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Journal articles on the topic 'Metastasis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Al-Muqbel, Kusai M. "Bone Marrow Metastasis Is an Early Stage of Bone Metastasis in Breast Cancer Detected Clinically by F18-FDG-PET/CT Imaging." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/9852632.

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Objective. To determine the value of 18F-FDG PET/CT in detection of bone marrow (BM) metastasis in breast cancer which is considered an early stage of bone metastasis. Patients and Methods. Retrospectively, breast cancer patients with bone metastasis were included. BM metastasis was considered if the lesion was PET positive/CT occult while bone metastasis was considered if the lesion was PET positive/ CT positive. BM metastases were observed sequentially on F18-FDG PET/CT. Results. We included 35 patients. Eighteen patients (51%) had BM metastases in addition to other bone metastases. BM metas

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Rajae, Elaouni, Moutei Hassan, Bennis Ahmed, Chraibi Fouad, Abdellaoui Meriem, and Benatiya Andaloussi Idriss. "Unusual Case of Secondary Glaucoma: Uveal Metastasis from Breast Cancer." Scholars Journal of Medical Case Reports 13, no. 03 (2025): 378–82. https://doi.org/10.36347/sjmcr.2025.v13i03.010.

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Introduction: Uveal metastasis is the most common form of intraocular malignancy. Most uveal metastais occur in the posterior uvea, and iris metastasis are relatively rare. They may present as stromal nodules or ill-defined iris thickening, or they may be associated with atypical features such as pain or iridocyclitis. Objective and Methodes: We report the case of a 54-year-old patient whose ophthalmological examination revealed a relapse of her neoplastic disease. We emphasize the importance of a detailed medical history and a systematic general examination to establish an accurate diagnosis

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Qin, Lang, Xiangtian Yu, Chuang Xu, and Yangchen Liu. "Prognostic impact of metastatic patterns and treatment modalities on overall survival in lung squamous cell carcinoma: A population-based study." Medicine 102, no. 29 (2023): e34251. http://dx.doi.org/10.1097/md.0000000000034251.

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This study aimed to investigate the impact of distinct metastasis patterns on the overall survival (OS) of individuals diagnosed with organ metastatic lung squamous cell carcinoma (LUSC). OS was calculated using the Kaplan–Meier method, and univariate and multivariate Cox regression analyses were conducted to further assess prognostic factors. A total of 36,025 cases meeting the specified criteria were extracted from the Surveillance, Epidemiology, and End Results database. Among these patients, 30.60% (11,023/36,025) were initially diagnosed at stage IV, and 22.03% (7936/36,025) of these indi

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Fidler, Isaiah J. "Melanoma Metastasis." Cancer Control 2, no. 5 (1995): 398–404. http://dx.doi.org/10.1177/107327489500200503.

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Cancer metastasis requires a series of sequential steps, each of which is rate limiting. Neoplasms are biologically heterogeneous, and the process of metastasis is highly selective. Multiple metastases often differ in biologic characteristics and can change during the course of the disease. Clonal analysis of human melanoma suggest that systemic, physiologic signals can be recognized by neoplastic cells. Brain metastases are particularly common in patients with metastatic melanoma. The blood brain barrier does not prevent the invasion of the brain parenchyma by circulating metastatic cells, an

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Ali, Kamran, Sukki Cho, Hyo Jun Jang, Kwhanmien Kim, and Sanghoon Jheon. "Predictive Factors of Thoracic Lymph Node Metastasis Accompanying Pulmonary Metastasis from Colorectal Cancer." Thoracic and Cardiovascular Surgeon 67, no. 08 (2018): 683–87. http://dx.doi.org/10.1055/s-0038-1642602.

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Background The aim of this study was to identify the factors predicting thoracic lymph node (LN) metastases for pulmonary resection from colorectal cancer (CRC). Methods The records of 160 patients who underwent pulmonary metastasectomy for CRC were retrospectively reviewed. Clinicopathologic factors were analyzed with chi-square test or t-test and logistic regression to identify predictable factors for LN metastases. Results Sixty patients (37.5%) underwent LN dissection during pulmonary metastasectomy, and LN metastases were found in five patients. Twenty-three patients had LN recurrence amo

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Isidro, Ulysses, Liam M. O'Brien, and Ronnie Sebro. "Linear mixed-effects models for estimation of pulmonary metastasis growth rate: implications for CT surveillance in patients with sarcoma." British Journal of Radiology 93, no. 1114 (2020): 20190856. http://dx.doi.org/10.1259/bjr.20190856.

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Objectives: Sarcoma patients often undergo surveillance chest CT for detection of pulmonary metastases. No data exist on the optimal surveillance interval for chest CT. The aim of this study was to estimate pulmonary metastasis growth rate in sarcoma patients. Methods: This was a retrospective review of 95 patients with pulmonary metastases (43 patients with histologically confirmed metastases and 52 with clinically diagnosed metastases) from sarcoma treated at an academic tertiary-care center between 01 January 2000 and 01 June 2019. Age, sex, primary tumor size, grade, subtype, size and volu

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Choi, Hee Jun, Jai Min Ryu, Byung Joo Chae, et al. "Is Sentinel Lymph Node Biopsy for Breast Cancer with Cytology-Proven Axillary Metastasis Safe? A Prospective Single-Arm Study." Journal of Clinical Medicine 10, no. 20 (2021): 4754. http://dx.doi.org/10.3390/jcm10204754.

