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Dissertations / Theses on the topic 'Metastatic progression'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Wander, Seth A. "p27 and Metastatic Progression: Molecular Mechanisms Underlying Bone Metastasis." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/690.

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The complex PI3K/mTOR pathway regulates tumor progression via effects on cellular proliferation, apoptosis, autophagy, and motility. New drugs that inhibit the catalytic site of both PI3K and mTOR have shown promise in clinical trials. Here, we report the first use of a novel, dual PI3K/mTOR catalytic site inhibitor (PF-04691502, PF1502) in a xenograft model of breast cancer metastasis to bone. Metastatic MDA-MB-1833 cells showed PI3K/mTOR activation relative to parental MDA-MB-231. Low-dose PF1502 significantly impaired tumor cell motility and invasion in vitro without causing cell cycle arre

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2

Li, Carman Man-Chung. "Transcriptional regulation of metastatic progression in lung adenocarcinoma." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98545.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Lung cancer is the most prevalent cancer type, leading to more than one million deaths per year worldwide. The vast majority of these mortalities were attributed to metastasis, which is the dissemination of tumor cells from the lungs to other organs. The molecular

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3

Donald, Carlton Dewitt. "Metastatic characteristics of tumor progression in Prostate Cancer." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1995. http://digitalcommons.auctr.edu/dissertations/3299.

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Tumor biologist have long appreciated that both cell to cell and cell to extracellular matrix (ECM) interactions are involved in the invasive and metastatic events that are characteristic of malignancy. Cancer cell attachment to and invasion of an ECM has been associated with metastatic potential of cell lines of the Dunning rat prostate model. It was postulated that differences observed in the metastatic potential of four Dunning cell lines may correlate with cell-matrix interactions. Four cell lines, highly metastatic ML, MLL, AT-3 and non-metastatic AT-1 were studied. The adhesive, invasive

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4

Gooding, Alex Joseph. "Characterizing a Role for the lncRNA BORG during Breast Cancer Progression and Metastasis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1528462540265762.

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5

Usmani, Badar Alam. "Genomic instability and the metastatic potential of B16 murine melanomas." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238763.

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6

Mian, Shahid A. "Tissue transglutaminase and its relationship to cell cycle kinetics, apoptosis and tumour progression." Thesis, Nottingham Trent University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360772.

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7

Fiore, Leann S. "A Novel Link Between Abl Family Kinases and NM23-H1 During Metastatic Progression." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacol_etds/5.

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Cancer patient mortality is caused by the ability of tumor cells to invade the extracellular matrix and metastasize. Our lab was the first to identify the role of Abl family of non-receptor tyrosine kinases (c-Abl and Arg) in the progression of solid tumor cancers. In our previous studies, we showed that high c-Abl/Arg activity promotes proliferation, invasion, and metastasis in melanoma and breast cancer cells lines. Here, we demonstrate that our previous findings are clinically relevant by showing increased c-Abl/Arg kinase activity in primary melanoma tumor tissue in comparison to low activ

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8

Fishel, Ben-Kenan Rotem. "Anatomic Patterns of Relapse and Progression Following Treatment with 131I-MIBG in Metastatic Neuroblastoma." Thesis, The University of Arizona, 2018. http://hdl.handle.net/10150/627159.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Purpose and Background: Neuroblastomais the most common pediatric extracranialsolid tumor •50% of patients present with metastatic disease typically involving bone and bone marrow •Despite intensive multimodality therapy, 40% of patients with high-risk neuroblastomawill experience relapse •131I-MIBG is an active salvage agent for relapsed and refractory MIBG-avid disease •It is unknown whether disease progression following 131I-MI

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9

Jones, Robert John. "A study of Src kinase in the regulation of metastatic progression in colorectal cancer." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269495.

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10

Alcock, Helen Elizabeth. "The analysis of genetic change associated with metastatic progression in colorectal and other adenocarcinomas." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392718.

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11

Hyler, Alexandra Rochelle. "Evaluating the Effects of Fluid Shear Stress on Ovarian Cancer Progression and Metastatic Potential." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/94135.

