Log in

Relevant bibliographies by topics / Metastatic cancer / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Metastatic cancer.

Dissertations / Theses on the topic 'Metastatic cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Metastatic cancer.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Wander, Seth A. "p27 and Metastatic Progression: Molecular Mechanisms Underlying Bone Metastasis." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/690.

Full text

Abstract:

The complex PI3K/mTOR pathway regulates tumor progression via effects on cellular proliferation, apoptosis, autophagy, and motility. New drugs that inhibit the catalytic site of both PI3K and mTOR have shown promise in clinical trials. Here, we report the first use of a novel, dual PI3K/mTOR catalytic site inhibitor (PF-04691502, PF1502) in a xenograft model of breast cancer metastasis to bone. Metastatic MDA-MB-1833 cells showed PI3K/mTOR activation relative to parental MDA-MB-231. Low-dose PF1502 significantly impaired tumor cell motility and invasion in vitro without causing cell cycle arre

APA, Harvard, Vancouver, ISO, and other styles

2

Nordman, Ina IC Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Surrogate endpoints of survival in metastatic carcinoma." Publisher:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/42791.

Full text

Abstract:

In most randomised controlled trials (RCTs), a large number of patients need to be followed over many years, for the clinical benefit of the drug to be accurately quantified (1). Using an early proxy, or a surrogate endpoint, in place of the direct endpoint of overall survival (OS) could theoretically shorten the duration of RCTs and minimise the exposure of patients to ineffective or toxic treatments (2, 3). This thesis examined the relationship between surrogate endpoints and OS in metastatic colorectal cancer (CRC), advanced non-small cell lung cancer (NSCLC) and metastatic breast cancer (M

APA, Harvard, Vancouver, ISO, and other styles

3

Solberg, Arne. "Outcome Assessments in Non- Metastatic Prostate Cancer." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kreftforskning og molekylær medisin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-13881.

Full text

Abstract:

Metoder for å måle utfall av behandling hos pasienter med prostatakreft uten spredning. Prostatakreft uten påvist spredning kan behandles med operasjon, strålebehandling med eller uten hormonbehandling, eller hormonbehandling alene. Svært mange menn med nylig påvist prostatakreft vil imidlertid kunne leve i mange år uten plager av sykdommen også uten behandling, og en stor andel dør til slutt av helt andre årsaker enn prostatkreft. Man mangler imidlertid helt sikre metoder for å velge ut pasienter som ikke trenger behandling, men i noen tilfeller hvor sykdommen er i tidlig fase er et regelmess

APA, Harvard, Vancouver, ISO, and other styles

4

Paon, Lenaic Marie Pierre. "Gene expression profiling of metastatic gastric cancer." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490659.

Full text

Abstract:

Gastric cancer is one of the main cancers in the world, and is responsible for a large number of deaths each year. In Europe, the main issue is that it is only detected at latter stages, when metastases have developed. Although metastasis is the main cause of death from such tumours, the process is a very complex one and still not fully understood. In order to unravel this mechanism, microarrays have been used to study the expression pattern of a large number of genes in primary tumours and metastatic samples. These studies aim at indentifying genes that may playa role in metastasis. A number

APA, Harvard, Vancouver, ISO, and other styles

5

Pelon, Floriane. "Fibroblastic heterogeneity and metastatic spread in breast cancers Fibroblast heterogeneity drives metastatic spread in breast cancer through distinct mechanisms." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2392&f=17330.

Full text

Abstract:

Les cancers du sein, premiers cancers féminins et causes aujourd’hui encore de nombreux décès, sont classés en 3 sous-types moléculaires : luminaux –les plus répandus, HER2 et triple-négatifs (TN) –les plus agressifs. Lors du diagnostic, l’envahissement des ganglions lymphatiques axillaires par les cellules tumorales est établi. Il s’agit, en plus de la classification moléculaire, d’un marqueur pronostique utilisé en clinique pour stratifier les patientes, car il informe sur le risque de développement ultérieur de métastases, cause majeure des décès à l’heure actuelle. Les tumeurs solides, et

APA, Harvard, Vancouver, ISO, and other styles

6

Chiang, Yan Ting. "Identification of metastasis-driving genes as potential therapeutic targets/ biomarkers for metastatic prostate cancer." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52901.

