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Relevant bibliographies by topics / Metals in surgery - Biocompatibility

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Academic literature on the topic 'Metals in surgery - Biocompatibility'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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Journal articles on the topic "Metals in surgery - Biocompatibility"

1

Anderson, Robert E., Alice M. Bowron, and Thoralf M. Sundt. "Biocompatibility analysis of the Sundt-Kees booster clip and the Drake aneurysm clip." Journal of Neurosurgery 63, no. 6 (1985): 980–84. http://dx.doi.org/10.3171/jns.1985.63.6.0980.

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✓ A combination of the Sundt-Kees reinforcing aneurysm clip applied to a Drake aneurysm clip in a piggyback fashion was studied for possible defects due to corrosion and or tissue toxicity. These two clips, which are made of similar metal (301 stainless steel), showed little or no defects when immersed in 5% saline or when implanted in rats for 6 months. This study demonstrates that clips made of similar metals can be used piggyback in patients without ill effects provided that they are carefully handled to avoid any abrasion or misbends which could conceivably lead to corrosion.

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Chakravarthy, Chitra, Daisy Aranha, Santosh Kumar Malyala, and Ravi S. Patil. "Cast Metal Surgical Guides: An Affordable Adjunct to Oral and Maxillofacial Surgery." Craniomaxillofacial Trauma & Reconstruction Open 5 (January 1, 2020): 247275122096026. http://dx.doi.org/10.1177/2472751220960268.

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Additive manufacturing or 3-dimensional (3D) printing technology has an incredulous ability to create complex constructs with high exactitude. Surgical guides printed using this technology allows the transfer of the virtual surgical plan to the operating table, optimizing aesthetic outcomes, and functional rehabilitation. A vast variety of materials are currently being used in medical 3D printing, including metals, ceramics, polymers, and composites. The guides fabricated with titanium have high strength, excellent biocompatibility, and are sterilizable but take time to print and are expensive

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Żebrowski, Remigiusz, Mariusz Walczak, Agnieszka Korga, Magdalena Iwan, and Mirosław Szala. "Effect of Shot Peening on the Mechanical Properties and Cytotoxicity Behaviour of Titanium Implants Produced by 3D Printing Technology." Journal of Healthcare Engineering 2019 (December 19, 2019): 1–11. http://dx.doi.org/10.1155/2019/8169538.

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Structural discontinuities characterize the implants produced directly from metal powders in 3D printing technology. Mainly, the surface defects should be subjected to procedures associated with surface layer modification (likewise shot peening) resulting in the increase of the implant service life maintaining optimal biocompatibility. Therefore, the purpose of the present study was to investigate the effect of type of shot used for the peening process on the Ti-6Al-4V implants functional properties as well as the biological properties. The components were produced by DMLS (direct metal laser

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Valente, Fabrício Luciani, Letícia Corrêa Santos, Rodrigo Viana Sepúlveda, et al. "Hydroxyapatite-lignin composite as a metallic implant-bone tissue osseointegration improver: experimental study in dogs." Ciência Rural 46, no. 2 (2015): 324–29. http://dx.doi.org/10.1590/0103-8478cr20150110.

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The study aimed to evaluate biocompatibility, osteoconduction and osseointegration of a pasty composite of hydroxyapatite (20%) and lignin (80%) as a promoter of metal implant and bone tissue integration. An intramedullary Schanz pin was implanted in both tibias of fifteen bitches. In the left tibia, the pin was coated with the biomaterial at the time of surgery. Marrow cavity was also filled with the biomaterial. Right limb did not receive the biomaterial, then constituting the control group. Tibias were harvested from five animals at 8, 60 and 150 days after surgery; three of them were analy

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Chittaranjan, Bhogisetty, Late Bhamidipati Sreerama Murthy, and Turaga Ravindranath. "An Evaluation of Biocompatibility of Indigenously Produced Pure Titanium: An Experimental Study in Rabbits." Journal of Oral Implantology 38, no. 5 (2012): 575–80. http://dx.doi.org/10.1563/aaid-joi-d-09-00099.