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Most women die of ovarian metastasis rather than the effects of the primary tumor. However, little is known about the factors that support the survival and secondary outgrowth of exfoliated ovarian cancer cells. In addition to genetic and molecular factors, the unique environment of the peritoneal cavity exposes ovarian cells to biophysical forces, particularly fluid shear stress (FSS). These biomechanical forces, only recently identified as a hallmark of cancer, induce rapid signaling events in attached and aggregated cells, a process termed mechanotransduction. The cellular responses to thes

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12

Mathsyaraja, Haritha. "CSF1 DRIVEN TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL ALTERATIONS IN MYELOID CELLS PROMOTE METASTATIC TUMOR PROGRESSION." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1396965183.

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13

Donald, Carlton Dewitt. "Cytoskeletal Dynamics and cellular differentiation influence tumor progression and metastatic potential in Prostate Adenocarcinoma." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1997. http://digitalcommons.auctr.edu/dissertations/3298.

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Cancer cell attachment to and invasion of an extracellular matrix has been associated with metastatic potential. Recently it has become apparent that the extracellular matrix may influence several phenotype properties of metastatic cancer cells. The mechanisms which regulate prostate cancer growth and metastasis may be particularly relevant to the development of clinical strategies for better understanding and ultimate treatment and control of the disease. Cell-matrix interactions of prostate tumor cells were investigated by comparing the invasive ability through and attachment to reconstructe

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14

Flores, Roberto Ettore. "Mycoplasma arginini increases activation, energetic deregulation, and tumor progression of VM-M3 metastatic macrophage cells." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:104072.

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Thesis advisor: Thomas N. Seyfried<br>Mycoplasmas are the smallest, self-replicating free-living prokaryotes, and have been associated with carcinogenesis. Mycoplasmas can be detected in a high percentage of a wide variety of primary human cancers. Some mycoplasma species such as M. fermentans and M. hyorhinis can transform normal murine and human cell lines into tumorigenic cells. Mycoplasma infection can activate oncogenes as well as inactivate tumor suppressor genes. These observations suggest that mycoplasmas can be both carcinogenic and or onco-modulatory. I found that the metastatic macr

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15

Singhal, Mahak [Verfasser], and Ana [Akademischer Betreuer] Martin-Villalba. "Angio-regulation of liver neovascularization and lung metastatic progression / Mahak Singhal ; Betreuer: Ana Martin-Villalba." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1236403088/34.

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16

De, Pitta Cristiano. "microRNAs and breast cancer: a genomic study reveals miR-148b as a major coordinator of tumor progression." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422987.

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Breast cancer is a multistep disease controlled by a wide spectrum of genetic and epigenetic changes occurring within a cell as well as environmental influences; and it is the most common malignancy in women worldwide, often fatal because of metastasis dissemination. Aberrant miRNA expression can influence several gene networks and pathways implicated in tumorigenesis and metastasis formation. To unravel the role of miRNAs during breast cancer progression we investigated miRNA expression in 77 ductal breast carcinoma biopsies and 17 mammoplasties by microarray analysis. Sixteen differentially

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17

Messenger, J. R. "Characterisation of interlenkin-8 signalling in prostate cancer : Implications for the progression to castrate resistant metastatic disease." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517064.

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18

Bhim, Nazreen. "Dysphagia progression-free survival in patients with locally advanced and metastatic oesophageal cancer receiving palliative radiation therapy." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32591.

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Purpose: In patients with advanced oesophageal carcinoma palliation of dysphagia is important to maintaining a reasonable quality of life. The primary aim of this study was to determine the dysphagia progression-free survival (DPFS) in patients with advanced oesophageal carcinoma treated with palliative radiotherapy (RT). Methods: The medical records of all patients with oesophageal carcinoma presenting to Groote Schuur Hospital, Cape Town between January 2015-December 2016 were reviewed and patients who were not candidates for curative treatment and received palliative RT were selected. For t

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19

Sharma, Purva, James Kim, Devapiran Jaishankar, and Sakshi Singal. "EXTENDED PROGRESSION-FREE SURVIVAL ON FIRST LINE TREATMENT WITH DOCETAXEL IN PATIENT WITH METASTATIC TRIPLE NEGATIVE BREAST CARCINOMA." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/43.

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Docetaxel is a chemotherapeutic agent in the taxane group of drugs which is commonly used in the first line setting for metastatic hormone receptor negative breast cancer. We present a case of a 46 year old female who was diagnosed with de novo triple negative metastatic breast carcinoma, and has had an extended progression free survival (PFS) of almost 5 years on first line single agent treatment with Docetaxel. 46 year old female presented with a large left breast mass as well as axillary mass which revealed grade 3 invasive ductal carcinoma of breast on biopsy of both sites. Tumor was estro

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20

RODA, NICOLO'. "SINGLE-CELL TRANSCRIPTIONAL LINEAGE TRACING REVEALS COMPLEXITY AND PLASTICITY OF BREAST CANCER PRO-METASTATIC PHENOTYPES." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/906906.

