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Journal articles on the topic 'Metastatic cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Yuk, Hyeong-Dong, Kyoung-Hwa Lee, Hye-Sun Lee, et al. "PDLIM2 Suppression Inhibit Proliferation and Metastasis in Kidney Cancer." Cancers 13, no. 12 (2021): 2991. http://dx.doi.org/10.3390/cancers13122991.

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We evaluated the expression of PDLIM2 in human kidney cancer cell lines from primary or metastatic origins and found that PDLIM2 expression was highly elevated in metastatic kidney cancers. We evaluated the effect of PDLIM2 inhibition by RNA interference method. PDLIM2 knockdown showed the decreased proliferation and metastatic character in human metastatic kidney cancer cells. By repeated round of orthotopic injection of RenCa mouse kidney cancer cell line, we obtained metastatic prone mouse kidney cancer cell lines. PDLIM2 expression was highly expressed in these metastatic prone cells compa

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2

Bonni, Shirin, David N. Brindley, M. Dean Chamberlain, et al. "Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment." Cancers 16, no. 5 (2024): 911. http://dx.doi.org/10.3390/cancers16050911.

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Metastasis remains a major challenge in treating breast cancer. Breast tumors metastasize to organ-specific locations such as the brain, lungs, and bone, but why some organs are favored over others remains unclear. Breast tumors also show heterogeneity, plasticity, and distinct microenvironments. This contributes to treatment failure and relapse. The interaction of breast cancer cells with their metastatic microenvironment has led to the concept that primary breast cancer cells act as seeds, whereas the metastatic tissue microenvironment (TME) is the soil. Improving our understanding of this i

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Lim, Geok Hoon, Jing Xue Hoo, You Chan Shin, Rachel Zhi Ting Choo, Fuh Yong Wong, and John Carson Allen. "Is Metastatic Staging Needed for All Patients with Synchronous Bilateral Breast Cancers?" Cancers 16, no. 1 (2023): 17. http://dx.doi.org/10.3390/cancers16010017.

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Background: Patients with bilateral breast cancers are uncommon and are associated with a poorer prognosis. While metastatic staging guidelines in patients with unilateral cancer were established, the indication of metastatic staging in patients with bilateral breast cancers is unclear. We aimed to determine which patients with synchronous bilateral breast cancers require metastatic staging at diagnosis. This is the first such reported study, to the best of our knowledge. Methods: A retrospective review of newly diagnosed synchronous bilateral invasive breast cancer patients at our institution

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Ganguly, Debolina, Marcel Schmidt, Morgan Coleman, et al. "Abstract B016: Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment." Cancer Research 83, no. 2_Supplement_2 (2023): B016. http://dx.doi.org/10.1158/1538-7445.metastasis22-b016.

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Abstract Metastatic cancer cells adapt to thrive in secondary organs. To investigate metastatic adaptation, we performed transcriptomic analysis of metastatic and non-metastatic murine breast cancer cells. We found that pleiotrophin (PTN), a neurotrophic cytokine, is a metastasis-associated factor that is expressed highly by aggressive breast cancers. Moreover, elevated PTN in plasma correlated significantly with metastasis and reduced survival of breast cancer patients. Mechanistically, we find that PTN activates NF-kB in cancer cells leading to altered cytokine production, subsequent neutrop

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Chahbounia, Imane, Saida Lamine, Khaoula Alaoui Slimani, et al. "Double Breast Neoplasia: RH+, HER2- Metastatic Left Breast Cancer and Triple Negative Metastatic Right Breast Cancer: Case Report." Scholars Journal of Medical Case Reports 12, no. 12 (2024): 2188–91. https://doi.org/10.36347/sjmcr.2024.v12i12.044.

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Breast cancer is the most common cancer in women, and the proportion of metastatic cancer is not negligible; either metastasis of a cancer that was initially localized, or metastatic disease from the outset. The case of double breast neoplasia is not exceptional; but when faced with two breast cancers, both metastatic, and with different molecular profiles, several questions arise. Case report: We report the case of a diabetic patient with localized RH+, HER2- left breast cancer treated with surgery and adjuvant chemotherapy in 2003, which became metastatic to the lung in 2022, and for which t

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Park, Jinkyung, Dahee Jeong, Meeryoung Song, and Bonglee Kim. "Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery." Antioxidants 10, no. 4 (2021): 527. http://dx.doi.org/10.3390/antiox10040527.

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Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “cancer metastasis” and “herbal medicine” as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric can

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Pein, Maren, and Thordur Oskarsson. "Microenvironment in metastasis: roadblocks and supportive niches." American Journal of Physiology-Cell Physiology 309, no. 10 (2015): C627—C638. http://dx.doi.org/10.1152/ajpcell.00145.2015.

