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Dissertations / Theses on the topic 'Metastases'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Wiltberger, Georg, Julian Nikolaus Bucher, Felix Krenzien, et al. "Extended resection in pancreatic metastases." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206265.

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Background: Metastases to the pancreas are rare, accounting for less then 2 % of all pancreatic malignancies. However, both the benefit of extended tumor resection and the ideal oncological approach have not been established for such cases; therefore, we evaluated patients with metastasis to the pancreas who underwent pancreatic resection. Methods: Between 1994 and 2012, 676 patients underwent pancreatic surgery in our institution. We retrospectively reviewed patients’ medical records according to survival, and surgical and non-surgical complications. Student’s t-test and the log-rank test wer

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2

GELAY, BRUNO. "Metastases de l'intestin grele." Nice, 1991. http://www.theses.fr/1991NICE6553.

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3

Holub, Ondrej. "Biomechanics of spinal metastases." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/7315/.

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The lack of suitable models for prediction of the vertebral body (VB) failure load for a variety of pathologies hampers the development of indications for surgical and pharmaceutical interventions and the assessment of novel treatments. Similar models would also be of benefit in a laboratory environment in which predictions of failure load could aid experimental design when using cadaveric tissue. Finite element modelling shows great potential but the expertise required to effectively deploy this technology in a clinical environment precludes its routine use at the present time. Its deployment

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4

STRENTA, CLAUDIO. "Chemo-embolisation des metastases hepatiques." Lyon 1, 1989. http://www.theses.fr/1989LYO1M465.

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5

Stitzlein, Russell Neil. "The role of ezrin in osteosarcoma metastasis and its potential use in early identification of metastases." Miami University Honors Theses / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1177692826.

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6

MAILHAC, CHRISTOPHE. "Les metastases de l'adenocarcinome du rein : a propos d'un cas avec metastases pancreatiques, surrenalienne et thyroidienne." Reims, 1989. http://www.theses.fr/1989REIMM022.

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7

Sutton, Christopher Derek. "Angiogenesis in resected colorectal liver metastases." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29870.

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Aims: To assess the prognostic significance of angiogenesis using microvessel density (MVD) and angiogenesis-modulating cytokines, in a consecutive series of patients undergoing liver resection for colorectal metastases. Methods: 5 microm sections from formalin-fixed, paraffin-embedded tissue blocks were immunohistochemically stained for microvessels, vascular endothelial growth factor (VEGF) thrombospondin-1 (TSP-1), thymidine phosphorylase (TP) and p53. MVD was measured using a computerised image analysis system. At the edge of the tumour, areas of highest vessel counts or hotspots, and the

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8

Schackert, Gabriele, Stephan B. Sobottka, A. Steinmetz, and Matthias Kirsch. "Current Treatment Strategies in Brain Metastases." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135160.

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Brain metastases are treated with surgery, radiotherapy, radiosurgery, and chemotherapy. In this review, recently published studies concerning different treatment strategies are presented with respect to solitary lesions, multiple metastases, and recurrent tumor growth. Selection criteria for the appropriate therapy are: control of the primary tumor, extent of extracerebral metastases, time interval between diagnosis of the primary tumor and the development of cerebral lesions, number of cerebral metastases, Karnofsky performance scale score, and age. Treatment approaches were evaluated with r

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9

Schackert, Gabriele, Stephan B. Sobottka, A. Steinmetz, and Matthias Kirsch. "Current Treatment Strategies in Brain Metastases." Karger, 2000. https://tud.qucosa.de/id/qucosa%3A27625.

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Brain metastases are treated with surgery, radiotherapy, radiosurgery, and chemotherapy. In this review, recently published studies concerning different treatment strategies are presented with respect to solitary lesions, multiple metastases, and recurrent tumor growth. Selection criteria for the appropriate therapy are: control of the primary tumor, extent of extracerebral metastases, time interval between diagnosis of the primary tumor and the development of cerebral lesions, number of cerebral metastases, Karnofsky performance scale score, and age. Treatment approaches were evaluated with r

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10

JOLIVET, THIERRY. "Metastases au cours du carcinome hepatocellulaire." Nice, 1989. http://www.theses.fr/1989NICE6540.

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11

Davids, Virginia. "Molecular detection of melanoma nodal metastases." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/3375.