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The indigenously produced pure titanium dental implants are economical and useful for common human use in India. The aim of this study is to test the biocompatibility of the indigenously produced pure titanium dental implant material obtained from the Defense Metallurgical Research Laboratory, Hyderabad, India, and the Institute of Nuclear Medicine and Allied Science, Delhi, India. An experimental study in rabbits was done to study the amount of ordered bone formation around the screw and cylinder type of indigenously produced pure titanium metal implant specimens. The experimental animals wer

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Tschon, M., M. Fini, G. Giavaresi, et al. "Soft Tissue Response to a New Austenitic Stainless Steel with a Negligible Nickel Content." International Journal of Artificial Organs 28, no. 10 (2005): 1003–11. http://dx.doi.org/10.1177/039139880502801007.

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This study evaluates the soft tissue response to a new austenitic stainless steel with a low nickel content (P558) in comparison with a conventional stainless steel (SSt) and a titanium alloy (Ti6Al4V). Previous findings showed its in vitro biocompatibility by culturing P558 with healthy and osteoporotic osteoblasts and its in vivo effectiveness as bone implant material. Regarding its use as a material in osteosynthesis, P558 biocompatibility when implanted in soft tissues, as subcutis and muscle, was assessed. Disks and rods of these metals were implanted in rat subcutis and in rabbit muscle,

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Ziębowicz, Anna, Bogusław Ziębowicz, and Bohdan Bączkowski. "Electrochemical Behavior of Materials Used in Dental Implantological Systems." Solid State Phenomena 227 (January 2015): 447–50. http://dx.doi.org/10.4028/www.scientific.net/ssp.227.447.

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Favorable physical and chemical properties of titanium led to its use in the medical and dental specialties such as: orthodontics, prosthodontics, dental implantology and dental surgery. Estimating the biocompatibility of the material, determine the risks and benefits with its use is a complex process. In dental implantology, the attachment of a dissimilar metal abutment (Ti6Al4V) to an implant (commercially pure Ti) forms a galvanic couple in the mouth; they are placed in physical contact in an electrically conductive mediums – body fluids.

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Prasadh, Somasundaram, Vaishnavi Ratheesh, Vyasaraj Manakari, Gururaj Parande, Manoj Gupta, and Raymond Wong. "The Potential of Magnesium Based Materials in Mandibular Reconstruction." Metals 9, no. 3 (2019): 302. http://dx.doi.org/10.3390/met9030302.

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The future of biomaterial design will rely on development of bioresorbable implant materials that completely and safely degrade in vivo after the tissues grow, without generating harmful degradation products at the targeted anatomic site. Permanent biomaterials such as Ti6Al4V alloy, 316L stainless steel, and Co-based alloys currently used in mandibular reconstruction often result in stress shielding effects due to mismatch in the Young’s modulus values between the bone and the implant, resulting in implant loosening. Also, allergic responses due to metal ion releases necessitates revision sur

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Ikedaa, M., M. Ueda, and M. Ninomi. "Recent Studies and Developments in Titanium Biomaterials." MATEC Web of Conferences 321 (2020): 02004. http://dx.doi.org/10.1051/matecconf/202032102004.

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Titanium and its alloys have a high specific strength, excellent corrosion resistance, and good biocompatibility. Therefore, these alloys are adopted as raw materials for artificial bones and joints. Furthermore, these alloys are used as materials for dental surgery. In the development of alloy design, beta-type titanium alloys that possess a lower Young’s modulus than other types of titanium alloys, e.g., Ti-6Al-4V alpha-beta-type alloys, are being actively investigated worldwide. Based on these studies, titanium-niobium-tantalum and zirconium system alloys were developed. For example, Ti-29N

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Pozzuoli, Assunta, Antonio Berizzi, Alberto Crimì, et al. "Metal Ion Release, Clinical and Radiological Outcomes in Large Diameter Metal-on-Metal Total Hip Arthroplasty at Long-Term Follow-Up." Diagnostics 10, no. 11 (2020): 941. http://dx.doi.org/10.3390/diagnostics10110941.