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In many cancers, malignant cells can spread from the primary tumor through blood circulation and initiate metastasis in secondary organs. Metastatic colonization may depend not only on inherent properties of cancer cells, but also on suitable microenvironments in distant sites. Increasing evidence suggests that the nature of the microenvironment may determine the fate of disseminated cancer cells, providing either hindrance or support for cancer cell propagation. This can result in strong selective pressure where the vast majority of cancer cells, invading a secondary organ, are either elimina

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Hao, Shuang, Liqun Chen, Wenhui Du, and Huiyan Sun. "A Comprehensive Comparison between Primary Liver Cancer and Liver Metastases through scRNA-Seq Data Analysis." Metabolites 14, no. 2 (2024): 90. http://dx.doi.org/10.3390/metabo14020090.

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Metastasis is one of the leading causes of cancer-related deaths. A comprehensive comparison of the differences between primary and metastatic cancers within the same organ can aid in understanding the growth mechanisms of cancer cells at metastatic sites, thereby helping to develop more effective targeted treatment strategies. Primary liver cancer is one of the most common types of cancer, and the liver is also one of the main metastatic sites. In this paper, we utilize single-cell RNA-Seq data to compare primary liver cancer and colorectal liver metastases from multiple perspectives, includi

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Wan, Xiaochun, and Junxin Li. "DcR3 acts as a tumor marker of metastatic cancers." Journal of Immunology 200, no. 1_Supplement (2018): 178.45. http://dx.doi.org/10.4049/jimmunol.200.supp.178.45.

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Abstract Decoy receptor 3 (DcR3) is a soluble protein that competitively binds Fas ligand and has an anti-apoptotic role. Abnormally elevated DcR3 in malignant tumors may help cancer cells metastasize by suppressing immune responses and establishing metastatic lesions. However, whether DcR3 is valuable in differentiating cancer metastasis from non-metastasis remains largely unclear. In this study, we produced anti-DcR3 monoclonal antibodies and established a sensitive ELISA (11–12000 pg/ml, R2= 0.9941) to measure serum levels of DcR3 in cancer patients. DcR3 was significantly elevated in gastr

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Chen, Chao, Haozhen Liu, Qumiao Xu, Xiuqing Zhang, Feng Mu, and Jixian Liu. "Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types." BioMed Research International 2022 (June 25, 2022): 1–9. http://dx.doi.org/10.1155/2022/9386477.

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Metastasis is one of the characteristics of advanced cancer and the primary cause of cancer-related deaths from cancer, but the mechanism underlying metastasis is unclear, and there is a lack of metastasis markers. PTPRT is a protein-coding gene involved in both signal transduction and cellular adhesion. It is also known as a tumor suppressor gene that inhibits cell malignant proliferation by inhibiting the STAT3 pathway. Recent studies have reported that PTPRT is involved in the early metastatic seeding of colorectal cancer; however, the correlation between PTPRT and metastasis in other types

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Choe, Soohyun, Minyeong Jeon, and Hyunho Yoon. "Advanced Therapeutic Approaches for Metastatic Ovarian Cancer." Cancers 17, no. 5 (2025): 788. https://doi.org/10.3390/cancers17050788.

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Ovarian cancer is the fifth leading cause of cancer-related death among women, which is one of the most common gynecological cancers worldwide. Although several cytoreductive surgeries and chemotherapies have been attempted to address ovarian cancer, the disease still shows poor prognosis and survival rates due to prevalent metastasis. Peritoneal metastasis is recognized as the primary route of metastatic progression in ovarian cancer. It causes severe symptoms in patients, but it is generally difficult to detect at an early stage. Current anti-cancer therapy is insufficient to completely trea

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Li, Wenliang. "Abstract 5571: Identifying and targeting novel kinase regulators for cancer metastasis." Cancer Research 85, no. 8_Supplement_1 (2025): 5571. https://doi.org/10.1158/1538-7445.am2025-5571.

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Abstract Background: Metastasis is responsible for &gt;90% of cancer death. However, metastasis is still poorly understood and the current approaches to prevent or treat human metastatic cancers are largely unsuccessful. Methods and Results: Through RNAi and cDNA functional screening, genomics analysis, and functional validations, we have identified several critical but previously unknown/understudied kinase regulators for metastasis. As an example, shRNA screening revealed that GPCR-kinase 3 (GRK3) is essential preferentially for highly metastatic cancer cells as compared to lowly metasta

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Geng, De-Yi, Qing-Shan Chen, Wan-Xian Chen, et al. "Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer." World Journal of Clinical Oncology 15, no. 4 (2024): 531–39. http://dx.doi.org/10.5306/wjco.v15.i4.531.

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Metastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfunction of splicing factors and abnormal expression of s

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Liu, Heshu, Tao Wen, Ying Zhou, et al. "DCLK1 Plays a Metastatic-Promoting Role in Human Breast Cancer Cells." BioMed Research International 2019 (May 15, 2019): 1–8. http://dx.doi.org/10.1155/2019/1061979.