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Breast cancer (BC) represents a major clinical hurdle, with metastatic outcome accounting for poor patient prognosis. Phenotypic intra-tumor heterogeneity inversely correlates with prognosis in BC and is considered at the basis of metastatization. Traditionally, BC poly-clonal structure was investigated through the genetic barcoding of cells followed by the tracing of the offspring. However, this analysis did not allow a solid investigation of the transcriptional profile associated to clones throughout tumor progression. In this work, we exploited a recently published library of expressed ba

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21

Xu, Wei. "Cytogenetic analysis of a murine mammary carcinoma in vitro and during progression from primary to metastatic growth in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq20717.pdf.

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22

Johnson, Jacqueline Lea. "Matrix Metalloproteinase genes are transcriptionally regulated by E2F transcription factors: a link between cell cycle control and metastatic progression." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4092.

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The RbµE2F transcriptional regulatory pathway plays a critical role in the cell cycle. Rb is inactivated through multiple waves of phosphorylation, mediated mainly by cyclin D and cyclin E associated kinases. Once Rb is inactivated, cells can enter Sµphase. Collectively, three Rb family members and ten E2F proteins coordinate every additional stage of the cell cycle, from quiescence to mitosis. However the RbµE2F pathway is frequently altered in cancer. Aside from cell proliferation, the RbµE2F pathway regulates other essential cellular processes including apoptosis, cell differentiation, angi

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23

Alkhatib, Suehyb. "Characterizing the role of Nucleosome Remodeling Factor (NURF) in tumorigenesis and metastatic progression using mouse models of breast cancer." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/376.

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Increasingly the role of epigenetic machinery as a bridge between underlying DNA sequence and cellular phenotype is being discovered. The establishment of a myriad of unique cellular types sharing identical gene sequences in a multicellular organism gives a broad sense for the inherent role of epigenetic influence on cell differentiation. Importantly, the epigenetic mechanisms involved in establishing cell identity unsurprisingly contribute to diseased states, including cancer. Recent research continues to elucidate contributory roles of epigenetic mechanisms, such as DNA methylation, histone

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24

REGGIANI, FRANCESCA. "GM-CSF AND MMP9 ARE KEY REGULATORS OF THE EFFECT OF ADIPOSE PROGENITORS OVER BREAST CANCER ONSET AND METASTATIC PROGRESSION." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/468900.

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Recent epidemiological and clinical data underlined the critical role of obesity in breast cancer (BC) progression. Among several white adipose tissue (WAT) cells, which may promote a permissive tumor microenvironment, a population with progenitor-like phenotype (CD45-CD34+) was reported to support local and metastatic BC. This population is composed by distinct WAT progenitors: adipose-derived stem cells (ASCs) and endothelial progenitor cells (EPCs), displaying complementary role in BC progression in preclinical models. However, molecular mechanisms involved in this interaction have been so

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25

BERNARDELLI, CLARA. "DIFFERENT EXTRACELLULAR VESICLES SUBPOPULATIONS CHARACTERIZE METASTATIC PROGRESSION: QUALITATIVE AND QUANTITATIVE ANALYSIS OF ISOGENIC MELANOMA CELL LINES AND THEIR SECRETED FACTORS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/559532.

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The survival and proliferation of metastases is a consequence of the pre-metastatic niche (PMN) evolution, an abnormal, tumor growth-favoring microenvironment devoid of cancer cells. Among tumor derived secreted factors, extracellular vesicles (EVs) are key players in PMN establishment and facilitate organotropic metastasis. Compared to normal melanocytes, melanoma cells produce a large quantity of EVs, that can be detected in the plasma of melanoma patients. For this reason, a full characterization of secreted vesicles subpopulations and of their cargo is necessary to understand how EVs affec

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26

Efstathiou, Antonia [Verfasser], and Klaus [Akademischer Betreuer] Pantel. "Potential involvement of Jagged1, integrin alpha5 beta1 and VCAM1 proteins in metastatic progression of human breast carcinomas / Antonia Efstathiou ; Betreuer: Klaus Pantel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/1153124173/34.