Full text

Abstract:

Metastatic prostate cancer is currently incurable. Metastasis is thought to result from changes in the expression of specific metastasis-driving genes, leading to a cascade of activated downstream genes setting the metastatic process in motion. As such, metastasis-driving genes could provide effective therapeutic targets and prognostic biomarkers for improved disease management. In search of potential metastasis-driving genes, genes with elevated expression in patient-derived metastatic LTL-313H prostate cancer tissues, as distinct from non-metastatic LTL-313B tissues, were identified. Among t

APA, Harvard, Vancouver, ISO, and other styles

7

Nielsen, S. R. "Metastasis-associated macrophages orchestrate the formation of a hospitable metastatic niche in pancreatic cancer." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3007527/.

Full text

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with an overall 5-year survival rate < 5%, a rate that has not improved for a long time. The dismal prognosis for PDAC is part due to late detection, often at advanced stages of the disease where patients have developed distant metastases, but also due to chemotherapeutical resistance. Patients eligible for surgical resection of the pancreatic tumour has the best prognosis, but even when resection is successful, patients often relapse with distant metastases within 2 years after surgery. Macrophages promote tumourigenesi

APA, Harvard, Vancouver, ISO, and other styles

8

Reed, Elizabeth. "The experience of living with metastatic breast cancer." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/344746/.

Full text

Abstract:

Over the last 10-15 years the medical management of metastatic breast cancer has improved survival, so women are living longer with progressive disease. Little is understood about women’s problems and needs and how they live their everyday lives. This study aimed to explore the experience of women with metastatic breast cancer by applying three phases: a cross-sectional survey exploring quality of life, experience of care and where they turned for support; exploration of the narratives of 30 women considering the social consequences of living with progressive breast cancer on identity; and fin

APA, Harvard, Vancouver, ISO, and other styles

9

He, Felicia Jane. "Targeting Metastatic Breast Cancer Using Dual-Ligand Nanoparticles." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499699087340348.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Donald, Carlton Dewitt. "Metastatic characteristics of tumor progression in Prostate Cancer." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1995. http://digitalcommons.auctr.edu/dissertations/3299.

Full text

Abstract:

Tumor biologist have long appreciated that both cell to cell and cell to extracellular matrix (ECM) interactions are involved in the invasive and metastatic events that are characteristic of malignancy. Cancer cell attachment to and invasion of an ECM has been associated with metastatic potential of cell lines of the Dunning rat prostate model. It was postulated that differences observed in the metastatic potential of four Dunning cell lines may correlate with cell-matrix interactions. Four cell lines, highly metastatic ML, MLL, AT-3 and non-metastatic AT-1 were studied. The adhesive, invasive

APA, Harvard, Vancouver, ISO, and other styles

11

Loughlin, Paula Mary. "Immune responses in primary and metastatic breast cancer." Connect to e-thesis, 2009. http://theses.gla.ac.uk/877/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Menssouri, Naoual. "Genomic Profiling Of Metastatic Castration-Resistant Prostate Cancer." Thesis, université Paris-Saclay, 2022. http://www.theses.fr/2022UPASL099.

Full text

Abstract:

Le cancer de la prostate est le cancer le plus fréquent et constitue la troisième cause de décès par cancer chez l'homme dans les pays industrialisés. Le traitement systémique de première intention des formes métastatiques consiste en une thérapie de déprivation androgénique par castration chirurgicale ou médicamenteuse. Le cancer de la prostate métastatique résistant à la castration (mCRPC) est considéré comme incurable. Son traitement repose sur de la chimiothérapie ou des inhibiteurs de la voie du récepteur des androgènes (ARPIs) tels que l'enzalutamide ou l'abiratérone. Même si les ARPIs s

APA, Harvard, Vancouver, ISO, and other styles

13

Shehata, Sara <1993&gt. "Synthesis of Anti-Metastatic Agent for Cancer Theraphy." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/13854.