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Background. Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data regarding the functional role of DCLK1 in breast cancer metastasis. In the present study, we sought to investigate whether and how DCLK1 plays a metastatic-promoting role in human breast cancer cells.Methods. We used Crispr/Cas9 technology to knock out DCLK1 in breast cancer cell line BT474, which basically possesses DCLK1 at a higher level, and stably overexpressed DCLK

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Zarin, Bahare, Laleh Rafiee, Parnaz Daneshpajouhnejad, and Shaghayegh Haghjooy Javanmard. "A review on the role of CAFs and CAF-derived exosomes in progression and metastasis of digestive system cancers." Tumor Biology 43, no. 1 (2021): 141–57. http://dx.doi.org/10.3233/tub-200075.

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Cancers evolve as a result of the accelerated proliferation of cancer cells in a complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are the master regulators of any step of cancer development. The tumor microenvironment is composed of many cellular and noncellular components that contribute to the evolution of cancer cells. Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the TME that implicate in tumor progression and metastasis dissemination through secretion of oncogenic factors which are carried to the secondary metastatic sites thr

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Horiuchi, Atsushi, Keijiro Nozawa, Takuya Akahane, et al. "Skin Metastasis From Sigmoid Colon Cancer." International Surgery 96, no. 2 (2011): 135–38. http://dx.doi.org/10.9738/1391.1.

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Abstract Skin metastases from visceral cancers are rare and the reported incidence from all visceral cancers is 1.4% to 10%. Skin metastases from colorectal cancers account for only 5% of metastatic skin cancers, among which scalp metastases are very rare. We describe a 53-year-old man with scalp metastasis derived from sigmoid colon cancer that was diagnosed and surgically resected in 2005. Metastatic lung tumors that developed thereafter were surgically resected and then chemotherapy was administered. However, metastatic brain tumors occurred in 2008, and these were treated by γ-knife radios

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Liu, Zhentao, Yu-Chiao Chiu, Yidong Chen, and Yufei Huang. "A Metastatic Cancer Expression Generator (MetGen): A Generative Contrastive Learning Framework for Metastatic Cancer Generation." Cancers 16, no. 9 (2024): 1653. http://dx.doi.org/10.3390/cancers16091653.

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Despite significant advances in tumor biology and clinical therapeutics, metastasis remains the primary cause of cancer-related deaths. While RNA-seq technology has been used extensively to study metastatic cancer characteristics, challenges persist in acquiring adequate transcriptomic data. To overcome this challenge, we propose MetGen, a generative contrastive learning tool based on a deep learning model. MetGen generates synthetic metastatic cancer expression profiles using primary cancer and normal tissue expression data. Our results demonstrate that MetGen generates comparable samples to

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Adachi, Y., H. Yamamoto, F. Itoh, Y. Hinoda, Y. Okada, and K. Imai. "Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers." Gut 45, no. 2 (1999): 252–58. http://dx.doi.org/10.1136/gut.45.2.252.

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BACKGROUND/AIMMatrilysin is one of the matrix metalloproteinases that has a critical role in tumour invasion, and is often expressed in gastrointestinal cancers. The aim of this study was to examine the role of matrilysin in metastasis of human colorectal cancers.PATIENTS (SUBJECTS)/METHODSThe relation between matrilysin expression and Dukes’s type was investigated immunohistochemically in 83 surgically resected colorectal cancers, including five with liver metastasis. Moreover, the effects of matrilysin on the in vivo invasive and metastatic potential of colon cancer cells transfected with ma

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19

Park, Misung, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, and Hyunho Yoon. "Breast Cancer Metastasis: Mechanisms and Therapeutic Implications." International Journal of Molecular Sciences 23, no. 12 (2022): 6806. http://dx.doi.org/10.3390/ijms23126806.

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Breast cancer is the most common malignancy in women worldwide. Metastasis is the leading cause of high mortality in most cancers. Although predicting the early stage of breast cancer before metastasis can increase the survival rate, breast cancer is often discovered or diagnosed after metastasis has occurred. In general, breast cancer has a poor prognosis because it starts as a local disease and can spread to lymph nodes or distant organs, contributing to a significant impediment in breast cancer treatment. Metastatic breast cancer cells acquire aggressive characteristics from the tumor micro

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Sharma, Rajesh, Zinal Chheda, Venkatakrishna Jala, and Bodduluri Haribabu. "Interactions within the tumor microenvironment imprint metastatic traits in cancer cells (TUM6P.1001)." Journal of Immunology 194, no. 1_Supplement (2015): 141.25. http://dx.doi.org/10.4049/jimmunol.194.supp.141.25.