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27

Olivera-Salguero, Rubén 1991. "New roles for Snail1 -expressing CAF during primary tumor progression and secondary niche colonization." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/667308.

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Snail1 is the master regulator of the Epithelial-to-Mesenchymal Transition (EMT) and is also crucial for fibroblast activation upon TGFβ signaling. In cancer, Snail1 expression in primary tumors correlates with the appearance of metastasis. We have previously shown that Snail1-expressing cancer-associated fibroblasts (CAF) enhance metastasis. Here we demonstrate that Snail1-expressing CAF attenuate the anti-tumor effector immune response. We observed that Snail1-expressing CAF determine macrophages to present a pro-tumor phenotype in vitro and in the in vivo model of breast cancer MMTV-PyMT wh

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28

Leo, Angela. "The study of cell motility and plasticity in cancer: the role of the crosstalk between BM-MSCs and tumor in osteosarcoma progression and Claisened Hexafluoro as potential inhibitor of amoeboid motility in metastatic melanoma." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1128636.

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Part 1 Growing evidence suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are key players in tumor stroma. Here, we investigated the cross-talk between BM-MSCs and osteosarcoma (OS) cells in tumor progression. We revealed a strong tropism of BM-MSCs towards these tumor cells and identified monocyte chemoattractant protein (MCP)-1, growth-regulated oncogene (GRO)-α and transforming growth factor (TGF)-β1 as pivotal factors for BM-MSC chemotaxis. Once in contact with OS cells, BM-MSCs trans-differentiate into cancer-associated fibroblasts, further increasing MCP-1, GRO-α, inter

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29

Bista, Bigyan R. (Bigyan Raj). "Adhesion-GPCRs in cancer progression and metastasis." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104169.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Adhesion-GPCRs, a novel family of G protein-coupled receptors (GPCRs), are characterized by an extended extracellular region linked to a seven-pass transmembrane moiety via GPCR proteolytic site (GPS)-containing stalk region known as GAIN domain. The name adhesion refers to the presence of functional domains in the extracellular region that commonly mediate cell-cell and cell-matrix interactions in various cont

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30

Lopez, Jose Ignacio. "CD44 Attenuates Metastasis During Breast Cancer Progression." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193882.

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Progression to metastatic disease is the leading cause of deaths resulting from breast cancer. Understanding the mechanisms underlying a cell's ability to move away from its site of origin and populate a distant site is important for the future development of therapies. The interactions between a tumor cell and the microenvironment can modulate a cell's ability to invade through tissues and access distant organs. In this study we present evidence indicating the differential modulation of invasive and proliferative phenotypes by hyaluronan present in the cellular microenvironment.We establis

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31

Marshall, John Francis. "The role of integrins in melanoma progression and metastasis." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295235.

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32

Zaimenko, Inna. "Molecular and metabolic determinants of metastasis development and progression." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19078.

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MACC1, ein Hauptregulator von Metastasen, ist an zahlreichen Kennzeichen von Krebs beteiligt, einschließlich dereguliertem Metabolismus. Dennoch ist seine Rolle im Krebsstoffwechsel unklar. In der vorliegenden Arbeit wurde eine systematische Analyse von MACC1-getriebenen metabolischen Netzwerken durchgeführt. MACC1 erhöhte die GLUT1 auf Zellmembrane, was zu einer erhöhten Glukoseanreicherung, einem erhöhten Glukosefluss und somit zu einer erhöhten Zellproliferation führte. Außerdem, reduzierte MACC1 den Glutaminfluss unabhängig von der Nährstoffverfügbarkeit. Bei Glucoseentzug erhöhte MACC1 di

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33

Minutentag, Iael Weissberg. "Identificação de alterações no transcritoma associadas à progressão metastática em adenocarcinoma de reto." Botucatu, 2019. http://hdl.handle.net/11449/180847.

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Orientador: Sandra Aparecida Drigo Linde<br>Resumo: Introdução: Apesar dos avanços no tratamento, cerca da metade dos pacientes com câncer de reto (CR) desenvolverá metástase à distância. No entanto, as vias biológicas envolvidas na progressão do câncer não são totalmente conhecidas. Neste estudo, investigamos os perfis moleculares e imunológicos em adenocarcinomas de reto relacionados à progressão metastática visando identificar biomarcadores moleculares e/ou alvos terapêuticos. Pacientes e Métodos: O transcritoma de 15 tecidos de CR metastático (M) e não-metastático (NM) pré-tratamento e de

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34

Chin, Nikeisha L. "The Role of Endothelin 3 in Melanoma Progression and Metastasis." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2286.

