Relevant bibliographies by topics / Metalloproteinases Inhibitors Therapeutic use

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Metalloproteinases Inhibitors Therapeutic use'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Metalloproteinases Inhibitors Therapeutic use.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Metalloproteinases Inhibitors Therapeutic use"

1

Ganea, E., M. Trifan, A. C. Laslo, G. Putina, and C. Cristescu. "Matrix metalloproteinases: useful and deleterious." Biochemical Society Transactions 35, no. 4 (July 20, 2007): 689–91. http://dx.doi.org/10.1042/bst0350689.

Full text
Abstract:
MMPs (matrix metalloproteinases) are zinc-dependent endopeptidases that degrade both matrix and non-matrix proteins. They play an important role in morphogenesis, and in a wide range of processes including tissue repair and remodelling. Their abnormal expression contributes to pathological processes including arthritis, cancer, and cardiac and central nervous system diseases, which explains the large interest in finding specific MMP inhibitors for therapeutic use. In this review we describe the structural features of MMPs, with special emphasis on their interaction with specific inhibitors. Th
APA, Harvard, Vancouver, ISO, and other styles
2

Jakubowska, Katarzyna, Anna Pryczynicz, Piotr Iwanowicz, Andrzej Niewiński, Elżbieta Maciorkowska, Jerzy Hapanowicz, Dorota Jagodzińska, Andrzej Kemona, and Katarzyna Guzińska-Ustymowicz. "Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases." Gastroenterology Research and Practice 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2456179.

Full text
Abstract:
Crohn’s disease (CD) and ulcerative colitis (UC) belong to a group of inflammatory bowel diseases (IBD). The aim of our study was to evaluate the expression of MMP-2, MMP-7, MMP-9, TIMP-1, and TIMP-2 in ulcerative colitis and Crohn’s disease. The study group comprised 34 patients with UC and 10 patients with CD. Evaluation of MMP-2, MMP-7, MMP-9, TIMP-1, and TIMP-2 expression in tissue samples was performed using immunohistochemistry. The overexpression of MMP-9 and TIMP-1 was dominant in both the glandular epithelium and inflammatory infiltration in UC patients. In contrast, in CD subjects th
APA, Harvard, Vancouver, ISO, and other styles
3

De, S., J. E. Fenton, and A. S. Jones. "Matrix metalloproteinases and their inhibitors in non-neoplastic otorhinolaryngological disease." Journal of Laryngology & Otology 119, no. 6 (June 2005): 436–42. http://dx.doi.org/10.1258/0022215054273269.

Full text
Abstract:
Matrix metalloproteinases (MMPs) are a family of zinc and calcium-dependent endopeptidases that play a key role in extracellular matrix (ECM) degradation. MMPs are known to be important in normal remodelling processes. Overexpression and activation of MMPs or an imbalance of active MMPs and tissue inhibitors of metalloproteinases (TIMPs) has been linked with a number of specific disease states associated with the breakdown and remodelling of the extracellular matrix. MMPs and TIMPs play a role in the development and progression of conditions such as acute and chronic otitis media, nasal polypo
APA, Harvard, Vancouver, ISO, and other styles
4

Titovska, S. O. "EFFECTIVENESS OF MATRIX METALLOPROTEINASES INHIBITORS FOR PREVENTIVE TREATMENT OF GENERALIZED PERIODONTITIS." Ukrainian Dental Almanac, no. 2 (June 27, 2022): 10–15. http://dx.doi.org/10.31718/2409-0255.2.2022.02.

Full text
Abstract:
Generalized periodontitis is one of the most widespread human stomatological diseases; it is diagnosed in 11.0 % of the world's population. Despite the recognition of the microbial factor as leading in its etiopathogenesis, antimicrobial treatment of gingivitis, added with removal of dental plaque, does not prevent the further development of periodontitis. Dysbacteriosis causes inflammation which leads to an increase of proteolysis products. They are a nutrient medium for periodontal pathogenic microflora, they contribute to its growth. So, the use of anti-inflammatory drugs, such as matrix me
APA, Harvard, Vancouver, ISO, and other styles
5

Beletskaya, Inessa Stanislavovna, and Sergey Yurievich Astakhov. "The role of matrix metalloproteinases in glaucoma pathogenesis." Ophthalmology journal 8, no. 3 (December 15, 2015): 28–43. http://dx.doi.org/10.17816/ov2015328-43.

