Academic literature on the topic 'Methimazol'
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Journal articles on the topic "Methimazol"
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Perger, Ludwig, Ulrich Bürgi, and Karin Fattinger. "Pharmakotherapie bei Hyperthyreose - unerwünschte Arzneimittelwirkungen." Therapeutische Umschau 68, no. 6 (June 1, 2011): 303–8. http://dx.doi.org/10.1024/0040-5930/a000169.
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Als Thyreostatika werden heute Thioimidazole (Carbimazol, Methimazol = Thiamazol) und Propylthiouracil eingesetzt. Carbimazol wird im Körper in Methimazol umgewandelt; ein Wechsel zwischen diesen Substanzen bringt bei Nebenwirkungen nichts. Des Weiteren kommt es bei Nebenwirkungen zwischen Thioimidazolen und Propylthiouracil manchmal zu Kreuzreaktionen. Zu den häufigen und typische Nebenwirkungen der Thyreostatika gehört eine dosisabhängige Hypothyreose, die Schilddrüsenfunktion soll deshalb regelmäßig überwacht werden. Weiter kann es zu Juckreiz und Hautausschlag kommen; hier kann man einen Wechsel der Substanz versuchen. Neben einer milden, dosisabhängigen Neutropenie, kann es vor allem in den ersten drei Monaten auch zu einer schweren Agranulozytose (3 per 10'000 Patienten, Kreuzreaktionen möglich) und sehr selten zu aplastischer Anämie kommen. Vor allem unter Propylthiouracil, aber selten auch unter Methimazol können ein asymptomatischer, transienter Leberenzymanstieg, aber auch schwere, ja tödlich verlaufende cholestatische oder hepatozelluläre Leberschäden auftreten. Wegen der Häufung von Propylthiouracil-bedingtem Leberversagen bei Kindern und Jugendlichen, sollte man hier präferentiell Thioimidazole einsetzen. Wegen dieser schweren Nebenwirkungen sollen Patienten unter Thyreostatika angewiesen werden, sich bei Auftreten von Fieber oder Halsschmerzen bzw. Malaise, Oberbauchbeschwerden und Ikterus umgehend beim Arzt zu melden. Des Weiteren kann es unter beiden Substanzen bei 1 - 5 % zu Arthralgien kommen. Da sich daraus schwere immunologische Nebenwirkungen entwickeln können, sollen die Thyreostatika dann abgesetzt werden. Eine Polyarthritis tritt vor allem in den ersten Monaten der Therapie auf, während ANCA-positive Vasculitiden oft erst nach langer Therapiedauer mit Propylthiouracil oder sehr selten unter Methimazol auftreten können. Das teratogene Risiko ist bei den Thioimidazolen höher (Aplasia cutis congenita), weswegen in der Schwangerschaft Propylthiouracil bevorzugt werden soll. In der Stillzeit können sowohl Thioimidazole als auch Propylthiouracil verabreicht werden. Perchlorat wir heute kaum mehr verwendet. Deswegen sind die früher unter längerer Therapie mit Perchlorat beobachteten Nebenwirkungen heute kaum mehr ein Thema.
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Laurberg, P., J. Tørring, and J. Weeke. "A comparison of the effects of propylthiouracil and methimazol on circulating thyroid hormones and various measures of peripheral thyroid hormone effects in thyrotoxic patients." Acta Endocrinologica 108, no. 1 (January 1985): 51–54. http://dx.doi.org/10.1530/acta.0.1080051.
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Abstract. Two groups of patients with newly diagnosed thyrotoxicosis were treated with propylthiouracil (PTU) 400 mg every 6 h for 4 days followed by methimazol (MMI) 40 mg every 6 h for 4 days or by MMI for 4 days followed by PTU for 4 days. The shift from MMI to PTU induced a considerable decrease in serum T3 while shift from PTU to MMI led to an increase in serum T3. Serum T4 decreased gradually during the whole treatment period. The opposite variations in serum T3 were accompanied by similar opposite variations in basal metabolic rate (BMR) (P < 0.001). Hence the rapid variations in serum T3 which can be induced by PTU in thyrotoxic patients, are followed by rapid alterations in the thyrotoxic state as evaluated by BMR.
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Frank-Raue, Karin. "Schilddrüse und Schwangerschaft." Der Klinikarzt 48, no. 12 (December 2019): 541–45. http://dx.doi.org/10.1055/a-1061-0678.