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Abstract Metastasis accounts for majority of deaths across cancer types. Tumor microenvironment plays an impotant role in enhancing metastatic propensity of cancer cells. To explore the mechanisms, we herein established a model by in vivo passaging the Lewis lung carcinoma (3LL) cells with 1-2 week of culture in between passages. When injected subcutaneously, 3LL cells have minimal metastasis, while in vivo passaged (p-)3LL cells showed robust metastasis. Sorted p-3LL cells from tumors of the whole body RFP transgenic mice were equally metastatic suggesting that cancer cell intrinsic changes a

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Tarragó-Celada, Josep, and Marta Cascante. "Targeting the Metabolic Adaptation of Metastatic Cancer." Cancers 13, no. 7 (2021): 1641. http://dx.doi.org/10.3390/cancers13071641.

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Metabolic adaptation is emerging as an important hallmark of cancer and metastasis. In the last decade, increasing evidence has shown the importance of metabolic alterations underlying the metastatic process, especially in breast cancer metastasis but also in colorectal cancer metastasis. Being the main cause of cancer-related deaths, it is of great importance to developing new therapeutic strategies that specifically target metastatic cells. In this regard, targeting metabolic pathways of metastatic cells is one of the more promising windows for new therapies of metastatic colorectal cancer,

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Cheng, Liang, David G. Bostwick, Guang Li, Shaobo Zhang, Alexander O. Vortmeyer, and Zhengping Zhuang. "Conserved Genetic Findings in Metastatic Bladder Cancer." Archives of Pathology & Laboratory Medicine 125, no. 9 (2001): 1197–99. http://dx.doi.org/10.5858/2001-125-1197-cgfimb.

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Abstract Context.—Molecular analysis of microsatellite alterations of biologically distinct tumor cell subpopulations from the same patient may aid in the determination of tumor origin and further our understanding of the genetic basis of cancer progression. Design.—The authors examined the pattern of allelic loss with polymorphic microsatellite markers on chromosome 9p21 (D9S161, D9S171, IFNA), regions of putative tumor suppressor gene p16, and on chromosome 17p13 (TP53), the p53 locus, in matched primary and metastatic bladder cancers from 9 patients. All patients underwent cystectomy for bl

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Nakayama, Jun, Yuxuan Han, Yuka Kuroiwa, Kazushi Azuma, Yusuke Yamamoto, and Kentaro Semba. "The In Vivo Selection Method in Breast Cancer Metastasis." International Journal of Molecular Sciences 22, no. 4 (2021): 1886. http://dx.doi.org/10.3390/ijms22041886.

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Metastasis is a complex event in cancer progression and causes most deaths from cancer. Repeated transplantation of metastatic cancer cells derived from transplanted murine organs can be used to select the population of highly metastatic cancer cells; this method is called as in vivo selection. The in vivo selection method and highly metastatic cancer cell lines have contributed to reveal the molecular mechanisms of cancer metastasis. Here, we present an overview of the methodology for the in vivo selection method. Recent comparative analysis of the transplantation methods for metastasis have

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Ali, Sheikh Muhammad Ebad, Badaruddin Sahito, Muhammad Amin Chinoy, Ahmed Nadeem Abbasi, and Adil Khatri. "Cord Compression from Bony Metastasis: An Important Quality of Life Issue which can be Resolved by a Spinal MDT Tumor Board." National Journal of Health Sciences 5, no. 3 (2021): 92–93. http://dx.doi.org/10.21089/njhs.53.0092.

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Cancer prevalence is increasing over the past few decades. Spinal osseous metastasis is one of the most common sites of secondary neoplastic disease among cancer patients [1]. Spinal malignancies can broadly be classified into primary spinal cancers and secondary spinal metastasis. Metastatic spinal cancers are more common than primary malignancy of the spine. Metastatic spinal cancers are further subdivided into two parts based on the involvement of the dura mater; metastasis external to dura mater can be termed as metastatic epidural spinal cancers (MESC); metastasis inside the dura mater is

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Yachida, Shinichi, and Christine A. Iacobuzio-Donahue. "The Pathology and Genetics of Metastatic Pancreatic Cancer." Archives of Pathology & Laboratory Medicine 133, no. 3 (2009): 413–22. http://dx.doi.org/10.5858/133.3.413.

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Abstract Context.—Metastatic disease is the most critical determinant of resectability of pancreatic cancer and accounts for the poor outcome of patients with this disease. Thus, a better understanding of metastatic pancreatic cancer will afford new opportunities for therapeutic intervention. Objective.—To summarize and discuss the current understanding of the clinical and molecular features of metastatic pancreatic cancer. Data Sources.—Published literature on advanced stage pancreatic cancer, pancreatic cancer metastasis, and autopsy findings in patients with pancreatic cancer. Conclusions.—

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Werner-Klein, Melanie. "Abstract IA024: Cellular plasticity during metastatic colony formation in patients." Cancer Research 83, no. 2_Supplement_2 (2023): IA024. http://dx.doi.org/10.1158/1538-7445.metastasis22-ia024.

