Academic literature on the topic 'Metastatic Melanoma'

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Journal articles on the topic "Metastatic Melanoma"

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Coelho, Karina Munhoz de Paula Alves, Jaqueline Stall, Bruna Louise Silva, Camila Kricheski, and Paulo Henrique Condeixa de França. "Immunohistochemical overexpression of TWIST1 in metastatic melanomas compared with primary melanomas and nevi." Journal Archives of Health 5, no. 5 (2024): e2395. http://dx.doi.org/10.46919/archv5n5-020.

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Melanoma is an aggressive neoplasia with poor prognosis when not identified and treated early. Phenotypic changes related to melanocytic cell invasion and metastasis have been associated with overexpression of the transcription factor TWIST1, which contributes to upregulation of epithelial-mesenchymal transition in melanoma. We aimed to evaluate the immunohistochemical expression of TWIST1 in nevi, primary melanomas and metastatic melanomas. This is a retrospective cross-sectional study of 71 histological samples with diagnosis of nevus, primary melanoma and metastatic melanoma. The immunohist
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Coelho, Karina Munhoz de Paula Alves, Jaqueline Stall, Bruna Louise Silva, Camila Kricheski, and Paulo Henrique Condeixa de França. "Immunohistochemical overexpression of TWIST1 in metastatic melanomas compared with primary melanomas and nevi." Journal Archives of Health 5, no. 3 (2024): e2395. http://dx.doi.org/10.46919/archv5n3-020.

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Melanoma is an aggressive neoplasia with poor prognosis when not identified and treated early. Phenotypic changes related to melanocytic cell invasion and metastasis have been associated with overexpression of the transcription factor TWIST1, which contributes to upregulation of epithelial-mesenchymal transition in melanoma. We aimed to evaluate the immunohistochemical expression of TWIST1 in nevi, primary melanomas and metastatic melanomas. This is a retrospective cross-sectional study of 71 histological samples with diagnosis of nevus, primary melanoma and metastatic melanoma. The immunohist
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Izraely, Sivan, Shlomit Ben-Menachem, Sapir Malka, et al. "The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway." Cells 12, no. 11 (2023): 1513. http://dx.doi.org/10.3390/cells12111513.

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Previous studies from our lab demonstrated that the crosstalk between brain-metastasizing melanoma cells and microglia, the macrophage-like cells of the central nervous system, fuels progression to metastasis. In the present study, an in-depth investigation of melanoma-microglia interactions elucidated a pro-metastatic molecular mechanism that drives a vicious melanoma-brain-metastasis cycle. We employed RNA-Sequencing, HTG miRNA whole transcriptome assay, and reverse phase protein arrays (RPPA) to analyze the impact of melanoma-microglia interactions on sustainability and progression of four
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Sanchez, Amy A., Tsung-Teh Wu, Victor G. Prieto, Asif Rashid, Stanley R. Hamilton, and Huamin Wang. "Comparison of Primary and Metastatic Malignant Melanoma of the Esophagus: Clinicopathologic Review of 10 Cases." Archives of Pathology & Laboratory Medicine 132, no. 10 (2008): 1623–29. http://dx.doi.org/10.5858/2008-132-1623-copamm.

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Abstract Context.—Primary esophageal melanoma (PEM) is a rare disease and is difficult to distinguish from other esophageal malignancies and from metastatic melanoma. Objective.—To develop diagnostic criteria for PEM, we compared the clinicopathologic features of 5 PEMs and 5 metastatic melanomas to esophagus. Design.—Ten cases of esophageal melanoma, including 4 surgically resected specimens, 2 autopsy cases, and 4 cases reported on mucosal biopsies, were reviewed. The histologic parameters used in this study were well-characterized features for cutaneous melanoma, including junctional compon
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R, Safwate. "Bladder Melanoma." Open Access Journal of Urology & Nephrology 8, no. 1 (2023): 1–3. http://dx.doi.org/10.23880/oajun-16000228.

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Metastatic bladder tumors constitute <5% of all bladder tumors, however metastatic malignant melanoma of the urinary bladder is very rare. The determination of the original focus of metastatic melanomas in urinary bladder is convenient in some cases, where the primary focus is already known from patients reported clinical history. In the presenting case, we report a case of a patient with ocular melanoma with bladder metastasis. To our knowledge, this is the first described case in Morocco. The patient underwent a cystoscopy with Trans Urethral Resection of the bladder, immunohistochemical
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Abubakari, Sumaila, Yeşim Aktürk Dizman, and Filiz Karaman. "Integrated Meta-Analysis Identifies Keratin Family Genes and Associated Genes as Key Biomarkers and Therapeutic Targets in Metastatic Cutaneous Melanoma." Diagnostics 15, no. 14 (2025): 1770. https://doi.org/10.3390/diagnostics15141770.