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ZUSAMMENFASSUNGIn der Schwangerschaft nimmt die Produktion von Thyroxin um etwa 50 % zu, der Jodbedarf steigt, das Schilddrüsenvolumen nimmt zu. Die Therapie von Schilddrüsenerkrankungen betrifft Mutter und Kind, die Plazentagängigkeit von Jod, Thyreostatika und TSH-Rezeptorantikörpern in höheren Titern ist zu beachten, Thyroxin ist nur partiell plazentagängig.Im 1. Trimenon ist die meist milde durch hCG-Stimulation bedingte Schwangerschaftshyperthyreose die häufigste Ursache einer Hyperthyreose, sie ist meist nicht behandlungsbedürftig. Die Hyperthyreose bei M. Basedow tritt in etwa 0,2 % der Schwangerschaften auf; Therapieindikation ist die manifeste Hyperthyreose. In der Frühschwangerschaft wird mit Propylthiouracil, ab dem 2. Trimenon mit Methimazol/Carbimazol behandelt.Die Hypothyreose der Mutter ist mit Schwangerschaftskomplikationen und Entwicklungsstörungen des Kindes assoziiert. Die Thyroxindosis muss bereits in der Frühschwangerschaft erhöht werden. Die Behandlung von TSH-Spiegeln zwischen 2,5–4 mIU/l verbessert weder die Abortrate noch die fetale kognitive Entwicklung. Eine L-Thyroxintherapie ist ab einer TSH-Erhöhung von 4 mIU/l indiziert.
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Arizmendi Diana Elizabeth, Díaz, and Mendieta Zerón Hugo. "Degree of Control and Main Complications of Hyperthyroid Pregnant Women in a Real Life Experience with Methimazol." American Journal of Internal Medicine 8, no. 1 (2020): 19. http://dx.doi.org/10.11648/j.ajim.20200801.14.
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Tu, Changqing, and Xinrong Wen. "Determination of Cysteine by Discoloration Spectrophotometry using Copper(II)-Bis-Cyclohexanone Oxalydihydrazone." E3S Web of Conferences 245 (2021): 03023. http://dx.doi.org/10.1051/e3sconf/202124503023.
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In the alkaline medium of pH=9.18, Cu2+ can be reduced to Cu+ by the sulfhydryl (-SH) of cysteine, and it result in the decrease the amount of Cu2+ in the system. The decrement of Cu2+ is directly proportional to the addition of cysteine, then using bis-cyclohexanone oxalyldihydrazone (BCO) as chromogenic reagent for Cu2+ to determinate the content of cysteine indirectly by discoloration spectrophotometry. A new method for the determination of cysteine by discoloration spectrophotometry using Copper(II)-BCO has been established. The influencing factors of the determination of cysteine is investigated. The results show that the maximum absorption wavelength of chromogenic system was 602 nm, in the range of 0.008000~0.06800 mg/mL, the linear relationship between the decrease of absorbance and the mass concentration of methimazol is A=0.2162+2.4824C (mg/mL), and the linear correlation coefficient is r=0.9959. The method has been applied to the determination of cysteine in food, and the results are basically consistent with those determined by pharmacopoeial method.
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Mano, T., R. Sinohara, Y. Sawai, N. Oda, Y. Nishida, T. Mokuno, K. Asano, et al. "Changes in lipid peroxidation and free radical scavengers in the brain of hyper- and hypothyroid aged rats." Journal of Endocrinology 147, no. 2 (November 1995): 361–65. http://dx.doi.org/10.1677/joe.0.1470361.
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Abstract To determine how lipid peroxides and free radical scavengers are changed in the brain of hyper- or hypothyroid rats, we examined the behavior of lipid peroxide and free radical scavengers in the cerebral cortex of aged (1·5 years old) rats that had been made hyper- or hypothyroid by the administration of thyroxine or methimazol for 4 weeks. Concentrations of catalase, Mn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were increased in hyperthyroid rats compared with euthyroid rats. Concentrations of total SOD, Cu,Zn-SOD and GSH-PX were increased but that of Mn-SOD was decreased in hypothyroid animals. There were no differences among hyperthyroid, hypothyroid and euthyroid rats in the levels of coenzymes 9 or 10. The concentration of lipid peroxides, determined indirectly by the measurement of thiobarbituric acid reactants, was decreased in hyperthyroid rats but not in hypothyroid rats when compared with euthyroid animals. These findings suggest that free radicals and lipid peroxides are scavenged to compensate for the changes induced by hyper- or hypothyroidism. Journal of Endocrinology (1995) 147, 361–365
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Mano, T., R. Sinohara, Y. Sawai, N. Oda, Y. Nishida, T. Mokuno, M. Kotake, et al. "Effects of thyroid hormone on coenzyme Q and other free radical scavengers in rat heart muscle." Journal of Endocrinology 145, no. 1 (April 1995): 131–36. http://dx.doi.org/10.1677/joe.0.1450131.
