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Journal articles on the topic 'Metastatic Melanoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Coelho, Karina Munhoz de Paula Alves, Jaqueline Stall, Bruna Louise Silva, Camila Kricheski, and Paulo Henrique Condeixa de França. "Immunohistochemical overexpression of TWIST1 in metastatic melanomas compared with primary melanomas and nevi." Journal Archives of Health 5, no. 5 (2024): e2395. http://dx.doi.org/10.46919/archv5n5-020.

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Melanoma is an aggressive neoplasia with poor prognosis when not identified and treated early. Phenotypic changes related to melanocytic cell invasion and metastasis have been associated with overexpression of the transcription factor TWIST1, which contributes to upregulation of epithelial-mesenchymal transition in melanoma. We aimed to evaluate the immunohistochemical expression of TWIST1 in nevi, primary melanomas and metastatic melanomas. This is a retrospective cross-sectional study of 71 histological samples with diagnosis of nevus, primary melanoma and metastatic melanoma. The immunohist

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Coelho, Karina Munhoz de Paula Alves, Jaqueline Stall, Bruna Louise Silva, Camila Kricheski, and Paulo Henrique Condeixa de França. "Immunohistochemical overexpression of TWIST1 in metastatic melanomas compared with primary melanomas and nevi." Journal Archives of Health 5, no. 3 (2024): e2395. http://dx.doi.org/10.46919/archv5n3-020.

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Melanoma is an aggressive neoplasia with poor prognosis when not identified and treated early. Phenotypic changes related to melanocytic cell invasion and metastasis have been associated with overexpression of the transcription factor TWIST1, which contributes to upregulation of epithelial-mesenchymal transition in melanoma. We aimed to evaluate the immunohistochemical expression of TWIST1 in nevi, primary melanomas and metastatic melanomas. This is a retrospective cross-sectional study of 71 histological samples with diagnosis of nevus, primary melanoma and metastatic melanoma. The immunohist

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3

Izraely, Sivan, Shlomit Ben-Menachem, Sapir Malka, et al. "The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway." Cells 12, no. 11 (2023): 1513. http://dx.doi.org/10.3390/cells12111513.

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Previous studies from our lab demonstrated that the crosstalk between brain-metastasizing melanoma cells and microglia, the macrophage-like cells of the central nervous system, fuels progression to metastasis. In the present study, an in-depth investigation of melanoma-microglia interactions elucidated a pro-metastatic molecular mechanism that drives a vicious melanoma-brain-metastasis cycle. We employed RNA-Sequencing, HTG miRNA whole transcriptome assay, and reverse phase protein arrays (RPPA) to analyze the impact of melanoma-microglia interactions on sustainability and progression of four

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4

Sanchez, Amy A., Tsung-Teh Wu, Victor G. Prieto, Asif Rashid, Stanley R. Hamilton, and Huamin Wang. "Comparison of Primary and Metastatic Malignant Melanoma of the Esophagus: Clinicopathologic Review of 10 Cases." Archives of Pathology & Laboratory Medicine 132, no. 10 (2008): 1623–29. http://dx.doi.org/10.5858/2008-132-1623-copamm.

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Abstract Context.—Primary esophageal melanoma (PEM) is a rare disease and is difficult to distinguish from other esophageal malignancies and from metastatic melanoma. Objective.—To develop diagnostic criteria for PEM, we compared the clinicopathologic features of 5 PEMs and 5 metastatic melanomas to esophagus. Design.—Ten cases of esophageal melanoma, including 4 surgically resected specimens, 2 autopsy cases, and 4 cases reported on mucosal biopsies, were reviewed. The histologic parameters used in this study were well-characterized features for cutaneous melanoma, including junctional compon

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R, Safwate. "Bladder Melanoma." Open Access Journal of Urology & Nephrology 8, no. 1 (2023): 1–3. http://dx.doi.org/10.23880/oajun-16000228.

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Metastatic bladder tumors constitute <5% of all bladder tumors, however metastatic malignant melanoma of the urinary bladder is very rare. The determination of the original focus of metastatic melanomas in urinary bladder is convenient in some cases, where the primary focus is already known from patients reported clinical history. In the presenting case, we report a case of a patient with ocular melanoma with bladder metastasis. To our knowledge, this is the first described case in Morocco. The patient underwent a cystoscopy with Trans Urethral Resection of the bladder, immunohistochemical

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Abubakari, Sumaila, Yeşim Aktürk Dizman, and Filiz Karaman. "Integrated Meta-Analysis Identifies Keratin Family Genes and Associated Genes as Key Biomarkers and Therapeutic Targets in Metastatic Cutaneous Melanoma." Diagnostics 15, no. 14 (2025): 1770. https://doi.org/10.3390/diagnostics15141770.

