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Journal articles on the topic 'Metformin HCL'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Nugrahani, Ilma, Sukmadjaja Asyarie, and Belda Nurmeyna. "Karakterisasi Padatan Mikrosfer Metformin HCl / Alginat-Ca2+ Paut Silang." Acta Pharmaceutica Indonesia 38, no. 1 (2013): 19–25. http://dx.doi.org/10.5614/api.v38i1.5199.

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Telah dilakukan karakterisasi padatan metformin HCl - natrium alginat-Ca2+ paut silang untuk memprediksi kemampuannya menahan pelepasan bahan aktif dikaitkan dengan sifat kristalinitas dan higroskopisitasnya. Karakterisasi mikrosfer dilakukan dengan membandingkan mikrosfer berisi metformin HCl (MDM) dengan persen penjeratan bahan aktif tertinggi yang diperoleh dari optimasi formulasi sebelumnya, mikrosfer tanpa metformin HCl (MTM), dan campuran fisik dari natrium alginat dengan metformin HCl (CF). Selanjutnya setiap sampel dibagi menjadi dua kelompok, yaitu kelompok yang disimpan pada desikato

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2

Karim, Chowdhury Forhadul, Mohammod Jahidul Islam, and Shamima Abdul Rahman. "Metformin HCl Oral Preparation Exhibits Anticancer Activity In-vitro in a Human Non-small Cell Lung Tumour Cell Line." Malaysian Journal of Medicine and Health Sciences 19, no. 3 (2023): 64–71. http://dx.doi.org/10.47836/mjmhs.19.3.9.

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Introduction: The most common variety of lung cancer is non–small cell lung cancer (NSCLC) accounting for 84% of new cases. Surgery, chemotherapy and radiation are the primary treatment option. Metformin has recently been demonstrated to have an anti-tumour impact on various cancer cells. The goal of this investigation was to determine the growth inhibitory, antiproliferative, cytotoxic, apoptotic and cell cycle arrest properties of metformin HCl oral tablets on the A549 lung carcinoma cell line. Methods: The cells were treated with different dosages of an oral preparation of metformin, with u

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3

Imwa, Putra, and Kusumawati Igaw. "THE USE OF CLINOPTILOLITES AS CARRIER OF METFORMIN HYDROCHLORIDE IN DRUG DELIVERY SYSTEM: IN VITRO DRUG RELEASE STUDY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 285. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.24366.

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Objective: As an antidiabetic drug, metformin hydrochloride (HCl) has been well known to possess low oral bioavailability and short half-life. In this study, we prepared the drug delivery system (DDS) of metformin HCl and clinoptilolite as its carrier. The in vitro drug release profile was further investigated.Methods: DDS was made by encapsulating metformin HCl on clinoptilolite using the wet impregnation method at various pH and initial concentration of metformin HCl. Fourier transform infrared spectrometer (FTIR), X-ray diffractometer (XRD), and N2 Sorption Analyzer were used to characteriz

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4

Darusman, Fitrianti, Taufik Muhammad Fakih, and Gina Fuji Nurfarida. "Identification of the Glimepiride and Metformin Hydrochloride Physical Interaction in Binary Systems." Borneo Journal of Pharmacy 4, no. 2 (2021): 110–16. http://dx.doi.org/10.33084/bjop.v4i2.1826.

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Glimepiride is often combined with metformin HCl as an oral antidiabetic in type II diabetes mellitus, which provides a complementary and synergistic effect with multiple targets for insulin secretion. Glimepiride includes class II of BCS, which solubility practically insoluble in water but high permeability, which will impact the drug's small bioavailability. In contrast, metformin HCl includes class III of BCS, which has a high solubility in water, but low permeability is absorbed approximately 50-60% in the digestive tract given orally. The co-crystallization method can be used to improve t

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5

T, Hemant Kumar, and Gowri Sankar D. "RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HCL AND CANAGLIFLOZIN IN PHARMACEUTICAL FORMULATION." INDIAN DRUGS 58, no. 06 (2021): 49–59. http://dx.doi.org/10.53879/id.58.06.10607.

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A simple, specific, accurate, precise and stability-indicating RP-HPLC method was developed and validated for the simultaneous estimation of metformin HCl and canagliflozin in pharmaceutical formulation. The method was developed using the Altima C8 column (150 ×4.6 mm, 0.5 μm) with a mobile phase consisting of acetonitrile and 0.1 % orthophosphoric acid in water (62:38 %V/V) with a flow rate of 1 mL/min. Detection was carried out at 254 nm using a PDA detector. The retention time for metformin HCl and canagliflozin was found to be 2.282 and 3.339 min, respectively. The proposed method was vali

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6

Agus Andrie, Agus, and Anis Yohana Chaerunisa. "REVIEW: PENGGUNAAN MATRIKS PADA SISTEM PELEPASAN EXTENDED RELEASE SEDIAAN TABLET METFORMIN HCL." Medical Sains : Jurnal Ilmiah Kefarmasian 7, no. 3 (2022): 523–34. http://dx.doi.org/10.37874/ms.v7i3.411.

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Terapi farmakologi lini pertama pada pasien diabetes melitus terutama diabetes melitus tipe II pada pasien obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan memiliki banyak kelemahan seperti menimbulkan efek samping dan rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi dengan pelepasan diperpanjang (extended release). Tujuan penulisan review artikel ini adalah memberikan informasi dan gambaran mengenai matriks yang dapat digunakan untuk formulasi tablet metfomin HCl dengan sistem pelep

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Neha, Mochi1 Dr. Rajesh Patel*2. "A Novel RP-HPLC-DAD Method Development and Validation for The Concurrent Quantification of Empagliflozin, Linagliptin and Metformin HCl In a Fixed Dose Combination." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 431–43. https://doi.org/10.5281/zenodo.14609205.

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Purpose: For the simultaneous evaluation of Empagliflozin, Linagliptin, and Metformin HCl in a fixed dose combination, a recently established, precise, fast, accurate, and reliable   RP-HPLC method has been developed and validated.  Methods: Using a Water C18 column (250 mm x 4.6 mm id, 5µ particle size) and an optimized mobile phase combination of 1% orthophosphoric acid: ACN (40:60, %v/v) at a flow rate of 1.0 mL/min, isocratic separation was accomplished using the recommended method. The detection wavelength was determined to be 251 nm. Results: Empagliflozin, Linaglipt

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8

Kharbade, Sukanya, Alpana Asnani, and Kumar Pratyush. "Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Metformin HCl and Repaglinide in Pharmaceutical Formulation." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 344–47. http://dx.doi.org/10.22270/jddt.v9i3.2676.

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Objective: A new, simple, rapid, accurate and economical method have been developed for the simultaneous estimation of Metformin HCl and Repaglinide in formulation. Method: The absorbances of both the drugs were determined at 238 nm and at 294 nm. The linearity was observed in the concentration range of 2-100 µg/ml and 1-35 µg/ml for Metformin HCl and Repaglinide respectively. The method was validated as per ICH guidelines. Result: The recovery of Metformin and Repaglinide was found in the range of 98.24 ± 0.325 to 100.25 ± 0.756. Conclusion: The proposed method was accurate, reproducible and

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9

Hariyadi, Dewi Melani, Noorma Rosita, and Tiara Jeni Rosadi. "Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 5, no. 1 (2019): 13. http://dx.doi.org/10.20473/jfiki.v5i12018.13-19.

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Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs. Objective: The aim of this research was to determine the effect of total amount of metformin HCl on the characteristics of metformin HCl-Ca alginate microspheres using aerosolization technique. Methods: The total amount of metformin were 0.5 g (F1); 1 g (F2); 1.5 g (F3) and 2 g (F4). Drug was encapsulated into alginate and was crosslinked using CaCl2. Results: The results showed that drug loadings were 5.09%;

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10

Junejo, Shizma, Nasim Karim, Muhammad Sajid Abbas Jafri, and Muhammad Arif Razzak. "Clinical Efficacy and Safety of Metformin in Prediabetics." Journal of Saidu Medical College Swat 15, no. 2 (2025): 279–85. https://doi.org/10.52206/jsmc.2025.15.2.1002.

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Background: Prediabetes is defined as a state of abnormal glucose homeostasis, HbA1c 5.7% to 6.4% and fasting blood glucose 100 mg/dl to 125mg/dl. Mainstay of treatment in prediabetes is lifestyle changes. However if not controlled pharmacotherapy is added. Metformin HCL is a biguanide drug.Objectives: To evaluate clinical efficacy of metformin HCl with lifestyle modifications and to assess the adverse effects, safety profile and cost effectiveness of metformin in pre-diabetics. Materials and Methods: This randomized controlled clinical trial (RCT) was conducted at diabetic clinics of National

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11

Nalawade, Vivek, Mohammad A. Shaikh, and Vidula Ghodke. "SPECTROPHOTOMETRIC ESTIMATION AND VALIDATION OF CANAGLIFLOZIN AND METFORMIN HYDROCHLORIDE IN BINARY MIXTURE." INDIAN DRUGS 58, no. 05 (2021): 68–72. http://dx.doi.org/10.53879/id.58.05.11290.

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The purpose of the work was to establish a UV spectroscopic method for the simultaneous estimation of canagliflozin and metformin hydrochloride in a binary mix. This method involves interpretation of simultaneous equations based on measurement of absorbance at two wavelengths, 237 nm and 290 nm, using UV-visible spectrophotometer with 1cm matched quartz cells. Methanol solvent was employed in this method. The developed method obeyed Beer’s-Lambert’s law in the concentration range of 2-12 µg/mL, having correlation coefficient 0.9998 and 0.9994 for canagliflozin and metformin hydrochloride, resp

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12

Upadhyay, Uma, and KS Rathore. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDROCHLORIDE." Pharmaceutical and Chemical Journal 1, no. 2 (2014): 5–13. https://doi.org/10.5281/zenodo.13691319.

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The aim of the current study is to design a sustained release matrix tablet of metformin HCl to maintain plasma level of drug for prolong period of time. Metformin HCl is antihyperglycemic agent used in the treatment of type II Non insulin dependent diabetes mellitus. Sustained release formulation of metformin HCl prolong drug absorption in the upper GI tract and permits once daily dosing in patient with type II diabetes mellitus. This newer formulation may enhance patient compliance compared to conventional immediate release metformin HCl. Metformin HCl present significant challenges due to i

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SushamaAmbadekar1, &. Sameer Keni*2. "RAPID HPLC METHOD FOR IMPURITY PROFILE OF METFORMIN HYDROCHLORIDE IN PRESENCE OFITS COMBINATION DRUGS." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES 5, no. 11 (2018): 150–60. https://doi.org/10.5281/zenodo.1493916.

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A fast and selective method using HPLC was developed for determination of impurity profile of Metformin hydrochloride in the presence of its usual combination of drugs. Antidiabetic combination of drugs like Glipizide, Gliclazide, Glibenclamide, Glimepiride along with Metformin Hydrochloride are available for treatment of diabetic patients in India. A single method of analysis for Impurity profile of Metformin along with each of the four drug combination with Metformin was developed. The method was validated and proved to be specific, precise and robust. Area response was found to be linear in

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14

Polonini, Hudson, Sarah Taylor, and Clark Zander. "Compatibility of Different Formulations in Pentravan® and Pentravan® Plus for Transdermal Drug Delivery." Scientia Pharmaceutica 89, no. 4 (2021): 51. http://dx.doi.org/10.3390/scipharm89040051.

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The potential therapeutic benefit of transdermal delivery systems for some active pharmaceutical ingredients (APIs) has been well-established for decades within the scientific community. However, together with the clinical efficacy, there is the need for an evaluation of the stability of such APIs in bases with known transdermal capabilities, which is necessary to provide the compounding pharmacist with confidence when providing transdermal products. In this study, the stability of danazol, metformin HCl, and resveratrol as individual ingredients, as well as metformin HCl, resveratrol, and Vit

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15

Kerem POLAT, H. "Design of Metformin HCl and Moxifloxacin HCl Loaded Thermosensitive In Situ Gel." Journal of Research in Pharmacy 26(5), no. 26(5) (2022): 1230–41. http://dx.doi.org/10.29228/jrp.215.

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16

Faizan Asad, Faiza Fiaz, Amna Sheraz, Ayesha Nabi Ahmed, Irfan Javaid, and Talib Hussain. "Characterization and stability analysis of metformin HCl microcapsules formulated by complex coacervation technique." Journal of Contemporary Pharmacy 7, no. 1 (2023): 1–7. http://dx.doi.org/10.56770/jcp2023711.

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Objective: Metformin hydrochloride possesses a shorter sort of biological half-life of 1.5–1.6 h with having the absolute type of bioavailability that ranges between 50-60%, the moment it is administered orally. Reduced GIT disturbances and low bioavailability can be optimized by developing microencapsulation of metformin that could prove beneficial. Method: Paraffin oil had been used in obtaining specific types of primary emulsions, whereas the material that was used in the coating of microencapsulation had been identified as sodium alginate. In the process of complex coacervation, a substanc

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Asad, Faizan, Faiza Fiaz, Amna Sheraz, Ayesha Nabi Ahmed, Irfan Javaid, and Talib Hussain. "Characterization and stability analysis of metformin HCl microcapsules formulated by complex coacervation technique." Journal of Contemporary Pharmacy 7, no. 1 (2023): 1–7. http://dx.doi.org/10.56770/jcp.2023711.

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Objective: Metformin hydrochloride possesses a shorter sort of biological half-life of 1.5–1.6 h with having the absolute type of bioavailability that ranges between 50-60%, the moment it is administered orally. Reduced GIT disturbances and low bioavailability can be optimized by developing microencapsulation of metformin that could prove beneficial. Method: Paraffin oil had been used in obtaining specific types of primary emulsions, whereas the material that was used in the coating of microencapsulation had been identified as sodium alginate. In the process of complex coacervation, a substanc

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18

S. Jat, Deepak, Swati G. Talele, Akshada A. Bakliwal, and Anil G. Jadhav. "DESIGN, DEVELOPMENT AND EVALUATION OF ALOGLIPTIN AND METFORMIN HYDROCHLORIDE BILAYER TABLET." Indian Drugs 59, no. 07 (2022): 74–76. http://dx.doi.org/10.53879/id.59.07.12280.

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The objective of the present work was to formulate and evaluate bilayer tablets of alogliptin and metformin HCl. Combining alogliptin with metformin HCL gives additional benefits in comparison with either drug alone and could be considered for patients whose quality of life is impaired by diabetes mellitus. The study was performed to design bilayer tablets of alogliptin immediate release layer and metformin HCl sustained release layer by wet granulation method. The immediate release layer comprised Crospovidone superdisintegrant and sustained release layer comprised HPMC K4M as rate release co

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Permata Hati, Melati, Yandi Syukri, and Bambang Hernawan Nugroho. "Pengaruh Kombinasi Matriks terhadap Karakter Tablet Metformin HCl Lepas Lambat Sistem Floating Effervescent." Pharmaceutical Journal of Indonesia 7, no. 2 (2022): 89–96. http://dx.doi.org/10.21776/ub.pji.2022.007.02.3.

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The research aimed to prepare and evaluate of sustained release metformin HCl tablet with floating system. The tablets were prepared by wet granulation using HPMC K4M and chitosan as matrixes with proportions (w/w) 17.78%:4.44%; 14.44%:7.78%; 11.11%:11.11% ;7.78%;14.44%; 4.44%:17.78%. The tablets were evaluated of weight variation, drug content, hardness, friability, and in vitro floating and drug release studies. The dissolution study had been carried out for 6 hours using USP dissolution apparatus II (paddle) in 900 ml HCl pH 3.0 media at 37±0.50C. All tablet formulas showed closed similarit

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Nasrin, K.*1 Haripriya M.2. "A Novel, Validated UV Spectrophotometric Method For The Simultaneous Estimation Of Metformin Hydrochloride And Empagliflozin In Fixed-Dose Combinations." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 314–30. https://doi.org/10.5281/zenodo.13712011.

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A validated UV spectrophotometric approach has been developed for the concurrent quantification of Metformin HCl and Empagliflozin in both pure powder form and two-component dosage forms using simultaneous equation method. The methodology relies on determining the absorbance of both Metformin HCl and Empagliflozin, in the concentration range of 2-10µg/ml and 0.1-5µg/ml, respectively, at their respective λmax of 234 nm and 224 nm. The correlation coefficient of linearity for Metformin HCl and Empagliflozin in the range 2-10μg/ml and 0.1-5μg/ml was 0.999, 0.998, and 0.99

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Ansary, Johura, Amit Kumar Chaurasiya, and KM Bashirul Huq. "Formulation and evaluation of metformin HCl floating microspheres." Asian Journal of Medical and Biological Research 1, no. 3 (2016): 396–405. http://dx.doi.org/10.3329/ajmbr.v1i3.26445.

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The purpose of the present investigation was the preparation and evaluation of gastro-retentive floating drug delivery system for anti-diabetic drug metformin hydrochloride that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time leading to improve bioavailability. The microspheres were prepared by oil-in-oil emulsion solvent evaporation technique using ethyl cellulose, methacrylic acid copolymer (Eudragit RS100, Eudragit RSPO and Eudragit RLPO). The dried floating microspheres were evaluated for percentage yield (%), actul drug co

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Rao, Y. Madhusudan, Sunil Reddy, Panakanti Pavan Kumar, and Rajanarayana Kandagatla. "Formulation and Release Characteristic of a Bilayer Matrix Tablet Containing Glimepride Immediate Release Component and Metformin Hydrochloride as Sustained Release Component." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 1 (2010): 851–59. http://dx.doi.org/10.37285/ijpsn.2010.3.1.8.

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The aim of present study was to design the concept of bilayered tablets containing Glimepride for immediate release using sodium starch glycolate as super disintegrant and Metformin hydrochloride (HCl) for sustained release by using Hydroxyl propyl methyl cellulose (HPMC K 4M) and Sodium Carboxy Methyl cellulose (SCMC) as the matrix forming polymer, and PVPK-30 as binder. The tablets were evaluated for physicochemical properties. All the values were found to be satisfactory. In vitro release studies were carried out as per USP in pH 1.2 with (0.1% sodium lauryl sulphate w/v) and phosphate buff

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Meena, V. K., and H. R. Ghatak. "Electrochemical Mineralization Kinetics of Metformin." Asian Journal of Chemistry 34, no. 3 (2022): 727–32. http://dx.doi.org/10.14233/ajchem.2022.23618.

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Present work analyzes the kinetic study of mineralization during electro-oxidation on Ti/DSA (Ta2O5-Ir2O5) and combined electro-oxidation and electro-coagulation on stainless steel anode of an antidiabetic drug metformin hydrochloride (MET-HCl) in synthetic wastewater over a specific charge. Four different reaction orders (0.5, 1, 1.5 and 2) were tested using the integral analysis method by plotting TOC concentration terms over specific charges to determine the exact rate kinetics for the mineralization. The effect of applied current density was evaluated at 50 ppm of sodium sulphate as suppor

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L, Subbramanian, M. Anitha Rani, T. Rajasekaran, M. Ramanathan, and P. Solairaj. "Formulation and In-vitro evaluation of liposomal drug delivery system of metformin HCl." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 31–37. http://dx.doi.org/10.22270/jddt.v9i2.2458.

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Metformin is widely used for the treatment of diabetes; the intention of the present study was to formulate Metformin HCl liposomes for a sustained drug delivery system. It have the advantages of dose reduction, less dosing frequency, minimize the side effect, prolong the action of drug and thus achieve better patient compliance. The liposomes were prepared by physical dispersion and ether injection method. Soya lecithin and cholesterol were used for encapsulating the drug, it facilitates to release the medicaments in sustained manner. Chloroform, ether and methanol were used as a solvent. Pho

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Dr.E, Hari Krishna T. Mallika *. DS Spandana M. Harika Raj S. Jyothi. "DEVELOPMENT AND EVALUATION OF METFORMIN HCL LOADED EUDRAGIT®RSPO AND EUDRAGIT®RLPO AND GLIMEPIRIDE BILAYER TABLETS." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3371–80. https://doi.org/10.5281/zenodo.1000995.

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The present study was carried out for developing the formulation of Bilayer tablets of Glimepiride, Metformin HCl. Immediate Release (IR) layer was compressed as direct compression method and Sustained Release (SR) layer blends were compressed by wet granulation method. IR and SR layers were evaluated for pre and post compression studies and all studies were found to be within limits. From dissolution data of Glimepiride Immediate release layer, IR5 formulation was shown maximum drug release at 60 min i.e., 96.4%. Hence IR5was concluded as optimised formulation for IR layer. Sustained layer co

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Ryshchenko, Oksana, Dmytro Lytkin, Illya Podolsky, Alina Volkova, and Inna Vladymyrova. "Monitoring of indicators of physical availibility and socio-economic affordability of metformin hydrochloride medicines." ScienceRise: Pharmaceutical Science, no. 4 (38) (August 29, 2022): 36–43. http://dx.doi.org/10.15587/2519-4852.2022.263675.

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The aim of the study was to monitor the physical availability and socio-economic affordability of metformin hydrochloride medicines, which are used for the treatment of type II diabetes mellitus. Materials and methods. Medical and technological documentation on the standardization of medical care for patients with type II diabetes, data from the State Register of Medicinal Products of Ukraine, software complex “Apteka” of the company “Morion” and data from the pharmaceutical market research analytical company “Pharmstandard” of the company “Morion” were used as research materials to dete

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Oksana, Ryshchenko, Lytkin Dmytro, Podolsky Illya, Volkova Alina, and Vladymyrova Inna. "Monitoring of indicators of physical availibility and socio-economic affordability of metformin hydrochloride medicines." ScienceRise: Pharmaceutical Science, no. 4(38) (August 31, 2022): 36–43. https://doi.org/10.15587/2519-4852.2022.263675.

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<strong>The aim </strong>of the study was to monitor the physical availability and socio-economic affordability of metformin hydrochloride medicines, which are used for the treatment of type II diabetes mellitus. <strong>Materials and methods. </strong>Medical and technological documentation on the standardization of medical care for patients with type II diabetes, data from the State Register of Medicinal Products of Ukraine, software complex “Apteka” of the company “Morion” and data from the pharmaceutical market research analytical company “Pharmstand

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Wanda B. Putri, Friesca S. Nurhaidah, Helmy Yusuf, and Maria L.A.D. Lestari. "Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl." MEDICINUS 36, no. 3 (2023): 36–47. http://dx.doi.org/10.56951/af7svb90.

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The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin

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S., Z. Chemate1 Shruti P. Gosavi*2. "Formulation Development And In-Vitro Evaluation Of Metformin Hydrocholoride And Glibenclamide Buccal Patch." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 482–512. https://doi.org/10.5281/zenodo.10556884.

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In the present study, attempt has been done to develop a novel mucoadhesive drug system in the form of the buccal patches for the release of metformin HCl and glibenclamide in a unidirectional manner, to maintain constant therapeutic levels of the drug for long time. Buccal formulation of metformin HCl and glibenclamide in the form of mucoadhesive patches were developed to a satisfactory level in term of drug release, drug permeation, content uniformity, swelling index, surface pH, thickness and folding endurances. Although all buccal patches exhibited satisfactory results, but best results we

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Waman, Ravi, Gaurav Jain, Jeevan Patel, Ramakant Sharma, Shabnam Khan, and Rakesh Patel. "QbD Approach in Formulation Design and Evaluation of Metformin HCl Tablet." International Journal of Pharmaceutical Sciences and Medicine 7, no. 9 (2022): 27–58. http://dx.doi.org/10.47760/ijpsm.2022.v07i09.004.

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This study reports the QbD Approach in Formulation Design and Evaluation of Metformin HCl Tablet. The concept of quality by design (QbD) has recently gained importance by application of design of experiments approach (DoE). QbD describes a pharmaceutical development approach especially in formulation design & development and manufacturing processes for the purpose of maintaining and improving the product quality. There are various elements of QbD are there such as Quality Target Product Profile (QTPP) ,Critical Quality Attributes (CQAS), Quality Risk (Assessment) Management (QRM), Design S

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Islam, M. A., A. Islam, M. R. I. Khan, R. Sharmin, M. I. I. Wahed, and A. S. M. Anisuzzaman. "Bioequivalence Assessment of Metformin Tablet Formulations of Bangladesh." Journal of Scientific Research 6, no. 3 (2014): 581–88. http://dx.doi.org/10.3329/jsr.v6i3.19290.

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Six marketed oral antidiabetic metformin tablets in Bangladesh have been studied for their drug content, release profile and glucose lowering capacities. This sort of study is a good indicator for in vivo evaluation of the quality of an oral antidiabetic preparation. Marketed preparations of metformin-HCl from different manufacturers were randomly chosen for this study. The drug content was within the United State Pharmacopoeia (USP) specified limit (95-105%) in all cases. The blood glucose levels were investigated in streptozotocin-induced diabetic rats (SIDRs) after 5 hours of single dose (1

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Mazumder, Bhaskar, Khokan Bera, and KhomendraKumar Sarwa. "Metformin HCl loaded mucoadhesive agar microspheres for sustained release." Asian Journal of Pharmaceutics 7, no. 2 (2013): 75. http://dx.doi.org/10.4103/0973-8398.115959.

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Prasad, Garrepally. "Design and Optimization of Metformin Hcl of Colon Targeted Drug Delivery System." Journal of Clinical and Medical Case Reports and Reviews 1, no. 1 (2021): 1–4. http://dx.doi.org/10.59468/2837-469x/001.

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The aim of the present study was to develop colon targeted matrix tablets of Metformin HCl using various conc. of selected polymers such as HPMC, Ethyl Cellulose Guar gum and combination of the same. Tablets were prepared by direct compression method and both pre- compression and post- compression parameters for all batches shows in the acceptable ranges.Short term accelerated stability studies was performed according to ICH guidelines temperature of 400±20 and relative humidity of 75%±5% RH to study any physical changesand chemical decomposition of drug, no formulation shown any physical or c

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K.Manga, M.Sudhakar, K.Meghana, K.Avanthi, and G.Swathi. "Formulation and evaluation of bilayered tablets of sustained release metformin HCl and gliclazide." World Journal of Pharmaceutical Sciences 10, no. 03 (2022): 315–24. http://dx.doi.org/10.54037/wjps.2022.100310.

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The aim of the present work is to formulate and evaluate a bilayered tablet (BT) ofMetformin HCl as Sustained release and Gliclazide as Immediate release (IR). The polymer usedin sustained release is HMPC K100M and the super disintegrate used in immediate release inproportion of Gum Karaka & Croscarmellose sodium by direct compression method. In thisstudy, a bilayered tablet containing Gliclazide in IRL and Metformin in SRL was made using thewet granulation method, with the goal of making the formulations IRL as small as possible, Willrelease Gliclazide as soon as possible to combat postpr

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Patle, Deepshikha, and Manpreet Kaur Deol. "Stability indicating gradient liquid chromatographic technique for the simultaneous estimation of rosiglitazone, glimepiride and metformin HCl in pharmaceutical dosage forms." Indian Journal of Pharmacy and Pharmacology 10, no. 3 (2023): 190–96. http://dx.doi.org/10.18231/j.ijpp.2023.036.

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A stability indicating high performance liquid chromatographic method has been developed and validated for the anti-diabetic drugs Rosiglitazone, Glimepiride, and Metformin HCl in pharmaceutical dosage forms. Chromatographic separation was achieved on Zorbex SB C-8 (250 X 4.6 mm) 5µ and Hypersil BDS C18 (200 × 4 mm), 5μ column as stationary phase. Mobile phase consisting of 0.023M potassium dihydrogen phosphate and acetonitrile (60:40, v/v) supplied at a flow rate of 1ml/min. Detection was performed using a SPD-20A prominence UV/VIS detector at 230 nm. The retention time of rosiglitazone, glim

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Khanduri, Praveen, and Archana Gahtori. "Quantitative UV-Spectrophotometric Method for the Analysis of Teneligliptin HBr and Metformin HCl in Pharmaceutical Dosage form: Development and Validation." Oriental Journal Of Chemistry 40, no. 6 (2025): 1647–52. https://doi.org/10.13005/ojc/400615.

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This study developed a UV-spectrophotometric method for the simultaneous quantification of Metformin HCl and Teneligliptin HBr. Both active pharmaceutical ingredients were found to be soluble in 0.1N sulfuric acid, which was thus chosen as the solvent for analysis. The maximum absorption wavelengths for Metformin HCl and Teneligliptin HBr were identified at 220 nm and 240 nm, respectively. Standard stock solutions were prepared, and samples from commercially available tablets were accurately measured and dissolved for testing. Method validation included evaluations of linearity, precision (int

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Meka, Venkata, Janaki Battu, Senthil Dharmalingam, Adinarayana Gorajana, and Venkata Kolapalli. "Development of a Validated HPLC Method for the Estimation of Metformin HCl and Propranolol HCl." British Journal of Pharmaceutical Research 4, no. 15 (2014): 1909–22. http://dx.doi.org/10.9734/bjpr/2014/10826.

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Merey, Hanan A., Nesrin K. Ramadan, Sherine S. Diab, and Azza A. Moustafa. "Chromatographic methods for the simultaneous determination of binary mixture of Saxagliptin HCl and Metformin HCl." Bulletin of Faculty of Pharmacy, Cairo University 55, no. 2 (2017): 311–17. http://dx.doi.org/10.1016/j.bfopcu.2017.04.002.

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Joshi, H., and A. Khristi. "RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TENELIGLIPTINE HYDROBROMIDE HYDRATE (TEN) AND METFORMIN HYDROCHLORIDE (MET) IN TABLET DOSAGE FORM." INDIAN DRUGS 56, no. 08 (2019): 49–56. http://dx.doi.org/10.53879/id.56.08.11253.

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A simple, accurate, precise, reproducible and economic method developed and validated for the simultaneous estimation of teneligliptine hydrobromide hydrate (TENE) and metformin hydrochloride (MET HCl) in pharmaceutical dosage form. TENE and MET HCl were estimated on Thermoscientific C18 column using mobile phase 0.01M PDP: methanol (45:55 % v/v) (pH 3.5 adjusted with 5% acetic acid) at flow rate 1.0 mL/min. Detection was carried out at 254 nm. The retention time of teneligliptine hydrobromide hydrate and metformin hydrochloride were 7.77 min and 2.64 min, respectively. The linearity was found

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Monali, Chouhan, Revathi A. Gupta Dr., Monika Mann Dr., Anubhav Shrivastava Mr., and Vinay Mahajan Mr. "Formulation, Optimization and Evaluation of Bilayer Tablet of Metformin HCl & Rosuvastatin." Pharmaceutical and Chemical Journal 10, no. 4 (2023): 103–22. https://doi.org/10.5281/zenodo.13997457.

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The aim of present study is to formulate and evaluate the bilayered tablets containing Rosuvastatin as immediate release (IR) portion and Metformin Hydrochloride as sustained release (SR) portion in order to produce a single tablet containing two different classes of drugs as widely prescribed by doctors and to have better patient compliance. The sustained release layer of Metformin HCl was prepared by using different grades of swellable polymer HPMCK4M and HPMC E3 LV, Ethyl Cellulose by wet granulation method. The Immediate release tablets of Rosuvastatin by wet granulation method using vario

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Lee, Soo Hwan, Geun Nyeong Lee, Young Jin Kim, Young Ho Cho, and Gye Won Lee. "Development and Evaluation of Implant using Hot-Melt Extrusion." Yakhak Hoeji 67, no. 1 (2023): 32–44. http://dx.doi.org/10.17480/psk.2023.67.1.32.

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In this study, poly(lactic-co-glycolic acid) (PLGA)-based subcutaneous implant containing metformin HCl was prepared by hot-melt extrusion (HME). This study aimed to evaluate swelling and dissolution behavior for application as subcutaneous implant. Implants containing metformin HCl were fabricated successfully at 30 rpm, 90oC by HME. Drugexcipient compatibility studies through FT-IR and DSC revealed the absence of any interaction between the drug and polymers. Dissolution rate and swelling ratio of metformin HCl was significantly affected by the type of PLGA. Dissolution rate increased as the

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Chowdary, Y. Ankamma, Ramakrishna Raparla, and Muramshetty Madhuri. "Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride." Journal of Pharmaceutics 2014 (May 12, 2014): 1–14. http://dx.doi.org/10.1155/2014/848243.

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In the treatment of type 2 diabetes mellitus a continuous therapy is required which is a more complex one. As in these patients there may be a defect in both insulin secretion and insulin action exists. Hence, the treatment depends on the pathophysiology and the disease state. In the present study, multilayered tablets of pioglitazone hydrochloride 15 mg and metformin hydrochloride 500 mg were prepared in an attempt for combination therapy for the treatment of type 2 diabetes mellitus. Pioglitazone HCl was formulated as immediate release layer to show immediate action by direct compression met

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Valte, Yugesh Balkrishana, Haridas Ajinath Sangale, Harjot Singh Kathuria, Swati Gokul Talele, and Anil Govindrao Jadhav. "Formulation and evaluation of gastro retentive extended release formulation of metformin hydrochloride." GSC Advanced Research and Reviews 2, no. 2 (2020): 008–17. https://doi.org/10.5281/zenodo.4318221.

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The present research think about was to deliver definition and assessment of gastro retentive extended release formulation of metformin hydrochloride. The programming interface metformin hydrochloride and polymer and all excipients were weighed precisely, blended well and by utilizing rotatory pressure machine.(F.P. hardware,accura little press multistation tooling machine) and by utilizing 9mm punch of case shape which has length of 2cm and inside breadth of 9 mm. Utilizing this punch tablets were arranged and continues for promote study. Metformin hydrochloride is hostile to hyperglycaemic s

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DIVYA, Kumble, and Badiadka NARAYANA. "Metformin HCl : Visible Spectrophotometric Determination in Pure and Dosage Form." Journal of Single Molecule Research 2, no. 2 (2014): 14. http://dx.doi.org/10.12966/jsmr.06.01.2014.

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Jain, Abhishek K., and Geeta K. Patel. "FORMULATION AND EVALUATION OF MODIFIED RELEASE TRI-LAYERED TABLET USING A FIXED DOSE COMBINATION OF METFORMIN HCL AND VILDAGLIPTIN." International Research Journal of Pharmacy 11, no. 11 (2020): 54–67. http://dx.doi.org/10.7897/2230-8407.111198.

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The aim of present investigation is to formulate the tri-layered tablet of an Anti-Hyperglycaemic drug comprising Metformin HCl as sustained release layer and Vildagliptin as an immediate release layer in a fixed dose combination along with a fast dissolving intermediate layer or barrier layer in between the two layers just like a sandwich. Vildagliptin is well-known for its instability in presence of Metformin HCl. Hence, Vildagliptin degrades in formulation of single unit dosage form. The in vitro release layer of Metformin HCl was prepared using combination of sustained release polymer HPMC

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Dhage, Shubhangi* Lonkar Sagar Naik Pranav Khaladkar Shraddha. "Matrix-Based Sustained Release Formulations of Metformin Hydrochloride: Current Trends and Evaluation Techniques." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4439–48. https://doi.org/10.5281/zenodo.15522076.

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Metformin hydrochloride (MET) is an oral hypoglycemic agent which improves glucose tolerance in patients with type 2 diabetes and diminishes basal plasma levels of glucose. The aim of this study was to develop and optimize MET matrix tablets for SR application. The SR matrix tablet of MET was prepared by wet granulation technique using Polyvinyl pyrrolidone K30 and hydroxyl propyl methylcellulose of different viscosity grades (HPMC K4M, HPMC K15M, and HPMC K100M). The influence of varying the polymer ratios was evaluated. The excipients used in this study did not modify physicochemical propert

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Harahap, Yahdiana, Ferry Ivan Balto Suwanto, and Sunarsih . "INCURRED SAMPLE STABILITY OF METFORMIN HYDROCHLORIDE IN PLASMA OF SIX HEALTHY SUBJECTS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 260. http://dx.doi.org/10.22159/ijap.2018.v10s1.58.

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Objective: This study aimed to measure metformin levels and evaluates the incurred stability in plasma of six healthy subjects after administration850 mg metformin hydrochloride tablet using high-performance liquid chromatography.Methods: Samples were collected from six healthy subjects who were administered 850 mg metformin hydrochloride tablet. Blood was collected fromthe subjects at up to 12-time points throughout a 12 h period. Sample stability was analyzed on days 7, 14, and 30. The analysis was conducted usingC-18 columns, a column temperature of 40°C, a mobile phase consisting of aceton

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Santosh Kumar, P., Wuchen a, Liuzhen b, and Dheeraj Shesha Battar. "VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF JANUMET XR (SITAGLIPTIN/METFORMIN HCL EXTENDED-RELEASE FIXED DOSE COMBINATION (FDC) CONTENT IN BULK AND PHARMACEUTICAL DOSAGE FORM." International Journal of Advanced Research 10, no. 07 (2022): 385–98. http://dx.doi.org/10.21474/ijar01/15045.

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A simple, accurate, precise and rapid stability indicating reverse phase High performance chromatography method was used for estimation of Sitagliptin/metformin HCl ER tablets in bulk and fixed-dose combination solid oral dosage form. The proposed analytical method has been validated for specificity, Linearity, Accuracy, Precision and Robustness. The chromatography was achieved in a Avantor, ACE C18 (Length 150 x Diameter 4.6mm Particle size 5Âµm) column with gradient flow. The optimal chromatographic condition consisted of mobile phase pH 3.5 at a flow rate of 1.2 mL/min, with a column temper

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Shaikh, Jalil K., Ajay Babu M, Mazahar Farooqui, and Ummul Khair Asema Syed. "An Innovative Method For Estimation Of Metformin HCl and Acarbose in Pharmaceutical Products and Seperation of Metformin Impurities By RP-HPLC." International Journal of PharmTech Research 13, no. 2 (2020): 71–79. http://dx.doi.org/10.20902/ijptr.2019.130210.

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A Simple, rapid, cost effective, stability indicating RP-HPLC method has been developed for separation of Metformin HCl, its related impurities and Acarbose. Validated the method for simultaneous estimation of Metformin (MF) and Acarbose (ACB) in its novel combination of tablet formulation with Metformin 500 mg and Acarbose 50 mg. Metformin HCl is an orally-administered biguanide, anti-hyperglycemic agent, used in the management of non-insulin dependent diabetes mellitus. Acarbose is an oligosaccharide, used orally for the treatment of type 2 diabetes mellitus. The separation was achieved by u

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Doctor, Ninad, and Yu Yang. "Separation and Analysis of Aspirin and Metformin HCl Using Green Subcritical Water Chromatography." Molecules 23, no. 9 (2018): 2258. http://dx.doi.org/10.3390/molecules23092258.

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Organic solvents are widely used in pharmaceutical and chemical industry for chromatographic separations. In recent years, subcritical water chromatography (SBWC) has shown ability in replacing hazardous organic solvents used in traditional high-performance liquid chromatography (HPLC). In this work, a pain killer—aspirin—and an antidiabetic drug—metformin HCl—were successfully separated on an XBridge C18 column using no organic solvents in the subcritical water chromatography mobile phase. Both traditional HPLC and subcritical water chromatography were used for comparison purposes. SBWC separ

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