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1

A, Stein Cy, and National Cancer Institute (U.S.). Office of Cancer Communications, eds. Suramin, an active agent in metastatic adrenocortical carcinoma. National Cancer Institute, Office of Cancer Communications, 1988.

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2

Warner, Ellen. Phase I - II study of vinblastine and oral cyclosporin a in metastatic renal cell carcinoma. National Library of Canada, 1996.

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3

1952-, Wick Mark R., ed. Metastatic carcinomas of unknown origin. DEMOS, 2008.

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4

International, Symposium on Cellular Oncology (2nd 1985 Palm Springs Calif ). Occult nodal metastasis in solid carcinomata. Praeger, 1987.

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5

Hoogewoud, H. M. Hepatocellular carcinoma and liver metastases: Diagnosis and treatment. Springer-Verlag, 1993.

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6

C, Bollack, Jacqmin D, and European Organization for Research on Treatment of Cancer. Genito-Urinary Tract Cancer Cooperative Group., eds. Basic research and treatment of renal cell carcinoma metastasis: Proceedings of an EORTC Genitourinary Group meeting, held in Strasbourg, France, November 4, 1988. Wiley-Liss, 1990.

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7

N, Chatzigeorgiou Konstantinos, and Bontis John N, eds. Peritoneal carcinomatosis from ovarian cancer. Nova Science Publishers, 2005.

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8

McElligott, Anthony M. The role of matrix metalloproteinases and their inhibitors, the tissue inhibitors of metalloproteinases, in renal cell carcinoma cell invasion and metastasis. The Author], 1999.

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9

Surgical Treatment of Metastatic Renal Cell Carcinoma. Derman Tıbbi Yayıncılık, 2015. http://dx.doi.org/10.4328/derman.9786055121242.

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10

Huang, William C., and Ezequiel Becher. Advanced and Metastatic Renal Cell Carcinoma an Issue of Urologic Clinics. Elsevier, 2020.

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11

Calabrò, Fabio, and Cora N. Sternberg. Treatment of metastatic bladder cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0079.

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Although bladder cancer is considered a chemosensitive malignancy, the prognosis of patients with metastatic disease is poor, with a median survival of approximately 12–14 months in good prognosis patients and with cure in only a minority. The addition of new drugs to the standard cisplatin-based regimens has not improved these outcomes. In this chapter, we highlight the role of chemotherapy and the impact of the new targeted agents in the treatment of metastatic bladder carcinoma. A better understanding of the underlying biology and the molecular patterns of urothelial bladder cancer has led
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12

Massey, Veta Hamblen. RELATIONSHIP BETWEEN POWERLESSNESS, HARDINESS, DIAGNOSIS, AND HOPELESSNESS IN PERSONS HOSPITALIZED FOR CHOLECYSTECTOMY OR METASTATIC CARCINOMA. 1989.

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13

Mano, Roy, and Ofer Yossepowitch. Adenocarcinoma of the bladder. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0081.

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Adenocarcinoma of the bladder accounts for 0.5–2 of bladder tumours. Risk factors include bladder exstrophy, bladder augmentation, schistosomiasis, and endometriosis. Bladder adenocarcinoma is classified as primary, arising from the bladder or urachal remnant, and secondary (metastatic). Most patients present with haematuria and irritative voiding symptoms. On imaging, a typical lesion is commonly located at the bladder dome. Compared to urothelial carcinoma (UC), most adenocarcinomas are diagnosed at high grade and advanced stage. Surgical treatment of localized disease entails partial cystec
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14

Wick, Mark. Metastatic Carcinomas of Unknown Origin. Springer Publishing Company, Incorporated, 2009.

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15

Wick, Mark R. Metastatic Carcinomas of Unknown Origin. Springer Publishing Company, Incorporated, 2008.

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16

Keshav, Satish, and Palak Trivedi. Liver cancer. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0218.

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Primary hepatocellular carcinoma (HCC) arises from hepatocytes and is one of the commonest solid-organ malignancies in the world, particularly in the Far East and in sub-Saharan Africa. Cholangiocarcinoma arises from the biliary epithelium. The incidence is rising in the West, and primary sclerosing cholangitis (PSC) is an important risk factor (15% lifetime risk). Other forms of liver cancer include metastatic cancer, which is much more common in the West than any primary liver cancer, accounting for 90% of liver cancers and for which common primary sites are the colon, the stomach, the breas
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17

Hoskin, Peter. Vulva and vagina. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199696567.003.0014.

