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Journal articles on the topic 'Methanol And Validation'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kolobaric, Adam, Rebecca Orrell-Trigg, Seth Orloff, Vanessa Fraser, James Chapman, and Daniel Cozzolino. "The Use of a Droplet Collar Accessory Attached to a Portable near Infrared Instrument to Identify Methanol Contamination in Whisky." Sensors 23, no. 21 (2023): 8969. http://dx.doi.org/10.3390/s23218969.

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The aim of this study was to evaluate the ability of a droplet collar accessory attached to a portable near-infrared (NIR) instrument to characterize the artificial contamination of methanol in commercial whisky samples. Unadulterated samples (n = 12) were purchased from local bottle shops where adulterated samples were created by adding methanol (99% pure methanol) at six levels (0.5%, 1%, 2%, 3%, 4% and 5% v/v) to the commercial whisky samples (controls). Samples were analyzed using a drop collar accessory attached to a MicroNIR Onsite instrument (900–1650 nm). Partial least squares (PLS) cr

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2

Tuslinah, Lilis, Laras Rizkia Widyastuti, and Mochamad Fathurohman. "Validation of the Use of Anthocyanin as Indicators for Acid-Base Titration." Jurnal Kimia Sains dan Aplikasi 28, no. 2 (2025): 53–61. https://doi.org/10.14710/jksa.28.2.53-61.

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Rambutan peel (Nephelium lappaceum L.) contains secondary metabolites, particularly flavonoids, including anthocyanins. Anthocyanins exhibit color changes in response to variations in pH, making them potential candidates for use as acid-base indicators. This study aims to validate using methanol fraction powder derived from rambutan peel as an acid-base titration indicator by evaluating method validation parameters such as precision, accuracy, and linearity. The fractionation process was conducted using liquid-liquid extraction with n-hexane, water, and methanol as solvents, followed by freeze

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3

Collazo, J., J. Porteiro, D. Patiño, J. L. Miguez, E. Granada, and J. Moran. "Simulation and experimental validation of a methanol burner." Fuel 88, no. 2 (2009): 326–34. http://dx.doi.org/10.1016/j.fuel.2008.09.003.

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4

Snehadeepa, Ghosh, Dhua* Manabendra, Chatterjee Srijita, and Sarathi Panda Partha. "DEVELOPMENT AND VALIDATION OF ASSAY METHOD FOR ESTIMATION OF ATORVASTATIN." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 942–50. https://doi.org/10.5281/zenodo.15302992.

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UV-Vis spectrophotometric method is a well-established technique to assay bulk drug as well as formulation owing to its simplicity as well as time efficiency. This work is an aim to develop simple and sensitive method to assay atorvastatin calcium both in bulk as well as in tablet by UV spectrophotometric method. New UV- spectrophotometric assay was developed using phosphate buffer and methanol which is used as cosolvent. In this method the drug was dissolved in methanol and diluted with methanol and phosphate buffer (pH 7.2). Method validation parameters like linearity, accuracy, precision, r

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5

Akukwu, Darlington Cyprain, Darlington Nnamdi Onyejike, Chiamaka Mercy Iwuala, et al. "Embalming of Early Decomposing Strangled Homicides in Anambra State, Nigeria: A Validation Study." Scholars International Journal of Anatomy and Physiology 5, no. 5 (2022): 83–92. http://dx.doi.org/10.36348/sijap.2022.v05i05.001.

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Formalin is one of the commonest embalming fluid used in modern embalming. Methanol can also be mixed with formalin in order to prevent the precipitation of formaldehyde to paraformaldehyde. Methanol is also a good preservative. Strangled bodies remain one of common homicides received at funeral homes in Anambra state, Nigeria. Therefore, the objectives of this study are to observe the early decomposition activities in Anambra state; use an embalming mixture containing formalin, methanol and water to arrest it; and document the techniques used to achieve it. Therefore, four infant pigs were us

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6

Muna, E. D. M., C. H. B. Bizarri, J. R. M. Maciel, G. P. da Rocha, and I. O. de Araújo. "Method validation for methanol quantification present in working places." Journal of Physics: Conference Series 575 (January 6, 2015): 012031. http://dx.doi.org/10.1088/1742-6596/575/1/012031.