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Background/Objectives: Cutaneous melanoma is one of the aggressive forms of skin cancer originating from melanocytes. The high incidence of melanoma metastasis continues to rise, partly due to the complex nature of the molecular mechanisms driving its progression. While melanomas generally arise from melanocytes, we investigated whether aberrant keratinocyte differentiation pathways—like cornified envelope formation—discriminate primary melanoma from metastatic melanoma, revealing novel biomarkers in progression. Methods: In the present study, we retrieved four datasets (GSE15605, GSE46517, GS

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Güvenç, Canan, Asier Antoranz, Anna Szumera-Ciećkiewicz, et al. "Road to Metastasis: The TWEAK Pathway as a Discriminant between Metastasizing and Non-Metastasizing Thick Melanomas." International Journal of Molecular Sciences 22, no. 19 (2021): 10568. http://dx.doi.org/10.3390/ijms221910568.

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Cutaneous melanoma (CM) is the most aggressive form of skin cancer, and its worldwide incidence is rapidly increasing. Early stages can be successfully treated by surgery, but once metastasis has occurred, the prognosis is poor. However, some 5–10% of thick (≥2 mm) melanomas do not follow this scenario and run an unpredictable course. Little is known about the factors that contribute to metastasis in some patient with thick melanomas and the lack thereof in thick melanoma patients who never develop metastatic disease. We were therefore interested to study differential gene expression and pathw

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8

Muto, Yusuke, Taku Fujimura, Yumi Kambayashi, et al. "Metastatic PRAME-Expressing Juvenile Spitzoid Melanoma on the Buttock." Case Reports in Oncology 13, no. 3 (2020): 1141–44. http://dx.doi.org/10.1159/000510261.

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Since the cost of molecular biological methods for Spitzoid neoplasms is expensive, the number of institutes that employ these methods might be limited. Preferentially expressed antigen in melanoma (PRAME) is a tumor-associated antigen that is useful to distinguish melanoma from other melanocytic disorders, including pediatric Spitzoid tumors that are difficult to diagnose by conventional methods alone. In this report, we report a case of PRAME-expressing juvenile Spitzoid melanoma with lymph node metastasis. Unexpectedly, there were few PRAME-expressing cells in the primary tumor, whereas mos

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9

McRee, Siobhan K., Abraham L. Bayer, Jodie Pietruska, Philip N. Tsichlis, and Philip W. Hinds. "AKT2 Loss Impairs BRAF-Mutant Melanoma Metastasis." Cancers 15, no. 20 (2023): 4958. http://dx.doi.org/10.3390/cancers15204958.

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Despite recent advances in treatment, melanoma remains the deadliest form of skin cancer due to its highly metastatic nature. Melanomas harboring oncogenic BRAFV600E mutations combined with PTEN loss exhibit unrestrained PI3K/AKT signaling and increased invasiveness. However, the contribution of different AKT isoforms to melanoma initiation, progression, and metastasis has not been comprehensively explored, and questions remain about whether individual isoforms play distinct or redundant roles in each step. We investigate the contribution of individual AKT isoforms to melanoma initiation using

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10

Mathews, Thomas P., Sarah Muh, Arin B. Aurora, and Sean J. Morrison. "Abstract PR017: Differences in melanoma lipid metabolism among distinct metastatic sites." Cancer Research 83, no. 2_Supplement_2 (2023): PR017. http://dx.doi.org/10.1158/1538-7445.metastasis22-pr017.

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Abstract Metastasis is a very inefficient process in which few disseminated cancer cells survive. We developed a patient-derived xenograft assay in which melanomas engraft and spontaneously metastasize (Quintana Nature 456:593-598). Using this assay, we discovered that melanoma cells experience a spike in reactive oxygen species during metastasis and that distant metastasis is limited by oxidative stress (Piskounova Nature 527:186-191). Successfully metastasizing cells undergo reversible metabolic changes during metastasis that increase oxidative stress resistance. For example, melanoma cells

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11

Pinto Torres, Simão, Teresa André, Emanuel Gouveia, Lívio Costa, and Maria José Passos. "Systemic Treatment of Metastatic Conjunctival Melanoma." Case Reports in Oncological Medicine 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/4623964.

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Conjunctival melanoma (CM) is an exceptionally rare tumor, with a propensity for local and distant recurrence, with the lungs, skin, liver, and brain being the most common sites of metastasis. Recent progress in systemic treatments, with checkpoint inhibitors and targeted therapies blocking BRAF and MEK, has redefined the standard of care of advanced unresectable and metastatic melanoma. Although most trials did not include patients with conjunctival melanoma, its close molecular and genetic relationship to cutaneous melanoma might suggest a similar response to these novel agents. The authors

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Pajek, Sarah, Walter Cisneros Lopez, Juliet Ray, and Rennier A. Martinez. "Undetected metastatic melanoma in the colon." BMJ Case Reports 17, no. 11 (2024): e258953. http://dx.doi.org/10.1136/bcr-2023-258953.

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Colonic melanoma is a rarely detected aetiology of small bowel obstruction. This is a case of a male in his 80s with a history of treated stage IIIA melanoma on his trunk 7 years prior who presented with small bowel obstruction. He underwent urgent surgical intervention, where a partial colectomy was performed. Pathology revealed a 4.6 cm melanoma causing intussusception. This case highlights the insidious nature of metastatic melanomas and discusses an uncommon location of melanoma metastasis that evaded detection until a late stage.

