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Journal articles on the topic 'Metastatic Head'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mandell-Brown, Mark, Jonas T. Johnson, Bruce S. Rabin, Ellen Hamill, and Robin L. Wagner. "Neck Node Immunoreactivity in Head and Neck Carcinoma." Otolaryngology–Head and Neck Surgery 95, no. 4 (1986): 500–506. http://dx.doi.org/10.1177/019459988609500414.

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T-lymphocyte subpopulations were quantitated in lymph nodes that contained metastatic tumor—or no metastasis—from patients who had squamous cell carcinoma of the upper aerodigestive tract. In addition, the lymphocyte subpopulations in peripheral blood were quantitated. The content of prostaglandin E2 within each node that was evaluated was also determined. Lymph nodes containing metastatic tumor had significantly higher helper/suppressor ratio than lymph nodes that were not involved. Quantification of the T-lymphocyte subpopulations in peripheral blood did not indicate the presence of metastat

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2

Barham, William T., Marshall Patrick Stagg, Rula Mualla, Michael DiLeo, and Sagar Kansara. "Recurrent and Metastatic Head and Neck Cancer: Mechanisms of Treatment Failure, Treatment Paradigms, and New Horizons." Cancers 17, no. 1 (2025): 144. https://doi.org/10.3390/cancers17010144.

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Background: Head and neck cancer is a deadly disease with over 500,000 cases annually worldwide. Metastatic head and neck cancer accounts for a large proportion of the mortality associated with this disease. Many advances have been made in our understanding of the mechanisms of metastasis. The application of immunotherapy to locally recurrent or metastatic head and neck cancer has not only improved oncologic outcomes but has also provided valuable insights into the mechanisms of immune evasion and ultimately treatment failure. Objectives: This review paper will review our current understanding

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3

Nielsen, Signe B., and Christer Z. Swan. "Renal cell carcinoma metastasis to the vocal cord: A case report." Case Studies in Surgery 3, no. 4 (2017): 11. http://dx.doi.org/10.5430/css.v3n4p11.

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Background: Approximately 15% of renal cell carcinoma (RCC) cases develop extracranial head and neck metastases. Metastatic lesions to the larynx from outside the head and neck region are rare.Methods: We report an unusual case of RCC metastatic to the left vocal cord, in a 57-year-old female. The patient suffered from metastatic RCC, detected 11 months prior to onset of hoarseness, which was her only symptom of glottic metastasis. The tumor was radically excised applying direct laryngoscopy.Results: Histopathologic examination revealed metastasis of RCC clear cell type.Conclusions: Glottic me

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4

Nunez, D. A., C. G. C. Sutherland, and R. K. Sood. "Breast metastasis from a pharyngeal carcinoma." Journal of Laryngology & Otology 103, no. 2 (1989): 227–28. http://dx.doi.org/10.1017/s0022215100108540.

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AbstractThe reported incidence of metastatic disease in head and neck cancer is increasing. The most common site of metastatic involvement in squamous carcinoma of the head and neck is the lung followed by liver, mediastinal nodes and bone. The breast is rarely infiltrated by metastatic disease, 2 per cent or less of clinically detected breast lumps being of nonmammary origin, most frequently malignant melanoma, lymphoma/leukaemia and primary lung carcinoma.A 73-year-old female presented with a primary posterior pharyngeal wall squamous carcinoma and bilateral enlarged neck nodes. She develope

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ÇEÇEN, Ayşe, Esra KAVAZ, and Seda GÜN. "The clinical and prognostic value of the neutrophil lymphocyte ratio, the platelet lymphocyte ratio and mean platelet volume in tinnitus patients." Journal of Experimental and Clinical Medicine 38, no. 3 (2021): 251–54. http://dx.doi.org/10.52142/omujecm.38.3.8.

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Approximately 15% of renal cell carcinomas metastasize to the head and neck region. Here in, we report a rare case report of a patient who underwent nephrectomy for renal cell carcinoma (RCC) ten years ago and presented with metastatic renal cell carcinoma on her lower lip. A 65-year-old woman presented with a rapidly growing mass on the lower lip. Pathology report resulted in renal cell carcinoma metastasis. Although metastatic renal cell carcinoma to the head and neck is uncommon, metastasis should be considered in the differential diagnosis of a rapidly growing vascular lesion in the head a

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ÇEÇEN, Ayşe, Esra KAVAZ, and Seda GÜN. "A rare case: Renal cell carcinoma metastasis to lower lip." Journal of Experimental and Clinical Medicine 38, no. 3 (2021): 396–97. http://dx.doi.org/10.52142/omujecm.38.3.38.

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Approximately 15% of renal cell carcinomas metastasize to the head and neck region. Here in, we report a rare case report of a patient who underwent nephrectomy for renal cell carcinoma (RCC) ten years ago and presented with metastatic renal cell carcinoma on her lower lip. A 65-year-old woman presented with a rapidly growing mass on the lower lip. Pathology report resulted in renal cell carcinoma metastasis. Although metastatic renal cell carcinoma to the head and neck is uncommon, metastasis should be considered in the differential diagnosis of a rapidly growing vascular lesion in the head a

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7

Shabani, Sepehr, Nicholas Pritchard, Tapan A. Padhya, and Matthew Mifsud. "Head and neck cutaneous metastasis of testicular choriocarcinoma." BMJ Case Reports 13, no. 2 (2020): e233337. http://dx.doi.org/10.1136/bcr-2019-233337.