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7

Skodje, Rex T., Alison S. Tomlin, Stephen J. Klippenstein, Lawrence B. Harding, and Michael J. Davis. "Theoretical Validation of Chemical Kinetic Mechanisms: Combustion of Methanol." Journal of Physical Chemistry A 114, no. 32 (2010): 8286–301. http://dx.doi.org/10.1021/jp1047002.

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8

Lacerda de Oliveira Campos, Bruno, Karla Herrera Delgado, Stefan Wild, Felix Studt, Stephan Pitter, and Jörg Sauer. "Surface reaction kinetics of the methanol synthesis and the water gas shift reaction on Cu/ZnO/Al2O3." Reaction Chemistry & Engineering 6, no. 5 (2021): 868–87. http://dx.doi.org/10.1039/d1re00040c.

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9

Jiamin, Sun, Yang Chengcheng, Zhang Lijing, and Tao Gang. "Aspen plus Simulation and Analysis of Methanol Synthesis Process." E3S Web of Conferences 385 (2023): 04009. http://dx.doi.org/10.1051/e3sconf/202338504009.

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According to the actual situation of methanol production process, Aspen Plus software is used to build the methanol synthesis process flow model. The main and side reaction system is built in the model, which is realized by connecting the main and side reactors in series and setting the conversion rate of side reaction. Considering the model validation and process integrity, the methanol rectification system is connected in series on the basis of the methanol synthesis model, and the steady state simulation of the whole process is carried out. The methanol purity simulated is 99.74%, which sho

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10

Ogale, Shital Ashokrao* Madhav A. Shetkar. "Method Development And Validation Of Asciminib By RPHPLC." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 278–86. https://doi.org/10.5281/zenodo.11486334.

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Another methodology was set up for synchronous estimation of a Asciminib by RP-HPLC system. The chromatographic conditions were viably created for the unit of Asciminib by using Inertsil - ODS C18(250 x 4.6 mm, 5µ), stream is 1.0 ml/min, convenient stage extent was Methanol: Acetonitrile (60:40), recognizable proof wave length was 274nm.

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11

Lachance, Philippe, Fabrice Mac-Way, Simon Desmeules, Sacha A. De Serres, Pierre Douville, and Mohsen Agharazii. "FP475PREDICTION AND VALIDATION OF HEMODIALYSIS DURATION IN INTENTIONAL METHANOL POISONING." Nephrology Dialysis Transplantation 30, suppl_3 (2015): iii230. http://dx.doi.org/10.1093/ndt/gfv179.04.

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12

Eccarius, Steffen, Brenda Lee Garcia, Christopher Hebling, and John W. Weidner. "Experimental validation of a methanol crossover model in DMFC applications." Journal of Power Sources 179, no. 2 (2008): 723–33. http://dx.doi.org/10.1016/j.jpowsour.2007.11.102.

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13

Lachance, Philippe, Fabrice Mac-Way, Simon Desmeules, et al. "Prediction and validation of hemodialysis duration in acute methanol poisoning." Kidney International 88, no. 5 (2015): 1170–77. http://dx.doi.org/10.1038/ki.2015.232.

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14

CHOI, K., H. KIM, J. DORR, H. YOON, and P. ERICKSON. "Equilibrium model validation through the experiments of methanol autothermal reformation." International Journal of Hydrogen Energy 33, no. 23 (2008): 7039–47. http://dx.doi.org/10.1016/j.ijhydene.2008.09.015.

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15

Rajat, Garg Anuj Garg. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR TACROLIMUS IN BULK AND MARKETED GEL." Turkish Journal of Physiotherapy and Rehabilitation 32, no. 3 (2021): 41116–72. https://doi.org/10.5281/zenodo.6973281.

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Tacrolimus (FK506) is a calcineurin inhibitor and immunosuppressant. It has the chemical formula C<sub>44</sub>H<sub>69</sub>NO<sub>12</sub> and is a 23-membered macrolide lactone. (Figure 1) that was discovered for the first time in 1987 in <em>Streptomyces tsukubaensis</em>. The US Food and Drug Administration (USFDA) originally approved it for liver transplantation in 1994.

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Rajat, Garg Anuj Garg. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR TACROLIMUS IN BULK AND MARKETED GEL." Turkish Journal of Physiotherapy and Rehabilitation 32, no. 3 (2021): 41116–72. https://doi.org/10.5281/zenodo.6973341.

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17

Yefimov, Stanislav V. "Analysis of Methylcobalamin and Hydroxocobalamin by HPLC/MS. Method Validation." Scholars Academic Journal of Pharmacy 12, no. 03 (2023): 67–73. http://dx.doi.org/10.36347/sajp.2023.v12i03.003.

