Journal articles: 'Méthode de type hp'

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Lacoste-Dujardin, Camille. "Une ethnologue à Ravensbrück ou l'apport de la méthode dans le premier Ravensbrück de Germaine Tillion (1946)." Histoire@Politique 5, no. 2 (2008): 6. http://dx.doi.org/10.3917/hp.005.0006.

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Chow, Josephine S. F., Veronica Eugenia Gonzalez-Arce, Chun Wah Michael Tam, Ben Neville, and Alan McDougall. "HealthPathways implementation on type 2 diabetes." Journal of Integrated Care 27, no. 2 (April 15, 2019): 153–62. http://dx.doi.org/10.1108/jica-07-2018-0047.

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Purpose The purpose of this paper is to appraise the development, implementation and acceptance of HealthPathways (HP), specifically in Type 2 Diabetes Mellitus (T2DM), at different levels of the health system in a large metropolitan Local Health District in Australia. Design/methodology/approach This study used a programmatic approach and mixed methods including literature reviews, site visits, semi-structured interviews of stakeholders and General Practitioners (GPs), and surveys (GPs and patients) to better understand the development, implementation and acceptance of T2DM pathways. Findings Results from this study indicate that 63 percent (n=37) of all survey respondents use HP and nearly half (47 percent) use HP in caring for a patient with diabetes. More than 80 percent of the health professionals found HP a useful tool, which has improved the quality of care, keeps them informed and supports diagnostics process. The use of website has led to an improvement in referral quality (69 percent), has assisted in the provision of more healthcare in the community (87 percent) and made their job easier. Thematic analysis from stakeholder interviews (n=12) emphasizes the importance of established collaborations and the need for standardized tools with common priorities and transparency in processes. Practical implications This study has provided insight into the details of delivery of integrated healthcare using HP. It provides a preliminary analysis of the lessons learnt for the implementation of HP. Originality/value The results of this study will be ideally placed to inform future policy amendments in the area of integrated healthcare as well as serving as a guide on implementing HP in the future.

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Radtke, Paul K., and Lutz Schimansky-Geier. "A nonlinear HP-type complementary resistive switch." AIP Advances 6, no. 5 (May 2016): 055119. http://dx.doi.org/10.1063/1.4952755.

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Maetani, Tomoki, Hiroshi Shima, Yusuke Shiraishi, and Satoshi Marumo. "Case of summer-type hypersensitivity pneumonitis complicated with IgA nephropathy." BMJ Case Reports 12, no. 6 (June 2019): e228785. http://dx.doi.org/10.1136/bcr-2018-228785.

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Association between pulmonary disease and IgA nephropathy (IgAN) has been previously reported. However, no association has been reported between hypersensitivity pneumonitis (HP) and IgAN. Here, we report about a patient with no particular medical history, who experienced worsening dyspnoea in the course of 1 month, with ground-glass opacity on chest CT and no improvement after antibiotic therapy. The patient was diagnosed as having HP based on the history of antigen exposure, detection of Trichosporon asahii-specific antibodies and bronchoscopy findings. Concomitantly, findings of renal biopsy revealed the IgAN diagnosis. The patient underwent corticosteroid therapy, with good outcomes for both HP and IgAN. This is the first report in the literature to describe summer-type HP complicated with IgAN.

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Kelly, Clare B., Jeremy Y. Yu, Alicia J. Jenkins, Alison J. Nankervis, Kristian F. Hanssen, Satish K. Garg, James A. Scardo, et al. "Haptoglobin Phenotype Modulates Lipoprotein-Associated Risk for Preeclampsia in Women With Type 1 Diabetes." Journal of Clinical Endocrinology & Metabolism 104, no. 10 (June 20, 2019): 4743–55. http://dx.doi.org/10.1210/jc.2019-00723.

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Abstract Context The incidence of preeclampsia (PE) is increased in women with diabetes (∼20% vs ∼5% in the general population), and first trimester lipoprotein profiles are predictive. Haptoglobin (Hp), a protein with functional genetic polymorphisms, has antioxidant, anti-inflammatory, and angiogenic effects. Among people with diabetes, the Hp 2-2 phenotype is associated with cardiorenal disease. Objective To investigate whether Hp phenotype is associated with PE in type 1 diabetes mellitus (T1DM) and/or modulates lipoprotein-associated risks. Design and Setting Multicenter prospective study of T1DM pregnancy. Patients Pregnant women with T1DM (normal albuminuria, normotensive at enrolment, n = 47) studied at three visits, all preceding PE onset: 12.3 ± 1.9, 21.8 ± 1.5, and 31.5 ± 1.6 weeks’ gestation (mean ± SD). Main Outcome Measures Hp phenotype and lipoprotein profiles in women with (n = 23) vs without (n = 24) subsequent PE. Results Hp phenotype did not predict PE, but lipoprotein associations with subsequent PE were confined to women with Hp 2-2, in whom the following associations with PE were observed: increased low-density lipoprotein (LDL) cholesterol, LDL particle concentration, apolipoprotein B (APOB), triacylglycerol/high-density lipoprotein (HDL) cholesterol ratio, and APOB/apolipoprotein AI (APOA1) ratio; decreased HDL cholesterol, APOA1, large HDL particle concentration, and peripheral lipoprotein lipolysis (all P < 0.05). In women with one or two Hp-1 alleles, no such associations were observed. Conclusions In women with T1DM, although Hp phenotype did not predict PE risk, lipoprotein-related risks for PE were limited to those with the Hp 2-2 phenotype. Hp phenotype may modulate PE risk in diabetes.

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Hoque, Sanzana, Yuki Kondo, Nodoka Sakata, Yusei Yamada, Madoka Fukaura, Taishi Higashi, Keiichi Motoyama, et al. "Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells." International Journal of Molecular Sciences 21, no. 3 (January 30, 2020): 898. http://dx.doi.org/10.3390/ijms21030898.

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Niemann–Pick disease type C (NPC) is an autosomal recessive disorder characterized by abnormal accumulation of free cholesterol and sphingolipids in lysosomes. The iminosugar miglustat, which inhibits hexosylceramide synthesis, is used for NPC treatment, and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic oligosaccharide derivative, is being developed to treat NPC. Moreover, therapeutic potential of 2-hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was shown in NPC models, although its mechanism of action remains unclear. Here, we investigated the effects of HP-β-CD, HP-γ-CD, and their homolog 2-hydroxypropyl-α-cyclodextrin (HP-α-CD) on lipid accumulation in Npc1-null Chinese hamster ovary (CHO) cells compared with those of miglustat. HP-β-CD and HP-γ-CD, unlike HP-α-CD, reduced intracellular free cholesterol levels and normalized the lysosome changes in Npc1-null cells but not in wild-type CHO cells. In contrast, miglustat did not normalize intracellular free cholesterol accumulation or lysosome changes in Npc1-null cells. However, miglustat decreased the levels of hexosylceramide and tended to increase those of sphingomyelins in line with its action as a glucosylceramide synthase inhibitor in both Npc1-null and wild-type CHO cells. Interestingly, HP-β-CD and HP-γ-CD, unlike HP-α-CD, reduced sphingomyelins in Npc1-null, but not wild-type, cells. In conclusion, HP-β-CD and HP-γ-CD reduce the accumulation of sphingolipids, mainly sphingomyelins, and free cholesterol as well as lysosome changes in Npc1-null, but not in wild-type, CHO cells.

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Noda, Hiroto, Mitsuru Kaise, Ryuichi Wada, Eriko Koizumi, Kumiko Kirita, Kazutoshi Higuchi, Jun Omori, et al. "Characteristics of non-neoplastic epithelium that appears within gastric cancer with and without Helicobacter pylori eradication: A retrospective study." PLOS ONE 16, no. 3 (March 10, 2021): e0248333. http://dx.doi.org/10.1371/journal.pone.0248333.