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Testicular choriocarcinoma (CC) is a malignant germ cell tumour which most frequently presents with disseminated metastasis, often involving the lungs, brain and liver. Metastatic are characterised by extensive vascularity, often causing patients to present emergently with potentially life-threatening haemorrhagic complications. We report a patient with disseminated testicular CC, presenting with haemorrhage from a dermal metastatic focus involving the lower lip and mentum, requiring surgical intervention. This unique case illustrates the potential utility of palliative surgery, for the manage

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8

Yucel, Emre A., Tayfun Demirel, Misten Demiryont, Unal Egeli, and Kemal Deger. "An unusual metastatic site of laryngeal carcinoma: scapular muscles." Journal of Laryngology & Otology 117, no. 1 (2003): 85–87. http://dx.doi.org/10.1258/002221503321046757.

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It is well known that in advanced cervical metastatic disease of head and neck squamous cell carcinoma, the incidence of distant metastasis is high. A case of distant metastasis to the scapular muscles from an uncontrolled cervical metastasis of laryngeal carcinoma is presented. Other unusual metastatic sites are reviewed and the possible mechanism of the spread is discussed.

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9

Nakamura, Hiromu, Tetsuya Ogawa, Shunpei Yamanaka, et al. "Immune Status of Cervical Lymph Nodes in Head and Neck Cancer—A Surgical Oncology Perspective." Journal of Personalized Medicine 13, no. 7 (2023): 1174. http://dx.doi.org/10.3390/jpm13071174.

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Neck dissection for cervical lymph node metastasis is an established procedure for head and neck cancer (HNC). However, with the advent of immunotherapy, head and neck surgical oncologists need to rethink removing all lymph nodes, including those with immune function. We investigated the anti-cancer immune response of the cervical lymph nodes in four patients with human papillomavirus type 16 (HPV16)-positive head and neck squamous cell carcinoma. Using lymphocytes extracted from local, metastatic, and non-metastatic lymph nodes and peripheral blood from these patients, we performed an intrace

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10

Saab, Ghaleb A., Fadi W. Abdul-Karim, and Milhem Samara. "Breast carcinoma metastatic to the nasopharynx." Journal of Laryngology & Otology 101, no. 7 (1987): 723–25. http://dx.doi.org/10.1017/s0022215100102609.

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A case report of a patient with adenocarcinoma of the breast with matastasis to the nasopharynx is described. The patient presented initially with pulmonary metastasis followed later by metastasis to the left jugulo-digastric lymph nodes. A prominent but asymptomatic nasopharyngeal mass was concomitantly discovered on head and neck examination. Three months later, symptoms of panhypopituitarism developed. Invasion of the base of the skull and pituitary were documented. Patients with adenocarcinoma of the breast and high cervical node metastasis should have a thorough otolaryngologic and head a

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11

Park, Bae, Choi, et al. "Texture Analysis of Multi-Shot Echo-planar Diffusion-Weighted Imaging in Head and Neck Squamous Cell Carcinoma: The Diagnostic Value for Nodal Metastasis." Journal of Clinical Medicine 8, no. 11 (2019): 1767. http://dx.doi.org/10.3390/jcm8111767.

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Accurate assessment of nodal metastasis in head and neck squamous cell carcinoma (SCC) is important, and diffusion-weighted imaging (DWI) has emerged as a potential technique in differentiating benign from malignant lymph nodes (LNs). This study aims to evaluate the diagnostic performance of texture analysis using apparent diffusion coefficient (ADC) data of multi-shot echo-planar imaging-based DWI (msEPI-DWI) in predicting metastatic LNs of head and neck SCC. 36 patients with pathologically proven head and neck SCC were included in this study. A total of 204 MRI-detected LNs, including 176 su

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12

Lyon, Priscilla R. P., Sean Trevathan, Rudranath Talukdar, Dominic D. Nguyen, Christopher M. McPhaul, and Debby Rampisela. "A Rare Case of Metastatic Hepatocellular Carcinoma to the Hard Palate." Journal of Investigative Medicine High Impact Case Reports 10 (January 2022): 232470962211339. http://dx.doi.org/10.1177/23247096221133989.

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Extrahepatic metastasis of hepatocellular carcinoma (HCC) to the head and neck is unusual, especially the oral cavity/maxillofacial region. Metastatic HCC to the hard palate, however, is particularly rare. The most common site of HCC metastasis is the lung, followed by lymph nodes, bone, and adrenal gland. Importantly, oral cavity metastatic HCC may be misdiagnosed as a primary malignancy, such as a salivary gland carcinoma. In this article, we describe a young woman with metastatic HCC to the hard palate that was initially diagnosed as an acinic cell carcinoma.

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13

Adioui, Tarik, Ahlame Benhamdane, Sanaa Berrag, and Mouna Tamzaourte. "Case of a Sister Mary Joseph’s Nodule in Pancreatic Adenocarcinoma: A Diagnostic Challenge." Scholars Journal of Medical Case Reports 10, no. 12 (2022): 1206–8. http://dx.doi.org/10.36347/sjmcr.2022.v10i12.015.