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Background/Objectives: Cutaneous melanoma is one of the aggressive forms of skin cancer originating from melanocytes. The high incidence of melanoma metastasis continues to rise, partly due to the complex nature of the molecular mechanisms driving its progression. While melanomas generally arise from melanocytes, we investigated whether aberrant keratinocyte differentiation pathways—like cornified envelope formation—discriminate primary melanoma from metastatic melanoma, revealing novel biomarkers in progression. Methods: In the present study, we retrieved four datasets (GSE15605, GSE46517, GS
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Güvenç, Canan, Asier Antoranz, Anna Szumera-Ciećkiewicz, et al. "Road to Metastasis: The TWEAK Pathway as a Discriminant between Metastasizing and Non-Metastasizing Thick Melanomas." International Journal of Molecular Sciences 22, no. 19 (2021): 10568. http://dx.doi.org/10.3390/ijms221910568.

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Cutaneous melanoma (CM) is the most aggressive form of skin cancer, and its worldwide incidence is rapidly increasing. Early stages can be successfully treated by surgery, but once metastasis has occurred, the prognosis is poor. However, some 5–10% of thick (≥2 mm) melanomas do not follow this scenario and run an unpredictable course. Little is known about the factors that contribute to metastasis in some patient with thick melanomas and the lack thereof in thick melanoma patients who never develop metastatic disease. We were therefore interested to study differential gene expression and pathw
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Muto, Yusuke, Taku Fujimura, Yumi Kambayashi, et al. "Metastatic PRAME-Expressing Juvenile Spitzoid Melanoma on the Buttock." Case Reports in Oncology 13, no. 3 (2020): 1141–44. http://dx.doi.org/10.1159/000510261.

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Since the cost of molecular biological methods for Spitzoid neoplasms is expensive, the number of institutes that employ these methods might be limited. Preferentially expressed antigen in melanoma (PRAME) is a tumor-associated antigen that is useful to distinguish melanoma from other melanocytic disorders, including pediatric Spitzoid tumors that are difficult to diagnose by conventional methods alone. In this report, we report a case of PRAME-expressing juvenile Spitzoid melanoma with lymph node metastasis. Unexpectedly, there were few PRAME-expressing cells in the primary tumor, whereas mos
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McRee, Siobhan K., Abraham L. Bayer, Jodie Pietruska, Philip N. Tsichlis, and Philip W. Hinds. "AKT2 Loss Impairs BRAF-Mutant Melanoma Metastasis." Cancers 15, no. 20 (2023): 4958. http://dx.doi.org/10.3390/cancers15204958.

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Despite recent advances in treatment, melanoma remains the deadliest form of skin cancer due to its highly metastatic nature. Melanomas harboring oncogenic BRAFV600E mutations combined with PTEN loss exhibit unrestrained PI3K/AKT signaling and increased invasiveness. However, the contribution of different AKT isoforms to melanoma initiation, progression, and metastasis has not been comprehensively explored, and questions remain about whether individual isoforms play distinct or redundant roles in each step. We investigate the contribution of individual AKT isoforms to melanoma initiation using
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Mathews, Thomas P., Sarah Muh, Arin B. Aurora, and Sean J. Morrison. "Abstract PR017: Differences in melanoma lipid metabolism among distinct metastatic sites." Cancer Research 83, no. 2_Supplement_2 (2023): PR017. http://dx.doi.org/10.1158/1538-7445.metastasis22-pr017.

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Abstract Metastasis is a very inefficient process in which few disseminated cancer cells survive. We developed a patient-derived xenograft assay in which melanomas engraft and spontaneously metastasize (Quintana Nature 456:593-598). Using this assay, we discovered that melanoma cells experience a spike in reactive oxygen species during metastasis and that distant metastasis is limited by oxidative stress (Piskounova Nature 527:186-191). Successfully metastasizing cells undergo reversible metabolic changes during metastasis that increase oxidative stress resistance. For example, melanoma cells
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Dissertations / Theses on the topic "Metastatic Melanoma"

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Kloepping, Kyle Christohper. "Mitochondria-targeted therapy for metastatic melanoma." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5958.

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Melanoma incidence is increasing faster than any other cancer in the world today. Disease detected early can be cured by surgery, but once melanoma progresses to the metastatic stage it is lethal, with an overall median survival of less than one year. The poor prognosis for late stage melanoma patients is attributed to the intrinsic resistance of melanoma to all Federal Drug Administration approved melanoma therapies. Therefore, there is a critical need for novel treatment approaches that circumvent melanoma therapy resistance. Emerging evidence suggests that differences in melanoma metabolism
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Reedy, Jessica Leigh. "Pyridinium derivatives for metastatic melanoma therapy." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/6628.