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Chapter 9b discusses carcinoma of the vulva, which is primarily a surgical disease best treated by wide surgical resection, radical vulvectomy, and inguinal lymph node dissection based on presenting stage. Rarely, locally advanced primary disease may be presented for primary radiotherapy treatment. Postoperative radiotherapy is recommended for tumours invading >7 mm in a vertical direction. The first station regional lymph nodes in the inguinal region are best treated by radical surgical dissection, but fixed inoperable lymph nodes may benefit from primary radiotherapy which may be followed
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18

Hoogewoud, Henri-Marcel, and A. Rohner. Hepatocellular Carcinoma and Liver Metastases: Diagnosis and Treatment. Springer, 2012.

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19

Hoogewoud, Henri-Marcel, and A. Rohner. Hepatocellular Carcinoma and Liver Metastases: Diagnosis and Treatment. Springer London, Limited, 2012.

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20

Eisen, Tim. The patient with renal cell cancer. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0172.

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Renal cancer is the commonest malignancy of the kidney and worldwide, accounts for between 2% and 3% of the total cancer burden. The mainstay of curative treatment remains surgery. There have been significant advances in surgical technique, the most important ones being nephron-sparing surgery and laparoscopic nephrectomy. The medical treatment of advanced renal cell cancer has only improved markedly in the last decade with the development of antiangiogenic tyrosine-kinase inhibitors, inhibitors of mammalian target of rapamycin, and a diminished role for immunotherapy.Tyrosine-kinase inhibitor
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21

Staehler, Gerd, and Sigmund Pomer. Contemporary Research on Renal Cell Carcinoma: Basic and Clinical Developments. Springer London, Limited, 2012.

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22

Staehler, Gerd, and Luc P. Balant. Contemporary Research on Renal Cell Carcinoma: Basic and Clinical Developments. Springer, 2011.

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23

Matin, Rubeta, Jane McGregor, and Catherine Harwood. Skin cancer. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0259.

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Skin cancer is very common in the UK, and its incidence is rising rapidly. There are two broad classes of primary skin cancer: non-melanoma and melanoma. Non-melanoma skin cancer is the commonest form (100 000 cases diagnosed annually in the UK), accounting for nine out of ten skin cancers and includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Cutaneous melanoma is less common (10 000 cases diagnosed in the UK annually) but confers a significantly worse prognosis and accounts for 75% of skin cancer related deaths. There are also a number of other, rarer, non-melanoma skin c
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24

Myers, Jeffrey. Oral Cancer Metastasis. Springer, 2014.

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25

(Editor), C. G. Bollack, and D. Jacqmin (Editor), eds. Basic Research and Treatment of Renal Cell Carcinoma Metastasis: Proceedings of an Eortc Genitourinary Group Meeting, Held in Strasbourg, France, Nove (Renal Cell Carcinoma Metastasis). Wiley-Liss, 1990.

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26

(Editor), Moloy, and Ph.D Garth Nicolson (Editor), eds. Occult Nodal Metastasis in Solid Carcinomata: Second International Symposium on Cellular Oncology (Cancer Research Monographs). Praeger Publishers, 1987.

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27

Prati, Raquel, and Olga Olevsky. Breast Cancer Staging and Treatment. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0012.

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Breast carcinomas are a heterogeneous group of diseases that can be further characterized based on their histology, biomarkers, and molecular profiles. These characteristics, gathered during disease staging, provide crucial information with regard to treatment decisions. Staging has evolved from informing the operability of breast tumors to providing prognostic information, and consequently helping establish local and systemic treatment guidelines. This chapter provides a succinct overview of breast cancer staging and treatment. Topics covered include the histological classification of breast
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28

Prasad, Raj K., and Imeshi Wijetunga. Hepatobiliary surgery (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198749813.003.0002.

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This chapter discusses common elective and emergency presentations to hepatobiliary surgery. Gallstone disease, being the commonest hepatobiliary condition encountered by general surgical trainees, is discussed in detail. A separate section on acute ascending cholangitis is included with a brief description of the steps involved in laparoscopic cholecystectomy. Acute pancreatitis is discussed in Pancreatic Surgery Chapter 3. An overview of the assessment and management of post-cholecystectomy complications, such as bile duct injury and vascular injuries, is provided with illustrations. Managem
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