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Abstract Systemic cancer spread is a process whose complexity is only poorly understood. We have learned over the past years that metastatic dissemination starts very early in the evolution of a malignant clone of most cancers and that disseminated cancer cells (DCC) continue to acquire genomic alterations at the distant site. Consequently, it seems plausible that cellular phenotypes change during metastatic colony formation as well, although the impact of genotype changes on the cellular phenotypes is not clear at all. We studied this process in malignant melanoma, exploiting the unique chanc

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Faltermeier, Claire M., Justin M. Drake, Peter M. Clark, et al. "Functional screen identifies kinases driving prostate cancer visceral and bone metastasis." Proceedings of the National Academy of Sciences 113, no. 2 (2015): E172—E181. http://dx.doi.org/10.1073/pnas.1521674112.

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Mutationally activated kinases play an important role in the progression and metastasis of many cancers. Despite numerous oncogenic alterations implicated in metastatic prostate cancer, mutations of kinases are rare. Several lines of evidence suggest that nonmutated kinases and their pathways are involved in prostate cancer progression, but few kinases have been mechanistically linked to metastasis. Using a mass spectrometry-based phosphoproteomics dataset in concert with gene expression analysis, we selected over 100 kinases potentially implicated in human metastatic prostate cancer for funct

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Trevizani, Maria Eduarda S., Katia K. Oliveira, Fabio A. Marchi, et al. "Abstract 3763: microRNAs associated with metastatic potential in salivary gland mucoepidermoid carcinoma." Cancer Research 83, no. 7_Supplement (2023): 3763. http://dx.doi.org/10.1158/1538-7445.am2023-3763.

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Abstract Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Metastatic spread occurs in up to 80% of high-grade tumors and it is a strong predictor of poor outcome, however, the mechanisms underlying this process are largely unknown. Large-scale microRNA expression profiling studies of human cancers have demonstrated that dysregulation of miRNA is frequently associated with many cancer types. The aim of this study was to investigate the microRNA profile in metastatic versus non-metastatic MECs. Using Real Time RT-PCR (qPCR) we have analyzed the expression

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Singh Randhawa, Amritjot. "Metastatic Breast Cancer to the Uterine Cervix Mimicking Cervical Cancer." Indian Journal of Cancer Education and Research 8, no. 1 (2020): 49–52. http://dx.doi.org/10.21088/ijcer.2321.9815.8120.8.

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Xu, Songjun, Danyang Yu, Shuwei Li, Christopher Moy, and Julio Molineros. "Abstract LB014: The role of genetic alterations in metastatic development insights from a large-scale genomic database." Cancer Research 84, no. 7_Supplement (2024): LB014. http://dx.doi.org/10.1158/1538-7445.am2024-lb014.

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Abstract Metastasis remains a major challenge in cancer treatment, with somatic genetic alterations being a crucial feature in progression. This study harnesses the whole genome sequencing data in the Genomics England biobank (GEL), cataloging of somatic alterations in the context of cancer metastasis. Our research aims to uncover the genetic underpinnings that facilitate the spread of cancer from its primary site to secondary locations by analyzing clinicogenomic data from 3047 cancer patients with metastatic progression. In this study, we analyzed the complex relationship between somatic alt

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Alcantara, Veronica Siton, Sut Mo Zachary Chan, Fuh Yong Wong, John Carson Allen, and Geok Hoon Lim. "Determining the Need for Metastatic Staging in Patients with Bilateral Breast Cancers." Current Oncology 31, no. 4 (2024): 1936–46. http://dx.doi.org/10.3390/curroncol31040145.

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Introduction: Bilateral breast cancers (BBC) diagnosed at an interval apart are uncommon. While metastatic staging guidelines are established in patients with unilateral breast cancer, its role in BBC diagnosed at an interval apart is unclear. We aim to identify the subgroup who would benefit from metastatic staging at contralateral cancer diagnosis. Methods: Eligible patients were divided into three categories: (A) ipsilateral invasive cancer and contralateral ductal carcinoma in situ (DCIS), (B) bilateral invasive cancers and (C) ipsilateral DCIS and contralateral invasive cancer and reviewe

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Erez, Neta. "Abstract IA013: Stromal and immune plasticity shape the metastatic microenvironment." Cancer Research 84, no. 22_Supplement (2024): IA013. http://dx.doi.org/10.1158/1538-7445.tumbody-ia013.

