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1

Vauthey, Jean-Nicolas, Paulo M. Hoff, Riccardo A. Audisio, and Graeme J. Poston, eds. Liver Metastases. Springer London, 2009. http://dx.doi.org/10.1007/978-1-84628-947-7.

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Raizer, Jeffrey J., and Lauren E. Abrey, eds. Brain Metastases. Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-69222-7.

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3

Poitout, Dominique G., ed. Bone Metastases. Springer London, 2002. http://dx.doi.org/10.1007/978-1-4471-3251-6.

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Rubens, R. D., and I. Fogelman, eds. Bone Metastases. Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-3254-7.

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5

Sawaya, Raymond, ed. Intracranial Metastases. Blackwell Publishing, Inc., 2004. http://dx.doi.org/10.1002/9780470753064.

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6

Kardamakis, Dimitrios, Vassilios Vassiliou, and Edward Chow, eds. Bone Metastases. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9819-2.

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Vassiliou, Vassilios, Edward Chow, and Dimitrios Kardamakis, eds. Bone Metastases. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-7569-5.

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8

Garden, O. J., J. G. Geraghty, D. M. Nagorney, R. A. Audisio, and H. S. Stoldt, eds. Liver Metastases. Springer London, 1998. http://dx.doi.org/10.1007/978-1-4471-1506-9.

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9

Pointillart, Vincent, Alain Ravaud, and Jean Palussière. Vertebral metastases. Springer Paris, 2002. http://dx.doi.org/10.1007/978-2-8178-0757-7.

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10

Abrey, Lauren E., Marc C. Chamberlain, and Herbert H. Engelhard, eds. Leptomeningeal Metastases. Springer-Verlag, 2005. http://dx.doi.org/10.1007/b104814.

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11

Dolgushin, Mikhail, Valery Kornienko, and Igor Pronin. Brain Metastases. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57760-9.

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12

E, Abrey Lauren, Chamberlain Marc C, and Engelhard Herbert H, eds. Leptomeningeal metastases. Springer, 2005.

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13

Ferrozzi, Francesco, Giacomo Garlaschi, and Davide Bova. CT of Metastases. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59595-0.

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14

Akira, Watanabe, ed. Cancer metastases research. Nova Science Publishers, 2008.

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15

Maurice, Slevin, ed. Management of metastases. Baillière Tindall, 1987.

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16

T, Keller Evan, and Chung Leland W. K, eds. The biology of skeletal metastases. Kluwer Academic Publishers, 2004.

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17

Denaro, Vincenzo, Alberto Di Martino, and Andrea Piccioli, eds. Management of Bone Metastases. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-73485-9.

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18

Correia, Mauro Monteiro, Michael A. Choti, Flavio G. Rocha, and Go Wakabayashi, eds. Colorectal Cancer Liver Metastases. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-25486-5.

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19

Di Carlo, Isidoro, ed. Noncolorectal, Nonneuroendocrine Liver Metastases. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-09293-5.

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20

Joerger, Markus, and Michael Gnant, eds. Prevention of Bone Metastases. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-21892-7.

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21

Ahluwalia, Manmeet, Philippe Metellus, and Riccardo Soffietti, eds. Central Nervous System Metastases. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-23417-1.

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22

Ramakrishna, Rohan, Rajiv S. Magge, Ali A. Baaj, and Jonathan P. S. Knisely, eds. Central Nervous System Metastases. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42958-4.

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23

Glehen, Olivier, and Aditi Bhatt, eds. Pathology of Peritoneal Metastases. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3773-8.

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24

1940-, Herberman Ronald B., Wiltrout Robert H, and Gorelik Elieser, eds. Immune responses to metastases. CRC Press, 1987.

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25

1938-, Jasmin Claude, ed. Textbook of bone metastases. J. Wiley & Sons, 2005.

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26

Bertoldo, Francesco, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, and Riccardo Valdagni, eds. Bone Metastases from Prostate Cancer. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-42327-2.

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27

Keller, Evan T., and Leland W. K. Chung, eds. The Biology of Skeletal Metastases. Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-9129-4.

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28

Yamada, Yoshiya, Eric Chang, John B. Fiveash, and Jonathan Knisely, eds. Radiotherapy in Managing Brain Metastases. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-43740-4.