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A non-neoplastic epithelium (NE) often appears in gastric cancer (GC). We explored the histological features of NE in comparison between HP-eradicated and HP-infected GCs. We enrolled 40 HP-eradicated and 40 HP-infected GCs matched by size, macroscopic and histological type. NE was classified into full gland type and surface type; the former was a non-neoplastic gland isolated within cancer, and the latter was NE on the surface of the cancer. Surface type was additionally divided into NE at the cancer margin (marginal surface type) and NE inside cancer (internal surface type). The primary endpoints were the frequency and the length ratio (the ratio to cancer length) of NE. The secondary endpoints were the relationships between NE and clinicopathological factors, including endoscopic findings of a gastritis-like appearance (GLA), reddish depressed lesion (RDL), and white nodular mucosa (WNM). The frequency and length ratio of the internal surface type in HP-eradicated GCs were significantly higher (82.5% vs 50%, P = 0.005) and larger (11.6 ± 10.6 vs 4.2 ± 9.9, P < 0.001) than those in HP-infected GCs, and the increase was more significant according to the passage of time since HP eradication. The frequency and length ratio of marginal surface type and full gland type were not significantly different between the two groups, but the coexistence of internal surface and full gland types was statistically significant (p < 0.001). The frequencies of GLA, RDLs, and WNM in HP-eradicated GCs were significantly higher than those in HP-infected GCs. GLA-positive GCs were covered more widely by internal surface type than GLA-negative GCs (13.3% vs. 6.6%, P = 0.003). Various types of NE were noted in gastric cancer, and the internal surface type of NE was shown to be significantly linked to HP-eradicated cancer and GLA.

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Yang, Xing-Tang, and Zhi-Jun Wang. "CD177 Expression and Inflammation Grade in Helicobacter pylori-Infected Wild-Type and CD177-/- C57BL/6 Mice." Analytical Cellular Pathology 2019 (April 4, 2019): 1–6. http://dx.doi.org/10.1155/2019/9506863.

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This study was undertaken to further investigate the CD177 expression in Helicobacter pylori- (Hp-) infected wild-type and CD177-/- C57BL/6 mice, which may be helpful to elucidate the relationship between CD177 and Hp-related gastritis. 20 WT mice were randomly assigned into the Hpss1 WT group (n=10) and Hp49503 WT group (n=10); 20 KO mice were randomly assigned into the Hpss1 KO group (n=10) and Hp49503 KO group (n=10). The remaining mice served as controls. Mice in the HpSS1 groups and Hp49503 groups were independently infected with corresponding strains. Results showed that the Hp colonization score was related to the grade of mucosal inflammation (P<0.05). The inflammation grade was comparable between the HpSS1 group and Hp49503 group as well as between the WT group and KO group. In addition, the Hp colonization score was related to the CD177 expression score (P<0.05). The CD177 expression in the Hp colonization group was higher than that in the non-Hp colonization group (P<0.05). CD177 expression was positively related to the inflammation grade (P<0.01). In conclusion, CD177 expression was similar between HP49503- and HPss1-infected WT C57BL/6 mice, and CD177 expression was undetectable in CD177-/- mice. CD177 expression in the gastric mucosa increases with the elevation of inflammation grade. In Hp-infected mice, the inflammation grade had no relationship with the type of Hp strain and the CD177 expression, but the mucosal inflammation score in Hp-infected mice was higher than that in non-Hp infected mice.

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Dalan, Rinkoo, and Goh Liuh Ling. "The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus." European Journal of Preventive Cardiology 25, no. 14 (May 25, 2018): 1502–19. http://dx.doi.org/10.1177/2047487318776829.

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Introduction and background Haptoglobin (Hp) is considered to be an antioxidant and protective against cardiovascular complications. Polymorphisms in the Hp gene interact with diabetes mellitus to affect the risk of vascular complications. Methods We review the updated literature about the protean role of Hp and Hp genotypes spanning genomics, molecular, translational and clinical studies. We searched Pubmed, SCOPUS and Google Scholar for all articles using the keywords: haptoglobin and/or haptoglobin polymorphism and diabetes. We review the diverse Hp genotypes, phenotypes and the impact on diabetes complications, including lessons from animal models and in vitro models. We describe the clinical studies on the associations of Hp genotypes with vascular complications in type 1 and type 2 diabetes comprehensively. We review the studies looking at vitamin E supplementation in a personalized manner in Hp2-2 diabetes individuals. Results and conclusion Hp genotypes have evolved as a result of deletions in the traditional Hp genes. The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. A preferential benefit of vitamin E and other antioxidants in the Hp2-2 genotype for cardiovascular complications in type 2 diabetes has been seen presumably secondary to interaction with high-density lipoprotein function. Hence, the Hp genotype can be used to personalize antioxidant therapeutics in diabetes patients. These results need to be corroborated in large, global, pragmatic, prospective, cardiovascular outcome trials in type 2 diabetes patients.

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Baertschi, SW, AS Cantrell, MT Kuhfeld, U. Lorenz, DB Boyd, and SR Jaskunas. "Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Degradation Products of Ceftazidime." Antiviral Chemistry and Chemotherapy 8, no. 4 (August 1997): 353–62. http://dx.doi.org/10.1177/095632029700800408.

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Previous work by Hafkemeyer et al. (1991) [ Nucleic Acids Research19: 4059–4065] indicated that a degradation product of ceftazidime, termed HP 0.35, was active against the RNase H activity of human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus (FIV) reverse transcriptase (RT) in vitro. Attempting to repeat these results, we isolated HP 0.35 from an aqueous degradation of ceftazidime and, after careful purification, we found HP 0.35 to be essentially inactive against both the polymerase and RNase H domains of HIV-1 RT (IC50 of >100 μg mL−1). During the investigation we discovered that polymeric degradation products of ceftazidime inhibited both the polymerase and, to a greater extent, the RNase H activities of HIV-1 RT in vitro (IC50 approximately 0.1 and 0.01 μg mL−1, respectively). Subjecting HP 0.35 to conditions under which it could polymerize induced inhibitory activity similar to that of the polymeric ceftazidime degradation products. It is proposed that the previously reported activity of HP 0.35 may have resulted from the presence of low levels of polymeric material either from incomplete purification or from polymerization of HP 0.35 during storage or in vitro testing.

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Alvarez, J., and M. Milman. "Hp continuity properties of Calderón-Zygmund-type operators." Journal of Mathematical Analysis and Applications 118, no. 1 (August 1986): 63–79. http://dx.doi.org/10.1016/0022-247x(86)90290-8.

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Ghio, Andrew J., Xinchao Wang, Robert Silbajoris, Michael D. Garrick, Claude A. Piantadosi, and Funmei Yang. "DMT1 expression is increased in the lungs of hypotransferrinemic mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 284, no. 6 (June 1, 2003): L938—L944. http://dx.doi.org/10.1152/ajplung.00225.2002.

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Despite a lack of transferrin, hypotransferrinemic (Hp) mice demonstrate an accumulation of iron in peripheral organs including the lungs. One potential candidate for such transferrin-independent uptake of iron is divalent metal transporter-1 (DMT1), an established iron transporter. We tested the hypothesis that increased concentrations of iron in the lungs of Hp mice are associated with elevations in DMT1 expression. With the use of inductively coupled plasma emission spectroscopy, measurements of nonheme iron confirmed significantly elevated concentrations in the lung tissue of Hp mice relative to the wild-type mice. Western blot analyses for the expression of two isoforms of DMT1 in the Hp mice relative to the wild-type animals demonstrated an elevation for the isoform that lacks an iron-responsive element (IRE) with significant decrements in the expression of +IRE DMT1. With the use of immunohistochemistry, −IRE DMT1 was localized to both airway epithelial cells and alveolar macrophages in wild-type mice. Staining appeared increased in both types of cells in the Hp mice. Elevated concentrations of both tissue nonheme iron and expression of −IRE DMT1 in the Hp mice were associated with increased quantities of −IRE mRNA. There was no difference between wild-type and homozygotic Hp mice in the amount of mRNA for DMT1 +IRE. We conclude that differences between Hp and wild-type mice in nonheme iron concentrations were accompanied by increases in the expression of −IRE DMT1. Increased expression of −IRE DMT1 in the lungs of the Hp mice could be responsible for elevated concentrations of the metal in these tissues.

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Marlink, Katie L., Kathy D. Bacon, Brett C. Sheppard, Hassan Ashktorab, Duane T. Smoot, Timothy L. Cover, Clifford W. Deveney, and Michael J. Rutten. "Effects ofHelicobacter pylorion intracellular Ca2+signaling in normal human gastric mucous epithelial cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 1 (July 2003): G163—G176. http://dx.doi.org/10.1152/ajpgi.00257.2002.