Full text

Abstract:

Breast cancer is the most common cancer in women worldwide and is the cause of millions of deaths around the world each year. The majority of breast cancer related mortalities are a result of metastatic disease involving the formation of secondary tumours where cancer cells have spread from the primary tumour to sites around the body. Among the most difficult to treat are those which belong to the basal-type, or triple-negative intrinsic molecular class as these lack the three key hormone receptors: oestrogen (ER), progesterone (PGR) and human epithelial receptor 2 (Her2) which are the targets

APA, Harvard, Vancouver, ISO, and other styles

14

Charnley, Richard Michael. "The early detection of recurrent and metastatic colorectal cancer." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277384.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Iamshanova, Oksana. "Role of NALCN channel in prostate cancer metastatic behaviours." Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10205.

Full text

Abstract:

L’homéostasie sodique joue un rôle prépondérant lors de la carcinogénèse prostatique. Cependant, le rôle du canal de fuite sodique NALCN lors de la carcinogénèse prostatique était totalement inconnu. L’objectif principal de cette étude était d’étudier le rôle de NALCN dans la dérégulation de l’homéostasie sodique lors de la tumorigenèse prostatique. Tout d’abord, nous avons montré sur des coupes de tissus prostatiques que l’expression de NALCN est augmentée dans les cancers. De plus, NALCN est surexprimé dans les lignées cancéreuses prostatiques les plus agressives. Nous avons vérifié la fonct

APA, Harvard, Vancouver, ISO, and other styles

16

James, Mark Ian. "Treatment of metastatic colorectal cancer : a role for curcumin?" Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/32351.

Full text

Abstract:

Colorectal cancer remains the third largest cause of mortality from cancer related death, with approximately 90% of these deaths attributed to metastatic spread of the disease. There is a need to improve chemotherapy, with the dietary polyphenol curcumin, derived from turmeric, representing a potential candidate as it possess very few side effects and it has shown efficacy in mouse models. Recent advances in our understanding of tumour development have highlighted the existence of tumour initiating cells (TIC), which possess clonogenic potential, are essential for tumour growth, and represent

APA, Harvard, Vancouver, ISO, and other styles

17

Fulton, Colette Louise. "The rehabilitation needs of women with metastatic breast cancer." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19769.

Full text

Abstract:

Each year approximately 26,000 British women develop breast cancer and 16,000 die from their disease. Breast cancer is the most common cancer in women in the United Kingdom. Previously, most studies have focused on the needs of women following surgery for the treatment of primary breast cancer. However, few systematic studies have monitored the needs of women with metastatic disease. The median survival of women with metastatic breast cancer is 19 months and therefore it would seem appropriate to monitor the rehabilitation needs of these women. This study examines the physical, psychological,

APA, Harvard, Vancouver, ISO, and other styles

18

Gross, Brett Patrick. "Therapeutic vaccination for the treatment of metastatic breast cancer." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6119.

Full text

Abstract:

Metastatic breast cancer is a leading cause of cancer-related mortality worldwide. While existing interventions are effective at treating localized tumors, disseminated malignancies remain incurable. Vaccine-induced anti-tumor immunity is a promising approach for treating disseminated tumors, as immune responses are systemic, have antigen-restricted cytotoxicity, and generate protective immune “memory” populations. Our group has developed a novel heterologous prime/boost vaccine protocol that treats

APA, Harvard, Vancouver, ISO, and other styles

19

Gooding, Alex Joseph. "Characterizing a Role for the lncRNA BORG during Breast Cancer Progression and Metastasis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1528462540265762.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Kwok, Mon-sze, and 郭夢思. "Study of metastatic suppressing genes on ovarian carcinomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010729.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Lee, Yee-ki Carol, and 李綺琪. "Effect of dietary fatty acids on metastatic hepatocellularcarcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39707349.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Péladeau, Christine. "Isoform Specific Function of the Metastatic Formin FMNL2." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24396.

Full text

Abstract:

Cancer cell metastasis is induced by actin-dependent cell migration and is affected by cytoskeletal remodelling proteins. FMNL2 is one such protein which promotes colorectal cancer (CRC) cell metastasis and amoeboid style invasion of melanoma cells. FMNL2 mRNA is subject to alternative splicing and studies suggest that the resulting encoded proteins are likely to differ in their regulation, subcellular localization and activity. We identified four FMNL2 isoforms (ITM, YHY, PMR and TQS) expressed in non-invasive (SW480) and invasive (SW620) CRC cells, as well as in highly invasive A375 amoeboid

APA, Harvard, Vancouver, ISO, and other styles

23

Malek, Joël. "Genetic alterations of the metastatic lesions in ovarian carcinoma." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T109.