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Includes bibliography.<br>The aim of this study was to develop a practical and reproducible multi-marker RT-PCR essay, with the emphasis on achieving maximum specificity for the detection of melanoma nodal metastases. A novel protocol for the efficient homogenisation of nodal tissue was developed, with clinical applicability as the objective.

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12

HUMBERT, FRANCOIS-PHILIPPE. "Les metastases osseuses revelatrices des hepatocarcinomes." Lyon 1, 1991. http://www.theses.fr/1991LYO1M319.

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13

ORTEGA, NICOLE. "Metastases viscerales tardives des melanomes choroidiens." Toulouse 3, 1989. http://www.theses.fr/1989TOU31237.

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14

BERKMANS, SOPHIE. "Metastases synoviales : a propos d'un cas." Reims, 1990. http://www.theses.fr/1990REIMM102.

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15

Marshall, Leslie-Jayne. "Hypoxia and angiogenesis in colorectal liver metastases." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29498.

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Introduction: Despite surgical resection being the only potential cure for colorectal liver metastases, not all patients are suitable for operative intervention. Most patients who undergo surgery die of recurrent disease. Understanding tumour behaviour may identify patients who might benefit from targeted adjuvant therapy. Tumour hypoxia and angiogenesis are a negative prognostic factor in various solid tumours. Carbonic anhydrase IX (CAIX), epidermal growth factor receptor (EGFR), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) have been associated with poor outcome.

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16

SCHISCHMANOV, NICOLA. "New Hypothesis on the Origin of Metastases." Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/17613.

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17

Schackert, Gabriele. "Surgery of Brain Metastases – Pro and Contra." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135071.

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Conclusion: Surgery should be considered whenever possible. This means that the patient has to be in good clinical condition (Karnofsky performance score > 70), the extracerebral metastases should be stable, the number of cerebral lesions should not exceed more than 3 seedings, and the age of the patient should be below 70 years. Since brain metastases are usually well circumscribed, complete extirpation seems to be possible. Postoperative MRI should be demanded in order to confirm complete extirpation. Additional radiotherapy is indicated in case of subtotal resection of a single lesion an

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18

Schackert, Gabriele. "Surgery of Brain Metastases – Pro and Contra." Karger, 2002. https://tud.qucosa.de/id/qucosa%3A27616.

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Conclusion: Surgery should be considered whenever possible. This means that the patient has to be in good clinical condition (Karnofsky performance score > 70), the extracerebral metastases should be stable, the number of cerebral lesions should not exceed more than 3 seedings, and the age of the patient should be below 70 years. Since brain metastases are usually well circumscribed, complete extirpation seems to be possible. Postoperative MRI should be demanded in order to confirm complete extirpation. Additional radiotherapy is indicated in case of subtotal resection of a single lesion and i

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19

MORIN, HUGUENIN ISABELLE. "Metastases cervicales uterines dans les epitheliomas mammaires." Nantes, 1990. http://www.theses.fr/1990NANT139M.

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20

Froehner, Michael, Tobias Hölscher, Oliver W. Hakenberg, and Manfred P. Wirth. "Treatment of Bone Metastases in Urologic Malignancies." Karger, 2014. https://tud.qucosa.de/id/qucosa%3A71672.

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The skeletal system is the most common site of metastatic cancer spread. Bone metastases are often associated with severe morbidity, pain and functional impairment. Timely diagnosis and proper treatment may decrease morbidity, improve quality of life and in some cases even improve survival. External beam radiotherapy may effectively give pain relief in patients with painful bone metastases. In bone metastases from castration-resistant prostate cancer or urothelial bladder cancer, treatment with zoledronic acid or denosumab may reduce skeletal-related events. In contrast to castration-resistant

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21

OLIVIER, BENOIT. "Les metastases mandibulaires dans les cancers bronchiques." Lille 2, 1994. http://www.theses.fr/1994LIL2M019.

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22

Ulahannan, Danny. "Characterisation of the genomes of brain metastases." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:a848ace8-25a5-4d26-8a16-e80cf5e6e04f.