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Abstract Active oxygen species are reported to cause organ damage. This study was therefore designed to determine the behaviour of antioxidants and free radical scavengers so as to reveal changes in animals in the hyper- and hypothyroid state. Levels of antioxidant factors (i.e. coenzyme Q (CoQ)10, CoQ9 and vitamin E) and free radical scavengers (catalase, glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD)) were measured in the heart muscles of rats rendered hyper- or hypothyroid by 4 weeks of thyroxine (T4) or methimazol treatment. Serum levels of CoQ9 and total SOD were also measured. A significant reduction in CoQ9 levels was observed in the heart muscles of both hyper- and hypothyroid rats when compared with control hearts. There was no difference in serum CoQ9 levels in thyroid dysfunction when compared with control animals. Levels of vitamin E in the heart muscles of hyperthyroid rats were significantly increased, and there was no reduction in vitamin E levels in hypothyroid rats when compared with control hearts. GSH-PX levels in the heart muscle were reduced in hyperthyroid rats and increased in hypothyroid rats when compared with control hearts. However, there were no differences in catalase levels in heart muscle between hyper- and hypothyroid rats. The concentration of SOD in heart muscle was increased in hyperthyroid rats and was not decreased in hypothyroid rats compared with control rats, suggesting the induction of SOD by excessive production of O2−. These data suggest that the changes in these scavengers have some role in cardiac dysfunction in the hyper- and hypothyroid state in the rat. Journal of Endocrinology (1995) 145, 131–136
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Sykora, Matus, Barbara Szeiffova Bacova, Tamara Egan Benova, Miroslav Barancik, Jitka Zurmanova, Hana Rauchova, Peter Weismann, et al. "Cardiac Cx43 and ECM Responses to Altered Thyroid Status Are Blunted in Spontaneously Hypertensive versus Normotensive Rats." International Journal of Molecular Sciences 20, no. 15 (August 1, 2019): 3758. http://dx.doi.org/10.3390/ijms20153758.
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Heart function and its susceptibility to arrhythmias are modulated by thyroid hormones (THs) but the responsiveness of hypertensive individuals to thyroid dysfunction is elusive. We aimed to explore the effect of altered thyroid status on crucial factors affecting synchronized heart function, i.e., connexin-43 (Cx43) and extracellular matrix proteins (ECM), in spontaneously hypertensive rats (SHRs) compared to normotensive Wistar Kyoto rats (WKRs). Basal levels of circulating THs were similar in both strains. Hyperthyroid state (HT) was induced by injection of T3 (0.15 mg/kg b.w. for eight weeks) and hypothyroid state (HY) by the administration of methimazol (0.05% for eight weeks). The possible benefit of omega-3 polyunsaturated fatty acids (Omacor, 200 mg/kg for eight weeks) intake was examined as well. Reduced levels of Cx43 in SHRs were unaffected by alterations in THs, unlike WKRs, in which levels of Cx43 and its phosphorylated form at serine368 were decreased in the HT state and increased in the HY state. This specific Cx43 phosphorylation, attributed to enhanced protein kinase C-epsilon signaling, was also increased in HY SHRs. Altered thyroid status did not show significant differences in markers of ECM or collagen deposition in SHRs. WKRs exhibited a decrease in levels of profibrotic transforming growth factor β1 and SMAD2/3 in HT and an increase in HY, along with enhanced interstitial collagen. Short-term intake of omega-3 polyunsaturated fatty acids did not affect any targeted proteins significantly. Key findings suggest that myocardial Cx43 and ECM responses to altered thyroid status are blunted in SHRs compared to WKRs. However, enhanced phosphorylation of Cx43 at serine368 in hypothyroid SHRs might be associated with preservation of intercellular coupling and alleviation of the propensity of the heart to malignant arrhythmias.
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Shell, Abigail, and Joshua W. Sullivan. "Acute Kidney Injury Following Methimazole Initiation: A Case Report." Journal of Pharmacy Practice 33, no. 1 (August 15, 2018): 99–101. http://dx.doi.org/10.1177/0897190018789277.
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Objective: Nephritis has been rarely associated with methimazole, primarily in the development of nephrotic syndrome. We describe a case of acute kidney injury without evidence of nephrotic syndrome following methimazole initiation. Methods: We present the relevant history, laboratory data, and nuclear medicine data and review relevant documentation from the literature. Results: A 72-year-old male recently diagnosed with new-onset atrial fibrillation was found to have suppressed thyroid-stimulating hormone (TSH) levels; elevated free T3, T4, and thyroid-stimulating immunoglobulin (TSI) levels; and a nonnodular thyroid gland with normal iodine uptake. He was diagnosed with Graves’ disease and treated with propylthiouracil (PTU) for 5 years. When his poor compliance with PTU was impeding his antithyroid treatment, he was converted to methimazole. Within 1 month following methimazole initiation, his serum creatinine (SCr) had risen to 1.6× baseline in the absence of other contributing nephrotoxins. SCr returned to baseline within 2 weeks of methimazole discontinuation, and the patient was subsequently managed on PTU. Conclusion: Acute kidney injury with or without the presence of nephrotic syndrome may occur during treatment with methimazole. Renal function should be closely monitored after the initiation of methimazole to prevent progressive renal dysfunction.
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Elfarra, Adnan A., Renee J. Duescher, Peter J. Sausen, Todd M. O'Hara, and A. James Cooley. "Methimazole protection of rats against gentamicin-induced nephrotoxicity." Canadian Journal of Physiology and Pharmacology 72, no. 10 (October 1, 1994): 1238–44. http://dx.doi.org/10.1139/y94-176.