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Abstract Mortality from cancer is almost exclusively due to metastasis to distant organs. Therefore, understanding the biology of tumor metastasis is the most significant challenge in cancer research today. The tumor microenvironment is central in supporting tumor growth. However, the role of the metastatic microenvironment in the multistage process of metastasis is largely unresolved. Since each metastatic microenvironment exerts specific functions that support or oppose colonization by disseminated tumor, understanding distinct organ-specific mechanisms that enable metastatic growth is of cr

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Park, Sun H., Shunsuke Tsuzuki, Kelly F. Contino, et al. "Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression." Life Science Alliance 7, no. 12 (2024): e202302041. http://dx.doi.org/10.26508/lsa.202302041.

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Although the role of peripheral nerves in cancer progression has been appreciated, little is known regarding cancer/sensory nerve crosstalk and its contribution to bone metastasis and associated pain. In this study, we revealed that the cancer/sensory nerve crosstalk plays a crucial role in bone metastatic progression. We found that (i) periosteal sensory nerves expressing calcitonin gene–related peptide (CGRP) are enriched in mice with bone metastasis; (ii) cancer patients with bone metastasis have elevated CGRP serum levels; (iii) bone metastatic patient tumor samples express elevated calcit

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Ganesh, Karuna. "Abstract IA015: Combined single cell atlasing and organoid modeling reveal progressive plasticity during human colorectal cancer metastasis." Cancer Research 82, no. 23_Supplement_1 (2022): IA015. http://dx.doi.org/10.1158/1538-7445.crc22-ia015.

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Abstract Metastatic cancers invariably relapse due to the emergence of therapy resistant subclones that are capable of self-renewal, slow cell-cycling, tumor re-initiation and therapy resistance. However, the molecular mechanisms that underpin the phenotypic plasticity of metastasis stem cells, their relationship to tumor initiating cancer stem cells and macrometastasis, and the co-evolution of the immune response to dynamically emerging tumor regenerative states are not understood. We are adopting a patient-derived functional biospecimen approach combining (1) hypothesis-generation using tran

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Calvo-Alcañiz, Camilo, Padma S. Rajagopal, Sanju Sinha, et al. "Abstract 985: Is the transcriptome of primary and metastatic cancers closer to their origin or target tissues." Cancer Research 82, no. 12_Supplement (2022): 985. http://dx.doi.org/10.1158/1538-7445.am2022-985.

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Abstract Introduction: Most cancer deaths are caused by metastasis, yet understanding how metastatic cancers adapt from their origin tissues to their target tissues remains a fundamental scientific and clinical challenge. To date, no studies have systematically analyzed the transcriptomic similarity of metastatic cancers to their target tissues in a genome wide manner. Here, we ask if the overall gene expression of primary and metastatic tumors is closer to their tissue of origin or closer to their target tissue? Next, we aim to identify the key pathways in metastatic tumors whose gene express

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Yu, Yanlin. "The Function of NK Cells in Tumor Metastasis and NK Cell-Based Immunotherapy." Cancers 15, no. 8 (2023): 2323. http://dx.doi.org/10.3390/cancers15082323.

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Metastatic tumors cause the most deaths in cancer patients. Treating metastasis remains the primary goal of current cancer research. Although the immune system prevents and kills the tumor cells, the function of the immune system in metastatic cancer has been unappreciated for decades because tumors are able to develop complex signaling pathways to suppress immune responses, leading them to escape detection and elimination. Studies showed NK cell-based therapies have many advantages and promise for fighting metastatic cancers. We here review the function of the immune system in tumor progressi

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Polynovskiy, A., D. Kuz'michev, Z. Mamedli, et al. "Successful Case of Treatment the Patient with Synchronous Rectal and Sigmoid Cancers and Synchronous Lung Metastasis." Medical Radiology and radiation safety 66, no. 3 (2021): 76–81. http://dx.doi.org/10.12737/1024-6177-2021-66-3-76-81.

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Colorectal cancers (CRC) takes the leading position in the incidence of morbidity and mortality worldwide. Metastatic CRC in the primary diagnosis ranges from 15 to 35 %. Lung metastasis are the most frequent extraperitoneal manifestation of the metastatic process. Such patients are relatively rare and there are no clear recommendations for their treatment tactics to date. This clinical case describes a successful strategy of using preoperative prolonged chemoradiotherapy on a primary tumor and stereotactic irradiation of lung metastasis, with courses of chemotherapy, with further radical lapa

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Jones, Angelle D., Carissa Lester, and Susan E. Waltz. "Abstract 1243: RON receptor signaling enhances prostate cancer metastasis in Hi-Myc mice." Cancer Research 83, no. 7_Supplement (2023): 1243. http://dx.doi.org/10.1158/1538-7445.am2023-1243.