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13

Song, Kyu Young, Sabina Desar, Thomas Pengo, Ryan Shanley, and Alessio Giubellino. "Correlation of MET and PD-L1 Expression in Malignant Melanoma." Cancers 12, no. 7 (2020): 1847. http://dx.doi.org/10.3390/cancers12071847.

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The proto-oncogene MET, the hepatocyte growth factor (HGF) receptor, is a transmembrane receptor tyrosine kinase (RTK) with a prominent role in tumor metastasis and resistance to anti-cancer therapies. Melanoma demonstrates relatively frequent MET aberrations, including MET gene amplification. Concurrently, programmed death-ligand 1 (PD-L1), with its ability to evade anti-tumor immune responses, has emerged as a prominent therapeutic target in melanoma and other malignancies and its expression is used as a predictive biomarker of response to immunotherapy. We performed immunohistochemistry ana

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14

Rajendharan, Keerthi Andi, Gurushankari Balakrishnan, Sudharsanan Sundaramurthi, Balamourougan Krishnaraj, and Sarath Chandra Sistla. "Ileal intussusception due to primary intestinal melanoma with generalized lymph node metastases- a rare cause of small bowel obstruction." International Surgery Journal 8, no. 2 (2021): 739. http://dx.doi.org/10.18203/2349-2902.isj20210394.

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Primary melanomas of small intestine are rare and most of them are metastases from cutaneous melanoma. The features distinguishing primary from metastatic intestinal melanoma are still under debate. Primary intestinal melanoma (PIM) is associated with a worse prognosis and a more aggressive behaviour due to its rapid growth. Hence, we report a case of primary ileal melanoma presenting as intussusception with generalized lymph node metastasis. A 69-year-old lady presented with recurrent abdominal pain, vomiting, distension and low grade fever. On examination, a 4*4 cm right inguinal lymph node

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15

Rosner, Karli, Darius R. Mehregan, Evangelia Kirou та ін. "Melanoma Development and Progression Are Associated with Rad6 Upregulation andβ-Catenin Relocation to the Cell Membrane". Journal of Skin Cancer 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/439205.

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We have previously demonstrated that Rad6 andβ-catenin enhance each other's expression through a positive feedback loop to promote breast cancer development/progression. Whileβ-catenin has been implicated in melanoma pathogenesis, Rad6 function has not been investigated. Here, we examined the relationship between Rad6 andβ-catenin in melanoma development and progression. Eighty-eight cutaneous tumors, 30 nevi, 29 primary melanoma, and 29 metastatic melanomas, were immunostained with anti-β-catenin and anti-Rad6 antibodies. Strong expression of Rad6 was observed in only 27% of nevi as compared

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16

Aladowicz, Ewa, Letizia Granieri, Federica Marocchi, et al. "ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma." Cancers 12, no. 11 (2020): 3366. http://dx.doi.org/10.3390/cancers12113366.

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Metastases are the primary cause of cancer-related deaths. The underlying molecular and biological mechanisms remain, however, elusive, thus preventing the design of specific therapies. In melanomas, the metastatic process is influenced by the acquisition of metastasis-associated mutational and epigenetic traits and the activation of metastatic-specific signaling pathways in the primary melanoma. In the current study, we investigated the role of an adaptor protein of the Shc family (ShcD) in the acquisition of metastatic properties by melanoma cells, exploiting our cohort of patient-derived xe

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Diaz, Michael J., Angela Fadil, Jasmine T. Tran, et al. "Primary and Metastatic Cutaneous Melanomas Discriminately Enrich Several Ligand-Receptor Interactions." Life 13, no. 1 (2023): 180. http://dx.doi.org/10.3390/life13010180.

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Introduction: Cutaneous melanoma remains a leading cancer with sobering post-metastasis mortality rates. To date, the ligand-receptor interactome of melanomas remains weakly studied despite applicability to anti-cancer drug discovery. Here we leverage established crosstalk methodologies to characterize important ligand-receptor pairs in primary and metastatic cutaneous melanoma. Methods: Bulk transcriptomic data, representing 470 cutaneous melanoma samples, was retrieved from the Broad Genome Data Analysis Center Firehose portal. Tumor and stroma compartments were computationally derived as a

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Li, Xiaowu, Joseph Regezi, F. Patrick Ross та ін. "Integrin αvβ3 mediates K1735 murine melanoma cell motility in vivo and in vitro". Journal of Cell Science 114, № 14 (2001): 2665–72. http://dx.doi.org/10.1242/jcs.114.14.2665.

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The integrin αvβ3 has been shown to be tightly linked to progression of human melanoma. In this study, using two clones from the K1735 murine melanoma system, we investigated the role of αvβ3 in metastasis. The highly metastatic K1735M2 cells express the αvβ3 integrin, whereas the poorly metastatic K1735C23 cells do not. When transduced with the β3 integrin subunit cDNA, the K1735C23 cells produced lung lesions and, in two animals, cardiac metastases, whereas the parental C23 cells did not. By contrast, transduction of the full-length β3 integrin antisense DNA into the K1735M2 cells suppressed

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19

Möller, Tom, and Hans-Joachim Schulze. "The Influence of c-Kit and NRAS Mutation on Patients’ Survival in Metastatic Melanoma Receiving Immune Checkpoint Inhibitors and Chemotherapy." Dermato 2, no. 2 (2022): 53–58. http://dx.doi.org/10.3390/dermato2020006.