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Endothelin receptor b (Ednrb) and its ligand Endothelin 3 (Edn3) have been implicated in melanoma. Several studies have shown an upregulation of EDNRB and EDN3 at both the protein and mRNA levels, as melanoma becomes more aggressive. This study investigated the putative role played by Edn3 over-expression in melanoma progression and angiogenesis in vivo. We crossed Tg(Grm1)Epv transgenic mice that aberrantly express metabotropic glutamate receptor1 under the Dopachrome tautomerase promoter, leading to spontaneous melanocytic lesions in the ears and tails that do not metastasize, with transgeni

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Dombrovsky, Alexander. "The effect of vascular aging on cancer progression and metastasis." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96853.

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As one ages, the risk of developing cancer increases. However, the severity and course of the disease can vary greatly at different stages of life. This thesis explores the effects that host age has on blood vessel dependent aspects of the cancer process, such as growth, organ specific metastasis, and tumour responsiveness to antiangiogenic treatments. In the mouse model, older age had a negative impact on tumour growth and lung metastasis; while seemingly the opposite effect is seen with liver metastasis. Also, a targeted, antiangiogenic treatment with Sutent resulted in a greater anti‐tumour

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36

Snyder, Kimberly Ashley. "The role of podocalyxin in breast cancer progression and metastasis." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46014.

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37

Wong, Sunny Y. "Genetic and mechanistic determinants of prostate cancer progression and metastasis." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38626.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2007.<br>Includes bibliographical references.<br>In order to study a complex biological phenomenon such as tumor cell metastasis, one must focus on examining discrete aspects of the process which are amenable to experimentation. In this thesis, I made use of xenograft and spontaneous in vivo mouse models of prostate cancer to approach this problem from two perspectives. First, I sought to identify genes which were involved with metastasis. Second, I focused on the mechanistic elements involved with tumor cell intravasati

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MARTINO, VALENTINA. "THE ROLE OF MIR199A IN BREAST CANCER PROGRESSION AND METASTASIS." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217467.

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Metastasis remains one of the leading causes of death in cancer patients. The epithelial to mesenchymal transition (EMT) is proposed as a preliminary event underlying the metastatic process, allowing tumor cells to migrate and colonize new tissues and organs. EMT is a trans-differentiation program active during embryonic development that produces mesechymal-like cells from epithelial sheets by loss of cell adhesion and leading to increased cell motility. Dissecting molecular pathways associated to EMT and to its metastasis-promoting potential is essential to develop therapeutic strategies agai

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Wu, Ting. "The role of Fibrillarin (FBL) during Human Colorectal Cancer Progression and Metastasis." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10250.

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Le cancer colorectal (CRC) est l'un des cancers les plus fréquemment diagnostiqués dans le monde et représente un défi majeur en santé. Malgré les avancées thérapeutiques, de nombreux défis persistent, soulignant la nécessité de trouver de nouvelles cibles thérapeutiques. La biogenèse des ribosomes et la régulation de la traduction sont des processus essentiels à la survie et à la croissance des cellules cancéreuses. La fibrillarine (FBL), une méthyltransférase nucléolaire, joue un rôle clé dans la production de ribosomes grâce à la méthylation de l'ARN ribosomique (ARNr), nécessaire à l'assem

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Cameron, M. Dianne. "Temporal progression of lung metastasis, cell survival, dormancy and location dependence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/NQ58117.pdf.

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Chu, Chia-Yi. "The Role of Rankl in Prostate Cancer Progression and Bone Metastasis." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/118.

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This study focused on the role of RANKL in prostate cancer EMT progression and metastasis. Activation of RANK, a receptor activator of NF-kB, by its ligand RANKL, in a paracrine manner is responsible for osteoclast differentiation and bone remodeling. RANK activation in cancer cells, however, is thought to be promoted by both autocrine and paracrine mechanisms because RANKL has been shown to be derived from either tumor or its microenvironment, such as osteoblasts, infiltrating inflammatory cells and stromal fibroblasts. In the present study, we demonstrated that autocrine and paracrine RANKL-

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Jenkinson, Sarah Rhiannon. "In vitro models to study the role of S100A4 in mammary epithelial cell metastasis." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367678.