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Previously, we found that methylcobalamin spontaneously converts to hydroxocobalamin at room temperature in aqueous and methanol solutions protected from light. The kinetics and rate constants were determined. This work is devoted to the validation of the method for the quantitative determination of methylcobalamin and hydroxocobalamin in pharmaceutical preparations.

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18

Waluyo, Budi, and Bagiyo Condro Purnomo. "Exhaust Gas Emissions of Homogeneous Gasoline-Methanol-(Ethanol) Blends." Automotive Experiences 5, no. 2 (2022): 173–81. http://dx.doi.org/10.31603/ae.6599.

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In recent years, one of the most logical efforts made to reduce the dependence on fossil energy sources is the use of a gasoline-methanol fuel blend. However, the problem in using a gasoline-methanol blend as fuel is that the methanol will eventually separate itself from the gasoline unless they are properly blended together, this is because methanol has a polar hydroxyl group called monohydric that binds water vapor together, causing the mixture to separate. Previous research showed that adding a small amount of ethanol to the gasoline-methanol blend makes it a homogeneous blend. Therefore, t

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19

Bhavya, Sri N. V. *. and Nallakumar Ponnu Swamy. "BIOANALYTICAL METHOD DEVELOPMENT, VALIDATION AND QUANTIFICATION OF BOSENTAN BY HIGHPERFORMANCE LIQUID CHROMATOGRAPHY IN RAT PLASMA." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2643–51. https://doi.org/10.5281/zenodo.883127.

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A Simple and rapid bioanalytical high performance liquid chromatographic (HPLC) method for the determination of Bosentan using Losertan as an internal standard was developed and validated as per regulatory requirements. Sample preparation was accomplished through liquid phase extraction and chromatographic separation on a reverse phase column. The mobile phase consists of mixture of methanol and water in the ratio of 50:50 at a flow rate of 1ml/min. The wavelength used for the detection of bosentan was 225nm with a total run time of 6minutes. The retention times of bosentan and losertan were f

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20

Dr., K. Bhavyasri, tasneem Sumaiya, and Mogili. Sumakanth Dr. "Development and Validation of a UV-Visible Spectrophotometer Method for Estimation of Etomidate Spiked in Human Plasma." Journal of Scientific and Engineering Research 8, no. 7 (2021): 166–71. https://doi.org/10.5281/zenodo.10609123.

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<strong>Abstract </strong>UV-visible spectrophotometer method for determination of etomidate in human plasma was developed and validated. Acetonitrile and water (75:25) as diluent. The absorption maximum for the drug was observed at 243nm in methanol. The calibration curve range from 5-60µg/ml. the % recovery was found to be 98-100%, the applicability of the method was examined by analysing the human plasma. The method was successfully applied for estimation of etomidate in pharmaceutical formulations.

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21

Rachmaniar, Revika, Natalia Suryanata, and Nela Simanjuntak. "VALIDASI METODE ANALISIS SENYAWA ETIL p-METOKSISINAMAT DALAM PLASMA DARAH TIKUS PUTIH JANTAN GALUR WISTAR MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI." Pharma Xplore Jurnal Ilmiah Farmasi 7, no. 1 (2022): 24–34. http://dx.doi.org/10.36805/farmasi.v7i1.2332.

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Ethyl p-methoxycinnamate (EPMC) isolated from the rhizome of kencur (Kaempferia galanga L) is being developed at STFI. Validation of EPMC analysis in blood plasma using High-Performance Liquid Chromatography (HPLC) needs to be conducted to perform in vivo EPMC analysis. This study aims to validate the EPMC analysis method in blood plasma using HPLC. The HPLC column used is column C18, with methanol : phosphoric acid 70:30 and 80:20 mobile phases, a flow rate of 1.0 mL/min, and a maximum wavelength of 310 nm. The blood plasma used was the blood plasma of white male rats of the Wistar strain. EP

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22

Sonkamble, Akhilkumar Gundu Dr. Satpute K. L. "Development and Validation of RP-HPLC Method for Simultaneous Estimation of Hydrochlorothiazide and Bisoprolol Fumarate in Pharmaceutical Dosage Form." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 2470–78. https://doi.org/10.5281/zenodo.13175222.