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The high metastasis and mortality rates of melanoma in the era of chemotherapy have decreased significantly over the last 10 years. The success is owed largely to the introduction of targeted therapy of oncogenes and immunotherapies, such as checkpoint inhibitors. The aim of the present retrospective, monocentric study is to investigate the impact of chemotherapy or immunotherapy in 550 patients with metastatic melanoma between the years of 2010 and 2019, looking at overall survival while considering BRAF/NRAS/c-KIT mutation status. A total of 17 patients were found to have a c-KIT mutation in

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20

Xie, Hui-Min, Li Li, Seidu A. Richard, Zhigang Lan, and Yuekang Zhang. "Cerebellopontine angle metastatic melanoma mimicking schwannoma in a sexagenarian: Case report." Advances in Bioscience and Clinical Medicine 10, no. 1 (2022): 33–37. http://dx.doi.org/10.7575/aiac.abcmed.v.10n.1p.33.

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Introduction: Metastasis of melanomas to the cerebellopontine angle (CPA) are very rare. Dissemination via blood, cerebrospinal fluid and/or leptomeninges may be the principal pathway for metastatic spread of malignant melanomas to the CPA. Case presentation: A 68-years old man presented with two years history of hearing lost in the right ear with associated dizziness and headaches. A skin lesion was seen on the patient’s right forearm. MRI revealed a nodular abnormal signal intensity at the right CPA which was resected and pathology revealed metastatic melanoma. Conclusion: Aggressive treatme

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Kheir, Wajiha J., Jane S. Kim, and Miguel Angel Materin. "Multiple Uveal Melanoma." Ocular Oncology and Pathology 6, no. 5 (2020): 368–75. http://dx.doi.org/10.1159/000508393.

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Introduction: Multiple uveal melanoma is a rare occurrence and includes bilateral melanoma, unilateral multiple/multifocal melanoma, or melanoma with metastasis to the ipsilateral or contralateral eye. Methods: A chart review of patients diagnosed with uveal melanoma between January 2013 and January 2019 at the Duke University Eye Center Ophthalmic Oncology Service was performed. Results: Three patients with multiple, sequential melanoma were identified; patient 1 had bilateral choroidal melanoma and patients 2 and 3 had 2 choroidal melanomas occurring in the same eye. In all 3 patients, both

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Wang, R., and M. Taniguchi. "Limited T cell antigen receptor repertoire in tumor-infiltrating lymphocyte and inhibition of experimental lung metastasis of murine melanoma by anti-TCR antibody." Journal of Immunology 154, no. 4 (1995): 1797–803. http://dx.doi.org/10.4049/jimmunol.154.4.1797.

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Abstract We analyzed the variability of T cell Ag receptor in tumor-infiltrating lymphocytes in primary and metastatic melanomas. Using a very sensitive inverse/double step PCR, we found the preferential V alpha usage of TCR in tumor-infiltrating lymphocytes in which some TCR sequences were homogenous. However, the profile of TCR V alpha expression was different in primary and metastatic melanomas. V alpha 8+, V alpha 2+, V alpha 4+, and V alpha 3+ TCR were the most dominant repertoires in primary melanoma, whereas V alpha 3+ and V alpha 4+ TCR dominated metastatic melanoma. Depletion of V alp

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Denčić, Tijana, Maja Jovičić-Milentijević, Nataša Vidović, Aleksandar Petrović, and Dušan Mitić. "Cutaneous melanoma metastasis to the large and small intestine: A case report and review of the literature." Acta stomatologica Naissi 39, no. 88 (2023): 2711–17. http://dx.doi.org/10.5937/asn2388711d.

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Introduction: Metastatic melanoma rarely metastasizes to the gastrointestinal tract (GIT). However, melanoma in the gastrointestinal tract is usually of metastatic origin, given that primary melanomas in this location are extremely uncommon. It is very important to differentiate between primary melanoma in the mucosa of the GIT and metastatic melanoma. Case Presentation: A 65-year-old woman with a history of primary cutaneous melanoma in the head region dating back to 2019 developed metastatic melanoma of the large intestine and terminal ileum after two years. Several months later, the patient

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Ramasamy, Villalan, Anand Lakshmanan, Senthilkumaran Govindaraj Raman, and Kannan Devigounder. "Primary malignant melanoma of the duodenum: a rare case report." International Surgery Journal 5, no. 11 (2018): 3771. http://dx.doi.org/10.18203/2349-2902.isj20184663.