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Total hip arthroplasty (THA) with metal-on-metal (MoM) bearings have shown problems of biocompatibility linked to metal ion release at the local level causing an adverse reaction to metal debris (ARMD) and at a systemic level. The aim of this study was to evaluate clinical and radiological outcomes, and metal ion concentrations in the blood and urine of patients who underwent THA with the LIMA Met-Met hip system. Patients with ceramic-on-ceramic (CoC) bearings were included as a control group. In this study, 68 patients were enrolled: 34 with MoM THAs and 34 with CoC THAs. Patients were evalua

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Dissertations / Theses on the topic "Metals in surgery - Biocompatibility"

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Yuen, Chi-keung, and 袁智強. "Opportunities and limitations of "resorbable" metallic implant: risk assessment, biocorrosion andbiocompatibility, and new directions with relevance to tissueengineering and injury management techniques." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41633659.

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Yuen, Chi-keung. "Opportunities and limitations of "resorbable" metallic implant risk assessment, biocorrosion and biocompatibility, and new directions with relevance to tissue engineering and injury management techniques /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41633659.

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Vince, David Geoffrey. "The host response to implanted metals." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240748.

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Freestone, Timothy. "Some aspects of the biocompatibility of the platinum group metals." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316572.

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Ho, Joan Pui Yee. "Plasma Surface Modification of Biomedical Polymers and Metals." University of Sydney, 2007. http://hdl.handle.net/2123/2463.

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Doctor of Philosophy(PhD)<br>Biomedical materials are being extensively researched, and many different types such as metals, metal alloys, and polymers are being used. Currently used biomedical materials are not perfect in terms of corrosion resistance, biocompatibility, and surface properties. It is not easy to fabricate from scratch new materials that can fulfill all requirements and an alternative approach is to modify the surface properties of current materials to cater to the requirements. Plasma immersion ion implantation (PIII) is an effective and economical surface treatment techniq

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Nicolae, Laura Cristina. "The development of light curable biomaterials with enhanced biocompatibility for orthopaedic surgery." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6951/.

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The majority of materials used for cemented joint replacement and bone augmentation contain polymethylmethacrylate (PMMA)-based materials. Although commercially available for more than 60 years, PMM-based cements suffer from shortcomings including: the requirement of mixing in surgery of its components, high setting time and formation of a fibrous scar at the bone-implant interface, which may lead to necrosis of surrounding soft and hard tissues and failure of the implant. Incorporation of various fillers has been used to improve the physical, mechanical and biocompatibility with soft and hard

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Coe, Samuel C. "The deposition, characterisation and biocompatibility of hydroxyapatite and silicon doped hydroxyapatite thin film coatings for orthopaedic applications." Thesis, University of Nottingham, 2008. http://eprints.nottingham.ac.uk/10984/.

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Silicon doped hydroxyapatite (SiHA) could be used as a thin film coating on load bearing bone implants to provide a bioactive layer enabling bone to form a direct bond with the implant/bone interface thus increasing implant lifetime by lowering the chances of aseptic loosening. This study has been undertaken to investigate silicon additions to RF magnetron sputtered hydroxyapatite (HA) thin films. Detailed characterisation was carried out on SiHA thin films to establish the structural, chemical, mechanical and compositional properties. Silicon content was altered by adjusting the power density

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Lui, Wing-chi, and 呂穎芝. "In vitro and in vivo studies of biocompatibility of intraocular tamponade agents." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43571967.