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Brain metastases are generally associated with a poor prognosis. The number of metastases, location and control of extracranial disease typically influences the management of patients. Treatment options are currently limited and are dependent on the clinical context. Interventions include surgery and stereotactic radiosurgery with few metastases, with whole brain radiotherapy serving a role in patients with several metastases. In recent years, there have been increased efforts directed towards early phase trials to address the role of targeted biological agents towards pathogenic drivers namel

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23

JEUNET, ERIC. "Hepatectomies iteratives pour metastases de cancers digestifs." Lyon 1, 1990. http://www.theses.fr/1990LYO1M394.

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24

CLAVEAU, CHRISTOPHE. "Metastases surrenaliennes des carcinomes et retentissement hormonal." Angers, 1990. http://www.theses.fr/1990ANGE1022.

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25

GADAY, VERONIQUE. "Incidence des metastases septiques dans l'endocardite infectieuse." Lille 2, 1994. http://www.theses.fr/1994LIL2M131.

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26

Iwata, Hisashi, Shigeki Yamamura, Hideshi Sugiura, et al. "Clinical results of nonsurgical treatment for spinal metastases." Thesis, Elsevier, 1998. http://hdl.handle.net/2237/16692.

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27

Breen, Stephen L. "Improved dosimetry for systemic radiotherapy of bone metastases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0009/NQ42563.pdf.

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28

Oostenbrugge, Robert Jan van. "Interphase cytogenetics in the cytodiagnosis of leptomeningeal metastases." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6838.

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29

Gurusamy, K. S. "Role of trace elements in colorectal liver metastases." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1302062/.

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Trace elements are involved in many key metabolic pathways. Literature review demonstrated that the trace element content in liver metastases is lower than that in surrounding livers and that in livers of normal individuals. The significance of trace elements in the diagnosis, prognosis, and treatment of patients undergoing surgical resection for colorectal liver metastases (CLM) is not known. Samples obtained from patients who underwent liver resection for colorectal liver metastases were used for this research. Iron, copper and zinc content were measured by X-ray fluorescence (XRF) and were

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30

Webster, Peter John. "Targeting tumour angiogenesis in colorectal cancer liver metastases." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16824/.

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Colorectal cancer liver metastases (CLM) remain a significant cause of cancer-related morbidity and mortality. Central to their survival and growth is the process of tumour angiogenesis. Current clinical anti-angiogenic therapies target vascular endothelial growth factor signalling, but resistance to therapy is problematic. The aim of this study was to identify proteins critical for CLM endothelial cell (CLMEC) survival that could be targeted for the development of new anti-angiogenic therapies. CLMECs and endothelial cells of normal adjacent liver (LECs) were isolated from patients undergoing

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31

BOURGOGNE, ERIC. "Metastases pancreatiques des osteosarcomes : a propos d'un cas." Besançon, 1992. http://www.theses.fr/1992BESA3020.

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32

Cabane, Jean-Pierre. "Metastases renales : a propos de dix-neuf cas." Nice, 1989. http://www.theses.fr/1989NICE6530.

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33

BOURGEOIS, PIERRE. "Les metastases pulmonaires de l'osteosarcome et leur traitement." Nancy 1, 1988. http://www.theses.fr/1988NAN11199.

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34

Chen, Zhaomin. "Human Liver Metastases: Chemometrics of Imaging FTIR Data." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437662269.

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35

BELHAJ, NABIL, and RACHID BAKKALI. "Metastases extraencephaliques des glioblastomes : a propos d'une observation." Lille 2, 1993. http://www.theses.fr/1993LIL2M099.

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36

RANDAVEL, JEAN-LUC. "Les metastases de l'intestin grele du melanome cutane." Amiens, 1991. http://www.theses.fr/1991AMIEM010.

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37

Jouart, Daniel. "Epithelioma thyroidien primitif de l'ovaire avec metastases osseuses." Université Louis Pasteur (Strasbourg) (1971-2008), 1985. http://www.theses.fr/1985STR1M271.

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38

Lemma, Silvia <1985&gt. "Tumor microenvironment as a target of osteolytic metastases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7587/1/Lemma_Silvia_tesi.pdf.

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Bone is one of the most common sites of distant metastases from breast carcinoma. In lytic bone metastasis, tumor associated-osteoclasts are the main actors of bone resorption. Under physiological conditions, osteoclast formation is activated by cytokines and hormones produced by bone-resident cells, including osteoblasts and mesenchymal stem cells. However, when tumor cells spread to the bone, they disrupt the delicate balance between cells orchestrating osteoclast formation, thereby promoting bone resorption. Current treatments of metastatic bone disease are largely ineffective to improve pa

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39

Lemma, Silvia <1985&gt. "Tumor microenvironment as a target of osteolytic metastases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7587/.

