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Fabisiak, Luiza, and Karina Szczypor-Piasecka. "Diagnostic Analysis of Patients Qualified for Hip Replacement Using Multi-Criteria Methods." International Journal of Healthcare Information Systems and Informatics 15, no. 4 (2020): 56–69. http://dx.doi.org/10.4018/ijhisi.2020100104.
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Patients with advanced hip osteoarthritis are likely to suffer from biomechanical disorders. As many criteria inform how such patients are being qualified for alloplasty procedures, this article proposes a multi-criteria decisional framework in qualifying patients for treatment while undergoing diagnostic analysis for hip replacement surgery. In order to assess the patient's health condition, the competence of physicians and physiotherapists must first be checked. After creating the expert preference model and decision tree, the AHP method was applied followed by the Electre Tri method in the next stage of verification. Integrating these analytic procedures, a group of patients can be quickly evaluated and meaningfully profiled. Specifically, these patients can be classified in respect of their condition determined during hospitalisation as per the severity of degenerative disease and on the basis of their subjective feelings and diagnostics. The proposed methodology promises to allow optimal treatment to be assigned while enabling the appropriate classification and verification within group of patients targeted for hip replacement surgery.
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Krška, Zdeněk, Jan Šváb, David Hoskovec, and Jan Ulrych. "Pancreatic Cancer Diagnostics and Treatment – Current State." Prague Medical Report 116, no. 4 (2015): 253–67. http://dx.doi.org/10.14712/23362936.2015.65.
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Pancreatic ductal adenocarcinoma (PDAC) represents permanent and ever rising issue worldwide. Five-year survival does not exceed 3 to 6%, i.e. the worst result among solid tumours. The article evaluates the current state of PDAC diagnostics and treatment specifying also development and trends. Percentage of non-resectable tumours due to locally advanced or metastatic condition varies 60–80%, mostly over 80%. Survival with non-resectable PDAC is 4 to 8 months (median 3.5). In contrast R0 resection shows the survival 18–27 months. Laboratory and imaging screening methods are not indicated on large scale. Risk factors are smoking, alcohol abuse, chronic pancreatitis, diabetes mellitus. Genetic background in most PDAC has not been detected yet. Some genes connected with high risk of PDAC (e.g. BRCA2, PALB2) have been identified as significant and highly penetrative, but link between PDAC and these genes can be seen only in 10–20%. This article surveys perspective oncogenes, tumour suppressor genes, microRNA. Albeit CT is still favoured over other imaging methods, involvement of NMR rises. Surgery prefers the “vessel first” approach, which proves to be justified especially in R0 resection. According to EBM immunotherapy same as radiotherapy are not significant in PDAC treatment. Chemotherapy shows limited importance in conversion treatment of locally advanced or borderline tumours or in case of metastatic spread. Unified procedures cannot be defined due to inhomogenous arrays. Surgical resection is the only chance for curative treatment of PDAC and depends mainly on timely indication for surgery and quality of multidisciplinary team in a high-volume centre.
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Veselyy, M. U., and S. V. Veselyy. "Diagnostics, treatment and rehabilitation of testicular torsion in children (literature review)." Paediatric Surgery. Ukraine, no. 2(71) (June 25, 2021): 63–71. http://dx.doi.org/10.15574/ps.2021.71.63.
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Testiculat torsion (TT) is an emergency condition that is accompanied by partial or complete chorda spermatica vessels compression resulting in testicular infraction. TT main symptoms are sharp pain, scrotal hyperemia, generalized edema, nausea, vomiting and unconsciousness. However, these symptoms are characteristic of many other acute diseases of genital gland. In course of time the symptoms are less defined, which in its turn raises the issue of timely differential diagnostics. Purpose – to optimize and generalize about modern literature data on testicular torsion in children diagnostics, treatment and rehabilitation. Medical history taking, considering clinical data and checking the symptoms typical for PP during diagnostic process is crucial. It is important to use instrumental diagnostic methods, with echographic and scyntigraphic ones to be the main ones. After having confirmed PP diagnosis, treatment has to be started immediately. There are two methods of testicular detorsion, i.e. manual bloodless detorsion and invasive detorsion with further orchiopexy. Post-surgical phase is significant for preserving the patient’s fertility in the future. Post-TT rehabilitation includes medication, physiotherapeutic procedures, genital gland fixing from contralateral side, and, in case of testicle loss through non-timely treatment, testicle endoprosthesing. Testicular torsion is a complicated and understudied issue. Critical ischemia sets on in 12–16 hours from the onset of disease. As of today, the issue of diagnostics, treatment and rehabilitation of patients with acute testicular torsion has not been studied completely and requires further study. No conflict of interest was declared by the authors. Key words: testicular torsion, differential diagnosis, orchiopexy, endoprosthesis.
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Koudijs, Marco J., Lennart A. Kester, Jayne Y. Hehir-Kwa, et al. "RNA-Sequencing Improves Diagnostics and Treatment of Pediatric Hematological Malignancies." Blood 138, Supplement 1 (2021): 107. http://dx.doi.org/10.1182/blood-2021-147692.
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Abstract Background Diagnosis and treatment of hematological malignancies relies increasingly on the detection of underlying genetic abnormalities. Various laboratory techniques, including karyotyping, SNP-array, FISH, MLPA and RT-PCR are typically required to detect the full spectrum of clinically relevant genetic aberrations. These techniques are also hampered in their sensitivity by their targeted approach or lack of resolution. Ideally, an unbiased genome wide approach like RNA sequencing (RNA-seq) as a one-test-fits-all, could save costs and efforts and streamline diagnostic procedures. In the Netherlands, the care for all children with oncological disorders has been concentrated in a single, national center. Within the Laboratory of Childhood Cancer Pathology, we aim for a comprehensive diagnostic pipeline by implementing RNA-seq to aid diagnosis, prognosis and treatment of all children with cancer in the Netherlands. Methods We have established an RNA-seq based diagnostic pipeline, primarily aimed at detecting gene fusion events. Library prep is performed on 50-300 ng total RNA isolated from fresh (frozen) samples, followed by ribo-depletion and subsequent paired-end sequencing (2x150 nt) using the Illumina NovaSeq platform. Data is analyzed using the StarFusion algorithm for gene-fusion detection. We are prospectively comparing the results with routine diagnostic procedures. In addition, we are validating the detection of single nucleotide variants (SNVs) from RNA-seq data and developing a diagnostic classifier, using a nearest neighbor network approach. Results Based on RNA-seq profiling in diagnostics for all patients entering the Princess Maxima Center, there are several use-cases that highlight the value of RNA-seq. 1) In a prospective cohort of 244 patients (pan-cancer, including 97 hematological malignancies) we have shown that the diagnostic yield for detecting gene fusion events increased by approximately 40% compared to classical methods. An example is the TNIP1--PDGFRB gene fusion in a patient with pre B-ALL, making this patient eligible for imatinib treatment, which was not detected by other methods. 2) Variant calling on RNA-seq shows that activating mutations in e.g. KRAS are detected with high sensitivity, stratifying patients for therapeutic MEK intervention. 3) By expression outlier analysis, we were able to detect various promotor exchanges, e.g. IGH-MYC or IGH--DUX4, which are typically hard to detect by molecular techniques since the genomic breakpoint is highly variable and no chimeric transcript is formed. 4) Preliminary results from our diagnostic classifier show its potential to predict subclasses of hematological malignancies, e.g. high-hyperdiploid or bi-phenotypic ALL patients. 5) Fusion gene breakpoints detected by RNA-seq serve as a target for MRD analysis, allowing us to monitor disease progression and therapy response in individual patients. Currently, RNA-seq data is available for more than 1500 pediatric tumor samples. At the upcoming conference we will present an update of our results and some typical cases highlighting the added value of RNA-seq in routine diagnostics. Conclusion We show that RNA-seq on pediatric cancer samples is feasible and of great value for routine diagnostics. It has a higher sensitivity to detect gene fusion events compared to targeted assays. RNA-seq based gene fusion detection, in combination with mutation and expression analysis, is also promising to improve classification of malignancies, prognosis and stratification of patients for targeted therapies. Disclosures No relevant conflicts of interest to declare.
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Schäfers, M. "Methods and clinical applications in nuclear cardiology: a position statement." Nuklearmedizin 41, no. 01 (2002): 3–13. http://dx.doi.org/10.1055/s-0038-1623996.
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SummaryNuclear cardiological procedures have paved the way for non-invasive diagnostics of various partial functions of the heart. Many of these functions cannot be visualised for diagnosis by any other method (e. g. innervation). These techniques supplement morphological diagnosis with regard to treatment planning and monitoring. Furthermore, they possess considerable prognostic relevance, an increasingly important issue in clinical medicine today, not least in view of the cost-benefit ratio.Our current understanding shows that effective, targeted nuclear cardiology diagnosis – in particular for high-risk patients – can contribute toward cost savings while improving the quality of diagnostic and therapeutic measures.In the future, nuclear cardiology will have to withstand mounting competition from other imaging techniques (magnetic resonance imaging, electron beam tomography, multislice computed tomography). The continuing development of these methods increasingly enables measurement of functional aspects of the heart. Nuclear radiology methods will probably develop in the direction of molecular imaging.
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Bitenc-Jasiejko, Aleksandra, Krzysztof Konior, and Danuta Lietz-Kijak. "Meta-Analysis of Integrated Therapeutic Methods in Noninvasive Lower Back Pain Therapy (LBP): The Role of Interdisciplinary Functional Diagnostics." Pain Research and Management 2020 (March 20, 2020): 1–17. http://dx.doi.org/10.1155/2020/3967414.