Full text
Abstract:
Matrix metalloproteinases belong to an enzyme family, which assure a proteolysis of practically all components of the extracellular matrix of connective tissues in normal and pathological conditions. At physiological conditions, there are evidences on the impact of this enzyme group in the embryogenesis, morphogenesis, angiogenesis, and tissue involution. The activity impairment of matrix metalloproteinases and of their specific inhibitors leads to the biosynthesis misbalance and to the degradation of extracellular matrix components; it plays a role in the development of such diseases as diabe
APA, Harvard, Vancouver, ISO, and other styles
6

Docherty, Andy J., Tom Crabbe, James P. O'Connell, and Colin R. Groom. "Proteases as drug targets." Biochemical Society Symposia 70 (September 1, 2003): 147–61. http://dx.doi.org/10.1042/bss0700147.

Full text
Abstract:
The effective management of AIDS with HIV protease inhibitors, or the use of angiotensin-converting enzyme inhibitors to treat hypertension, indicates that proteases do make good drug targets. On the other hand, matrix metalloproteinase (MMP) inhibitors from several companies have failed in both cancer and rheumatoid arthritis clinical trials. Mindful of the MMP inhibitor experience, this chapter explores how tractable proteases are as drug targets from a chemistry perspective. It examines the recent success of other classes of drug for the treatment of rheumatoid arthritis, and highlights the
APA, Harvard, Vancouver, ISO, and other styles
7

Elgezawi, Moataz, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Wölfle, Yasir Siddiqui, and Dalia Kaisarly. "Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects." International Journal of Molecular Sciences 23, no. 16 (August 11, 2022): 8929. http://dx.doi.org/10.3390/ijms23168929.

Full text
Abstract:
Objectives: This review article aims to describe some of the roles of Matrix metalloproteinases (MMPs) in enamel, dentine, dental caries, hybrid layer degradation, pulp and periodontal tissues, throwing light on their current inhibitors. The article addresses the potential of MMPs to serve as biomarkers with diagnostic and therapeutic value. Design: The sections of this review discuss MMPs’ involvement in developmental, remodeling, degradational and turnover aspects of dental and periodontal tissues as well as their signals in the pathogenesis, progress of different lesions and wound healing o
APA, Harvard, Vancouver, ISO, and other styles
8

Doll, Carla U., Sabine Niebert, and Janina Burk. "Mesenchymal Stromal Cells Adapt to Chronic Tendon Disease Environment with an Initial Reduction in Matrix Remodeling." International Journal of Molecular Sciences 22, no. 23 (November 26, 2021): 12798. http://dx.doi.org/10.3390/ijms222312798.

Full text
Abstract:
Tendon lesions are common sporting injuries in humans and horses alike. The healing process of acute tendon lesions frequently results in fibrosis and chronic disease. In horses, local mesenchymal stromal cell (MSC) injection is an accepted therapeutic strategy with positive influence on acute lesions. Concerning the use of MSCs in chronic tendon disease, data are scarce but suggest less therapeutic benefit. However, it has been shown that MSCs can have a positive effect on fibrotic tissue. Therefore, we aimed to elucidate the interplay of MSCs and healthy or chronically diseased tendon matrix
APA, Harvard, Vancouver, ISO, and other styles
9

Cho, Chul-Hyun, Kwang-Soon Song, Beom-Soo Kim, Du Hwan Kim, and Yun-Mee Lho. "Biological Aspect of Pathophysiology for Frozen Shoulder." BioMed Research International 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/7274517.

Full text
Abstract:
It is fairly well understood that frozen shoulder involves several stages, which reflect the series of process from capsular inflammation and fibrosis to spontaneous resolution of this fibrosis. However, the underlying pathophysiologic process remains poorly determined. For this reason, management of frozen shoulder remains controversial. Determining the pathophysiological processes of frozen shoulder is a pivotal milestone in the development of novel treatment for patients with frozen shoulder. This article reviews what is known to date about the biological pathophysiology of frozen shoulder.
APA, Harvard, Vancouver, ISO, and other styles
10

Laghezza, Antonio, Luca Piemontese, Leonardo Brunetti, Alessia Caradonna, Mariangela Agamennone, Fulvio Loiodice, and Paolo Tortorella. "(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone." Pharmaceuticals 14, no. 2 (January 24, 2021): 85. http://dx.doi.org/10.3390/ph14020085.