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In stomach, Helicobacter pylori ( Hp) adheres to gastric mucous epithelial cells (GMEC) and initiates several different signal transduction events. Alteration of intracellular Ca2+concentration ([Ca2+]i) is an important signaling mechanism in numerous bacteria-host model systems. Changes in [Ca2+]iinduced by Hp in normal human GMEC have not yet been described; therefore, we examined effects of Hp on [Ca2+]iin normal human GMEC and a nontransformed GMEC line (HFE-145). Cultured cells were grown on glass slides, porous filters, or 96-well plates and loaded with fura 2 or fluo 4. Hp wild-type strain 60190 and vacA–, cagA–, and picB–/cagE–isogenic mutants were incubated with cells. Changes in [Ca2+]iwere recorded with a fluorimeter or fluorescence plate reader. Wild-type Hp produced dose-dependent biphasic transient [Ca2+]ipeak and plateau changes in both cell lines. Hp vacA–isogenic mutant produced changes in [Ca2+]isimilar to those produced by wild type. Compared with wild type, cagA–and picB–/cagE–isogenic mutants produced lower peak changes and did not generate a plateau change. Preloading cultures with intracellular Ca2+chelator BAPTA blocked all Hp-induced [Ca2+]ichanges. Thapsigargin pretreatment of cultures to release Ca2+from internal stores reduced peak change. Extracellular Ca2+removal reduced plateau response. Hp-induced peak response was sensitive to G proteins and PLC inhibitors. Hp-induced plateau change was sensitive to G protein inhibitors, src kinases, and PLA2. These findings are the first to show that H. pylori alters [Ca2+]iin normal GMEC through a Ca2+release/influx mechanism that depends on expression of cagA and picB/cagE genes.

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Kim, H. O., S. M. Kim, and E. G. Kwon. "A note on a space Hp, a of holomorphic functions." Bulletin of the Australian Mathematical Society 35, no. 3 (June 1987): 471–79. http://dx.doi.org/10.1017/s0004972700013447.

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For 0 < p < ∞ and 0 ≤a; ≤ 1, we define a space Hp, a of holomorphic functions on the unit disc of the complex plane, for which Hp, 0 = H∞, the space of all bounded holomorphic functions, and Hp, 1 = Hp, the usual Hardy space. We introduce a weak type operator whose boundedness extends the well-known Hardy-Littlewood embedding theorem to Hp, a, give some results on the Taylor coefficients of the functions of Hp, a and show by an example that the inner factor cannot be divisible in Hp, a.

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Cuomo, Paola, Marina Papaianni, Clementina Sansone, Antonio Iannelli, Domenico Iannelli, Chiara Medaglia, Debora Paris, Andrea Motta, and Rosanna Capparelli. "An In Vitro Model to Investigate the Role of Helicobacter pylori in Type 2 Diabetes, Obesity, Alzheimer’s Disease and Cardiometabolic Disease." International Journal of Molecular Sciences 21, no. 21 (November 8, 2020): 8369. http://dx.doi.org/10.3390/ijms21218369.

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Helicobacter pylori (Hp) is a Gram-negative bacterium colonizing the human stomach. Nuclear Magnetic Resonance (NMR) analysis of intracellular human gastric carcinoma cells (MKN-28) incubated with the Hp cell filtrate (Hpcf) displays high levels of amino acids, including the branched chain amino acids (BCAA) isoleucine, leucine, and valine. Polymerase chain reaction (PCR) Array Technology shows upregulation of mammalian Target Of Rapamycin Complex 1 (mTORC1), inflammation, and mitochondrial dysfunction. The review of literature indicates that these traits are common to type 2 diabetes, obesity, Alzheimer’s diseases, and cardiometabolic disease. Here, we demonstrate how Hp may modulate these traits. Hp induces high levels of amino acids, which, in turn, activate mTORC1, which is the complex regulating the metabolism of the host. A high level of BCAA and upregulation of mTORC1 are, thus, directly regulated by Hp. Furthermore, Hp modulates inflammation, which is functional to the persistence of chronic infection and the asymptomatic state of the host. Finally, in order to induce autophagy and sustain bacterial colonization of gastric mucosa, the Hp toxin VacA localizes within mitochondria, causing fragmentation of these organelles, depletion of ATP, and oxidative stress. In conclusion, our in vitro disease model replicates the main traits common to the above four diseases and shows how Hp may potentially manipulate them.

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Bowers, Benjamin F. "Laboratory Evaluation of Mixture Type on Highly Modified Asphalt Mixtures in Virginia." Transportation Research Record: Journal of the Transportation Research Board 2672, no. 28 (September 9, 2018): 59–68. http://dx.doi.org/10.1177/0361198118792998.

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The work presented attempts to address reflective cracking of asphalt-surfaced pavements through binder modification with a highly polymer (HP)-modified asphalt binder. Nine asphalt mixtures ranging from fine dense-graded mixtures to stone matrix asphalt (SMA) mixtures were investigated with conventional polymer modified binders and HP binder. The dynamic modulus test, overlay test (OT), and semi-circular bend (SCB) test were used to evaluate the mixtures. In the cracking tests, HP mixtures outperformed the conventionally modified control mixtures for the same mixture type. For HP mixtures, in general, SMA mixtures performed better in the cracking test than dense-graded mixtures. One of the dense-graded mixtures having larger nominal maximum aggregate size (NMAS) performed better than the mixture with a smaller NMAS, whereas the other having a larger NMAS was not significantly different in crack testing. Further, a discussion on the calculation of bulk specific gravity and percent air voids in a cut OT and SCB specimen using saturated surface dry or vacuum sealing methods is presented.

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McCulloch, David K., and Ernest L. Mazzaferri. "Comprehensive Management of Type 2 Diabetes." Hospital Practice 35, no. 9 (September 15, 2000): 33–50. http://dx.doi.org/10.3810/hp.2000.09.212.

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Xiao, Shuqi, Yaosheng Chen, Liangliang Wang, Jintao Gao, Delin Mo, Zuyong He, and Xiaohong Liu. "Simultaneous Detection and Differentiation of Highly Virulent and Classical Chinese-Type Isolation of PRRSV by Real-Time RT-PCR." Journal of Immunology Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/809656.

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Porcine reproductive and respiratory syndrome (PRRS) is a leading disease in pig industry worldwide and can result in serious economic losses each year. The PRRS epidemic situation in China has been very complicated since the unprecedented large-scale highly pathogenic PRRS (HP-PRRS) outbreaks in 2006. And now the HP-PRRS virus (HP-PRRSV) and classical North American type PRRSV strains have coexisted in China. Rapid differential detection of the two strains of PRRSV is very important for effective PRRS control. The real-time RT-PCR for simultaneous detection and differentiation of HP-PRRSV and PRRSV by using both SYBR Green and TaqMan probes was developed and validated. Both assays can be used for rapid detection and strain-specific identification of HP-PRRSV and PRRSV. However, the TaqMan probe method had the highest detection rate whereas the conventional RT-PCR was the lowest. The real-time RT-PCR developed based on SYBR Green and TaqMan probe could be used for simultaneous detection and differentiation of HP-PRRSV and PRRSV in China, which will benefit much the PRRS control and research.

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Riecken, Jan F., Gunter Heymann, Wilfried Hermes, Ute Ch Rodewald, Rolf-Dieter Hoffmann, Hubert Huppertz, and Rainer Pöttgen. "High-pressure / High-temperature Studies on the Stannides RENiSn (RE = Ce, Pr, Nd, Sm) and REPdSn (RE = La, Pr, Nd)." Zeitschrift für Naturforschung B 63, no. 6 (June 1, 2008): 695–706. http://dx.doi.org/10.1515/znb-2008-0616.

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The normal-pressure (NP) orthorhombic TiNiSi-type (space group Pnma) stannides RENiSn (RE = Ce, Pr, Nd, Sm) and REPdSn (RE = La, Pr, Nd) were transformed into the corresponding hexagonal ZrNiAl-type (space group P6̄2m) high-pressure (HP) modifications under multianvil high-pressure (7.5 - 11.5 GPa) high-temperature (1100 - 1200 °C) conditions. The structures of NP-CeNiSn, HPPrNiSn, NP-NdNiSn, HP-LaPdSn, HP-PrPdSn, and HP-NdPdSn were refined from single crystal X-ray diffractometer data. Structural data for HP-SmNiSn were obtained from a Rietveld powder refinement. The high-pressure phase transition significantly changes the rare earth coordination, i. e. 4 RE + 6 Ni(Pd) + 6 Sn atoms for the NP-phases and 6 RE + 5 Ni(Pd) + 6 Sn atoms for the HPphases. Susceptibility measurements of HP-PrPdSn and HP-NdPdSn reveal paramagnetic behavior with experimental magnetic moments of 3.61(1) μB/Pr atom and 3.66(1) μB/Nd atom, respectively. Low-temperature susceptibility and specific heat data point to inhomogeneous magnetism and spinglass behavior, respectively.