Full text

Abstract:

Le cancer de l’ovaire est le cancer gynécologique avec la plus grande mortalité due à un diagnostique tardif au stade de maladie extensive péritonéale. Malgré les progrès de la chirurgie radicale et de la chimiothérapie les récurrences abdominales demeurent la cause la plus fréquente de mortalité. Il existe peu d’études de la maladie métastatique péritonéale. Notre hypothèse de travail est que les différences entre la maladie métastatique et la tumeur primaire sont primordiales dans la survenue d’une maladie résiduelle ou récurrente. Nous avons utilisé une approche exhaustive comprenant des ét

APA, Harvard, Vancouver, ISO, and other styles

24

Halse, Héloïse. "The Immunopathology of Primary and Metastatic tumors of the Liver." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL126.

Full text

Abstract:

L'immunothérapie anti-cancéreuse est un traitement efficace chez certains patients, mais cela dépend de l'organe atteint. Les patients avec un cancer du foie primitif ou des métastases hépatiques d'un cancer colorectal (MHCCR) ont souvent des réponses limitées. Cela est lié à l’environnement immunitaire particulier du foie. Dans cette étude, nous avons examiné l’impact des cellules immunitaires dans le MHCCR, en particulier les mastocytes et les neutrophiles, dans la survie. La présence accrue de mastocytes était liée à un meilleur pronostic, tandis que la présence de neutrophiles était associ

APA, Harvard, Vancouver, ISO, and other styles

25

Frieling, Jeremy S. "Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6841.

Full text

Abstract:

Skeletal metastasis is a lethal component of many advanced cancers including prostate, the second most common cancer among men. Patients whose prostate cancer is localized and detected early benefit from multiple treatment options ranging from active surveillance to radiation and surgery, resulting in a 5-year survival rate of nearly 100%. Unfortunately, the prognosis and survival for patients with advanced metastatic disease is much worse due to the highly aggressive nature of the disease and a paucity of treatment options. Understanding the mechanisms and interactions that occur between m

APA, Harvard, Vancouver, ISO, and other styles

26

Conway, Brianna. "Searching for Synergy: FAK Inhibition in Metastatic Breast Cancer Treatment." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37304.

Full text

Abstract:

Breast cancer is the most common cancer among Canadian women and 14-20% will develop lethal metastases within 5 years. A potential novel therapeutic target is Focal Adhesion Kinase (FAK), a cytoplasmic tyrosine kinase. FAK’s expression is inversely correlated with survival and is known to regulate cell migration, proliferation and invasion. While tyrosine kinase inhibitors are historically ineffective as single agents, they are commonly used as part of combination therapies. Therefore, given its central role in tumor cell biology and cell signaling, we hypothesized that inhibiting FAK in comb

APA, Harvard, Vancouver, ISO, and other styles

27

Alsulaiman, Abdullah. "Investigation of the role of CD24 in metastatic colorectal cancer." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/55401/.

Full text

Abstract:

CD24 is a small (81 amino acids) GPI anchored protein which is involved in promoting cell motility and stemness and may be a part of the metastatic process. It is a heavily glycosylated molecule and contains numerous O-glycosylation sites together with two N-glycosylation sites. N-glycosylation is thought to be important in protein function, and therefore, the aim of this study is to (a) investigate the importance of N-glycosylation in the function of CD24, (b) identify other potentially functional sites in CD24 by deletion mapping, (c) define downstream targets of CD24, and (d) identify the e

APA, Harvard, Vancouver, ISO, and other styles

28

Vang, Yeeleng Scott. "An Ensemble Prognostic Model for Metastatic, Castrate-Resistant Prostate Cancer." Thesis, University of California, Irvine, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10162542.