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Methimazole was previously shown to protect rats, mice, and (or) dogs against cisplatin-, cephaloridine-, 2-bromohydro-quinone-, and S-(1,2-dichlorovinyl)-L-cysteine-induced nephrotoxicity. In this study, methimazole effects on gentamicin (GM) induced nephrotoxicity were examined. Rats given GM (40 mg/kg) twice daily for 10 days exhibited higher blood urea nitrogen (BUN) concentrations and severe necrosis of virtually all proximal tubules compared with saline-treated controls. Rats cotreated with methimazole (20 mg/kg) exhibited minimal proximal tubular necrosis and were protected against GM-induced increase in BUN concentrations, despite having higher kidney GM concentrations. Rats given GM alone for 3 days exhibited no proximal tubular necrosis and no elevation of BUN values. However, these rats exhibited an increase in nonprotein disulfide concentrations and a decrease in renal protein thiol and protein disulfide concentrations, as opposed to rats given GM and methimazole. Together the results show that methimazole was an effective antagonist of GM-induced nephrotoxicity. Methimazole did not inhibit GM renal uptake but may protect against GM-induced nephrotoxicity by acting as an antioxidant within the kidneys.Key words: nephrotoxicity, gentamicin, methimazole, protein thiols, nonprotein thiols.
Dissertations / Theses on the topic "Methimazol"
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Busch, Jan Hendrik [Verfasser], Syed G. [Akademischer Betreuer] Haider, and Peter [Akademischer Betreuer] Albers. "Die Wirkung von DEHP und Methimazol auf die Sertoli-Zellanzahl und Apoptose-Vorgänge im Rattenhoden / Jan Hendrik Busch. Gutachter: Syed G. Haider ; Peter Albers." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1035274132/34.
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Kahmann, Cindy. "Quantifizierung von DNA-Schäden an adhaerenten Zelllinien nach Bestrahlung mit 188 Re- bzw. Röntgenstrahlung unter Zugabe von Methimazol, Nicotinamid und Perchlorat durch den Comet Assay." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1219154119996-02487.
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Kahmann, Cindy. "Quantifizierung von DNA-Schäden an adhaerenten Zelllinien nach Bestrahlung mit 188 Re- bzw. Röntgenstrahlung unter Zugabe von Methimazol, Nicotinamid und Perchlorat durch den Comet Assay." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1219154119996-02487.
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Lance, Lea N., Rudy T. Chapman, and Diego J. Rodriguez-Gil. "Synaptic Connectivity After Methimazole-Induced Injury." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/43.
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Olfactory sensory neurons in the olfactory epithelium are responsible for detecting the odors we smell and are constantly dying. However, in order for the sense of smell to be maintained, the olfactory system has the unique ability to generate new neurons. After an olfactory sensory neuron is born in the olfactory epithelium, it must extend an axon towards the olfactory bulb in the central nervous system. Within the olfactory bulb, these axons make specific synaptic contacts with the dendritic processes of mitral cells, which are the main projection neurons from the olfactory bulbs into higher cortical areas in the brain. In addition to regeneration due to normal turnover, the olfactory system is also capable of recovery after an injury. The olfactory system’s ability to recover is remarkable because it is capable of regeneration after a mild injury (a portion of olfactory epithelium is removed) or a severe injury (in which the entire olfactory epithelium is removed.) A well-established model for producing a severe type of injury in the olfactory epithelium is by inducing a chemical ablation by a single injection of the drug methimazole. A specific interest in the regenerative process after injury is reestablishment of synaptic connections. We hypothesized that expression of synaptic markers will allow for establishing a timeline of functional recovery of the olfactory system after injury. Our lab has studied three synaptic vesicle associated proteins, vesicular glutamate transporter -1 (VGlut-1), vesicular glutamate transporter-2 (VGlut-2), and synaptophysin, as well as one activity-regulated protein, tyrosine hydroxylase. These studies found specific temporal expression profiles at 2, 7 and 14 days post injury. Our initial data show that VGlut-1 and VGlut-2 are decreased after injury, indicative of a reduction in synaptic connectivity in both olfactory sensory neuron axons and in dendrites of mitral cell neurons. These changes in synaptic connectivity help in understanding functional connectivity after an injury and can further be used to correlate histological axonal tracing with behavioral studies.
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Chapman, Rudy T., and Diego J. Rodriguez-Gil. "Engulfment of Axonal Debris After Methimazole-Induced Injury." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/103.