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The purpose of this study was to evaluate pathologic lymph node metastasis in breast cancer with cytology-proven axillary metastasis. This study was designed prospectively. We performed axillary lymph node dissections (ALND) after lymphatic mapping by near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG). We evaluated 72 breast cancer patients with cytology-proven axillary metastasis by curative surgery at the Samsung Medical Center between May of 2016 and December of 2017. Among the 72 patients with cytology-proven axillary metastasis, 14 of 39 patients (35.9%) with one or two

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Park, Hyung Kyu, Joungho Han, Ghee Young Kwon, Min-Kyung Yeo, and Go Eun Bae. "Patterns of Extrathoracic Metastasis in Lung Cancer Patients." Current Oncology 29, no. 11 (2022): 8794–801. http://dx.doi.org/10.3390/curroncol29110691.

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Metastasis is a major cause of death in lung cancer patients. Therefore, a deeper understanding of the metastatic mechanisms is important for developing better management strategies for lung cancer patients. This study evaluated the patterns of extrathoracic metastases in lung cancer. We retrieved data for 25,103 lung cancer patients from an institutional database and then evaluated the impacts of clinicopathologic factors on metastasis patterns. We found that 36.5% of patients had extrathoracic metastasis. Younger patients had a significantly higher extrathoracic metastasis rate in most histo

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Pisani, P., G. Angeli, M. Krengli, and F. Pia. "Renal carcinoma metastasis to the parotid gland." Journal of Laryngology & Otology 104, no. 4 (1990): 352–54. http://dx.doi.org/10.1017/s0022215100112691.

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AbstractMetastatic tumours in major salivary glands are uncommon with a higher incidence of primary sites from the head and neck. The lungs and breast are the common primary sites, while metastases from the kidney are very rarely found. The authors describe a case of renal clear-cell carcinoma with metastastis to the parotid gland. The incidence of a metastasis in the parotid gland from a primary renal carcinoma, even if rare, should not be overlooked in making a correct differential diagnosis with acinic cell carcinoma and monomorphic clear cell adenoma.

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Li, Chuang, Zhao-zhong Meng, Jian-wu Qin, and Xin-guang Qiu. "Analysis of Risk Factors of Level V Lymphatic Metastasis for Papillary Thyroid Carcinoma with pN1b." Journal of Oncology 2021 (August 18, 2021): 1–5. http://dx.doi.org/10.1155/2021/5562065.

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Objective. To explore the risk factors of level V lymphatic metastasis in papillary thyroid carcinoma (PTC) patients with pN1b. Methods. Patients were selected if they presented with a suspicious level III or IV lymph node metastasis and underwent surgery by hemi or total thyroidectomy with a lymph node dissection (levels III, IV, VI, and VII). For these patients, if frozen section showed a positive level III or IV node, then levels II and V nodes were resected. Univariate analysis was performed using the chi-square test for some factors, including age, sex, tumor location, multifocal lesions,

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Suki, Dima, Rami Khoury Abdulla, Minming Ding, Soumen Khatua, and Raymond Sawaya. "Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center." Journal of Neurosurgery: Pediatrics 14, no. 4 (2014): 372–85. http://dx.doi.org/10.3171/2014.7.peds13318.

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Object Metastasis to the brain is frequent in adult cancer patients but rare among children. Advances in primary tumor treatment and the associated prolonged survival are said to have increased the frequency of brain metastasis in children. The authors present a series of cases of brain metastases in children diagnosed with a solid primary cancer, evaluate brain metastasis trends, and describe tumor type, patterns of occurrence, and prognosis. Methods Patients with brain metastases whose primary cancer was diagnosed during childhood were identified in the 1990–2012 Tumor Registry at The Univer

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Costa, Weruska Alcoforado, José Eleutério Jr., Paulo César Giraldo, and Ana Katherine Gonçalves. "Quality of life in breast cancer survivors." Revista da Associação Médica Brasileira 63, no. 7 (2017): 583–89. http://dx.doi.org/10.1590/1806-9282.63.07.583.

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Summary Objective: To evaluate the influence of functional capacity (FC) and how it affects quality of life (QoL) in breast cancer survivors. Method: A total of 400 breast cancer survivors were studied - 118 without metastasis, 160 with locoregional metastasis and 122 with distant metastasis. The European Organization for Research and Treatment for Cancer Quality of Life Questionnaire--Core 30 (EORTC QLQ-C30), Breast Cancer-Specific (EORTC QLQ-BR23), and the Karnofsky Performance Scale (KPS) were used to evaluate FC and QoL. Results: Women with distant metastases presented lower KPS 75.3 (SD=1

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Wang, Yuezhu, Margaret R. Smith, Yin Liu, et al. "Abstract 3782: IASLC grading system predict distant metastases for resected lung adenocarcinoma." Cancer Research 84, no. 6_Supplement (2024): 3782. http://dx.doi.org/10.1158/1538-7445.am2024-3782.