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Malignant melanoma especially primary melanoma is uncommon in the gastrointestinal (GI) tract. GI melanomas are usually metastatic from skin melanoma. Anorectal region and small bowel are the most common sites of primary and metastatic GI melanoma respectively. Various theories have been put forward to explain the origin of Primary Melanoma of Small intestine. Melanomas of the GI tract can produce range of symptoms based on their location and size. Surgery is the main stay of treatment for localized disease. We reported a case of primary duodenal melanoma which was managed by surgically.

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Adil, Dehhaze, Daghouri Nada Imane, Labbaci Rim, et al. "Metastatic Melanoma of Unknown Primary." Scholars Journal of Medical Case Reports 11, no. 11 (2023): 2029–33. http://dx.doi.org/10.36347/sjmcr.2023.v11i11.028.

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Metastatic melanoma without a primary is a rare form of skin cancer. Unlike typical melanomas, where the primary tumor is present, metastatic melanoma without a primary is characterized by the presence of metastases without the presence of an identifiable primary tumor. Treatment options depend on the location and extent of metastasis, and advances have been made in the development of targeted therapies. It is important that individuals with risk factors for this disease undergo regular testing for early signs of the disease and that healthcare professionals are aware of this rare disease when

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Damato, Bertil, Antonio Eleuteri, Azzam Taktak, et al. "Deferral of Treatment for Small Choroidal Melanoma and the Risk of Metastasis: An Investigation Using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO)." Cancers 16, no. 8 (2024): 1607. http://dx.doi.org/10.3390/cancers16081607.

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Background: We estimated metastatic-death risk when the treatment of small choroidal melanomas is deferred until growth is observed. Methods: In 24 patients with choroidal melanoma (median diameter 5.85 mm), the exponential growth rate estimated by a mixed-effects model was 4.3% per year. Using the Liverpool Uveal Melanoma Prognosticator Online v.3 (LUMPO3), we measured changes in 15-year metastatic and non-metastatic death risks according to whether the tumor is treated immediately or after observing growth 4 or 12 months later, considering age, sex, and metastasis predictors. Results: In 40-

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Sharma, Samanta, Tian Zhang, Wojciech Michowski, et al. "Targeting the cyclin-dependent kinase 5 in metastatic melanoma." Proceedings of the National Academy of Sciences 117, no. 14 (2020): 8001–12. http://dx.doi.org/10.1073/pnas.1912617117.

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The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors. However, we observed that ablation of CDK5 completely abrogated the metastasis, revealing that CDK5 is essential for the metastatic spread. In mouse and human melanoma cells CDK5 promotes cell invasiveness by directly phosphorylating an intermediate filament protein, vimentin, thereby inhibiting assembly of

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Doepker, Matthew, TzuHua Juan, Dung-Tsa Chen, et al. "Association of pancreatic metastasectomy for melanoma with long-term overall survival: A single-institution experience." Journal of Clinical Oncology 33, no. 3_suppl (2015): 264. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.264.

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264 Background: Isolated metastatic melanoma to the pancreas is extremely rare. A recent pooled analysis evaluated 11 patients(pts) with metastatic melanoma to the pancreas and reported a median disease free interval(DFI) between the diagnosis of the primary cancer to the diagnosis of the isolated pancreatic metastasis of 48 months and a 5-year overall survival(OS) of 27%. The purpose of this study was to review our experience with resection of metastatic melanoma to the pancreas and compare it to the more common metastatic renal cell carcinoma(RCC) to the pancreas. Methods: Pts with pancreati

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Kılıçkaya, M. Mustafa, Giray Aynali, Ali Murat Ceyhan, and Metin Çiriş. "Metastatic Malignant Melanoma of Parotid Gland with a Regressed Primary Tumor." Case Reports in Otolaryngology 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/5393404.

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Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient’s old photographs may help in the detection of preexisting and regressed pigmented lesions in the facial and neck regions.

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Várvölgyi, Tünde, Eszter Anna Janka, István Szász, et al. "Combining Biomarkers for the Diagnosis of Metastatic Melanoma." Journal of Clinical Medicine 13, no. 1 (2023): 174. http://dx.doi.org/10.3390/jcm13010174.

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The early detection of melanoma relapse can improve patient survival; thus, there is a great need for easily accessible biomarkers that facilitate the diagnosis of metastatic disease. We investigated the diagnostic effect of blood biomarkers such as lactate dehydrogenase (LDH), S100B, and osteopontin in the detection of metastases. Clinical data and peripheral blood samples of 206 melanoma patients were collected (no metastasis, N = 120; metastasis, N = 86). The discriminative power of blood biomarkers, patient demographics, and clinicopathological parameters of primary melanomas were evaluate

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Chhabra, Akansha, Vikramjit Mukherjee, Mudit Chowdhary, Mauricio Danckers, and David Fridman. "Black Pleural Effusion: A Unique Presentation of Metastatic Melanoma." Case Reports in Oncology 8, no. 2 (2015): 222–25. http://dx.doi.org/10.1159/000430907.