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Vaishnav, Bhumika T., Sameer R. Shaikh, Arvind A. Bamanikar, Arjun Lal Kakrani, and Rahul R. Tambile. "Diagnostic Upper Gastrointestinal Endoscopy and Prevalence of Helicobacter Pylori Infection in Dyspeptic Type 2 Diabetes Mellitus Patients." Journal of Digestive Endoscopy 09, no. 02 (April 2018): 053–60. http://dx.doi.org/10.4103/jde.jde_10_18.

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ABSTRACT Introduction: Multisystem involvement is a norm in Type 2 diabetes mellitus (T2DM). Dyspepsia is a common gastrointestinal (GI) tract symptom in people with diabetes. We aimed to study the esophageal, gastric, and duodenal mucosal changes; presence of Helicobacter pylori (HP) infection; and its significance in dyspeptic diabetes patients. Materials and Methods: A prospective observational study done on 287 patients (147 patient with diabetes and 140 nondiabetic controls) with dyspepsia of more than 6 months duration. All patients underwent upper GI endoscopy and evaluation for HP infection. Gross and histopathological examination (HPE) features of biopsies from the esophagus, stomach (fundus, body, and antrum), and duodenum were analyzed and rapid urease test as well as HPE was done for HP detection. Statistical analysis was done and results were expressed as mean ± standard deviation. P < 0.05 was considered to be statistically significant. Results: Average age for dyspeptic T2DM patients was 56.0 ± 8.44 years. Total 67.35% diabetes patients were addicted to tobacco. Epigastric pain and heartburn were the most common symptoms. Antral gastritis was the most common gross (75.08%) and HPE (70.38%) finding in patients with diabetes. In all, 44.21% patients with diabetes tested positive for HP infection, and there was a statistically significant association of HP with T2DM when compared with nondiabetics (P < 0.00001). However, HP infection did not correlate significantly with either glycosylated hemoglobin (HbA1c) or duration of T2DM. Conclusion: Antral gastritis was a common finding in dyspeptic diabetic patients. HP infection although associated with T2DM dyspeptic patients, was not associated with either uncontrolled sugar levels or duration of diabetes.

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Dahan, Inbal, Evgeny Farber, Nadia Thauho, Nakhoul Nakhoul, Adi Francis, Mohamad Awawde, Andrew P. Levy, Daniel B. Kim-Shapiro, Swati Basu, and Farid Nakhoul. "Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients." Journal of Diabetes Research 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/613860.

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Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascular tone. We therefore set out to test the hypothesis that the Hp polymorphism may be a determinant of developing elevated s-PAP specifically in the DM state due to a decreased bioavailability of NO. To test our hypothesis we Hp typed and performed transthoracic echocardiography on a series of HD patients and stratified them into elevated and normal s-PAP groups and then evaluated whether there was a significant association between the Hp type, elevated s-PAP, and decreased NO bioavailability as defined by low plasma nitrite. We found a statistically significant interaction between the Hp type and DM on the prevalence of elevated s-PAP and lower mean nitrite levels with the combination of elevated s-PAP and low nitrite levels being significantly more prevalent in Hp 2-2 DM individuals. We conclude that the Hp 2 type is associated with elevated s-PAP levels and low plasma nitrite levels in HD patients specifically in the DM state.

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Wu, Huiqun, Huan Wu, Lili Shi, Xinlu Yuan, Ying Yin, Mingjie Yuan, Yushan Zhou, Qianwen Hu, Kui Jiang, and Jiancheng Dong. "The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic Patients: A Meta-Analysis." Journal of Diabetes Research 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2195059.

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Aims/Introduction. To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).Methods. A comprehensive literature review was performed for eligible studies. After inclusion and exclusion selection as well as quality assessment, those studies meeting quality standards were included. In this study, diabetic patients with retinopathy were selected as the case group and those ones without DR were treated as the control group. The recessive model, allele model, additive model, heterozygote model, and homozygote model were utilized to investigate the association of three Hp gene variants and DR. Subgroup analysis on different severity of DR including nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) was also conducted.Results. Six trials from different regions were finally included. A total of 1145 subjects containing 564 T2DM patients with retinopathy were included. The recessive model, allele model, additive model, and homozygote model results showed that Hp gene variants were not associated with DR, NPDR, and PDR. However, the heterozygote model indicated the association of Hp gene variants with DR.Conclusions. No association was found between the Hp gene variants and PDR and NPDR. More studies are required to verify these findings.

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Karges, W., K. Jostarndt, S. Maier, A. Flemming, M. Weitz, A. Wissmann, B. Feldmann, H. Dralle, P. Wagner, and BO Boehm. "Multiple endocrine neoplasia type 1 (MEN1) gene mutations in a subset of patients with sporadic and familial primary hyperparathyroidism target the coding sequence but spare the promoter region." Journal of Endocrinology 166, no. 1 (July 1, 2000): 1–9. http://dx.doi.org/10.1677/joe.0.1660001.

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Germ line mutations of the multiple endocrine neoplasia type 1 (MEN1) tumour suppressor gene cause MEN1, a rare familial tumour syndrome associated with parathyroid hyperplasia, adenoma and hyperparathyroidism (HP). Here we investigated the role of the MEN1 gene in isolated sporadic and familial HP. Using RT-PCR single-strand conformational polymorphism screening, somatic (but not germ line) mutations of the MEN1 coding sequence were identified in 6 of 31 (19.3%) adenomas from patients with sporadic primary HP, but none in patients (n=16) with secondary HP due to chronic renal failure. MEN1 mutations were accompanied by a loss of heterozygosity (LOH) for the MEN1 locus on chromosome 11q13 in the adenomas as detected by microsatellite analysis. No DNA sequence divergence within the 5' region of the MEN1 gene, containing the putative MEN1 promoter, was detectable in HP adenomas. Clinical characteristics were not different in HP patients with or without MEN1 mutation. Heterozygous MEN1 gene polymorphisms were identified in 9.6% and 25% of patients with primary and secondary HP respectively. In a large kindred with familial isolated familial HP, MEN1 germ line mutation 249 del4 and LOH was associated with the HP phenotype and a predisposition to non-endocrine malignancies. We suggest that the bi-allelic somatic loss of MEN1 wild-type gene expression is involved in the pathogenesis of a clinically yet undefined subset of sporadic primary HP adenomas. MEN1 genotyping may further help define the familial hyperparathyroidism-MEN1 disease complex, but it seems dispensable in sporadic primary HP.

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Xuefu, Liu, Cai Zhengdong, and Tan Huisong. "Photometry of an active Algol-type binary HP Aur." Astrophysics and Space Science 154, no. 1 (1989): 1–6. http://dx.doi.org/10.1007/bf00643772.

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Benick, Jan, Armin Richter, Ralph Muller, Hubert Hauser, Frank Feldmann, Patricia Krenckel, Stephan Riepe, et al. "High-Efficiency n-Type HP mc Silicon Solar Cells." IEEE Journal of Photovoltaics 7, no. 5 (September 2017): 1171–75. http://dx.doi.org/10.1109/jphotov.2017.2714139.

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Taillandier, D., X. Bigard, D. Desplanches, D. Attaix, C. Y. Guezennec, and M. Arnal. "Role of protein intake on protein synthesis and fiber distribution in the unweighted soleus muscle." Journal of Applied Physiology 75, no. 3 (September 1, 1993): 1226–32. http://dx.doi.org/10.1152/jappl.1993.75.3.1226.