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Abstract The International Association for the Study of Lung Cancer (IASLC) proposed a new histological grading system for invasive lung adenocarcinoma (LUAD). However, whether this new grading system is able to predict distant metastases in LUAD patients has not been evaluated. This study investigated the feasibility of using this grading system to predict the occurrence of brain and bone metastases in patients with resectable LUAD which identifies patients who have a high probability of developing distant metastases after surgery. We collected clinical information and pathological reports of

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Vasilev, Nikolay, Vladimir Perelmuter, Yevgeniy Choynzonov, et al. "ANALYSIS OF CASES WITH LYMPHOGENOUS METASTASIS FROM CHONDROSARCOMA." Problems in oncology 65, no. 5 (2019): 736–43. http://dx.doi.org/10.37469/0507-3758-2019-65-5-736-743.

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Between 2008 and 2017, 87 patients with lymphogenous metastasis from chondrosarcoma were treated at the Cancer Research Institute (Tomsk, Russia). Lymph node metastases were detected in 3 patients (3.4 %). All cases with lymphogenous metastases were characterized by the presence of the tumor in the appendicular skeleton, tumor extension beyond the bone with the formation of extraossal component, high-grade tumor (G2 and G3) and disease progression. Our study indicates the importance of the study of lymphogenous metastasis as evidence of an unfavorable outcome for chondrosarcoma. Further studie

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Zhang, Lei, Chengyu Wu, Yong Zhang, and Robert M. Hoffman. "Spontaneous and cyclophosphamide-enhanced metastasis inhibited by traditional Chinese medicine (TCM) herbal mixture LQ." Journal of Clinical Oncology 31, no. 15_suppl (2013): e22209-e22209. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22209.

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e22209 Background: Cyclophosphamide pretreatment of mice enhances metastatsis of HT1080 human fibrosarsoma cells (Cancer Res. 68, 516-520, 2008). Methods: HT1080 human fibrosarsoma cells were injected into the footpad or were injected into the epigastric cranialis vein of mice pre-treated with cyclophosphamide (CYC) or a combination of CYC and the herbal mixture LQ. The efficacy was monitored through dynamic subcellular imaging of trafficking of cancer cells in lymph nodes and blood vessels in live mice. Results: LQ significantly inhibited HT1080 spontaneous metastases to local lymph nodes in

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Asano, Naofumi, Michiro Susa, Seiichi Hosaka, et al. "Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience." Sarcoma 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/345161.

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Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital were used for the evaluation. 47 patients (81%) had no metastases, whereas 11 patients (11%) had metastases during their clinical course. Among the 11 patients with metastatic lesions, 8 patients (73%) had extrapulmonary metastases and 3 patients (27%) had pulmonary metastases. Patients were further

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Begum, Shamim MF, Fatima Begum, Pupree Mutsuddy, Layla S. Banu, and Raihan Hussain. "Superficial Metastases from Breast Cancer and Gallbladder: Detected by 18F FDG PET-CT Scan." Bangladesh Journal of Nuclear Medicine 20, no. 1 (2018): 56. http://dx.doi.org/10.3329/bjnm.v20i1.36862.

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<p>Cutaneous and subcutaneous metastases from internal malignancies are rare. The reported incidence of subcutaneous metastasis is 5.3% and cutaneous metastasis account for 0.7% and 9% of all metastases. Here we reported two cases of cutaneous metastasis, one from gall bladder cancer and other from breast cancer. Among all internal malignancies the incidence of cutaneous metastasis in breast cancer is highest whereas in gall bladder cancer is rare. Detection of cutaneous or subcutaneous metastasis determines the staging, prognosis and management strategy of the disease. 18F FDG PET- CT (

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Özer, Özge, Emirhan Nemutlu, Cemil Can Eylem, et al. "Detection of brain metastasis by metabolomics methods in metastatic breast cancer patients." Journal of Clinical Oncology 37, no. 15_suppl (2019): e12572-e12572. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e12572.

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e12572 Background: The aim of this study was to identify markers for the early diagnosis of brain metastasis by metabolomic methods in breast cancer patients. Methods: A total of 88 breast cancer patients with distant metastases were included the study. The patients were divided into two groups according to their metastasis status as patients with brain metastases and patients with distant metastases without any brain metastases. For metabolomic analyses, liquid chromatography quadrupole time-of-flight mass spectrometry (LC-qTOF-MS) and gas chromatography mass spectrometry (GC-MS) analysis met

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Chan, Chung Ming, Adam D. Lindsay, Andre RV Spiguel, Mark T. Scarborough, and C. Parker Gibbs. "Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes." Rare Tumors 12 (January 2020): 203636132096006. http://dx.doi.org/10.1177/2036361320960060.