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A straightforward, focused, exact, and high-performance liquid chromatographic reverse phase approach was created for the simultaneous measurement of Hydrochlorothiazide and Bisoprolol Fumarate in tablet form. A 55:20:25 v/v/v mobile phase comprising TEA, acetonitrile, and methanol was employed in an isocratic mode Agilent. The effluent was measured at 225 nm, and the flow rate was 1 ml/min. Hydrochlorothiazide and Bisoprolol Fumarate had retention times of 3.79 and 9.71 minutes, respectively.

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Sonkamble, Akhilkumar Gundu* Dr. Satpute K. L. "Development and Validation of RP-HPLC Method for Simultaneous Estimation of Hydrochlorothiazide and Bisoprolol Fumarate in Pharmaceutical Dosage Form." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 2478–86. https://doi.org/10.5281/zenodo.13175668.

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A straightforward, focused, exact, and high-performance liquid chromatographic reverse phase approach was created for the simultaneous measurement of Hydrochlorothiazide and Bisoprolol Fumarate in tablet form. A 55:20:25 v/v/v mobile phase comprising TEA, acetonitrile, and methanol was employed in an isocratic mode Agilent. The effluent was measured at 225 nm, and the flow rate was 1 ml/min. Hydrochlorothiazide and Bisoprolol Fumarate had retention times of 3.79 and 9.71 minutes, respectively.

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24

Chuquin-Vasco, Daniel, Francis Parra, Nelson Chuquin-Vasco, Juan Chuquin-Vasco, and Vanesa Lo-Iacono-Ferreira. "Prediction of Methanol Production in a Carbon Dioxide Hydrogenation Plant Using Neural Networks." Energies 14, no. 13 (2021): 3965. http://dx.doi.org/10.3390/en14133965.

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The objective of this research was to design a neural network (ANN) to predict the methanol flux at the outlet of a carbon dioxide dehydrogenation plant. For the development of the ANN, a database was generated, in the open-source simulation software “DWSIM”, from the validation of a process described in the literature. The sample consists of 133 data pairs with four inputs: reactor pressure and temperature, mass flow of carbon dioxide and hydrogen, and one output: flow of methanol. The ANN was designed using 12 neurons in the hidden layer and it was trained with the Levenberg–Marquardt algori

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Mr., Nilesh Nikam, Avish Maru Dr., and Anil Jadhav |. Dr. Prashant Malpure Dr. "Analytical Method Development and Validation of Metformin Hydrochloride by using RP HPLC with ICH Guidelines." International Journal of Trend in Scientific Research and Development 3, no. 3 (2019): 415–19. https://doi.org/10.31142/ijtsrd22812.

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A simple and reproducible method was developed for Metformin MET by Reverse Phase High Performance Liquid Chromatography RP HPLC . Metformin was separated on C18 column 4.6x250mm, particle size 5µm , using combination of phosphate buffer with pH of 3.0 and Methanol at the UV detection of 238nm. Isocratic elution of phosphate buffer with pH of 3.0 and Methanol was used as a mobile phase with various ratios and flow rates, eventually 30 70 v v phosphate buffer with pH of 3.0 and Methanol was being set with the flow rate of 1mL min. The statistical validation parameters such as linearity, a

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Le, Thi Huong Hoa, Thi Hong Phung, and Dinh Chi Le. "Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder." Journal of Analytical Methods in Chemistry 2019 (March 7, 2019): 1–9. http://dx.doi.org/10.1155/2019/6143061.

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A novel HPLC method was developed and validated for simultaneous determination of potassium guaiacolsulfonate and sodium benzoate in pediatric oral powder. In this method, an analytical C8 column maintained at 25°C was used for chromatographic separation with a mixture of methanol and 0.02 M solution of tetrabutylammonium sulfate as the mobile phase. The composition of mobile phase was varied using a gradient program including an initial hold time of 7 minutes with methanol content maintained at 20% (v/v), followed by a linear gradient in 5.5 minutes in which methanol content was increased fro

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27

Rameshpetchi, Rajendran Devikasubramaniyan* Ramya Sri Sura M. Deepthishalini K. Sirisha K. Janaiah K. Kaveri L. Jyothi. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ZALEPLON IN PURE AND TABLET FORMULATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2103–9. https://doi.org/10.5281/zenodo.1214544.