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VIOLIN, KALAN B. "Implantes cerâmicos e metálicos - caracterização da osteointegração por imuno-histoquímica, lectina-histoquímica e marcadores fluorescentes." reponame:Repositório Institucional do IPEN, 2015. http://repositorio.ipen.br:8080/xmlui/handle/123456789/25300.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2015-12-10T17:29:01Z No. of bitstreams: 0<br>Made available in DSpace on 2015-12-10T17:29:01Z (GMT). No. of bitstreams: 0<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Tese (Doutorado em Tecnologia Nuclear)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP<br>FAPESP:10/20698-4

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Ma, Da, and 马达. "In vivo and ex vivo studies of intraocular tamponade agents and their clinical relevance in intraocular drug delivery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4454618X.

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Books on the topic "Metals in surgery - Biocompatibility"

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Jonathan, Black. Biological performance of materials: Fundamentals of biocompatibility. 2nd ed. Dekker, 1992.

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Biological performance of materials: Fundamentals of biocompatibility. 3rd ed. Marcel Dekker, 1999.

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Biological performance of materials: Fundamentals of biocompatibility. 4th ed. Taylor & Francis, 2006.

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International, Conference on Biocompatibility of Materials (1st 1988 Colorado Springs Colo ). Mercury & other toxic metals in humans: Proceedings of the first International Conference on Biocompatibility of Materials. Life Sciences Press, 1989.

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Brunette, Donald M. Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications. Springer Berlin Heidelberg, 2001.

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Thull, Roger, H. Ju rgen Breme, and C. James Kirkpatrick. Metallic biomaterial interfaces. Wiley-VCH, 2008.

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International Symposium on Metal Ions in Biology and Medicine (3rd 1994 Montréal, Québec). Metal ions in biology and medicine: Proceedings of the Third International Symposium on Metal Ions in Biology and Medicine held in Montréal (Québec), Canada, on May 17-21, 1994 = Les ions métalliques en biologie et en médecine : troisième Symposium International sur les Ions Métalliques en Biologie et en Médecine, Montréal (Québec), Canada, 17-21 mai 1994. John Libbey Eurotext, 1994.

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8

Hao, Liang. Laser surface treatment of bio-implant materials. John Wiley & Sons, 2006.

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1970-, Lawrence J., ed. Laser surface treatment of bio-implant materials. Wiley, 2005.

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Cyclic plasticity and low cycle fatigue life of metals. Elsevier, 1991.

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Book chapters on the topic "Metals in surgery - Biocompatibility"

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Silver, Frederick H., and David L. Christiansen. "Introduction to Structure and Properties of Polymers, Metals, and Ceramics." In Biomaterials Science and Biocompatibility. Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-0557-9_3.

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Leynadier, Francisque, and Francois Langlais. "Total Hip Arthroplasties and Allergy to Metals." In Biocompatibility of Co-Cr-Ni Alloys. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0757-0_18.

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Woodson, Erika. "Heavy Metals." In Encyclopedia of Otolaryngology, Head and Neck Surgery. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-23499-6_200178.

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Dielert, Eckhard, and Eberhard Fischer-Brandies. "Histochemical, Electron Microscopic and Microanalytic Investigations of Tissue Surrounding Ni-Cr-Allenthesis in Maxillo-Facial Surgery." In Biocompatibility of Co-Cr-Ni Alloys. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0757-0_13.

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Heller, W., and H. P. Wendel. "Experimental studies in hemo-and biocompatibility of artificial surfaces in cardiovascular surgery." In Current Perspectives of the Extracorporeal Circulation. Steinkopff, 2000. http://dx.doi.org/10.1007/978-3-642-57721-5_3.

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Neugebauer, R., G. Burri, and L. Claes. "Collagen-coated carbon fibers - a material for ligament replacement. An experimental study on biocompatibility and biomechanical strength." In Surgery and Arthroscopy of the Knee. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71022-3_80.

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"Biocompatibility, Metals Ions, and Corrosion Products." In Materials for Medical Devices. ASM International, 2012. http://dx.doi.org/10.31399/asm.hb.v23.a0005665.