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Brain metastases are a rare occurrence in patients with sarcoma. The prognosis for patients is poor, and treatment can contribute to considerable morbidity. We sought to examine the experience of our institution in managing these patients over a period of 17 years. We performed a retrospective cohort study of patients managed for sarcoma of the extremity or trunk who developed brain metastases from 2000 to 2017. Clinical data were analyzed and we assessed survival outcomes. 14 patients presenting at a mean age of 46.7 years were included. All patients were treated with radiotherapy for their b

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Gill, Jennifer G., Samantha N. Leef, Vijayashree Ramesh, et al. "A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma." Cancer Research 82, no. 7 (2022): 1251–66. http://dx.doi.org/10.1158/0008-5472.can-21-2062.

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Abstract Despite being the leading cause of cancer deaths, metastasis remains a poorly understood process. To identify novel regulators of metastasis in melanoma, we performed a large-scale RNA sequencing screen of 48 samples from patient-derived xenograft (PDX) subcutaneous melanomas and their associated metastases. In comparison with primary tumors, expression of glycolytic genes was frequently decreased in metastases, whereas expression of some tricarboxylic acid (TCA) cycle genes was increased in metastases. Consistent with these transcriptional changes, melanoma metastases underwent a met

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Muratori, Francesco, Leonardo Bettini, Filippo Frenos, et al. "Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution." International Journal of Surgical Oncology 2018 (May 16, 2018): 1–9. http://dx.doi.org/10.1155/2018/8928706.

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Objectives. The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern. Methods. 148 MLs were analyzed. The sites of metastases were investigated. Results. Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factor

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Xiong, Min, Weiguang Zhang, Chao Zhou, Junjie Bao, Shengbing Zang, and Xiaoping Lin. "Application of 18F Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Monitoring Gastric Metastasis and Cancer Thrombi from Renal Cell Carcinoma." Journal of Oncology 2022 (February 4, 2022): 1–13. http://dx.doi.org/10.1155/2022/5681463.

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Background. Renal cell carcinoma (RCC) with gastric metastasis is rare, particularly accompanied by multiple cancer thrombi. Methods. We reported a 66-year-old man with a history of a right radical nephrectomy because of RCC. The patient underwent 18F prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) scanning after 6 months of targeted therapy because of gastric metastasis and cancer thrombi. We conducted a systematic review of the literature and identified 73 cases of RCC with gastric metastasis. We analyzed the clinicopathological characteris

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Sassu, Carolina Maria, Claudia Marchetti, Giorgia Russo, et al. "Epithelial ovarian cancer and brain metastases: might theBRCAstatus, PARP inhibitor administration, and surgical treatment impact the survival?" International Journal of Gynecologic Cancer 34, no. 1 (2024): 88–98. http://dx.doi.org/10.1136/ijgc-2023-004980.

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ObjectiveTo evaluate disease characteristics and survival according toBRCAstatus, administration of poly-(ADP-ribose) polymerase inhibitors (PARPi), and surgery in patients with ovarian cancer and brain metastases.MethodsThis is a monocentric retrospective cohort of patients with ovarian cancer and brain metastases treated between 2000 and 2021. Data were collected by a retrospective review of medical records and analyzed according to: (1)BRCAmutation; (2) PARPi before and after brain metastases; (3) surgery for brain metastases.ResultsEighty-five patients with ovarian cancer and brain metasta

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Reticker-Flynn, Nathan E., Weiruo Zhang, Julia Ann Belk, et al. "Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immune tolerance." Journal of Immunology 208, no. 1_Supplement (2022): 119.04. http://dx.doi.org/10.4049/jimmunol.208.supp.119.04.

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Abstract The majority of cancer deaths result from distant organ metastasis. Lymph nodes (LNs) are major sites of anti-tumor lymphocyte education, yet LN metastasis frequently precedes distant metastasis. Here, we find that LN metastasis represents a critical step in tumor progression by inducing tumor-specific immune tolerance, thus enabling further dissemination of tumors to distant organs. Using an in vivo passaging approach, we generated 300 cell lines exhibiting varying degrees of LN metastatic capacity. We show that the LN metastases promote distant organ metastasis in a manner that is t

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Grigoryeva, Evgeniya S., Luibov A. Tashireva, Olga E. Savelieva та ін. "The Association of Integrins β3, β4, and αVβ5 on Exosomes, CTCs and Tumor Cells with Localization of Distant Metastasis in Breast Cancer Patients". International Journal of Molecular Sciences 24, № 3 (2023): 2929. http://dx.doi.org/10.3390/ijms24032929.

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Integrins are cell adhesion receptors, which play a role in breast cancer invasion, angiogenesis, and metastasis. Moreover, it has been shown that exosomal integrins provide organotropic metastasis in a mouse model. In our study, we aimed to investigate the expression of integrins β3, β4, and αVβ5 on exosomes and tumor cells (circulating tumor cells and primary tumor) and their association with the localization of distant metastasis. We confirmed the association of exosomal integrin β4 with lung metastasis in breast cancer patients. However, we were unable to evaluate the role of integrin β3 i

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Guo, Jianbin, Xiujuan Cui, Xindong Zhang, Haili Qian, Hua Duan, and Ying Zhang. "The Clinical Characteristics of Endometrial Cancer With Extraperitoneal Metastasis and the Value of Surgery in Treatment." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382094578. http://dx.doi.org/10.1177/1533033820945784.