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Introduction. Lower back pain (LBP) is almost a problem of civilizations. Quite often, it is a consequence of many years of disturbed distribution of tension within the human body caused by local conditions (injuries, hernias, stenoses, spondylolisthesis, cancer, etc.), global factors (postural defects, structural integration disorders, lifestyle, type of activity, etc.), or systemic diseases (connective tissue, inflammation, tumours, abdominal aneurysm, and kidney diseases, including urolithiasis, endometriosis, and prostatitis). Therefore, LBP rehabilitation requires the use of integrated therapeutic methods, combining the competences of interdisciplinary teams, both in the process of diagnosis and treatment. Aim of the Study. Given the above, the authors of the article conducted meta-analysis of the literature in terms of integrated therapeutic methods, indicating the techniques focused on a holistic approach to the patient. The aim of the article is to provide the reader with comprehensive knowledge about treating LBP using noninterventional methods. Material and Methods. An extensive search for the materials was conducted online using PubMed, the Cochrane database, and Embase. The most common noninterventional methods have been described, as well as the most relevantly updated and previously referenced treatment of LBP. The authors also proposed noninvasive (measurable) diagnostic procedures for the functional assessment of the musculoskeletal system, including initial, systematic, and cross-sectional control. All figures and images have been prepared by the authors and are their property. Results. This review article goes beyond combining a detailed description of each procedure with full references, as well as a comprehensive discussion of this very complex and troublesome problem. Conclusions. Lower back pain is a serious health problem, and this review article will help educate physicians and physiotherapists dealing with LBP in the options of evidence-based treatment. Ultimately, the article introduces and postulates the need to systematize therapeutic procedures in LBP therapy, with a long-term perspective.
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Hadzi-Djokic, Jovan, Uros Babic, Aleksandar Argirovic, et al. "Etiopathogenesis, diagnostics and history of surgical treatment of stress urinary incontinence." Acta chirurgica Iugoslavica 61, no. 1 (2014): 85–90. http://dx.doi.org/10.2298/aci1401085h.
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Urinary incontinence represents involuntary urine leakage into the urethra. This pathological condition represents a major medical, social and hygienic problem. The paper presents risk factors for development of the disorder, as well as diagnostic methods applied in evaluation of the female patients. Chronological review of diverse surgical techniques used in treatment of stress urinary incontinence reported in the published scientific papers is also presented. Review of the literature data was also per- formed. Sling procedures with application of suburethral loops have been used since the beginning of the last century in treatment of this disorder. Surgical treatment of stress urinary incontinence is applied when conservative treatment fails to give any effects according to strictly defined indications. During the last 100 years, surgical techniques have undergone different improvements and the results have also been significantly improved.
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Trzos, Arkadiusz, Wiktoria Kudła, and Karol Łyziński. "TRIAGE AND EMERGENCY MEDICAL MANAGEMENT OF THE ACUTE RADIATION SYNDROME." Emergency Medical Service 7, no. 3 (2020): 215–23. http://dx.doi.org/10.36740/emems202003110.
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Introduction: Medical personnel of the state Emergency Medical Services (EMS) will be the first element involved in providing assistance to victims of radiation incidents. Triage, initial diagnosis and further patient medical management will depend on their actions. In many radiation incidents, initial radiation triage and early diagnostics will be carried out in the emergency department (ED) or trauma center (TC). Extended triage, diagnosis of ARS and proper treatment will be continued in specialist centers. The aim: To present a model of patient medical management including initial triage and early diagnosis of ARS that can be carried out at the ED and TC. Material and methods: The initial medical procedures prepared by expert groups were presented. The choice of procedures was made in terms of the possibility of their application by the EMS teams in Poland. Particular attention was paid to the method of initial triage, based on the clinical condition and laboratory diagnostics. Results: Based on the material collected, the path of the initial medical procedure was presented. Variants of the radiation triage, interpretation of clinical parameters and results of laboratory tests are presented. The methods of initial treatment and the method of qualification for specialist treatment, and new methods of treating patients were also described. Conclusions: An adequate evaluation of radiation incidents, determining the absorbed dose of ionising radiation and ARS, as well as initial triage seem to be crucial skills of the EMS workers.
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Müller, Sabrina, Alina Brandes, Julia Knierim, et al. "Epidemiology, Diagnostics, and Treatment of Narcolepsy in Germany: The DORMIO Study." Journal of Sleep Medicine 18, no. 2 (2021): 88–99. http://dx.doi.org/10.13078/jsm.210007.
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Objectives: This study aimed to investigate the prevalence, incidence, and real-world diagnostic and treatment patterns, healthcare resource utilization (HCRU), and associated costs of narcolepsy in Germany. Methods: This study was based on German claims data (2013–2018). Any patient with at least two outpatient specialist diagnoses and/or one inpatient diagnosis of narcolepsy was eligible for inclusion. Three cohorts were specified: 1) narcolepsy-prevalent patients alive on July 1, 2017; 2) narcolepsy-incident patients; and 3) newly treated patients. Descriptive analyses of the outcome measures were conducted. Results: We identified 133 prevalent narcolepsy patients (mean age: 46.2 years, 36.3% female), 71 incident patients, and 41 treatment starters. The prevalence of narcolepsy was 3.1–9.1 per 100,000 persons within the German population; the cumulative incidence between July 1, 2017, and June 30, 2018, was 0.83/100,000 persons. Among the incident patients, 62.0% underwent at least one predefined diagnostic procedure. Modafinil was the most prescribed medication for the treatment starters (46.3%) and prevalent patients (24.1%), but 59.4% of the prevalent patients did not receive any narcolepsy-specific pharmacological treatment. Prevalent patients with narcolepsy consulted physicians significantly more often than a healthy matched control group and experienced more all-cause hospitalizations. The mean total direct healthcare costs were higher for narcolepsy patients by €2,429 per patient-year. Conclusions: Not all narcolepsy patients undergo appropriate diagnostic procedures or narcolepsy-specific medications, as indicated by the treatment guidelines. More emphasis on the optimization of the management of this disease is needed, given its high prevalence and associated economic burden.
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Stofkova, Z., E. Novakova, and V. Sadloňová. "New Approaches to Diagnostics of C.Difficile Infection." Acta Medica Martiniana 20, no. 1 (2020): 18–26. http://dx.doi.org/10.2478/acm-2020-0003.
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AbstractIntroduction:Clostridium difficile infection (CDI) is the most common infectious cause of diarrhoea in hospitalised patients. It is a severe issue with increasing incidence in healtcare facilities and commmunities. Early and appropriate testing of CDI is very imortant. There are many different approaches that can be used in the CDI laboratory diagnostics. Recently performed studies evaluated diagnostic algorithms to optimize laboratory CDI diagnostics. The aim of the work was to implement an optimal algorithm of testing methods in CDI diagnostics.Materials and methods: The retrospective analysis of patients’ samples suspected on CDI was carried out in 2017. The data was analysed from the Laboratory Klinicka Biochemia in Zilina. The application of ESCMID re -commendation criteria for algorithm of testing, together with procedures in laboratory practice was carried out.Results: The analysis of the data showed that the applied algorithm or testing in CDI and highlighted the importance of preanalytic phase, and the evaluation of testing methods and results, together with clinical findings. Two- and three- step algorithm together with cultivation methods were applied. 87,6% of samples could be eva -luated with positive or negative results according to the 2-step algorhitm. Further samples were assessed and tested by ELISA test or PCR method.Conclusion: CDI represents a significant burden in healthcare facilities. An early diagnostics and interpretation helps to start the early treatment and helps in surveillence of the infection.
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Poley, Jan-Werner, and Sara Campos. "Methods and outcome of the endoscopic treatment of ampullary tumors." Therapeutic Advances in Gastrointestinal Endoscopy 13 (January 2020): 263177451989978. http://dx.doi.org/10.1177/2631774519899786.
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Ampullary tumors are rare neoplasms but increasingly encountered due to an increase in diagnostic procedures, mainly upper gastrointestinal endoscopy. Diagnosis, staging, and treatment of these tumors are described and recommendations given based on the most recent literature.
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Pavelets, K. V., A. K. Ushkats, and D. V. Gacko. "FIBROCHOLODOSCOPY IN DIAGNOSTICS AND TREATMENT OF COMPLEX FORMS OF CHOLEDOCHOLITHIASIS." Bulletin of the Russian Military Medical Academy 21, no. 1 (2019): 43–46. http://dx.doi.org/10.17816/brmma13040.
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Relevance of the topic: endoscopic intraoperative choledochoscopy with traditional surgical procedures is a highly informative research in the diagnosis and treatment of choledocholithiasis. Objective: to evaluate the effectiveness of intraoperative use of fibrocholedochoscopy in the diagnosis and treatment of "complex" forms of choledocholithiasis. Materials and methods: Between 2011 and 2017, 88 patients underwent treatment for "complicated" forms of choledocholithiasis using intraoperative fibrocholedochoscopy. Results: after dissection of the choledochal wall and extraction of large concrements from the lumen, a fibrocholedochoscopy was performed. The fibrocholedochoscope was inserted into the lumen of the common bile duct through a formed opening with examination of the biliary tract. An obligatory condition for assessing the permeability of the distal sections of the bile ducts was the carrying out of an endoscope through the OBD zone. The remaining remaining calculi were recovered with the help of Dormia baskets (15 (17%) cases). In 86 (97.7%) patients, the operation is completed by the imposition of a hollow stitch of choledoch (priority reference No. 2018122530, 2018). Conclusion: fibrocholedochoscopy in the treatment of complex forms of choledocholithiasis allows to methodically evaluate the biliary tract, perform lithoextraction from the proximal and distal sections.