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A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Zaleplon in its pure form as well as in tablet dosage form. Chromatography was carried out on XBridge C18 (4.6×150mm, 5µ) column using a mixture of Methanol (100%v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 253nm. The retention time of the Zaleplon was 2.4 ±0.02min. The method produce linear responses in the concentration range of 25-120µg/ml of Zaleplon. The method precision for the determination of assay wa

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28

R, Venkat Reddy *. Badugu Deepika N. Sunita M. Jaya Shankar SK. Nadeer K. Ravi Kumar Santosh Illendula G. Koteswar Rao K.N.V. Rao K. Rajeswar Dutt. "DEVELOPMENT AND VALIDATION OF UV-SPECTROSCOPIC METHOD FOR THE ESTIMATION OF METFORMIN IN BULK AND PHARMACEUTICAL DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2124–30. https://doi.org/10.5281/zenodo.1214550.

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A new simple, accurate, rapid, precise, reproducible and cost effective spectrophotometric method for the quantitative estimation of Metformin in bulk and pharmaceutical dosage form. The developed visible spectrophotometric method for the quantitative estimation of Metformin is based on measurement of absorption at maximum wavelength 242 nm using Methanol as a solvent. The stock solution of Metformin was prepared, and subsequent suitable dilution was prepared with methanol to obtained standard curve. The standard solution of Metformin shows absorption maxima at 242 nm. The drug obeyed beer lam

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Deepti, K., and A. Rai. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF DEFLAZACORT." INDIAN DRUGS 51, no. 04 (2014): 55–57. http://dx.doi.org/10.53879/id.51.04.p0055.

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UV spectrophotometric method has been developed for the estimation of deflazacort in pure and its pharmaceutical formulations. In UV method deflazacort showed absorption maximum at 242.8nm in methanol medium and it obeys Beers law in the concentration range of 5-25µg/mL.

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30

Casalegno, A., and R. Marchesi. "DMFC performance and methanol cross-over: Experimental analysis and model validation." Journal of Power Sources 185, no. 1 (2008): 318–30. http://dx.doi.org/10.1016/j.jpowsour.2008.06.071.

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31

Fell, Stephan, Paul Yu, and Nafissa Haimad. "Modelling Approach and Validation of a Methanol Steam-Reforming Reactor Model." Chemie Ingenieur Technik 73, no. 6 (2001): 630. http://dx.doi.org/10.1002/1522-2640(200106)73:6<630::aid-cite6302222>3.0.co;2-3.

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32

Nerdy, Nerdy. "DEVELOPMENT AND VALIDATION OF ULTRAVIOLET SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF MEBHYDROLINE NAPADISYLATE IN TABLET PREPARATIONS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 367. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16879.

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Objective : Mebhydrolin Napadisylate is classified as an antihistamine drug classes used to treat allergies. One of the quality requirements for drug preparation was active compound levels must meet the requirements as stated in the Pharmacopoeia or other standard books. The purpose of this study was to validate an ultraviolet spectrophotometric method of determination of Mebhydrolin Napadisylate in the tablet preparation available in the market.Methods : Solvents used are hydrochloric acid (HCl) 0.1 N in methanol and sodium hydroxide (NaOH) 0.1 N in methanol for determination of Mebhydrolin N

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33

Kumar, Basant. "Analytical Method Development and Validation of Ornidazole in Bulk and Dosage Form." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (2023): 1754–59. http://dx.doi.org/10.22214/ijraset.2023.53934.

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Abstract: In the given study, of an For the purpose of estimating ornidazole in bulk and dose form, an correct, exact, and specific approach has been established. by ultraviolet spectroscopy. Ornidazole belongs to the categories of antibacterial medications ( nitroimidazoles) also used to treat infections caused by anaerobic bacteria and protozoa. The procedure includes calculation of the absorbance of Ornidazole blend in Methanol water 1:9. The calibration curve method shows wavelength maxima for Ornidazole at 315 nm with Methanol water 1:9 in the wavelength having a correlation value of 0.99

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Jebaliya, Hetal, Madhavi Patel, Yashwant Jadeja, Batuk Dabhi, and Anamik Shah. "A Comparative Validation Study of Fluconazole by HPLC and UPLC with Forced Degradation Study." Chromatography Research International 2013 (December 4, 2013): 1–5. http://dx.doi.org/10.1155/2013/673150.