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Neurons in the olfactory epithelium that are responsible for detecting the odors we smell are constantly dying. However, the olfactory system has the unique ability to regenerate new neurons in order for the sense of smell to be maintained. After a new sensory neuron is born in the olfactory epithelium, it must extend a new axon that will travel to the olfactory bulb and make specific synaptic contact so that the odor information from the epithelium can be coded and sent to the higher cortical areas of the brain. The olfactory system’s ability to recover is also even more complex in that it is capable of regeneration after an injury in which a portion or even the entire olfactory epithelium is removed. A well established model for this type of injury in the olfactory epithelium is by inducing a chemical ablation by injection of the drug methimazole. A specific interest in the regenerative process after injury is the mechanism by which axonal debris from the dead neurons is removed. After ablation of the olfactory epithelium, the cell bodies of the neurons detach but their axons remain intact. The axonal debris must not only be removed, but must also be done so in a way that minimizes inflammation in order for new axons to be able to extend to the olfactory bulb. Axonal debris removal has been characterized both in vitro and during development. However, the mechanism of debris removal has yet to be characterized after an injury. Our lab has studied different engulfment proteins in the olfactory bulb after injury using RT-qPCR and found specific temporal expression profiles at 3, 14 and 21 days post injury. Our initial investigations involved some known engulfment proteins such as Jedi1, GULP, and Megf10. However, we found that these proteins are downregulated after an injury. Further investigation has shown that the proteins Cd11b and TLR2 are upregulated after injury. These changes in expression can begin to shed light on the mechanism of axonal debris removal after an injury and can further be used to study how inflammation is suppressed in order to allow for axon extension and synaptic contact to be reestablished.
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Chapman, Rudy T., Katherine C. Burgess, Russ W. Brown, and Diego J. Rodriguez-Gil. "Axonal regrowth of olfactory sensory neurons after chemical ablation with methimazole." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/17.
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The olfactory system is of great interest in research due to the olfactory epithelium’s regenerative capability and as a potential as a source of neural stem cells. The olfactory sensory neurons are constantly being replaced by the stem cells that lie at the base of the olfactory epithelium. These stem cells also remain intact after an injury to the epithelium and lead to the regeneration of the olfactory epithelium. We have developed a fate mapping technique to trace axonal regrowth from newly born olfactory sensory neurons using an inducible Cre-ERT2 model after chemical ablation by the drug methimazole. Our data shows that newly generated olfactory sensory neurons labeled 1 day after chemical ablation by injection of 4-HO-tamoxifen extend an axon that reaches the olfactory bulb and extend to the glomeruli in a timeline that is consistent with control mice that received 4-HO-tamoxifen but were injected with saline 1 day prior. In addition, we assessed the functional recovery of the olfactory epithelium by testing the ability of mice to find a hidden cookie after methimazole injection. Mice were tested at 3 and 14 days post methimazole. There was a severe impairment in the ability to find a hidden cookie at 3 days post methimazole. The mice tested at 14 days post methimazole showed an improvement in the ability to find the cookie but the latency to find the cookie was still significantly higher than controls. In conclusion, while we demonstrate that axons extend to the olfactory bulb and the glomeruli earlier than 14 days, our behavioral data suggest that there must be a critical number of axons that must reach each specific glomerulus to regain function of the olfactory system.
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McGroarty, J. A. "The influence of methimazole and its putative metabolites on human polymorphonuclear Leucocyte function." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381470.
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Vignado, Jane. "Efeito do hipotireoidismo induzido experimentalmente com methimazole sobre o testiculo de ratos de varias idades." [s.n.], 1995. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314178.
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Orientador: Ernesto Jose DoltavianoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Embora seja do conhecimento geral que os hormônios tireoidianos estão envolvidos no desenvolvimento e manutenção de vários órgãos, ainda, existem aspectos contraditórios sobre seu papel na fisiologia testicular. Com a proposta de melhor compreender a influência dos hormônios tireoidianos na manutenção testicular, este estudo teve como objetivo avaliar parâmetros biométricos, morfológicos e hormonais em ratos de várias idades, que foram induzidos experimentalmente ao hipotireoidismo com doses diárias de 0,05 mg de Methimazole, confirmado pelas dosagens de Tiroxina (T4). Neste estudo utilizaram-se 68 ratos brancos (Rattus no veraicus, variedade albino), machos e 12 fetos. Estes animais foram sub divididos em 6 grupos experimentais, de acordo com o tempo de tratamento e a data do sacrifício e denominados: Hipotireoidismo materno-fetal (19º dia de vida fetal), 8 dias de idade, 21 dias de idade, 35 dias de idade, 50 dias de idade e 90 dias de idade. Os resultados mostraram que a indução do hipotireoidismo no oitavo dia de prenhez, que corresponde ao início da organogênese do rato, não resulta em aumento da incidência de reabsorção fetal ou de malformações congênitas e também não leva a alterações no comportamento dos animais com hipotireoidismo. Em todos os grupos experimentais analisados, os animais tratados apresentaram redução significativa (p<0,05) do peso corporal em relação aos animais controles da mesma idade. A avaliação biométrica dos testículos mostrou que os animais tratados apresentaram redução significativa (p<0,05) do peso testicular, do diâmetro dos túbulos seminíferos e do volume nuclear das células de Sertoli. Apenas os fetos com 19 dias de vida intra-uterina não mostraram diferenças nos parâmetros acima citados. A morfologia dos testículos dos animais tratados mostrou atraso no início do estadiamento do ciclo do epitélio seminífero, com redução da quantidade de células germinativas e aumento