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Филатова, O. Filatova, Хадарцева, K. Khadartseva, Еськов, and Valeriy Eskov. "Two types of approaches at personification medicine development." Complexity. Mind. Postnonclassic 4, no. 1 (2015): 81–88. http://dx.doi.org/10.12737/10869.
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It is evident that requirement of medical personification includes two procedures: individual (with uninterrupted procedure of human organism state measurement) diagnostics and the second part which is connected with uninterrupted control of the efficiency of medical treatment and measurements of human organism parameters. According to classic deterministic-stochastic approaches we don´t have any possibility for realization of the basic principle in medicine because every human organism has its own specific features. We conduct the diagnostics according to beha-vior of state vector of human organism in phase space of states according to every coordinates of human´s state vector and with calculation of quasiattractors. It was presented new bioinformational methods and software for calculation of quasiattractors parameters for dissolving such contradic-tions between deterministic-stochastic medicine and the use of theory of chaos self-organization where the state vector of human organism demonstrates uninterrupted movements. The practical results of such procedure are also presented according to the theory of chaos self-organization.
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Fratrić, Ivana, Dragan Šarac, Jelena Antić, Marina Đermanov, and Radoica Jokić. "Impalpable Testis: Evaluation of Diagnostic and Treatment Procedures and Our Treatment Protocol." BioMed Research International 2018 (July 17, 2018): 1–5. http://dx.doi.org/10.1155/2018/3143412.
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Introduction. The aim of this study is to present our treatment protocol for impalpable testis. Material and Methods. In a retrospective study we analyzed clinical data including diagnostic procedures, intraoperative findings, final diagnosis, treatment modality, and outcome of patients with impalpable testis who underwent surgery from January 2010 until December 2015. Results. Ninety-one patients were admitted under the diagnosis of impalpable testis. In 39 patients ultrasound detected testis in the inguinal canal and orchidopexy was done. In 25 patients (48.08%) laparoscopy showed the entrance of the spermatic cord into the inguinal canal. Open exploration of the inguinal canal was done, testicular remnant removed, and appropriate testicular prosthesis implanted. Twenty patients (20/52) underwent orchidopexy of the abdominal testis (46.51%), 4 of which underwent Fowler-Stevens procedure in two stages, and in 16 patients deliberation of the testis and spermatic cord was sufficient to place the testis into the scrotum. Conclusions. Excision of the testicular nubbin is highly recommendable, as well as implantation of the testicular prosthesis at the time of orchiectomy.
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Jovanovic, Milan, Mirjana Milovanovic, Vojislav Ilic, and Vanja Krstic. "Basic therapeutic procedures in oncology of dogs and cats." Veterinarski glasnik 66, no. 5-6 (2012): 439–47. http://dx.doi.org/10.2298/vetgl1206439j.
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Speedy and reliable diagnostics of a malignant disease is of great importance as it enables the veterinarian to begin administering therapy and to provide the corresponding prognosis. Once the diagnosis is made, the necessary therapeutic procedure is administered. Depending on the form and type of malignant process, the following therapeutic measures can be applied: surgical therapy, radiotherapy (radiation therapy), chemotherapy, immuno therapy, molecular-gene targetted therapy, electrochemotherapy and electrogenic therapy, cryo therapy - cryo surgery, hyperthermia, photodynamic therapy, and supportive therapy. It is quite frequent that two or more therapeutic methods are used in the treatment of malignant diseases in dogs and cats. Each of these methods has its advantages and faults in connection with costs, availability, sensitivity, specificity, and quality. Every one of them has its area of implementation and yields different information depending on the nature and position of the primary lesion, the presence of metastases, as well as possible complications that are frequent in oncology patients.
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Tyurikova, O., Y. Dembitskaya, K. Yashin, et al. "Perspectives in Intraoperative Diagnostics of Human Gliomas." Computational and Mathematical Methods in Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/479014.
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Amongst large a variety of oncological diseases, malignant gliomas represent one of the most severe types of tumors. They are also the most common type of the brain tumors and account for over half of the astrocytic tumors. According to different sources, the average life expectancy of patients with various glioblastomas varies between 10 and 12 months and that of patients with anaplastic astrocytic tumors between 20 and 24 months. Therefore, studies of the physiology of transformed glial cells are critical for the development of treatment methods. Modern medical approaches offer complex procedures, including the microsurgical tumor removal, radiotherapy, and chemotherapy, supplemented with photodynamic therapy and immunotherapy. The most radical of them is surgical resection, which allows removing the largest part of the tumor, reduces the intracranial hypertension, and minimizes the degree of neurological deficit. However, complete removal of the tumor remains impossible. The main limitations are insufficient visualization of glioma boundaries, due to its infiltrative growth, and the necessity to preserve healthy tissue. This review is devoted to the description of advantages and disadvantages of modern intraoperative diagnostics of human gliomas and highlights potential perspectives for development of their treatment.
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Kruse, Abdel-Azim, Kim, et al. "Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia." International Journal of Molecular Sciences 21, no. 3 (2020): 1054. http://dx.doi.org/10.3390/ijms21031054.
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Minimal residual disease (MRD) refers to a chemotherapy/radiotherapy-surviving leukemia cell population that gives rise to relapse of the disease. The detection of MRD is critical for predicting the outcome and for selecting the intensity of further treatment strategies. The development of various new diagnostic platforms, including next-generation sequencing (NGS), has introduced significant advances in the sensitivity of MRD diagnostics. Here, we review current methods to diagnose MRD through phenotypic marker patterns or differential gene patterns through analysis by flow cytometry (FCM), polymerase chain reaction (PCR), real-time quantitative polymerase chain reaction (RQ-PCR), reverse transcription polymerase chain reaction (RT-PCR) or NGS. Future advances in clinical procedures will be molded by practical feasibility and patient needs regarding greater diagnostic sensitivity.
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Jagannathan, Jay, Aaron S. Dumont, John A. Jane, and Edward R. Laws. "Pediatric sellar tumors: diagnostic procedures and management." Neurosurgical Focus 18, no. 6 (2005): 1–5. http://dx.doi.org/10.3171/foc.2005.18.6.7.
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The diagnosis and management of pediatric sellar lesions is discussed in this paper. Craniopharyngiomas account for the majority of pediatric sellar masses, and pituitary adenomas are extremely uncommon during childhood. The diagnosis of sellar lesions involves a multidisciplinary effort, and detailed endocrinological, ophthalmological, and neurological testing is critical in the evaluation of a new sellar mass. The management of pituitary adenomas varies depending on the entity. For most tumors other than prolactinomas, transsphenoidal resection remains the mainstay of treatment. Less invasive methods, such as endoscopic transsphenoidal surgery and stereotactic radiosurgery, have shown promise as primary and adjuvant treatment modalities, respectively.
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Jokic, Radoica, and Pavle Milosevic. "Acute pancreatitis in children." Medical review 65, no. 1-2 (2012): 69–71. http://dx.doi.org/10.2298/mpns1202069j.
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Introduction. Acute pancreatitis in children is mostly due to abdominal trauma, diseases or congenital anomalies of the biliary-pancreatic tree. Both exogenous and endogenous functions of the gland could be disturbed by various levels of damage. Clinical Finding and Diagnostics. Acute abdominal pain, gastrointestinal signs and general deterioration are the main clinical findings. The examination can be completed by blood and urine tests of amylase, electrolytes level, and the C-reactive protein. In addition to these tests, ultrasound, computed tomography and endoscopy are required as well. Therapeutic Methods. The therapy of choice is non-operative treatment using medicaments to control the pain, decrease the pancreatic activity and prevent further complications. If the conservative treatment fails, the surgical approach is necessary: drainage, resections, by-pass procedures, etc. Conclusion. Acute pancreatitis is a very serious disease in childhood. Clinical experience and rational approach are very important in the diagnostic and therapeutic methods.
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Vicko, Ferenc, Zoran Radovanovic, Tatjana Ivkovic-Kapicl, et al. "Intraoperative digital specimen radiography in the treatment of nonpalpable breast lesions." Srpski arhiv za celokupno lekarstvo 145, no. 7-8 (2017): 378–81. http://dx.doi.org/10.2298/sarh161215071v.
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Introduction/Objective. About a third of the breast lesions on mammography are clinically occult. The goals of surgical treatment are to locate, remove, and verify their presence in the removed breast tissue. Standard specimen mammography (SSM) has been an official procedure for the latter, while intraoperative digital specimen radiography (IDSR) was introduced recently. The aim of this study was to evaluate the use of IDSR versus SSM and possible benefits regarding the duration of the procedures (operating room occupancy), availability of digital mammography for additional number of patients, surgeon productivity, and the quality of performed services. Methods. A retrospective chart review of 109 patients who underwent IDSR for nonpalpable breast lesions was performed between January 2014 and June 2016. We compared the difference in the duration of IDSR versus SSM procedure. We also observed the number of re-excisions and evaluated time-saving in the operating room workflow. Results. The average duration of surgery in the IDSR group of patients was 51 minutes, compared to 64 minutes in the SSM group. Every IDSR procedure saved 13 minutes over the standard SSM. That would allow another 28 procedures in the same time frame, with the same quality of service compared with SSM. In that way we increased productivity by 27.5%. Additional operation/surgery was needed for histologically involved surgical margins in three cases (2.75%). Conclusion. The use of new technology resulted in the rationalization of the operative room workflow and gave better productivity. More savings were obtained through the increase of digital mammography capacity for diagnostics, decrease of anesthesia duration, and better management of human resources. The number of ?true? re-excisions, involving additional surgery, remained similar after introducing IDSR.