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Background: Sister Mary Joseph (SMJ) nodule is a rare metastatic umbilical nodule with primary tumor genital or gastrointestinal sites. Pancreas is rare primary location for umbilical metastases. Pancreatic adenocarcinoma associated with SMJN usually arises from the body and tail of the pancreas. We report a case of SMJ nodule’s as a cutaneous manifestation of metastatic pancreatic head cancer. Case Report: A 59-year-old man, presented with epigastric, back pain and weight loss. On examination, an umbilical nodule was noted. Investigations confirmed a nodule of Sister Mary Joseph as a pancreat

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14

Khurayzi, Tawfiq, and Abdullah Alshahrani. "Metastatic paranasal sinuses adenocarcinoma from breast carcinoma, a rare event: a case report." International Journal of Otorhinolaryngology and Head and Neck Surgery 3, no. 4 (2017): 1099. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20174340.

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<p>Metastases to the nose and paranasal sinuses usually respond poorly to treatment and have a poor prognosis. We present a 31 year old lady with rare metastatic paranasal sinuses lesion which is adenocarcinoma that metastasis from breast carcinoma. All of clinical presentation, radiological findings, histopathological and immunohistochemically markers examination reveal metastatic adenocarcinoma. This study presents rare metastasis in head and neck cancer especially from breast to paranasal sinuses.</p>

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15

Hossain, Mohammad Kamal, AKM Asaduzzaman, Md Tauhidul Islam, Ahsanuzzaman Khan, Muhammad Ali Azad, and Mohammad Delwar Hossain. "Nodal Metastasis in Neck: A Clinical Study of 60 Cases." Journal of Armed Forces Medical College, Bangladesh 12, no. 2 (2016): 56–59. http://dx.doi.org/10.3329/jafmc.v12i2.41089.

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Introduction: An enlarged neck node is frequently the first clinical manifestation of a neoplastic process in the head and neck region. The earlier the diagnosis is made, the greater the chance of improved survival. A common denominator to all head-neck malignancy is their ability to metastasize. Although metastasis is not a random event, some tumours have the propensity to extensive local invasion without metastasis whereas others metastasize early in their development. Objective: To evaluate the different primary sites metastasizing to cervical lymph nodes. Materials and Methods:

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16

Onak Kandemir, Nilufer, Figen Barut, Kıvanç Yılmaz, Husnu Tokgoz, Mubin Hosnuter, and Sukru Oguz Ozdamar. "Renal Cell Carcinoma Presenting with Cutaneous Metastasis: A Case Report." Case Reports in Medicine 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/913734.

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Renal cell carcinoma is the most common kidney tumor in adults. Cutaneous metastasis is a rare first symptom of the disease. This paper describes the diagnosis of a renal cell carcinoma that was indicated by cutaneous metastasis in the head and neck region, and considers the etiopathogenesis of such cases. A careful skin examination is important to detect cutaneous metastasis associated with renal cell carcinomas. Metastatic skin lesions in the head and neck region must be taken into consideration during a differential diagnosis.

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17

Adioui, Tarik, Ahlame Benhamdane, Sanaa Berrag, and Mouna Tamzaourte. "Case of a Sister Mary Joseph’s Nodule in Pancreatic Adenocarcinoma: a Diagnostic challenge." Journal of Medical Research and Surgery 3, no. 6 (2022): 123–24. http://dx.doi.org/10.52916/jmrs224094.

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Background: Sister Mary Joseph Nodule (SMJN) is a rare metastatic umbilical nodule with primary tumor genital or gastrointestinal sites. Pancreas is rare primary location for umbilical metastases. Pancreatic adenocarcinoma associated with SMJN usually arise from the body and tail of the pancreas. We report a case of SMJ nodule’s as a cutaneous manifestation of metastatic pancreatic head cancer. Case Report: A 59-year-old man, presented with epigastric, back pain and weight loss. On examination, an umbilical nodule was noted. Investigations confirmed a nodule of sister Mary Joseph as a pancreat

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18

Ryo, E., T. Sato, S. Takeshita, T. Ayabe, and F. Tanaka. "Uterine metastasis from hepatocellular carcinoma: a case report." International Journal of Gynecologic Cancer 16, no. 5 (2006): 1894–96. http://dx.doi.org/10.1136/ijgc-00009577-200609000-00026.

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The extrahepatic spread of hepatocellular carcinoma (HCC) is uncommon. Moreover, metastatic uterine tumor from extragenital primaries is rare. We report a 63-year-old woman with uterine metastasis from HCC. She had undergone transcatheter arterial embolization four times and surgery for HCC from 2–4 years before. This time, she underwent resection of a newborn, head-sized uterine tumor that was proven to be metastasis from HCC. This is the first described case of metastatic uterine tumor originated from HCC.

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19

Srinivasan, B., M. Patel, M. Ethunandan, and V. Ilankovan. "Addison’s disease as a presentation of metastatic malignant melanoma." Annals of The Royal College of Surgeons of England 98, no. 1 (2016): e11-e12. http://dx.doi.org/10.1308/rcsann.2016.0035.