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Melanoma incidence is increasing faster than any other cancer worldwide.1 Early detection is often curative, but metastatic melanoma is lethal (5-year survival <20%) due to the development of resistance to all approved drugs.1 However, emerging evidence suggests that differences in melanoma metabolism relative to non-malignant cells may provide a target to improve treatment.2-14 Specifically, melanoma cells have increased mitochondrial electron transport chain (ETC) activity, elevated levels of reactive oxygen species, and a simultaneous hyperpolarized mitochondrial membrane potential relative
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Dutton-Regester, Ken. "The identification of therapeutic targets in metastatic melanoma." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53305/1/Ken_Dutton-Regester_Thesis_Final.pdf.

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Metastatic melanoma, a cancer historically refractory to chemotherapeutic strategies, has a poor prognosis and accounts for the majority of skin cancer related mortality. Although the recent approval of two new drugs combating this disease, Ipilimumab and Vemurafenib (PLX4032), has demonstrated for the first time in decades an improvement in overall survival; the clinical efficacy of these drugs has been marred by severe adverse immune reactions and acquired drug resistance in patients, respectively. Thus, understanding the etiology of metastatic melanoma will contribute to the improvement of
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S, Hanekom Gideon. "The detection of occult metastatic disease in patients with cutaneous melanoma." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26789.

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The ability to identify melanoma patients with progressive disease is central to efficient management. The challenge therefore, is to develop prognostic markers and techniques which will allow the identification of those patients whom, at the time of primary tumor diagnosis, already have micrometastases (occult or clinically undetectable metastases). The use of the reverse transcription-PCR (RT-PCR) technique for the detection of circulating melanoma cells (CMCs) is potentially a powerful tool for identifying those patients at risk for developing metastases. The first aim of this study was to
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Sadeghi, Arian. "Adoptive T Cell Therapy for Treatment of Metastatic Melanoma." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-143698.

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Malignant melanoma is a common type of solid tumor that causes high cancer-related mortality in young adults of Northern Europe. The incidence of melanoma increases rapidly which renders us a special responsibility to investigate this disease in depth. One recent promising approach to treat malignant melanoma is adoptive cell therapy with tumor-directed autologous T cells. This thesis aims to improve this therapy in four different studies. We first sought to establish a protocol for the assessment of melanoma-specific T-cell cultures in order to screen for optimal specificity and reactivity in
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Ulloa, Morales Alejandro Jose. "Identification and Characterization of Circular RNAs in Metastatic Melanoma." Thesis, New York University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10846959.

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<p> Advances in next-generation sequencing and algorithm design have revealed the evolutionarily conserved expression of large numbers of circular RNAs (circRNAs) that are endogenous to eukaryotic cells, many being abundant and in some cases the exclusive output of a given gene. CircRNAs are produced when the pre-mRNA splicing machinery &ldquo;backsplices&rdquo; to join a 3&rsquo; downstream splice donor to a 5&rsquo; upstream splice acceptor. Their circular nature gives them superior resistance to exonucleases and extended half-lives when compared to linear RNAs. CircRNAs are produced in a re
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Weight, Ryan Michael. "Photoacoustic detection of metastatic melanoma in the human circulatory system." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4589.

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Thesis (M.S.) University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on August 29, 2007) Vita. Includes bibliographical references.
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Francken, Anne Brecht. "Primary and metastatic melanoma aspects of follow-up and staging /." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/305352393.

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Kanno, Tokuwa. "A metabolomic investigation of Rho-ROCK signalling in metastatic melanoma." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/a-metabolomic-investigation-of-rhorock-signalling-in-metastatic-melanoma(792f264e-a440-4310-8fab-02ff399202de).html.

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Metastatic spread is the cause of 90% of cancer-related deaths. Melanoma cells with high actomyosin contractility, driven by high Rho-Rho Kinase (ROCK) signalling, exhibit a rounded amoeboid type movement and are found at the invasive fronts of primary tumours and in metastases. ROCK is a novel therapeutic target of melanoma as it has recently been shown that small molecule inhibitors of ROCK can reduce melanoma growth and the number of metastases in vivo. -Omics level studies of biological systems are quickly becoming an integral and routine part of biological research. Nuclear Magnetic Reson
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Green, Deborah. "Immunomodulation in metastatic melanoma : an aid to diagnosis and treatment." Thesis, University of London, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518116.

