nonduplicate clinical

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Kazmierczak, Krystyna, Boudewijn De Jonge, Gregory G. Stone, and Dan Sahm. "1372. In Vitro Activity of Novel Ceftazidime–Avibactam and Aztreonam–Avibactam Combinations Against Carbapenem-Nonsusceptible Enterobacteriaceae Isolates by Phenotype Collected in Latin America From 2014 to 2017 as Part of the INFORM Surveillance Program." Open Forum Infectious Diseases 5, suppl_1 (2018): S420. http://dx.doi.org/10.1093/ofid/ofy210.1203.

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Abstract Background Carbapenem-nonsusceptible Enterobacteriaceae (CRE) are often multidrug-resistant and infections caused by these organisms are associated with increased morbidity and mortality. The combination of avibactam (AVI), a non-β-lactam/β-lactamase inhibitor of Class A, C, and some D serine β-lactamases, with ceftazidime (CAZ) and aztreonam (ATM) is being developed to treat infections caused by CRE. CAZ-AVI reveals potent in vitro activity against CRE, except those producing metallo-β-lactamases (MBLs), whereas ATM-AVI inhibits growth of both MBL-positive and MBL-negative CRE. We ev

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Hackel, Meredith, Mark G. G. Wise, and Daniel F. Sahm. "1253. Antimicrobial Activity of Cefepime in Combination with Taniborbactam Against Clinical Isolates of Enterobacterales from 2018-2020 Global Surveillance." Open Forum Infectious Diseases 8, Supplement_1 (2021): S715. http://dx.doi.org/10.1093/ofid/ofab466.1445.

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Abstract Background Taniborbactam (formerly VNRX-5133) is a novel cyclic boronate-based broad-spectrum β-lactamase inhibitor with potent and selective direct inhibitory activity against both serine- and metallo-β-lactamases (Ambler Classes A, B, C and D). Taniborbactam restores the activity of cefepime against many difficult to treat organisms, including cephalosporin- and carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa. The activity of the investigational combination cefepime-taniborbactam (FTB) and comparator agents was evaluated against clinical isolates of Enterobacterales

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Bedenić, Branka, Mladen Pospišil, Marina Nađ та Daniela Bandić Pavlović. "Evolution of β-Lactam Antibiotic Resistance in Proteus Species: From Extended-Spectrum and Plasmid-Mediated AmpC β-Lactamases to Carbapenemases". Microorganisms 13, № 3 (2025): 508. https://doi.org/10.3390/microorganisms13030508.

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The management of infectious diseases has proven to be a daunting task for clinicians worldwide, and the rapid development of antibiotic resistance among Gram-negative bacteria is making it even more challenging. The first-line therapy is empirical, and it most often comprises β-lactam antibiotics. Among Gram-negative bacteria, Proteus mirabilis, an important community and hospital pathogen associated primarily with urinary tract and wound infection, holds a special place. This review’s aim was to collate and examine recent studies investigating β-lactam resistance phenotypes and mechanisms of

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Lob, Sibylle, Meredith Hackel, Gregory Stone, and Daniel F. Sahm. "1263. In Vitro Activity of Ceftazidime-avibactam and Comparator Agents against Enterobacterales and Pseudomonas aeruginosa Collected from Patients with Bloodstream Infections as Part of the ATLAS Global Surveillance Program, 2017-2019." Open Forum Infectious Diseases 8, Supplement_1 (2021): S720. http://dx.doi.org/10.1093/ofid/ofab466.1455.

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Abstract Background Avibactam (AVI) is a β-lactamase inhibitor with potent inhibitory activity against Class A, Class C, and some Class D serine β-lactamases. The combination of ceftazidime (CAZ) with AVI has been approved in Europe and in the United States for several indications. This study evaluated the in vitro activity of CAZ-AVI and comparators against Enterobacterales (Eba) and Pseudomonas aeruginosa (Pae) isolates collected from patients with bloodstream infections as part of the ATLAS surveillance program in 2017-2019. Methods A total of 48193 Eba and 15376 Pae non-duplicate clinicall

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Lob, Sibylle, Krystyna Kazmierczak, Francis Arhin, and Daniel F. Sahm. "1231. In Vitro Activity of Aztreonam-Avibactam and Comparator Agents Against Enterobacterales from Patients with Lower Respiratory Tract Infections Collected During the ATLAS Global Surveillance Program, 2017-2019." Open Forum Infectious Diseases 8, Supplement_1 (2021): S705. http://dx.doi.org/10.1093/ofid/ofab466.1423.