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Lin, Peter H., Keun-Ho Yang, Kenneth R. Kollmeyer, et al. "Treatment outcomes and lessons learned from 5134 cases of outpatient office-based endovascular procedures in a vascular surgical practice." Vascular 25, no. 2 (2016): 115–22. http://dx.doi.org/10.1177/1708538116657506.
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Introduction The office-based endovascular facility has increased in number recently due in part to expedient patient experience. This study analyzed treatment outcomes of procedures performed in our office-based endovascular suite. Methods Treatment outcomes of 5134 consecutive procedures performed in our office-based endovascular suites from 2006 to 2013 were analyzed. Five sequential groups (group I–V) of 1000 consecutive interventions were compared with regard to technical success and treatment outcomes. Results Our patients included 2856 (56%) females and 2267 (44%) males. Procedures performed included diagnostic arteriogram, arterial interventions, venous interventions, dialysis access interventions, and venous catheter management, which were 1024 (19.9%), 1568 (30.6%), and 3073 (60.0%), 621(12.1%), and 354 (6.9%), respectively. The complication rates for group I, II, III, IV, and V were 3%, 1.5%, 1%, 1.1%, and 0.7%, respectively. The complication rate was higher in group I when compared to each of the remaining four groups ( p < 0.05). Nine patients (0.18%) died within the 30-day period following their procedures, and none were procedure related. Conclusions Endovascular procedure can be performed safely in an office-based facility with excellent outcomes. Lessons learned in establishing office-based endovascular suites with efforts to reduce procedural complications and optimize quality patient care are discussed.
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Bogomolov, A. I., I. L. Davydkin, E. A. Savinov, N. S. Popel'nyuk, and K. V. Naumova. "Assessing risks of developing myeloproliferative diseases complications with laser doppler flowmetry." Health Risk Analysis, no. 3 (September 2020): 160–68. http://dx.doi.org/10.21668/health.risk/2020.3.19.
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Public healthcare in Russia faces many challenges; meeting them requires non-standard and innovative approaches. The set tasks are being solved within the «Public healthcare development» State program. A sub-program within it is called «Development and implementation of innovative diagnostics, prevention, and treatment procedures as well as basics of personified medicine». This sub-program involves wide use of information and digital technologies. Personified medicine envisages developing such methods that would allow early detection of a probable disease even at a preliminary stage in examining a patient; this detection is to be based on a simple and relatively cheap diagnostic technology and to provide a medical center with reliable data on detected signs of a disease for a further diagnosis. Mass use of such technologies also requires truly reliable mathematic procedures and models for putting a preliminary diagnosis. At present cardiovascular diseases are still the leading cause of death all over the world; they develop due to variable factors including influence exerted by malignant neoplasms and also due to chemotherapy. The paper contains data collected by contemporary medical experts on case histories and complications of myeloproliferative diseases caused by vascular system pathology that holds the first rank place as per mortality worldwide. It was detected that both pathological cellular mass and medications applied to treat myeloproliferative neoplasms could produce adverse effects on vascular endothelium damage to which plays the leading role in cardiovascular continuum. To assess risks of myeloproliferative diseases complications, we examined patients using Laser Doppler Flowmetry (LDF). The results were processed with a logistic regression model. As per ROC-analysis results the obtained diagnostic criterion has sensitivity (1 – β) and specificity, (1 – α) that are equal to 0.87 and 0.96 accordingly, and it means diagnostics is high-quality. The procedure and the mode can be applied in digital medicine.
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Bogomolov, A. I., I. L. Davydkin, E. A. Savinov, N. S. Popel'nyuk, and K. V. Naumova. "Assessing risks of developing myeloproliferative diseases complications with laser doppler flowmetry." Health Risk Analysis, no. 3 (September 2020): 160–68. http://dx.doi.org/10.21668/health.risk/2020.3.19.eng.
Full textAbstract:
Public healthcare in Russia faces many challenges; meeting them requires non-standard and innovative approaches. The set tasks are being solved within the «Public healthcare development» State program. A sub-program within it is called «Development and implementation of innovative diagnostics, prevention, and treatment procedures as well as basics of personified medicine». This sub-program involves wide use of information and digital technologies. Personified medicine envisages developing such methods that would allow early detection of a probable disease even at a preliminary stage in examining a patient; this detection is to be based on a simple and relatively cheap diagnostic technology and to provide a medical center with reliable data on detected signs of a disease for a further diagnosis. Mass use of such technologies also requires truly reliable mathematic procedures and models for putting a preliminary diagnosis. At present cardiovascular diseases are still the leading cause of death all over the world; they develop due to variable factors including influence exerted by malignant neoplasms and also due to chemotherapy. The paper contains data collected by contemporary medical experts on case histories and complications of myeloproliferative diseases caused by vascular system pathology that holds the first rank place as per mortality worldwide. It was detected that both pathological cellular mass and medications applied to treat myeloproliferative neoplasms could produce adverse effects on vascular endothelium damage to which plays the leading role in cardiovascular continuum. To assess risks of myeloproliferative diseases complications, we examined patients using Laser Doppler Flowmetry (LDF). The results were processed with a logistic regression model. As per ROC-analysis results the obtained diagnostic criterion has sensitivity (1 – β) and specificity, (1 – α) that are equal to 0.87 and 0.96 accordingly, and it means diagnostics is high-quality. The procedure and the mode can be applied in digital medicine.
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Kotel’Nikova, L. P., S. A. Plaksin, P. L. Kudryavtsev, and L. I. Farshatova. "Pulmonary-pleural complications of pancreatitis." Grekov's Bulletin of Surgery 176, no. 3 (2017): 28–31. http://dx.doi.org/10.24884/0042-4625-2017-176-3-28-31.
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OBJECTIVE. The authors investigated pulmonary-pleural complications of pancreatitis and evaluated results of CT examination in diagnostics and possibility of low invasive surgery in treatment of pancreaticogenic pleurisy. MATERIAL AND METHODS. A retrospective analysis was made of 156 medical histories of patients with acute pancreatitis and their results. An ultrasound examinations of the chest and CT scan were applied in order to determine lung tissue condition and presence of fluid in pleural cavities. RESULTS. The application of CT in diagnostics of pulmonary-pleural complications allowed doctors to identify an effusion in pleural cavities in 3,5-50 % patients with acute pancreatitis. The number and localization of effusions were defined more precisely. CONCLUSIONS. Mini-invasive procedures (puncture, videothoracoscopy) with examination of exudate on amylase activity and biopsy of pleura determined the causes of pleuritis. This was effective in pleritis elimination against a background of different methods of treatment of pancreatitis.
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Ćwikiel, W. "Interventional procedures involving portal vein circulation: a review." Acta Radiologica 47, no. 2 (2006): 145–56. http://dx.doi.org/10.1080/02841850500466567.
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Rapid development of diagnostic radiological methods during recent decades has been followed by development of new interventional procedures involving portal circulation. The majority of these interventions were developed for treatment of patients with symptoms secondary to portal hypertension (PH). Interventions involving portal vein circulation have an established position in the treatment of PH and other diseases, and further development of these methods can be expected.
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Abdyldaev, Ildar, Bektur Daniyarov, Semen Сhevgun, Toktosun Amatov, Daniyar Cholponbaev, and Kairat Nurbekov. "Dynamics of Endovascular Therapy Department’s work of Scientific Research Institute of Heart Surgery and Organ Transplantation, Bishkek, Kyrgyzstan." Heart, Vessels and Transplantation 3, Issue 2 (2019): 60. http://dx.doi.org/10.24969/hvt.2019.118.
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In recent years, high medical-social importance of most nosological types of cardiovascular diseases reflects an increase of surgery activity in this medical field. The enlargement of endovascular procedures is obvious and logical process. Today Endovascular therapy department of Scientific Research Institute of Heart Surgery and Organ Transplantation is one of the medical facility, where conducted scientific researches and new methods of diagnostics and treatment of vascular and cardiac diseases are being introduced.
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Chouvarine, Philippe, Željko Antić, Jana Lentes, et al. "Transcriptional and Mutational Profiling of B-Other Acute Lymphoblastic Leukemia for Improved Diagnostics." Cancers 13, no. 22 (2021): 5653. http://dx.doi.org/10.3390/cancers13225653.
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B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common cancer in children, and significant progress has been made in diagnostics and the treatment of this disease based on the subtypes of BCP-ALL. However, in a large proportion of cases (B-other), recurrent BCP-ALL-associated genomic alterations remain unidentifiable by current diagnostic procedures. In this study, we performed RNA sequencing and analyzed gene fusions, expression profiles, and mutations in diagnostic samples of 185 children with BCP-ALL. Gene expression clustering showed that a subset of B-other samples partially clusters with some of the known subgroups, particularly DUX4-positive. Mutation analysis coupled with gene expression profiling revealed the presence of distinctive BCP-ALL subgroups, characterized by the presence of mutations in known ALL driver genes, e.g., PAX5 and IKZF1. Moreover, we identified novel fusion partners of lymphoid lineage transcriptional factors ETV6, IKZF1 and PAX5. In addition, we report on low blast count detection thresholds and show that the use of EDTA tubes for sample collection does not have adverse effects on sequencing and downstream analysis. Taken together, our findings demonstrate the applicability of whole-transcriptome sequencing for personalized diagnostics in pediatric ALL, including tentative classification of the B-other cases that are difficult to diagnose using conventional methods.