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Cui, C., and Mitsuo Niinomi. "Biocompatibility and fabrication of in situ bioceramic coating." In Metals for Biomedical Devices. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-08-102666-3.00008-0.

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Johnson, A., and T. Shiraishi. "Biocompatibility of precious metals for medical applications." In Precious Metals for Biomedical Applications. Elsevier, 2014. http://dx.doi.org/10.1533/9780857099051.1.37.

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Wang, Mian, Wenwen Liu, and Thomas J. Webster. "The Promise of Nanometals: Reducing Infection and Increasing Biocompatibility." In Trace Metals and Infectious Diseases. The MIT Press, 2015. http://dx.doi.org/10.7551/mitpress/9780262029193.003.0021.

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Conference papers on the topic "Metals in surgery - Biocompatibility"

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Li, Yiming, Kun Sun, and Chengli Song. "Finite Element Modeling and Analysis of Ventricular Septal Defect Occluders." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6837.

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Transcatheter closure of ventricular septal defect (VSD) has become an alternative therapy to open-chest surgery because of simple procedure, less invasion, and high safety [1–2]. The most important occluder device of the therapy is double-disc structure which occludes the VSD, with the discs of the occluder clamp the margin of VSD while the waist of the occluder supports the VSD hole (Figure 1(a)). Commercially available occluders are woven by 72 nitinol wires (Figure1(b)) and then formed by heat treatment. However, the implantation of metal occluders in perimembranous part will result in a s

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Chew, H. R., J. Lawrence, C. K. Chong, and L. Hao. "Laser treatment of selected bio-metals for improved biocompatibility." In ICALEO® 2003: 22nd International Congress on Laser Materials Processing and Laser Microfabrication. Laser Institute of America, 2003. http://dx.doi.org/10.2351/1.5060110.

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Zhang, Qingwei, Vadym Mochalin, Ioannis Neitzel, Yury Gogotsi, Peter I. Lelkes, and Jack Zhou. "The Study on PLLA-Nanodiamond Composites for Surgical Fixation Devices." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-38287.

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Biopolymers have a great potential in biomedical engineering, having been used as scaffolds for hard and soft tissues, such as bone and blood vessels for many years. More recently biopolymers have also found applications in surgical fixation devices. Compared with conventional metal fixation devices, bone grafts and organ substitutes, biopolymer products have advantages of no long-term implant palpability or temperature sensitivity, predictable degradation to provide progressive bone loading and no stress shielding, all of which leads to a better bone healing, reduced patient trauma and cost,

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Pourghodrat, Abolfazl, Carl A. Nelson, and Jeff Midday. "Pneumatic Miniature Robot for Laparoendoscopic Single Incision Surgery." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70454.

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The transition from open surgery to Laparoendoscopic Single-Site (LESS) surgery to minimize cost and recovery time and improve cosmetic scarring has introduced complexities such as reduced dexterity, restricted workspace, and unintuitive controls. Surgical robotic systems can come into play to address these complexities. The most recent miniature in vivo robots have demonstrated the capability of performing LESS surgery. Since size has been a key driving force for designing these motor-driven robotic platforms, delivering adequate force and torque to perform the surgical tasks has been a prima

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Vivanco, Juan, Josh Slane, and Heidi Ploeg. "Nano-Mechanical Properties of Bioceramic Bone Scaffolds Fabricated at Three Sintering Temperatures." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53734.

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Bone grafting is an exceptionally common procedure used to repair bone defects within orthopaedics, craniofacial surgery and dentistry. It is estimated that 2.2 million grafting procedures are performed annually worldwide [1] and maintain a market share of $7 billion in the United States alone [2]. There has been a considerable rise in the interest of using bioactive ceramic materials, such as hydroxyapatite and tricalcium phosphate (TCP), to serve as synthetic replacements for autogenous bone grafts, which suffer from donor site morbidity and limited supply [3]. These ceramic materials (which

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Hu, Yingbin, Shahrima Maharubin, Weilong Cong, and George Tan. "Laser Engineered Net Shaping of Titanium-Silver Alloy for Orthopedic Implant." In ASME 2018 13th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/msec2018-6611.