Full text

Abstract:

<p> Metastatic, castrate-resistant prostate cancer (mCRPC) is one of the most prevalent cancers and is the third leading cause of cancer death among men. Several treatment options have been developed to combat mCRPC, however none have produced any tangible benefits to patients' overall survivability. As part of a crowd-sourced algorithm development competition, participants were asked to develop new prognostic models for mCRPC patients treated with docetaxel. Such results could potentially assist in clinical decision making for future mCRPC patients. </p><p> In this thesis, we present a ne

APA, Harvard, Vancouver, ISO, and other styles

29

Roda, Ana Sofia Martins. "Nanoparticles for recognition and delivery in metastatic colorectal cancer cells." Master's thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier, 2016. http://hdl.handle.net/10362/63808.

Full text

Abstract:

"Colorectal cancer is a global health concern. The high incidence of colorectal metastasis, mainly in the liver, triggers an increase of the mortality rate and greatly reduces the effective cure chances. For this reason, the investigation in the area is now focused on efficient detection and elimination of metastasis. Nanotechnology has become a fundamental research field since it provides promising perspectives regarding specific, oriented and sustained delivery of loaded nanoparticles for nanoteragnostic approaches. The current project aims to develop a nanocarrier, strategically constructed

APA, Harvard, Vancouver, ISO, and other styles

30

Garg, Ayush A. "Electromagnetic Fields Alter the Motility of Metastatic Breast Cancer Cells." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563816767104018.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Mitchell, Jill Laurin. "Construction of meaning in women's experiences with metastatic breast cancer." Diss., Restricted to subscribing institutions, 2006. http://proquest.umi.com/pqdweb?did=1251832051&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Tomlinson, James S. "Molecular basis of the metastatic phenotype of inflammatory breast cancer." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872078261&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Casey, Susan Marie. "Metastatic recurrent breast cancer : the couples' experience with role changes /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/7253.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Yee, Jasmine. "Physical well-being for women living with metastatic breast cancer." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17048.

Full text

Abstract:

Despite established benefits of exercise for early breast cancer, its role for women with metastatic disease is unknown. The broad aims of this thesis were to determine the capacity and interest for physical activity in women with metastatic breast cancer, and to use this information to develop and pilot a physical activity intervention. An additional aim was to assess the accuracy of physical activity monitors. Physical function of the metastatic population was firstly compared to a healthy cohort. Although on average women with metastasis had lower levels of fitness than healthy women, some

APA, Harvard, Vancouver, ISO, and other styles

35

BERTOCCHI, ALICE. "ROLE OF THE GUT VASCULAR BARRIER IN METASTATIC COLON CANCER." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/608839.

Full text

Abstract:

Spreading of neoplastic cells from colon cancer to regional lymph nodes (LN) is often associated with distant recurrence. However, a number of clinical trials have shown that lymphadenectomy is not increasing Colon Cancer (CC) patient’s survival. This phenomenon is probably due to a metastatic dissemination that occurs via the systemic blood circulation, rather than the lymphatic vessels. How such dissemination is achieved is unknown. We hypothesized that the disruption of the vasculature in colon tumors can be linked to cancer cells dissemination. We identified a new marker of deranged vascul

APA, Harvard, Vancouver, ISO, and other styles

36

Nordstrand, Annika. "Prostate cancer and bone cell interactions : implications for metastatic growth and therapy." Doctoral thesis, Umeå universitet, Onkologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131809.

Full text

Abstract:

The skeleton is the most common site of prostate cancer bone metastasis, and at present, there are no curable treatments for these patients. To further understand what stimulates tumor cell growth in the bone microenvironment and to find suitable therapies, reliable model systems are needed. For this purpose, we have developed an in vitro co-culture system that can be used to study interactions between tumor cells and murine calvarial bones. To validate the model, we measured the release of collagen fragments and monitored changes in expression levels of genes normally expressed during active

APA, Harvard, Vancouver, ISO, and other styles

37

Reedy, Jessica Leigh. "Pyridinium derivatives for metastatic melanoma therapy." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/6628.