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Abstract Prostate cancer (PCa) is the second leading cause of cancer mortality among men globally. Death from PCa is typically due to the lack of effective treatments for advanced forms of prostate cancers including castration-resistant prostate cancer (CRPC) and metastatic prostate cancers (mPCa). Distantly metastasized cancers drop the 5-year survival rate from 98% to 30%. Understanding the intrinsic and extrinsic mechanisms that lead to the development of these advanced prostate cancers could improve treatment options. The RON receptor tyrosine kinase is a cell surface receptor, which is ac

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Nizam, Amanda, Donald L. Trump, and Jeanny B. Aragon-Ching. "Molecular characterization of brain metastases in patients with metastatic urothelial cancer." Journal of Clinical Oncology 36, no. 6_suppl (2018): 509. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.509.

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509 Background: Urothelial cancers are the 6th most common cause of all new cancer cases in 2017. Metastatic disease to the brain is rare but has a poor prognosis. There is little information regarding the phenotypic and molecular characteristics of urothelial cancers involving the brain. We sought to evaluate the clinical and tumor molecular characteristics in patients with metastatic urothelial cancer to the brain. Methods: In a single institution retrospective chart review, 48 patients were found to have metastatic bladder cancer from 2006 to 2015, 4 had brain metastases. The demographics,

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Kumar, Arvind, and Indranil Ghosh. "Prospective Study of Metastatic Lung Cancer Patients." International Journal of Science and Research (IJSR) 10, no. 1 (2021): 1469–70. https://doi.org/10.21275/sr201215092701.

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Jackson, Abigail E., and Keren I. Hilgendorf. "Abstract B031: Lean adipocyte-derived lipid decreases metastatic potential of breast cancer cells." Cancer Research 84, no. 22_Supplement (2024): B031. http://dx.doi.org/10.1158/1538-7445.tumbody-b031.

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Abstract Obesity rates are increasing globally, making it of critical importance to study obesity-linked diseases. Breast cancer is the most common cancer in women, and obesity is associated with both increased incidence and metastatic progression of breast cancer. Metastasis formation depends on a cancer cell leaving the primary site, migrating through the bloodstream, and establishing new growth in a distant site. Both metastasizing cell-intrinsic and metastatic site-dependent factors can help to regulate the effectiveness of this process; however, it is unknown whether obesity-linked metast

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Ahrenfeldt, Johanne, Ditte S. Christensen, Mateo Sokač, Judit Kisistók, Nicholas McGranahan, and Nicolai J. Birkbak. "Computational Analysis Reveals the Temporal Acquisition of Pathway Alterations during the Evolution of Cancer." Cancers 14, no. 23 (2022): 5817. http://dx.doi.org/10.3390/cancers14235817.

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Cancer metastasis is the lethal developmental step in cancer, responsible for the majority of cancer deaths. To metastasise, cancer cells must acquire the ability to disseminate systemically and to escape an activated immune response. Here, we endeavoured to investigate if metastatic dissemination reflects acquisition of genomic traits that are selected for. We acquired mutation and copy number data from 8332 tumours representing 19 cancer types acquired from The Cancer Genome Atlas and the Hartwig Medical Foundation. A total of 827,344 non-synonymous mutations across 8332 tumour samples repre

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McElduff, Sarina, Daniel Bronder, Mercedes Duran, and Samuel Bakhoum. "Abstract 2755: Characterizing breast cancer cells following immune pruning in mice." Cancer Research 84, no. 6_Supplement (2024): 2755. http://dx.doi.org/10.1158/1538-7445.am2024-2755.

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Abstract In cancer patients, metastasis is the leading cause of death. Indeed, primary tumors which are diagnosed early and treated in a timely manner have the highest rate of success. In contrast, metastatic disease and late diagnosis of tumors portend poor outcomes. Thus, understanding the underlying biology and developing novel therapeutic approaches for metastatic cancers is pivotal. Most cancer-based mutational characteristics are tissue-dependent, and cancers with higher mutational load are generally more susceptible to immunotherapy. We observed that poorly metastatic, murine breast can

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Feng, Yinghua, Xiuli Zhang, Guangpeng Wang, et al. "Comprehensive Integrated Analysis Reveals the Spatiotemporal Microevolution of Cancer Cells in Patients with Bone-Metastatic Prostate Cancer." Biomedicines 13, no. 4 (2025): 909. https://doi.org/10.3390/biomedicines13040909.

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Background/Objectives: Bone metastasis is a frequent and life-threatening event in advanced cancers, affecting up to 70–85% of prostate cancer patients. Understanding the cellular and molecular mechanisms underlying bone metastasis is essential for developing targeted therapies. This study aimed to systematically characterize the heterogeneity and microenvironmental adaptation of prostate cancer bone metastases using single-cell transcriptomics. Methods: We integrated the largest single-cell transcriptome dataset to date, encompassing 124 samples from primary prostate tumors, various bone meta

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Bozkurt, Kemal Kürşat, Safiye Aktaş, and Merih Güray Durak. "Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer." Archives of Current Medical Research 5, no. 2 (2024): 50–55. http://dx.doi.org/10.47482/acmr.1468113.