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Ramchandani, Divya. "A Study of Genetic Alterations in Cancer Progression." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439295281.

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BRIVIO, SIMONE. "Molecular mechanisms of cholangiocarcinoma progression: emphasizing the role of tumor-stroma interactions." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199031.

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Il colangiocarcinoma (CCA) è una neoplasia epiteliale che origina dai dotti biliari, ed è caratterizzata da una prognosi infausta, imputabile alla spiccata invasività e alla resistenza alla chemioterapia. L’aggressività delle cellule di CCA è esacerbata dallo stroma desmoplastico che si sviluppa contestualmente alla crescita tumorale, contenente fibroblasti cancro-associati (CAF), macrofagi tumore-associati e cellule endoteliali linfatiche (LEC). Durante il mio dottorato, ho analizzato la natura e la rilevanza biologica dei segnali paracrini intercorrenti tra cellule stromali e tumorali nel CC

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45

Lau, Sze-hang Billy. "Identification and characterization of key genes involved in the development and progression of hepatocellular carcinoma." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38589059.

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Liu, Chia Yi. "Tyrosine Phosphorylation of p68 RNA Helicase Promotes Metastasis in Colon Cancer Progression." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_diss/117.

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The initiation of cancer metastasis usually requires Epithelial-Mesenchymal Transition (EMT), by which tumor cells lose cell-cell interactions and gain the ability of migration and invasion. Previous study demonstrated that p68 RNA helicase, a prototypical member of the DEAD-box RNA helicases, functions as a mediator to promote platelet-derived growth factor (PDGF)-induced EMT through facilitating nuclear translocation of β-catenin in colon cancer cells. In this context, p68 RNA helicase was found to be phosphorylated at the tyrosine 593 residue (referred as phosphor-p68) by c-Abl kinase, and

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SACHDEVA, MOHIT. "MiR-145 is a tumor suppressor in both tumor progression and metastasis." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/dissertations/206.

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MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression at the post-transcriptional level by interacting with the 3'-untranslated region (3'-UTR) of a target gene. Our previous studies indicate that miR-145 is downregulated in breast and colon cancer; moreover, it functions as a tumor suppressor capable of inhibiting tumor cell growth both in vitro and in vivo. In this study, we show that a putative tumor suppressor, miR-145, is regulated through the phosphoinositide-3 kinase (PI-3K)/Akt and p53 pathways. Importantly, p53 transcriptionally induces the expression of miR-145 b

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Piccolella, M. "Caratterizzazione del sistema attivatore del plasminogeno nella progressione metastatica del cancro prostatico umano." Doctoral thesis, Università degli Studi di Milano, 2007. http://hdl.handle.net/2434/166305.

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GnRH analogues are used for the treatment of prostate cancer (PCa) because their ability to suppress the activity of the pituitary-testicular axis, with consequent blockade of testosterone production. However, after an initial responsiveness to hormonal deprivation, PCa progresses and then metastatises. It is known that the system of the plasminogen activator (uPA, uPA inhibitors PAI-1/2 and uPA receptor, uPAR) has been involved in the local degradation of the extracellular matrix and PCa progression and metastases. Studies performed in our laboratory have demonstrated the presence of GnRH rec

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Zhang, Yanyu. "Platelets – Multifaceted players in tumor progression and vascular function." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306129.

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Platelets play a crucial role for blood hemostasis, the process that prevents bleeding. In addition, platelets have been demonstrated to promote cancer progression and cancer related complications like metastasis and thrombosis. Platelets can affect cancer related diseases either directly or by interacting with other blood cells or molecules in the circulation of individuals with cancer. The current thesis addresses the role of platelets in tumor progression and tumor-induced systemic effects of cancer, with a special focus on the effects on the vasculature. In the first paper, the role of pla

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Ahronian, Leanne G. "Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/705.

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Hepatocellular carcinoma (HCC) is a common malignancy of the liver that is one of the most frequent causes of cancer-related death in the world. Surgical resection and liver transplantation are the only curative options for HCC, and tumor invasion and metastasis render many patients ineligible for these treatments. Identification of the mechanisms that contribute to invasive and metastatic disease may enlighten therapeutic strategies for those not eligible for surgical treatments. In this dissertation, I describe two sets of experiments to elucidate mechanisms underlying HCC dissemination, inv

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