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29

Sawaya, Raymond. Intracranial metastases: Current management strategies. Blackwell Futura, 2004.

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30

D, Rubens R., and Fogelman Ignac 1948-, eds. Bone metastases: Diagnosis and treatment. Springer-Verlag, 1991.

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31

L, Morris David, McArdle C. S, and Onik Gary 1952-, eds. Hepatic metastases: Diagnosis and management. Butterworth-Heinemann, 1996.

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32

L, Gluckman J., and Johnson Jonas T, eds. Surgical management of neck metastases. Martin Dunitz, 2003.

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33

T, Keller Evan, and Chung Leland W. K, eds. The biology of skeletal metastases. Kluwer Academic Publishers, 2004.

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34

Werner, Jochen A., and R. Kim Davis, eds. Metastases in Head and Neck Cancer. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18722-3.

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35

Capussotti, Lorenzo, ed. Surgical Treatment of Colorectal Liver Metastases. Springer Milan, 2010. http://dx.doi.org/10.1007/978-88-470-1809-9.

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36

Algra, P. R. MRI and CT of vertebral metastases. [publisher not identified], 1992.

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37

P, Van Schil, ed. Lung metastases and isolated lung perfusion. Nova Science, 2005.

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38

James, Garden O., Geraghty James G, and Nagorney D. M. 1950-, eds. Liver metastases: Biology, diagnosis, and treatment. Springer, 1998.

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39

Robin, Adam M., and Steven N. Kalkanis. Brain Metastases. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0010.

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A significant percentage of patients with systemic cancer will develop brain metastasis at some point in the course of their disease. Brain metastases should be suspected if patients with known cancer histories present with new neurologic symptoms. Treatment for brain metastasis typically involves radiation. Patients with large, symptomatic and/or solitary brain metastases may benefit from surgical resection in addition to radiation. The role of systemic therapy for brain metastases remains somewhat limited, but newer treatment strategies such as immune therapy and molecular targeted agents ma
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40

Jo, Jasmin, and David Schiff. Brain Metastases. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0141.

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In the past, detection of brain metastases signaled the conclusion of aggressive systemic treatment and shifted the focus of care toward palliation. The median survival for patients with single brain metastasis without brain-directed treatment is about a month. Whole brain radiation therapy was the traditional palliative treatment utilized, offering an additional 2 to 5 months. More recently, in addition to whole brain irradiation, the roles of surgery, stereotactic radiosurgery, chemotherapy, and targeted therapies in the definitive management of brain metastases have been investigated in num
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41

Intermolecular cross-talk in tumor metastasis. IOS Press, 1999.

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42

Valenti, Maria Teresa, and Olivier Feron, eds. Bone Metastases. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-394-3.

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43

Barzilai, Ori, Mark H. Bilsky, and Ilya Laufer. Spine Metastases. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0028.

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A decision-making framework called NOMS (neurologic, oncologic, mechanical, and systemic) facilitates and guides therapeutic decisions for patients with spinal metastases. Patients should be evaluated for signs of myelopathy or cauda equina. The Epidural Spinal Cord Compression scale facilitates reporting of the degree of radiographic spinal cord compression. A determination of the expected histology-specific tumor response to conventionally fractionated external beam radiation and systemic therapy should be made. Radiation therapy effectively treats biologic pain and radiosensitive tumors suc
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44

Liver metastases. Springer, 2009.

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45

Abrey, Lauren E., Marc Chamberlain, and Herbert Engelhard. Leptomeningeal Metastases. Springer, 2014.

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46

Pointillart, Vincent, Alain Ravaud, and Jean Palussiere. Vertebral metastases. Springer, 2002.

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47

Abrey, Lauren E., and Jeffrey J. Raizer. Brain Metastases. Springer, 2014.

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48

Poston, Graeme J., Jean-Nicolas Vauthey, Riccardo A. Audisio, and Paulo M. G. Hoff. Liver Metastases. Springer, 2010.

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49

Pointillart, Vincent, Alain Ravaud, and Jean Palussiere. Vertebral Metastases. Springer London, Limited, 2013.

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50

Skeletal metastases. Butterworths, 1986.

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