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The simplest stability indicating reversed phase Isocratic HPLC and UPLC methods has been developed and validated for the determination of fluconazole in bulk and solid pharmaceutical dosage form. A SunFire C18 (250 × 4.5 mm, 5 μm particle size) column has been used for HPLC and BEH C18 (100 × 2.1 mm, 1.7 μm particle size) column used for UPLC. The Mobile phase consisted of Methanol : Water (70 : 30) for HPLC and Methanol : Water (55 : 45 v/v) for UPLC. Isocratic flow was set at 1 mL/min and 0.30 mL/min, respectively, for HPLC and UPLC. For both HPLC and UPLC system detection has been performe

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Al-Madhagy, Somaia A., Nada M. Mostafa, Fadia S. Youssef, Ghada E. A. Awad, Omayma A. Eldahshan, and Abdel Nasser B. Singab. "Metabolic profiling of a polyphenolic-rich fraction of Coccinia grandis leaves using LC-ESI-MS/MS and in vivo validation of its antimicrobial and wound healing activities." Food & Function 10, no. 10 (2019): 6267–75. http://dx.doi.org/10.1039/c9fo01532a.

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Mukhsaf, Mohammed Hilal, Weiqin Li, and Ghassan Husham Jani. "Optimizing Methanol Injection Quantity for Gas Hydrate Inhibition Using Machine Learning Models." Applied Sciences 15, no. 6 (2025): 3229. https://doi.org/10.3390/app15063229.

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Estimating the minimal methanol required to inhibit gas hydrate formation in pipelines is vital for operational efficiency, cost reduction, and sustainability. This task is complex due to dynamic variables like flow rate, temperature, pressure, gas specific gravity, and water content. Machine learning offers a robust solution by leveraging pipeline condition data to effectively forecast methanol needs. We evaluated four models—extreme gradient boosting (XGBoost), random forest (RF), decision tree (DT), and k-nearest neighbors (KNN)—to predict the methanol quantities required for hydrate preven

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Y., Naveen Kumar, Divya B., and J. Sreekanth Dr. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ELBASVIR BY USING RP-HPLC." Journal of Pharma Research 7, no. 12 (2018): 342–48. https://doi.org/10.5281/zenodo.14227211.

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<strong>Abstract</strong> <strong>A</strong> rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Elbasvir, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Zorbax C18 (4.6 x 150mm, 5µm) column using a mixture of Methanol: Phosphate Buffer pH 3.9 (55:45v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 255nm. The retention time of the Elbasvirwas 2.061 ±0.02min. The method produce linear responses in the concentration range of 1-5µg/ml o

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Jeong, Min Kyu, Chan Uk Park, Min Hee Park, et al. "Validation of HPLC Methods for Ascorbic Acid and Its Derivatives in Foods." Food Engineering Progress 15, no. 1 (2011): 75–79. http://dx.doi.org/10.13050/foodengprog.2011.15.1.75.

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Analytical methods for food antioxidants including ascorbic acid, erythorbic acid, ascorbyl palmitate (AP), and ascorbyl stearate (AS), were validated using high performance liquid chromatography. Validation parameters such as linearity, limit of detection (LOD), limit of quantification (LOQ), and recovery were tested using lard and cider as food model systems. Linearity of ascorbic acid and erythorbic acid were both higher than (R2> 0.99), LOD of these compounds were 0.46 and 0.48 μg/mL, respectively and LOQ were 1.39 and 1.45 μg/mL, respectively. The recovery rates of these compounds were

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Zilhadia Zilhadia, Supandi Supandi, and Adha Dastu Ilahi. "A simple Simultaneous UV Spectrophotometric Method to Determine Isoniazid and Rifampicin Contents in One Combined Tablet." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1982–88. http://dx.doi.org/10.26452/ijrps.v11ispl4.4407.

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Isoniazid and rifampicin are the first-line anti-tuberculosis drugs in the advanced phase. This study aimed at validating the method to determine the levels of isoniazid and rifampicin contents in one serve of combined tablet circulating at Pramuka market using simultaneous analysis of Ultraviolet Spectrophotometry with methanol as a solvent. The maximum wavelength of isoniazid and rifampicin obtained was 261 nm and 337 nm, respectively. The method used to confirm the validity here includes linearity, the limit of detection (LOD), limit of quantitation (LOQ), accuracy, and precision under the

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G., K. Mallaiah* P. Vivek Sagar2. "Method development and Validation of Axitinib in Bulk and Pharmaceutical dosage form by RP- HPLC." Journal of Pharma Research 7, no. 12 (2018): 295–99. https://doi.org/10.5281/zenodo.6967274.