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Metastatic melanoma is a rare form of skin cancer, but one that comes with a high mortality rate. Pulmonary involvement is frequently seen in metastatic melanoma with only 2% of malignant melanoma patients with thorax metastasis presenting with pleural effusions. Herein, we report an extremely rare case of black pleural effusion from thoracic metastasis of cutaneous malignant melanoma. A 74-year-old man with known metastatic melanoma presented with a 1-month history of worsening lower back and hip pain and was found to have extensive osseous metastatic disease and multiple compression fracture

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Bales, Elise, Lisa Mills, Nancy Milam, et al. "The Low Molecular Weight Cyclin E Isoforms Augment Angiogenesis and Metastasis of Human Melanoma Cells In vivo." Cancer Research 65, no. 3 (2005): 692–97. http://dx.doi.org/10.1158/0008-5472.692.65.3.

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Abstract Immunohistochemical analysis has consistently shown that cyclin E is up-regulated in human malignant melanomas in vivo. Here we analyzed such expression in more detail and show that cyclin E is overexpressed and present in low molecular weight (LMW) isoforms in metastatic melanoma and in a subset of primary invasive melanoma tumor tissues, but not in benign nevi. Human metastatic melanoma cell lines, but not normal melanocytes, also expressed the LMW cyclin E forms. The biological significance of these findings was established by showing that overexpression of two LMW cyclin E forms n

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Hastings, Karen, Jennifer Nguyen, Richard Bernert, Christine Ko, Noemi Sebastiao, and Chengcheng Hu. "Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma (TUM2P.1038)." Journal of Immunology 194, no. 1_Supplement (2015): 69.35. http://dx.doi.org/10.4049/jimmunol.194.supp.69.35.

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Abstract T cell-mediated immunity has the ability to produce durable anti-melanoma responses resulting in improved survival of patients with advanced melanoma. Antigen presentation in the tumor microenvironment directs anti-melanoma T cell responses. Gamma-interferon-inducible lysosomal thiol reductase (GILT) is critical for MHC class II-restricted presentation of multiple melanoma antigens to CD4+ T cells. However, GILT expression in melanoma has not been defined. We evaluated GILT and MHC class II expression in human primary and metastatic melanomas and nevi using immunohistochemistry. Both

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Sendagorta, Elena, Angel Pizarro, Marta Feito, et al. "Diffuse Melanosis and Ascites due to Metastatic Malignant Melanoma." Scientific World JOURNAL 8 (2008): 556–57. http://dx.doi.org/10.1100/tsw.2008.78.

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We present a female patient who developed mucosal and skin hyperpigmentation due to metastatic malignant melanoma. Diffuse cutaneus melanosis is a rare entity that complicates a small percentage of metastatic melanomas, confering a fatal prognosis. We discuss briefly the current evidence on pathogenesis of melanosis arising from metastatic melanoma.

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Thies, Anka, Ingrid Moll, Jürgen Berger, et al. "CEACAM1 Expression in Cutaneous Malignant Melanoma Predicts the Development of Metastatic Disease." Journal of Clinical Oncology 20, no. 10 (2002): 2530–36. http://dx.doi.org/10.1200/jco.2002.05.033.

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PURPOSE: The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma is associated with metastasis. PATIENTS AND METHODS: CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metas

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Leung, Gilberto Ka Kit, Wing Sun Chow, Kathryn Choon Beng Tan, Yiu Wah Fan, and Karen Siu Ling Lam. "Metastatic melanoma of the pituitary gland." Journal of Neurosurgery 99, no. 5 (2003): 913–15. http://dx.doi.org/10.3171/jns.2003.99.5.0913.

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✓ The authors report on the clinical features and imaging studies in a case of metastatic melanoma of the pituitary gland. Cerebral metastatic melanoma and pituitary metastasis from any source are commonly associated with systemic metastasis, whereas pituitary metastatic melanoma without widespread disease dissemination is distinctly rare. This 46-year-old man presented with diabetes insipidus and anterior pituitary dysfunction 5 years after he underwent resection of a cutaneous malignant melanoma of the neck. Magnetic resonance imaging demonstrated the presence of melanin within a sellar tumo

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Kuvshinov, Yu P., M. A. Krylovetskaya, A. O. Bogdanova, et al. "Endoscopic diagnosis of melanoma." Surgical practice (Russia), no. 3 (September 19, 2024): 60–77. http://dx.doi.org/10.5922/2223-2427-2024-9-3-6.

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Background. Although skin melanoma is a tumour which can be localised visually, its current diagnosis remains unsatisfactory. Skin melanoma exhibits an extremely diverse clinical presentation and a highly variable progression of the neoplastic process.Aim. To analyze our experience in diagnosing metastatic melanoma of the gastrointestinal tract.Materials and methods. The paper presents data from endoscopic and morphological studies of 29 patients who were diagnosed with metastatic melanoma with lesions of the gastrointestinal tract at the Department of Endoscopy the N. Blokhin National Medical

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Werner, Franziska, Christine Wagner, Martin Simon, et al. "Loss of Lymphotoxin Alpha-Expressing Memory B Cells Correlates with Metastasis of Human Primary Melanoma." Diagnostics 11, no. 7 (2021): 1238. http://dx.doi.org/10.3390/diagnostics11071238.