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Objective: To describe the clinical and pathological features of endometrial carcinoma with extraperitoneal metastasis and examine whether surgery could improve the prognosis. Methods: The Surveillance, Epidemiology, and End Results database was used to analyze 730 patients who were diagnosed with extraperitoneal metastasis of endometrial cancer from 2010 to 2015, including metastasis to the lung, bone, or brain. Results: Of the 730 patients, 372 (50.96%) patients had single lung metastases, and 196(26.85%) patients had multiple organ metastases that included pulmonary invasion. Therefore, the

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Chao, Z., X. Guo, Y. Xu, X. Han, X. Wang, and G. Wang. "The Homogeneous and Heterogeneous Risk Factors for the Morbidity and Prognosis of Bone Metastasis in Patients With Prostate Cancer." Journal of Global Oncology 4, Supplement 2 (2018): 51s. http://dx.doi.org/10.1200/jgo.18.38300.

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Background: Globally, prostate cancer is the second most common malignancy in males and fifth leading cancer-related cause of death. To build a reliable predictive system for screening performance, the study looking into the risk factors of BM in prostate cancer patients is warranted. Aim: Using the Surveillance, Epidemiology, and End Results database (SEER) to assess the incidence, and risk factors of morbidity and prognosis for bone metastases in initial metastatic prostate cancer. Methods: A total of 249,331 prostate cancer patients who were diagnosed between 2010 and 2014 in SEER database

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Su, ChunXia, Juan Zhou, Xiangling Chu, and Jing Zhao. "Genetic mutations associated with lung cancer metastasis to the brain." Journal of Global Oncology 5, suppl (2019): 41. http://dx.doi.org/10.1200/jgo.2019.5.suppl.41.

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41 Background: Lung cancer is the most common cause of mortality in both men and women, accounting for one-quarter of all cancer deaths. Most lung cancer-associated deaths result from metastasis, especially brain metastasis. Metastasis associated mutations are important biomarkers for metastasis prediction and outcome improvement. The current study aimed to reveal the molecular mechanisms and the genetic alterations involved in metastasis from lung tumors to the brain. Methods: We carried out whole exome sequencing (WES) of the primary tumors and the corresponding brain metastases from 15 pati

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Ikram, Chamtouri, Amdouni Nesrine, Kaddoussi Rania, et al. "Case Report: Mitral valve obstruction by metastatic malignant phyllodes tumor." F1000Research 11 (July 25, 2022): 309. http://dx.doi.org/10.12688/f1000research.110022.2.

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Cardiac metastases are rare. Herein, we report a case of a 37-year-old female patient with a history of borderline breast phyllodes tumor (PT) treated by surgery, admitted to our department for concomitant cardiac and pulmonary metastases of malignant PT. Cardiac metastasis occurred through direct extension from pulmonary metastasis to the left atrium via the right inferior pulmonary vein, causing severe mitral valve obstruction. Although the total surgical removal of metastases, the patient had a huge relapse of the mediastinal metastasis resulting in her death.

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Zanib Javed, Raheema Sadiq, Hania Fatima, and Muhammad Shahzad Shamim. "Intramedullary Spinal Cord Metastasis in Spinal Ependymomas." Journal of the Pakistan Medical Association 75, no. 03 (2025): 509–11. https://doi.org/10.47391/jpma.25-22.

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Drop metastasis, or intramedullary spinal cord metastasis(ISCM), is a rare condition accounting 0.9%–5% of CNS orspinal metastases. It arises from tumour cell disseminationthrough cerebrospinal fluid (CSF), often affecting thethoracic and lumbar spine. Clinical features include rapidlyprogressive neurological deficits, limb weakness, sensoryloss, and pain. Diagnosing drop metastasis is challengingand MRI with gadolinium remains the gold standardmodality for investigation. Surgical resection followed byradiotherapy remains the primary treatment option,whereas chemotherapy serves a palliative ro

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Gusho, Charles A., Alan T. Blank, and Marta Batus. "Outcomes of brain metastasis in high-grade bone and soft tissue sarcoma: An analysis of clinicopathological characteristics and survival data." Rare Tumors 13 (January 2021): 203636132110261. http://dx.doi.org/10.1177/20363613211026151.

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Brain metastases in sarcoma are exceedingly rare, with few published series documenting ranges from 1% to 8%. This study investigated the outcomes of sarcoma patients with brain metastases using a population-based analysis. This was a retrospective review of 5933 patients with high-grade sarcoma identified from the Surveillance, Epidemiology, and End Results database between 2010 and 2015. Of the eligible 5933 patients, 0.7% ( n = 44) had brain metastasis. Kaplan–Meier was used to estimate survival and follow-up (reverse Kaplan–Meier), and a multivariable Cox proportional hazards model analyze

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Takayanagi, Akio, Atsushi Takahashi, Wakako Yorozuya, Kou Okabe, Tomohito Kaji, and Yoshio Takagi. "The Usefulness of Positron Emission Tomography/Computed Tomography in the Diagnosis of Metastasis in Patients with Urothelial Carcinoma — A Secondary Publication." Urology Research 2, no. 1 (2024): 7–12. http://dx.doi.org/10.26689/ur.v2i1.6504.