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Melanoma accounts for 5% of all skin cancers. The risk of metastasis is related to the thickness of the tumour, and can affect local, regional and distant sites. Adrenal metastasis from melanoma of the head and neck is uncommon and often asymptomatic. Addison’s disease as a presentation of metastatic melanoma is extremely rare and we are unaware of previous reports in the world literature. We report a case of a patient with metastatic melanoma presenting with signs and symptoms of Addison’s disease.

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20

Uddin, Md Momin, Samia Quadir, Sabiha Quadir, Kazi Shameemus Salam, Debabrota Roy, and Belayat Hossain Siddiquee. "Prevalence of Metastatic Neck Nodes." Bangladesh Journal of Otorhinolaryngology 25, no. 2 (2020): 102–7. http://dx.doi.org/10.3329/bjo.v25i2.45207.

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Background: Head and neck cancers include cancers of the lips, mouth, nasal cavity, paranasal sinuses, pharynx and larynx. Most of these cancers are squamous cell carcinomas (SCCs). The presence of metastatic cervical lymphadenopathy is of particular importance as with every single nodal metastasis, survival of the patient is reduced by one half. Objective: To see the prevalence of metastatic neck node. Methods: The prospective cross-sectional clinical study was carried out in the Department of ENT and Head Neck Surgery, Combined Military Hospital, Dhaka during March’2018 to March,

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21

Sarvanan, K., J. Rajiv Bapuraj, Suresh C. Sharma, B. D. Radotra, N. Khandelwal, and S. Suri. "Computed tomography and ultrasonographic evaluation of metastatic cervical lymph nodes with surgicoclinicopathologic correlation." Journal of Laryngology & Otology 116, no. 3 (2002): 194–99. http://dx.doi.org/10.1258/0022215021910519.

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The detection of cervical lymph nodal metastasis and carotid artery invasion by metastatic lymph nodes is an important issue in the management of head and neck malignancies. This study compared the evaluation of metastasis by palpation, ultrasonography (USG) and computed tomography (CT) in patients with known head and neck malignancies.Twenty-five consecutive patients with head and neck malignancy were prospectively evaluated for the presence of cervical lymphadenopathy and carotid artery invasion. All patients underwent clinical examination (palpation), USG and CT examination. A modified CT c

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Vrînceanu, Daniela, M. Dumitru, and Carmen Maria Ardeleanu. "MALIGNIZED BRANCHIAL CYST OR CERVICAL METASTATIC ADENOPATHY WITH PRIMARY TUMOR IN A TONSILLAR HIDDEN CARCINOMA?" Journal of Surgical Sciences 7, no. 1 (2020): 169–74. http://dx.doi.org/10.33695/jss.v7i1.306.

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Cancer of occult origin is defined as a group of primary tumors with metastatic determinations, most commonly lymph nodes for which diagnostic algorithms fail to identify the place of origin of the primary tumor at the time of positive metastasis diagnosis. Squamous cell carcinoma with a truly unknown primary office is a relatively rare entity in the region of the head and neck. Retrospective studies suggest that it accounts for 1-3% of new cases of squamous cell carcinoma of the head and neck. We will present the clinical case of a 76-year-old patient with metastatic left-cervical cystic meta

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Chang, Victor Ken On, and Samuel Thambar. "TMJ pain as a presentation of metastatic breast cancer to the right mandibular condyle." BMJ Case Reports 14, no. 3 (2021): e241601. http://dx.doi.org/10.1136/bcr-2021-241601.

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Cancer metastasis to the oral and maxillofacial region is uncommon, and metastasis to the mandibular condyle is considered rare. We present a case of a 56-year-old woman with a history of invasive ductal cell carcinoma of the right breast, 10 years in remission, presenting with a 6-month history of symptoms typical of temporomandibular joint (TMJ) dysfunction. Imaging revealed an osteolytic lesion of her right TMJ and subsequent open biopsy confirmed the diagnosis of metastatic breast cancer. Despite the rarity of metastatic cancer to the head and neck region, it is still important for clinici

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Akter, Sylvia, Mansur Alam, and Saleh Akram. "Detection of Primary Sites in Cervical Lymphnode Metastases." Bangladesh Journal of Otorhinolaryngology 30, no. 2 (2025): 76–83. https://doi.org/10.3329/bjo.v30i2.80469.

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Background: A common denominator to all malignancy is their ability to metastasize. Some tumours have the propensity to extensive local invasion without metastasis, whereas others metastasize early on in their development. With the exception of distant metastasis, the presence of cervical lymph node metastasis is the single most adverse independent prognostic factor in head and neck squamous cell carcinoma. Methods: This was a cross sectional study. Sixty (60) patients were studied in Department of Otolaryngology-Head & Neck Surgery, Combined Military Hospital, Dhaka, from July 2021 to Jun

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25

Li, Hui, Hoi-Lam Ngan, Yuchen Liu, et al. "Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes." Cancers 12, no. 10 (2020): 2935. http://dx.doi.org/10.3390/cancers12102935.