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Protein turnover in skeletal muscle is very sensitive to protein intake. To examine whether protein intake is able to affect protein synthesis in the atrophied soleus muscle, the effects of a high-protein (30%, HP) and a medium-protein (15%, MP) diet were studied in rats after 21 days of hindlimb unweighting. Three weeks of unweighting induced a sharp decrease in food intake (30%). The fractional rate of protein synthesis (ks) was determined in vivo in the slow-twitch soleus muscle by use of a flooding-dose method. With respect to pair-fed animals, a significant reduction in ks occurred (33%) in MP non-weight-bearing rats, whereas it was of lesser magnitude and not significant in HP rats. In the atrophied soleus muscle of non-weight-bearing MP rats, a large decrease (42%) in type I fiber distribution was accompanied by an increase in intermediate and type IIa fibers. By contrast, a higher percentage of type I fiber was maintained with the HP diet. However, the HP diet had no beneficial effect in preventing the decrease in either type I fiber cross-sectional area (65%) or the average decrease in absolute myofibrillar and mitochondrial volumes (69 and 52%, respectively). These results demonstrate that an HP intake did not prevent soleus muscle atrophy but may sustain protein synthesis and partly preserve fiber type distribution without affecting the ultrastructural composition of fibers. Because the circulating level of free 3,5,3'-triiodothyronine was reduced by 14% with the HP diet, this effect on fiber type distribution, and possibly protein synthesis, may involve thyroid hormones.

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Torres, Carlos R. G., Cristiane S. Souza, Alessandra B. Borges, Maria Filomena R. L. Huhtala, and Taciana M. F. Caneppele. "Influence of Concentration and Activation on Hydrogen Peroxide Diffusion through Dental TissuesIn Vitro." Scientific World Journal 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/193241.

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This study evaluated the effect of physical and chemical activation on the diffusion time of different concentrations of hydrogen peroxide (HP) bleaching agents through enamel and dentin. One hundred and twenty bovine cylindrical specimens were divided into six groups (n=20): 20% HP ; 20% HP with light activation; 20% HP with manganese gluconate; 35% HP; 35% HP with light activation; and 35% HP with manganese gluconate. The specimens were fixed over transparent epoxy wells with internal cavities to simulate a pulpal chamber. This chamber was filled with an enzymatic reagent to simulate pulpal fluid. The bleaching gels were applied on enamel surface and the image of the pulpal fluid was captured by a video camera to monitor the time of peroxide penetration in each specimen. ANOVA analysis showed that concentration and type of activation of bleaching gel significantly influenced the diffusion time of HP (P<0.05). 35% HP showed the lowest diffusion times compared to the groups with 20% HP gel. The light activation of HP decreased significantly the diffusion time compared to chemical activation. The highest diffusion time was obtained with 20% HP chemically activated. The diffusion time of HP was dependent on activation and concentration of HP. The higher concentration of HP diffused through dental tissues more quickly.

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Kim, Yong-Cheol. "Weak Type Estimates of the Maximal Quasiradial Bochner-Riesz Operator On Certain Hardy Spaces." Canadian Mathematical Bulletin 46, no. 2 (June 1, 2003): 191–203. http://dx.doi.org/10.4153/cmb-2003-020-9.

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AbstractLet be the dilation group in generated by the infinitesimal generator M where At = exp(M log t), and let be a At-homogeneous distance function defined on . For , we define the maximal quasiradial Bochner-Riesz operator of index δ > 0 byIf At = tI and is a smooth convex hypersurface of finite type, then we prove in an extremely easy way that is well defined on Hp() when δ = n(1/p − 1/2) − 1/2 and 0 n(1/p − 1/2) − 1/2 and 0 < p < 1.

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KINOSHITA, MASAKI. "Comparative study of membrane type mechanical lung CAPI O X SX HP and mela HP Excellane Prime." Japanese journal of extra-corporeal technology 26, no. 2 (1999): 27–30. http://dx.doi.org/10.7130/hokkaidoshakai.26.2_27.

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Bawin-Legros, Bernadette. "Du type d’explication possible au choix d’une méthode réelle." Sociologie et sociétés 14, no. 1 (February 18, 2008): 53–63. http://dx.doi.org/10.7202/006766ar.

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RÉSUMÉ Dans le grand débat méthodologique qui oppose méthodes quantitatives et qualitatives, il semble que les chercheurs en sciences sociales aient souvent négligé l'interrogation fondamentale qui est celle du type d'explication que l'on cherche sur un objet bien défini. Cet article ne vise rien d'autre qu'à montrer, à travers le parcours d'une recherche empirique sur la mobilité sociale des femmes, les problèmes théoriques, méthodologiques et épistémologiques rencontrés et causés par l'absence de construction d'un objet de recherche (les femmes), ou d'un empirisme sans principes (application telle quelle de modèles construits pour les trajectoires professionnelles des hommes). Il aboutit cependant à proposer l'élaboration d'un nouveau discours sociologique, plus proche des acteurs sociaux et de leur histoire immédiate, par l'utilisation des récits de vie.

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Bu, Shangquan, and Christian Le Merdy. "Hp-Maximal Regularity and Operator Valued Multipliers on Hardy Spaces." Canadian Journal of Mathematics 59, no. 6 (December 1, 2007): 1207–22. http://dx.doi.org/10.4153/cjm-2007-051-5.

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AbstractWe consider maximal regularity in the Hp sense for the Cauchy problem u′(t) + Au(t) = f(t) (t ∈ ℝ), where A is a closed operator on a Banach space X and f is an X-valued function defined on ℝ. We prove that if X is an AUMD Banach space, then A satisfies Hp-maximal regularity if and only if A is Rademacher sectorial of type < . Moreover we find an operator A with Hp-maximal regularity that does not have the classical Lp-maximal regularity. We prove a related Mikhlin type theorem for operator valued Fourier multipliers on Hardy spaces Hp(ℝ X), in the case when X is an AUMD Banach space.

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Alexander, Baimy. "EFFECT OF AIR FILTER TYPE ON THE PERFORMANCE OF THE 110 CC INJECTION MOTORCYCLE." Scientific Journal of Mechanical Engineering Kinematika 5, no. 2 (December 28, 2020): 138–49. http://dx.doi.org/10.20527/sjmekinematika.v5i2.180.

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Saringan udara adalah salah satu komponen yang sangat penting pada motor bakar yang berfungsi untuk melakukan penyaringan udara sebelum masuk kedalam ruang bakar. Hambatan aliran yang disebabkan oleh penyaring udara sangat berpengaruh terhadap daya dan torsi mesin serta berpengaruh juga terhadap konsumsi bahan bakar. Hasil penelitian menunjukkan bahwa penggunaan berbagai jenis saringan udara terjadi perubahan daya dan torsi pada mesin sepeda motor injeksi, saringan udara standar 7,349 (HP) dan 7,429 (N.m) diputaran 6829 RPM, saringan udara busa 7,254 (HP) dan 7,648 (N.m) diputaran 6862 RPM, saringan udara Ferrox 7,382 (HP) dan 7,737 (N.m) diputaran 6794 RPM, tanpa saringan 7,268 (HP) dan 7,737 (N.m) diputaran 6794 RPM. Peningkatan daya dan torsi terlihat pada saringan udara Ferrox sedangkan penurunan daya terjadi pada tanpa saringan udara. Pengaruh terhadap konsumsi bahan bakar dalam 20 ml diputaran 3000 RPM, untuk saringan udara standar 1 menit 57 detik, saringan udara busa 2 menit 13 detik, saringan udara Ferrox 1 menit 47 detik, dan tanpa saringan udara 1 menit 22 detik, waktu tercepat dalam konsumsi bahan bakar pada perobaan tanpa saringan udara 1 menit 22 detik sedangkan waktu terlama pada saringan udara busa 2 menit 13 detik.

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Lv, Ning, Jinxu Lv, Mingyan Sun, Wenhui Lv, and Qizhan Xiao. "Design and Implementation of Matryoshka-type Neutron Spectrometer." Health Physics 120, no. 2 (February 2021): 171–76. http://dx.doi.org/10.1097/hp.0000000000001297.

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Takeoka, Yoshiki, Phani Paladugu, James D. Kang, and Shuichi Mizuno. "Augmented Chondroitin Sulfate Proteoglycan Has Therapeutic Potential for Intervertebral Disc Degeneration by Stimulating Anabolic Turnover in Bovine Nucleus Pulposus Cells under Changes in Hydrostatic Pressure." International Journal of Molecular Sciences 22, no. 11 (June 2, 2021): 6015. http://dx.doi.org/10.3390/ijms22116015.