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Purpose: This study examined the usefulness of positron emission tomography (PET)/computed tomography (CT) in the diagnosis of metastasis in patients with urothelial carcinoma. Materials and methods: The subjects were patients who were newly diagnosed with urothelial carcinoma in our department on whom we performed CT and PET/CT to search for metastasis. Results: The median age of the 92 subjects was 71 years, and bladder and upper tract urothelial cancer were underlying diseases in 41 (46%) and 51 (54%) patients, respectively. In 66 (72%) of the 92 cases, no metastasis was observed by CT, whi

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Tani, Shoichiro, Yutaka Morizaki, Kosuke Uehara, et al. "Bone metastasis of limb segments: Is mesometastasis another poor prognostic factor of cancer patients?" Japanese Journal of Clinical Oncology 50, no. 6 (2020): 688–92. http://dx.doi.org/10.1093/jjco/hyaa024.

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Abstract Objective In contrast to acrometastasis, defined as bone metastasis to the hand or foot, the frequency and prognosis of bone metastasis of other limb segments remain unclear. To compare prognosis according to sites of bone metastasis, we defined two new terms in this study: ‘mesometastasis’ and ‘rhizometastasis’ as bone metastasis of ‘forearm or lower leg’ and ‘arm or thigh’, respectively. Methods A total of 539 patients who were registered to the bone metastasis database of The University of Tokyo Hospital from April 2012 to May 2016 were retrospectively surveyed. All patients who we

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Elmesidy, Salah Eldeen, Mahmoud Abdelsalam, and Husam Zawam. "Brain metastasis in a series of NSCLC: Egyptian experience." Journal of Clinical Oncology 30, no. 15_suppl (2012): e18001-e18001. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e18001.

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e18001 Background: Incidence of cerebral metastasis is increasing among lung cancer patients. Many factors have been reported associated with increase risk of brain metastasis. The aim of this retrospective analysis is to investigate the predictive factors for the development of brain metastasis in lung cancer patients. Methods: We retrospectively analyzed histologically proven lung cancer patients radiologically diagnosed of having brain metastases who presented to Kasr Al-Eini Center for Oncology (NEMROCK) in the period from 2004 till 2010, with follow up period of 6 months at least. The fol

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Ahmed, Mohamed E., Jack R. Andrews, Ahmed Mahmoud, et al. "Survival patterns based on site-specific visceral metastasis in patients with metastatic prostate cancer: Are outcomes of visceral metastases the same?" Journal of Clinical Oncology 41, no. 6_suppl (2023): 269. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.269.

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269 Background: Metastatic visceral involvement in prostate cancer patients conveys a poor prognosis. Survival patterns of site-specific visceral metastasis are poorly understood. Here, we sought to investigate survival patterns in prostate cancer patients according to their first detected site of visceral metastasis. Methods: Retrospectively, we identified 200 patients with visceral metastatic prostate cancer. Patients were divided into three groups according to first site detected with visceral metastases; first-site lung metastases, first-site brain metastases, and first-site liver metastas

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Zhang, Peng, Weili Yang, Yingfeng Fu, et al. "Is lymph node metastasis an event indicating an advanced gastrointestinal stromal tumor?" Journal of Clinical Oncology 42, no. 3_suppl (2024): 754. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.754.

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754 Background: The clinicopathological features and prognosis of gastrointestinal stromal tumors (GISTs) with lymph node metastasis remain controversial owing to their low incidence. A multicenter retrospective cohort study was conducted to compare the clinicopathological features and oncologic outcomes of GIST with and without lymph node metastases. Methods: The medical records of patients with GISTs in 16 large medical centers in China from January 2014 to December 2020 were reviewed. Patients were divided into three groups: no metastasis, lymph node metastasis without distant metastasis, a

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Tantraworasin, Apichat, Somcharoen Saeteng, Nirush Lertprasertsuke, Nuttapon Arayawudhikule, Choosak Kasemsarn, and Jayanton Patumanond. "Completely Resected N0 Non-Small Cell Lung Cancer: Prognostic Factors Affecting Long-Term Survival." ISRN Surgery 2013 (August 29, 2013): 1–7. http://dx.doi.org/10.1155/2013/175304.