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Immunocompetent metastatic head and neck cancer (HNC) models, although scarce, can help understanding cancer progression and therapy responses in vivo. Their comprehensive genome characterizations are essential for translational research. We first exome-sequenced the two most widely used spontaneous metastatic immunocompetent models, namely AT-84 and SCC VII, followed by comprehensive genomic analyses with three prior-sequenced models (MOC2, MOC2-10, and 4MOSC2), together with patient tumors for utility assessment. AT-84 and SCC VII bear high HNC tumor resemblance regarding mutational signatur

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26

Ballal, Sanjana, Madhav P. Yadav, Frank Roesch, et al. "Head-to-Head Comparison between [68Ga]Ga-DOTA.SA.FAPi and [18F]F-FDG PET/CT Imaging in Patients with Breast Cancer." Pharmaceuticals 16, no. 4 (2023): 521. http://dx.doi.org/10.3390/ph16040521.

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This study aimed to compare the diagnostic performance of [68Ga]Ga-DOTA.SA.FAPi with that of [18F]F-FDG PET/CT in detecting primary and metastatic lesions of breast cancer. [18F]F-FDG and [68Ga]Ga-DOTA.SA.FAPi PET/CT scans of histologically proven breast cancer patients were compared according to patient-based and lesion-based analysis. Forty-seven patients with a mean age of 44.8 ± 9.9 years (range: 31–66 years) were evaluated. A total of 85% of patients had invasive ductal carcinoma, and 15% had invasive lobular carcinoma. The tracer uptake [SULpeak, SULavg, and the median tumor-to-backgroun

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27

Bachar, Gideon, Aviram Mizrachi, Naomi Rabinovics, et al. "Prognostic Factors in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck." Ear, Nose & Throat Journal 95, no. 10-11 (2016): 1–10. http://dx.doi.org/10.1177/0145561316095010-1106.

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Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challengedue to its aggressive biologic behavior. We conducted a retrospective study of71 patients—58 men and 13 women, aged 28 to 88 years (mean: 71)—who had been treated atour university-affiliated tertiary care medical center for metastatic cutaneous SCCover a 15-year period. In addition to demographic data, we compiled and analyzed information on tumor characteristics, the site and extent of metastasis, treatment, follow-up, and outcome. Among the tumor factors, poorly differentiated car

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Closca, Raluca-Maria, Adrian Nicoara, Marina Rakitovan, Ion Cristian Mot, and Flavia Baderca. "Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge." Diagnostics 13, no. 23 (2023): 3513. http://dx.doi.org/10.3390/diagnostics13233513.

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Metastatic disease is a complex and sequential process that involves the migration of tumor cells from the primary site to distant areas. This metastatic pathway is not always predictable. Therefore, this paper presents three rare cases of unusual metastases, due to their primary site: two metastases of a clear cell renal cell carcinoma, one gingival, and one nasal, as well as a mandibular metastasis of a hepatocellular carcinoma. In all cases, an incisional biopsy was performed in order to find out the diagnosis. After microscopical examination of morphological Hematoxylin and Eosin-stained s

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Vengathajalam, Selvamalar, and Norhafiza Mat Lazim. "Head and Neck Cancer with Lung Metastases: Treatment Challenges." Clinical Cancer Drugs 6, no. 1 (2019): 48–53. http://dx.doi.org/10.2174/2212697x06666190701113911.

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Background:Head and neck cancer has predilection of metastasising to the lung, bones or liver. The site of metastasis usually depends on the primary tumour location, the staging and the regional spread of the tumour. Patients with distant metastasis are predicted to have a poor prognosis with low survival rate. Oligometastasis is the term used for an intermediate biologic state of restricted metastatic capacity with limited number and sites of organ with metastasis. It is also defined by 5 or less than 5 metastatic lesion in a disease with a controlled primary tumour.Case Reports:In this case

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Scott, A., M. Raine, and J. M. Stansbie. "Ethmoid metastasis of endometrial carcinoma causing mucocoele of maxillary antrum." Journal of Laryngology & Otology 112, no. 3 (1998): 283–85. http://dx.doi.org/10.1017/s0022215100158360.

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AbstractWe report a case of an antral mucocoele secondary to the obstruction of its ostium by metastatic endometrial carcinoma. This is the first report of such a cause for a mucocoele, and for a metastasis from such a tumour in the head and neck.

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Bahig, Houda, Shao Hui Huang, and Brian O’Sullivan. "Oligometastatic Head and Neck Cancer: Challenges and Perspectives." Cancers 14, no. 16 (2022): 3894. http://dx.doi.org/10.3390/cancers14163894.

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A minority of patients with metastatic head and neck squamous cell carcinoma (HNSCC) present with oligometastatic disease. Oligometastasis not only reflects a disease state, but might also present an opportunity for cure in the metastatic setting. Radical ablation of all oligometastatic sites may confer prolonged survival and possibly achieve cure in some patients. However, substantial debate remains about whether patients with oligometastatic disease could benefit from curative intent therapy or whether aggressive treatments expose some patients to futile toxicity. Optimal selection of patien

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Günbay, M. U., K. Ceryan, and A. A. Küpelíjogülu. "Metastatic renal carcinoma to the parotid gland." Journal of Laryngology & Otology 103, no. 4 (1989): 417–18. http://dx.doi.org/10.1017/s0022215100109119.