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Abstract Background β-lactamase-producing Enterobacterales (Ebact) frequently co-carry resistance to antimicrobials from other classes, limiting treatment options. Avibactam (AVI) inhibits class A, class C, and some class D serine β-lactamases, while aztreonam (ATM) is refractory to hydrolysis by class B metallo-β-lactamases (MBLs). ATM-AVI is being developed for use against drug-resistant isolates of Ebact, especially those co-producing MBLs and serine β-lactamases. This study evaluated the in vitro activity of ATM-AVI and comparators against Ebact collected in 2017-2019 from patients with lo

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Kazmierczak, Krystyna, Sibylle Lob, Greg Stone, and Daniel F. Sahm. "1569. In Vitro Activity of Ceftazidime-avibactam and Comparator Agents against Enterobacterales and Pseudomonas aeruginosa Collected from Patients with Bloodstream Infections as Part of the ATLAS Global Surveillance Program, 2015-2018." Open Forum Infectious Diseases 7, Supplement_1 (2020): S783—S784. http://dx.doi.org/10.1093/ofid/ofaa439.1749.

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Abstract Background Avibactam (AVI) is a β-lactamase inhibitor with potent inhibitory activity against Class A, Class C, and some Class D serine β-lactamases. The combination of ceftazidime (CAZ) with AVI has been approved in Europe and in the United States for several indications. This study evaluated the in vitro activity of CAZ-AVI and comparators against Enterobacterales (Eba) and Pseudomonas aeruginosa (Pae) isolates collected from patients with bloodstream infections as part of the ATLAS surveillance program in 2015-2018. Methods A total of 57048 Eba and 15813 Pae non-duplicate clinicall

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Skachkova, T. S., E. V. Kniazeva, E. N. Goloveshkina, et al. "The Prevalence of Genetic Determinants of Antibiotic Resistance, which are of Particular Epidemiological Consequences, in the Microbiota of the Oropharyngeal Swabs in Patients with Cystic Fibrosis." Epidemiology and Vaccinal Prevention 22, no. 4 (2023): 44–48. http://dx.doi.org/10.31631/2073-3046-2023-22-4-44-48.

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Relevance. Antibiotic resistance of microorganisms can contribute to the chronicity of the inflammatory process, lead to an increase in the cost of treating patients and make it difficult to eradicate the pathogen. Patients with cystic fibrosis constantly require medical supervision, regular visits to medical institutions, and therefore there is a high risk of infection with nosocomial antibiotic- resistant strains. In addition, the necessary intake of antibacterial drugs provides an advantage for the reproduction of resistant microorganisms.Aim. Comparison of the frequency of detection of ant

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Castanheira, Mariana, Jill Lindley, Timothy B. Doyle, Andrew P. Davis та Olga Lomovskaya. "166. Activity of a Novel β-lactamase Inhibitor QPX7728 Combined With β-lactams Against st258 klebsiella Pneumoniae and st131 escherchia Coli Isolates Producing β-lactamases". Open Forum Infectious Diseases 7, Supplement_1 (2020): S212—S213. http://dx.doi.org/10.1093/ofid/ofaa439.476.