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<strong>ABSTRACT</strong> A simple, rapid, precise and accurate RP-Hplc method was developed and validated for the determination of Axitinib, in bulk and pharmaceutical dosage form. The separation is achieved on RP-HPLC using a PDA detector by incorporation of empower 2 software with a flow rate of 1.0ml/min using a mixture of Methanol and water (15:85% v/v) as mobile phase. The column used was Hypersil C18 (4.6×150mm, 5μ) at a wave length of 284nm. The retention time of the Axitinib was 3.515min. The linearity of the drug was 25-125μg/m and the method precision for the determinati

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Pramod, Singh Punam Kumar Neha Paliwal &. Kajal Jaiswal. "VALIDATION OF DIFFERENT METHODS COMPARING WITH THEIR SPECIFICITY." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES [FRTSSDS-18] (June 13, 2018): 56–58. https://doi.org/10.5281/zenodo.1288422.

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In literature it is mentioned that different organic solvents (methanol, ethanol, water, acetone and 80% ethanol) are used for the extraction of phytochemical from plants. In this paper we attempted to analyze all these organic solvents and tried to find out that which one is the most suitable solvent for the extraction of phytochemical.  One variety of chickpea genotype (JAKI9218) was collected from College of Agriculture, Sehore, Madhya Pradesh. Seed coat were removed and crushed into fine powder. Phytochemicals were isolated using soxhlet apparatus with various solvents. Extract was in

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Carlos, Esteban Aristizabal Alzate, Nel Alvarado Torres Pedro, and Felipe Vargas Ramírez Andrés. "Simulation of methanol production from residual biomasses in a Cu/ZnO/Al2O3 packed bed reactor." Revista Facultad de Ingeniería, Universidad de Antioquia, no. 102 (September 23, 2020): 115–24. https://doi.org/10.17533/udea.redin.20200907.

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This article aims to simulate an algorithm constructed in MATLAB to represent the catalytic conversion of SYNGAS into methanol in a packed-bed reactor, based on chemical kinetics for a heterogeneous system with a Cu/ZnO/Al2O3 as a catalyst, and complementary math and phenomenological models, as a pressure drop and catalyst deactivation. Model validation is developed, comparing reference results and the results by running the algorithm in MATLAB using a reference SYNGAS composition. Also, the constructed model considers a catalyst deactivation by sintering and pressure drop along the reactor. S

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Lohiya, G. V. Mahima Jadhav Rohini Ghotmukle Shivnechari P. M. Birajdar M. J. Kulkarni Y. P. Satpute K. L. "RP HPLC Method Development and Validation on Dapagliflozin." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1766–79. https://doi.org/10.5281/zenodo.12806716.

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Analytical techniques encompass a broad spectrum of methods and practices essential for ensuring the quality of medicinal products. These techniques are crucial for the design, development, standardization, and quality control of pharmaceuticals. The quality of drug products is paramount because it directly impacts patient safety and treatment efficacy. Therefore, stringent manufacturing processes and quality control measures are indispensable components of robust primary healthcare systems globally.Pharmaceutical analysis, a specialized area within pharmacy, is pivotal in maintaining the qual

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Holman, Miranda Kay, Stacy D. Brown, Dorcas Frempong, Ashana Puri, and Steven Dinh. "Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for Determination of Cromolyn Sodium in Skin Permeation Studies." Journal of Analytical Methods in Chemistry 2022 (April 21, 2022): 1–11. http://dx.doi.org/10.1155/2022/7437905.

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Cromolyn sodium (CS) is a mast cell stabilizer administered to treat allergic diseases. A topical system would sustain its delivery and may be designed for treatment of atopic dermatitis. Established HPLC protocols for detection of CS are time consuming and intensive, indicating the need for a more streamlined method. This study aimed at developing and validating a sensitive and selective LC-MS method for quantifying CS in skin permeation studies that was less time and resource demanding. The optimized method involved an isocratic mobile phase (10 mM NH4HCO3, pH 8.0, 90% and ACN, 10%) at a flo

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Nguyen Duc, Hoang, and Canh Tran Quang. "Simultaneous determination of acetaldehyde, ethyl acetate, methanol, iso butanol, and iso almyacol concentrations in white alcol in some areas in Hai Duong province in 2018 - 2019." Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam 3, no. 3 (2020): 196–203. http://dx.doi.org/10.47866/2615-9252/vjfc.1720.