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AbstractA case of renal carcinoma metastatic to the left parotid gland is presented. A 60-year-old male patient developed a painful mass in his left parotid region one and a half years after he had undergone a left nephrectomy operation for renal carcinoma. The mass was excised surgically. The histopathological diagnosis was metastatic renal carcinoma. From a review of the literature, it is apparent that unlike most of the cases reported, this one had a very aggressive nature. The clinical presentation of the metastasis, and the factors determining the prognosis in cases of metastatic renal ca

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Gil-Julio, Hernani, Fernando Vázquez-Alonso, Antonio J. Fernández-Sánchez, Ignacio Puche-Sanz, José F. Flores-Martín, and José M. Cózar. "Metastasis of Renal Cell Carcinoma to the Buccal Mucosa 19 Years after Radical Nephrectomy." Case Reports in Oncological Medicine 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/823042.

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Renal cell carcinoma (RCC) has high metastatic potential, which requires early diagnosis to optimize the chance of cure. Metastasis of RCC to the head and neck region is less common and metastasis to the buccal mucosa is extremely rare. This phenomenon occurs mostly in patients with generalized dissemination, especially with lung metastases. In this article we report a case of buccal mucosa metastasis from RCC in a 65-year-old man who presented 19 years after undergoing a left radical nephrectomy for clear cell RCC. Surgical excision of the buccal lesion was performed without evidence of recur

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Beckham, Thomas H., Jonathan E. Leeman, Peng Xie, et al. "Long-term survival in patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed therapy." British Journal of Cancer 121, no. 11 (2019): 897–903. http://dx.doi.org/10.1038/s41416-019-0601-8.

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Abstract Background Our objective was to evaluate the outcomes of metastatic head and neck squamous cell carcinoma (HNSCC) by disease burden with an emphasis on metastasis-directed therapy (MDT) in patients with limited metastatic disease burden. Methods In total, 186 patients who developed metastatic disease after definitive therapy for HNSCC were included. Clinically and radiographically apparent metastases were enumerated. Kaplan–Meier methods were used to estimate survival. Cox regression was used to assess the association between clinical variables. Results Patients with a single metastas

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Lele, Saudamini, Natalie Derise, Tara Medlin, Amol Takalkar, and Cherie-Ann Nathan. "Horner Syndrome Secondary to Metastatic Squamous Cell Carcinoma in the Neck: A Case Series." Ear, Nose & Throat Journal 98, no. 4 (2019): 223–26. http://dx.doi.org/10.1177/0145561319838248.

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Background: Horner syndrome caused by metastatic squamous cell carcinoma of the head and neck is not common, and when diagnosed, may have serious clinical implications. We aim at highlighting the clinical significance of this finding. Methods: We retrospectively reviewed charts of 6 patients with Horner syndrome secondary to metastatic head and neck squamous cell carcinoma (HNSCC) in the neck. Results: All 6 patients had pathologically confirmed nodal metastatic HNSCC. There was one unknown primary and in the remaining 5 patients the primary tumor was identified in the oropharynx, larynx, and

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Ozdemir, Savas, Barry McCook, and Christopher Klassen. "Whole-Body versus Routine Skull Base to Mid-thigh 18F-Fluorodeoxyglucose Positron Emission Tomography/ Computed Tomography in Patients with Malignant Melanoma." Journal of Clinical Imaging Science 10 (August 1, 2020): 47. http://dx.doi.org/10.25259/jcis_93_2020.

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Objectives: The objectives of this study are to assess the utility of whole-body 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) (skull vertex to toes) imaging relative to the standard field of view (skull base to mid-thigh) in patients with primary melanoma site that is not located in the lower extremities. Material and Methods: The primary site of the melanoma and metastatic disease was determined based on 18F-FDG PET/CT findings in 26 patients. The FDG avid sites were tabulated as the primary site, lower extremity, brain, and other sites. The hypothe

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Kramer, Dallas E., Mena G. Kerolus, Lee A. Tan, Smita Patel, Vijaya Reddy, and Michael Chen. "Embolization of an Exophytic Posterior Neck Mass Secondary to a Cutaneous Renal Cell Carcinoma Metastasis." Neurointervention 15, no. 3 (2020): 162–66. http://dx.doi.org/10.5469/neuroint.2020.00206.

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Renal cell carcinoma (RCC) commonly metastasizes to the lung, liver, bones, and brain; however, cutaneous metastases remain rare with few reported cases. Since RCCs have the propensity to metastasize to highly vascular areas, the scalp and skin of the head and neck region are likely locations for cutaneous metastases. We report a rare case of a large, exophytic, cauliflower-like, hemorrhagic, metastatic mass of the posterior neck. This is the first reported case of a head and neck cutaneous RCC metastasis treated with endovascular embolization prior to surgical resection. Due to the increased

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Martini, Stefania, Francesca Arcadipane, Pierfrancesco Franco, et al. "Radiation therapy for oligometastatic oropharyngeal cancer." BJR|case reports 6, no. 1 (2020): 20190021. http://dx.doi.org/10.1259/bjrcr.20190021.