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Левчишина, Е. В., and Е. В. Аксенов. "Diagnostics and Stenting of Coronary Arteries Aneurysms: Treatment of Myocardial Ischemia or Prevention of Complications?" Кардиология в Беларуси, no. 4 (November 5, 2021): 557–67. http://dx.doi.org/10.34883/pi.2021.13.4.005.
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Цель. Представить 16-летний опыт диагностики и лечения аневризм коронарных артерий (АКА) в одном кардиохирургическом центре. Материалы и методы. При написании статьи были использованы данные из медицинских карт и листов назначений стационарных пациентов с АКА, результаты коронарной ангиографии и записи операций. Результаты. За период с 2000 по 2016 г. из 3846 стентирований коронарных артерий шесть было выполнено по поводу АКА. Терапия АКА проводилась методом имплантации стентграфтов. Все шесть клинических случаев детально описаны, предоставлены данные литературы о классификации, частоте встречаемости, симптоматике и осложнениях, ассоциированных с данной патологией. Заключение. АКА в некоторых случаях ухудшают прогноз пациентов, особенно в сочетании с атеросклеротическими поражениями коронарного русла. Наличие АКА повышает риск тромбообразования в области коронарных артерий. Пациенты с АКА требуют более тщательного наблюдения с целью раннего выявления и лечения атеросклеротических стенозов коронарных артерий. Стентирование аневризм коронарных артерий с использованием стент-графтов является адекватным методом профилактики разрыва аневризм. Purpose. To present the 16-year experience of diagnostics and treatment of the coronary artery aneurysms (CAA) in a single cardiac surgery center. Materials and methods. The data on the patients with CAA was collected from the hospital records, coronary angiography, and procedure recordings. Results. 3846 coronary artery stentings were carried out in our center between 2000 and 2016, including 6 procedures performed due to CAA. Each CAA case was treated through stent-graft implantation. We describe all six cases in detail and provide the literature data on classification, epidemiology, clinical presentation, and complications associated with this condition. Conclusion. Coronary arteries aneurysms make a patient’s prognosis worse, especially in combination with coronary atherosclerotic lesions. The presence of CAA increases the risk of coronary arteries thrombosis. Patients with CAA require more careful observation for early detection and treatment of atherosclerotic lesions of coronary arteries. Stent-graft implantation is the best preventive method for CAA rupture.
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Romero, Flávio Ramalho, Eduardo De Freitas Bertolini, Adalberto Sestari, Sérgio Soares Guerrero, Ramon Barbalha Guerrero, and Modesto Cerione Jr. "The Role of Neuroendoscopy in the Treatment of Pineal Region Tumors." JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA 22, no. 2 (2018): 21–25. http://dx.doi.org/10.22290/jbnc.v22i2.953.
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Object. The authors report their experience in six patients presenting with pineal tumors and associated hydrocephalus who underwent an endoscopic biopsy procedure and third ventriculostomy (ETV) in a single setting. The purpose of this report is to discuss the role of neuroendoscopic procedures in the management of pineal region tumors. Methods. A retrospective review of patients undergoing simultaneous ETV and tumor biopsy was ndertaken. Neuroendoscopic surgery was first applied for tumor debulking with tissue diagnosis and gross morphological analysis of the tumor and the intraventricular structures, followed by third ventriculostomy. Subsequent procedures were determined on the basis of verified individual tumors. Results. Over a 2-year interval, 6 patients underwent simultaneous ETV and tumor management. These patients ranged from 6 to 54 years of age (mean 24.3 years). All cases were completed without complications or the need for an additional CSF diversionary procedure within 6 months. The diagnostic yield of the biopsy was 100%. Favorable therapeutic outcomes were obtained in all cases of germinoma and pineoblastoma, with follow-up periods ranging from 6 to 24 months. Conclusion. The majority of our patients with dilated ventricles were treated satisfactorily with effective neuroendoscopic procedures as the initial procedure, avoiding unnecessary craniotomy and promising excellent therapeutic outcomes.
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Clemens, Robert K., Tim Sebastian, Cindy Kerr, and Ahmad I. Alomari. "Clinical Uses and Short-Term Safety Profile of Ethiodized Poppy Seed Oil Contrast Agent in the Diagnosis and Treatment of Vascular Anomalies and Tumors." Diagnostics 11, no. 10 (2021): 1776. http://dx.doi.org/10.3390/diagnostics11101776.
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Background: There is a sparsity of data on the use of ethiodized poppy seed oil (EPO) contrast agent (Lipiodol) in patients. We investigated the safety of EPO in children, adolescents, and some adults for diagnostic and therapeutic interventions. Methods: All patients who underwent procedures with EPO between 1995 and 2014 were retrospectively included. Demographic characteristics, diagnosis, dose, route of administration, preparation of EPO in combination with other agents, and complications were recorded. Results: In 1422 procedures, EPO was used for diagnostic or treatment purposes performed in 683 patients. The mean patient age was 13.4 years (range: 2 months–50 years); 58% of patients were female. Venous malformations (n = 402, 58.9%) and arteriovenous malformations (n = 60, 8.8%) were the most common diagnosis. Combined vascular anomalies included capillary–lymphatic–venous malformations, fibroadipose vascular anomalies (n = 54, 7.9%), central conducting lymphatic anomalies (n = 31, 4.5%), lymphatic malformations (n = 24, 3.5%), aneurysmal bone cysts (n = 22, 3.2%), and vascularized tumors (n = 11, 1.6%). In 1384 procedures (96%), EPO was used in various combinations with sclerosing and embolization agents, including sodium tetradecyl sulfate, ethanol, and glue. The mean volume of EPO used in interventions was 3.85 mL (range: 0.1–25 mL) per procedure with a mean patient weight of 45.9 kg (range: 3.7–122.6 kg) and a weight-adjusted dose of 0.12 mL/kg (range: 0.001–1.73 mL/kg). In 56 procedures (4%), EPO was used as a single agent for diagnostic lymphangiography. The mean volume was 4.8 mL (range: 0.3–13 mL) per procedure with a mean patient weight of 27.4 kg (range: 2.4–79.3 kg) and a weight-adjusted dose of 0.2 mL/kg (range: 0.04–0.54 mL/kg). Procedural-related complications occurred in 25 (1.8%) procedures. The 20 minor and 5 major complications were related to the primary treatment agents. None of them were directly related to EPO. No allergic reactions were noted. Conclusion: The use of an ethiodized poppy seed oil contrast agent in children, adolescents, and adults for diagnostic or therapeutic purposes is safe.
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Seibaek, Lene, Lise Hounsgaard, and Niels Christian Hvidt. "Secular, Spiritual, and Religious Existential Concerns of Women with Ovarian Cancer during Final Diagnostics and Start of Treatment." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/765419.
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Introduction. This paper deals with secular, spiritual, and religious existential concerns during severe illness.Materials and Methods. Qualitative research interviews were made before and after surgery with women who underwent final diagnostics, surgery, and chemotherapy for ovarian cancer. By applying a phenomenological-hermeneutic text interpretation methodology the findings were systematically identified, placed into meaning structures, interpreted, and critically discussed.Results. The analysis offered insight into the complexity of challenges and personal development over time in being a woman with ovarian cancer during her first treatment period. Although the women experienced their health to be seriously threatened, they also felt hope, will, and courage. The diagnostic procedures and treatment had comprehensive impact on their lives. However, hope and spirituality were important resources of comfort and meaning.Conclusion. Hope and courage to face life represent significant personal resources that are created not only in the interplay between body and mind but also between patients and their healthcare professionals. The women dealt with this in a dialectical manner, so that hope and despair could be present simultaneously. In this process secular, spiritual, and religious existential meaning orientations assisted the women in creating new narratives and obtain new orientations in life.
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Salzberger, Bernd, Gabriele Birkenfeld, Michael Iberer, and Florian Hitzenbichler. "Infektionen als Ursache für Fieber unklarer Genese." DMW - Deutsche Medizinische Wochenschrift 142, no. 13 (2017): 951–60. http://dx.doi.org/10.1055/s-0043-102971.
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AbstractFever of unexplained (or unknown) origin (FUO) remains a relevant clinical problem even with modern diagnostic methods. In addition to the classical definition, new categories of FUO describe different clinical situations: nosocomial FUO, FUO in neutropenic/immundeficient patients and FUO in patients with HIV-infection. The new categories are defined by much shorter duration of fever, i. e. mostly three days. Each category of FUO shows a different spectrum of infectious diseases. Often, subacute bacterial endocarditis is very difficult to verify. In many cases, patients in intensive care suffer from FUO caused by reactivation of CMV. In patients with HIV the most important diagnostic indicator concerning the origin of infection is the degree of immundeficiency. Biological and nuclear medical (PET-CT) verification procedures have been established in diagnostics. A national or international register should be created with the purpose of data transfer and validation of strategies concerning the treatment of FUO.
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Upadhyay, Y. "Management Procedures Pain Used by Dental and Maxillofacial Surgeons: An Investigation With Special Regard To Odontalgia." Journal of Oral Health and Community Dentistry 9, no. 1 (2015): 1–4. http://dx.doi.org/10.5005/johcd-9-1-1.