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Nucleus pulposus (NP) cells are exposed to changes in hydrostatic pressure (HP) and osmotic pressure within the intervertebral disc. We focused on main disc matrix components, chondroitin sulfate proteoglycan (CSPG) and hyaluronan (HA) to elucidate the capability of augmented CSPG to enhance the anabolism of bovine NP (bNP) cells under repetitive changes in HP at high osmolality. Aggrecan expression with CSPG in the absence of HP was significantly upregulated compared to the no-material control (phosphate buffer saline) under no HP at 3 days, and aggrecan expression with CSPG under HP was significantly higher than the control with HA under HP at 12 days. Collagen type I expression under no HP was significantly lower with CSPG than in controls at 3 days. Although matrix metalloproteinase 13 expression under HP was downregulated compared to no HP, it was significantly greater with HA than the control and CSPG, even under HP. Immunohistology revealed the involvement of mechanoreceptor of transient receptor potential vanilloid-4 activation under HP, suggesting an HP transduction mechanism. Addition of CSPG had anabolic and anti-fibrotic effects on bNP cells during the early culture period under no HP; furthermore, it showed synergy with dynamic HP to increase bNP-cell anabolism at later time points.

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CHOBOT, AGATA, KATARZYNA BĄK-DRABIK, ELIZA SKAŁA-ZAMOROWSKA, AGNIESZKA KRZYWICKA, JAROSŁAW KWIECIEŃ, and JOANNA POLAŃSKA. "Helicobacter pylori Infection in Type 1 Diabetes Children and Adolescents Using 13C Urea Breath Test." Polish Journal of Microbiology 63, no. 1 (2014): 63–67. http://dx.doi.org/10.33073/pjm-2014-009.

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There is a 10-30% prevalence of HP infection in the general pediatric population in Poland. This study aimed to determine its prevalence in T1DM children in Upper Silesia, Poland and estimate its influence on metabolic control of patients. We studied 149 (82 female) children with T1DM (duration > 12 months, mean HbA1c) and 298 (164 female) age-matched controls. In all cases height and weight z-scores and Cole's index were assessed. In T1DM patients additionally glycated hemoglobin A1c and T1DM duration were analyzed. Presence of HP infection was determined using 13C-isotope-labeled urea breath test (UBT) (fasting and 30 min after ingestion 75 mg of 13C urea). HP infection was present in 17 (11.4%) T1DM patients and in 49 (16.4%) controls (p > 0.05). T1DM patients presented higher values of anthropometric parameters than healthy controls (weight SDS 0.25[-0.46 divided by 0.84] vs. -0.25 [-1.06 divided by 0.26], height SDS 0.09 [-0.60 divided by 0.69] vs. -0.31[-1.17 divided by 0.48] and Cole's index 103% [93 divided by 111%] vs. 97% [86 divided by 106%]; for all p < 0001). Within both groups--T1DM children and controls--no differences regarding sex, age and any of the anthropometric parameters were determined. T1DM duration and HbA1c showed no relation to prevalence of HP infection. Prevalence of HP infection in pediatric T1DM patients is similar to that of healthy peers and shows no relation to glycemic control.

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Bayrak, Nevzat Aykut, and Burcu Volkan. "Helicobacter pylori Infection in Children with Concurrent Celiac Disease and Type 1 Diabetes Mellitus." Digestive Diseases 39, no. 5 (2021): 444–50. http://dx.doi.org/10.1159/000514276.

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Objectives: Data regarding Helicobacter pylori (Hp) infection frequency in concurrent celiac disease (CD) and type 1 diabetes mellitus (T1DM) (CD + T1DM) are anecdotal. This study aimed to evaluate the association between Hp and concomitant CD + T1DM in children. Methods: In this 2-center, case-control study, children who underwent esophago-gastro-duodenoscopy (EGD) were studied. CD diagnosis was established by favorable histology and serology. Hp infection was confirmed by both histology and the rapid urease test. Patients were divided into 3 groups as CD only (CDo), CD + T1DM, and non-CD children who underwent endoscopy as controls. Results: Among the 1,431 EGDs performed, 783 cases were eligible. Overall, 215 cases had CDo (mean age: 9.12 ± 4.18 years, 58.1% girls), 63 cases had CD + T1DM (mean age: 9.29 ± 4.46 years, 50.8% girls), and 505 cases were controls (mean age: 9.69 ± 4.52 years, 56.6% girls). Hp infection rate was significantly lower in CD + T1DM group (controls: 49.7% vs. CDo: 32.1% vs. CD + T1DM: 20.6%, p < 0.01). After adjustment for age, gender, and socioeconomic status, the Hp infection rate was still significantly low (adjusted odds ratio [aOR]: 1.57, 95% confidence interval (CI): 1.35–1.83, p < 0.01). A difference in Hp infection rate between controls and CDo group (aOR: 1.43, 95% CI: 1.09–2.12, p < 0.05), and between CDo and CD + T1DM (aOR: 0.89, 95% CI: 0.65–1.54, p < 0.05) group was significant. The severity of duodenal lesions and the presence of Hp infection were not correlated in all celiac children (r: 0.113, p > 0.05). Conclusion: The frequency of Hp infection was significantly lower in CD + T1DM children, compared to the CDo group and the controls.

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Pol, Jaydeep N., Medha P. Kulkarni, Rakhi V. Jagadale, and Alka V. Gosavi. "Pancreatic heterotopia: An overview of a lesion often mimicking neuroendocrine tumour." Indian Journal of Pathology and Oncology 8, no. 3 (August 15, 2021): 397–402. http://dx.doi.org/10.18231/j.ijpo.2021.076.

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Pancreatic tissue that has no direct or vascular connection to the main body of the pancreas constitutes ectopic pancreas or heterotopic pancreas (HP). Majority are located in the upper gastrointestinal tract (GIT). HP may be mistaken for neoplasms like neuroendocrine tumour (NET) and adenocarcinoma on endoscopy as well as on histopathology. We report six cases of HP along with review of literature; three of them were misdiagnosed as NET. To the best of our knowledge, this is the first case series of HP from India, rest being case reports. Histopathological features of six cases of HP were analyzed. Variables examined were clinical presentation, age at diagnosis, location, histopathologic type and immunohistochemical profile. Two cases each were seen in duodenum and Meckel’s diverticulum while one case each was seen in stomach and an atretic segment of ileum, a site never reported previously. There were five males and one female with age ranging from one day to 48 years. Patients with gastric and duodenal HP were symptomatic. On histopathology, four cases were intramuscular and two were submucosal. Four cases were of Type I and two cases were of type II. HP should be considered in the differential diagnosis of submucosal upper GI lesions. Awareness, high degree of suspicion and thorough histopathological examination are necessary to arrive at a correct diagnosis. Immunohistochemistry for chromogranin and synaptophysin is useful for confirming the islets especially on small endoscopic biopsies. HP must be considered in the differential diagnosis of submucosal upper GI lesions. Knowledge about this entity, high degree of suspicion and thorough histopathological examination help in arriving at a correct diagnosis and excluding mimics.

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Tephnadze, George. "On the maximal operators of Riesz logarithmic means of Vilenkin-Fourier series." Studia Scientiarum Mathematicarum Hungarica 51, no. 1 (March 1, 2014): 105–20. http://dx.doi.org/10.1556/sscmath.51.2014.1.1268.

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Beuchler, Sven, and Martin Purrucker. "Schwarz Type Solvers for -FEM Discretizations of Mixed Problems." Computational Methods in Applied Mathematics 12, no. 4 (2012): 369–90. http://dx.doi.org/10.2478/cmam-2012-0030.

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AbstractThis paper investigates the discretization of mixed variational formulation as, e.g., the Stokes problem by means of the hp-version of the finite element method. The system of linear algebraic equations is solved by the preconditioned Bramble-Pasciak conjugate gradient method. The development of an efficient preconditioner requires three ingredients, a preconditioner related to the components of the velocity modes, a preconditioner for the Schur complement related to the components of the pressure modes and a discrezation by a stable finite element pair which satisfies the discrete inf-sup-condition. The last condition is also important in order to obtain a stable discretization scheme. The preconditioner for the velocity modes is adapted from fast $hp$-FEM preconditioners for the potential equation. Moreover, we will prove that the preconditioner for the Schur complement can be chosen as a diagonal matrix if the pressure is discretized by discontinuous finite elements. We will prove that the system of linear algebraic equations can be solved in almost optimal complexity. This yields quasioptimal hp-FEM solvers for the Stokes problems and the linear elasticity problems. The latter are robust with respect to the contraction ratio ν. The efficiency of the presented solver is shown in several numerical examples.