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At presentation, isolated metastasis from oropharyngeal squamous cell carcinoma is rare. Liver is a relatively uncommon first site of failure, especially in the absence of other distant metastases, particularly without diagnosis of lung metastases. We report on a case of HPV-related oropharyngeal squamous cell carcinoma with synchronous liver metastasis treated with radiation therapy. This condition, defined as "oligometastatic state," describes a subset of patients with limited volume metastatic disease in whom favorable outcomes were reported with the use of local ablative therapies on both

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Norman, Jordan, Elizabeth Ellison, Jamie Kendrick, Jing He, and Peeyush Bhargava. "FDG Avid Intracholecystic Papillary Neoplasm Mimicking Hepatic Metastasis in a Patient with Head-and-neck Cancer." Indian Journal of Nuclear Medicine 39, no. 2 (2024): 153–54. http://dx.doi.org/10.4103/ijnm.ijnm_150_23.

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Abstract A 75-year-old male with head-and-neck squamous cell cancer received a staging f-18-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET/CT) scan which showed additional focal abnormal uptake in the right hepatic lobe. The patient was treated for probable metastatic disease. Restaging FDG PET/CT scan revealed resolution of uptake in the head-and-neck and persistent focal uptake in the presumed liver metastasis. An abdominal CT with intravenous contrast revealed an enhancing mass in the gallbladder, without extension into the liver. Cholecystectomy revealed

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Lenzi, R., M. Marchetti, and L. Muscatello. "Incidental nodal metastasis of differentiated thyroid carcinoma in neck dissection specimens from head and neck cancer patients." Journal of Laryngology & Otology 131, no. 4 (2017): 368–71. http://dx.doi.org/10.1017/s002221511700024x.

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AbstractBackground:Occult differentiated thyroid carcinomas are not uncommon. The initial presentation of a thyroid carcinoma is often detection of a metastatic cervical lymph node.Methods:A retrospective review was performed of the medical records of 304 patients who underwent neck dissection between 1996 and 2008 for squamous cell carcinoma of the head and neck.Results:Ten patients (3.3 per cent) had nodal metastasis originating from papillary thyroid cancer. All of these patients underwent thyroidectomy and post-operative 131iodine radiometabolic therapy. No patient developed a thyroid tumo

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Lazutkin, Anna, Ron Eliashar, Jeffrey M. Weinberger, and Nir Hirshoren. "Head and neck non-metastatic cancer associated hypercalcemia." International Surgery Journal 6, no. 6 (2019): 2183. http://dx.doi.org/10.18203/2349-2902.isj20192390.

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Cancer associated hypercalemia (CAH) is a relatively common paraneoplastic syndrome and may be associated with head and neck cancer patients. As the hypercalcemia may be life-threatening, recognition is paramount. Herein we investigate the prevalence and outcome metrics of CAH and create a proposed clinical guideline for advanced stage head and neck malignancies. We describe our experience with non-metastatic, asymptomatic persistent head and neck CAH, which resolved after surgical ablation. We have performed a literature search in the PubMed database between the years 1998-2018 using the key

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Aktas, Birol, Mehmet Esat Uygur, Mehmet Salih Soylemez, et al. "Thyroid papillary carcinoma presenting with femoral neck metastasis: a case report." International Journal of Research in Orthopaedics 2, no. 3 (2016): 204. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20163133.

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<p>Thyroid carcinoma is relatively uncommon, accounting for 2% of all cancers. Although they usually present as a neck lump, occasionally they may be presented with a distant metastasis. In this study, a 65 year-old woman was referred to our clinic with a pain on her left hip at both rest and walking. A lytic area at the inferior femoral neck was found with plain radiography. To clarify the characteristics of the lesion, left hip magnetic resonance imaging (MRI) had been performed displaying 3×5 cm hyperintense lesion extending from medial part of the left femoral neck to the left femora

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Mannina, Edward M., Sunanda M. Pejavar, Christine M. Glastonbury, Annemieke van Zante, Steven J. Wang, and Sue S. Yom. "Diagnosis of Bilateral Tonsil Cancers via Staging PET/CT: Case Report and Review." International Journal of Otolaryngology 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/928240.

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Diagnostic workup of metastatic head and neck squamous cell carcinoma of unknown primary site has traditionally included CT and/or MRI imaging and endoscopic biopsies. Routine bilateral tonsillectomy is highly controversial and the role of PET/CT is evolving, both for identification of potential primary sites and the detection of distant metastases. We report a case of cervical nodal metastasis of squamous cell carcinoma from an unknown primary site, in which dual-modality PET/CT led to the unexpected diagnosis of synchronous bilateral tonsillar cancers. In addition, PET/CT correctly distingui

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Toner, G. C., R. L. Thomas, and M. A. Schwarz. "Metastatic bone marrow involvement from supraglottic squamous cell carcinoma." Journal of Laryngology & Otology 103, no. 2 (1989): 225–26. http://dx.doi.org/10.1017/s0022215100108539.

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AbstractA case of an aggressive supraglottic squamous cell carcinoma, which was managed with neo-adjuvant chemotherapy and radical surgery, is described. The post-operative course was of rapid deterioration and death due to progressive metastatic disease involving bone marrow and liver. This is the first reported case of bone marrow infiltration by squamous cell carcinoma of the head and neck diagnosed ante-mortem. The incidence and pattern of metastatic disease from head and neck tumours is reviewed, and the importance of initial staging in determining the risk of distant metastatic disease i

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Chung, Chih-Hung, and Muh-Hwa Yang. "Abstract 1388: Spatial transcriptome analysis of EMT trait and corresponding immune composition study in HNSCC." Cancer Research 84, no. 6_Supplement (2024): 1388. http://dx.doi.org/10.1158/1538-7445.am2024-1388.