do número de células degeneradas. Nos grupos experimentais 50 dias e 90 dias de idade, os animais tratados apresentaram estadiamento completo do epitélio seminífero, mas a frequência dos estádios I, VII/VIII e XIV foi menor do que a dos animais controles da mesma idade. As dosagens em duplicata da testosterona plasmática, pelo método de fluoroimunoensaio de fase sólida, não mostraram diferenças significativas entre os valores encontrados nos animais controles e tratados. Conclui-se que o hipotireoidismo prejudica acentuadamente a espermatogênese dos ratos jovens, prejuízo detectável através da redução do peso testicular, da diminuição do diâmetro dos túbulos seminíferos, do aumento de células germinativas degeneradas, do atraso da espermatogênese e da redução do volume nuclear das células de Sertoli. Nos animais tratados com 90 dias de idade, ocorre ganho consideravelmente maior do peso testicular, do diâmetro dos túbulos seminíferos em relação aos animais controles da mesma idade e aparente estabilização no volume nuclear das células de Sertoli, sugerindo ausência da participação dos hormônios tireoidianos sobre o testículo do rato adulto
Abstract: Although it is well known that thyroidal hormones are involved in the development and maintenance of many organs, there remain several open questions as to their role in testicular physiology. The present work proposes to contribute to a better understanding of the role of thyroidal hormones in testicular maintenance. The evaluation was based on the biometric, morphologic and hormonal parameters of groups of data of different ages in which a previous experimental hypothyroidism was induced by treating them with daily 0,05mg Methimazole, and confirmed by measuring thyroxine levels. Our study involved an experimental of 68 white male rats and 12 foetuses (albino Rattus novergicus). These animals were subdivided into 6 experimental groups according to the period of treatment and their death date and will here be designated as mother-foetal ( 190 days of intrauterine life), 8 day old, 21 day old, 35 day old, 50 day old and 90 day old hypothyroidism, respectively. Our results showed that induction to hypothyroidism in the eighth day of pregnancy, which corresponds to the beginning of organogenesis in rats, did not result in any increase in the incidence of either foetal reabsorption nor congenital malformations, as well not causing behavioral alteration of animals with hypothyroidism. In all of the experimental groups considered, the treated animals have a significant reduction (p<0,05) in body weight as related to the control animals of same age. Biometric evaluation of testicles has shown that treated animals had significant reduction (p<0,05) in both the testicular weight and the diameter of seminiferous tubules as well as a reduction in the nuclear volume of Sertoli cells. Only the foetuses having 19 days of intrauterine life had no differences in such parameters, while in the treated 90 day old animals testicular recuperation was observed. As to the morphology, the testicular development of treated animals was delayed in the beginning of the seminiferous epithelium cycle, with a reduction in the quantity of germinative cells and an increase in the number of degenerated cells. In both the 50 and 90 day old experimental groups, the treated animals completed staging of the seminiferous epithelium, but the frequency of stages I, VII/VIII and XIV was reduced as compared to the control animals of the same age. Duplicated dosages of plasmic testosterone by means of solid phase fluoroimunoassays showed no significant differences in the values found for both treated and control animals. We conclude that hypothyroidism severely impairs espermatogenesis in young rats as indicated by the reduced testicular weight, the diminished seminiferous tubule diameter, the increased degeneration of germinative cells, the delayed staging in the seminiferous epithelium cycle and the reduced nuclear volume in Sertoli cell. This did not occur in adults rats. In treated animals belonging to the 90 day old experimental group we have observed the occurence of significantly larger gain in both the testicular weight and the seminiferous tubule diameter, as compared to the control animals of the same age, as well as the occurrence an apparent stabilization of the nuclear volume of Sertoli cells, which thereby suggest that there is no influence of the thyroidal hormones upon adult rats testicles
Mestrado
Fisiologia
Mestre em Ciências Biológicas
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Fonseca, Cláudia Sampaio [UNESP]. "Associação do methimazole e do ondansetron à quimioterapia com cisplatina em cães submetidos à quatro diferentes protocolos de fluidoterapia." Universidade Estadual Paulista (UNESP), 2002. http://hdl.handle.net/11449/101164.
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fonseca_cs_dr_jabo.pdf: 347869 bytes, checksum: 2e79231f69a8f91eea4c79be2928563c (MD5)A cisplatina é um agente antineoplásico utilizado em oncologia veterinária, sendo indicada no tratamento adjuvante de várias neoplasias, contudo, sua eficácia terapêutica é, muitas vezes, limitada por seu efeito nefrotóxico e emetogênico. Neste estudo, objetivou-se avaliar um novo protocolo quimioterápico, utilizando associação do methimazole e do ondansetron à cisplatina, além de tentar minimizar o tempo de fluidoterapia. Foram utilizados 12 cães, machos, divididos em quatro grupos experimentais, sendo constituídos de três animais por grupo. Os grupos foram divididos de acordo com o tempo de fluidoterapia: G1 (sem fluidoterapia), G2 (uma hora de fluidoterapia antes da cisplatina), G3 (uma hora de fluidoterapia antes da cisplatina e uma hora após) e G4 (duas horas de fluidoterapia antes da cisplatina e uma após). Todos os animais receberam cisplatina na dose de 70 mg/m2, por via intravenosa, diluída em solução fisiológica 0,9%, e administrada por um período de 20 minutos. Os ciclos de quimioterapia foram realizados em intervalos de três semanas totalizando três ciclos. O ondansetron foi administrado na dose de 0,4 mg/kg, por via intravenosa, a cada 8 horas, no dia da quimioterapia e a seguir a cada 12 horas por dois dias, começando 30 minutos antes do início da quimioterapia. O methimazole foi administrado na dose de 40mg/kg, por via oral, 30 minutos antes da cisplatina e quatro horas após. Foram avaliados os parâmetros hematológicos, bioquímicos, urinários e dosagem de tiroxina e triiodotironina a cada sete dias até o término do experimento. Pelos resultados obtidos observou-se que este protocolo é eficaz e seguro quando os animais permanecem por um período de duas a três horas sob fluidoterapia, visto que não apresentaram alterações clínicas laboratoriais decorrentes do uso da quimioterapia...