Full text
Abstract:
Matrix Metalloproteinases (MMPs) are a family of secreted and membrane-bound enzymes, of which 24 isoforms are known in humans. These enzymes degrade the proteins of the extracellular matrix and play a role of utmost importance in the physiological remodeling of all tissues. However, certain MMPs, such as MMP-2, -9, and -13, can be overexpressed in pathological states, including cancer and metastasis. Consequently, the development of MMP inhibitors (MMPIs) has been explored for a long time as a strategy to prevent and hinder metastatic growth, but the important side effects linked to promiscuo
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Metalloproteinases Inhibitors Therapeutic use"

1

Tang, Wing-yan, and 鄧詠欣. "Curcumin inhibits cancer cells migration and invasion of tongue carcinoma through down-regulation of matrix metalloproteinase-10." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47869768.

Full text
Abstract:
 Squamous cell carcinoma of the tongue has a low survival rate, with cure rate reduced by half if cervical lymph node metastasis is present. Standard treatment regimen includes surgical resection of the tumor, radiotherapy and chemotherapy. These treatment modalities, however, can result in irreversible side effects including loss of form and function of the tongue. So far, there is no efficient treatment regime targeting migration and invasion of tongue carcinoma. Curcumin is a natural polyphenol extracted from Curcuma longa. Recent studies indicated that curcumin is a potential anti-can
APA, Harvard, Vancouver, ISO, and other styles
2

Roach, Denise Margaret. "Upregulation of matrix metalloproteinases -2 and -9 and type IV collagen degradation in skeletal muscle reperfusion injury." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09MD/09mdr6281.pdf.

Full text
Abstract:
Includes bibliographical references (leaves 292-352) Determines the role of matrix metalloproteinases, MMP-2 and MMP-9 in reperfusion injury following skeletal muscle ischaemia; and, whether inhibition of MMPs by doxycycline protects against tissue damage.
APA, Harvard, Vancouver, ISO, and other styles
3

Peng, Xiaofang, and 彭晓芳. "Naturally occurring inhibitors against the formation of advanced glycation endproducts." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44892706.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Sun, Wentao, and 孙文韬. "The effects of Panax notoginseng extracts and its components on TNF-alpha induced MMP-9 expression and activity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207686.

Full text
Abstract:
Matrix metalloproteinase (MMP) induced extra cellular matrix (ECM) degradation is a crucial process involved in the development of many chronic inflammatory diseases, including cardiac remodeling and cancer metastasis. In cardiac remodeling, the presence of pathological stimuli leads to elevated MMP-9 expression and impairment of cardiac performance, which subsequently develops into heart failure. While in tumorgenesis, MMP-9 has been found to play key roles in metastasis, as it can break physical barriers for the tumor. Therefore, searching for agents targeting MMP-9 is a new direction for th
APA, Harvard, Vancouver, ISO, and other styles
5

Chan, Hoi-ching, and 陳凱靜. "Heat shock protein 90 inhibitor 17-AAG potentiates anticancer activityof bortezomib in NK cell malignancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632025.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

He, Ru, and 何茹. "Effectiveness and toxicity of aromatase inhabitors [i.e. inhibitors] in adjuvant therapy for hormone receptor positive postmenopausalbreast cancer: a meta-analysis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46936026.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Gu, Baoying. "Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy : effects of nimesulide." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112627.

Full text
Abstract:
Wernicke's encephalopathy is a neuropsychiatric disorder resulting from thiamine deficiency (TD) and is characterized by neuronal loss, astrocytic proliferation and microglial activation. Cyclooxygenases (COX) are enzymes which catalyze the first step in the synthesis of prostanoids. COX-1 is expressed constitutively and COX-2 is the inducible isoform. Groups of TD rats and pair-fed controls were killed at presymptomatic and symptomatic stages of encephalopathy. Cresyl violet and NeuN staining showed decreased numbers of neuronal cells in vulnerable regions (medial thalamus and inferior collic
APA, Harvard, Vancouver, ISO, and other styles
8

Ho, Kwun-wai, and 何冠威. "Angiotensin converting enzyme inhibitor alone or in combination with angiotensin II type I receptor blocker in patients with chronicproteinuric nephropathies: a systemic reviewof clinical trials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010687.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Scrivens, Paul James. "Regulation and chemotherapeutic targeting of human Cdc25A phosphatase." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103293.