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Post-surgery infection is one of the major causes of orthopedic implantation failure. Silver has been widely used as a broad-spectrum antimicrobial component in medical instrument. This paper presents a pioneering study on laser engineered net shaping (LENS) of titanium-silver (Ti-Ag) alloy for implant-related infection control. Ti-Ag alloy coupons were 3D printed through LENS process and characterized by 3D microscopy. The biofilm resistance and biocompatibility of the alloy samples were investigated. Results showed that the alloy significantly reduced the bacterial attachment for both Gram-p

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Guan, Yabo, Harlan Bruner, Narayan Yoganandan, Frank A. Pintar, and Dennis J. Maiman. "Block-Fixation Finite Element Lumbar Spine Model to Examine Load-Sharing, Bone-Screw Interaction, and Stress in Carbon Fiber Reinforced PEEK Construct." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206654.

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Carbon-fiber-reinforced (CFR) polyetheretherketone (PEEK) combines the high strength of metals with the extensive biocompatibility and imaging compatibility of polymers. CFR PEEK composite is similar to the stiffness of cortical bone (approximately 15–20 GPa) and shows comparable performance to metallic materials such as titanium alloy, cobalt chrome alloy, and stainless steel in terms of strength. CFR-PEEK becomes an attractive alternative to the metallic materials traditionally used in spinal implants (e.g. pedicle screw rod fixation). Finite element (FE) models have been developed to study

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Zhang, Yanting, Emily R. Parker, Masa P. Rao, Marco F. Aimi, Igor Mezic, and Noel C. MacDonald. "Titanium Bulk Micromachining for BioMEMS Applications: A DEP Device as a Demonstration." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-62136.

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Titanium has been widely used as a biomedical material in orthopedics, dentistry, cardiology, and cardiovascular surgery due to the excellent biostability and biocompatibility that results from its spontaneous formation of a highly passivating oxide layer in air and blood. However, little research has been done on the development of titanium for bioMEMS applications. This is likely due to the immaturity of titanium bulk micromachining technology to date. Here we report the application of new high-aspect-ratio bulk titanium micromachining techniques recently developed within our group towards t

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Bleyl, H. "TWO-SIDE IMMUNOASSAYS OF ENZYME-INHIBITOR COMPLEXES FOR THE DIAGNOSIS OF THROMBOPHILIC STATES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643113.

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The diagnosis of prethrombotic states requires methods which detect products of intravasal activation of the coagulation cascade.Two-side immunoassays for antithrombin complexes with clotting factors were developed (IXi-AT, Xi-AT, IIi- AT). These sandwich assays permit the diagnosis of hypercoagulability in the presence or absence of heparin. The biological half live time of the thrombin-antithrombin-complex was found to be about 15 min. Healthy young men 20-25 years old (n=30) have a thrombin-antithrombin-complex concentration of 0.4 ± 0.2 mU/ml thrombin equivalent (S 2238). Patients with acu

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Zhang, Qingwei, Wei Zhang, Donggang Yao, Peter I. Lelkes, and Jack G. Zhou. "The Co-Continuous Micro-Porous PLLA Scaffolds and Their Application for ACL Reconstruction." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-38291.

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Anterior cruciate ligament (ACL) reconstructive surgery is a major health concern world-wide because of a large aging population and increased occurrence of sport-related damage. Tissue engineering is a rapidly growing interdisciplinary field that offers a promising new approach for ACL repair. In order to overcome the shortages of current existing surgical fixation devices, we are combining gradient cellular structure (GCS) injection molding technique and biomedical engineering to develop novel surgical fixation devices (screw, anchor, plate, pin, staple, etc.) that not only incorporate bioac

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