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Background. Although early stage non-small cell lung cancer (NSCLC) has an excellent outcome and correlated with good long-term survival, up to 15 percent of patients still relapse postoperatively and die. This study is conducted to identify prognostic factors that may affect the long-term survival in completely resected N0 NSCLC. Methods. Medical records of 124 patients with completely resected N0 NSCLC were retrospectively reviewed. Prognostic factors affecting long-term survival were analyzed by the Kaplan-Meier method and Cox proportional hazards analysis. Results. Overall five-year surviv

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Zuccato, Jeffrey, Yasin Mamatjan, Kenneth Aldape, and Gelareh Zadeh. "ECOA-8. Lung adenocarcinoma brain metastasis prediction using tumor DNA methylation profiling." Neuro-Oncology Advances 3, Supplement_2 (2021): ii2. http://dx.doi.org/10.1093/noajnl/vdab070.008.

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Abstract Introduction The development of brain metastases from primary cancer profoundly impacts patient prognosis. Up to one quarter of lung cancers develop brain metastases and subsequent median overall survival is one year. Although clinical factors do not reliably predict brain metastasis development, DNA methylation signatures have been recently shown to predict outcomes in other cancers. It is hypothesized that DNA methylation signatures predicting brain metastasis development from lung cancer will be identified. This work may allow for treatment strategies that prevent brain metastasis

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Decoene, Jasper, Filip Ameye, Evelyne Lerut, Raymond Oyen, Hein Van Poppel, and Steven Joniau. "Renal Cell Carcinoma with Synchronous Metastasis to the Calcaneus and Metachronous Metastases to the Ovary and Gallbladder." Case Reports in Medicine 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/671645.

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Renal cell carcinomas (RCCs) are known for their unpredictable metastatic pattern. We present the case of a 63-year-old woman who initially presented in 1992 with a metastasis in the left calcaneus that led to the discovery of RCC. In 1998, a new metastasis was found in the ovary. In 2008, the diagnosis of a gallbladder metastasis was made. All metastases were surgically removed; no additional systemic therapies were used. Aggressive surgical treatment can prolong the survival of patients with resectable metastases. Patterns of metastasis are discussed, and a brief review of the literature is

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Kandagatla, Pridvi, Lilias H. Maguire, and Karin M. Hardiman. "Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies." European Surgical Research 59, no. 5-6 (2018): 361–70. http://dx.doi.org/10.1159/000494832.

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Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical t

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Kadi, N., M. Isherwood, M. Al-Akraa, and S. Williams. "Port-Site Metastasis after Laparoscopic Surgery for Urological Malignancy: Forgotten or Missed." Advances in Urology 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/609531.

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Purpose. Port-site metastasis has been a concern with the common use of laparoscopy in urologic oncology. We conducted this study to provide a review of port-site metastases reported after the laparoscopy in managing urologic malignancies, possible contributing factors and preventative measures.Materials and Methods.An electronic search of MEDLINE using the combined MESH key words “port-site metastasis” and “Urology”.Results. 51 articles addressing port-site metastasis after laparoscopic surgery for urolo¬gical malignancy were identified.Conclusion. Port-site metastasis after laparoscopic surg

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Jajja, Salman Ayub, Syed Arsalan Ahmed Naqvi, Muhammad Ali Khan, et al. "Survival in advanced prostate cancer (PCa) patients with visceral metastasis: A population-based SEER study." Journal of Clinical Oncology 43, no. 5_suppl (2025): 134. https://doi.org/10.1200/jco.2025.43.5_suppl.134.

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134 Background: Prostate cancer patients with visceral metastases at diagnosis are often treated using one-size-fits-all approach. For example, CHAARTED criteria treats any visceral metastasis as high volume. Therefore, we aimed to assess overall survival (OS) by site of visceral involvement in patients with metastatic PCa. Methods: Surveillance, Epidemiology, and End Results (SEER) database (2010-2021) was queried to obtain case listing data on metastatic PCa patients from 17 registries. The patients were categorized into three groups based on visceral metastasis at diagnosis: lung metastasis

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Langley, Robert R., and Isaiah J. Fidler. "The Biology of Brain Metastasis." Clinical Chemistry 59, no. 1 (2013): 180–89. http://dx.doi.org/10.1373/clinchem.2012.193342.

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BACKGROUND It is estimated that at least 200 000 cases of brain metastases occur each year in the US, which is 10 times the number of patients diagnosed with primary brain tumors. Brain metastasis is associated with poor prognosis, neurological deterioration, diminished quality of life, and extremely short survival. Favorable interactions between tumor cells and cerebral microvascular endothelial cells encourage tumor growth in the central nervous system, while tumor cell interactions with astrocytes protect brain metastases from the cytotoxic effects of chemotherapy. CONTENT We review the pat

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Zhang, Luyan, Xifa Wu, Yong Feng, Linlin Zheng, and Jinbo Jian. "Selenium donors inhibits osteoclastogenesis through inhibiting IL-6 and plays a pivotal role in bone metastasis from breast cancer." Toxicology Research 9, no. 4 (2020): 544–51. http://dx.doi.org/10.1093/toxres/tfaa053.