The cisplatin is an antineoplasic agent used in veterinary oncology, being indicated to the adjuvant treatment of several neoplasms, however, its therapeutic effectiveness is, a lot of times, limited by its nephrotoxic and emetogenic effects. The objective of this study was evaluating a new chemotherapic protocol, using association of methimazole and ondansetron to the cisplatin, besides trying to minimize the time of saline diuresis. Twelve male dogs were divided in four experimental groups, being constituted of three animals by group. The groups were divided according to the time of saline diuresis: G1 (without saline diuresis), G2 (an hour of saline diuresis before the cisplatin), G3 (an hour of saline diuresis before the cisplatin and one hour after) and G4 (two hours of saline diuresis before the cisplatin and one after). All animals received cisplatin in the dose of 70 mg/m2, for intravenous road, diluted in physiologic solution 0,9%, and administered by a period of 20 minutes. The chemotherapy cycles were accomplished in intervals of three weeks with three cycles. Ondansetron was administered in the dose of 0,4 mg/kg, for intravenous road, at every 8 hours, in the day of the chemotherapy and to proceed every 12 hours for two days, beginning 30 minutes before the beginning of the chemotherapy. Methimazole was administered orally in the dose of 40mg/kg, 30 minutes before the cisplatin and four hours after. The hematological, biochemical, urinary parameters and dosage of tiroxin and triiodotironine were evaluated every seven days until the end of the experiment. It was observed that this protocol is effective and safe when the animals stay for a period of two or three hours under saline diuresis, because they didn't present clinical and laboratory alterations of the use of chemotherapy... (Complete abstract, access undermentioned eletronic address)
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Fonseca, Cláudia Sampaio. "Associação do methimazole e do ondansetron à quimioterapia com cisplatina em cães submetidos à quatro diferentes protocolos de fluidoterapia /." Jaboticabal : [s.n.], 2002. http://hdl.handle.net/11449/101164.
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Orientador: Carlos Roberto DaleckBanca: Júlio Carlos Canola
Banca: Newton Nunes
Banca: Cleuza Maria de Faria Rezende
Banca: Duvaldo Eurides
Resumo: A cisplatina é um agente antineoplásico utilizado em oncologia veterinária, sendo indicada no tratamento adjuvante de várias neoplasias, contudo, sua eficácia terapêutica é, muitas vezes, limitada por seu efeito nefrotóxico e emetogênico. Neste estudo, objetivou-se avaliar um novo protocolo quimioterápico, utilizando associação do methimazole e do ondansetron à cisplatina, além de tentar minimizar o tempo de fluidoterapia. Foram utilizados 12 cães, machos, divididos em quatro grupos experimentais, sendo constituídos de três animais por grupo. Os grupos foram divididos de acordo com o tempo de fluidoterapia: G1 (sem fluidoterapia), G2 (uma hora de fluidoterapia antes da cisplatina), G3 (uma hora de fluidoterapia antes da cisplatina e uma hora após) e G4 (duas horas de fluidoterapia antes da cisplatina e uma após). Todos os animais receberam cisplatina na dose de 70 mg/m2, por via intravenosa, diluída em solução fisiológica 0,9%, e administrada por um período de 20 minutos. Os ciclos de quimioterapia foram realizados em intervalos de três semanas totalizando três ciclos. O ondansetron foi administrado na dose de 0,4 mg/kg, por via intravenosa, a cada 8 horas, no dia da quimioterapia e a seguir a cada 12 horas por dois dias, começando 30 minutos antes do início da quimioterapia. O methimazole foi administrado na dose de 40mg/kg, por via oral, 30 minutos antes da cisplatina e quatro horas após. Foram avaliados os parâmetros hematológicos, bioquímicos, urinários e dosagem de tiroxina e triiodotironina a cada sete dias até o término do experimento. Pelos resultados obtidos observou-se que este protocolo é eficaz e seguro quando os animais permanecem por um período de duas a três horas sob fluidoterapia, visto que não apresentaram alterações clínicas laboratoriais decorrentes do uso da quimioterapia... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The cisplatin is an antineoplasic agent used in veterinary oncology, being indicated to the adjuvant treatment of several neoplasms, however, its therapeutic effectiveness is, a lot of times, limited by its nephrotoxic and emetogenic effects. The objective of this study was evaluating a new chemotherapic protocol, using association of methimazole and ondansetron to the cisplatin, besides trying to minimize the time of saline diuresis. Twelve male dogs were divided in four experimental groups, being constituted of three animals by group. The groups were divided according to the time of saline diuresis: G1 (without saline diuresis), G2 (an hour of saline diuresis before the cisplatin), G3 (an hour of saline diuresis before the cisplatin and one hour after) and G4 (two hours of saline diuresis before the cisplatin and one after). All animals received cisplatin in the dose of 70 mg/m2, for intravenous road, diluted