Full text

Abstract:

Melanoma incidence is increasing faster than any other cancer worldwide.1 Early detection is often curative, but metastatic melanoma is lethal (5-year survival <20%) due to the development of resistance to all approved drugs.1 However, emerging evidence suggests that differences in melanoma metabolism relative to non-malignant cells may provide a target to improve treatment.2-14 Specifically, melanoma cells have increased mitochondrial electron transport chain (ETC) activity, elevated levels of reactive oxygen species, and a simultaneous hyperpolarized mitochondrial membrane potential relative

APA, Harvard, Vancouver, ISO, and other styles

38

Wen, Wucheng. "Development and Evaluation of Nano-herbal Therapy for Metastatic Breast Cancer Treatment." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/534260.

Full text

Abstract:

Pharmaceutical Sciences<br>Ph.D.<br>Triptolide (TPL), a diterpenoid triepoxide that is extracted from a traditional Chinese herb called Tripterygium Wilfordii (also known as ‘Thunder God Vine’) has recently drawn increasing interests from pharmaceutical and biomedical researchers, especially in the aspect of its potential efficacy on multiple cancer treatment. TPL has shown significant growth and proliferation inhibition activities in a broad range of cancer cell types. Moreover, it has shown the inhibition of osteoclastogenesis by breast cancer bone metastasis. However, due to its limitation

APA, Harvard, Vancouver, ISO, and other styles

39

Del, Pozo Martin Y. "The mesenchymal status of metastatic cancer cells promotes a stromal crosstalk leading to epithelial re-acquisition and metastatic colonisation." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1473399/.

Full text

Abstract:

Solid epithelial tumours are complex structures in which the associated stroma supports cancer cells (Quail and Joyce, 2013). During metastatic progression, cancer cells disseminate from their tissue of origin and recapitulate the tumour structure at distant organs, including the stromal compartment. Metastasis initiating cells (MICs) are functionally discriminated among the bulk of cancer cells for their high ability to establish metastasis (Malanchi et al., 2012, Baccelli et al., 2013). Additionally, efficient metastasis requires the expression of specific molecules within the local microenv

APA, Harvard, Vancouver, ISO, and other styles

40

Crnalic, Sead. "Metastatic spinal cord compression in prostate cancer : clinical and morphological studies." Doctoral thesis, Umeå universitet, Ortopedi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54461.

Full text

Abstract:

Background: Bone metastases occur in most patients with advanced hormone-refractory prostate cancer causing pain, pathologic fractures, and spinal cord compression. Few studies specifically address surgical treatment of metastatic spinal cord compression (MSCC) in prostate cancer. Criteria for identifying patients who may benefit from surgery are poorly defined. Most of the current knowledge regarding tumor biology in prostate cancer is based on studies of primary tumors or soft tissue metastases. The mechanisms regulating growth of bone metastases are not fully established. Aims: a) to evalua

APA, Harvard, Vancouver, ISO, and other styles

41

Keskin, Doruk. "Functional Contribution of PDGFRbeta+ Cells in Angiogenesis and Metastatic Breast Cancer." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11085.

Full text

Abstract:

Tumor stroma is known to affect tumor growth and metastasis. Inhibiting PDGF signaling, with the goal of depleting PDGFRβ+ stromal cells, is a putative therapeutic approach in this context. PDGFRβ is widely accepted as a pericyte marker and targeting PDGF signaling primarily affects pericytes. Pericyte-endothelial cell interactions modulate angiogenesis and vascular stability in developmental and pathological contexts. Owing to this, pericytes are speculated to be important regulators of tumor growth and metastasis, although their role is not clear.

APA, Harvard, Vancouver, ISO, and other styles

42

McBride, John William. "A bio-inspired gene therapy approach to treat metastatic prostate cancer." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678937.

Full text

Abstract:

Five DBVs were synthesized, expressed, purified, and complexed with plasmid DNA for analysis using a range of physicochemical and biological assays. Four of the vectors (RMHT, RM3GT, T-RMG, and T-RMR) formed cationic nanoparticles with plasmid DNA, and were capable of transfecting prostate cancer cells. Conversely RMGT formed highly cytotoxic anionic particles incapable of transfecting cells. RMHT was the most promising vector as it protected the cargo from serum and facilitated specific delivery into castrate resistant prostate cancer cells. RAT, a fusogenic peptide, is composed of an arginin

APA, Harvard, Vancouver, ISO, and other styles

43

Pinto, Pedro Miguel Teixeira. ""Comparison of Methodologies for Kras Mutation Detection in Metastatic Colorectal Cancer"." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/20041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Bradbury, Robyn. "The interplay between MDM2 and PSMA in metastatic breast cancer cells." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/100068/.