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Books on the topic "Metastatic Melanoma"

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Klein, Sarah A. Metastatic melanoma: Symptoms, diagnoses, and treatments. Nova Science Publishers, 2011.

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1928-, Nathanson Larry, ed. Melanoma research: Genetics, growth factors, metastases, and antigens. Kluwer Academic Publishers, 1991.

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Leong, Stanley P. L. Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer. Kluwer Academic Publishers, 2003.

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Morton, Rachael, ed. Treatment of Metastatic Melanoma. InTech, 2011. http://dx.doi.org/10.5772/1034.

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Advances and Novel Treatment Options in Metastatic Melanoma. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-3303-2.

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Bufalo, Donatella del, Alessandra Carè, and Antonio Facchiano. Advances and Novel Treatment Options in Metastatic Melanoma. Mdpi AG, 2022.

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Preusser, Matthias, Gabriele Schackert, and Brigitta G. Baumert. Metastatic brain tumours. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0019.

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Brain metastasis is a common clinical challenge in cancer patients, particularly those with lung cancer, breast cancer, and melanoma. The prognosis is poor, with median overall survival times measured in months for most patient populations. Established treatments include neurosurgical resection, radiotherapy (including stereotactic radiosurgery and stereotactic radiotherapy, whole-brain radiotherapy, and new radiation techniques), and supportive care measures. Recently, more and more targeted therapies such as EGFR inhibitors, HER2 antagonists, BRAF inhibitors, ALK inhibitors, and immune check
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PALÁCIO, Sarah Brandão, An Young Sarahi Taylor CASTILHO, Francisco Humberto XAVIER JÚNIOR, and Isabella Macário Ferro CAVALCANTI. CANCER STEM CELLS AND CIRCULATING TUMOR CELLS TARGETING BY POLYMERIC NANOPARTICLES FOR METASTATIC MELANOMA TREATMENT. RFB Editora, 2021. http://dx.doi.org/10.46898/rfbe.9786558890249.

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Tilgen, W., and U. Reinhold. Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance. Springer London, Limited, 2012.

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Tilgen, W., and U. Reinhold. Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance. Springer London, Limited, 2011.

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Book chapters on the topic "Metastatic Melanoma"

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Scolyer, Richard A., Klaus J. Busam, and Raymond L. Barnhill. "Metastatic Melanoma." In Pathology of Melanocytic Nevi and Melanoma. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-38385-4_13.

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Ollila, David W., Shachar Laks, and Eddy C. Hsueh. "Surgery for Stage IV Metastatic Melanoma." In Melanoma. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78310-9_28.

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Nebhan, Caroline A., Douglas B. Johnson, Steven A. Deppen, and Anthony B. Daniels. "Surveillance for Metastatic Disease." In Uveal Melanoma. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78117-0_12.

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Choudhary, Maria M., Pierre Triozzi, and Arun D. Singh. "Metastatic Uveal Melanoma." In Clinical Ophthalmic Oncology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54255-8_22.

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Massi, Guido, and Philip E. Leboit. "Cutaneous Metastatic Melanoma." In Histological Diagnosis of Nevi and Melanoma. Steinkopff, 2004. http://dx.doi.org/10.1007/978-3-7985-1943-5_48.

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Busam, Klaus J., and Raymond L. Barnhill. "Metastatic Malignant Melanoma." In Pathology of Melanocytic Nevi and Malignant Melanoma. Springer New York, 2004. http://dx.doi.org/10.1007/978-0-387-21619-5_11.

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Massi, Guido, and Philip E. LeBoit. "Cutaneous Metastatic Melanoma." In Histological Diagnosis of Nevi and Melanoma. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37311-4_51.

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Bernicker, Eric H. "Systemic Therapy for Metastatic Uveal Melanoma." In Uveal Melanoma. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78117-0_15.

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Kroon, Hidde M., Anna M. Huismans, Brendon J. Coventry, and John F. Thompson. "Isolated Limb Infusion for Recurrent and Locally Metastatic Limb Melanoma." In Melanoma. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78310-9_27.

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Johnson, Douglas B., Reinhard Dummer, Keith T. Flaherty, and Keiran S. Smalley. "Targeted Therapies for BRAF-Mutant Metastatic Melanoma." In Cutaneous Melanoma. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-46029-1_40-1.

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Conference papers on the topic "Metastatic Melanoma"

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Grass, David, Georgia M. Beasley, Martin C. Fischer, M. Angelica Selim, and Warren S. Warren. "Melanin imaging with pump-probe microscopy for diagnosis of metastatic melanoma." In CLEO: Applications and Technology. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/cleo_at.2024.ath1b.1.