in physiologic solution 0,9%, and administered by a period of 20 minutes. The chemotherapy cycles were accomplished in intervals of three weeks with three cycles. Ondansetron was administered in the dose of 0,4 mg/kg, for intravenous road, at every 8 hours, in the day of the chemotherapy and to proceed every 12 hours for two days, beginning 30 minutes before the beginning of the chemotherapy. Methimazole was administered orally in the dose of 40mg/kg, 30 minutes before the cisplatin and four hours after. The hematological, biochemical, urinary parameters and dosage of tiroxin and triiodotironine were evaluated every seven days until the end of the experiment. It was observed that this protocol is effective and safe when the animals stay for a period of two or three hours under saline diuresis, because they didn't present clinical and laboratory alterations of the use of chemotherapy... (Complete abstract, access undermentioned eletronic address)
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Books on the topic "Methimazol"
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Soto-Rivera, Carmen L., and Michael S. D. Agus. Endocrine Disorders in Pediatric Critical Care. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199918027.003.0016.
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This chapter focuses in pediatric endocrine disorders that can present acutely and warrant intensive care. Because most of the symptoms associated with endocrine diseases are nonspecific, a broad index of suspicion and knowledge of the details of hormonal regulation are essential for accurate diagnosis and timely management. The chapter includes important information on the pathophysiology, clinical manifestations, evaluation, and management of potentially life-threatening endocrine disorders, including diabetes insipidus, syndrome of inappropriate antidiuretic hormone secretion, acute primary and secondary adrenal insufficiency, disorders of calcium homeostatis, thyroid storm, and diabetic ketoacidosis. For treatment of these disorders, the authors discuss the use of vasopressin (aqueous pitressin), desmopressin, hydrocortisone, calcitonin, bisphosphonates, methimazole, iodide therapy, and insulin.
Book chapters on the topic "Methimazol"
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Bagnasco, M., D. Venuti, M. Caria, G. Pizzamo, O. Ferrini, and G. W. Canonica. "Methimazole, γ-”Interferon and Graves′ Disease." In Thyroid Autoimmunity, 445–47. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0945-1_76.
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Werner, M. C., J. H. Romaldini, N. Bromberg, M. T. A. Boesso, and R. S. Werner. "Adverse Reactions Related to Methimazole and Propylthiouracil Doses." In Thyroid Autoimmunity, 501–3. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0945-1_90.
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"Thiamazol (Methimazol)." In Checkliste Arzneimittel A–Z, edited by Detlev Schneider and Frank Richling. Stuttgart: Georg Thieme Verlag, 2013. http://dx.doi.org/10.1055/b-0034-82791.
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"Thiamazol (Methimazol) to Torasemid." In Checkliste Arzneimittel A - Z, edited by Schneider and Richling. Stuttgart: Georg Thieme Verlag, 2017. http://dx.doi.org/10.1055/b-0037-144512.
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"Langzeit-Methimazol-Behandlung der autonomiebedingten Altershyperthyreose versus Radioiodtherapie." In Schilddrüse 1997, 194–97. De Gruyter, 1998. http://dx.doi.org/10.1515/9783110807226-029.
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"Pharmakokinetik von Methimazol und seinem Metaboliten 3-Methyl-2-Thiohydantoin." In Schilddrüse 1993, 80–84. De Gruyter, 1994. http://dx.doi.org/10.1515/9783110883138-012.
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Furman, Brian L. "Methimazole." In xPharm: The Comprehensive Pharmacology Reference, 1–4. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.62148-8.
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Furman, B. L. "Methimazole ☆." In Reference Module in Biomedical Sciences. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-801238-3.98053-x.
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Schardein, James L., and Orest T. Macina. "Methimazole." In Human Developmental Toxicants, 105–10. CRC Press, 2006. http://dx.doi.org/10.1201/9781420006759-21.
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"Methimazole." In Human Developmental Toxicants, 105–10. Informa Healthcare, 2006. http://dx.doi.org/10.1201/9781420006759.ch21.
Full textConference papers on the topic "Methimazol"
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Amjad, M. A., N. Sharma, D. C. Kazmierski, and P. O. Ochieng. "Methimazole Induced Pancreatitis and Multiorgan Failure." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2936.
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Zaidi, Gulrukh, Rajkumar Dasgupta, and Ruth Minkin. "Methimazole Induced Agranulocytosis Complicated By A Retropharygeal Abscess." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5365.
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