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Activated antigen-experienced B cells play an unexpected complex role in anti-tumor immunity in human melanoma patients. However, correlative studies between B cell infiltration and tumor progression are limited by the lack of distinction between functional B cell subtypes. In this study, we examined a series of 59 primary and metastatic human cutaneous melanoma specimens with B cell infiltration. Using seven-color multiplex immunohistochemistry and automated tissue imaging and analysis, we analyzed the spatiotemporal dynamics of three major antigen-experienced B cell subpopulations expressing

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Hu, Feng, Ki On Fong, May P. L. Cheung, et al. "Abstract 5971: DEPDC1B promotes melanoma angiogenesis and metastasis through sequestration of ubiquitin ligase CDC16 to stabilize secreted SCUBE3." Cancer Research 82, no. 12_Supplement (2022): 5971. http://dx.doi.org/10.1158/1538-7445.am2022-5971.

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Abstract The ability of melanoma to acquire metastasis through the induction of angiogenesis is one of the major causes of skin cancer death. Here, we find that high transcript levels of DEPDC1B in cutaneous melanomas are significantly associated with a poor prognosis. Tissue microarray analysis indicates DEPDC1B expression is positively correlated with SOX10 in the different stages of melanoma. Consistently, DEPDC1B is both required and sufficient for melanoma growth, metastasis, angiogenesis, and functions as a direct downstream target of SOX10 to partly mediate its oncogenic activity. In co

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Ng, Chiak Yot, Firdaus Hayati, and Chandran Nadarajan. "Emphysematous gastritis after metastatic malignant melanoma: a radiological surprise." BMJ Case Reports 13, no. 9 (2020): e235174. http://dx.doi.org/10.1136/bcr-2020-235174.

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Malignant melanoma is cancer of the skin which commonly metastasises to the stomach. There have been no reported cases of emphysematous gastritis secondary to metastasis of malignant melanomas, to date. However, a 61-year-old woman with metastatic malignant melanoma of the left great toe presented to us with symptoms of severe left hypochondrium pain associated with high-grade fever, gross abdominal distension and recurrent vomiting. Two months earlier, metastasis was observed to have spread to the stomach and inguinal lymph nodes. At this stage, the patient opted for traditional medication in

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Szabó, Balázs, Miklós Szűcs, András Horváth, et al. "Urogenitalis lokalizációjú mucosamelanoma primer és áttétes esetei klinikánkon." Orvosi Hetilap 160, no. 10 (2019): 378–85. http://dx.doi.org/10.1556/650.2019.31303.

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Abstract: Introduction: Both primary and metastatic cases of mucosal melanoma in urogenital localization are rare tumors. Only 4–5% of all primary melanomas do not arise from the skin. Extracutaneous melanomas have a complex clinical presentation, but these aggressive tumors have a poor prognosis. Materials and method: In our department, we found 7 patients with malignant melanoma of the genitourinary tract in the past few years. The 7 cases were: primary amelanotic melanoma of the female urethra, a primary melanoma of the bladder, two primary melanomas of the penis, a metastatic melanoma of t

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Kumari, Madhu, Sandhya Kumari Sinha, Punam Prasad Bhadani, Avinash Singh, and Tanya Prasad. "Malignant Melanoma Metastasis to Bone Marrow: A Rare Case Report." Journal of Advances in Medicine and Medical Research 35, no. 19 (2023): 251–56. http://dx.doi.org/10.9734/jammr/2023/v35i195157.

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Malignant melanoma is an aggressive neoplasm, its metastasis to bone marrow is rare phenomenon. Here, we are presenting a case of metastatic malignant melanoma to bone marrow with unknown primary in 40 years old patient along with review of literature. This case is diagnosed as metastatic malignant melanoma in bone marrow aspirate and biopsy specimen first. Diagnosis was done on the basis of classical histological features and with the help of immunohistochemistry. Radiological investigations were done to know primary site. Multiple metastasis in liver and vertebra were also identified. USG gu

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Tang, Lihua, Wei Zhang, Bing Su, and Bo Yu. "Long Noncoding RNA HOTAIR Is Associated with Motility, Invasion, and Metastatic Potential of Metastatic Melanoma." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/251098.

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Metastatic melanoma, the primary cause of skin cancer-related death, warrants new therapeutic approaches that target the regulatory machinery at molecular level. While long noncoding RNAs (lncRNAs) are dysregulated in a number of cancer types, limited data are available on the expression and function of lncRNAs in melanoma metastasis. The primary objective of this study was to investigate the role of 6 metastasis-related lncRNAs in pairs of primary melanoma and matched lymph node metastatic tissues. Among the tested lncRNAs, HOTAIR was the most highly expressed in lymph node metastasis. The ro

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Fidler, Isaiah J. "Melanoma Metastasis." Cancer Control 2, no. 5 (1995): 398–404. http://dx.doi.org/10.1177/107327489500200503.