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Abstract Bone metastases are a frequent complication of breast cancer, and there has been little progress in the treatment of breast cancer patients with bone metastases. The cytotoxicity of selenium donors, including organic selenium and selenium nanoparticles (SeNPs), to cancer cells has been reported previously, but their relationship with bone metastases progression is not fully clear yet. In this study, multicenter clinical exploration was conducted to obtain dietary selenium intakes of breast cancer patients with or without bone metastasis, to study the relationship between selenium and

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Arici, Akgul. "Clinicopathological features of our renal cell carcinoma metastasis cases: A single-center experience." Medicine Science | International Medical Journal 12, no. 4 (2023): 1140. http://dx.doi.org/10.5455/medscience.2023.08.158.

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Renal cell carcinoma (RCC) is the most common renal tumor in adults, arising from renal tubular epithelial cells. Approximately 30% of patients with RCC have metastases at the time of diagnosis, while metastases can be seen in 40% of patients during follow-up after nephrectomy. Metastases most commonly occur in the lung, bone, and lymph nodes. In our study, we aimed to retrospectively examine the cases diagnosed with RCC metastasis and evaluate their clinicopathological features. Age, gender, metastasis site, number of metastatic foci, localization of primary kidney tumor, histopathological ty

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Fendt, Sarah-Maria. "Abstract PL04-03: Metastasis aggressiveness: A function of metabolite signaling." Cancer Research 84, no. 7_Supplement (2024): PL04–03—PL04–03. http://dx.doi.org/10.1158/1538-7445.am2024-pl04-03.

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Abstract Metastasis formation is the leading cause of death in cancer patients. Yet, the molecular mechanisms responsible for the aggressiveness of metastases remain largely unknown. We used experimental metastasis mouse models and samples from patients with breast cancer to study metastases aggressiveness. We discovered that the aggressiveness of cancer cells in lung metastases was driven by an alternative translational program that was regulated by metabolite signaling. Strikingly, the identified molecular mechanism could be disrupted by repurposing a clinical approved inhibitor, which resul

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He, Chunyu, Guliqihere Mamuti, Munire Mushajiang, and Simayili Maimatiniyazi. "Risk factors and prognostic factors of brain metastasis of triple-negative breast cancer: A single-center retrospective study." Journal of Cancer Research and Therapeutics 20, no. 4 (2024): 1314–22. http://dx.doi.org/10.4103/jcrt.jcrt_2079_21.

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ABSTRACT Objective: This retrospective study is to explore the risk factors and prognostic factors of brain metastases of triple-negative breast cancer (TNBC) in a single center. Methods: Clinical data of patients with stages I–III TNBC were collected. The Kaplan-Meier method, log-rank test, and stepwise COX regression were performed. Results: The 437 patients with stages I–III TNBC were followed up for five years. Among them, 89 cases (20.4%) developed brain metastases, and they were followed up for 2 years after brain metastasis. The cumulative brain metastasis rates of TNBC patients at six

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Yakar, Melek, and Durmuş Etiz. "Prognostic factors of breast cancer brain metastasis." World Journal of Clinical Oncology 15, no. 1 (2024): 5–8. http://dx.doi.org/10.5306/wjco.v15.i1.5.

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In this editorial we comment on the article by Chen et al published in the recent issue of the World Journal of Clinical Oncology . Brain metastasis is one of the most serious complications of breast cancer and causes high morbidity and mortality. Brain metastases may involve the brain parenchyma and/or leptomeninges. Symptomatic brain metastases develop in 10%-16% of newly recognized cases each year, and this rate increases to 30% in autopsy series. Depending on the size of the metastatic foci, it may be accompanied by extensive vasogenic edema or may occur as small tumor foci. Since brain me

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Zuccato, Jeffrey, Yasin Mamatjan, Kenneth Aldape, and Gelareh Zadeh. "CMET-32. DNA METHYLATION ALTERATIONS IN LUNG ADENOCARCINOMAS THAT DEVELOP BRAIN METASTASES." Neuro-Oncology 21, Supplement_6 (2019): vi58. http://dx.doi.org/10.1093/neuonc/noz175.233.

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Abstract INTRODUCTION The development of brain metastases from primary cancer profoundly impacts patient prognosis. Metastases are the most common adult brain tumor with up to one quarter of lung cancers developing metastases and median overall survival after metastasis being one year. Clinical factors do not reliably predict brain metastasis development and over 90% are identified after symptoms develop. DNA methylation signatures predict outcomes in other cancers and so identifying signatures that predict metastasis development may allow for treatment strategies that prevent development in h

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Casado, Crystal, Sydney Caputo, Ellen B. Jaeger, et al. "Genomic alterations in patients with prostate cancer with liver metastases." Journal of Clinical Oncology 41, no. 6_suppl (2023): 248. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.248.

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248 Background: mCRPC patients with liver metastases have a poor prognosis and often progress rapidly on a variety of treatments. Previously, preliminary ctDNA analyses of mCRPC patients with liver metastases showed a range of commonly altered genes in patients with liver metastases (Ranasinghe et al; 2019). In this follow-up, we evaluated ctDNA alterations in an expanded cohort of mCRPC patients with liver metastases. Methods: From Tulane Cancer Center, retrospective review of mCRPC patients was used to identify patients with confirmed liver metastasis. All liver metastases were confirmed bas

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