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Yang, Sung-Eun, Won-Ki Min, Hyosoon Park, Sail Chun, Joon Nah, and Jin Q. Kim. "Distribution of haptoglobin phenotypes in a Korean population, using the semi-automated PhastSystem." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 37, no. 2 (March 1, 2000): 205–9. http://dx.doi.org/10.1258/0004563001899014.

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We have established a new phenotyping method for haptoglobin, based on sodium dodecyl sulphate-polyacrylamide gel electrophoresis using the PhastSystem (Pharmacia Biotech, Uppsala, Sweden), followed by immunoblotting for detection. We measured haptoglobin concentrations and determined the haptoglobin phenotypes of 316 healthy Koreans using this method: 31 (9·8%) were of Hp 1-1 type, 140 (44·3%) of Hp 2-1 type and 145 (45·9%) of Hp 2-2 type. The haptoglobin allele frequencies were calculated to be 0·32 for Hp1 and 0·68 for Hp2. We were able to visualize up to 12 bands from the human Hp 2-2 polymeric series, with molecular weights in the range 171·9 x 103 to 802·2 x 103. The reference range of serum haptoglobin concentrations obtained by the IFCC (International Federation of Clinical Chemistry) standard method was 0·27 - 2·14 g/L. The serum haptoglobin concentration in Koreans was similar to that of Caucasians, but the Hp1 allele frequency was lower in Koreans. Our method could be used in clinical laboratories as a simple and practical method of haptoglobin phenotyping. In addition, the Hp 2-2 polymeric series could be used as high molecular weight standards.

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Pavlíček, Zdeněk, and Rüdiger Ettrich. "Chaperone-Like Activity of Human Haptoglobin: Similarity with α-Crystallin." Collection of Czechoslovak Chemical Communications 64, no. 4 (1999): 717–25. http://dx.doi.org/10.1135/cccc19990717.

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Human haptoglobin (Hp) has been shown to have chaperone-like activity in preventing thermally induced aggregation of catalase and γ-crystallin. No differences in the chaperone- like behaviour of genetic types Hp 1-1 and a mixture of types Hp 2-1 and Hp 2-2 (i.e. Hp II) were found. Haptoglobin not only suppresses heat-induced aggregation of proteins but also prevents γ-crystallin from aggregation by oxidative stress. In addition, haptoglobin also provides protection against glycation-induced inactivation of catalase by glyceraldehyde. Chaperone-like activity of haptoglobin decreases in the course of its glycation. Refolding studies have shown that Hp exhibits its chaperone-like activity predominantly on the unfolding and not on the refolding pathway. Although Hp and α-crystallin have no sequence similarities, it seems that their chaperone-like activities are of the same type.

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Tanaka, Takuro, Kosuke Matsubara, Atsushi Fukuda, and Satoshi Kobayashi. "ESTIMATION OF Hp(3) TO THE EYE LENS OF INTERVENTIONAL RADIOLOGISTS—RELATION BETWEEN THE EYE LENS DOSE AND RADIOLOGIST’S HEIGHT." Radiation Protection Dosimetry 187, no. 4 (October 12, 2019): 409–17. http://dx.doi.org/10.1093/rpd/ncz181.

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Abstract The aim of the study was to estimate occupational radiation dose to the eye lens of radiologists and the dose reduction ratio of lead glasses during interventional radiology. Three interventional radiologists monitored Hp(3) using small-type optically stimulated luminescence dosemeters attached to the left inside and outside of the lead glasses with 0.07-mmPb [Hp(3)eye]. Hp(10) and Hp(0.07) were monitored, respectively, by attaching the personal dosemeter to the lead neck collar above the lead apron. The median Hp(3)eye with lead glasses and the median dose reduction ratio of lead glasses for the three radiologists were 8.02 mSv/y and 57.7%, respectively. The median Hp(3)eye without lead glasses [Hp(3)eye-w/o] for the three radiologists was 18.6 mSv/y, but Hp(3)eye-w/o for one of the radiologists was 24.1 mSv/y. Monitoring occupational radiation dose to the eye lens is important because interventional radiologists are at risk of exceeding the new dose limit.

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Kong, Lingbo, Christopher J. Doona, Peter Setlow, and Yong-qing Li. "Monitoring Rates and Heterogeneity of High-Pressure Germination of Bacillus Spores by Phase-Contrast Microscopy of Individual Spores." Applied and Environmental Microbiology 80, no. 1 (October 25, 2013): 345–53. http://dx.doi.org/10.1128/aem.03043-13.

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ABSTRACTGermination ofBacillusspores with a high pressure (HP) of ∼150 MPa is via activation of spores' germinant receptors (GRs). The HP germination of multiple individualBacillus subtilisspores in a diamond anvil cell (DAC) was monitored with phase-contrast microscopy. Major conclusions were that (i) >95% of wild-type spores germinated in 40 min in a DAC at ∼150 MPa and 37°C but individual spores' germination kinetics were heterogeneous; (ii) individual spores' HP germination kinetic parameters were similar to those of nutrient-triggered germination with a variable lag time (Tlag) prior to a period of the rapid release (ΔTrelease) of the spores' dipicolinic acid in a 1:1 chelate with Ca2+(CaDPA); (iii) spore germination at 50 MPa had longer averageTlagvalues than that at ∼150 MPa, but the ΔTreleasevalues at the two pressures were identical and HPs of <10 MPa did not induce germination; (iv)B. subtilisspores that lacked the cortex-lytic enzyme CwlJ and that were germinated with an HP of 150 MPa exhibited average ΔTreleasevalues ∼15-fold longer than those for wild-type spores, but the two types of spores exhibited similar averageTlagvalues; and (v) the germination of wild-type spores given a ≥30-s 140-MPa HP pulse followed by a constant pressure of 1 MPa was the same as that of spores exposed to a constant pressure of 140 MPa that was continued for ≥35 min; (vi) however, after short 150-MPa HP pulses and incubation at 0.1 MPa (ambient pressure), spore germination stopped 5 to 10 min after the HP was released. These results suggest that an HP of ∼150 MPa for ≤30 s is sufficient to fully activate spores' GRs, which remain activated at 1 MPa but can deactivate at ambient pressure.

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Nakhoul, Farid M., Rachel Miller-Lotan, Hoda Awad, Rabea Asleh, Kheir Jad, Nakhoul Nakhoul, Roy Asaf, Niroz Abu-Saleh, and Andrew P. Levy. "Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus." American Journal of Physiology-Renal Physiology 296, no. 4 (April 2009): F830—F838. http://dx.doi.org/10.1152/ajprenal.90655.2008.

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Polymorphic loci regulating oxidative stress are potential susceptibility genes for diabetic nephropathy (DN). Haptoglobin (Hp) is an antioxidant protein which serves to protect against oxidative stress induced by extracorpuscular hemoglobin. There are two alleles at the Hp locus, 1 and 2. The Hp 1 protein is a superior antioxidant to the Hp 2 protein. The Hp 2 allele has been associated with increased prevalence of DN and appears to be associated with a more rapid progression to end-stage renal disease. We sought to recapitulate this association between Hp genotype and DN in mice genetically modified at the Hp locus. We assessed morphometric, histologic, and functional parameters involved in the development and progression of DN in mice with diabetes mellitus (DM) with either the Hp 2-2 or Hp 1-1 genotype. Morphometric analysis demonstrated that glomerular and proximal tubular hypertrophy were significantly increased in Hp 2-2 DM mice. Histological analysis demonstrated that Hp 2-2 DM mice had significantly more collagen type IV, smooth muscle actin, and increased renal iron deposition. Studies of renal function demonstrated creatinine clearance time and albuminuria were increased in Hp 2-2 DM mice. Vitamin E provided significant protection against the development of functional and histological features characteristic of DN to Hp 2-2 DM but not to Hp 1-1 DM mice. These studies serve to strengthen the association between the Hp 2-2 genotype and diabetic renal disease and suggest a pharmacogenomic interaction may exist between the Hp genotype and vitamin E.