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ABSTRACT Background Little is known about the procedures used by indian dental and maxillofacial surgeons treating patients suffering from chronic orofacial pain (COP). This study aimed to evaluate the ambulatory management of COP. Methods Using a standardized questionnaire we collected data of dental and maxillofacial surgeons treating patients with COP. Therapists described variables as patients’ demographics, chronic pain disorders and their aetiologies, own diagnostic and treatment principles during a period of 3 months. Results Although only 14.5% of the 520 addressed therapists returned completely evaluable questionnaires, 985 patients with COP could be identified. An orofacial pain syndrome named atypical odontalgia (16.0 %) was frequent. Although those patients revealed signs of chronification, pain therapists were rarely involved (12.5%). For assessing pain the use of Analogue Scales (7%) orinterventional diagnostics (4.6%) was uncommon. Despite the fact that surgical procedures are cofactors of COP therapists preferred further surgery (41.9%) and neglected the prescription of analgesics (15.7%). However, most therapists self-evaluated the efficacy of their pain management as good (69.7 %). Conclusion Often ambulatory dental and maxillofacial surgeons do not follow guidelines for COP management despite a high prevalence of severe orofacial pain syndromes.
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Mátrai, Zoltán, Gusztáv Gulyás, László Tóth, et al. "Special considerations of breast cancer treatment in an augmented breast." Orvosi Hetilap 152, no. 42 (2011): 1679–91. http://dx.doi.org/10.1556/oh.2011.29189.
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Breast augmentation surgery involving the use of implants has been one of the most popular plastic surgical procedures for decades. As the multi-million female population who received breast implants ages, the risk of cancer is increasing rapidly, therefore the incidence of malignant disease in association with breast implants will increase as well. Although there is no relationship between tumor development and implants, these cases require special considerations in diagnostics, therapy and follow-up methods. Appropriate multidisciplinary treatment of tumors in augmented breasts corresponding with modern oncoplastic principles can only be accomplished based on adequate oncological, breast and plastic surgical knowledge. Supposing a possible increase of this condition in Hungary, too, authors provide a wide review of the literature on the special oncological and esthetic considerations, for the first time in Hungarian language. Orv. Hetil., 2011, 152, 1679–1691.
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Mandic, Aljosa, and Tamara Vujkov. "Endometrial cancer: Diagnostic methods in postmenopausal vaginal bleeding." Archive of Oncology 11, no. 2 (2003): 97–101. http://dx.doi.org/10.2298/aoo0302097m.
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Postmenopausal vaginal bleeding (PMB) is the leading symptom of endometrial cancer. More than 70% of patients with endometrial cancer are postmenopausal. Despite PMB as a leading symptom in diagnosis of endometrial cancer, PMB could be caused by some benign processes in endometrium such as hyperplasia and focal endometrial disease, such as a polyp. The golden standard for histological evaluation of the endometrium is curettage. Transvaginal ultrasound (TVS) and measurement of endometrium thickness is also one of the favored methods in the last decade. Sonographic imaging of the endometrium can be extremely helpful, because endometrial cancer is nearly always associated with thickening and heterogeneity of the endometrium except in case of atrophy-associated adenocarcinoma of the endometrium, which is not associated with thickening. Hysteroscopy found place as a favored method in diagnosis of focal endometrial lesions. Saline infusion sonohysterography (SIS) is a relatively new imaging procedure. The SIS will show whether the endometrium is diffusely thickened, in which case curettage would be the next step, or focally thickened, in which case hysteroscopy with biopsy would be the next step. Combination of some diagnostic procedures, such as TVS, SIS, hysteroscopy, endometrial biopsy and curettage, should decrease false positive and false negative results which may affect the correct diagnosis and treatment.
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Goland, Javier, and Gustavo Doroszuk. "Transradial approach for endovascular diagnosis and treatment of ruptured cerebral aneurysms: A descriptive study." Surgical Neurology International 10 (May 10, 2019): 87. http://dx.doi.org/10.25259/sni-44-2019.
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Background: For cardiovascular procedures, the transradial approach has been documented to yield fewer complications than the femoral approach. It has become the approach of choice for diagnostic and therapeutic interventions involving the coronary arteries. However, few published data exist on using this approach for neuroendovascular procedures and we describe a series of ruptured cerebral aneurysms diagnosed and treated using the transradial approach. Methods: All patients scheduled for cerebral angiography to diagnose and treat subarachnoid hemorrhages at our hospital from June 2016 to May 2018, by right radial artery access, were recruited and followed prospectively. The main outcomes of interest were the length of the procedure (in minutes), the success of treatment, and the incidence of postprocedural complications. Results: Over the observation period, 59 patients (66% women, mean age = 48 years) with a combined 61 aneurysms treated were identified who met inclusion criteria. Of the 61 aneurysms treated, eight (13%) were within the posterior circulation (13%) and 53 (87%) the anterior circulation. Average procedural duration was 64.9 min. No occlusion or spasm of the radial artery was observed during any procedure. All patients had immediate pre- and post-embolization angiography, which revealed the guide catheter coming from the right subclavian artery. A radial pulse was evident after all interventions. All procedures were considered successful at treating the ruptured aneurysm, and no patient experienced a clinically significant complication related to the approach. Conclusions: The transradial approach is a viable option for the diagnosis and endovascular treatment of acute cerebral aneurysms in different locations.
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Khomenko, I. P., Ye V. Tsema, К. V. Gumenuk, S. V. Tertyshnyi, and V. Yu Shapovalov. "ORGANIZATION OF DIAGNOSTIC AND DYNAMIC OBSERVATION DURING RECONSTRUCTIVE RESTORATION OF GUNSHIRTING SOFT TISSUES." Kharkiv Surgical School, no. 2 (April 20, 2020): 119–26. http://dx.doi.org/10.37699/2308-7005.2.2020.24.
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Summary. Damage to the soft tissues of the human body is found both in peacetime and during the war, but the firearms nature has become relevant for Ukraine. Despite the experience gained surgery from previous wars in the treatment of gunshot injuries, there is still no generally accepted diagnostic scheme and classification for reconstructive closure of such specific injuries.
 The aim. Demonstrate the features of various methods for diagnosing gunshot wounds of soft tissues proposed for reconstruction of a damaged area.
 Results. In order to improve the quality of surgical care at the stages of medical evacuation, it is always necessary to carry out diagnostic procedures and treatment together. Sometimes it is impossible to implement medical care — it is on the front line, sometimes there is a lack of material resources — in the CDL, but it must be understood that the amount of diagnosis and treatment of a gunshot wound with soft tissue damage is always a difficult process.
 Conclusions. A multimodal approach to diagnostics and dynamic observation in the reconstruction of soft tissue gunshot injury not only restores the integrity of the damaged anatomical structure but also increases the percentage of functional capacity.
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Fundowicz, Magdalena, Miguel Macia, Susanna Marin, et al. "Preoperative radiotherapy for rectal cancer: a comparative study of quality control adherence at two cancer hospitals in Spain and Poland." Radiology and Oncology 48, no. 2 (2014): 210–18. http://dx.doi.org/10.2478/raon-2014-0008.
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Abstract Background. We performed a clinical audit of preoperative rectal cancer treatment at two European radiotherapy centres (Poland and Spain). The aim was to independently verify adherence to a selection of indicators of treatment quality and to identify any notable inter-institutional differences. Methods. A total of 162 patients, in Catalan Institute of Oncology (ICO) 68 and in Greater Poland Cancer Centre (GPCC) 94, diagnosed with locally advanced rectal cancer and treated with preoperative radiotherapy or radiochemotherapy were included in retrospective study. A total of 7 quality control measures were evaluated: waiting time, multidisciplinary treatment approach, portal verification, in vivo dosimetry, informed consent, guidelines for diagnostics and therapy, and patient monitoring during treatment. Results. Several differences were observed. Waiting time from pathomorphological diagnosis to initial consultation was 31 (ICO) vs. 8 (GPCC) days. Waiting time from the first visit to the beginning of the treatment was twice as long at the ICO. At the ICO, 82% of patient experienced treatment interruptions. The protocol for portal verification was the same at both institutions. In vivo dosimetry is not used for this treatment localization at the ICO. The ICO utilizes locally-developed guidelines for diagnostics and therapy, while the GPCC is currently developing its own guidelines. Conclusions. An independent external clinical audit is an excellent approach to identifying and resolving deficiencies in quality control procedures. We identified several procedures amenable to improvement. Both institutions have since implemented changes to improve quality standards. We believe that all radiotherapy centres should perform a comprehensive clinical audit to identify and rectify deficiencies.
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Jamróz, Barbara, Joanna Chmielewska-Walczak, and Magdalna Milewska. "Dysphagia among patients after total laryngectomy: diagnostic and therapeutic procedures." Polski Przegląd Otorynolaryngologiczny 9, no. 4 (2020): 1–5. http://dx.doi.org/10.5604/01.3001.0014.5705.
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Dysphagia concerns 10–89% patients after total laryngectomy; to a greater extent, it concerns patients receiving complementary radiotherapy. The disease mechanism is associated with anatomical changes after surgery (scope of surgery) or complications of adjuvant therapy (xerostomia, neuropathy, swelling of tissue, etc.). The above changes lead to: decreased mobility of the lateral walls of the pharynx and tongue retraction, the occurrence of lingual pumping, decreased swallowing reflex, weakening of the upper esophageal sphincter opening, contraction of the cricopharyngeal muscle, tissue fibrosis, formation of pharyngeal pseudodiverticulum, etc. As a result: regurgitation of food through the nose and oral cavity, food sticking in middle and lower pharynx, prolongation of bolus transit time. Upon the formation of tracheoesophageal fistula, there may be aspiration of gastric contents. The above changes considerably reduce patients’ quality of life after surgery. The diagnostic protocol includes: medical interview (questionnaires can be helpful such as: EAT 10, SSQ, MDADI, DHI), clinical swallowing assessment and instrumental examinations: primarily videofluoroscopy but also endoscopic evaluation of swallowing. In selected cases, multifrequency manometry is necessary. The treatment options include: surgical methods (e.g. balloon dilatation of the upper esophageal sphincter, cricopharyngeal myotomy, pharyngeal plexus neurectomy, removal of the pharyngeal pseudodiverticulum), conservative methods (e.g. botulinum toxin injection of the upper esophageal sphincter, speech therapy, nutritional treatment) and supportive methods such as consultation with a psychologis physiotherapist, clinical dietitian. The selection of a specific treatment method should be preceded by a diagnostic process in which the mechanism of functional disorders related to voice formation and swallowing will be established.