Full text
Abstract:
The Cdc25 phosphatases are highly conserved from yeast through humans and play pivotal roles in regulating the activities of cyclin-dependent kinases (Cdks). Cdc25A is one of three human Cdc25 family members, and has previously been shown to be overexpressed in numerous cancers and to transform rodent fibroblasts. Cdc25A therefore represents a rational target for chemotherapeutic development. Further, a thorough understanding of its biology and regulation in normal and transformed cells may facilitate the development of strategies to specifically interfere with the proliferation of cancerous c
APA, Harvard, Vancouver, ISO, and other styles
10

Wong, Carmen, and 黃嘉敏. "A systematic review of the drug sorafenib in extending survival time in patients with hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46942865.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Metalloproteinases Inhibitors Therapeutic use"

1

Rotheim, Philip. New developments in therapeutic enzyme inhibitors and receptor blockers. Norwalk, CT: Business Communications Co., 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Goudot-Perrot, Andrée. Metabolic inhibitors: Antibiotics - antimitotics - psychotropics. Stuttgart: Schwer Verlag, 1992.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Co, Business Communications. New developments in therapeutic enzyme inhibitors and blockers. Norealk, CT: Business Communications Co., 2002.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

George, Weinbaum, Giles Ralph E, Krell Robert D, New York Academy of Sciences., and American Thoracic Society, eds. Pulmonary emphysema: The rationale for therapeutic intervention. New York, N.Y: New York Academy of Sciences, 1991.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

PhD, Henderson Brian, and Bodmer Mark W, eds. Therapeutic modulation of cytokines. Boca Raton, Fla: CRC Press, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

K, Ghosh Arun. Aspartic acid proteases as therapeutic targets. Weinheim: Wiley-VCH, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

K, Ghosh Arun. Aspartic acid proteases as therapeutic targets. Weinheim: Wiley-VCH, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Philippe, Taupin, ed. The cystatin superfamily of proteinase inhibitors. New York: Nova Science Publishers, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Osiadacz, Jarosław. Inhibitory topoizomeraz DNA i ich zastosowanie w chemioterapii. Wrocław: Oficyna Wydawnicza Politechniki Wrocławskiej, 1999.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Li, William W. The antiangiogenic therapy self help book for cancer patients. Cambridge, Mass: Angiogenesis Foundation, 2003.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Metalloproteinases Inhibitors Therapeutic use"

1

Darby, Ian A., and Alexis Desmoulière. "Scar Formation: Cellular Mechanisms." In Textbook on Scar Management, 19–26. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_3.

Full text
Abstract:
AbstractFibroblasts are key players in the maintenance of skin homeostasis and in orchestrating physiological tissue repair. Fibroblasts secrete and are embedded in a sophisticated extracellular matrix, and a complex and interactive dialogue exists between fibroblasts and their microenvironment. In addition to the secretion of the extracellular matrix, fibroblasts and myofibroblasts secrete extracellular matrix remodeling enzymes, matrix metalloproteinases and their inhibitors, and tissue inhibitors of metalloproteinases and are thus able to remodel the extracellular matrix. Myofibroblasts and their microenvironment form a network that evolves during tissue repair. This network has reciprocal actions affecting cell differentiation, cell proliferation, cell quiescence, or apoptosis and has actions on growth factor bioavailability by binding, sequestration, and activation. Mechanical forces also play a role in regulating the myofibroblast phenotype as cells are subjected to mechanical stress and mechanical signaling is activated. Innervation is also involved in both skin repair processes and differentiation of myofibroblasts. In pathological situations, for example, in excessive scarring, the dialogue between myofibroblasts and their microenvironment can be altered or disrupted, leading to defects in tissue repair or to pathological scarring, such as that seen in hypertrophic scars. Better understanding of the intimate dialogue between myofibroblasts and their local microenvironment is needed and will be important in aiding the identification of new therapeutic targets and discovery of new drugs to treat or prevent aberrant tissue repair and scarring.
APA, Harvard, Vancouver, ISO, and other styles
2

Thiemermann, Christoph. "Combined Use of Nitric Oxide and Nitric Oxide Synthase Inhibitors as a Possible Therapeutic Approach." In Nitric Oxide in Pulmonary Processes: Role in Physiology and Pathophysiology of Lung Disease, 209–25. Basel: Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8474-7_12.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Jung, Jin G., and Anne Le. "Metabolism of Immune Cells in the Tumor Microenvironment." In The Heterogeneity of Cancer Metabolism, 173–85. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65768-0_13.