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Abstract Background ST258 K. pneumoniae and ST131 E. coli clones are considered vectors for the global spread of multidrug resistance. We evaluated the activity of β-lactams in combination with QPX7728, a novel β-lactamase inhibitor active against all β-lactamase classes, against a collection of 210 isolates belonging to these clones collected from a worldwide surveillance study. Methods A total of 118 ST258 K. pneumoniae and 92 ST131 E. coli (single loci variant also included) were susceptibility tested by reference broth microdilution against various β-lactams ± QPX7728 and comparator agents

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Adelman, Max W., Chris W. Bower, Julian E. Grass, et al. "177. Distinctive Features of Ertapenem Mono-Resistant Carbapenem-Resistant Enterobacterales in the United States: A Cohort Study." Open Forum Infectious Diseases 8, Supplement_1 (2021): S108—S109. http://dx.doi.org/10.1093/ofid/ofab466.177.

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Abstract Background Carbapenem-resistant Enterobacterales (CRE) are highly antibiotic-resistant bacteria. Whether CRE resistant only to ertapenem among carbapenems (ertapenem mono-resistant) represent a unique CRE subset with regards to risk factors, carbapenemase genes, and outcomes is unknown. Methods We analyzed laboratory- and population-based surveillance data from nine sites participating in CDC’s Emerging Infections Program (EIP). We defined an incident case as the first isolation of Enterobacter cloacae complex, Escherichia coli, Klebsiella aerogenes, K. oxytoca, K. pneumoniae, or K. v

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Heydari, Farzad, Fatih Koksal, Cansu Önlen Güneri та Suna Kizilyildirim. "Molecular analysis of metallo-β-lactamase genes in some gram-negative bacteria and examination of the phylogenetic relationships of isolates". Journal of Clinical Medicine of Kazakhstan 19, № 6 (2022): 18–26. http://dx.doi.org/10.23950/jcmk/12648.

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<b>Aim:</b> This study aimed to determine the susceptibility of carbapenem-resistant Gr (-) bacilli isolated from various clinical infections to various antibiotics and identify genes causing carbapenem resistance and their clonal relationships to elucidate the distribution of resistance in community and/or hospital-acquired strains.<br /> <b>Material and methods:</b> In this study, antibiotic susceptibilities of 450 carbapenem-resistant Gr (-) bacilli isolated from clinical specimens at Cukurova University, Faculty of Medicine, Balcali Hospital, were investigated

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Akereuke, U. E., I. A. Onwuezobe, A. E. Ekuma та ін. "Molecular Profile of Metallo-β-Lactamase Producing Bacterial Isolates from Clinical Samples; South-South Nigeria Perspective". Mikrobiolohichnyi Zhurnal 85, № 6 (2023): 15–25. http://dx.doi.org/10.15407/microbiolj85.06.015.

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One of the major clinical problems regarding β-lactam antibiotics resistance is attributed to metallo-beta-lactamases (MβL), which are a group of enzymes that is a subset of beta- lactamases belonging to group B of the Ambler classification, which causes hydrolysis of carbapenems. The study was conducted to check the prevalence of MβL and its genes (IMP, VIM, and NDM) among Gram-negative isolates. Methods. 312 clinical samples (urine and wound) were cultured, and antimicrobial susceptibility testing was performed using the conventional disk diffusion method. MβL-phenotypic detection was uncove

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Mendes, Rodrigo E., Timothy B. Doyle, Dee Shortridge, et al. "1232. In Vitro Activity of Cefiderocol and Comparator Agents against Molecularly characterized Carbapenem-resistant Enterobacterales Clinical Isolates Causing Infection in United States Hospitals (2020)." Open Forum Infectious Diseases 8, Supplement_1 (2021): S705—S706. http://dx.doi.org/10.1093/ofid/ofab466.1424.

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Abstract Background Cefiderocol (CFDC) represents a new addition to the antimicrobial armamentarium with broad activity against Gram-negative bacteria (GNB). CFDC remains stable to hydrolysis in the presence of serine β-lactamases (ESBLs, KPC and OXA-type carbapenemases) and metallo-β-lactamases. The CFDC and comparator activities were analyzed against Enterobacterales (ENT), including molecularly characterized carbapenem-resistant isolates (CRE), as a part of the SENTRY Antimicrobial Surveillance Program in the USA. Methods 4,053 ENT were collected from 31 sites in 2020. Susceptibility testin

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