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The research has developed a method for simultaneous determination of acetaldehyde, ethyl acetate, methanol, isobutyl alcohol, isoamyl alcohol in white alcohol. Validation results show that the method has satisfactory accuracy with recovery in the range of 105 - 108%, repeatability RSD &lt; 1.57%, detection limit below 3 mg/L for all compounds. Proficiency test results in 2020 were satisfactory with Z-scores of all substances below 2. The method has been applied to analyze 200 distilled alcohol samples and 50 blended alcohol samples taken in Hai Duong city during the period from 2018 to 20

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Singh, Abhinav, K. Nagarajan, Parul Grover, and Richa Goel. "Method Development and Validation of Quetiapine Fumerate by Using RP-HPLC." Oriental Journal Of Chemistry 40, no. 5 (2024): 1220–31. http://dx.doi.org/10.13005/ojc/400503.

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A rapid, precise, and selective reverse-phase high-performance liquid chromatography (RP-HPLC) method was established and validated for the analysis of QTPF (QUETIAPINE FUMERATE) pure drug as well as commercial formulation. This RP-HPLC approach is designed for the regular determination of QTPF in both laboratory-prepared mixtures and combined pharmaceutical formulations. The separation process utilized an INERTSIL C-18 ODS column (physical dimension 250×4.6mm, 5µm particle size), employing a mobile phase of methanol and ammonium acetate (30 Mm) in a 95:5 ratio, with a flow rate of 1ml/min. Th

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Rameshpetchi, Rajendran Devikasubramaniyan* Ramya Sri Sura R. Swathi R. Sainandhan Rao K. Sindhu D. Lavanya. "VALIDATED HPLC METHOD FOR ESTIMATION OF BALOFLOXACIN IN BULK AND DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2040–46. https://doi.org/10.5281/zenodo.1214525.

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A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Balofloxacin, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Sunfire C18 (4.6×150mm, 5µm) column using a mixture of Methanol: Water (50:50 v/v) as the mobile phase at a flow rate of 0.9ml/min, the detection was carried out at 245nm. The retention time of the Balofloxacin was 2.6 ±0.02min. The method produce linear responses in the concentration range of 35-175µg/ml of Balofloxacin. The method precision for the

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Rameshpetchi, Rajendran Devikasubramaniyan* Ramya Sri Sura E.Veeranna G.Chandraprabha G.Kiranmai G.Tharunkumar. "RP-HPLC PDA METHOD FOR ESTIMATION OF PRULIFLOXACIN IN BULK AND PHARMACEUTICAL DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2088–94. https://doi.org/10.5281/zenodo.1214538.

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A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Prulifloxacin in its pure form as well as in tablet dosage form. Chromatography was carried out on Symmetry C18 (4.6×150mm, 5µ) column using a mixture of Methanol and water (85:15 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 242nm. The retention time of the Prulifloxacin was 3.0 ±0.02min. The method produce linear responses in the concentration range of 15-75µg/ml of Prulifloxacin. The method precision for th

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Rameshpetchi, Rajendran Devikasubramaniyan* Ramya Sri Sura V. Sunil M. Bhrath Kumar P.Gopinath S. Naresh. "RP-HPLC PDA METHOD FOR ESTIMATION OF ZANAMIVIR IN API AND PHARMACEUTICAL FORMULATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2110–16. https://doi.org/10.5281/zenodo.1214546.

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A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Zanamivir in its pure form as well as in tablet dosage form. Chromatography was carried out on Sunfire C18 (4.6×150mm, 5µ) column using a mixture of Methanol and water (95:5 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 285nm. The retention time of the Zanamivir was 2.6 ±0.02min. The method produce linear responses in the concentration range of 40-200µg/ml of Zanamivir. The method precision for the determinati

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Jong, Jacob De, Bernd Stoisser, Karl Wagner, et al. "Determination of Maduramicin in Feedingstuffs and Premixtures by Liquid Chromatography: Development, Validation, and Interlaboratory Study." Journal of AOAC INTERNATIONAL 87, no. 5 (2004): 1033–41. http://dx.doi.org/10.1093/jaoac/87.5.1033.

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Abstract A reversed-phase liquid chromatography method for determination of maduramicin in feedingstuffs and premixtures was developed, validated, and interlaboratory studied. The extraction solvent was methanol. Maduramicin was detected at 520 nm after postcolumn derivatization with vanillin.

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