Full text
Abstract:
AbstractThe tumor microenvironment (TME) is a complex biological structure surrounding tumor cells and includes blood vessels, immune cells, fibroblasts, adipocytes, and extracellular matrix (ECM) [1, 2]. These heterogeneous surrounding structures provide nutrients, metabolites, and signaling molecules to provide a cancer-friendly environment. The metabolic interplay between immune cells and cancer cells in the TME is a key feature not only for understanding tumor biology but also for discovering cancer cells’ vulnerability. As cancer immunotherapy to treat cancer patients and the use of metabolomics technologies become more and more common [3], the importance of the interplay between cancer cells and immune cells in the TME is emerging with respect to not only cell-to-cell interactions but also metabolic pathways. This interaction between immune cells and cancer cells is a complex and dynamic process in which immune cells act as a determinant factor of cancer cells’ fate and vice versa. In this chapter, we provide an overview of the metabolic interplay between immune cells and cancer cells and discuss the therapeutic opportunities as a result of this interplay in order to define targets for cancer treatment. It is important to understand and identify therapeutic targets that interrupt this cancerpromoting relationship between cancer cells and the surrounding immune cells, allowing for maximum efficacy of immune checkpoint inhibitors as well as other genetic and cellular therapies.
APA, Harvard, Vancouver, ISO, and other styles
4

"Inhibitors of Matrix Metalloproteinases: Design, Structure and Therapeutic Applications." In Frontiers in Medicinal Chemistry - (Volume 1), edited by Jerry W. Skiles, Nina C. Gonnella, and Arco Y. Jeng, 29–75. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/978160805204210401010029.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

COURTNEY, M., S. JALLAT, D. CARVALLO, R. G. CRYSTAL, M. SCHAPIRA, and C. ROITSCH. "ANTIPROTEASE ENGINEERING: NEW PROTEASE INHIBITORS FOR THERAPEUTIC USE." In Protides of the Biological Fluids, 493–95. Elsevier, 1987. http://dx.doi.org/10.1016/b978-0-08-035588-7.50113-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Nevzorova, Vera, Tatiana Brodskaya, and Eugeny Gilifanov. "Smoking and COPD: Endothelium-Related and Neuro-mediated Emphysema Mechanisms." In Update in Respiratory Diseases. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.85927.

Full text
Abstract:
This chapter describes endothelium-related and neuro-mediated mechanisms of emphysema development in chronic obstructive pulmonary disease (COPD) and smoking on the basis of previously completed studies, literature data, and own researches. As components of neurogenic inflammation in the processes of tissue remodeling in emphysema, we describe the distribution and activity of the substance P, neurokinin-1 and its receptor, tissue metalloproteinases and their tissue inhibitors in the lungs during the entire experimental period, the modeling of COPD in rats with a smoking model. We also analyzed the content of neurokinin system markers, the localization, and markers of tissue metalloproteinases in human lung tissue structures. We have confidence that there is a special morphofunctional continuum of development of lower respiratory tract remodeling in response to chronic exposure to tobacco smoke and the development of inflammation in COPD. New data suggest that imbalance of neuro-mediated interactions, alteration of vasomotoric signaling mechanisms, secretion, mucociliary clearance, cytoprotection involving substance P-dependent components with impaired content, and development of dystopia of matrix metalloproteinases and their tissue inhibitors are involved in the initiation of morphological restructuring. Research in this direction should be continued to allow approaches to the development of preventive and therapeutic strategies for emphysema.
APA, Harvard, Vancouver, ISO, and other styles
7

Angeli, Andrea, and Claudiu T. Supuran. "Therapeutic Use of Carbonic Anhydrase Inhibitors and Their Multiple Drug Interactions." In Pharmaceutical Biocatalysis, 73–98. Jenny Stanford Publishing, 2019. http://dx.doi.org/10.1201/9780429295034-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Ma, Zetong, Wenyan Fu, Changhai Lei, and Shi Hu. "Use of MET kinase inhibitors to overcome cetuximab resistance in colorectal cancer." In Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies, 113–17. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-12-821584-5.00019-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Keeling, David. "Therapeutic anticoagulation." In Oxford Textbook of Medicine, edited by Jeremy Dwight, 3729–34. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0376.

Full text
Abstract:
The main indications for therapeutic anticoagulation are venous thromboembolism, deep vein thrombosis, and pulmonary embolism, and the prevention of stroke in patients with atrial fibrillation or mechanical heart valves. Low-molecular-weight heparins have largely replaced unfractionated heparin in its treatment. Their much more predictable anticoagulant response combined with high bioavailability after subcutaneous injection means that the dose can be calculated by body weight and given subcutaneously without any monitoring or dose adjustment. Their widespread use resulted in most patients with deep vein thrombosis being managed as outpatients, and this is also increasingly the case for uncomplicated pulmonary embolism. Oral direct inhibitors of anticoagulation that specifically target thrombin or factor Xa are increasingly used to treat acute venous thromboembolism and for stroke prevention in atrial fibrillation.
APA, Harvard, Vancouver, ISO, and other styles
10

Alayande, Kazeem A., Abdulwakeel A. Ajao, and Mariam O. Oyedeji- Amusa. "Bioactive Compounds as Therapeutic Intervention in Bacterial Infections." In Therapeutic Use of Plant Secondary Metabolites, 139–60. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815050622122010009.