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Melanoma, the most aggressive skin cancer, is responsible for around 10,000 deaths annually. We are developing a diagnostic biomarker based on femtosecond pump-probe microscopy of melanin, a natural pigment found in most melanoma.
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Fischer, Martin C., David Grass, Anna Sheinberg, et al. "Evaluating metastatic melanoma with optical pump-probe microscopy (Conference Presentation)." In Optical Biopsy XXIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, edited by Robert R. Alfano, Angela B. Seddon, Lingyan Shi, and Binlin Wu. SPIE, 2025. https://doi.org/10.1117/12.3045985.

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Hoskins, Meghan H., Shile Liang, Robert F. Kunz, and Cheng Dong. "Cellular Mechanics and Biology of Tumor Cell-Leukocyte Interactions in the Near Wall Region Under Shear Flow Conditions." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176376.

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Malignant melanoma has a high propensity for metastatic spread, making it the most deadly form of skin cancer. Currently, no effective treatment exists to prevent melanoma metastasis or to inhibit metastatic tumors growing in distant organs [1,2].
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Patel, K., and P. I. Raju. "Metastatic Melanoma of the Trachea." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6795.

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Tsay, Junchieh J., Derrick Raptis, and David R. Schwartz. "Lactic Acidosis In Metastatic Melanoma." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4609.

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Jiang, Jiarui. "Combination Therapies of Metastatic Melanoma and Melanoma Brain Metastases." In The International Conference on Biomedical Engineering and Bioinformatics. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0011255600003443.

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Rosetti, M., A. Larre, M. Forguieri, V. Sartorelli, A. Monte, and F. Coelho. "325 A case study on ovary metastatic melanoma." In IGCS Annual 2019 Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-igcs.325.

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Ji, W., I. Samanta, A. Iardino, H. B. Mahboob, and R. V. Dy. "A Rare Case of Late Endobronchial Metastatic Melanoma." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4944.

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Du, Jiajun, and Lu Wei. "Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma." In Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, edited by Garth J. Simpson, Ji-Xin Cheng, and Wei Min. SPIE, 2021. http://dx.doi.org/10.1117/12.2576833.

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Yep Gamarra, V. F., Y. Paucar, H. A. Aldave, et al. "Metastatic Melanoma Presenting as a Gigant Gastric Ulcer." In ESGE Days 2023. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1765964.

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Reports on the topic "Metastatic Melanoma"

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Biggs, M. W., and J. E. Eiselein. Immunotherapy of metastatic melanoma by reversal of immune suppression. Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/454026.

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Fisher, Darrell R. Development and Testing of a 212Pb/212Bi Peptide for Targeting Metastatic Melanoma. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1054055.

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Marchetti, Dario. Heparanase Mechanisms in Melanoma Brain Metastasis. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613639.

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Marchetti, Dario. Heparanase Mechanisms in Melanoma Brain Metastasis. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada598581.

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Suriyaphol, Gunnaporn. Study the gene expression of E-cadherin, syndecan1, matrix metalloproteinases-2, -7, -9, -14 and tissue inhibitors of metalloproteinases-1 and -2 in canine oral melanoma. Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.80.

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The objectives of this study were to 1.) select the suitable reference genes for quantitative real-time polymerse chain reaction in the most common canine oral cancers: oral melanoma (OM) and oral squamous cell carcinoma (OSCC), 2.) study the gene expression of E-cadherin (CDH1), syndecan 1 (SDC1), matrix metalloproteinases-2, -7, -9, -14 (MMP2, MMP7, MMP9, MMP14) and tissue inhibitors of metalloproteinases-1 and -2 (TIMP1, TIMP2) in canine OM at the mRNA level and study the CDH1, SDC1 and Ki-67 protein expression by immunohistochemistry, and 3.) study the association of gene expression and th
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Metastatic Female Breast Cancer Incidence. National Center for Chronic Disease Prevention and Health Promotion (U.S.). Division of Cancer Prevention and Control., 2024. https://doi.org/10.15620/cdc/174571.

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From 2001 to 2021, a total of 4,652,885 new cases of female breast cancer were reported in the United States. Of these, 260,379 (5.6%) were distant stage (metastatic) at diagnosis. The incidence of metastatic female breast cancer increased from 2001 (5.8 per 100,000 females) to 2021 (7.9 per 100,000). Breast cancer is the second most common cancer among women in the United States (non-melanoma skin cancer is the most common). It is the second leading cause of cancer death among women, after lung cancer. Distant metastatic breast cancer—or cancer that has spread from the breast to distant parts
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