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Cancer metastasis requires a series of sequential steps, each of which is rate limiting. Neoplasms are biologically heterogeneous, and the process of metastasis is highly selective. Multiple metastases often differ in biologic characteristics and can change during the course of the disease. Clonal analysis of human melanoma suggest that systemic, physiologic signals can be recognized by neoplastic cells. Brain metastases are particularly common in patients with metastatic melanoma. The blood brain barrier does not prevent the invasion of the brain parenchyma by circulating metastatic cells, an

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Guglielmi, Loredana, Marta Nardella, Carla Musa, et al. "Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains." Cancers 12, no. 6 (2020): 1635. http://dx.doi.org/10.3390/cancers12061635.

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The identification of liquid biomarkers remains a major challenge to improve the diagnosis of melanoma patients with brain metastases. Circulating miRNAs packaged into tumor-secreted small extracellular vesicles (sEVs) contribute to tumor progression. To investigate the release of tumor-secreted miRNAs by brain metastasis, we developed a xenograft model where human metastatic melanoma cells were injected intracranially in nude mice. The comprehensive profiles of both free miRNAs and those packaged in sEVs secreted by the melanoma cells in the plasma demonstrated that most (80%) of the sEV-asso

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Kinsey, Emily N., and April KS Salama. "Metastatic Uveal Melanoma—A Review of Current Therapies and Future Directions." Oncology & Hematology Review (US) 13, no. 02 (2017): 100. http://dx.doi.org/10.17925/ohr.2017.13.02.100.

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The most common type of ocular melanoma is uveal melanoma, which includes melanomas that originate from the choroid, iris, or ciliary body. Although the survival rate for all cases of uveal melanoma is high, once metastatic disease occurs the survival rate drops dramatically. Currently no standard of care exists to guide management in metastatic uveal melanoma. The molecular biology in uveal melanoma is distinct from cutaneous melanoma. In most cases of uveal melanoma, the mitogen activated protein kinase (MAPK) pathway is activated through mutations in either GNAQ or GNA11. In uveal melanoma

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Chung, Chul Y., Gauruv S. Likhari, Neda Zarrin-Khameh, and Arun C. Nachiappan. "Hyperdense Endobronchial Mass - A Rare Manifestation of Metastatic Melanoma." Journal of Clinical Imaging Science 4 (February 25, 2014): 7. http://dx.doi.org/10.4103/2156-7514.127833.

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Parenchymal lung metastases are common in malignant melanoma. However, endobronchial metastatic melanoma is uncommon. In this report, we describe a patient with a hyperdense endobronchial mass diagnosed as a melanoma metastasis. We review the imaging findings of pulmonary metastatic melanoma and discuss the differential diagnosis of an endobronchial mass in adults.

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Mandaliya, Hiren, Nandini Singh, Sanila George, and Mathew George. "Choroid Melanoma Metastasis to Spine: A Rare Case Report." Case Reports in Ophthalmological Medicine 2016 (2016): 1–2. http://dx.doi.org/10.1155/2016/2732105.

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Metastatic choroid melanoma is a highly malignant disease with a limited life expectancy. The liver is the most common site for metastasis of uveal melanoma followed by lung, bone, skin, and subcutaneous tissue. Metastasis from choroidal melanoma usually occurs within the first five years of treatment for primary tumours. Metastatic choroid melanoma to the spine/vertebrae is extremely rare. We report the first case of spinal metastasis from choroid melanoma in a 61-year-old man who had been treated for primary ocular melanoma three years earlier with radioactive plaque brachytherapy. Synchrono

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Petousis, Vasileios, and Paul T. Finger. "Current Methods for the Diagnosis and Treatment of Choroidal Melanoma." US Ophthalmic Review 05, no. 01 (2012): 62. http://dx.doi.org/10.17925/usor.2012.05.01.62.

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Choroidal melanoma is the most common primary intraocular malignancy. Diagnosis is performed by clinical evaluation: eye cancer specialists currently use multiple diagnostic techniques, including ophthalmoscopy, fundus autofluorescence imaging (FAF), fluorescein angiography (FA), and indocyanine green angiography (ICG), as well as optical coherence tomography (OCT). Tumor biopsy has recently become popular due to the availability of diagnostic cytogenetic features, touted as biomarkers for metastasis. Standard treatments include observation (select small melanomas and indeterminate tumors), ra

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Caruso, James P., Or Cohen-Inbar, Mark H. Bilsky, Peter C. Gerszten, and Jason P. Sheehan. "Stereotactic radiosurgery and immunotherapy for metastatic spinal melanoma." Neurosurgical Focus 38, no. 3 (2015): E6. http://dx.doi.org/10.3171/2014.11.focus14716.

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The management of metastatic spinal melanoma involves maximizing local control, preventing recurrence, and minimizing treatment-associated toxicity and spinal cord damage. Additionally, therapeutic measures should promote mechanical stability, facilitate rehabilitation, and promote quality of life. These objectives prove difficult to achieve given melanoma's elusive nature, radioresistant and chemoresistant histology, vascular character, and tendency for rapid and early metastasis. Different therapeutic modalities exist for metastatic spinal melanoma treatment, including resection (definitive,

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