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Зилов, V. Zilov, Черныш, et al. "Monitoring of the Functional State of Patients on the Magnitude of Testing Voltage in the Reference Point." Journal of New Medical Technologies 22, no. 4 (2015): 139–43. http://dx.doi.org/10.12737/17039.
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Reference principle of electropuncture diagnostics is based on prior determining the individual
 testing voltage using the “reference” point with subsequent measurement of the currents in the acupuncture
 points. This approach improves the accuracy of estimation of functional states in comparison with other
 methods of electropuncture diagnostics and provides the necessary personalization of diagnostic procedures.
 Based on analyzing and summarizing the experience of the clinical use of electropuncture diagnostics
 ʺBioreperʺ, its new features are revealed. It is found that the magnitude of testing voltage in a reference point
 is a non‐specific indicator of the level of health and the degree of distress the body. It is shown that the measurement
 of testing voltage in the reference point allows to monitoring the functional status of patients, to
 identifying the severity of pathological changes in the body and to assessing their dynamics during treatment
 and rehabilitation. The close correlation between the magnitude of testing voltage and the severity of
 pathogenesis reactions of cardiovascular disease, broncho‐pulmonary, digestive and musculoskeletal systems
 was revealed. This phenomenon has been confirmed in animal studies (dogs) with the pathology of the stomach, pancreas and gall bladder. It is also found a direct correlation between the magnitude of testing
 voltage in the reference point and the severity of pain.
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Skodric-Trifunovic, Vesna, Violeta Vucinic, Radoje Colovic, Jelica Videnovic-Ivanov, Vladimir Zugic, and Jelena Stojsic. "Liver and splenic sarcoidosis: Diagnostic procedures." Medical review 57, no. 9-10 (2004): 462–66. http://dx.doi.org/10.2298/mpns0410462s.
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Introduction Clinical studies indicate involvement of the liver and spleen in approximately 20-30% of patients affected with sarcoidosis and their detection should be based on a standardized diagnostic procedure. Diagnostic procedures Ultrasonography is a reliable and safe method to assess changes related to size and structure of the affected organs that are pathognomonic for sarcoidosis. Further evaluation may include computerized tomography or magnetic resonance, while percutaneous needle aspiration biopsy or laparoscopy may also be applied when indicated. The most important criterion used for final diagnosis is pathohistological evidence of epithelioid noncaseating granuloma in bioptic material along with already established sarcoidosis of the lungs or some other organ. Material and methods The study on the incidence of liver and spleen sarcoidosis included a group of 130 patients affected with sarcoidosis hospitalized at the Institute of Pulmonary Diseases and Tuberculosis, Clinical Center of Serbia, over the period 2002-2003. Results The analysis evidenced that 31.5% of sarcoidosis patients had pathognomonic echographic findings of abdominal organs: splenomegaly (13%), hepatomegaly (10.8%) and hepatosplenomegaly (7.7%). Three patients underwent surgical treatment of liver and spleen sarcoidosis. Conclusion Pathognomonic findings of liver and spleen sarcoidosis were evidenced in approximately one third of sarcoidosis cases and they represented a significant parameter for further therapy, particularly in chronic patients.
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Debela, Dejene Tolossa, Seke GY Muzazu, Kidist Digamo Heraro, et al. "New approaches and procedures for cancer treatment: Current perspectives." SAGE Open Medicine 9 (January 2021): 205031212110343. http://dx.doi.org/10.1177/20503121211034366.
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Cancer is a global health problem responsible for one in six deaths worldwide. Treating cancer has been a highly complex process. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have been in use, while significant advances are being made in recent times, including stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemodynamic therapy, sonodynamic therapy, and ferroptosis-based therapy. Current methods in oncology focus on the development of safe and efficient cancer nanomedicines. Stem cell therapy has brought promising efficacy in regenerating and repairing diseased or damaged tissues by targeting both primary and metastatic cancer foci, and nanoparticles brought new diagnostic and therapeutic options. Targeted therapy possessed breakthrough potential inhibiting the growth and spread of specific cancer cells, causing less damage to healthy cells. Ablation therapy has emerged as a minimally invasive procedure that burns or freezes cancers without the need for open surgery. Natural antioxidants demonstrated potential tracking down free radicals and neutralizing their harmful effects thereby treating or preventing cancer. Several new technologies are currently under research in clinical trials, and some of them have already been approved. This review presented an update on recent advances and breakthroughs in cancer therapies.
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Vankevičiūtė, Rasa Aurelija, Arijanda Neverauskienė, and Evaldas Lukoševičius. "Fibro-osseous lesions of craniofacial bones in children: case reports." Acta medica Lituanica 20, no. 2 (2013): 93–101. http://dx.doi.org/10.6001/actamedica.v20i2.2698.
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Background. The aim of this article is to present rare clinical cases of craniofacial fibro-osseous lesions in pediatric patients. Materials and methods. In this report we present 3 cases of fibroosseous craniofacial lesions in pediatric patients. Lesions of bones resembled fibrous dysplasia, dysplastic fibroma and chronic osteomyelitis which were confirmed or suspected by clinical signs, radiographic visualization methods and histopathological investigations for these patients. The diagnostic workup, treatment, follow-up procedures and a literature review are presented. Results and conclusions. Fibro-osseous lesions of the jaws and skull manifest in a similar pattern. Conditions are easily revealed upon examination and with the help of conventional diagnostics, however, differential diagnosis using only radiological imaging is impossible. Histological findings remain a tool of choice determining the treatment strategy and outcome of the patients but it is not always available due to anatomical and functional considerations. Treatment of fibro-osseous lesions of the face and skull is highly individualized and depends on various qualities of the lesion and the patient himself. All patients received palliative symptomatic treatment to alleviate their conditions and in all cases obtaining a histology specimen and surgical intervention for treatment of the lesion was considered as a treatment option only if it was seen being safe and as least traumatic as possible because of the functional and psychological importance of the craniofacial region.
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Altmeyer, P., M. Stücker, and S. Reich-Schupke. "Actual procedures of diagnostics and treatments of crural venous ulcer in specialized German praxis and clinics." Phlebologie 38, no. 02 (2009): 77–82. http://dx.doi.org/10.1055/s-0037-1622259.
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Summary Background: To evaluate the implementation of the guidelines of the German Society of Phlebology for venous crural ulcer a survey was conducted during the annual meeting of the German Society of Phlebology 2008 in Bochum. Methods: All 719 medical participants got an anonymized questionnaire asking for supply of crural ulcer in their institution. Results: The recurrent 66 questionnaires (9.2%) were filled by colleagues from practice or hospital, mostly surgeons, dermatologists, phlebologists and vascular surgeons. As basic diagnostics vein doppler (56.1%), duplex (75.8%) or measurement of brachial-ankleindex (83.3%) were performed. Compression therapy is used in all institutions. Mainly used wound dressings are polyurethane foam dressings, alginates, hydrocolloids and silver dressings. About 2/3 conduct surgical therapy of ulcers. Conclusion: Supply of ulcus cruris by the participants of the annual meeting of the DGP corresponds mainly, but not in all aspects to the guidelines. Further efforts for a spread of the guidelines are necessary.
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Ash, David, and Michael Zetz. "Diagnostic and operative arthroscopy of the temporomandibular joint." International Journal of Orofacial Myology 15, no. 2 (1989): 9–11. http://dx.doi.org/10.52010/ijom.1989.15.2.3.
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Introduction: In the past, most efforts aimed at treating internal derangement of the temporomandibular joint (TMJ) have involved nonsurgical modalities and/or conventional open surgical procedures (i.e. arthrotomy). Common nonsurgical methods include physical therapy, bite splint appliances, anti-inflammatory medications and patient education regarding potentially destructive habits such as clenching and bruxing. If these methods failed to yield symptomatic and functional improvement, open arthrotomy of the joint was often proposed. These procedures consist of disk repositioning, arthroplasty, meniscectomy with and without implants and other treatments (AAOMS, 1984). The purpose of this article is to describe TMJ arthroscopy: a useful alternative to open surgery for the diagnosis and treatment of intracapsular TMJ pathology.
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Osterhoff, Georg, Klaus Schnake, Max J. Scheyerer, et al. "Recommendations for Diagnosis and Treatment of Odontoid Fractures in Geriatric Patients." Zeitschrift für Orthopädie und Unfallchirurgie 158, no. 06 (2019): 647–56. http://dx.doi.org/10.1055/a-0989-2791.