Full text
Abstract:
This study highlights the significance of drug resistance towards difficultiesin the treatment of infectious diseases, the essence of bioactive compounds intherapeutic intervention, and the unique approach employed by bioactive compoundsaway from conventional synthetic drugs. Literature was gathered from different onlinedatabases to retrieve the required information. Bacterial resistance to antibiotics is amajor concern that threatens clinical efforts in treating bacterial infections. This hasgrossly reduced clinical success on previously curable infections and/or sometimesresults in a prolonged hospital stay. Antibiotics provide protection and remedy againstinfectious diseases. But the emergence of multi-drug resistance strains has inflicteduntold loss of effectiveness on virtually every conventional antibiotic. Hence, scientificcommunities are propelled into seeking alternative therapies in a bid to mitigate theoverwhelming consequence on public health. Bioactive molecules are importantsources of newly derived therapeutic agents. They have minimal likelihood of inducingunintended immune reactions, reduced level of toxicity; are structurally diverse innature, exhibit broad-spectrum therapeutic effects. Bioactive molecules are commonlypresent in small amounts in plant-based foods; and provide health benefits in additionto the basic nutritional values expected in foods. Several plant-based bioactiveprinciples serve as inhibitors for drug resistance in order to enhance the effectivedelivery of the antibacterial compounds. Meat products are a good source of non-plantbioactive molecules, which are expressed in the form of peptides, vitamins, mineralsand fatty acids. Other important sources include endophytic bacteria, endophytic fungi,probiotic bacteria, actinomycetes and marine organisms. Natural products are relatively safe when compared to their synthetic counterparts. As newly manufactured potentantibiotics become increasingly unavailable and/or unaffordable, bioactive compoundspresent viable alternatives. They are readily available and are derived from inexpensiveraw materials via cheap technology.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Metalloproteinases Inhibitors Therapeutic use"

1

Meng, Wilson S., Jeffrey R. Kovacs, and Ellen S. Gawalt. "The Use of Non-Viral Nucleic Acids Carriers for the Modulation of Leukocytes." In ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2008. http://dx.doi.org/10.1115/smasis2008-348.

Full text
Abstract:
Induction of drug-free permanent organ accommodation is the ultimate goal of transplant therapy. Current pharmacological agents, however, are non-specific in their actions and generally do not confer immunological tolerance. Inhibitors of T cell receptor signaling (tacrolimus and cyclosporine A) represent the mainstay in transplant management. These agents exert their therapeutic effects by dampening the activities of all T cells. Chronic exposure to these agents increases the risk of developing opportunistic infections and malignancies. Given that more than 20,000 Americans undergo organ tran
APA, Harvard, Vancouver, ISO, and other styles
2

Yalcin, Huseyin, Hissa Al-Thani, and Samar Shurbaji. "Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0088.

Full text
Abstract:
Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI that has been developed recently but not explored much is Ponatinib. The use of nanoparticles as a better therapeutic agent to deliver anti-cancer drugs and reduce their cardiotoxicity has been recently considered. In this study, PLGA-PEG-PLGA nanoparticles were synthesized to deliver Ponatinib while reducing its cardiotoxicity for treatment of chronic myeloid leukemia. Shape,
APA, Harvard, Vancouver, ISO, and other styles
3

Arora, Rahul D. "Definition, etiopathogenesis, management and role of flouroquinolone prophylaxis in prevention of spontaneous bacterial peritonitis complicating malignant ascites." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685345.

Full text
Abstract:
Background: Malignancy related ascites encompasses multiple etiologies which include peritoneal carcinomatosis, hepatic synthetic dysfunction due to parenchymal involvement by the tumour, transcoeloemic metastasis and chylous ascites due to lymphatic obstruction. Primary Cancer type, liver metastasis and serum albumin have been listed as independent prognostic markers in malignant ascites. Spontaneous Bacterial Peritonitis is usually seen as a complication of decompensated chronic liver disease due to translocation of bacteria or haematogenous dissemination from a distant focus of infection. T
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Metalloproteinases Inhibitors Therapeutic use' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography