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Journal articles on the topic 'Metformin Hydrochloride'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

K, Vijay, and Naruka PS. "Latest Advancements on Gastro Floating Bi-Layer Tablets of Metformin and Pioglitazone for the Treatment of Diabetes Mellitus." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1683–93. https://doi.org/10.25258/ijddt.14.4.76.

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The synergistic mode of action of pioglitazone hydrochloride (PG) and metformin hydrochloride (MH) has great potential for the treatment of type 2 diabetes mellitus. Because of their complementary modes of action, metformin hydrochloride (MH) and pioglitazone hydrochloride (PG) have great potential for the therapy of type 2 diabetes mellitus. Short half-life and the low absorption of metformin hydrochloride in lower gastrointestinal tract might restrict the action towards its expected therapeutic usefulness. This work aimed to create gastro-floating bilayer matrix tablets that would each conta

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K, Vijay, and Naruka PS. "Latest Advancements on Gastro Floating Bi-Layer Tablets of Metformin and Pioglitazone for the Treatment of Diabetes Mellitus." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1683–93. https://doi.org/10.25258/ijddt.14.4.77.

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The synergistic mode of action of pioglitazone hydrochloride (PG) and metformin hydrochloride (MH) has great potential for the treatment of type 2 diabetes mellitus. Because of their complementary modes of action, metformin hydrochloride (MH) and pioglitazone hydrochloride (PG) have great potential for the therapy of type 2 diabetes mellitus. Short half-life and the low absorption of metformin hydrochloride in lower gastrointestinal tract might restrict the action towards its expected therapeutic usefulness. This work aimed to create gastro-floating bilayer matrix tablets that would each conta

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&NA;. "Glucophage (Metformin Hydrochloride)." Gastroenterology Nursing 19, no. 3 (1996): 113–16. http://dx.doi.org/10.1097/00001610-199605000-00008.

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4

Solanki, MS, and PK Goyal. "Simultaneous Estimation of Teneligliptin and Metformin Hydrochloride in Tablet Formulation by UV Spectrophotometric Method." Chemistry Research Journal 6, no. 6 (2021): 160–65. https://doi.org/10.5281/zenodo.12092999.

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<strong>Abstract </strong>Simple, sensitive and accurate UV-spectroscopic methods were developed and validated for simultaneous estimation of Teneligliptin and Metformin Hydrochloride in tablet formulation using simultaneous equation method. Wavelengths which could be utilized for simultaneous analysis of TGN and MET were 245 nm (λ<sub>max</sub> of TGN) and 233 nm (λ<sub>max</sub> of MET) respectively from the overlain spectra. Linearity was found to be satisfactory over the concentration range of 1-30 μg/ml for both the drugs. The mean percentage label claim of Teneligliptin

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Rajagopal, Ponnu lakshmi. "Molecular docking analysis of metformin analogues with GSK-3β". Bioinformation 18, № 3 (2022): 269–72. http://dx.doi.org/10.6026/97320630018269.

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We report the molecular docking analysis of four analogues of metformin [1-Carbamimidoyl-1,2-dimethylguanidine hydrochloride, Metformin hydrochloride, N1,N1-Dimethyl-N5-methylbiguanide hydrochloride, and N1,N1,N5,N5-Tetrakis(methyl-biguanide hydrochloride] with GSK3.

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6

Shilpa, Lakinapally* Ramakrishna Raparla. "DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND METOPROLOL FROM COMBINATION DOSAGE FORMS." Journal of Pharma Research 11, no. 06 (2022): 66–71. https://doi.org/10.5281/zenodo.7472721.

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<strong><em>ABSTRACT</em></strong> <strong>A</strong>n effortless, hasty, unambiguous, robust, exact as well as precise isocratic high performance liquid chromatographic technique has been urbanized in addition to validated for the assessment of simultaneous estimation of Metformin Hydrochloride and Metoprolol Tartrate from the plasma samples. The chromatographic severance was accomplished on Phenomenex kinetex C18 (250mm×4.6mm i.d, 5µm) column by means of a mobile phase mixture containing methanol: buffer of pH 6.8: ACN in the proportion of 47:23:30 respectively at a flow rate of

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7

Borole, T., M. Dewani, S. Gandhi, and M. Damle. "SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND REPAGLINIDE BY HPLC METHOD." INDIAN DRUGS 49, no. 01 (2012): 54–60. http://dx.doi.org/10.53879/id.49.01.p0054.

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A reverse phase high performance liquid chromatographic method is developed for the simultaneous determination of metformin hydrochloride and repaglinide. Chromatography was carried out at ambient temperature and separation of these drugs was achieved on neosphere C18 column (150 x 4.6 mm i.d, 3.5 mcgm) as stationary phase with a mobile phase comprising of methanol: 0.05 M acetate buffer (pH 3.5) in ratio of (80:20 V/V) at flow rate 0.8 mL/min. The detection wavelength for metformin hydrochloride and repaglinide was 242 nm. The retention times for metformin hydrochloride and repaglinide were 1

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Ali, Azzam R., Ibrahim I. Duraidi, Munib M. Saket, and Eyad S. M. Abu-Nameh. "Column High-Performance Liquid Chromatographic Method for the Simultaneous Determination of Rosiglitazone and Metformin in a Pharmaceutical Preparation." Journal of AOAC INTERNATIONAL 92, no. 1 (2009): 119–24. http://dx.doi.org/10.1093/jaoac/92.1.119.

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Abstract An efficient, sensitive, and simple method was developed for the simultaneous determination of rosiglitazone and metformin hydrochloride in a combination tablet dosage form by column high-performance liquid chromatography. The mobile phase used was ammonium dihydrogen phosphate adjusted to pH 5.25 with sodium hydroxide. The limits of detection and quantitation were in the range of 0.51.6 g/mL, respectively, for metformin hydrochloride, and 0.002010.0067 g/mL, respectively, for rosiglitazone. The linearity was studied in the concentration range of 0.120.31 g/mL for rosiglitazone and 30

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Podolsky, I. M., I. M. Vladymyrova, A. V. Volkova, D. V. Lytkin, and О. О. Ryshchenko. "Analysis of the range of metformin hydrochloride medicines for the treatment of type II diabetes mellitus." Social Pharmacy in Health Care 8, no. 2 (2022): 67–73. http://dx.doi.org/10.24959/sphhcj.22.251.

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Aim. To analyze the range of metformin hydrochloride medicines registered at the pharmaceutical market of Ukraine for the treatment of type II diabetes mellitus.Materials and methods. When conducting the analysis the data of the State Register of Medicines of Ukraine, namely, reference resources, in particular the Compendium drug reference book, unified clinical protocols for the treatment of type II diabetes in adults, were used as research materials. In the course of the study, documentary, analytical, mathematical-statistical and logical data generalization methods were used. Graphical and

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Harshada, Vaid* Rachana Kamble Vaishnavi Rahane Suhani Bhagat. "A Review on Anti- Diabetic of Transdermal Patches." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 5125–29. https://doi.org/10.5281/zenodo.15560751.

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The primary goal of this study was to create, develop, and test a transdermal drug delivery system containing Metformin hydrochloride to address the key issues associated with the oral route. Metformin hydrochloride transdermal patches were manufactured utilizing the solvent evaporation process. Different formulation trials were conducted by varying the polymer ratios. The thickness, weight fluctuation, and percentage of transdermal patch compositions were all measured. Moisture content, research, and metformin transdermal patches provide a simple and effective means of regulating blood glucos

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11

Zhang, Rui, Cui Feng, Dandan Luo, et al. "Metformin Hydrochloride Significantly Inhibits Rotavirus Infection in Caco2 Cell Line, Intestinal Organoids, and Mice." Pharmaceuticals 16, no. 9 (2023): 1279. http://dx.doi.org/10.3390/ph16091279.

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Rotavirus is one of the main pathogens that causes severe diarrhea in children under the age of 5, primarily infecting the enterocytes of the small intestine. Currently, there are no specific drugs available for oral rehydration and antiviral therapy targeting rotavirus. However, metformin hydrochloride, a drug known for its antiviral properties, shows promise as it accumulates in the small intestine and modulates the intestinal microbiota. Therefore, we formulated a hypothesis that metformin hydrochloride could inhibit rotavirus replication in the intestine. To validate the anti-rotavirus eff

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Kassahun, H., K. Asres, and A. Ashenef. "In vitro quality evaluation of metformin hydrochloride tablets marketed in Addis Ababa." Bangladesh Journal of Scientific and Industrial Research 54, no. 2 (2019): 169–76. http://dx.doi.org/10.3329/bjsir.v54i2.41674.

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In this study, an attempt was made to assess quality as well as pharmaceutical equivalence of six brands of metformin hydrochloride tablets marketed in Addis Ababa using in vitro methods. Friability, disintegration, dissolution and assay for the content of active ingredients were evaluated using the methods described in the United States pharmacopeia (2007). All the brands of metformin hydrochloride tablets complied with the official specification for hardness, friability, disintegration and assay. Five brands of metformin hydrochloride complied with the USP dissolution tolerance limits but Me

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13

Jing, Dong Dong, Yu Liu, Ruo Yu Liu, Hua Fan, Guo Feng Li, and Long Quan Shao. "Absorption Enhancing Effect of Sodium Dodecyl Sulfate on Metformin Hydrochloride in Rat Colon." Key Engineering Materials 544 (March 2013): 426–30. http://dx.doi.org/10.4028/www.scientific.net/kem.544.426.

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The aim of this study was to observe the absorption enhancing effect of sodium dodecyl sulfate on metformin hydrochloride in colon of rat. Using in vivo intestinal loop model in rat while the ileum was took as blank group and colon as the experiment groups with different concentration of sodium dodecyl sulfate (1%, 2%, 4%). The colon/ileum ratio of the absorption rate constant of metformin hydrochloride was evaluated through calculating the residual dose of circulating solution in presupposition time points. Intergroup absorption rate constant and the rising percent of the absorption rate cons

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14

Bagadane, Snehal Bapusaheb, and Prerana B. Jadhav. "Development and validation of RP-HPLC method for simultaneous estimation of metformin hydrochloride and glipizide in bulk and pharmaceutical dosage form." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 146–55. http://dx.doi.org/10.22270/jddt.v9i3-s.2813.

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A simple, accurate, economical and precise reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for simultaneous estimation of Metformin hydrochloride and Glipizide in bulk and pharmaceutical dosage form. The separation of Metformin hydrochloride and Glipizide was achieved by using Cosmosil C 18 (250 mm × 4.6 ID, particle size-5 micron) column as stationary phase with the mobile phase comprising of methanol and water (60:40 ,pH 3 adjusted with ortho-phosphoric acid) in an isocratic mode and flow rate of 0.8 ml/min with UV detection at 226 nm. The retention

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15

Wagstaff, Antona J., and David P. Figgitt. "Extended-Release Metformin Hydrochloride." Treatments in Endocrinology 3, no. 5 (2004): 327–32. http://dx.doi.org/10.2165/00024677-200403050-00008.

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16

Hariharan, M., S. S. Rajan, and R. Srinivasan. "Structure of metformin hydrochloride." Acta Crystallographica Section C Crystal Structure Communications 45, no. 6 (1989): 911–13. http://dx.doi.org/10.1107/s0108270188014246.

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17

Tanwir, Ahmad, Rahat Jahan, Mohiuddin Abdul Quadir, Mohammad A. Kaisar, and Md Khalid Hossain. "Spectroscopic Studies of the Interaction between Metformin Hydrochloride and Bovine Serum Albumin." Dhaka University Journal of Pharmaceutical Sciences 11, no. 1 (2012): 45–49. http://dx.doi.org/10.3329/dujps.v11i1.12486.

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The affinity of a drug to serum albumin has influence on the pharmacokinetics of a drug. In the present study, the mutual interaction of metformin hydrochloride (MET) with bovine serum albumin (BSA) was investigated using fluorescence spectroscopy under different conditions. It was observed that the fluorescence quenching of BSA by metformin hydrochloride is a result of the formation of metformin hydrochloride- BSA complex with probable involvement of tryptophan residue. Fluorescence quenching constants were determined using the Stern- Volmer equation and Vant Hoff equation to provide a measu

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18

S., Gurung* C. Gurung B. Pandit. "Review on Different Analytical Methods for The Estimation of Metformin Hydrochloride and Lisinopril." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1007–16. https://doi.org/10.5281/zenodo.15181782.

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The antihyperglycemic drug metformin hydrochloride is a biguanide. It works by lowering the liver's glucose synthesis and raising the insulin sensitivity of bodily tissues. Lisinopril is an antihypertensive drug that is used to treat excessive blood pressure, heart failure, and heart attacks. Metformin hydrochloride and lisinopril have been determined using a variety of analytical approaches. Chromatographic and UV spectrophotometric methods are examples of these methods. The uses of these approaches for the determination of metformin hydrochloride and lisinopril in pharmaceutical formulations

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19

Barot, Bhavesh, Punit Parejiya, Tushar Patel, Rajesh Parikh, and Mukesh Gohel. "Development of directly compressible metformin hydrochloride by the spray-drying technique." Acta Pharmaceutica 60, no. 2 (2010): 165–75. http://dx.doi.org/10.2478/v10007-010-0016-9.

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Development of directly compressible metformin hydrochloride by the spray-drying technique Metformin hydrochloride exhibits poor compressibility during compaction, often resulting in weak and unacceptable tablets with a high tendency to cap. The purpose of this study was to develop directly compressible metformin hydrochloride by the spray-drying technique in the presence of polymer. Metformin hydrochloride was dissolved in solutions containing a polymer, namely polyvinylpyrrolidone (PVP K30), in various concentrations ranging from 0-3% (m/V). These solutions were employed for spray-drying. Sp

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20

Kakade, Vrushali B., G. A. Lobhe, Snehal G. Gandhat, S. M. ,. Dhobale, and Salim G. Patel. "Estimation of Metformin Hydrochloride in Bulk and Formulation by UV - Spectroscopic Area Under Curve Method." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 163–67. http://dx.doi.org/10.22270/jddt.v9i3.2632.

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The current work is carried out for estimation of Metformin Hydrochloride by using area under curve (AUC) method using UV-visible spectrophotometer. For this purpose the wavelength range 221-241 nm was selected. Distilled water was used as a solvent throughout the work. Linearity was observed in concentration range 5-25 µg/ml (R2= 0.994) for the method. The present method was found to be simple and linear which can be used for routine quality control analysis for spectrophotometric estimation of Metformin hydrochloride in bulk. Keywords: Metformin Hydrochloride, Area under curve, Antidiabetic,

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21

Harahap, Yahdiana, Citra Dara Malia, and Sunarsih . "PHARMACOKINETIC PROFILE OF METFORMIN HYDROCHLORIDE IN DRIED BLOOD SPOT OF HEALTHY SUBJECTS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY–PHOTODIODE ARRAY." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 354. http://dx.doi.org/10.22159/ijap.2018.v10s1.78.

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Objective: This study aimed to analyze the metformin hydrochloride in dried blood spot (DBS) sample and evaluate a pharmacokinetic profile in sixhealthy subjects who administered 850-mg metformin hydrochloride in tablet using high-performance liquid chromatography–photodiode array(HPLC–PDA).Methods: Metformin analysis was performed on data of six healthy subjects who administered 850 mg of metformin hydrochloride as tablets. Bloodsamples were taken at 12-time points at intervals of up to 12 h, and data were analyzed using HPLC–PDA.Results: A linear calibration curve was obtained in the range o

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22

Prameela, Rani A., S. Madhavi, Rao B. Tirumaleswara, and Sudheer Reddy CH. "STABILITY INDICATING UPLC METHOD FOR ESTIMATION OF METFORMIN HYDROCHLORIDE AND NATEGLINIDE SIMULTANEOUSLY IN THE PRESENCE OF STRESS DEGRADATION PRODUCTS." INDIAN DRUGS 57, no. 05 (2020): 56–64. http://dx.doi.org/10.53879/id.57.05.11332.

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A novel Ultra Performance Liquid Chromatography (UPLC) method was developed and validated for the simultaneous determination of antidiabetic drugs metformin hydrochloride and nateglinide. The method was developed using a Waters ACQUITY UPLC SB C18 (100 × 2.1 mm, 1.8 μm) column. The mobile phase consisting of 0.01 % potassium dihydrogen phosphate buffer (pH 5.8): acetonitrile (50: 50 V/V) was used throughout the analysis. The flow rate was 0.3 mL/min, the injection volume was 1.0 μL, column temperature was 30 0C, run time 3 min and detection was carried at 238 nm using a TUV detector. The reten

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SushamaAmbadekar1, &. Sameer Keni*2. "RAPID HPLC METHOD FOR IMPURITY PROFILE OF METFORMIN HYDROCHLORIDE IN PRESENCE OFITS COMBINATION DRUGS." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES 5, no. 11 (2018): 150–60. https://doi.org/10.5281/zenodo.1493916.

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A fast and selective method using HPLC was developed for determination of impurity profile of Metformin hydrochloride in the presence of its usual combination of drugs. Antidiabetic combination of drugs like Glipizide, Gliclazide, Glibenclamide, Glimepiride along with Metformin Hydrochloride are available for treatment of diabetic patients in India. A single method of analysis for Impurity profile of Metformin along with each of the four drug combination with Metformin was developed. The method was validated and proved to be specific, precise and robust. Area response was found to be linear in

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24

Salem, Hesham. "Determination of Metformin Hydrochloride and Glyburide in an Antihyperglycemic Binary Mixture Using High-Performance Liquid Chromatographic-UV and Spectrometric Methods." Journal of AOAC INTERNATIONAL 93, no. 1 (2010): 133–40. http://dx.doi.org/10.1093/jaoac/93.1.133.

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Abstract Three methods were developed for simultaneous determination of metformin hydrochloride and glyburide in an antihyperglycemic binary mixture without previous separation. In the first method, a reversed-phase HPLC column with acetonitrilewater (60 + 40, v/v) mobile phase at 0.9 mL/min flow rate was used to separate both compounds, with UV detection at 254 nm. Linearity was obtained in the concentration range of 0.060.24 µg/mL for glyburide and 1.56.0 µg/mL for metformin hydrochloride. The second method depended on first- and second-derivative UV spectrometry with zero-crossing measureme

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25

Ali Almaqtari, Maher, Najat Ahmed Al-Odaini, Fares Abdullah Alarbagi, and Hussein Al-Maydama. "Development and validation of a new spectrophotometric method for simultaneous determination of sitagliptin and metformin hydrochloride in tablet pharmaceutical dosage forms using chemometrics technique in comparison with HPLC." Ecletica Quimica 48, no. 1 (2023): 72–94. http://dx.doi.org/10.26850/1678-4618eqj.v48.1.2023.p72-94.

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A new, quick, easy, affordable and eco-friendly simultaneous spectrophotometric method for determining a combined sitagliptin and metformin hydrochloride in pharmaceutical formulations was developed and validated using two chemometrics technique. These two methods are the partial least square (PLS) and principal component regression (PCR). They do not need to do a sample preparation or separation before analysis. Various drug concentrations and instrumental spectra of 25 mixed solutions of a combination of sitagliptin and metformin hydrochloride were used for model construction in the range of

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26

Muravleva, Oksana. "Therapy of II Type Diabetes Mellitus: Efficiency is Proved by Time." Family Medicine, no. 5 (December 30, 2016): 13–14. http://dx.doi.org/10.30841/2307-5112.5.2016.248620.

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The article deals with the topical issue of endocrinology 1 diabetes mellitus (DM), which is spread with catastrophic speed and becoming a real epidemic of XXI century. Metformin hydrochloride for many years has proved its effectiveness in the therapy of II type diabetes mellitus. Therefore, Metformin hydrochloride is the main treatment for diabetes II type.

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Muravliova, Oksana. "Therapy of II Type Diabetes Mellitus: Efficiency is Proved by Time." Family Medicine, no. 5 (November 30, 2016): 13–14. https://doi.org/10.30841/2307-5112.5.2016.248620.

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The article deals with the topical issue of endocrinology – diabetes mellitus (DM), which is spread with catastrophic speed and becoming a real epidemic of XXI century. Metformin hydrochloride for many years has proved its effectiveness in the therapy of II type diabetes mellitus. Therefore, Metformin hydrochloride is the main treatment for diabetes II type.

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Klepser, Teresa B., and Michael W. Kelly. "Metformin hydrochloride: An antihyperglycemic agent." American Journal of Health-System Pharmacy 54, no. 8 (1997): 893–903. http://dx.doi.org/10.1093/ajhp/54.8.893.

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29

Havele, Shweta, and Sunil Dhaneshwar. "Determination of glibenclamide, metformin hydrochloride and rosiglitazone maleate by reversed phase liquid chromatographic technique in tablet dosage form." Chemical Industry and Chemical Engineering Quarterly 20, no. 1 (2014): 39–47. http://dx.doi.org/10.2298/ciceq120607101h.

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A simple, precise and accurate high performance liquid chromatography (HPLC) method was developed for the simultaneous estimation of metformin hydrochloride, rosiglitazone maleate, glibenclamide present in multicomponent dosage forms. Chromatography was performed on a 25 cm ? 4.6 mm i.d., 5-?m particle, C18 column with 78:22 (v/v) methanol: 20 mM potassium dihydrogen phosphate buffer as mobile phase at a flow rate of 1.0 ml/min and UV detection at 238 nm for metformin hydrochloride, rosiglitazone maleate, and glibenclamide. The total elution time was shorter than 9 min. This method was found t

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Sultanova Adolat Aminboyevna and Muxamedova Dilyora Shuxrat qizi. "SIOFOR DRUG ANALYSIS FOR THE FORENSIC CHEMISTRY PRACTICE." Journal of Pharmaceutical Negative Results 13, no. 4 (2022): 749–55. http://dx.doi.org/10.47750/pnr.2022.13.04.100.

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Siofor (metformin hydrochloride) is widely used to maintain weight in the second type of diabetes and as a complex treatment of obesity, as well as a slimming agent in biologically active supplements under various names. The presence of metformin hydrochloride with the strong effect of reducing sibutramine in Reduksin Forte capsules, taking it together with other disproportionate drugs causes an increase in cases of acute poisoning. In such cases, in order to provide quick medical assistance to patients, in order to obtain quick and accurate results in forensic chemistry practice, specific che

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Bhanu Teja Reddy Thumkuntla and Manjunath Sooganna Yalagatti. "RP-HPLC method for estimation of miglitol and metformin hydrochloride in pharmaceutical formulation." GSC Biological and Pharmaceutical Sciences 23, no. 3 (2023): 138–46. http://dx.doi.org/10.30574/gscbps.2023.23.3.0219.

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A simple, rapid and sensitive RP-HPLC method was developed for the quantitative determination of metformin hydrochloride and miglitol in combined tablet dosage form. The chromatographic analysis was carried out on Phenomenex Gemini C18 (250 x 4.6 mm, 5 μm) with mobile phase containing methanol: TEA buffer (50:50 v/v). The flow rate of mobile phase was 1.0 mL/min and effluents were monitored at 272 nm. The retention times of miglitol and metformin hydrochloride were 2.121 min and 3.643 min, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specifici

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Kaur, Simran, and Sunil Gupta. "Forensic evaluation of solid dosage form using a thermoanalytical method." Pharmaspire 14, no. 03 (2022): 109–15. http://dx.doi.org/10.56933/pharmaspire.2022.14214.

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In the present study, a generic dosage form of metformin hydrochloride was developed using deformulation of a marketed product. The excipients used in the marketed product were identified using thermospectral method such as differential scanning calorimetry (DSC). The marketed formulation contained metformin hydrochloride 850 mg. The ingredients present in the marketed dosage form after performing thermal analysis were identified as metformin hydrochloride, sodium carboxymethyl cellulose, microcrystalline cellulose, hydroxypropyl methyl cellulose, and magnesium stearate. DSC analyses of the in

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Bhanu, Teja Reddy Thumkuntla, and Sooganna Yalagatti Manjunath. "RP-HPLC method for estimation of miglitol and metformin hydrochloride in pharmaceutical formulation." GSC Biological and Pharmaceutical Sciences 23, no. 3 (2023): 138–46. https://doi.org/10.5281/zenodo.8260363.

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A simple, rapid and sensitive RP-HPLC method was developed for the quantitative determination of metformin hydrochloride and miglitol in combined tablet dosage form. The chromatographic analysis was carried out on Phenomenex Gemini C18 (250 x 4.6 mm, 5 μm) with mobile phase containing methanol: TEA buffer (50:50 v/v). The flow rate of mobile phase was 1.0 mL/min and effluents were monitored at 272 nm. The retention times of miglitol and metformin hydrochloride were 2.121 min and 3.643 min, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specif

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34

Roselet,, S. Lizy, and Dr J. Premakumari. "STUDIES ON METFORMIN HYDROCHLORIDE AND ALPHA-CYCLODEXTRIN INCLUSION COMPLEXES." Green Chemistry & Technology Letters 1, no. 01 (2015): 48–53. http://dx.doi.org/10.18510/gctl.2015.117.

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Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type-2 diabetes. Inclusion complexes were prepared between Metformin hydrochloride and alpha- cyclodextrin in solid and solution state. Inclusion complexes were characterised using UV-VIS, Fluorescence and FTIR Spectroscopic Studies. Phase solubility studies were carried out which determined the 1:1 stoichiometry for the formation of inclusion complexes.

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Nerdy, Nerdy, Linda Margata, Dian Ika Perbina Meliala, et al. "Application of Fourier Transform Infrared Spectrophotometry Method for Analysis of Metformin Hydrochloride in Marketed Tablet Dosage Form." Jurnal Kimia Valensi 7, no. 2 (2021): 168–77. http://dx.doi.org/10.15408/jkv.v7i2.22158.

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The first line drug given for monotherapy for diabetes mellitus type 2 is metformin hydrochloride, which is a biguanide antihyperglycemic drug. The aim of this research was to develop, validate, and apply the Fourier Transform Infrared spectrophotometry method to identify and determine metformin hydrochloride in marketed tablet dosage form. This research included preparation of standard, analysis of samples, and validation of method. The specific wavenumber obtained for qualitative analysis was 1645.68 cm–1 and 1574.8 cm–1. The specific area obtained for quantitative analysis with a single bas

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Valte, Yugesh Balkrishana, Haridas Ajinath Sangale, Harjot Singh Kathuria, Swati Gokul Talele, and Anil Govindrao Jadhav. "Formulation and evaluation of gastro retentive extended release formulation of metformin hydrochloride." GSC Advanced Research and Reviews 2, no. 2 (2020): 008–17. https://doi.org/10.5281/zenodo.4318221.

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The present research think about was to deliver definition and assessment of gastro retentive extended release formulation of metformin hydrochloride. The programming interface metformin hydrochloride and polymer and all excipients were weighed precisely, blended well and by utilizing rotatory pressure machine.(F.P. hardware,accura little press multistation tooling machine) and by utilizing 9mm punch of case shape which has length of 2cm and inside breadth of 9 mm. Utilizing this punch tablets were arranged and continues for promote study. Metformin hydrochloride is hostile to hyperglycaemic s

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Shaikh, Shoheb S., and Nachiket S. Dighe. "Simultaneous estimation of pioglitazone, glimepiride & metformin hydrochloride in bulk & tablet dosage form by UV, RP-HPLC method." International Journal of Pharmaceutical Chemistry and Analysis 8, no. 3 (2021): 91–99. http://dx.doi.org/10.18231/j.ijpca.2021.019.

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A stability-indicating UV spectroscopic and high-performance liquid chromatography (RP-HPLC) method is developed for the quantification ofPioglitazone, Glimepiride & Metformin Hydrochloride drug substances. UV spectroscopic method was developed and validated, the wavelength selected for simultaneous estimation were 226nm for pioglitazone, 229nm for glimepiride and 232nm for metformin hydrochloride. The isosbestic point found for the analysis was 229nm. Selected mobile phase was a combination of methanol and water with a ratio of 70% Methanol and 30 % HPLC water with the flow rate of 0.85ml

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Szekalska, Marta, Magdalena Wróblewska, Katarzyna Sosnowska, and Katarzyna Winnicka. "Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying." International Journal of Polymer Science 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/8635408.

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Alginate microspheres with metformin hydrochloride were prepared by the spray drying method in order to improve residence time of drug in the stomach. Nine formulations (F1–F9) with various drug : polymer ratio (1 : 2, 1 : 1, and 2 : 1) and different sodium alginate concentration (1%, 2%, and 3%) were evaluated for size, morphology, drug loading, Zeta potential, and swelling degree.In vitrodrug release, mathematical release profile, and physical state of microspheres were also evaluated. Optimal formulation characterized by the highest drug loading was formulation F6 (drug : polymer ratio 2 :

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PUTRA, I. M. W. A., I. G. A. W. KUSUMAWATI, and A. W. PERMADI. "Modification of Clinoptilolite with Benzalkonium Chloride as a Carrier of Metformin Hydrochloride." Asian Journal of Chemistry 31, no. 6 (2019): 1275–78. http://dx.doi.org/10.14233/ajchem.2019.21887.

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Clinoptilolites have a limitation in the adsorption of drug molecules due to their fixed pore structure. In this study, we modified the clinoptilolite with benzalkonium chloride. The modification was carried out by stirring 1 g of NaCl activated clinoptilolite with 100 mL of benzalkonium chloride solution with a concentration of 0.5, 1, 5, 10 and 15 % at room temperature for 24 h. After filtration and drying process, benzalkonium chloride modified clinoptilolite was stirred with 100 mL of 300 mg/L metformin hydrochloride solution at room temperature for 24 h. The result of sample characterizat

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Chowdary, Y. Ankamma, Ramakrishna Raparla, and Muramshetty Madhuri. "Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride." Journal of Pharmaceutics 2014 (May 12, 2014): 1–14. http://dx.doi.org/10.1155/2014/848243.

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In the treatment of type 2 diabetes mellitus a continuous therapy is required which is a more complex one. As in these patients there may be a defect in both insulin secretion and insulin action exists. Hence, the treatment depends on the pathophysiology and the disease state. In the present study, multilayered tablets of pioglitazone hydrochloride 15 mg and metformin hydrochloride 500 mg were prepared in an attempt for combination therapy for the treatment of type 2 diabetes mellitus. Pioglitazone HCl was formulated as immediate release layer to show immediate action by direct compression met

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Dharmamoorthy, G. "DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE IN PHARMACEUTICAL DOSAGE FORM." YMER Digital 21, no. 08 (2022): 612–26. http://dx.doi.org/10.37896/ymer21.08/52.

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A simple, specific, accurate and precise High Performance Thin Layer Chromatography (HPTLC) method was developed which can separate and quantitatively estimate formulation of Metformin Hydrochloride and Pioglitazone The chromatographic separation for Metformin Hydrochloride and Pioglitazone in HPTLC method separation was achieved with the mobile phase consisting of Toluene: Methanol: Triethylamine (6: 4: 0.1 % v/v/v/v). The detection of spot was carried out at 230 nm and the Rf values Metformin Hydrochloride and Pioglitazone were found to be 0.25±0.03 and 0.47±0.04.. Ths method was validated a

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CS, Kagarana, Patel KN, and Patel AB. "Forced Degradation Method Development and Validation for Simultaneous Determination of Vildagliptin, Metformin Hydrochloride and Remogliflozin Etabonate in Bulk and its Formulation by RP-HPLC." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 119–23. http://dx.doi.org/10.25258/ijpqa.15.1.19.

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A simple and efficient stability-indicating method has been developed and validated for the simultaneous estimation of vildagliptin, metformin hydrochloride and remogliflozin etabonate in bulk and was applied on marketed formulations. KH2PO4 buffer (10 mM): Acetonitrile (70:30% v/v) at pH 5 was used as a mobile phase. Detection of drug peaks was at 215 nm by UV detector. The method was found to be linear in the concentration range of 2.5 to 7.5, 25 to 75 and 5 to 15 μg/mL for vildagliptin, metformin hydrochloride and remogliflozin etabonate, respectively. The limit of detection (LoD) and quant

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Harahap, Yahdiana, Ferry Ivan Balto Suwanto, and Sunarsih . "INCURRED SAMPLE STABILITY OF METFORMIN HYDROCHLORIDE IN PLASMA OF SIX HEALTHY SUBJECTS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 260. http://dx.doi.org/10.22159/ijap.2018.v10s1.58.

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Objective: This study aimed to measure metformin levels and evaluates the incurred stability in plasma of six healthy subjects after administration850 mg metformin hydrochloride tablet using high-performance liquid chromatography.Methods: Samples were collected from six healthy subjects who were administered 850 mg metformin hydrochloride tablet. Blood was collected fromthe subjects at up to 12-time points throughout a 12 h period. Sample stability was analyzed on days 7, 14, and 30. The analysis was conducted usingC-18 columns, a column temperature of 40°C, a mobile phase consisting of aceton

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Bookya, Padmaja, Ramakrishna Raparla, Ramakrishna Raparla, et al. "FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE SUSTAINED-RELEASE ORAL MATRIX TABLETS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 342. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.21211.

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Objective: The aim of this investigation was to develop and optimize metformin hydrochloride matrix tablets for sustained release application. The sustained release matrix tablet of metformin hydrochloride was prepared by wet granulation technique using chitosan, xanthan gum, and hydroxypropyl methylcellulose at varying concentrations.Material and Methods: Extended release of metformin hydrochloride matrix tablets was prepared by wet granulation method. The influence of varying the polymer ratios was evaluated. The excipients used in this study did not alter physicochemical properties of the d

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Patel, Aesha A., Manisha C. Kotadiya, and Bhakti Shah. "Development and Analytical Method Validation for Simultaneous Estimation of Evoglptin Tartrate and Metformin Hydrochloride in Combine Dosage Form." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 13, no. 04 (2022): 504–9. http://dx.doi.org/10.25258/ijpqa.13.4.25.

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Metformin hydrochloride is a diabetes medication that is used orally. Evogliptin tartrate is a dipeptidyl peptidase-4 (DPP-4) inhibitor which has been authorized as a new and powerful treatment in the process of reducing glucagon-like peptide 1 (GLP-1) deficiency while increasing insulin production and decreasing glucagon levels. The current study created a simple, highly exact, and rapid reverse phase high-performance liquid chromatography (RP-HPLC) approach for the simultaneous measurement of metformin hydrochloride and evogliptin tartrate in their combined dose form. High-performance liquid

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Rebitski, Ediana P., Pilar Aranda, Margarita Darder, Raffaele Carraro, and Eduardo Ruiz-Hitzky. "Intercalation of metformin into montmorillonite." Dalton Transactions 47, no. 9 (2018): 3185–92. http://dx.doi.org/10.1039/c7dt04197g.

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Henry, Wesley D. "Metformin Hydrochloride in Patients Undergoing Myelography." American Journal of Roentgenology 178, no. 5 (2002): 1289. http://dx.doi.org/10.2214/ajr.178.5.1781289.

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Bell, David. "Single-Composition Extended-Release Metformin Hydrochloride." Treatments in Endocrinology 3, no. 5 (2004): 333–34. http://dx.doi.org/10.2165/00024677-200403050-00009.

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Fonseca, Vivian. "Single-Composition Extended-Release Metformin Hydrochloride." Treatments in Endocrinology 3, no. 5 (2004): 333–34. http://dx.doi.org/10.2165/00024677-200403050-00010.

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Garza-Ocañas, Lourdes, Jorge González-Canudas, Eduardo Tamez-de la O, et al. "Comparative Bioavailability of Metformin Hydrochloride Oral Solution Versus Metformin Hydrochloride Tablets in Fasting Mexican Healthy Volunteers." Advances in Therapy 36, no. 2 (2018): 407–15. http://dx.doi.org/10.1007/s12325-018-0853-3.

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