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Kang, S., Y. Hwang, H. Lee, S. Jeong, J. Choi, Y. Jo, S. Han, J. Kim, and J. Han. "Helicobacter pylori infection as an independent prognostic factor for locally advanced gastric cancer with curative resection." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 4562. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4562.

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4562 Background: A few studies reported the association between helicobacter pylori (HP) infection and better overall survival (OS) in resected gastric cancer patients (pts). Methods: We investigated the HP infection status and its association with clinicopathologic characteristics in 210 locally advanced gastric cancer patients (stage IB: 18, II: 61, IIIA: 62, IIIB: 31, IV: 38) who underwent adjuvant chemotherapy (CTX) after curative resection (≥D2 dissection). HP infection status in hematoxlin and eosin stained peritumoral tissue was graded according to the updated Sydney System and categorized as HP(-) (normal or mild infection) and HP(+) (moderate or marked infection) (Am J Surg Pathol 20:1161, 1996). Twenty-two pts received 5-FU, doxorubicin (DOX) CTX (5- FU 500 mg/m2 weekly for 36 wks, DOX 40 mg/m2 q 3 weeks x 12) with or without OK432, while 188 pts underwent 5-FU, mitomycin-C (MMC), and polysaccharide-K (PSK) CTX (5-FU 500 mg/m2 weekly for 24 wks, MMC 8 mg/m2 q 6 wks x 4, PSK 3 g/day for 16 wks) (Br J Cancer 84:186, 2001, Hepatogastroenterol 54:290, 2007). Results: The median follow-up duration of survivors was 125 (107–155) months. HP (-) was significantly correlated with Bormann type IV, larger tumor size (>5.5cm),and stage IIIB. In univariate analysis, patients with HP(-) (104 pts) demonstrated significantly poor 10-year OS compared with those with HP (+) (106 pts) (15.9% vs. 87.7%, p<0.0001). HP(-) was associated with poor outcome in all stages except stage IB (p=0.075). In multivariate analysis, HP(-) was the most significant independent prognostic factor of poor OS (hazard ratio 9.646, 95% CI 5.407–17.206, p<0.0001) followed by advanced stage (p=0.032), Bormann type IV (p=0.037) and old age (p=0.015). Conclusions: HP infection status seems to have strong prognostic significance in locally advanced gastric cancer. HP (-) pts may need intensified adjuvant treatment and careful follow-up. No significant financial relationships to disclose.

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Xu, Ke Jun, Yong Qi Wang, Yi Rui Xia, and Ming Ming Jia. "The Stress Calculating and Analysis of the Second HP Turbine Disc of a Certain Type of Aeroengine." Applied Mechanics and Materials 331 (July 2013): 176–80. http://dx.doi.org/10.4028/www.scientific.net/amm.331.176.

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This paper takes the 2nd HP turbine disc of an aeroengine as research object, construct its finite element model in software-Patran. According to the work environment of 2nd HP turbine disc, the boundary conditions of stress field analysis and temperature field analysis are confirmed. Based on the finite element theory of thermal analysis and structure analysis, we use finite element software-Nastran to analyze centrifugal stress and thermal stress. Numerical calculation method was used to fit the data and finally we got the thermal elastic stress field. According to the computed results, the life assessment points of disc were confirmed. The static strength of 2nd HP turbine disc was tested based on the EGD-3 criterion. All the work established the foundation for subsequent life analysis.

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Garcia Caraballo, Sonia C., Tine M. Comhair, Cornelis H. C. Dejong, Wouter H. Lamers, and S. Eleonore Köhler. "A high-protein diet is anti-steatotic and has no pro-inflammatory side effects in dyslipidaemic APOE2 knock-in mice." British Journal of Nutrition 112, no. 8 (August 27, 2014): 1251–65. http://dx.doi.org/10.1017/s0007114514001986.

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High-protein (HP) diets are effective anti-steatotic treatment options for patients with non-alcoholic fatty liver disease, but whether these diets also decrease steatosis in hyperlipidaemic conditions is not known. The aim of the present study was to determine the effects of a HP diet on hepatic steatosis and inflammation in hyperlipidaemic mice. Hyperlipidaemic male and female APOE2 knock-in (APOE2ki) mice were fed a semi-synthetic low-protein (LP) or HP diet in combination with a low-fat diet or a high-fat diet for 3 weeks. The HP diets reduced hepatic fat and cholesterol concentrations to 40–55 % of those induced by the corresponding LP diets and attenuated hepatic inflammation mildly. The VLDL-associated plasma cholesterol concentrations decreased to 60–80 %, but those of TAG increased 3–4-fold. APOE2-mediated restriction of fat import into the liver did not modify the effects of a HP diet previously observed in wild-type mice. Female APOE2ki mice exhibited a higher expression of lipogenic, cholesterol-synthesising, inflammatory and cell-stress genes than wild-type female or male APOE2ki mice, but a similar response to HP diets. Low Apob expression and unchanged plasma APOB100 concentrations suggest that HP diets increase the plasma concentrations of TAG by slowing their clearance. The decrease in plasma leptin and hepatic fat and glycogen concentrations and the increase in fatty acid-oxidising gene and phosphoenolpyruvate carboxykinase 1 protein expression suggest a HP diet-mediated increase in mitochondrial metabolism. In conclusion, a HP diet reduces hepatic lipid content in dyslipidaemic mice and lowers the activation status of inflammatory cells in the liver.

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Sacco, Melanie A., Ken Howes, Lorraine P. Smith, and Venugopal K. Nair. "Assessing the Roles of Endogenous Retrovirus EAV-HP in Avian Leukosis Virus Subgroup J Emergence and Tolerance." Journal of Virology 78, no. 19 (October 1, 2004): 10525–35. http://dx.doi.org/10.1128/jvi.78.19.10525-10535.2004.

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ABSTRACT Avian leukosis virus (ALV) subgroup J is thought to have emerged through a recombination event between an unknown exogenous ALV and the endogenous retrovirus elements designated EAV-HP. All EAV-HP elements identified to date in the chicken genome show large deletions, including that of the entire pol gene. Here we report the identification of four segregating chicken EAV-HP proviruses with complete pol genes, one of which shows exceptionally high sequence identity and a close phylogenetic relationship with ALV-J with respect to the env gene. Embryonic expression of EAV-HP env has been suggested as a factor associated with immunological tolerance induction in a proportion of ALV-J-infected meat-type chickens. In support of this, env gene transcripts expressed from two of the four newly identified EAV-HP proviruses were demonstrated in chicken embryos. However, when ALV-J-infected outbred meat-type chickens were assessed, the presence of intact EAV-HP proviruses failed to directly correlate with ALV-J tolerance. This association was further examined using F2 progeny of two inbred lines of layer chicken that differed in EAV-HP status and immunological responses to ALV-J. Immunological tolerance developed in a small proportion of F2 progeny birds, reflecting the expected phenotypic ratio for inheritance of a double-recessive genotype; however, the status of tolerance did not show any direct correlation with the presence of the intact EAV-HP sequence. Nevertheless, identification of an intact chicken EAV-HP locus showing a uniquely close relationship to the ALV-J prototype clone HPRS-103 in the env region provides the strongest evidence of its contribution to the emergence of ALV-J by recombination.

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Xia, Shijia. "Hypersensitivity Pneumonitis: Perspective in Diagnosis and Pathology." E3S Web of Conferences 185 (2020): 03002. http://dx.doi.org/10.1051/e3sconf/202018503002.

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Hypersensitivity pneumonitis (HP) is the excessive immune response in the lung parenchyma (alveoli, terminal bronchiole, interstitium), resulting from repeated exposure to a variety of antigens. From the clinical point of view, HP can be divided into acute, subacute, or chronic forms. Only few of the exposed individuals develop HP, but workers in environments contaminated by organic dust are at a higher risk. The pathogenesis of HP is complex and still under investigation. Previous research suggests that both type III and IV hypersensitivity reactions are involved. The main treatment is the removal of antigen. Therefore, research of causative agents and pathogenesis is of outstanding importance not only for early diagnosis but also the better treatment of HP.

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Georgoulis, Emmanuil H. "Inverse-type estimates on $hp$-finite element spaces and applications." Mathematics of Computation 77, no. 261 (January 1, 2008): 201–19. http://dx.doi.org/10.1090/s0025-5718-07-02068-6.

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Journal articles on the topic 'Méthode de type hp'

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