Full text

Abstract:

Both mouse double minute (MDM2) and prostate-specific membrane antigen (PSMA) are known to be associated with the progressive properties of cancer. Moreover, overexpression of both molecules has been implicated in an increase in the proliferation, migration and invasion of tumour cells. MDM2 is a negative regulator of tumour suppressor of p53 but also is known to play multiple p53-independent roles in many cancer types. PSMA was originally thought to be solely expressed in prostate tissues and overexpression prostatic cancers; however, recently its expression was reported in various other soli

APA, Harvard, Vancouver, ISO, and other styles

45

Weber, Zachary Thomas. "Applications of ctDNA Genomic Profiling to Metastatic Triple Negative Breast Cancer." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586787923790178.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Gagliardo, Camille, Megan Lybeck, and Harmony Bowles. "A Retrospective Evaluation of Eribulin Dosing Schedules in Metastatic Breast Cancer." The University of Arizona, 2016. http://hdl.handle.net/10150/613986.

Full text

Abstract:

Class of 2016 Abstract<br>Objectives: To determine the number of patients treated with eribulin who required an alternate dosing schedule other than “day 1/day 8” due to side effects. Methods: Chart reviews were conducted on all patients who met inclusion criteria. Data collected included patient demographics, history of surgery/radiation, number of past chemotherapy treatments, and lab values prior to each eribulin cycle. Results: A total of 37 patients met inclusion criteria for this study. Ten patients were initially started on the “day 1/day 8” schedule and 3 of those patients required a

APA, Harvard, Vancouver, ISO, and other styles

47

Pritchard, Rhys. "The Function of NSAIDs including Celecoxib as Therapies for Metastatic Cancer." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/389567.

Full text

Abstract:

Hypoxia is a naturally occurring event in solid tumours due to aberrant growth rates, unchecked proliferation and unregulated vascularity. Intratumoural hypoxia has been shown to contribute to malignant progression through the regulation of hypoxia-inducible factors (HIFs), transcription factors that in turn regulate a variety of stem-like and promigratory genes. Several recent meta-analyses of cancer patients administered Non-Steroidal Anti Inflammatory Drugs (NSAIDs) over the long term show a reduction in both pre and post-operative risk ratios (RR) demonstrating that NSAIDs have anti-cancer

APA, Harvard, Vancouver, ISO, and other styles

48

Pinto, Pedro Miguel Teixeira. ""Comparison of Methodologies for Kras Mutation Detection in Metastatic Colorectal Cancer"." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/20041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Schroeder, Krista Marie. "Disparities in Monoclonal Antibody Treatment of Elderly Metastatic Colorectal Cancer Patients." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/1421.

Full text

Abstract:

Multiple research studies have demonstrated racial, socioeconomic status (SES), and neighborhood disparities in first-line treatment of colorectal cancer patients, including those with metastatic colorectal cancer. However, disparities in adjunct monoclonal antibody treatment disparities have not been explored. The purpose of this study was to assess racial, SES, and neighborhood disparities in adjunct monoclonal antibody treatment of elderly metastatic colorectal cancer patients. The research was rooted in 3 theories: the fundamental cause theory, the diffusion of innovations theory, and theo

APA, Harvard, Vancouver, ISO, and other styles

50

FRANCONE, ELISA. "MiRNAs’ characterization in metastatic colorectal cancer: a multicenter prospective translational study." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1002660.

Full text

Abstract:

Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Biology and evolutive stage of the disease are responsible for prognosis, treatment and follow-up. Since in early stages 5y-OAS is close to 90% while in advanced CRC it is comprised between 12 and 17%, screening programs and preventative measures are widely adopted in an effort to anticipate the diagnosis; nevertheless, about 50-60 % of patients with CRC will develop liver metastases in the course of their disease, primary factor of long-term survival. At present, decision making depends on t

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!