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Abstract Background Odontoid fractures in geriatric patients represent an entity of increasing incidence with a high rate of morbidity and mortality. The optimal diagnostic and therapeutic management is being controversially discussed in the literature. Methods In a consensus process and based on the current literature, the members of the working groups “Osteoporotic Fractures” and “Upper Cervical Spine” of the German Society for Orthopaedics and Trauma Surgery (DGOU) defined recommendations for the diagnostics and treatment of odontoid fractures in geriatric patients. Results For the diagnosis of odontoid fractures in symptomatic patients, computed tomography represents the gold standard, along with conventional radiographs. Magnetic resonance and dynamic imaging can be used as ancillary imaging modalities. With regard to fracture classification, the systems described by Anderson/DʼAlonzo and by Eysel/Roosen have proved to be of value. A treatment algorithm was developed based on these classifications. Anderson/DʼAlonzo type 1, type 3, and non-displaced type 2 fractures usually can be treated non-operatively. However, a close clinical and radiological follow-up is essential. In Anderson/DʼAlonzo type 2 fractures, operative treatment is associated with better fracture healing. Displaced type 2 and type 3 fractures should be stabilized operatively. Type 2 fractures with suitable fracture patterns (Eysel/Roosen 2A/B) can be stabilized anteriorly. Posterior C I/II-stabilization procedures are well established and suitable for all fracture patterns.
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Vrzic-Petronijevic, S., I. Likic-Ladjevic, M. Petronijevic, R. Argirovic, and N. N. Ladjevic. "Diagnosis and surgical therapy of uterine sarkoma." Acta chirurgica Iugoslavica 53, no. 3 (2006): 67–72. http://dx.doi.org/10.2298/aci0603067v.
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Introduction: Uterine sarcomas are rare gynecological neoplasms and their classification is complicated. Uterine sarcoma is usually diagnosed in postmenopausal women and the diagnosis is often accidental and postoperative. Aim of this study was to present clinical and pathological characteristics of uterine sarcomas, diagnostic procedures, treatment and two-, three- and five-years cumulative survival rates. Materials and methods: The retrospective study of 61 cases of uterine sarcomas was conducted. Cases were distributed into groups based on definitive diagnosis of uterine sarcoma: group of leiomyosarcomas (LMS), carcinosarcoma (CS), endometrial stromal sarcomas (ESS), adenosarcomas (AS) and other rare uterine sarcomas. We investigated patients with clinical and pathological characteristics of uterine sarcomas, diagnostic procedures and treatment. Survival rate was calculated by Kaplan-Meier method. Results: From 61 patients 43 patients (70.49%) were postmenopausal. Mean period from menopause until appearance of symptoms was 14,63 years. One or more risk factors were present in 46 (75.4%) patients. Diagnosis of uterine sarcoma were established averagely 7.38 months after appearance of symptoms. 50 patients (82.0%) underwent one or more diagnostic procedures. Preoperative diagnosis of uterine sarcoma was established in 42.5% of patients. 53 (86.9%) of patients were treated operatively. The most used operative procedure (60,7%) was total hysterectomy with bilateral salpingooophorectomy. Postoperative pathohistologic analysis showed that low grade (LG) leiomyosarcoma were present in 19 (35.9%) cases, high grade (HG) leiomyosarcoma in 1 (1.9%) case, carcinosarcoma in 14 (26.4%) cases, low grade (LG) endometrial stromal sarcoma in 5 (9.4%) cases, high grade (HG) endometrial stromal sarcoma in 9 (17.0%) cases, adenosarcoma in 2 (3.8%) cases, and 2 cases of rare uterine sarcomas: 1 (1.9%) MALT HG lymphoma and 1(1.9%) malignant hemangiopericytoma. In one case of ESS (1.9%) only adenomyosis was found postoperatively suggesting that the whole tumour was removed during diagnostic procedure. Eight patients were not treated operatively. Two-years cumulative survival rate was 74.3%, three-years cumulative survival rate was 71.1%, and five years survival rate was 64.3%. Discussion: Average age, percent of postmenopausal patients and the mean age at the time of menopause in our studied correlate with current data. Clinical presentation of uterine sarcoma is associated with obesity and hypertension in more than 30% of cases, which is approved in our study. For early diagnostics it is important to notice that risk factors are similar to those connected with far more frequent endometrial carcinoma. Postmenopausal abnormal bleeding was the main reason for medical examination, explaining relatively short period for establishing the diagnosis in this group of patients. The variety of clinical findings in our studied group showed that the diagnosis must be based on preoperative pathohistology. Conclusion: Adequate diagnosis and treatment of uterine sarcoma is possible with regular yearly or more frequent follow-up, especially in postmenopausal women with known risk factors present. We need special attention for unclear symptoms and postmenopausal bleeding and we need to use all diagnostic procedures soon as possible including preoperative histology because early metastases are characteristic for uterine sarcomas. Factor of the most important predictive value is histologic grade. .
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Djurdjevic, Srdjan, Sanja Stojanovic, Marijana Basta-Nikolic, and Dragan Nikolic. "Novel diagnostic and therapeutic approaches to the treatment of ovarian cancer." Medical review 72, no. 1-2 (2019): 11–16. http://dx.doi.org/10.2298/mpns1902011d.
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Introduction. Ovarian cancer is an intra-abdominal, chemosensitive, chronic disease and according to current protocols, it is primarily treated with surgery followed by adjuvant chemotherapy. In Serbia, 820 cases of ovarian cancer are newly diagnosed annually. The aim of the study is to present the results of surgical treatment in 304 patients with ovarian cancer, treated during a 15-year period (2003 - 2017) at the Clinic of Gynecology and Obstetrics, Clinical Center of Vojvodina in Novi Sad. Material and Methods. Before the operation, clinical, gynecological, ultrasonography examination and analysis of cancer antigen 125 blood concentrations were performed in all patients. Based on basic diagnostics, additional pelvic, abdominal and thoracic computed tomography or magnetic resonance imaging studies, together with colonoscopy if needed, were performed. The selection of the type and extent of surgical procedure was based on intraoperative assessment of the stage of disease, intraoperative histopathological confirmation of ovarian cancer, wish for fertility preservation and general patient?s condition. Exclusion criteria were histopathologically confirmed benign or borderline ovarian tumors, i. e. absence of cancer in the final microscopic specimen. Results. The patients? age ranged from 19 - 88 years, with a median of 53.4 years. According to the International Federation of Gynecology and Obstetrics staging, most patients had stage III - 98 (33.1%) and epithelial ovarian cancer - 240 (84.2%). The most common surgical procedures were hysterectomy with bilateral adnexectomy and omentectomy, whereas cytological analysis was performed in 138 (45.4%) treated patients. Complications were recorded in 13 (4.3%) operated patients with inflammation and wound seroma being the most common (4 patients - 1.3% of cases). Conclusion. Ovarian cancer treatment is planned individually, depending on the stage of the disease, histological tumor type, patient?s general condition, wish for fertility-sparing treatment and technical capacity of the institution where the treatment is performed.
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Contegiacomo, Andrea, Enrico Maria Amodeo, Alessandro Cina, et al. "Renal artery embolization for iatrogenic renal vascular injuries management: 5 years’ experience." British Journal of Radiology 93, no. 1106 (2020): 20190256. http://dx.doi.org/10.1259/bjr.20190256.
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Objective: Evaluate the efficacy and safety of renal artery embolization (RAE) for iatrogenic renal vascular injuries (IRVI) management at Fondazione Policlinico Universitario "A. Gemelli" IRCCS, in the last 5 years. Methods: Retrospective analysis of all RAE procedures performed from January 2013 to December 2017. Patients-related (age, sex, vascular variants, hemoglobin and serum creatinine), IRVI-related (type and vascular level of IRVI, presence and extension of hematoma), management-related (temporal interval between diagnostic imaging and RAE) and procedure-related (embolic materials, technical success, clinical success and complications) parameters were evaluated. Results: 28 RAE procedures performed on 28 patients (21 males; 7 females) were included. 19/28 patients had pseudoaneurysm, 7/28 active bleeding and 1/28 arteriovenous fistula; 4/28 patients had a combination of 2 IRVI. The extent of perirenal hematoma showed correlation with the cause of IRVI (p = 0.028). Technical success was achieved in all patients whereas clinical success in 25/28 (89.3%), with 3 patients requiring re-treatment. Minor complications were observed during 2/28 (7.1%) endovascular procedures. No major complications occurred. A longer procedural time was observed in patients with lower pre-procedural levels of hemoglobin (p = 0.016). No differences were found in mean serum creatinine (p = 0.23) before and immediately after treatment, while values of creatinine at 1 week from the procedure were significantly lower (p = 0.04). Conclusion: RAE is safe and effective for the management of iatrogenic IRVI showing high technical and clinical success rate and low complication rate. Advances in knowledge: Low pre-procedural hemoglobin levels increase procedural duration time. Glue alone or in combination with other materials is as safe as coils.
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Khaustov, A. V., N. G. Manelis, S. N. Pancyr, N. A. Mamontova, and N. N. Volgina. "Comparative analysis of diagnostic tools that are used in educational facilities of Moscow city during the work with children with autism spectrum disorder." Autism and Developmental Disorders 13, no. 2 (2015): 8–16. http://dx.doi.org/10.17759/autdd.2015130202.
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Currently one of the thorniest question of Russian education and psychology is the problem of diagnostics and functional assessment of skills in children with autism spectrum disorders since existing methods usually access one specific area of development or small set of skills. Urgency of this issue is explained by necessity of development for each of these children individual educational and treatment plan aimed at their socialization, raising their social adaptation, development and efficient education. Development of such plans is complicated due to lack of the unified approach to the issues of education and treatment of children with autism and may be based only on accurate data about developmental level of each child, that can be determined only through the use of special assessment tools. In the results of the research the diagnostics procedures that are used in the educational facilities of Moscow in order to develop individual educational plan for children with autistic spectrum disorders were determined and described, the comparative analysis of these diagnostics tools was accomplished, the areas of used of each method was determined. Methodical recommendations were completed within the framework of the research work of the professionals of the Center for Psychological, Medical and Social Support to Children and Adolescents of the Moscow State University of Psychology and Education.