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Abstract Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant cancer worldwide. Conventional treatments for this type of cancer involve surgical resection, radiation therapy, and chemotherapy. However, in cases where the tumor recurs or metastasizes distantly, rendering surgical resection or radiation therapy impractical, the only viable option is the utilization of targeted drugs in conjunction with chemotherapy. Despite such interventions, the prognosis remains grim. Hence, the identification of genetic characteristics or biomarkers associated with easy metastasis or recurr

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Vetto, John T., Sancy Ann Leachman, Brooke Middlebrook, et al. "Performance of a 31-gene expression profile (GEP) test for metastatic risk prediction in cutaneous melanomas (CM) of the head and neck." Journal of Clinical Oncology 35, no. 15_suppl (2017): 9576. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.9576.

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9576 Background: Accurate prognostication of distant metastatic risk using sentinel lymph node (SLN) biopsy for CM can be challenging in melanomas of the head and neck due to a higher false negative rate compared to other anatomical areas. A GEP signature that predicts metastatic risk based on primary tumor biology, providing a binary outcome of Class 1 (low risk of metastasis) or Class 2 (high risk), was previously described. The prognostic capabilities of the GEP independently and in combination with SLN status in a cohort of patients with primary head and neck CM are assessed here. Methods:

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Mohd Sabri, Mohd Naqib, Kasumawati Alli, Sze Yin Lam, Kharul Azmi Abdul Kadir, and Norafida Bahari. "RENAL CELL CARCINOMA WITH FACIAL SWELLING AND NASAL OBSTRUCTION AS PRIMARY PRESENTATION." Journal Of Cardiovascular, Neurovascular & Stroke 4, no. 2 (2022): 25–30. http://dx.doi.org/10.32896/cvns.v4n2.25-30.

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Background: Renal cell carcinoma (RCC) is a slow growing tumor. About 25–30% of patients are found to have metastases at diagnosis commonly to lung, liver and bones. The incidence of renal cell carcinoma metastasizing to the head and neck has been reported to range from 15-30%. Intranasal mass, or occasionally orbital mass maybe the presenting symptom of metastatic renal cell carcinoma to the nose and sinuses. Case presentation: We report a case of left RCC with large metastases to the frontonasal region producing head and neck symptoms before the primary lesion could be detected. Clinical pre

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Lezhnev, D. A., A. Yu Vasilyev, E. A. Egorova, et al. "EXAMINATION OF PERIPHERAL LYMPH NODES USING SHEAR WAVE ELASTOGRAPHY IN PATIENTS WITH HEAD AND NECK CANCER." Siberian journal of oncology 18, no. 3 (2019): 5–13. http://dx.doi.org/10.21294/1814-4861-2019-18-3-5-13.

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Between December and September 2018 123 patients with head and neck tumors underwent ultrasound examination. The median age of the patients was 57 years (range 19–76 years). Metastatic lymph nodes were suspected in all patients. A fine needle aspiration biopsy was performed prior to treatment. Aplio 500 (Тoshiba, Japan) ultrasound device was used. According to findings of cytological examination, all patients were divided into 2 groups. Group I consisted of 58 patients with cytologically confirmed metastatic lymph nodes. Group II comprised 65 patients with lymphoid reticular hyperplasia. The v

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Sananmuang, T., S. Prakkamakul, N. Ngampaiboon, S. H. Huang, L. Alshafai, and E. Yu. "Immune Checkpoint Inhibitor: An Emerging Treatment for Head and Neck Cancer. A Primer for the Radiologist." Neurographics 10, no. 5 (2020): 284–301. http://dx.doi.org/10.3174/ng.2000016.

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Immune checkpoint inhibitors have revolutionized treatment in many cancers, including head and neck squamous cell carcinoma. The number of drugs recently approved by the FDA and the European Medicine Agency is growing. Pembrolizumab and nivolumab, which are anti-programmed cell death protein 1 monoclonal antibodies, were first adopted in 2016 as the second-line treatment for recurrent or metastatic head and neck squamous cell carcinoma in patients with disease progression after platinum-based chemotherapy. Recently, pembrolizumab with or without platinum-based chemotherapy was approved as the

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Parikh, Rujul H., Christopher W. Fleming, Chandana A. Reddy, et al. "Single-institute outcomes of palliative chemotherapy in metastatic head and neck squamous cell carcinoma (HNSCC)." Journal of Clinical Oncology 38, no. 15_suppl (2020): e18513-e18513. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e18513.

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e18513 Background: Distantly metastatic HNSCC carries a poor prognosis with limited palliative systemic treatment options and a paucity of literature examining factors impacting outcomes of such therapy. We sought to evaluate characteristics conferring more favorable responses to frontline palliative systemic therapy after distant failure (DF). Methods: From an IRB-approved database, we identified 332 pts with metastatic HNSCC treated from 1999 to 2019. Pts with locoregional HNSCC who developed DF and subsequently were treated with palliative systemic therapy were included. Pts were categorize

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