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Breast cancer is the most common type of female cancer in Turkey, and metastasis is the most important cause of death, as in other solid organ cancers. Triple-negative tumors constitute 15-20% of breast cancer patients. Within three years after the development of the primary tumor, the tumor spreads to other organs. Breast cancer tends to spread to distant organs, such as bone, liver, brain, lung, and adrenal gland, either through regional lymph nodes or vascular channels. This condition, defined as the tendency to metastasize to specific organs, is called organotropism. Triple-negative breast

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Lin, Yu-Chun, and Dong-Qing Chin. "Suppressions of metastatic breast cancer invasion and metastasis to brain/cross talk HER2/ERK1/2/MMP-9 signaling pathway." American Journal of BioMedicine 4, no. 2 (2016): 227–39. http://dx.doi.org/10.18081/2333-5106/016-227-239.

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Understanding the molecular pathways that contribute to the development of metastatic breast cancer invasion and metastasis to brain is needed to improve the clinical utility of novel agents, and to predict the success of targeted personalized therapy based on tumor-specific mutations. Little is known about the clinical significance of HER2/ERK1/2/MMP-9 signaling pathway in breast cancer. We performed Global exon array to study the expression of ERK1/2/MMP-9 signaling pathway in metastatic breast cancer to brain, compared its expression in primary breast cancer and breast cancers metastatic to

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Lin, Yu-Chun, and Dong-Qing Chin. "Suppressions of metastatic breast cancer invasion and metastasis to brain/cross talk HER2/ERK1/2/MMP-9 signaling pathway." American Journal of BioMedicine 6, no. 4 (2018): 349–61. http://dx.doi.org/10.18081/2333-5106/018-349-361.

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Understanding the molecular pathways that contribute to the development of metastatic breast cancer invasion and metastasis to brain is needed to improve the clinical utility of novel agents, and to predict the success of targeted personalized therapy based on tumor-specific mutations. Little is known about the clinical significance of HER2/ERK1/2/MMP-9 signaling pathway in breast cancer. We performed Global exon array to study the expression of ERK1/2/MMP-9 signaling pathway in metastatic breast cancer to brain, compared its expression in primary breast cancer and breast cancers metastatic to

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Gerbec, Zachary J., Antonio Serapio-Palacios, Sarah E. Woodword, Jorge Pena Diaz, Brett Finlay, and Shoukat Dedhar. "Abstract A047: Tumor-derived bacteria drive breast cancer metastasis." Cancer Research 83, no. 2_Supplement_2 (2023): A047. http://dx.doi.org/10.1158/1538-7445.metastasis22-a047.

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Abstract Metastasis is a major barrier to long-term survival and therapeutic options for aggressive, metastatic forms of breast cancer remain limited. Studies using patient samples have identified tumor-resident bacteria that preferentially associate with specific breast cancer types including highly aggressive TNBC. However, it is not yet understood how intratumoral bacteria directly contributes to disease progression and metastatic propensity independent of other prognostic factors. It is therefore the goal of the Dedhar and Finlay labs to identify how specific bacteria within metastatic bre

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Al Armashi, Abdul Rahman, Jorge A. Garcia, and Jason R. Brown. "Racial disparities in GU cancer metastasis: A comprehensive analysis from 2010-2018." Journal of Clinical Oncology 42, no. 4_suppl (2024): 30. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.30.

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30 Background: Patterns of metastatic spread vary between bladder, kidney, and prostate metastasis. Of these cancers, kidney cancer often spreads to the brain, while prostate cancer is most likely to spread to bone, for example. Sites of metastasis can influence prognosis and in some instances may even direct therapy. The knowledge gap on racial disparities in metastatic patterns merits further investigation. Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified bladder, kidney, and prostate cancer patients (2010-2018) in White (W) and Black (B) races. D

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Winkler, Juliane, Weilun Tan, Angela O. Pisco, Andrei Goga, Spyros Darmanis, and Zena Werb. "Abstract 964: Tumor cell plasticity promotes metastasis across heterogeneous tumors." Cancer Research 82, no. 12_Supplement (2022): 964. http://dx.doi.org/10.1158/1538-7445.am2022-964.

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Abstract Metastasis, the growth of secondary tumors in distant organs, is the major cause of cancer-related deaths due to insufficient therapeutic effects of conventional treatment. Individual tumor cells exhibit heterogeneous features and growth potentials within the same tumor that may influence metastasis formation. During the metastatic cascade, tumor cells adapt their phenotype to various microenvironments that are distinct from their original site resulting in heterogeneous metastatic cells that often are resistant to conventional treatment. The underlying mechanisms of why some tumor ce

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