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Bone is one of the most common sites of distant metastases from breast carcinoma. In lytic bone metastasis, tumor associated-osteoclasts are the main actors of bone resorption. Under physiological conditions, osteoclast formation is activated by cytokines and hormones produced by bone-resident cells, including osteoblasts and mesenchymal stem cells. However, when tumor cells spread to the bone, they disrupt the delicate balance between cells orchestrating osteoclast formation, thereby promoting bone resorption. Current treatments of metastatic bone disease are largely ineffective to improve pa

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40

CHAMPETIER, YVAN. "Oligodendrogliome avec metastases extranevraxiques : a propos d'un cas." Lyon 1, 1992. http://www.theses.fr/1992LYO1M273.

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41

JEANNEAU, PHILIPPE. "Les metastases choroidiennes : a propos de 18 cas." Toulouse 3, 1989. http://www.theses.fr/1989TOU31021.

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42

Trogisch-Hause, Antje. "Die Hepatische Transitzeit des Echosignalverstärkers SonoVue® beim Hund." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-78386.

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Gegenstand und Ziel: Einsatz des Ultraschallkontrastmittels SonoVue® zur Ermittlung der Hepatischen Transitzeit bei lebergesunden Hunden. Material und Methoden: Untersucht wurden 45 lebergesunde Hunde aus dem Patientengut der Klinik für Kleintiere der Universität Leipzig. Ausschlusskriterien waren Leber- und Herz-Kreislauferkrankungen, sowie Tumorleiden. Die Kontrastmitteluntersuchungen erfolgten am narkotisierten Tier. Das Kontrastmittel wurde intravenös appliziert. Die Zeitdifferenz zwischen Ankunft in den Leberarterien bis zum Erreichen der Lebervenen wird als Hepatische Transitzeit defin

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43

Farkasova, Katarina. "Bioluminescence imaging of luciferase transgenes in tumor metastases models." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-139409.

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44

Stankiewicz, Elzbieta. "Identification of the genetic alterations in prostate cancer metastases." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24630.

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Prostate cancer (PCa) is the most common cancer among men in Western developed countries. While the majority of PCa diagnosed by PSA screening are indolent, advanced and metastatic disease has a significant mortality and morbidity. Bone metastases are extremely common in PCa and identification of bone metastasis associated genes may provide insights into PCa progression and assist in finding new drug targets. However, the genetic study of bone metastases is very limited due to the difficulty of sampling. We performed genome-wide analysis of six fresh frozen PCa bone metastases. We found severa

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45

Dunne, D. "Improving the perioperative management of resectable colorectal liver metastases." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3016647/.

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Background Colorectal liver metastases (CRLM) are more prevalent with advancing age. Worldwide trends towards longer life expectancy result in a more prevalent disease in an increasingly aged co-morbid population. Utilising enhanced recovery after surgery (ERAS) and better preoperative assessment of patients using cardiopulmonary exercise testing (CPET) may in part mitigate the challenges of dealing with a more elderly co-morbid population. However significant challenges remain. Prehabilitation seeks to prevent injury, or minimise its impact before it occurs. This thesis describes the developm

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46

Blackledge, Matthew David. "Assessing response in bone metastases using diffusion weighted MRI." Thesis, University of London, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548045.

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47

CUMIN, ISABELLE. "Metastases cerebrales des cancers bronchiques non a petites cellules." Nantes, 1993. http://www.theses.fr/1993NANT223M.

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48

DESCAMPS, CECILE. "Pheochromocytome malin et metastases osseuses : a propos d'une observation." Reims, 1989. http://www.theses.fr/1989REIMM132.

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49

SOULARD, FREDERIC. "Metastases hepatiques de tumeur carcinoide : etude de 14 cas." Nantes, 1993. http://www.theses.fr/1993NANT028M.

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50

ZARKA, SERGE. "Contribution a l'etude des metastases osseuses d'un cancer endometral." Amiens, 1988. http://www.theses.fr/1988AMIEM032.

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