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1

Ghoreishi, Zahra Sadat, Mojtaba Azimian, Javad Alaghband Rad, et al. "Analysis of Connected Speech in Persian Aphasic Patients and its Relationship With Type and Severity of Aphasia." Function and Disability Journal 15, no. 3 (2021): 141–50. http://dx.doi.org/10.32598/fdj.4.14.

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Background and Objectives: There are several tests to determine the type and severity of aphasia, but they take a long time to administer when assessing aphasic patients. In recent years, the analysis of spontaneous speech has gained great attention because it is important to diagnose and follow post-treatment improvement in aphasic patients. This study was done to assess some parameters of connected speech in aphasic patients. In addition, the correlation between connected speech parameters and the type and severity of aphasia was measured. Methods: We compared the connected speech parameters
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2

Ortiz, Genaro Gabriel, Héctor González-Usigli, Erick R. Nava-Escobar, et al. "Primary Progressive Aphasias: Diagnosis and Treatment." Brain Sciences 15, no. 3 (2025): 245. https://doi.org/10.3390/brainsci15030245.

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Background and Objective: Primary Progressive Aphasias (PPAs) are rare neurodegenerative disorders classified within frontotemporal lobar degeneration (FTLD) and typically manifest between 45 and 70 years of age. In Mexico—and many other countries—reliable epidemiological data are lacking; however, estimates suggest that PPA accounts for 0.5–2.5% of neurodegenerative disease cases in Memory Clinics, with an incidence of approximately 1 per 100,000 and an average survival of 8 years. This review aims to provide clinicians with an overview of PPA’s epidemiology, clinical features, and classifica
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3

Ruangsuk, Atchaphan, and Supaporn Chinchai. "The The development and psychometric properties of the Chiang Mai Aphasia Screening Test for stroke." Journal of Associated Medical Sciences 57, no. 3 (2024): 75–82. http://dx.doi.org/10.12982/jams.2024.049.

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Background: The aphasia screening test detects language and speech impairments, clarifying individuals’ language and speech abilities before administering a standardized aphasia diagnosis test. Objective: This study aimed to develop and validate an aphasia screening test for suspected cerebrovascular accident (CVA) patients with communication difficulties. Materials and methods: The study underwent two phases: developing and assessing psychometric properties. Five experts established content validity across receptive language, expressive language, reading, and writing. The Chiang Mai Aphasia S
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Devido-Santos, Michele, Rubens José Gagliardi, and Ana Paula Machado Goyano Mac-Kay. "Language disorders and brain lesion topography in aphasics after stroke." Arquivos de Neuro-Psiquiatria 70, no. 2 (2012): 129–33. http://dx.doi.org/10.1590/s0004-282x2012000200011.

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Aphasia is a language disorder associated with focal brain lesions. Although the topographic definition of the language area has been widely accepted, there is not necessarily any direct correlation between the lesion site and the manifested symptoms. Objective: To analyze aspects of language in aphasics in relation to lesion topography. Methods: A prospective, descriptive study of qualitative nature was conducted on 31 individuals, aged older than 15 years, with at least three years of schooling, and a confirmed diagnosis of stroke. Language assessment was carried out using the Montreal Toulo
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5

Siudak, Anna. "Gradualny sposób badania mowy pacjentów dorosłych z afazją." Poznańskie Studia Polonistyczne. Seria Językoznawcza 29, no. 1 (2022): 211–20. http://dx.doi.org/10.14746/pspsj.2022.29.1.13.

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This article is a voice in a streamlined discussion on methods for diagnosing adult patients with aphasia. The variety of aphasic symptoms and the complexity of the clinical picture of patients after neurological incidents often make it impossible to conduct an examination with standardised, well-known methods [see Siudak 2017]. The signals of reluctance towards the methods of examination sent by patients are uttered expressis verbis by people who have overcome aphasia: we need a conversation, not an examination. How then, do we turn diagnosis into a meeting? How can we determine the level of
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6

Nikitha, M., H. S. Darshan, B. P. Abhishek, and S. P. Goswami. "Clinical Profiling of a Bilingual Client with Anomic Aphasia." Annals of Neurosciences 27, no. 2 (2020): 75–82. http://dx.doi.org/10.1177/0972753120927518.

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Background: Aphasia is an acquired condition affecting auditory comprehension, verbal expression, reading, writing and word-finding abilities along with sensory-motor impairments. Anomia refers to difficulty in word retrieval or naming which is seen irrespective of the type of aphasia. However, if a patient shows word-finding difficulty, in specific, a diagnosis of Anomic aphasia is made. There are variations within anomic aphasia on which the management and recovery depend. The article provides one such case report. Purpose: Speech and language profiling in anomic aphasia, specific treatment
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7

Silveira, Gabriela, and Letícia Lessa Mansur. "Analysis of prototypical narratives produced by aphasic individuals and cognitively healthy subjects." Dementia & Neuropsychologia 9, no. 3 (2015): 279–84. http://dx.doi.org/10.1590/1980-57642015dn93000011.

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Aphasia can globally or selectively affect comprehension and production of verbal and written language. Discourse analysis can aid language assessment and diagnosis. Objective: [1] To explore narratives that produce a number of valid indicators for diagnosing aphasia in speakers of Brazilian Portuguese. [2] To analyze the macrostructural aspects of the discourse of normal individuals. [3] To analyze the macrostructural aspects of the discourse of aphasic individuals. Methods: The macrostructural aspects of three narratives produced by aphasic individuals and cognitively healthy subjects were a
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8

Zarei, Mahsa, Reza Nilipour, Mohsen Shati, et al. "Assessment of Aphasia in Iranian Patients Suffering from Frontotemporal Dementia." Iranian Journal of Psychiatry and Clinical Psychology 26, no. 4 (2021): 490–501. http://dx.doi.org/10.32598/ijpcp.26.3.3006.2.

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Objectives: Frontotemporal Dementia (FTD) is an uncommon type of dementia. The hallmark feature of FTD is the presentation with aphasia or behavioral changes which vary in different FTD subtypes. In this study, we propose a quantitative aphasia test as an additive diagnostic tool for differentiation of FTD subtypes. Methods: The applied study was conducted on 20 patients with FTD (13 men and 7 women) aged 58-78 years (Mean age=63±0.8 years) referred to dementia clinic of Rasul Akram Hospital in Tehran, Iran. Based on clinical diagnosis, patients were divided into three groups of behavioral var
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9

Strand, Edythe A. "Corticobasal Ganglionic Degeneration and Progressive Supranuclear Palsy: Clinical and Speech-Language Characteristics." Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders 20, no. 2 (2010): 45–49. http://dx.doi.org/10.1044/nnsld20.2.45.

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Abstract Purpose: The purpose of this article is to present a brief description of the neuroanatomical correlates, pathophysiology, and clinical presentation of corticobasal ganglionic degeneration, (often referred to as corticobasal degeneration, or CBD) and progressive supranuclear palsy (PSP). Methods: Descriptions of the clinical characteristics of the two degenerative syndromes are presented, including a discussion of the similarities and differences. The speech and language disorders associated with each are described, including progressive aphasia, progressive non-fluent aphasia (PNFA),
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10

Azimian, Mojtaba, Morteza Farazi, Reza Nilipour, et al. "Investigating the Effectiveness of Neuropsychological Rehabilitation on Stroke Patients." Iranian Rehabilitation Journal 22, no. 04 (2024): 595–604. http://dx.doi.org/10.32598/irj.22.4.1528.3.

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Objectives: This study aimed to investigate neuropsychological rehabilitation’s effectiveness on stroke patients’ cognitive status. Methods: This quasi-experimental study examined 22 adults with ischemic stroke of the left hemisphere (with an average age of 64.31 years) before and after the intervention. The patients had fluent aphasia (10 people) and non-fluent aphasia (12 people), along with cognitive disorders such as memory or attention disorder. Medical examination and para-clinical diagnosis of magnetic resonance imaging (MRI) with different causes, along with the Persian diagnostic apha
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11

Mousavi, Seyyedeh Zohreh, Reyhaneh Jafari, Saman Maroufizadeh, Mohammad Moez Shahramnia, Mahsa Pourmohammadi, and Nahid Jalilehvand. "Translation, Validity, and Reliability of the Persian Version of Aphasia Rapid Test for Acute Stroke." Function and Disability Journal 3, no. 1 (2020): 101–10. http://dx.doi.org/10.32598/fdj.3.15.

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Background & Objectives: Aphasia is an acquired language disorder that affects daily communication and quality of life. Early diagnosis and the treatment of aphasia are important. In this regard, one of the screening tests is the Aphasia Rapid Test (ART). This study aimed to investigate the validity and reliability of this test and extend the use of ART in the acute phase for patients with aphasia. Methods: The original version of ART was translated to Persian and 100 acute stroke patients were evaluated by ART. Besides, all the patients were assessed again after eight days by two independ
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12

Kong, Anthony Pak-Hin, and Adam Reres. "Proposing a quick, objective, comprehensive analysis of impaired spoken discourse in post-stroke aphasia." Clinical Archives of Communication Disorders 6, no. 3 (2021): 172–86. http://dx.doi.org/10.21849/cacd.2021.00626.

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Purpose: Aphasia is an acquired language disorder, most commonly caused by a stroke, that adversely affects one’s ability to understand, speak, read, and write. Diagnosis of aphasia is typically done through administration of standardized aphasia batteries, many of which lack a detailed and adequate evaluation of spoken discourse. The aim of this paper was to propose a quick, objective, and comprehensive analytic system that addressed the micro- and macro-linguistic aspects of oral narratives in persons with aphasia (PWA).Methods: Using a subgroup of unimpaired native speakers of English from
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13

Battista, Petronilla, Eleonora Catricalà, Marco Piccininni, et al. "Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties." Dementia and Geriatric Cognitive Disorders 46, no. 3-4 (2018): 243–52. http://dx.doi.org/10.1159/000492632.

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Background: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients. Methods: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC). Results: The SAND battery showed good internal consistency and good convergent and divergent validity. receiver operating characteristic analysis revealed an area under the curve of 0.9
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14

Ramasubbu, Rajamannar, and Sidney H. Kennedy. "Factors Complicating the Diagnosis of Depression in Cerebrovascular Disease, Part Ii — Neurological Deficits and Various Assessment Methods*." Canadian Journal of Psychiatry 39, no. 10 (1994): 601–7. http://dx.doi.org/10.1177/070674379403901004.

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Neurological deficits associated with cerebrovascular disease such as aphasia, dementia, anosognosia and aprosodia may impair the ability to express or experience depressive symptoms. Identification of depression in the absence of verbal report on subjective mood state is a difficult task. The value of various diagnostic methods including depressive rating scales, standard psychiatric interviews and biological variables in the diagnosis of depression in cerebrovascular disease is considered. This review concludes by focusing on the deficiencies of existing approaches in the diagnostic assessme
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15

Shcherbakova, Maria M. "Differential clinical signs of aphasia syndrome in acute and residual recovery periods. Directions of neurorehabilitation of patients with aphasia syndrome depending on the recovery period." Consilium Medicum 24, no. 12 (2023): 888–92. http://dx.doi.org/10.26442/20751753.2022.12.201952.

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Background. Speech and cognitive disorders of vascular genesis account for a significant percentage of the existing consequences of local disorders of cerebral circulation. Approximately 2140% of stroke patients suffer from persistent aphasia, which gradually worsens the quality of life and rehabilitation results.
 Aim. Improving the quality of neurorehabilitation of patients who have suffered a brain stroke.
 Materials and methods. The analysis of differential clinical signs of aphasia syndrome in patients of neuro-intensive care and vascular neurological departments was carried out
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16

Litvinenko, Igor V., Кristina A. Kolmakova, Аndrey Yu Emelin, and Vladimir Yu Lobzin. "Primary progressive aphasias: clinical and genetic heterogeneity and diagnostic difficulties." Annals of Clinical and Experimental Neurology 15, no. 4 (2021): 66–77. http://dx.doi.org/10.54101/acen.2021.4.7.

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This systematic review describes primary progressive aphasia (PPA) variants and includes the authors' own clinical observations. Over 20 genes have now been identified, with mutations that are directly involved in the development of the behavioural variant of frontotemporal dementia, as well as other forms of PPA. Pathomorphological markers of Alzheimer's disease were identified in 76% of cases of logopenic PPA, while signs of frontotemporal dementia associated with TDP-43 were identified in 80% of cases of the semantic variant, and those associated with TDP-43/tau were identified in 64% of ca
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17

Lacey, Elizabeth H., Laura M. Skipper-Kallal, Shihui Xing, Mackenzie E. Fama, and Peter E. Turkeltaub. "Mapping Common Aphasia Assessments to Underlying Cognitive Processes and Their Neural Substrates." Neurorehabilitation and Neural Repair 31, no. 5 (2017): 442–50. http://dx.doi.org/10.1177/1545968316688797.

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Background. Understanding the relationships between clinical tests, the processes they measure, and the brain networks underlying them, is critical in order for clinicians to move beyond aphasia syndrome classification toward specification of individual language process impairments. Objective. To understand the cognitive, language, and neuroanatomical factors underlying scores of commonly used aphasia tests. Methods. Twenty-five behavioral tests were administered to a group of 38 chronic left hemisphere stroke survivors and a high-resolution magnetic resonance image was obtained. Test scores w
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18

Singh, Tarun D., Joseph R. Duffy, Edythe A. Strand, Mary M. Machulda, Jennifer L. Whitwell, and Keith A. Josephs. "Neuropsychiatric Symptoms in Primary Progressive Aphasia and Apraxia of Speech." Dementia and Geriatric Cognitive Disorders 39, no. 3-4 (2015): 228–38. http://dx.doi.org/10.1159/000369062.

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Aim: To conduct a prospective analysis of the neuropsychiatric symptoms (NPS) across the three categories of primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS), compare the prevalence and nature of the symptoms, and look at which symptoms could be helpful to better differentiate these PPA and PAOS categories. Methods: A total of 106 consecutive patients with a diagnosis of semantic variant (n = 13), logopenic variant (n = 37), agrammatic variant (n = 15) or PAOS (n = 41) were included in this prospective study. The NPS were measured by the Neuropsychiatric Inventory Que
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19

Ulugut Erkoyun, Hulya, Sven J. van der Lee, Bas Nijmeijer, et al. "The Right Temporal Variant of Frontotemporal Dementia Is Not Genetically Sporadic: A Case Series." Journal of Alzheimer's Disease 79, no. 3 (2021): 1195–201. http://dx.doi.org/10.3233/jad-201191.

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Background: Right temporal variant frontotemporal dementia (rtvFTD) has been generally considered as a right sided variant of semantic variant primary progressive aphasia (svPPA), which is a genetically sporadic disorder. Recently, we have shown that rtvFTD has a unique clinical syndrome compared to svPPA and behavioral variant frontotemporal dementia. Objective: We challenge the assumption that rtvFTD is a sporadic, non-familial variant of FTD by identifying potential autosomal dominant inheritance and related genes in rtvFTD. Methods: We collected all subjects with a diagnosis of FTD or prim
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20

Kotsiubinskaya, Yu V., V. V. Vasilev, A. V. Kazakov, I. K. Stulov, and V. A. Mikhailov. "Atypical Structure of Broca's Area in a Patient with Primary Progressive Atrophy Syndrome at the Onset of Alzheimer's Disease." Personalized Psychiatry and Neurology 4, no. 1 (2024): 32–40. http://dx.doi.org/10.52667/10.52667/2712-9179-2024-4-1-2-17-9179-2024-4-1-32-40.

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This article presents a clinical case of Alzheimer’s disease with a debut as primary progressive aphasia syndrome. Insufficient use of routine magnetic resonance imaging in this case in the diagnosis of neurodegenerative diseases and the advantage of such additional neuroimaging methods as positron emission tomography, functional magnetic resonance imaging with a scale assessment of atrophic changes. Additional neuroimaging techniques have been shown to significantly improve the early detection of pathological changes in brain structures and to reveal the location of functional areas involved
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21

Nekrasova, N. O., S. Yu Rudenko, and L. V. Tykhonova. "Post-Stroke Aphasia in the Context of Modern Views on the Neurophysiology of Speech Function." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 5 (2021): 28–37. http://dx.doi.org/10.26693/jmbs06.05.028.

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The purpose of the study is to highlight the clinical experience of specialists from various countries, clinics and neurological specialties, in order to form an up-to-date review of the speech function neurophysiology, as well as the features of pathology, diagnosis and treatment of aphasia, as one of the most disabling symptoms accompanying ischemic stroke. Results. The speech function does not only limit communication options between doctor and patient, but it is also an important factor that makes it difficult to collect anamnesis and interpret the results of a neurological examination. In
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Brito-Marques, Paulo Roberto de, Roberto José Vieira-Mello, Luciano Montenegro, and Maria de Fátima Vasco Aragão. "Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review." Dementia & Neuropsychologia 5, no. 2 (2011): 135–41. http://dx.doi.org/10.1590/s1980-57642011dn05020013.

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Abstract Objective: To investigate progressive non-fluent aphasia and histopathologically-proven corticobasal degeneration. Methods: We evaluated symptoms, signs, neuropsychological deficits, and radiology data longitudinally, in a patient with autopsy-proven corticobasal degeneration and correlated these observations directly to the neuroanatomic distribution of the disease. Results: At presentation, a specific pattern of cognitive impairment was evident with an extreme extrapyramidal motor abnormality. Follow-up examination revealed persistent impairment of praxis and executive functioning,
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Shinagawa, Shunichiro, Joseree Ann Catindig, Nikolas R. Block, Bruce L. Miller, and Katherine P. Rankin. "When a Little Knowledge Can Be Dangerous: False-Positive Diagnosis of Behavioral Variant Frontotemporal Dementia among Community Clinicians." Dementia and Geriatric Cognitive Disorders 41, no. 1-2 (2016): 99–108. http://dx.doi.org/10.1159/000438454.

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Background: Accurate diagnosis of behavioral variant frontotemporal dementia (bvFTD) is important as patients' behavioral symptoms have profound implications for their families and communities. Since the diagnosis of bvFTD derives from behavioral features, accurate identification of patients can be difficult for non-specialists. Concrete rates of diagnostic accuracy among non-specialists are unavailable. Methods: To examine the accuracy of community clinicians' diagnoses of bvFTD and to identify patient characteristics leading to misdiagnosis, we reviewed the charts and referral letters of 3,5
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Moral-Rubio, Carlos, Paloma Balugo, Adela Fraile-Pereda, et al. "Application of Machine Learning to Electroencephalography for the Diagnosis of Primary Progressive Aphasia: A Pilot Study." Brain Sciences 11, no. 10 (2021): 1262. http://dx.doi.org/10.3390/brainsci11101262.

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Background. Primary progressive aphasia (PPA) is a neurodegenerative syndrome in which diagnosis is usually challenging. Biomarkers are needed for diagnosis and monitoring. In this study, we aimed to evaluate Electroencephalography (EEG) as a biomarker for the diagnosis of PPA. Methods. We conducted a cross-sectional study with 40 PPA patients categorized as non-fluent, semantic, and logopenic variants, and 20 controls. Resting-state EEG with 32 channels was acquired and preprocessed using several procedures (quantitative EEG, wavelet transformation, autoencoders, and graph theory analysis). S
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Senaha, Mirna Lie Hosogi, Paulo Caramelli, Sonia M. D. Brucki, et al. "Primary progressive aphasia: Classification of variants in 100 consecutive Brazilian cases." Dementia & Neuropsychologia 7, no. 1 (2013): 110–21. http://dx.doi.org/10.1590/s1980-57642013dn70100017.

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ABSTRACT Primary progressive aphasia (PPA) is a neurodegenerative clinical syndrome characterized primarily by progressive language impairment. Recently, consensus diagnostic criteria were published for the diagnosis and classification of variants of PPA. The currently recognized variants are nonfluent/agrammatic (PPA-G), logopenic (PPA-L) and semantic (PPA-S). Objective: To analyze the demographic data and the clinical classification of 100 PPA cases. Methods: Data from 100 PPA patients who were consecutively evaluated between 1999 and 2012 were analyzed. The patients underwent neurological,
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Bouchard, Louis-Olivier, Maximiliano A. Wilson, Robert Laforce, and Simon Duchesne. "White Matter Damage in the Semantic Variant of Primary Progressive Aphasia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, no. 04 (2019): 373–82. http://dx.doi.org/10.1017/cjn.2019.37.

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ABSTRACT:Background: The semantic variant of primary progressive aphasia (svPPA) is a form of dementia, mainly featuring language impairment, for which the extent of white matter (WM) damage is less described than its associated grey matter (GM) atrophy. Our study aimed to characterise the extent of this damage using a sensitive and unbiased approach. Methods: We conducted a between-group study comparing 10 patients with a clinical diagnosis of svPPA, recruited between 2011 and 2014 at a tertiary reference centre, with 9 cognitively healthy, age-matched controls. From diffusion tensor imaging
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Matias-Guiu, Jordi A., Vanesa Pytel, Laura Hernández-Lorenzo, et al. "Spanish Version of the Mini-Linguistic State Examination for the Diagnosis of Primary Progressive Aphasia." Journal of Alzheimer's Disease 83, no. 2 (2021): 771–78. http://dx.doi.org/10.3233/jad-210668.

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Background: Primary progressive aphasia (PPA) is a neurodegenerative syndrome with three main clinical variants: non-fluent, semantic, and logopenic. Clinical diagnosis and accurate classification are challenging and often time-consuming. The Mini-Linguistic State Examination (MLSE) has been recently developed as a short language test to specifically assess language in neurodegenerative disorders. Objective: Our aim was to adapt and validate the Spanish version of MLSE for PPA diagnosis. Methods: Cross-sectional study involving 70 patients with PPA and 42 healthy controls evaluated with the ML
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Brodeur, Catherine, Émilie Belley, Lisa-Marie Deschênes, et al. "Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy." Life 12, no. 5 (2022): 662. http://dx.doi.org/10.3390/life12050662.

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Background: Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by a progressive decline in visuospatial/visuoperceptual processing. PCA is accompanied by the impairment of other cognitive functions, including language abilities. Methods: The present study focused on three patients presenting with language complaints and a clinical profile that was compatible with PCA. In addition to neurological and neuroimaging examinations, they were assessed with comprehensive batteries of neuropsychological and neurolinguistic tests. Results: The general medical profile of th
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Mousavi, Seyyede Zohreh, Reyhaneh Jafari, Saman Maroufizadeh3, Mohammad Moez Shahramnia, Mahsa Pourmohammadi, and Nahid Jalilehvand. "Validity and Reliability of the Persian Version of Language Screening Test (LAST) for Patients in the Acute Phase of Stroke." Function and Disability Journal 3, no. 1 (2020): 91–100. http://dx.doi.org/10.32598/fdj.3.13.

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Background & Objectives: Aphasia is one of the most common consequences of a stroke; thus, screening tests for early diagnosis of the problem are necessary when dealing with aphasia patients. One of these screening tests is the Language Screening Test (LAST). The purpose of this study was to translate, validate, and utilize this test in the Persian language for patients after stroke. Methods: The original version of LAST was translated into Persian, and then administrated on 100 patients in the acute phase by two examiners at the patient’s bedside in order to check the inter-rater reliabil
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Guiraud, Vincent, Thierry Gallarda, David Calvet, et al. "Depression predictors within six months of ischemic stroke: The DEPRESS Study." International Journal of Stroke 11, no. 5 (2016): 519–25. http://dx.doi.org/10.1177/1747493016632257.

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Background Depression negatively affects rehabilitation and quality of life after stroke. Identifying in the acute phase patients at high risk for post-stroke depression would facilitate early detection of depressive symptoms. Methods The DEPRESS (Depression Predictors after Ischemic Stroke) study was a prospective cohort study designed to identify baseline predictors of depression occurring within six months after ischemic stroke and high-risk patients for post-stroke depression. All patients without aphasia were screened for depression by a neurologist using the Patient Health Questionnaire,
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Cerami, Chiara, Alessandra Dodich, Lucia Greco, et al. "The Role of Single-Subject Brain Metabolic Patterns in the Early Differential Diagnosis of Primary Progressive Aphasias and in Prediction of Progression to Dementia." Journal of Alzheimer's Disease 55, no. 1 (2016): 183–97. https://doi.org/10.3233/JAD-160682.

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<strong>Background and Objective:</strong> Primary progressive aphasia (PPA) is a clinical syndrome due to different neurodegenerative conditions in which an accurate early diagnosis needs to be supported by a reliable diagnostic tool at the individual level. In this study, we investigated in PPA the FDG-PET brain metabolic patterns at the single-subject level, in order to assess the case-to-case variability and its relationship with clinical-neuropsychological findings. <strong>Material and Methods:</strong> 55 patients (i.e., 11 semantic variant/sv-PPA, 19 non fluent variant/nfv-PPA, 17 logo
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Basilakos, Alexandra. "Contemporary Approaches to the Management of Post-stroke Apraxia of Speech." Seminars in Speech and Language 39, no. 01 (2018): 025–36. http://dx.doi.org/10.1055/s-0037-1608853.

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AbstractApraxia of speech (AOS) is a motor speech disorder that disrupts the planning and programming of speech motor movements. In the acute stage of stroke recovery, AOS following unilateral (typically) left hemisphere stroke can occur alongside dysarthria, an impairment in speech execution and control, and/or aphasia, a higher-level impairment in language function. At this time, perceptual evaluation (the systematic, although subjective, description of speech and voice characteristics) is perhaps the only “gold standard” for differential diagnosis when it comes to motor speech disorders. Th
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Carota, Antonio, Alain Nicola, Selma Aybek, et al. "ACUTE Vs LATE POST-STROKE MOOD DISORDERS." Stroke 32, suppl_1 (2001): 366. http://dx.doi.org/10.1161/str.32.suppl_1.366-a.

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P149 Background and Methods: We studied emotional behaviors and mood disorders in 165 consecutive patients with acute first-ever hemispheral stroke. In all patients, a specifically designed observational scale for behavioral appraisal (Emotional Behaviour Index Form or EBIF) was assessed daily for four days, starting within 48 hours. The EBIF, which is independent of language abilities, includes 38 rated items, divided in the categories of overt sadness, passivity, aggressiveness, indifference, disinhibition, denial and adaptation. Prospective evaluation, including a standardized neuropsycholo
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Mohamed, A., J. Wang, A. Gabr, W. Mustafa, M. O'Connor, and M. Mulroy. "232 DETECTION OF POST STROKE DEPRESSION IN ACUTE STROKE UNIT AT UNIVERSITY HOSPITAL." Age and Ageing 50, Supplement_3 (2021): ii9—ii41. http://dx.doi.org/10.1093/ageing/afab219.232.

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Abstract Background Depression is the most common neuropsychiatric manifestation after stroke. It is associated with lower satisfaction and quality of life in stroke survivors and their families. Routine screening for mood disturbance is recommended in stroke patients {Royal College of Physicians, 2016; National Office of Clinical Audit (NOCA) 2019}. The psychological impact of a stroke can present challenges for assessment and diagnosis. We audited the assessment and diagnosis of post stroke depression in a teaching hospital. Methods PHQ-9 was prospectively administered to stroke patients (an
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Jalali, Rakesh, Aleksandra Bieniecka, Marek Jankowski, et al. "The Absence of Typical Stroke Symptoms and Risk Factors Represents the Greatest Risk of an Incorrect Diagnosis in Stroke Patients." Journal of Personalized Medicine 14, no. 9 (2024): 964. http://dx.doi.org/10.3390/jpm14090964.

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Background: Stroke is one of the most misdiagnosed conditions that causes serious medical disabilities. Its early and accurate diagnosis by the emergency team is crucial for the patient’s survival. This study aimed to determine the percentage of brain strokes incorrectly diagnosed by paramedic teams and to analyze the factors influencing incorrect diagnoses. Methods: The data of 103 patients, mean age of 68.4 ± 14.96 years, admitted in 2019 to hospital emergency departments of the two hospitals in Olsztyn, Poland, were analyzed retrospectively. All patient data were obtained from their informa
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Fernández-Romero, Lucía, Florentina Morello-García, Robert Laforce, et al. "Comparative accuracy of Mini-Linguistic State Examination, Addenbrooke's Cognitive Examination, and Depistage Cognitif de Quebec for the diagnosis of primary progressive aphasia." Journal of Alzheimer’s Disease 102, no. 1 (2024): 67–76. http://dx.doi.org/10.1177/13872877241284199.

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Background Clinical diagnosis in primary progressive aphasia (PPA) is challenging. Recently, emphasis has been placed on the importance of screening evaluation. Three different screening tests that use different strategies based on the assessment of language (Mini-Linguistic State Examination, MLSE) or different cognitive domains (Addenbrooke's Cognitive Examination, ACE-III and Dépistage Cognitif de Québec, DCQ) have been proposed and independently validated. These tests aim to detect PPA and classify into the three main variants (non-fluent (nfvPPA), semantic (svPPA) and logopenic (lvPPA)).
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Poole, Matthew L., Amy Brodtmann, David Darby, and Adam P. Vogel. "Motor Speech Phenotypes of Frontotemporal Dementia, Primary Progressive Aphasia, and Progressive Apraxia of Speech." Journal of Speech, Language, and Hearing Research 60, no. 4 (2017): 897–911. http://dx.doi.org/10.1044/2016_jslhr-s-16-0140.

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Purpose Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressive aphasia (PPA), and progressive apraxia of speech in order to identify the most effective measures for diagnosis and monitoring, and to elucidate associations between speech and neuroimaging. Method Speech and neuroimaging data described in studies of FTD and PPA were systematically reviewed. A meta-analysis was conducted for speech measures that were used consistently in multiple studies. Results The methods and nomenclature used to describe speech in these disord
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Onyike, Chiadi U., Olga Pletnikova, Kelly L. Sloane, Campbell Sullivan, Juan C. Troncoso, and Peter V. Rabins. "Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration." Dementia & Neuropsychologia 7, no. 1 (2013): 83–87. http://dx.doi.org/10.1590/s1980-57642013dn70100013.

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ABSTRACT Objective: To describe characteristics of hippocampal sclerosis dementia. Methods: Convenience sample of Hippocampal sclerosis dementia (HSD) recruited from the Johns Hopkins University Brain Resource Center. Twenty-four cases with post-mortem pathological diagnosis of hippocampal sclerosis dementia were reviewed for clinical characterization. Results: The cases showed atrophy and neuronal loss localized to the hippocampus, amygdala and entorrhinal cortex. The majority (79.2%) had amnesia at illness onset, and many (54.2%) showed abnormal conduct and psychiatric disorder. Nearly 42% p
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Brown, Desmond A., Mark A. Whealy, Jamie J. Van Gompel, Lindsy N. Williams, and James P. Klaas. "Diagnostic Dilemma in Primary Blastomyces dermatitidis Meningitis: Role of Neurosurgical Biopsy." Case Reports in Neurology 7, no. 1 (2015): 63–70. http://dx.doi.org/10.1159/000381469.

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A 52-year-old male on chronic prednisone for polymyalgia rheumatica presented with a subacute history of headaches, nausea, phonophobia, intermittent diplopia and gait instability. He was hospitalized 2 weeks prior to presentation with extensive evaluations only notable for leptomeningeal inflammation on MRI. His symptoms progressively worsened and he developed aphasia. He was transferred to our facility where extensive spinal fluid examinations were repeated and were again nondiagnostic. Ultimately, a diagnostic skull-based biopsy was performed which demonstrated Blastomyces dermatitidis fung
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Martín-Dorta, Willian-Jesús, Alfonso-Miguel García-Hernández, Jonathan Delgado-Hernández, et al. "Psychometric Testing of the CEECCA Questionnaire to Assess Ability to Communicate among Individuals with Aphasia." International Journal of Environmental Research and Public Health 20, no. 5 (2023): 3935. http://dx.doi.org/10.3390/ijerph20053935.

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(1) Background: The CEECCA questionnaire assesses the ability to communicate among individuals with aphasia. It was designed using the NANDA-I and NOC standardised nursing languages (SNLs), reaching high content validity index and representativeness index values. The questionnaire was pilot-tested, demonstrating its feasibility for use by nurses in any healthcare setting. This study aims to identify the psychometric properties of this instrument. (2) Methods: 47 individuals with aphasia were recruited from primary and specialist care facilities. The instrument was tested for construct validity
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Weintraub, Sandra, Benjamin Rader, Christina Coventry, et al. "Familial language network vulnerability in primary progressive aphasia." Neurology 95, no. 7 (2020): e847-e855. http://dx.doi.org/10.1212/wnl.0000000000009842.

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ObjectiveTo investigate evidence of the potential role of early cortical vulnerability in the development of primary progressive aphasia (PPA).MethodA woman with a diagnosis of PPA and her 9 adult siblings, 7 with developmental language disabilities, underwent neuropsychological testing, structural MRI, and resting-state fMRI. Whole-exome sequencing was conducted for genes associated with dyslexia or with neurodegenerative dementia.ResultsThe siblings demonstrated lower verbal than nonverbal cognitive test scores in a developmental dyslexia pattern. On structural MRI, although the siblings did
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Buivolova, O. V., V. R. Stepanova, O. A. Soloukhina, et al. "Confirmation of the competitive validity of the Russian Aphasiological Test, a new standardized tool for the diagnosis of aphasia." S.S. Korsakov Journal of Neurology and Psychiatry 125, no. 3 (2025): 28. https://doi.org/10.17116/jnevro202512503228.

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Objective. To approve of the validity of a new diagnostic tool — the Russian Aphasiological Test (RAT) — by comparing the results of the RAT and the Scale for assessing the severity of speech disorders in patients with local brain lesions (Wasserman scale), commonly used in the Russian-speaking settings. Material and methods. One hundred stroke survivors were tested with RAT and the Wasserman Scale. A correlation analysis was conducted between the overall scores of these two tests and scores for individual tasks that check the integrity of comparable speech skills (comprehension, repetition, n
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Furlan, Fernanda Luiza Schumacher, Macleise Andres Lemes, Ligia Cecilia Fuverki Suguimatsu, Carolina Teixeira Furquim Pires, and Mara Lucia Schmitz Ferreira Santos. "X-LINKED ADRENOLEUKODYSTROPHY IN BRAZIL: A CASE SERIES." Revista Paulista de Pediatria 37, no. 4 (2019): 465–71. http://dx.doi.org/10.1590/1984-0462/;2019;37;4;00015.

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ABSTRACT Objective: To describe patients with different phenotypes of X-linked adrenoleukodystrophy: pre-symptomatic, cerebral demyelinating inflammatory adrenoleukodystrophy, adrenomyeloneuropathy and adrenal insufficiency only. Methods: Specific data related to epidemiology, phenotype, diagnosis and treatment of 24 patients with X-linked adrenoleukodystrophy were collected. A qualitative cross-sectional and descriptive-exploratory analysis was performed using medical records from a reference center in Neuropediatrics in Curitiba, Brazil, as well as an electronic questionnaire. Results: The m
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Bahia, Valéria Santoro, Mari-Nilva Maia da Silva, Rene Viana, et al. "Behavioral and activities of daily living inventories in the diagnosis of frontotemporal lobar degeneration and Alzheimer's disease." Dementia & Neuropsychologia 2, no. 2 (2008): 108–13. http://dx.doi.org/10.1590/s1980-57642009dn20200006.

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Abstract The differential diagnosis between frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD) is often challenging. Objectives: To verify the usefulness of behavioral and activities of daily living inventories in the differential diagnosis between FTLD and AD. Methods: Caregivers of 12 patients with FTLD (nine with frontotemporal dementia, two with semantic dementia and one with progressive non-fluent aphasia) and of 12 patients with probable AD were interviewed. The Brazilian version of the Frontal Behavioral Inventory (FBI) and Disability Assessment for Dementia (DAD ) we
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Kim, Hyun Soo, Deog Young Kim, Byoung Seok Ye, and Hyang Hee Kim. "Pause Characteristics by Utterance Position in Patients with Primary Progressive Aphasia Subtypes." Communication Sciences & Disorders 29, no. 4 (2024): 885–95. https://doi.org/10.12963/csd.240077.

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Objectives: Primary progressive aphasia (PPA) is a neurodegenerative disease characterized by prominent language impairments within the first two years of onset. PPA is clinically categorized into three subtypes: semantic variant (svPPA), logopenic variant (lvPPA), and non-fluent/agrammatic variant (nfvPPA). Pauses that occur during speech production in primary progressive aphasia (PPA) can serve as simple and reliable biomarkers for subtype classification and early diagnosis of PPA. This study aimed to investigate the characteristics of pauses in PPA subtypes during a picture description task
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Khidoyatova, D. N., R. M. Abdujamilova, L. M. Zuparova, and M. R. Mirkhalilova. "PROGNOSTIC VALUE OF VARIOUS PATHOGENETIC VARIANTS OF TRANSIENT ISCHEMIC ATTACKS." UZBEK MEDICAL JOURNAL 2, no. 3 (2021): 52–56. http://dx.doi.org/10.26739/2181-0664-2021-3-9.

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Transient ischemic attack(TIA), being a precursor of stroke, increases the risk of its development by up to 30% low awareness of the population about TIA symptoms, may cause late hospitalization of patients with its development and thereby cause stroke and reduce the effectiveness of treatment. Using a simple, practical ABCD 2 scale (age, arterial hypertension, presence of paresis and aphasia, duration of symptoms more than 60 minutes, diabetes mellitus) may be of predictive value in patients’ hospitalization. It is necessary to start the secondary prevention of stroke as soon as possible. The
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Förster, A., M. Al-Zghloul, H. Wenz, J. Böhme, C. Groden, and E. Neumaier-Probst. "Isolated punctuate hippocampal infarction and transient global amnesia are indistinguishable by means of MRI." International Journal of Stroke 12, no. 3 (2016): 292–96. http://dx.doi.org/10.1177/1747493016676613.

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Background Small punctuate lesions in the hippocampus on diffusion-weighted images are a typical finding in transient global amnesia. Consequently, it has been suggested that diffusion-weighted images findings might corroborate the diagnosis of transient global amnesia. However, isolated punctuate hippocampal infarction might be a differential diagnosis of transient global amnesia. Aim Evaluation of isolated punctuate hippocampal infarction frequency and comparison of its clinical presentation and MRI findings to transient global amnesia. Methods From an MRI database, we identified 10 patients
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Sheridan, Lisa, Cathy McHale, Joshi Dookhy, et al. "264 Incorporating Neurolinguistics and the Role of Speech and Language Therapy in a Specialist Memory Service." Age and Ageing 48, Supplement_3 (2019): iii17—iii65. http://dx.doi.org/10.1093/ageing/afz103.164.

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Abstract Background Speech and Language Therapy (SLT) is recognised as having a unique role in contributing to the overall neuropsychological assessment of people living with dementia and cognitive impairment. The role of the SLT within a memory clinic has become more widely understood. It is now recognised that speech and language characteristics are reported to be amongst the most reliable behavioural markers for distinguishing amongst different dementia subtypes, and specific analysis of a language production and delivery facilitates timely and more accurate diagnosis. Methods Patients with
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Wray, Faye, David Clarke, Madeline Cruice, and Anne Forster. "Development of a self-management intervention for stroke survivors with aphasia using co-production and behaviour change theory: An outline of methods and processes." PLOS ONE 16, no. 11 (2021): e0259103. http://dx.doi.org/10.1371/journal.pone.0259103.

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Background Self-management is a promising approach to improve quality of life after stroke. However, evidence for the appropriateness and effectiveness of self-management for stroke survivors with aphasia is limited. This article reports on the process used to develop a supported self-management intervention for stroke survivors with aphasia (SSWA) using co-production and behaviour change theory. Preparatory research included systematic reviews, and qualitative interviews and focus groups with SSWA, family members and speech and language therapists (SLTs). Materials and methods We conducted si
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Benzagmout, Mohammed, Peggy Gatignol, and Hugues Duffau. "RESECTION OF WORLD HEALTH ORGANIZATION GRADE II GLIOMAS INVOLVING BROCA'S AREA." Neurosurgery 61, no. 4 (2007): 741–53. http://dx.doi.org/10.1227/01.neu.0000298902.69473.77.

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Abstract OBJECTIVE Advances in functional mapping have enabled us to extend the indications of surgery for low-grade gliomas (LGGs) within eloquent regions. However, to our knowledge, no study has been specifically dedicated to the resection of LGGs within Broca's area. We report the first surgical series of LGGs involving this area by focusing on methodological and functional considerations. METHODS Seven patients harboring an LGG in Broca's area (revealed by partial seizures) had a language functional magnetic resonance imaging scan and then underwent operation while awake using intrasurgica
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